DK1881850T3 - GLP-1-PEGylerede forbindelser - Google Patents
GLP-1-PEGylerede forbindelserInfo
- Publication number
- DK1881850T3 DK1881850T3 DK06759598.3T DK06759598T DK1881850T3 DK 1881850 T3 DK1881850 T3 DK 1881850T3 DK 06759598 T DK06759598 T DK 06759598T DK 1881850 T3 DK1881850 T3 DK 1881850T3
- Authority
- DK
- Denmark
- Prior art keywords
- glp
- compounds
- decreasing
- intestinal
- gastric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68068805P | 2005-05-13 | 2005-05-13 | |
PCT/US2006/018284 WO2006124529A1 (en) | 2005-05-13 | 2006-05-11 | Glp-1 pegylated compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1881850T3 true DK1881850T3 (da) | 2011-01-03 |
Family
ID=36926842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06759598.3T DK1881850T3 (da) | 2005-05-13 | 2006-05-11 | GLP-1-PEGylerede forbindelser |
Country Status (25)
Country | Link |
---|---|
US (1) | US8183340B2 (da) |
EP (1) | EP1881850B1 (da) |
JP (2) | JP5225074B2 (da) |
KR (1) | KR101011081B1 (da) |
CN (1) | CN101166545B (da) |
AT (1) | ATE482724T1 (da) |
AU (1) | AU2006247734B2 (da) |
BR (1) | BRPI0609676A2 (da) |
CA (1) | CA2608311C (da) |
CY (1) | CY1110853T1 (da) |
DE (1) | DE602006017202D1 (da) |
DK (1) | DK1881850T3 (da) |
EA (1) | EA012442B1 (da) |
ES (1) | ES2350852T3 (da) |
HR (1) | HRP20100543T1 (da) |
IL (1) | IL186772A0 (da) |
ME (1) | ME02786B (da) |
MX (1) | MX2007014052A (da) |
NO (1) | NO20076415L (da) |
PL (1) | PL1881850T3 (da) |
PT (1) | PT1881850E (da) |
RS (1) | RS51637B (da) |
SI (1) | SI1881850T1 (da) |
UA (1) | UA90896C2 (da) |
WO (1) | WO2006124529A1 (da) |
Families Citing this family (77)
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WO2007075534A2 (en) | 2005-12-16 | 2007-07-05 | Nektar Therapeutics Al, Corporation | Polymer conjugates of glp-1 |
US8501693B2 (en) | 2006-08-04 | 2013-08-06 | Amylin Pharmaceuticals, Llc | Use of exendins and exendin agonists and GLP-1 receptor agonists for altering the concentration of fibrinogen |
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JP2008169195A (ja) | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
AU2008205229B2 (en) | 2007-01-05 | 2014-03-27 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological pH buffers |
CA2677932A1 (en) | 2007-02-15 | 2008-08-21 | Indiana University Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
GB2448895A (en) * | 2007-05-01 | 2008-11-05 | Activotec Spp Ltd | GLP-1 like compounds and uses thereof |
EP2164519A2 (en) * | 2007-06-08 | 2010-03-24 | Ascendis Pharma AS | Long-acting polymeric prodrugs of exendin |
JP2010535781A (ja) * | 2007-08-03 | 2010-11-25 | イーライ リリー アンド カンパニー | 肥満に対する処置 |
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JP5771005B2 (ja) | 2007-10-30 | 2015-08-26 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | グルカゴンアンタゴニスト及びglp−1アゴニスト活性を示す化合物 |
CA2707861A1 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Glucagon antagonists |
DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
WO2009075788A1 (en) * | 2007-12-05 | 2009-06-18 | Semprus Biociences Corporation | Synthetic non-fouling amino acids |
TWI451876B (zh) * | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
MX2010012695A (es) | 2008-06-17 | 2011-03-15 | Univ Indiana Res & Tech Corp | Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico. |
EP2300037B1 (en) | 2008-06-17 | 2016-03-30 | Indiana University Research and Technology Corporation | Glucagon/glp-1 receptor co-agonists |
PL2300035T3 (pl) | 2008-06-17 | 2016-04-29 | Univ Indiana Res & Tech Corp | Mieszani agoniści na bazie GIP do leczenia zaburzeń metabolicznych i otyłości |
EP2310372B1 (en) | 2008-07-09 | 2012-05-23 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
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KR20120087875A (ko) | 2009-06-16 | 2012-08-07 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | Gip 수용체-활성 글루카곤 화합물 |
CN101993485B (zh) * | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
DK2470552T3 (da) | 2009-08-26 | 2014-02-17 | Sanofi Sa | Hidtil ukendte, krystallinske, heteroaromatiske fluorglycosidhydrater, lægemidler, der omfatter disse forbindelser, og deres anvendelse |
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US8703701B2 (en) | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
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WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
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CN103179976A (zh) | 2010-05-13 | 2013-06-26 | 印第安纳大学研究及科技有限公司 | 呈现g蛋白偶联受体活性的胰高血糖素超家族肽 |
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US8507428B2 (en) | 2010-12-22 | 2013-08-13 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting GIP receptor activity |
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JP6691125B2 (ja) | 2014-12-17 | 2020-04-28 | ノヴォ ノルディスク アー/エス | Glp−1誘導体及びその使用 |
US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
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CA2468700A1 (en) * | 2002-01-08 | 2003-07-17 | Eli Lilly And Company | Extended glucagon-like peptide-1 analogs |
PL1605897T3 (pl) * | 2003-03-19 | 2012-12-31 | Lilly Co Eli | Związki będące połączeniem GLP-1 z poli(glikolem etylenowym) |
BRPI0411112A (pt) * | 2003-06-12 | 2006-07-18 | Lilly Co Eli | proteìna de fusão heteróloga, polinucleotìdeo, vetor, célula hospedeira, processo para produzir uma proteìna de fusão heteróloga, método para tratar um paciente, e, uso de proteìna de fusão heteróloga |
PL1641823T3 (pl) * | 2003-06-12 | 2012-02-29 | Lilly Co Eli | Białka fuzyjne analogu GLP-1 |
CN1586625A (zh) * | 2004-07-21 | 2005-03-02 | 上海第二医科大学附属瑞金医院 | 用于肿瘤显像和治疗的联合物及其制备方法 |
-
2006
- 2006-05-11 PL PL06759598T patent/PL1881850T3/pl unknown
- 2006-05-11 AU AU2006247734A patent/AU2006247734B2/en not_active Ceased
- 2006-05-11 EP EP06759598A patent/EP1881850B1/en active Active
- 2006-05-11 PT PT06759598T patent/PT1881850E/pt unknown
- 2006-05-11 MX MX2007014052A patent/MX2007014052A/es active IP Right Grant
- 2006-05-11 CA CA2608311A patent/CA2608311C/en not_active Expired - Fee Related
- 2006-05-11 SI SI200630849T patent/SI1881850T1/sl unknown
- 2006-05-11 US US11/913,365 patent/US8183340B2/en not_active Expired - Fee Related
- 2006-05-11 WO PCT/US2006/018284 patent/WO2006124529A1/en active Application Filing
- 2006-05-11 CN CN2006800147033A patent/CN101166545B/zh not_active Expired - Fee Related
- 2006-05-11 RS RS20100486A patent/RS51637B/en unknown
- 2006-05-11 KR KR1020077026259A patent/KR101011081B1/ko not_active IP Right Cessation
- 2006-05-11 ME MEP-2010-486A patent/ME02786B/me unknown
- 2006-05-11 EA EA200702487A patent/EA012442B1/ru not_active IP Right Cessation
- 2006-05-11 BR BRPI0609676-0A patent/BRPI0609676A2/pt not_active IP Right Cessation
- 2006-05-11 DE DE602006017202T patent/DE602006017202D1/de active Active
- 2006-05-11 AT AT06759598T patent/ATE482724T1/de active
- 2006-05-11 DK DK06759598.3T patent/DK1881850T3/da active
- 2006-05-11 JP JP2008511371A patent/JP5225074B2/ja not_active Expired - Fee Related
- 2006-05-11 ES ES06759598T patent/ES2350852T3/es active Active
- 2006-11-05 UA UAA200712483A patent/UA90896C2/ru unknown
-
2007
- 2007-10-18 IL IL186772A patent/IL186772A0/en unknown
- 2007-12-12 NO NO20076415A patent/NO20076415L/no not_active Application Discontinuation
-
2010
- 2010-10-05 HR HR20100543T patent/HRP20100543T1/hr unknown
- 2010-10-21 CY CY20101100945T patent/CY1110853T1/el unknown
-
2012
- 2012-12-06 JP JP2012266820A patent/JP2013079256A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ME02786B (me) | 2011-10-31 |
JP2008540565A (ja) | 2008-11-20 |
SI1881850T1 (sl) | 2011-01-31 |
PT1881850E (pt) | 2010-11-26 |
HRP20100543T1 (hr) | 2010-11-30 |
UA90896C2 (en) | 2010-06-10 |
EA012442B1 (ru) | 2009-10-30 |
ES2350852T3 (es) | 2011-01-27 |
CA2608311A1 (en) | 2006-11-23 |
BRPI0609676A2 (pt) | 2011-10-18 |
EP1881850A1 (en) | 2008-01-30 |
JP2013079256A (ja) | 2013-05-02 |
NO20076415L (no) | 2007-12-12 |
EP1881850B1 (en) | 2010-09-29 |
MX2007014052A (es) | 2008-02-05 |
CN101166545A (zh) | 2008-04-23 |
DE602006017202D1 (de) | 2010-11-11 |
US20090215981A1 (en) | 2009-08-27 |
WO2006124529A1 (en) | 2006-11-23 |
EA200702487A1 (ru) | 2008-04-28 |
JP5225074B2 (ja) | 2013-07-03 |
IL186772A0 (en) | 2008-02-09 |
AU2006247734A1 (en) | 2006-11-23 |
RS51637B (en) | 2011-10-31 |
CY1110853T1 (el) | 2012-05-23 |
ATE482724T1 (de) | 2010-10-15 |
CA2608311C (en) | 2012-11-27 |
KR101011081B1 (ko) | 2011-01-25 |
CN101166545B (zh) | 2011-06-15 |
KR20080025361A (ko) | 2008-03-20 |
US8183340B2 (en) | 2012-05-22 |
AU2006247734B2 (en) | 2011-06-23 |
PL1881850T3 (pl) | 2011-03-31 |
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