JP2011506734A5 - - Google Patents

Info

Publication number

JP2011506734A5

JP2011506734A5 JP2010538766A JP2010538766A JP2011506734A5 JP 2011506734 A5 JP2011506734 A5 JP 2011506734A5 JP 2010538766 A JP2010538766 A JP 2010538766A JP 2010538766 A JP2010538766 A JP 2010538766A JP 2011506734 A5 JP2011506734 A5 JP 2011506734A5

Authority

JP

Japan

Prior art keywords

hyaluronic acid

range

microbeads

crosslinked

dvs

Prior art date

2008-12-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 17
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 9
• 229920002674 hyaluronan Polymers 0.000 claims 9
• 229960003160 hyaluronic acid Drugs 0.000 claims 9
• AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 8
• 239000011325 microbead Substances 0.000 claims 7
• 239000000872 buffer Substances 0.000 claims 5
• 238000000746 purification Methods 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
• 239000012670 alkaline solution Substances 0.000 claims 2
• 239000006172 buffering agent Substances 0.000 claims 2
• 239000011259 mixed solution Substances 0.000 claims 2
• 238000003756 stirring Methods 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• 241000193830 Bacillus <bacterium> Species 0.000 claims 1
• 229910019142 PO4 Inorganic materials 0.000 claims 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 239000011324 bead Substances 0.000 claims 1
• 238000004132 cross linking Methods 0.000 claims 1
• 239000008367 deionised water Substances 0.000 claims 1
• 229910021641 deionized water Inorganic materials 0.000 claims 1
• 238000000502 dialysis Methods 0.000 claims 1
• 239000000839 emulsion Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• 230000003472 neutralizing effect Effects 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1
• 239000008363 phosphate buffer Substances 0.000 claims 1
• 239000002504 physiological saline solution Substances 0.000 claims 1
• 239000003755 preservative agent Substances 0.000 claims 1
• 230000002335 preservative effect Effects 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 239000007762 w/o emulsion Substances 0.000 claims 1