CA2709824A1 - Crosslinked hyaluronic acid in emulsion - Google Patents
Crosslinked hyaluronic acid in emulsion Download PDFInfo
- Publication number
- CA2709824A1 CA2709824A1 CA2709824A CA2709824A CA2709824A1 CA 2709824 A1 CA2709824 A1 CA 2709824A1 CA 2709824 A CA2709824 A CA 2709824A CA 2709824 A CA2709824 A CA 2709824A CA 2709824 A1 CA2709824 A1 CA 2709824A1
- Authority
- CA
- Canada
- Prior art keywords
- hyaluronic acid
- microbead
- range
- microbeads
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 121
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 112
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 110
- 239000000839 emulsion Substances 0.000 title claims abstract description 41
- 239000011325 microbead Substances 0.000 claims abstract description 79
- 238000000034 method Methods 0.000 claims abstract description 59
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 150000003839 salts Chemical class 0.000 claims abstract description 31
- 238000003756 stirring Methods 0.000 claims abstract description 29
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 26
- 239000000243 solution Substances 0.000 claims abstract description 25
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 239000012670 alkaline solution Substances 0.000 claims abstract description 9
- 239000007762 w/o emulsion Substances 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims description 50
- 239000003921 oil Substances 0.000 claims description 28
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 239000000872 buffer Substances 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 18
- 238000004519 manufacturing process Methods 0.000 claims description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 17
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 11
- 238000004132 cross linking Methods 0.000 claims description 11
- 229940014041 hyaluronate Drugs 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
- 239000013543 active substance Substances 0.000 claims description 8
- 238000000502 dialysis Methods 0.000 claims description 8
- 239000011259 mixed solution Substances 0.000 claims description 7
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 6
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 6
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 6
- 239000003981 vehicle Substances 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 201000004384 Alopecia Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 206010052428 Wound Diseases 0.000 claims description 4
- 208000027418 Wounds and injury Diseases 0.000 claims description 4
- 230000003676 hair loss Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000008363 phosphate buffer Substances 0.000 claims description 4
- 230000029663 wound healing Effects 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 3
- 239000004909 Moisturizer Substances 0.000 claims description 3
- 230000033115 angiogenesis Effects 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 238000012377 drug delivery Methods 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims description 3
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 230000001333 moisturizer Effects 0.000 claims description 3
- 230000003472 neutralizing effect Effects 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 230000003416 augmentation Effects 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 229910017052 cobalt Inorganic materials 0.000 claims description 2
- 239000010941 cobalt Substances 0.000 claims description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 238000009792 diffusion process Methods 0.000 claims description 2
- 230000002500 effect on skin Effects 0.000 claims description 2
- 208000024963 hair loss Diseases 0.000 claims description 2
- VJVOFLWZDWLHNR-MRCUWXFGSA-N icosan-9-yl (z)-docos-13-enoate Chemical compound CCCCCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCCCCCC\C=C/CCCCCCCC VJVOFLWZDWLHNR-MRCUWXFGSA-N 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 201000008482 osteoarthritis Diseases 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 239000012071 phase Substances 0.000 description 48
- -1 viscoelasticity Chemical compound 0.000 description 34
- 210000004027 cell Anatomy 0.000 description 32
- 235000002639 sodium chloride Nutrition 0.000 description 32
- 235000019198 oils Nutrition 0.000 description 26
- 239000000194 fatty acid Substances 0.000 description 23
- 239000011859 microparticle Substances 0.000 description 21
- 239000002245 particle Substances 0.000 description 18
- 125000004432 carbon atom Chemical group C* 0.000 description 17
- 235000014113 dietary fatty acids Nutrition 0.000 description 17
- 229930195729 fatty acid Natural products 0.000 description 17
- 238000002360 preparation method Methods 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- 150000002148 esters Chemical class 0.000 description 15
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 13
- 239000003995 emulsifying agent Substances 0.000 description 13
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 13
- 229920001223 polyethylene glycol Polymers 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 239000004094 surface-active agent Substances 0.000 description 13
- 229940008099 dimethicone Drugs 0.000 description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 description 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 10
- 239000000499 gel Substances 0.000 description 10
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 10
- 229940099552 hyaluronan Drugs 0.000 description 10
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 8
- 150000004665 fatty acids Chemical class 0.000 description 8
- 239000003974 emollient agent Substances 0.000 description 7
- 239000007863 gel particle Substances 0.000 description 7
- 238000005191 phase separation Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 244000063299 Bacillus subtilis Species 0.000 description 6
- 235000014469 Bacillus subtilis Nutrition 0.000 description 6
- 102000003918 Hyaluronan Synthases Human genes 0.000 description 6
- 108090000320 Hyaluronan Synthases Proteins 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 150000001298 alcohols Chemical class 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 150000002191 fatty alcohols Chemical class 0.000 description 6
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 239000007793 ph indicator Substances 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
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- 239000001963 growth medium Substances 0.000 description 5
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- 102000004169 proteins and genes Human genes 0.000 description 5
- 229920006395 saturated elastomer Polymers 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 229960002668 sodium chloride Drugs 0.000 description 5
- 150000003626 triacylglycerols Chemical class 0.000 description 5
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 4
- NHTMVDHEPJAVLT-UHFFFAOYSA-N Isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 description 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 4
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- JVSWJIKNEAIKJW-UHFFFAOYSA-N dimethyl-hexane Natural products CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 description 4
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- RNNBHZYEKNHLKT-UHFFFAOYSA-N isopropylmethylpyrazolyl dimethylcarbamate Chemical compound CC(C)N1N=C(C)C=C1OC(=O)N(C)C RNNBHZYEKNHLKT-UHFFFAOYSA-N 0.000 description 4
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- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/07—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from polymer solutions
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/26—Crosslinking, e.g. vulcanising, of macromolecules of latex
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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Landscapes
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- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07150176.1 | 2007-12-19 | ||
| EP07150176 | 2007-12-19 | ||
| PCT/EP2008/068050 WO2009077620A1 (en) | 2007-12-19 | 2008-12-19 | Crosslinked hyaluronic acid in emulsion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2709824A1 true CA2709824A1 (en) | 2009-06-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2709824A Abandoned CA2709824A1 (en) | 2007-12-19 | 2008-12-19 | Crosslinked hyaluronic acid in emulsion |
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|---|---|
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| EP (2) | EP2222715B1 (enExample) |
| JP (2) | JP5523338B2 (enExample) |
| CN (2) | CN101878230B (enExample) |
| AU (1) | AU2008337407B2 (enExample) |
| CA (1) | CA2709824A1 (enExample) |
| TW (1) | TW200938208A (enExample) |
| WO (2) | WO2009077399A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IT1395392B1 (it) * | 2009-08-27 | 2012-09-14 | Fidia Farmaceutici | Geli viscoelastici come nuovi filler |
| US8367117B2 (en) | 2010-05-10 | 2013-02-05 | The Research Foundation Of State University Of New York | Nanocomposite hyaluronic acid-clay based hydrogels |
| JP5911871B2 (ja) * | 2010-08-31 | 2016-04-27 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 架橋多糖ビーズおよびその生物医学的使用 |
| CN102690847A (zh) * | 2012-04-13 | 2012-09-26 | 华熙福瑞达生物医药有限公司 | 酶切法制备寡聚透明质酸盐的方法及所得寡聚透明质酸盐和其应用 |
| JP2016506909A (ja) * | 2013-01-11 | 2016-03-07 | カービラン セラピューティクス， インコーポレイテッド | ヒアルロン酸を含む安定化組成物 |
| KR101272792B1 (ko) | 2013-03-04 | 2013-06-10 | 주식회사 뉴앤뉴 | 보습성이 우수한 수분크림 |
| CN103333351B (zh) * | 2013-05-02 | 2015-11-25 | 杭州协合医疗用品有限公司 | 一种以透明质酸钠为原料制备可用作栓塞剂的交联透明质酸钠微球的工艺 |
| EP2832378A2 (en) | 2013-08-01 | 2015-02-04 | Ivis Technologies S R L | Adhesive biopolymer for use as a temporary replacement of the epithelium |
| CN103450490A (zh) * | 2013-09-10 | 2013-12-18 | 杭州协合医疗用品有限公司 | 一种以透明质酸钠为原料制备交联透明质酸钠微球凝胶的工艺 |
| US20150283080A1 (en) * | 2014-04-03 | 2015-10-08 | Pankaj Modi | Stabilized dermatological delivery system for active ingredient compositions for topical administration to the skin |
| CN104592420A (zh) * | 2014-12-25 | 2015-05-06 | 上海景峰制药有限公司 | 一种交联玻璃酸钠的中间体ha-vs的制备方法 |
| ITRM20150204A1 (it) * | 2015-05-13 | 2016-11-13 | Nanofaber S R L | Microspugne di acido ialuronico e metodo per la preparazione delle stesse |
| US10130578B2 (en) | 2015-07-23 | 2018-11-20 | Johnson & Johnson Consumer Inc. | Topical delivery of skin compositions having low pH |
| US11021580B2 (en) | 2015-07-27 | 2021-06-01 | Galderma Holding SA | Process for efficient cross-linking of hyaluronic acid |
| EP3320028A1 (en) * | 2015-09-01 | 2018-05-16 | Merz Pharma GmbH & Co. KGaA | Method of making a cross-linked polymer gel and device for performing the method |
| JP6800984B2 (ja) * | 2015-10-05 | 2020-12-16 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 軟骨傷害の検出及び処置のためのマイクロ並びにナノデバイス |
| CN105647675A (zh) * | 2015-12-25 | 2016-06-08 | 上海卫康光学眼镜有限公司 | 一种透明质酸钠弹性体作为接触镜清洁液成分的应用及其制备方法 |
| KR20170090965A (ko) * | 2016-01-29 | 2017-08-08 | 한미약품 주식회사 | 복합 히알루론산 가교물 및 그 제조방법 |
| KR101939880B1 (ko) | 2016-06-29 | 2019-01-18 | 서울대학교산학협력단 | 암병변 선택적 표지를 위한 수화젤 기반 나노 에멀전 및 이의 제조 방법 |
| KR102394532B1 (ko) * | 2016-06-30 | 2022-05-06 | (주)아모레퍼시픽 | 분자량이 상이한 히알루론산들을 함유하는 화장료 조성물 |
| CN107550750B (zh) * | 2016-06-30 | 2021-12-17 | 株式会社爱茉莉太平洋 | 含有不同分子量透明质酸的化妆品组合物 |
| US11851583B2 (en) | 2016-07-19 | 2023-12-26 | Evonik Operations Gmbh | Process for producing porous polyurethane coatings using polyol ester additives |
| KR101901986B1 (ko) * | 2016-11-18 | 2018-09-27 | 서울대학교산학협력단 | 암세포의 선택적 형광 표지를 위한 나노전달체 및 그 제조방법 |
| EP3590545B1 (en) * | 2017-02-28 | 2024-06-26 | CG Bio Co., Ltd. | Composition for injection into skin |
| BR112019017793B1 (pt) * | 2017-02-28 | 2022-12-06 | Cg Bio Co., Ltd. | Composição para injeção dérmica |
| WO2018159984A1 (ko) * | 2017-02-28 | 2018-09-07 | (주)시지바이오 | 피부 주입용 조성물 |
| CN110891611B (zh) | 2017-03-22 | 2024-03-29 | 阿森迪斯制药公司 | 水凝胶交联透明质酸前药组合物和方法 |
| EP3685876B1 (en) * | 2017-09-19 | 2024-04-24 | LG Household & Health Care Ltd. | Hyaluronic acid filler using microneedle patch |
| CN108410926B (zh) * | 2017-12-03 | 2021-12-14 | 新疆阜丰生物科技有限公司 | 一种制备提取高分子量透明质酸的方法 |
| CN108261561B (zh) * | 2018-01-30 | 2021-04-23 | 杭州协合医疗用品有限公司 | 一种可显影透明质酸微球栓塞剂及其制备方法和应用 |
| US20190240335A1 (en) * | 2018-02-07 | 2019-08-08 | Promedon S.A. | Biocompatible Hydrogel Compositions |
| CN108478875B (zh) * | 2018-03-16 | 2021-06-04 | 浙江科技学院 | 一种交联透明质酸凝胶微球的制备方法及其应用 |
| WO2020030629A1 (en) | 2018-08-07 | 2020-02-13 | Merz Pharma Gmbh & Co. Kgaa | Method for dynamic filtration of a cross-linked hydrogel |
| CN110251414A (zh) * | 2019-07-19 | 2019-09-20 | 珠海海狮龙生物科技有限公司 | 一种祛皱膏霜及其制备方法 |
| KR102750812B1 (ko) * | 2019-07-24 | 2025-01-09 | (주)아모레퍼시픽 | 히알루론산 피부 외용제 조성물 |
| KR102501175B1 (ko) * | 2020-02-03 | 2023-02-16 | 엠앤에이치바이오 주식회사 | 난청 치료용 제어 방출형 제제 및 이의 제조방법 |
| KR102162724B1 (ko) * | 2020-03-24 | 2020-10-07 | 바이오플러스 주식회사 | 가교 히알루론산 겔 및 이의 제조 방법 |
| CN113736103A (zh) * | 2020-05-27 | 2021-12-03 | 杭州协合医疗用品有限公司 | 一种目标粒径乳化交联透明质酸钠微粒的富集及交联剂清洗方法 |
| CN111840638B (zh) * | 2020-07-21 | 2022-04-12 | 华熙生物科技股份有限公司 | 一种注射用交联透明质酸填充剂的制备方法 |
| CN111848991B (zh) * | 2020-07-21 | 2022-03-29 | 华熙生物科技股份有限公司 | 一种交联透明质酸微球的制备方法 |
| CN114099771A (zh) * | 2020-08-27 | 2022-03-01 | 杭州协合医疗用品有限公司 | 一种含混合聚合物微球的梯度注射剂 |
| WO2022051060A1 (en) * | 2020-09-01 | 2022-03-10 | Orthogenrx, Inc. | Crosslinking of non-animal-derived hyaluronic acid with divinyl sulfone |
| CN114306109A (zh) * | 2020-09-30 | 2022-04-12 | 赢创运营有限公司 | 用于制备胶束乳液和透明凝胶的组合物 |
| KR102547183B1 (ko) * | 2020-10-19 | 2023-06-26 | 주식회사 메피온 | 필러 및 필러 제조 방법 |
| KR102296304B1 (ko) * | 2020-11-30 | 2021-09-01 | 조광용 | 고팽윤성 히알루론산 비드 겔 제조 방법 |
| KR102577433B1 (ko) * | 2020-12-02 | 2023-09-14 | 주식회사 와이유 | 화장품 용도의 히알루론산 비드 제조 방법 |
| KR102366394B1 (ko) * | 2021-01-05 | 2022-02-23 | 조광용 | 고팽윤성 히알루론산 비드 겔 |
| CN112812197B (zh) * | 2021-01-11 | 2022-05-31 | 中国药科大学 | 一种兰州百合多糖及其制备方法和应用 |
| KR102380762B1 (ko) * | 2021-01-11 | 2022-03-30 | 조광용 | 온도감응성 히알루론산 비드 겔 |
| CA3208574A1 (en) * | 2021-02-16 | 2022-08-25 | Prollenium Medical Technologies, Inc. | Cross-linked ha beads, process for making same and uses |
| CN113244456A (zh) * | 2021-05-31 | 2021-08-13 | 美卓(杭州)医疗科技有限公司 | 一种用于眼周抗衰的活性填充剂及其制备方法 |
| CN113388168B (zh) * | 2021-07-19 | 2022-12-09 | 苏州快乐猩球生物科技有限公司 | 一种透明质酸纳米微球复合物、制备方法及应用 |
| CN114644763B (zh) * | 2022-03-21 | 2024-05-28 | 江南大学 | 一种两亲性热凝胶包埋丁香油的Pickering乳液及其制备方法 |
| KR102764599B1 (ko) * | 2022-04-21 | 2025-02-11 | 주식회사 메피온 | 약물 전달체 및 그 제조 방법 |
| CN115844769B (zh) * | 2022-12-26 | 2024-11-12 | 上海家化联合股份有限公司 | 含有油凝珠组合物的稳定乳化体系 |
| CN116898756B (zh) * | 2022-12-31 | 2025-08-05 | 创庭生物科技(上海)有限公司 | 一种含油相分散透明质酸钠高效保湿唇膏及其制备方法 |
| CN115737912B (zh) * | 2023-01-09 | 2023-04-28 | 云南云科特色植物提取实验室有限公司 | 一种具有缓释效果的透明质酸微球复合溶液制剂的制备方法 |
| FR3151481A1 (fr) | 2023-07-28 | 2025-01-31 | Horus Pharma | Emulsion de type huile dans eau comprenant de l’acide hyaluronique et du dexpanthenol |
| CN117018288B (zh) * | 2023-07-28 | 2025-10-03 | 四川大学 | 一种注射用透明质酸微球的制备方法 |
| CN118160929B (zh) * | 2024-01-25 | 2025-11-28 | 宁波大学 | 一种用于包埋乳酸菌的纳米微胶囊及其应用 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1165574B (de) | 1960-08-08 | 1964-03-19 | Dehydag Gmbh | Verfahren zur Herstellung von als Emulgiermittel fuer Salbengrundlagen dienenden Mischestern |
| US4478853A (en) * | 1982-05-17 | 1984-10-23 | S. C. Johnson & Son, Inc. | Skin conditioning composition |
| US4716224A (en) | 1984-05-04 | 1987-12-29 | Seikagaku Kogyo Co. Ltd. | Crosslinked hyaluronic acid and its use |
| JPS60251898A (ja) | 1984-05-25 | 1985-12-12 | Shiseido Co Ltd | 醗酵法によるヒアルロン酸の製造方法 |
| US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| US4713448A (en) | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
| IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| DE3740186A1 (de) | 1987-06-24 | 1989-01-05 | Beiersdorf Ag | Desodorierende und antimikrobielle zusammensetzung zur verwendung in kosmetischen oder topischen zubereitungen |
| US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US5356883A (en) | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
| DE3938140A1 (de) | 1989-11-16 | 1991-08-08 | Beiersdorf Ag | Desodorierende kosmetische mittel |
| DE4009347A1 (de) | 1990-03-23 | 1991-09-26 | Beiersdorf Ag | Desodorierende kosmetische mittel |
| JPH05198768A (ja) | 1992-01-21 | 1993-08-06 | Mitsubishi Electric Corp | 半導体記憶装置およびその製造方法 |
| DE4204321A1 (de) | 1992-02-13 | 1993-08-19 | Beiersdorf Ag | Verfahren zur isolierung und reinigung von fettsaeuren und hydroxyfettsaeuren und verwendungen von hydroxyfettsaeuren sowie zubereitungen, die sie enthalten |
| DE4229737C2 (de) | 1992-09-05 | 1996-04-25 | Beiersdorf Ag | Desodorierende kosmetische Mittel mit einem Gehalt an Fettsäuren |
| DE4229707A1 (de) | 1992-09-05 | 1994-03-10 | Beiersdorf Ag | Germicide Wirkstoffkombinationen |
| DE4237081C2 (de) | 1992-11-03 | 1996-05-09 | Beiersdorf Ag | Verwendung von Di- oder Triglycerinestern als Deowirkstoffe |
| DE4309372C2 (de) | 1993-03-23 | 1997-08-21 | Beiersdorf Ag | Kosmetische Desodorantien, enthaltend Gemische aus Wollwachssäuren oder Wollwachssäurekomponenten und Fettsäurepartialglyceriden unverzweigter Fettsäuren |
| DE4324219C2 (de) | 1993-07-20 | 1995-08-10 | Beiersdorf Ag | Desodorierende Wirkstoffkombinationen auf der Basis von alpha, omega-Alkandicarbonsäuren und Wollwachssäuren |
| IT1271001B (it) | 1994-07-26 | 1997-05-26 | Poli Ind Chimica Spa | Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus |
| EP0830416B1 (en) | 1995-06-06 | 2005-08-31 | C.R. Bard, Inc. | Process for the preparation of crosslinked particles of water soluble polymers, the particles obtained and their use |
| US6214331B1 (en) * | 1995-06-06 | 2001-04-10 | C. R. Bard, Inc. | Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained |
| US7276251B2 (en) * | 1997-04-01 | 2007-10-02 | Lg Life Sciences, Ltd., Inc. | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid |
| DE19641604C1 (de) * | 1996-10-09 | 1998-03-12 | Goldschmidt Ag Th | Polyglycerinpartialester von Fettsäuren und mehrfunktionellen Carbonsäuren, deren Herstellung und Verwendung |
| DE69723855T2 (de) | 1996-11-18 | 2004-06-03 | Novozymes Biotech, Inc., Davis | Verfahren zur herstellung von polypeptiden in surfaktinmutanten von bacillus zellen |
| US5891701A (en) | 1997-06-12 | 1999-04-06 | Novo Nordisk Biotech Inc. | Nucleic acids encoding a polypeptide having protease activity |
| CN1322121C (zh) | 1997-10-31 | 2007-06-20 | 俄克拉何马大学董事会 | 透明质酸合酶基因及其应用 |
| JP4490581B2 (ja) | 1998-04-02 | 2010-06-30 | ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ | ヒアルロナンシンターゼをコードする核酸およびその使用方法 |
| DE69940353D1 (en) | 1998-11-11 | 2009-03-12 | Univ Oklahoma | Polymerpfropfung mittels polysaccharide-synthase |
| DE19855934A1 (de) | 1998-12-04 | 2000-06-08 | Beiersdorf Ag | Verwendung von Betainen als Antitranspirantien |
| JP2000248002A (ja) * | 1999-02-19 | 2000-09-12 | Denki Kagaku Kogyo Kk | 自己架橋ヒアルロン酸とその製造方法及びその用途 |
| US6521223B1 (en) * | 2000-02-14 | 2003-02-18 | Genzyme Corporation | Single phase gels for the prevention of adhesions |
| AU2002239697A1 (en) * | 2000-10-24 | 2002-06-03 | Clear Solutions Biotech, Inc. | Sodium hyaluronate microspheres |
| TW574301B (en) * | 2001-05-02 | 2004-02-01 | Ind Tech Res Inst | Manufacturing method of epoxide crosslinked polysaccharides matrix |
| DE60239495D1 (de) | 2001-12-21 | 2011-04-28 | Novozymes Biopharma Dk As | Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelle |
| ITPD20020064A1 (it) * | 2002-03-12 | 2003-09-12 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
| US20050222081A1 (en) | 2002-04-17 | 2005-10-06 | Gianolio Diego A | Cross-linked hyaluronate compounds |
| WO2004067575A1 (en) | 2003-01-31 | 2004-08-12 | Biosphere S.P.A. | Water soluble and biocompatible gels of hyaluronic acid cross-linked with bi-functional l-aminoacids or l-aminoesters |
| EP1504747B1 (en) * | 2003-08-08 | 2005-10-19 | KPSS-Kao Professional Salon Services GmbH | Cosmetic composition for hair comprising cetyl PEG/PPG-10/1 dimethicone and ceramide |
| US7601704B2 (en) * | 2003-11-03 | 2009-10-13 | University Of North Texas | Process for synthesizing oil and surfactant-free hyaluronic acid nanoparticles and microparticles |
| US8575332B2 (en) * | 2003-11-14 | 2013-11-05 | Chugai Seiyaku Kabushiki Kaisha | Crosslinked polysaccharide microparticles and method for their preparation |
| US7544714B2 (en) * | 2004-07-16 | 2009-06-09 | University Of Massachusetts | Lipid-amino acid conjugates and methods of use |
| EP1817347B1 (en) | 2004-11-24 | 2017-05-17 | Albumedix A/S | Method of cross-linking hyaluronic acid with divinylsulfone |
| KR100852944B1 (ko) | 2007-02-15 | 2008-08-19 | (주)아모레퍼시픽 | 화학적으로 가교된 히알루론산 하이드로겔 나노입자의제조방법 |
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| US9109051B2 (en) | 2015-08-18 |
| EP2222715B1 (en) | 2019-07-24 |
| JP2011506719A (ja) | 2011-03-03 |
| JP2011506734A (ja) | 2011-03-03 |
| TW200938208A (en) | 2009-09-16 |
| JP5523338B2 (ja) | 2014-06-18 |
| AU2008337407B2 (en) | 2013-09-05 |
| CN101952325A (zh) | 2011-01-19 |
| US20120258155A1 (en) | 2012-10-11 |
| AU2008337407A1 (en) | 2009-06-25 |
| US20100266512A1 (en) | 2010-10-21 |
| EP2222715A1 (en) | 2010-09-01 |
| US20100311963A1 (en) | 2010-12-09 |
| EP2225281A1 (en) | 2010-09-08 |
| WO2009077399A1 (en) | 2009-06-25 |
| CN101878230B (zh) | 2012-11-21 |
| CN101878230A (zh) | 2010-11-03 |
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