|
US6608197B2
(en)
*
|
2000-01-25 |
2003-08-19 |
Neurocrine Biosciences, Inc. |
Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
|
|
EP1646389B1
(en)
*
|
2003-07-07 |
2008-09-10 |
Neurocrine Biosciences, Inc. |
Pyrimidine-2,4-dione derivatives as gonadotropin-releasing hormone receptor antagonists
|
|
JP4673847B2
(ja)
*
|
2003-07-07 |
2011-04-20 |
ニューロクライン バイオサイエンシーズ，インコーポレイテッド |
性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法
|
|
BRPI0412327A
(pt)
*
|
2003-07-07 |
2006-09-05 |
Neurocrine Biosciences Inc |
derivados de pirimidina-2,4-diona como antagonistas de receptor de hormÈnio liberador de gonadotropina
|
|
CN102079743B
(zh)
*
|
2004-03-15 |
2020-08-25 |
武田药品工业株式会社 |
二肽基肽酶抑制剂
|
|
MX2009010828A
(es)
|
2007-04-06 |
2009-10-29 |
Neurocrine Biosciences Inc |
Antagonistas del receptor de la hormona liberadora de gonadotropina y metodos relacionados con los mismos.
|
|
CL2008000986A1
(es)
|
2007-04-06 |
2008-10-17 |
Neurocrine Biosciences Inc |
COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV
|
|
US20090136465A1
(en)
|
2007-09-28 |
2009-05-28 |
Intrexon Corporation |
Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
|
|
US8765948B2
(en)
*
|
2007-11-07 |
2014-07-01 |
Neurocrine Biosciences, Inc. |
Processes for the preparation of uracil derivatives
|
|
JP5757956B2
(ja)
*
|
2009-11-20 |
2015-08-05 |
エスケー ケミカルス シーオー．， エルティーディー．Ｓｋ Ｃｈｅｍｉｃａｌｓ Ｃｏ．， Ｌｔｄ． |
ゴナドトロピン放出ホルモン受容体拮抗剤、その製造方法及びそれを含む医薬組成物
|
|
EP4223298A3
(en)
|
2013-03-15 |
2023-08-16 |
AbbVie Inc. |
Compositions for use in treating heavy menstrual bleeding
|
|
EP2881391A1
(en)
|
2013-12-05 |
2015-06-10 |
Bayer Pharma Aktiengesellschaft |
Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof
|
|
AU2015308987B2
(en)
|
2014-08-26 |
2021-02-18 |
Kaass Discovery As |
Methods, agents and compositions for treatment of inflammatory conditions
|
|
US20190321363A1
(en)
*
|
2016-06-20 |
2019-10-24 |
Dr. Reddy's Laboratories Limited |
Process for the preparation of elagolix sodium and its polymorph
|
|
WO2018015497A2
(en)
|
2016-07-21 |
2018-01-25 |
ObsEva S.A. |
Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
|
|
KR102458763B1
(ko)
|
2016-08-23 |
2022-10-26 |
스완 아날라이티쉐 인스트루멘테 아크티엔게젤샤프트 |
액체의 전기 탈이온화 장치 및 방법
|
|
WO2018060501A2
(en)
|
2016-09-30 |
2018-04-05 |
Myovant Sciences Gmbh |
Methods of treating uterine fibroids and endometriosis
|
|
SI3518932T1
(sl)
|
2016-09-30 |
2025-03-31 |
Takeda Pharmaceutical Company Limited |
Zdravljenje raka prostate
|
|
CA3038865A1
(en)
|
2016-09-30 |
2018-04-05 |
Myovant Sciences Gmbh |
Methods of treating female infertility
|
|
WO2018111990A1
(en)
|
2016-12-14 |
2018-06-21 |
Purdue Research Foundation |
Luteinizing hormone-releasing hormone receptor (lhrh-r) conjugates and uses thereof
|
|
AU2018251951B2
(en)
|
2017-04-12 |
2020-09-03 |
Sandoz Ag |
Acid addition salts of an orally available gonadotropin-releasing hormone receptor antagonist
|
|
EP3388421B1
(en)
|
2017-04-13 |
2019-12-04 |
Sandoz AG |
Acid addition salts of an orally available gonadotropin-releasing hormone receptor antagonist
|
|
PT3388422T
(pt)
|
2017-04-13 |
2020-02-18 |
Sandoz Ag |
Dispersão sólida amorfa de um antagonista dos recetores de hormonas libertadoras de gonadotrofina disponível por via oral
|
|
WO2018198086A1
(en)
*
|
2017-04-28 |
2018-11-01 |
Lupin Limited |
Process for the preparation of elagolix and pharmaceutically acceptable salts thereof
|
|
EA201992612A1
(ru)
|
2017-06-05 |
2020-05-20 |
Обсева С.А. |
Схемы применения антагониста гонадотропин-высвобождающего гормона для лечения эндометриоза
|
|
WO2018224063A2
(en)
*
|
2017-06-08 |
2018-12-13 |
Zentiva, K.S. |
Solid forms of elagolix
|
|
TW201919632A
(zh)
*
|
2017-08-18 |
2019-06-01 |
美商艾伯維有限公司 |
治療子宮內膜異位症、子宮纖維瘤、多囊性卵巢症候群或子宮腺肌症之醫藥調配物
|
|
TW201912157A
(zh)
|
2017-08-18 |
2019-04-01 |
美商艾伯維有限公司 |
治療子宮內膜異位症、子宮纖維瘤、多囊性卵巢症候群及子宮腺肌症之固體醫藥調配物
|
|
SG11202001436YA
(en)
|
2017-08-18 |
2020-03-30 |
Abbvie Inc |
Pharmaceutical formulations for treating endometriosis, uterine fibroids, polycystic ovary syndrome or adenomyosis
|
|
CN107935863A
(zh)
*
|
2017-11-30 |
2018-04-20 |
厦门海乐景生化有限公司 |
Elagolix的关键原料化合物C的合成方法
|
|
CN110938037A
(zh)
*
|
2018-09-21 |
2020-03-31 |
苏州鹏旭医药科技有限公司 |
一种依拉戈利钠盐药物中间体的制备方法
|
|
WO2019112968A1
(en)
|
2017-12-05 |
2019-06-13 |
Peng Wang |
Processes to produce elagolix
|
|
WO2019115019A1
(en)
|
2017-12-11 |
2019-06-20 |
Synthon B.V. |
Process for preparing elagolix
|
|
CN109970663B
(zh)
*
|
2017-12-27 |
2023-04-11 |
上海科胜药物研发有限公司 |
一种制备噁拉戈利中间体的方法
|
|
CN108129400B
(zh)
*
|
2017-12-29 |
2021-10-15 |
安帝康（无锡）生物科技有限公司 |
氘代噁拉戈利衍生物及其用途
|
|
US11690854B2
(en)
|
2018-04-19 |
2023-07-04 |
Abbvie Inc. |
Methods of treating heavy menstrual bleeding
|
|
CN110669013A
(zh)
*
|
2018-07-03 |
2020-01-10 |
江苏海悦康医药科技有限公司 |
一种噁拉戈利中间体的制备方法
|
|
WO2020023459A1
(en)
|
2018-07-23 |
2020-01-30 |
Abbvie Inc. |
Elagolix sodium compositions and processes
|
|
CA3107597A1
(en)
*
|
2018-08-01 |
2020-02-06 |
Abbvie Inc. |
Dosing regimens for elagolix
|
|
EP3572406A1
(en)
|
2018-10-17 |
2019-11-27 |
Sandoz Ag |
Acid addition salt of elagolix and related compounds
|
|
MA54058A
(fr)
|
2018-10-29 |
2021-09-08 |
ObsEva SA |
Compositions et méthodes de traitement de l'endométriose interne et de l'endométriose rectovaginale
|
|
JP7459086B2
(ja)
|
2018-11-07 |
2024-04-01 |
キッセイ薬品工業株式会社 |
エストロゲン依存性障害の治療のための組成物及び方法
|
|
CN109293634A
(zh)
*
|
2018-12-04 |
2019-02-01 |
中国药科大学 |
恶拉戈利杂质的制备方法
|
|
CN109651171A
(zh)
*
|
2019-01-13 |
2019-04-19 |
苏州鹏旭医药科技有限公司 |
依拉戈利及其钠盐的中间体及其盐的制备方法和应用
|
|
JP2022518019A
(ja)
|
2019-01-15 |
2022-03-11 |
ルパン インコーポレイテッド |
重水素化エラゴリクス様組成物及び方法
|
|
CN109810065B
(zh)
*
|
2019-02-16 |
2022-07-15 |
安徽华胜医药科技有限公司 |
一种恶拉戈利的合成方法
|
|
CN109651265A
(zh)
*
|
2019-02-16 |
2019-04-19 |
安徽诺全药业有限公司 |
一种Elagolix的制备方法
|
|
CN109761913A
(zh)
*
|
2019-02-16 |
2019-05-17 |
安徽华胜医药科技有限公司 |
一种有机金属钯催化合成elagolix中间体的方法
|
|
CN110041232A
(zh)
*
|
2019-04-10 |
2019-07-23 |
丽珠集团新北江制药股份有限公司 |
一种制备GnRHR药物关键中间体化合物的方法
|
|
CN109956906B
(zh)
*
|
2019-04-19 |
2021-01-29 |
奥锐特药业股份有限公司 |
一种噁拉戈利关键中间体的制备方法
|
|
US20220242831A1
(en)
*
|
2019-05-24 |
2022-08-04 |
Dr. Reddy's Laboratories Limited |
Improved process for the preparation of elagolix and its intermediates
|
|
CN110204498B
(zh)
*
|
2019-06-14 |
2020-11-27 |
奥锐特药业股份有限公司 |
一种高效合成噁拉戈利中间体的方法
|
|
CN110372608A
(zh)
*
|
2019-07-09 |
2019-10-25 |
丽珠集团新北江制药股份有限公司 |
一种促性腺激素释放激素拮抗剂的制备方法
|
|
ES2802815B2
(es)
|
2019-07-12 |
2022-03-14 |
Moehs Iberica Sl |
Sal clorhidrato de 3-[2(r)-amino-2-feniletil]-5-(2-fluoro-3-metoxifenil)-1-[2-fluoro-6-(trifluorometil)bencil]-6-metil-1h-pirimidin-2,4(1h,3h)-diona (i) en forma solida, procedimiento para su preparacion y uso de la misma en la sintesis de elagolix
|
|
CN110372609B
(zh)
*
|
2019-07-25 |
2021-04-09 |
奥锐特药业股份有限公司 |
一种噁拉戈利钠盐的纯化方法
|
|
CN112672998B
(zh)
*
|
2019-07-31 |
2022-06-21 |
深圳仁泰医药科技有限公司 |
恶拉戈利与乙胺嘧啶的共晶型a及其制备方法和用途
|
|
EP4009976A1
(en)
|
2019-08-08 |
2022-06-15 |
ObsEva S.A. |
Gnrh antagonists for the treatment of estrogen-dependent disorders
|
|
AU2020325655B2
(en)
|
2019-08-08 |
2025-09-11 |
Kissei Pharmaceutical Co., Ltd. |
Compositions and methods for the treatment of estrogen-dependent disorders
|
|
IT202000001390A1
(it)
*
|
2020-01-24 |
2021-07-24 |
Ind Chimica Srl |
Processo per la preparazione del sale sodico dell’acido 4-[[(1r)-2-[5-(2-fluoro-3-metossifenil)-3-[[2-fluoro-6-(trifluorometil)fenil]metil]-3,6-diidro-4-metil-2,6-diosso-1(2h)-pirimidinil]-1-feniletil]ammino]-butanoico (elagolix sale sodico) e intermedi di detto processo
|
|
IT201900015458A1
(it)
*
|
2019-09-03 |
2021-03-03 |
Ind Chimica Srl |
Processo per la preparazione del sale sodico dell’acido 4-[[(1r)-2-[5-(2-fluoro-3-metossifenil)-3-[[2-fluoro-6-(trifluorometil)fenil]metil]-3,6-diidro-4-metil-2,6-diosso-1(2h)-pirimidinil]-1-feniletil]ammino]-butanoico (elagolix sale sodico) e intermedi di detto processo
|
|
US20220323410A1
(en)
|
2019-09-03 |
2022-10-13 |
ObsEva S.A. |
Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
|
|
ES2915123B2
(es)
*
|
2019-09-03 |
2024-04-24 |
Ind Chimica Srl |
Proceso para la síntesis de la sal sódica del ácido 4-[[(1R)-2-[5-(2-fluoro-3-metoxifenil)-3-[[2-fluoro-6-(trifluorometil)-fenil]metil]-3,6-dihidro-4-metil-2,6-dioxo-1(2H)-pirimidinil]-1-feniletil]amino]-butanoico (sal sódica de Elagolix) y productos intermedios de dicho proceso
|
|
TWI755055B
(zh)
*
|
2019-09-18 |
2022-02-11 |
台灣神隆股份有限公司 |
用於製備惡拉戈利鈉及其中間體的方法
|
|
WO2021064561A1
(en)
*
|
2019-10-03 |
2021-04-08 |
Neuland Laboratories Limited |
An improved process for the preparation of elagolix sodium
|
|
CN112694445B
(zh)
*
|
2019-10-22 |
2023-07-28 |
成都倍特药业股份有限公司 |
一种噁拉戈利钠中间体的纯化方法
|
|
ES2822398B2
(es)
|
2019-10-30 |
2022-03-02 |
Moehs Iberica Sl |
3-((R)-2-(Amino-2-feniletil)-1-(2-fluoro-6-trifluorometilbencil)-5-yodo-6-metil-1H-pirimidin-2,4-diona o una sal de la misma, procedimiento para su preparación y su uso en la síntesis de elagolix
|
|
WO2021130776A1
(en)
*
|
2019-12-27 |
2021-07-01 |
Msn Laboratories Private Limited, R&D Center |
An improved process for the preparation of 4-({(1 r)-2-[5-(2-fluoro-3methoxyphenyl)-3-{[2-fluoro-6-(trifluoro methyl) phenyl]methyl}-4-methyl-2,6-dioxo-3,6dihydropyrimidin-1(2 h)-yl]-1-phenylethyl}amino)butanoic acid or its pharmaceutically acceptable salts
|
|
CN113125575B
(zh)
*
|
2019-12-31 |
2023-04-18 |
济南尚博生物科技有限公司 |
一种1-(2-氟-6-(三氟甲基)苄基)-6-甲基嘧啶-二酮的定量分析方法
|
|
CN111116490A
(zh)
*
|
2020-01-15 |
2020-05-08 |
奥锐特药业股份有限公司 |
一种噁拉戈利中间体水杨酸盐的制备与纯化方法
|
|
CN115380122A
(zh)
|
2020-02-10 |
2022-11-22 |
奥布赛瓦股份公司 |
用于催产素受体拮抗剂疗法的生物标志物
|
|
CN115515592A
(zh)
*
|
2020-03-05 |
2022-12-23 |
艾伯维公司 |
施用恶拉戈利的方法
|
|
WO2021180862A1
(en)
|
2020-03-12 |
2021-09-16 |
Synthon B.V. |
Pharmaceutical compositions comprising elagolix sodium
|
|
CN111333548B
(zh)
*
|
2020-04-10 |
2022-04-26 |
江苏海悦康医药科技有限公司 |
1-(2-氟-6-(三氟甲基)苄基)脲的制备方法
|
|
CN113527213B
(zh)
*
|
2020-04-20 |
2023-01-03 |
上海英诺富成生物科技有限公司 |
促性激素释放激素受体拮抗剂及其用途
|
|
CN113683572A
(zh)
*
|
2020-05-18 |
2021-11-23 |
陈晓雯 |
噁拉戈利的中间体及其制备方法和应用
|
|
BR112022023937A2
(pt)
|
2020-05-29 |
2022-12-27 |
Myovant Sciences Gmbh |
Formas de dosagem oral sólidas de combinação de antagonistas do hormônio liberador de gonadotropina
|
|
CN113880773A
(zh)
*
|
2020-07-02 |
2022-01-04 |
南京药石科技股份有限公司 |
一种噁拉戈利中间体的制备方法
|
|
CN112457258A
(zh)
*
|
2020-11-26 |
2021-03-09 |
诚达药业股份有限公司 |
一种噁拉戈利钠及其中间体的制备方法
|
|
CA3208983A1
(en)
|
2021-01-29 |
2022-08-04 |
Abbvie Inc. |
Methods of administering elagolix
|
|
KR102656087B1
(ko)
|
2024-01-12 |
2024-04-09 |
주식회사 씨엠지 |
Led 소자의 에폭시 수지 코팅층 형성 방법
|
|
WO2026018221A1
(en)
|
2024-07-18 |
2026-01-22 |
ReproNovo SA |
Crystalline compositions for improving embryo implantation and methods of using the same
|