JP2010535252A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010535252A5 JP2010535252A5 JP2010520219A JP2010520219A JP2010535252A5 JP 2010535252 A5 JP2010535252 A5 JP 2010535252A5 JP 2010520219 A JP2010520219 A JP 2010520219A JP 2010520219 A JP2010520219 A JP 2010520219A JP 2010535252 A5 JP2010535252 A5 JP 2010535252A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- diabetes
- type
- metabolic
- nachr agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95361407P | 2007-08-02 | 2007-08-02 | |
| US95361307P | 2007-08-02 | 2007-08-02 | |
| US95361007P | 2007-08-02 | 2007-08-02 | |
| US97165407P | 2007-09-12 | 2007-09-12 | |
| PCT/US2008/071893 WO2009018511A2 (en) | 2007-08-02 | 2008-08-01 | Alpha7 nachr agonists for treating or preventing metabolic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010535252A JP2010535252A (ja) | 2010-11-18 |
| JP2010535252A5 true JP2010535252A5 (enExample) | 2011-01-06 |
Family
ID=39945177
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520219A Pending JP2010535252A (ja) | 2007-08-02 | 2008-08-01 | 代謝障害を治療または予防するためのα7nAChRアゴニスト |
| JP2010520213A Active JP5358573B2 (ja) | 2007-08-02 | 2008-08-01 | (2s,3r)−n−(2−((3−ピリジニル)メチル)−1−アザビシクロ[2.2.2]オクタ−3−イル)ベンゾフラン−2−カルボキサミド、その新規塩形態およびその使用方法 |
| JP2013148087A Active JP5852611B2 (ja) | 2007-08-02 | 2013-07-17 | (2s,3r)−n−(2−((3−ピリジニル)メチル)−1−アザビシクロ[2.2.2]オクタ−3−イル)ベンゾフラン−2−カルボキサミド、その新規塩形態およびその使用方法 |
| JP2013148091A Active JP6106549B2 (ja) | 2007-08-02 | 2013-07-17 | (2s,3r)−n−(2−((3−ピリジニル)メチル)−1−アザビシクロ[2.2.2]オクタ−3−イル)ベンゾフラン−2−カルボキサミド、その新規塩形態およびその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520213A Active JP5358573B2 (ja) | 2007-08-02 | 2008-08-01 | (2s,3r)−n−(2−((3−ピリジニル)メチル)−1−アザビシクロ[2.2.2]オクタ−3−イル)ベンゾフラン−2−カルボキサミド、その新規塩形態およびその使用方法 |
| JP2013148087A Active JP5852611B2 (ja) | 2007-08-02 | 2013-07-17 | (2s,3r)−n−(2−((3−ピリジニル)メチル)−1−アザビシクロ[2.2.2]オクタ−3−イル)ベンゾフラン−2−カルボキサミド、その新規塩形態およびその使用方法 |
| JP2013148091A Active JP6106549B2 (ja) | 2007-08-02 | 2013-07-17 | (2s,3r)−n−(2−((3−ピリジニル)メチル)−1−アザビシクロ[2.2.2]オクタ−3−イル)ベンゾフラン−2−カルボキサミド、その新規塩形態およびその使用方法 |
Country Status (35)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| SA08290475B1 (ar) * | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| EP2647373A1 (en) * | 2008-05-12 | 2013-10-09 | Targacept, Inc. | Methods for preventing the development of retinopathy by the oral administration of exo-S-mecamylamine. |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| JP5749797B2 (ja) | 2010-05-17 | 2015-07-15 | フォルム ファーマシューティカルズ、インコーポレイテッド | (r)−7−クロロ−n−(キヌクリジン−3−イル)ベンゾ[b]チオフェン−2−カルボキサミド塩酸塩一水和物の結晶形 |
| RU2013108223A (ru) * | 2010-07-26 | 2014-09-10 | Энвиво Фармасьютикалз, Инк. | Лечение когнитивных нарушений определенными агонистами рецептора никотиновой кислоты альфа-7 в сочетании с ингибиторами ацетилхолинэстеразы |
| CA2809675A1 (en) | 2010-09-23 | 2012-03-29 | Shuang Chen | Monohydrate of an azaadamantane derivative |
| TW201242600A (en) * | 2011-01-18 | 2012-11-01 | Targacept Inc | Treatment of cognitive dysfunction in schizophrenia |
| US20140171448A1 (en) | 2011-01-27 | 2014-06-19 | Novartis Ag | Use of nicotinic acetylcholine receptor alpha 7 activators |
| PL3156056T3 (pl) | 2011-03-18 | 2024-04-29 | Alkermes Pharma Ireland Limited | Kompozycje farmaceutyczne zawierające estry sorbitanu |
| US20140228398A1 (en) | 2011-03-18 | 2014-08-14 | Novartis Ag | COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE |
| WO2012129262A1 (en) * | 2011-03-23 | 2012-09-27 | Targacept, Inc. | Treatment of attention deficit/hyperactivity disease |
| JPWO2013002365A1 (ja) | 2011-06-30 | 2015-02-23 | 東レ株式会社 | 止痒剤 |
| TW201311698A (zh) * | 2011-08-22 | 2013-03-16 | Targacept Inc | 作為神經元菸鹼乙醯膽鹼受體配位體之1,4-二氮雜雙環[3.2.2]壬烷 |
| BR112014007485B1 (pt) | 2011-10-20 | 2022-05-31 | Novartis Ag | Métodos para prever responsividade terapêutica de um indivíduo a tratamento com um ativador do receptor de acetilcolina nicotínico alfa 7, e usos do referido ativador |
| NZ630703A (en) * | 2012-03-19 | 2017-02-24 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising glycerol esters |
| JP6333802B2 (ja) | 2012-03-19 | 2018-05-30 | アルカームス ファーマ アイルランド リミテッド | ベンジルアルコールを含む医薬組成物 |
| JP6471089B2 (ja) | 2012-03-19 | 2019-02-13 | アルカームス ファーマ アイルランド リミテッド | 脂肪酸エステルを含む医薬組成物 |
| CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| AU2013349388B2 (en) | 2012-09-19 | 2018-06-28 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
| CN104837499B (zh) | 2012-12-11 | 2018-02-23 | 诺华有限公司 | 预测对α7烟碱型乙酰胆碱受体激活剂治疗响应性的生物标志物 |
| JP6137336B2 (ja) | 2013-01-15 | 2017-05-31 | ノバルティス アーゲー | ナルコレプシーの処置のためのアルファ7ニコチン性受容体アゴニストの使用 |
| US20150313884A1 (en) | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| WO2014111837A1 (en) | 2013-01-15 | 2014-07-24 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| CA2898080C (en) | 2013-01-15 | 2018-01-09 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
| WO2014153424A1 (en) * | 2013-03-19 | 2014-09-25 | La Jolla Institute For Allergy And Immunology | Reducing diabetes in patients receiving hmg-coa reductase inhibitors (statins) |
| RU2688233C2 (ru) | 2014-03-20 | 2019-05-21 | Алкермес Фарма Айэленд Лимитед | Препараты арипипразола, имеющие повышенные скорости впрыска |
| AU2015240465B2 (en) | 2014-04-04 | 2020-02-27 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| CN104288771B (zh) * | 2014-09-30 | 2017-03-15 | 郑州大学第五附属医院 | α7nAChR激动剂的新用途 |
| US10857140B2 (en) | 2015-05-06 | 2020-12-08 | The Regents Of The University Of California | K-Ras modulators |
| US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
| US10282666B1 (en) | 2015-11-10 | 2019-05-07 | Google Llc | Coherency detection and information management system |
| RU2675111C2 (ru) * | 2017-03-31 | 2018-12-17 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фундаментальной и клинической иммунологии" | Способ стимуляции нейрогенеза в гиппокампе |
| AU2018255413A1 (en) | 2017-04-20 | 2019-12-05 | Leidos Biomedical Research, Inc. | K-Ras modulators |
| AU2019230014B2 (en) | 2018-03-05 | 2024-11-28 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
Family Cites Families (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4203990A (en) | 1979-04-30 | 1980-05-20 | G. D. Searle & Co. | Anti-diarrheal 2-substituted quinuclidines |
| EP0353189B1 (de) | 1988-07-28 | 1994-01-12 | Ciba-Geigy Ag | Kupfer- und Nickeldihalogenidkomplexe, Verfahren zu deren Herstellung und deren Verwendung |
| US4922901A (en) | 1988-09-08 | 1990-05-08 | R. J. Reynolds Tobacco Company | Drug delivery articles utilizing electrical energy |
| EP0402056A3 (en) | 1989-06-06 | 1991-09-04 | Beecham Group p.l.c. | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| EP0412798A3 (en) | 1989-08-08 | 1992-07-01 | Merck Sharp & Dohme Ltd. | Substituted pyridines, their preparation, formulations and use in dementia |
| IN173570B (enExample) | 1989-11-23 | 1994-06-04 | Pfizer | |
| DK40890D0 (da) | 1990-02-16 | 1990-02-16 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
| EP0492903A1 (en) | 1990-12-21 | 1992-07-01 | MERCK SHARP & DOHME LTD. | Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma |
| KR0175638B1 (ko) | 1991-03-01 | 1999-02-18 | 카렌 에이.홀브루크 | 신경계 퇴행성 질환 치료용 니코틴 아날로그의 개량된 제조방법 |
| US5212188A (en) | 1992-03-02 | 1993-05-18 | R. J. Reynolds Tabacco Company | Method for treatment of neurodegenerative diseases |
| US5276043A (en) | 1992-04-10 | 1994-01-04 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| KR100272614B1 (ko) | 1992-08-31 | 2000-11-15 | 엠. 잭 오해니언 | 신경계의 퇴행성 질환의 치료에 유용한 아나바세인 유도체 |
| US5977144A (en) | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
| IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
| US5852041A (en) | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
| IL109451A0 (en) * | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
| AU7474794A (en) | 1993-07-22 | 1995-02-20 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
| US5493026A (en) | 1993-10-25 | 1996-02-20 | Organix, Inc. | Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders |
| US5510355A (en) | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
| US5998404A (en) | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
| US5604231A (en) | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
| US5824692A (en) | 1995-01-06 | 1998-10-20 | Lippiello; Patrick Michael | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5597919A (en) | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5616707A (en) | 1995-01-06 | 1997-04-01 | Crooks; Peter A. | Compounds which are useful for prevention and treatment of central nervous system disorders |
| WO1996025160A1 (en) | 1995-02-17 | 1996-08-22 | Novo Nordisk A/S | The use of heterocyclic compounds |
| US5585388A (en) | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| IL118279A (en) | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
| JPH11508540A (ja) | 1995-06-29 | 1999-07-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の置換アザ環式またはアザ二環式化合物 |
| JPH11512443A (ja) | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
| US5712270A (en) | 1995-11-06 | 1998-01-27 | American Home Products Corporation | 2-arylamidothiazole derivatives with CNS activity |
| US5616716A (en) | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
| SE9600683D0 (sv) * | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| US5663356A (en) | 1996-04-23 | 1997-09-02 | Ruecroft; Graham | Method for preparation of aryl substituted alefinic secondary amino compounds |
| US5726189A (en) | 1996-05-03 | 1998-03-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes |
| ZA9711092B (en) | 1996-12-11 | 1999-07-22 | Smithkline Beecham Corp | Novel compounds. |
| US5861423A (en) | 1997-02-21 | 1999-01-19 | Caldwell; William Scott | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
| US5811442A (en) | 1997-02-21 | 1998-09-22 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow |
| KR100589872B1 (ko) | 1997-05-30 | 2006-06-15 | 뉴로서치 에이/에스 | 8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법 |
| AR013184A1 (es) * | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
| US5952339A (en) | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
| DK1068208T3 (da) | 1998-04-02 | 2003-09-01 | Targacept Inc | Azatricyclo[3.3.1.1]dekanderivater og farmaceutiske sammensætninger, der indeholder dem |
| ATE255888T1 (de) | 1998-06-01 | 2003-12-15 | Ortho Mcneil Pharm Inc | Tetrahydronaphtalene verbindungen und deren verwendung zur behandlung von neurodegenerativen krankheiten |
| US6310043B1 (en) | 1998-08-07 | 2001-10-30 | Governors Of The University Of Alberta | Treatment of bacterial infections |
| GB9821503D0 (en) | 1998-10-02 | 1998-11-25 | Novartis Ag | Organic compounds |
| US6432975B1 (en) | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| US6734215B2 (en) | 1998-12-16 | 2004-05-11 | University Of South Florida | Exo-S-mecamylamine formulation and use in treatment |
| SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
| FR2791678B1 (fr) | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
| SE9904176D0 (sv) * | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
| SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| GB0010955D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
| BR0112297A (pt) | 2000-06-27 | 2003-05-06 | S A L V A T Lab Sa | Compostos carbamatos derivados de arilalquilaminas |
| AU2001282873A1 (en) * | 2000-08-18 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
| WO2002016356A2 (en) | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
| WO2002016358A2 (en) | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
| WO2002017358A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists) |
| JP2004506734A (ja) | 2000-08-21 | 2004-03-04 | ファルマシア・アンド・アップジョン・カンパニー | 疾患治療用のキヌクリド置換ヘテロアリール部分 |
| US6599916B2 (en) | 2000-08-21 | 2003-07-29 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| EP1345937B1 (en) | 2000-12-22 | 2005-09-28 | Almirall Prodesfarma AG | Quinuclidine carbamate derivatives and their use as m3 antagonists |
| US20020086871A1 (en) * | 2000-12-29 | 2002-07-04 | O'neill Brian Thomas | Pharmaceutical composition for the treatment of CNS and other disorders |
| SI1397366T1 (sl) | 2001-06-01 | 2007-06-30 | Astrazeneca Ab | Nov ligand za nikotinske acetilholinske receptorje, koristen v terapiji |
| US6569865B2 (en) * | 2001-06-01 | 2003-05-27 | Astrazeneca Ab | Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine |
| AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| WO2003011837A1 (en) | 2001-08-01 | 2003-02-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6562816B2 (en) | 2001-08-24 | 2003-05-13 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease |
| BR0212123A (pt) | 2001-08-24 | 2004-07-20 | Upjohn Co | 7-aza[2.2.1]biciclo-heptanos substituìdos com arila para o tratamento de doenças |
| EP1425286B1 (en) | 2001-09-12 | 2007-02-28 | Pharmacia & Upjohn Company LLC | Substituted 7-aza-[2.2.1]bicycloheptanes for the treatment of diseases |
| CA2476681A1 (en) | 2002-02-19 | 2003-08-28 | Bruce N. Rogers | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
| MXPA04007083A (es) | 2002-02-20 | 2004-10-29 | Upjohn Co | Compuestos azabiciclicos para el tratamiento de enfermedades. |
| DE60333746D1 (de) * | 2002-04-18 | 2010-09-23 | Astrazeneca Ab | Thienylverbindungen |
| US7417049B2 (en) | 2002-04-18 | 2008-08-26 | Astrazeneca Ab | Furyl compounds |
| EP1499616B1 (en) | 2002-04-18 | 2009-06-17 | AstraZeneca AB | Heterocyclic compounds |
| US7176198B2 (en) * | 2002-08-01 | 2007-02-13 | Pfizer Inc. | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease |
| SE0202465D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| ATE384720T1 (de) | 2002-08-14 | 2008-02-15 | Neurosearch As | Chinucledin - derivate und deren verwendung |
| SE0202430D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| JP2006501246A (ja) | 2002-08-30 | 2006-01-12 | メモリー・ファーマシューティカルズ・コーポレイション | 神経変性疾患の治療において有用なアナバセイン誘導体 |
| AU2003276919B2 (en) | 2002-09-25 | 2013-05-16 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| BR0315056A (pt) | 2002-11-01 | 2005-08-16 | Pharmacia & Upjohn Co Llc | Compostos tendo tanto atividade agonista nicotìnica de alfa7 quanto atividade antagonista de 5ht3 para o tratamento de doenças do sistema nervoso central |
| WO2004039366A1 (en) | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
| CN1735414A (zh) | 2002-12-06 | 2006-02-15 | 北岸长岛犹太人研究学院 | 用α7受体结合类胆碱激动剂抑制炎症 |
| HRP20050522A2 (en) | 2002-12-11 | 2005-12-31 | Pharmacia & Upjohn Company Llc | Combination for the treatment of adhd |
| MXPA05005666A (es) | 2002-12-11 | 2005-07-26 | Pharmacia & Upjohn Co Llc | Tratamiento de enfermedades con combinaciones de agonistas del receptor nicotinico de acetilcolina alfa-7 y otros compuestos. |
| US6917746B2 (en) | 2002-12-17 | 2005-07-12 | 3M Innovative Properties Company | Apparatus and method for creating a fiber optic circuit |
| US6777617B2 (en) | 2002-12-30 | 2004-08-17 | 3M Innovative Properties Company | Telecommunications terminal |
| MXPA05006861A (es) | 2003-02-27 | 2005-12-12 | Neurosearch As | Derivados arildiazabiciclicos novedosos. |
| CN1829721A (zh) | 2003-07-08 | 2006-09-06 | 阿斯利康(瑞典)有限公司 | 对α7烟碱乙酰胆碱受体具有亲和力的螺[1-氮杂二环[2.2.2]辛烷-3,5’-噁唑烷]-2’-酮衍生物 |
| MXPA06003196A (es) | 2003-09-25 | 2006-06-23 | Astrazeneca Ab | Ligandos. |
| CN100494202C (zh) | 2003-10-21 | 2009-06-03 | 阿斯利康(瑞典)有限公司 | 螺呋喃并吡啶芳基衍生物 |
| US7160876B2 (en) | 2003-12-22 | 2007-01-09 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US20050137217A1 (en) | 2003-12-22 | 2005-06-23 | Jianguo Ji | Spirocyclic quinuclidinic ether derivatives |
| US20050137203A1 (en) | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-quinuclidinyl amino-substituted biaryl derivatives |
| US20050245531A1 (en) | 2003-12-22 | 2005-11-03 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US20050137398A1 (en) | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-Quinuclidinyl heteroatom bridged biaryl derivatives |
| JP2007520527A (ja) * | 2004-02-04 | 2007-07-26 | ノイロサーチ アクティーゼルスカブ | ニコチン性アセチルコリン受容体リガンドとしてのジアザ2環式アリール誘導体 |
| JP2007534692A (ja) | 2004-04-22 | 2007-11-29 | メモリー・ファーマシューティカルズ・コーポレイション | インドール、1h−インダゾール、1,2−ベンズイソキサゾール、1,2−ベンゾイソチアゾール、ならびにその調製および使用 |
| US7632831B2 (en) | 2004-05-07 | 2009-12-15 | Memory Pharmaceuticals Corporation | 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
| CN101035792B (zh) * | 2004-10-20 | 2010-09-15 | 神经研究公司 | 新颖的二氮杂双环芳基衍生物和它们的医药用途 |
| WO2006065209A1 (en) | 2004-12-15 | 2006-06-22 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| RU2418797C2 (ru) * | 2004-12-22 | 2011-05-20 | Мемори Фармасьютиклз Корпорейшн | Лиганды никотинового рецептора альфа-7, их получение и применение |
| EP1891036A4 (en) | 2005-06-07 | 2010-08-04 | Univ Florida | SELECTIVE LIGANDS FOR ALPHA-7 NICOTINE RECEPTORS |
| DE602006017235D1 (de) * | 2005-08-22 | 2010-11-11 | Targacept Inc | Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung |
| CA2622677A1 (en) | 2005-09-23 | 2007-04-05 | Richard Schumacher | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| US8316104B2 (en) * | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| SA08290475B1 (ar) * | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| RU2481123C2 (ru) * | 2008-02-13 | 2013-05-10 | Таргасепт, Инк. | Комбинация агонистов альфа 7 никотиновых рецепторов и антипсихотических средств |
-
2008
- 2008-07-03 SA SA08290475A patent/SA08290475B1/ar unknown
- 2008-07-31 TW TW102135271A patent/TW201402116A/zh unknown
- 2008-07-31 TW TW102135272A patent/TW201402117A/zh unknown
- 2008-07-31 TW TW097129030A patent/TWI429435B/zh not_active IP Right Cessation
- 2008-08-01 NZ NZ582986A patent/NZ582986A/en not_active IP Right Cessation
- 2008-08-01 SA SA112330303A patent/SA112330303B1/ar unknown
- 2008-08-01 NZ NZ582828A patent/NZ582828A/en not_active IP Right Cessation
- 2008-08-01 CN CN200880101593A patent/CN101868237A/zh active Pending
- 2008-08-01 BR BRPI0815009-5A2A patent/BRPI0815009A2/pt not_active IP Right Cessation
- 2008-08-01 WO PCT/US2008/071893 patent/WO2009018511A2/en not_active Ceased
- 2008-08-01 EP EP11194161.3A patent/EP2465501B1/en active Active
- 2008-08-01 DK DK08782584.0T patent/DK2182949T3/da active
- 2008-08-01 AU AU2008283813A patent/AU2008283813A1/en not_active Abandoned
- 2008-08-01 PH PH1/2012/501513A patent/PH12012501513A1/en unknown
- 2008-08-01 DK DK11194142.3T patent/DK2431037T3/en active
- 2008-08-01 PE PE2012000921A patent/PE20121821A1/es not_active Application Discontinuation
- 2008-08-01 PT PT87825840T patent/PT2182949E/pt unknown
- 2008-08-01 AR ARP080103348A patent/AR067775A1/es not_active Application Discontinuation
- 2008-08-01 EP EP12164661A patent/EP2484363A1/en not_active Withdrawn
- 2008-08-01 MX MX2010001293A patent/MX2010001293A/es not_active Application Discontinuation
- 2008-08-01 KR KR1020107004202A patent/KR20100063043A/ko not_active Withdrawn
- 2008-08-01 JP JP2010520219A patent/JP2010535252A/ja active Pending
- 2008-08-01 ES ES11194161.3T patent/ES2606752T3/es active Active
- 2008-08-01 EP EP11194142.3A patent/EP2431037B1/en active Active
- 2008-08-01 KR KR1020107004216A patent/KR20100051684A/ko not_active Ceased
- 2008-08-01 CN CN200880103971.1A patent/CN101784273B/zh not_active Expired - Fee Related
- 2008-08-01 EP EP08782584A patent/EP2182949B1/en active Active
- 2008-08-01 CA CA2694510A patent/CA2694510A1/en not_active Abandoned
- 2008-08-01 PE PE2008001292A patent/PE20090566A1/es not_active Application Discontinuation
- 2008-08-01 MY MYPI2010000501A patent/MY148002A/en unknown
- 2008-08-01 WO PCT/US2008/071872 patent/WO2009018505A1/en not_active Ceased
- 2008-08-01 PL PL08782584T patent/PL2182949T3/pl unknown
- 2008-08-01 BR BRPI0814889A patent/BRPI0814889A2/pt not_active IP Right Cessation
- 2008-08-01 CA CA2694504A patent/CA2694504C/en not_active Expired - Fee Related
- 2008-08-01 CL CL2008002271A patent/CL2008002271A1/es unknown
- 2008-08-01 CN CN201611140124.5A patent/CN106831755A/zh active Pending
- 2008-08-01 ES ES11194142.3T patent/ES2611139T3/es active Active
- 2008-08-01 MX MX2012009258A patent/MX346748B/es unknown
- 2008-08-01 MX MX2012009257A patent/MX346451B/es unknown
- 2008-08-01 AU AU2008283807A patent/AU2008283807B2/en not_active Ceased
- 2008-08-01 US US12/184,312 patent/US7981906B2/en active Active
- 2008-08-01 EP EP11075209A patent/EP2409703A1/en not_active Withdrawn
- 2008-08-01 JP JP2010520213A patent/JP5358573B2/ja active Active
- 2008-08-01 ES ES08782584T patent/ES2415107T3/es active Active
- 2008-08-01 ME MEP-2013-28A patent/ME01508B/me unknown
- 2008-08-01 EP EP08782589A patent/EP2185152A2/en not_active Withdrawn
- 2008-08-01 PH PH1/2012/501514A patent/PH12012501514A1/en unknown
- 2008-08-01 SI SI200830931T patent/SI2182949T1/sl unknown
- 2008-08-01 CN CN2013100489009A patent/CN103172628A/zh active Pending
- 2008-08-01 HU HUE11194142A patent/HUE030387T2/en unknown
- 2008-08-01 RS RS20130115A patent/RS52743B/sr unknown
- 2008-08-01 US US12/674,327 patent/US20110124678A1/en not_active Abandoned
- 2008-08-01 PE PE2012000920A patent/PE20121820A1/es not_active Application Discontinuation
- 2008-08-01 HR HRP20130286AT patent/HRP20130286T1/hr unknown
- 2008-08-01 UY UY0001031265A patent/UY31265A/es not_active Application Discontinuation
-
2010
- 2010-01-18 NO NO20100078A patent/NO20100078L/no not_active Application Discontinuation
- 2010-01-18 NO NO20100077A patent/NO20100077L/no not_active Application Discontinuation
- 2010-01-29 ZA ZA2010/00719A patent/ZA201000719B/en unknown
- 2010-03-02 CO CO10024587A patent/CO6260081A2/es not_active Application Discontinuation
- 2010-03-02 CO CO10024579A patent/CO6260080A2/es not_active Application Discontinuation
- 2010-03-02 EC EC2010010007A patent/ECSP10010007A/es unknown
- 2010-03-02 EC EC2010010008A patent/ECSP10010008A/es unknown
-
2011
- 2011-05-26 US US13/116,163 patent/US8119659B2/en active Active
- 2011-05-26 US US13/116,080 patent/US8541446B2/en active Active
-
2012
- 2012-04-02 IL IL218976A patent/IL218976A0/en not_active IP Right Cessation
- 2012-06-04 AU AU2012203288A patent/AU2012203288B2/en not_active Ceased
- 2012-09-19 RU RU2012140182/15A patent/RU2012140182A/ru not_active Application Discontinuation
- 2012-09-19 RU RU2012140148/15A patent/RU2012140148A/ru not_active Application Discontinuation
-
2013
- 2013-01-30 CY CY20131100081T patent/CY1113561T1/el unknown
- 2013-07-17 JP JP2013148087A patent/JP5852611B2/ja active Active
- 2013-07-17 JP JP2013148091A patent/JP6106549B2/ja active Active
- 2013-07-22 US US13/947,157 patent/US8846715B2/en active Active
- 2013-08-02 CL CL2013002227A patent/CL2013002227A1/es unknown
- 2013-08-02 CL CL2013002226A patent/CL2013002226A1/es unknown
-
2014
- 2014-08-25 US US14/467,289 patent/US20150045386A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010535252A5 (enExample) | ||
| CN101534809B (zh) | 取代的2-氨基1,2,3,4-四氢化萘在制备预防、减轻和/或治疗各类疼痛的药物中的用途 | |
| JP2008007519A5 (enExample) | ||
| FI3287124T3 (fi) | Ketamiinin oraalinen annosmuoto | |
| JP2007504174A5 (enExample) | ||
| JP2009542702A5 (enExample) | ||
| MX2010005342A (es) | Compuestos indola y metodos para tratar el dolor visceral. | |
| JP2009542699A5 (enExample) | ||
| JP2013525444A5 (enExample) | ||
| NZ593754A (en) | Dpp-iv inhibitors for treatment of diabetes in paediatric patients | |
| JP2011516417A5 (enExample) | ||
| WO2011014255A8 (en) | Treatment of crohn's disease with laquinimod | |
| JP2016185995A5 (enExample) | ||
| CN1440283A (zh) | 有机化合物的联合形式 | |
| RU2010143864A (ru) | Способы лечения нарушений с применением селективного антагониста nr2b-подтипа nmda рецепторов | |
| EP2283843A3 (en) | Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) | |
| NZ613291A (en) | Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof | |
| JP2008535785A5 (enExample) | ||
| WO2007105113A3 (en) | Use of crf1 receptor antagonists for preparing a drug for treating metabolic syndrome and/or obesity and/or dyslipoproteinemia | |
| PH12014502448A1 (en) | Pharmaceutical combinations for the treatment of metabolic disorders | |
| US20140045801A1 (en) | Pramipexole transdermal delivery for severe headaches | |
| JP2012531402A5 (enExample) | ||
| WO2007145863A3 (en) | Sustained release formulation of naltrexone | |
| RS51388B2 (sr) | Primena jedne kombinacije morfina i najmanje jednog opijat antagonista za tretman zavisnosti od opijata i za smanjenje neoralne zloupotrebe kod zavisnika od opijata | |
| JP2008538582A (ja) | 精神病性障害の治療または予防のための新規の治療的組み合わせ |