CO6260080A2 - (2s,3r)-n-(2-((3-piridinil)metil)-azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida, formas de sal novedosas y metodos de uso de los mismos - Google Patents

(2s,3r)-n-(2-((3-piridinil)metil)-azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida, formas de sal novedosas y metodos de uso de los mismos

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Publication number
CO6260080A2
CO6260080A2 CO10024579A CO10024579A CO6260080A2 CO 6260080 A2 CO6260080 A2 CO 6260080A2 CO 10024579 A CO10024579 A CO 10024579A CO 10024579 A CO10024579 A CO 10024579A CO 6260080 A2 CO6260080 A2 CO 6260080A2
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CO
Colombia
Prior art keywords
acid
benzofuran
carboxamide
oct
methyl
Prior art date
Application number
CO10024579A
Other languages
English (en)
Inventor
Merouane Bencharif
Lisa Benson
Gary Dull
Nikolai Fedorov
Gregory Gatto
John Genus
Kristen Jordan
Jacob Mathew
Anatoly Mazurov
Lan Miao
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39945177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6260080(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of CO6260080A2 publication Critical patent/CO6260080A2/es

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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

1.- (2S,3R)N-(2-((3-piridinil)metil-1- -azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida o una sal farmacéuticamente aceptable del mismo. 2.- (2S.3R)N-(2-((3-piridinil)metil-1-azabiciclo[2.2,2)oct-3-il)benzofuran-2-carboxamida, en forma sustancialmente pura, o una sal farmacéuticamente aceptable del mismo. 3.- (2S,3R)N-(2-((3-piridinil]metil-1-azabiciclo[2.2.2)oct-3-il)benzofuran-2-carboxamida, sustancialmente libre de isómeros (2S.3S), (2R.3S), o (2R,3R), o una sal farmacéuticamente aceptable de los mismos. 4.- (2S,3R)-N-(2-((3-piridinil)metil-1- azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida estereoisoméricamente enriquecido, o una sal farmacéuticamente aceptable del mismo. 5.- El (2S,3R)- N-(2-((3-piridinil)metil-1-azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida estereoisoméricamente enriquecido de la reivindicación 4, en donde el exceso enantiomérico o diastereomérico se selecciona de 90% o más; 95% o más; 98% o más; 99% o más; o 99.5% o más. 6.- Una sal de ácido de (2S.3R) N-(2-((3-piridinil)metil-1-azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida, en donde el ácido se selecciona de ácido clorhídrico, ácido sulfúrico, ácido fosfórico, ácido maleico, ácido toluenosulfónico, ácido galactárico (múcico), ácido D-mandélico, ácido D-tartárico, ácido metanosulfónico, ácidos R- y S-10-camforsulfónico, ácido ketoglurárico, o ácido hipúrico.
CO10024579A 2007-08-02 2010-03-02 (2s,3r)-n-(2-((3-piridinil)metil)-azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida, formas de sal novedosas y metodos de uso de los mismos CO6260080A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95361007P 2007-08-02 2007-08-02
US95361307P 2007-08-02 2007-08-02
US95361407P 2007-08-02 2007-08-02
US97165407P 2007-09-12 2007-09-12

Publications (1)

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CO6260080A2 true CO6260080A2 (es) 2011-03-22

Family

ID=39945177

Family Applications (2)

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CO10024579A CO6260080A2 (es) 2007-08-02 2010-03-02 (2s,3r)-n-(2-((3-piridinil)metil)-azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida, formas de sal novedosas y metodos de uso de los mismos
CO10024587A CO6260081A2 (es) 2007-08-02 2010-03-02 Un medicamento para tratar o prevenir trastornos metabolicos que contiene un agonista nachr (alfa)7 selectivo

Family Applications After (1)

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CO10024587A CO6260081A2 (es) 2007-08-02 2010-03-02 Un medicamento para tratar o prevenir trastornos metabolicos que contiene un agonista nachr (alfa)7 selectivo

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US (6) US7981906B2 (es)
EP (6) EP2182949B1 (es)
JP (4) JP2010535252A (es)
KR (2) KR20100063043A (es)
CN (4) CN106831755A (es)
AR (1) AR067775A1 (es)
AU (3) AU2008283813A1 (es)
BR (2) BRPI0814889A2 (es)
CA (2) CA2694504C (es)
CL (3) CL2008002271A1 (es)
CO (2) CO6260080A2 (es)
CY (1) CY1113561T1 (es)
DK (2) DK2182949T3 (es)
EC (2) ECSP10010007A (es)
ES (3) ES2611139T3 (es)
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HR (1) HRP20130286T1 (es)
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NO (2) NO20100078L (es)
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PE (3) PE20090566A1 (es)
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PT (1) PT2182949E (es)
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RU (2) RU2012140182A (es)
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