CL2007003822A1 - Compuestos derivados de isoquinolina e isoquinolinona, inhibidores de rho-quinasa; composicion farmaceutica; y uso para tratar y/o prevenir hipertension, retinopatia, glaucoma, fibrosis pulmonar, alzheimer, disfuncion erectil, trastornos tromboticos, entre otras. - Google Patents

Compuestos derivados de isoquinolina e isoquinolinona, inhibidores de rho-quinasa; composicion farmaceutica; y uso para tratar y/o prevenir hipertension, retinopatia, glaucoma, fibrosis pulmonar, alzheimer, disfuncion erectil, trastornos tromboticos, entre otras.

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Publication number
CL2007003822A1
CL2007003822A1 CL2007003822A CL2007003822A CL2007003822A1 CL 2007003822 A1 CL2007003822 A1 CL 2007003822A1 CL 2007003822 A CL2007003822 A CL 2007003822A CL 2007003822 A CL2007003822 A CL 2007003822A CL 2007003822 A1 CL2007003822 A1 CL 2007003822A1
Authority
CL
Chile
Prior art keywords
glaucoma
retinopathy
alzheimer
treat
pharmaceutical composition
Prior art date
Application number
CL2007003822A
Other languages
English (en)
Inventor
Joachim Brendel
Armin Hofmeister
Oliver Plettenburg
Matthias Löhn
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38191090&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007003822(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CL2007003822A1 publication Critical patent/CL2007003822A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)

Abstract

COMPUESTO DE FÓRMULA (I), DONDE R1-R8, N, M Y L SON COMO SE DEFINE EN LAS REIVINDICACIONES, O SUS FORMAS ESTEREOISOMÉRICAS Y/O TAUTOMÉRICAS Y/O SUS SALES FARMACÉUTICAMENTE ACEPTABLES.<br /> USO DE DICHO COMPUESTO Y/O SUS SALES FARMACÉUTICAMENTE ACEPTABLES PARA TRATAR Y/O PREVENIR HIPERTENSIÓN, RETINOPATÍA, GLAUCOMA, FIBROSIS PULMONAR, ALZHEIMER, DISFUNCIÓN ERÉCTIL, TRASTORNOS TROMBÓTICOS, ENTRE OTRAS. COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE UNA CANTIDAD DE DICHO COMPUESTO Y/O UNA SAL<br /> FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, EXCIPIENTES Y VEHÍCULOS TOLERADOS FISIOLÓGICAMENTE Y, CUANDO SEA APROPIADO, ADITIVOS.<br />  
CL2007003822A 2006-12-27 2007-12-26 Compuestos derivados de isoquinolina e isoquinolinona, inhibidores de rho-quinasa; composicion farmaceutica; y uso para tratar y/o prevenir hipertension, retinopatia, glaucoma, fibrosis pulmonar, alzheimer, disfuncion erectil, trastornos tromboticos, entre otras. CL2007003822A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06026898 2006-12-27

Publications (1)

Publication Number Publication Date
CL2007003822A1 true CL2007003822A1 (es) 2009-10-16

Family

ID=38191090

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2007003822A CL2007003822A1 (es) 2006-12-27 2007-12-26 Compuestos derivados de isoquinolina e isoquinolinona, inhibidores de rho-quinasa; composicion farmaceutica; y uso para tratar y/o prevenir hipertension, retinopatia, glaucoma, fibrosis pulmonar, alzheimer, disfuncion erectil, trastornos tromboticos, entre otras.

Country Status (28)

Country Link
US (2) US8278294B2 (es)
EP (1) EP2102187B1 (es)
JP (1) JP5421783B2 (es)
KR (1) KR101517154B1 (es)
CN (1) CN101616909B (es)
AR (1) AR064533A1 (es)
AU (1) AU2007338406B2 (es)
BR (1) BRPI0720862A2 (es)
CA (1) CA2673916C (es)
CL (1) CL2007003822A1 (es)
CO (1) CO6321138A2 (es)
CR (1) CR10812A (es)
DO (1) DOP2009000163A (es)
EC (1) ECSP099466A (es)
HK (1) HK1140201A1 (es)
IL (1) IL199541A (es)
MA (1) MA31021B1 (es)
MX (1) MX2009005825A (es)
MY (1) MY150746A (es)
NI (1) NI200900107A (es)
NO (1) NO20092421L (es)
NZ (1) NZ577981A (es)
RU (1) RU2455302C2 (es)
TN (1) TN2009000270A1 (es)
TW (1) TWI435723B (es)
UY (1) UY30840A1 (es)
WO (1) WO2008077550A1 (es)
ZA (1) ZA200903550B (es)

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