HN2008000130A - Derivados de isoquinolona sustituidos con piperidinilo en calida de inhibidores de rho-quinasa - Google Patents
Derivados de isoquinolona sustituidos con piperidinilo en calida de inhibidores de rho-quinasaInfo
- Publication number
- HN2008000130A HN2008000130A HN2008000130A HN2008000130A HN2008000130A HN 2008000130 A HN2008000130 A HN 2008000130A HN 2008000130 A HN2008000130 A HN 2008000130A HN 2008000130 A HN2008000130 A HN 2008000130A HN 2008000130 A HN2008000130 A HN 2008000130A
- Authority
- HN
- Honduras
- Prior art keywords
- rho
- piperidinyl
- quality
- isoquinolone derivatives
- derivatives replaced
- Prior art date
Links
- -1 PIPERIDINYL Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical class C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 title 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000000568 rho-Associated Kinases Human genes 0.000 abstract 1
- 108010041788 rho-Associated Kinases Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Virology (AREA)
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Abstract
LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE ISOQUINOLONA I ISOQUINOLINA, A SU PREPARACION Y A SU USO EN EL TRATAMIENTO Y/O PREVENCION DE ENFERMEDADES RELACIONADAS CON LA INHIBICION DE LA RHO- QUINASA Y/O DE LA FOSFORILACION MEDIADA POR LA RHO-QUINASA DE LA FOSFATASA DE LA CADENA LIGERA DE MIOSINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05016153 | 2005-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HN2008000130A true HN2008000130A (es) | 2010-12-27 |
Family
ID=35115842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HN2008000130A HN2008000130A (es) | 2005-07-26 | 2008-01-28 | Derivados de isoquinolona sustituidos con piperidinilo en calida de inhibidores de rho-quinasa |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US8609691B2 (es) |
| EP (1) | EP1912949B1 (es) |
| JP (1) | JP5049970B2 (es) |
| KR (1) | KR101336678B1 (es) |
| CN (1) | CN101228132B (es) |
| AR (1) | AR057082A1 (es) |
| AT (1) | ATE521595T1 (es) |
| AU (1) | AU2006274246B2 (es) |
| BR (1) | BRPI0614063A2 (es) |
| CA (1) | CA2615663C (es) |
| CR (1) | CR9604A (es) |
| CY (1) | CY1112085T1 (es) |
| DK (1) | DK1912949T3 (es) |
| DO (1) | DOP2006000177A (es) |
| EC (1) | ECSP088136A (es) |
| ES (1) | ES2372067T3 (es) |
| GT (1) | GT200600327A (es) |
| HK (1) | HK1123036A1 (es) |
| HN (1) | HN2008000130A (es) |
| HR (1) | HRP20110839T1 (es) |
| IL (1) | IL188949A (es) |
| MA (1) | MA29639B1 (es) |
| MX (1) | MX2008000956A (es) |
| MY (1) | MY146644A (es) |
| NI (1) | NI200800024A (es) |
| NO (1) | NO20080965L (es) |
| NZ (1) | NZ565669A (es) |
| PE (1) | PE20070181A1 (es) |
| PL (1) | PL1912949T3 (es) |
| PT (1) | PT1912949E (es) |
| RS (1) | RS52241B (es) |
| RU (1) | RU2440988C2 (es) |
| SI (1) | SI1912949T1 (es) |
| TN (1) | TNSN08038A1 (es) |
| TW (1) | TWI412521B (es) |
| WO (1) | WO2007012422A1 (es) |
| ZA (1) | ZA200710952B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1899322E (pt) | 2005-06-28 | 2009-11-09 | Sanofi Aventis | Derivados de isoquinolina como inibidores de rho-cinase |
| BRPI0613861B8 (pt) | 2005-07-26 | 2021-05-25 | Sanofi Aventis | derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase |
| RS52241B (en) | 2005-07-26 | 2012-10-31 | Sanofi | CYCLOHEXYLAMINE ISOHINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS |
| US7893088B2 (en) | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| US7906504B2 (en) * | 2006-09-11 | 2011-03-15 | N.V. Organon | 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivatives |
| JP5405316B2 (ja) * | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノリン誘導体 |
| CN101616909B (zh) | 2006-12-27 | 2013-09-11 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 |
| WO2008077555A2 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinolines and their use as rho-kinase inhibitors |
| MX2009006517A (es) | 2006-12-27 | 2009-06-26 | Sanofi Aventis | Nuevos derivados de isoquinolina e isoquinolinona sustituidos. |
| ATE490243T1 (de) | 2006-12-27 | 2010-12-15 | Sanofi Aventis | Cycloalkylaminsubstituierte isochinolin- und isochinolinonderivate |
| ES2625266T3 (es) * | 2006-12-27 | 2017-07-19 | Sanofi | Derivados de isoquinolona sustituidos con cicloalquilamina |
| TW200845988A (en) | 2007-04-05 | 2008-12-01 | Astrazeneca Ab | New compounds and their uses 707 |
| AU2008317353B2 (en) * | 2007-10-24 | 2014-08-07 | Merck Sharp & Dohme Llc | Heterocycle phenyl amide T-type calcium channel antagonists |
| CN102131784B (zh) * | 2008-06-24 | 2014-08-27 | 赛诺菲-安万特 | 作为rho激酶抑制剂的取代的异喹啉和异喹啉酮 |
| JP5715561B2 (ja) | 2008-06-24 | 2015-05-07 | サノフイ | 二及び多環式置換イソキノリン及びイソキノリノン誘導体 |
| MX2010013974A (es) * | 2008-06-24 | 2011-01-14 | Sanofi Aventis | Isoquinolinas e isoquinolinonas 6-sustituidas. |
| CA2733533C (en) | 2008-08-25 | 2013-12-17 | Irm Llc | Hedgehog pathway modulators |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| WO2014113620A2 (en) * | 2013-01-18 | 2014-07-24 | Bristol-Myers Squibb Company | Phthalazinones and isoquinolinones as rock inhibitors |
| ES2930305T3 (es) | 2013-10-18 | 2022-12-09 | Celgene Quanticel Res Inc | Inhibidores del bromodominio |
| WO2015060373A1 (ja) * | 2013-10-23 | 2015-04-30 | 中外製薬株式会社 | キナゾリノンおよびイソキノリノン誘導体 |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN105085478B (zh) * | 2014-04-28 | 2019-04-12 | 南京明德新药研发股份有限公司 | 异喹啉磺胺衍生物及其药物组合物和制药用途 |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| WO2016180918A1 (en) | 2015-05-12 | 2016-11-17 | Platod | Combination of pharmacological and microfluidic features for improved platelets production |
| US9957267B2 (en) | 2015-07-01 | 2018-05-01 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| AU2017252276A1 (en) | 2016-04-18 | 2018-11-15 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| CA3102645A1 (en) * | 2018-06-07 | 2019-12-12 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
| CN114874236B (zh) * | 2022-06-24 | 2023-05-05 | 中国工程物理研究院化工材料研究所 | 一种五元氮杂稠环骨架及其制备方法 |
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| FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| EP0541559A1 (en) | 1990-07-31 | 1993-05-19 | E.I. Du Pont De Nemours And Company | Catalytic equilibration of selected halocarbons |
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