MA29639B1 - Derives de cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rhokinase. - Google Patents

Derives de cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rhokinase.

Info

Publication number
MA29639B1
MA29639B1 MA30586A MA30586A MA29639B1 MA 29639 B1 MA29639 B1 MA 29639B1 MA 30586 A MA30586 A MA 30586A MA 30586 A MA30586 A MA 30586A MA 29639 B1 MA29639 B1 MA 29639B1
Authority
MA
Morocco
Prior art keywords
isoquinolone
rhokinase
inhibitors
derivatives
cyclohexylamine derivatives
Prior art date
Application number
MA30586A
Other languages
English (en)
Inventor
Olivier Plettenburg
Armin Hofmeister
Dieter Kadereit
Joachim Brendel
Matthias Loehn
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA29639B1 publication Critical patent/MA29639B1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
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  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
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Abstract

L'invention concerne des dérivés de l'isoquinolone de formule (I) ou des dérivés de l'isoquinoline de formule (I) substitués en 6-cyclohexylamine, utiles pour la prévention et/ou le traitement de maladies associées à la Rho-kinase et/ou à la phosphorylation de la phosphatase à chaîne légère de la myosine par l'intermédiaire de la Rho-kinase, et des compositions qui contiennent de tel composants.
MA30586A 2005-07-26 2008-01-21 Derives de cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rhokinase. MA29639B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05016153 2005-07-26

Publications (1)

Publication Number Publication Date
MA29639B1 true MA29639B1 (fr) 2008-07-01

Family

ID=35115842

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30586A MA29639B1 (fr) 2005-07-26 2008-01-21 Derives de cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rhokinase.

Country Status (37)

Country Link
US (2) US8609691B2 (fr)
EP (1) EP1912949B1 (fr)
JP (1) JP5049970B2 (fr)
KR (1) KR101336678B1 (fr)
CN (1) CN101228132B (fr)
AR (1) AR057082A1 (fr)
AT (1) ATE521595T1 (fr)
AU (1) AU2006274246B2 (fr)
BR (1) BRPI0614063A2 (fr)
CA (1) CA2615663C (fr)
CR (1) CR9604A (fr)
CY (1) CY1112085T1 (fr)
DK (1) DK1912949T3 (fr)
DO (1) DOP2006000177A (fr)
EC (1) ECSP088136A (fr)
ES (1) ES2372067T3 (fr)
GT (1) GT200600327A (fr)
HK (1) HK1123036A1 (fr)
HN (1) HN2008000130A (fr)
HR (1) HRP20110839T1 (fr)
IL (1) IL188949A (fr)
MA (1) MA29639B1 (fr)
MX (1) MX2008000956A (fr)
MY (1) MY146644A (fr)
NI (1) NI200800024A (fr)
NO (1) NO20080965L (fr)
NZ (1) NZ565669A (fr)
PE (1) PE20070181A1 (fr)
PL (1) PL1912949T3 (fr)
PT (1) PT1912949E (fr)
RS (1) RS52241B (fr)
RU (1) RU2440988C2 (fr)
SI (1) SI1912949T1 (fr)
TN (1) TNSN08038A1 (fr)
TW (1) TWI412521B (fr)
WO (1) WO2007012422A1 (fr)
ZA (1) ZA200710952B (fr)

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MX2008001053A (es) 2005-07-26 2008-03-19 Sanofi Aventis Derivados de isoquinolona sustituidos con piperidinilo en calidad de inhibidores de rho-quinasa.
CN101228132B (zh) 2005-07-26 2012-10-10 塞诺菲-安万特股份有限公司 作为Rho-激酶抑制剂的环己基胺异喹啉酮衍生物
US7893088B2 (en) 2006-08-18 2011-02-22 N.V. Organon 6-substituted isoquinoline derivatives
US7906504B2 (en) * 2006-09-11 2011-03-15 N.V. Organon 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivatives
BRPI0721180A2 (pt) * 2006-12-27 2014-03-18 Sanofi Aventis Derivados de isoquinolina substituídos com cicloalquilamina
SI2102164T1 (sl) 2006-12-27 2011-03-31 Sanofi Aventis Izokinolinski in izokinolinonski derivati, substituirani s cikloalkilaminom
MX2009005825A (es) 2006-12-27 2009-06-16 Sanofi Aventis Derivados de isoquinolina e isoquinolinona sustituidos en calidad de inhibidores de rho-quinasa.
MY148902A (en) 2006-12-27 2013-06-14 Sanofi Aventis Substituted isoquinolines and their use as rho-kinase inhibitors
WO2008077551A1 (fr) 2006-12-27 2008-07-03 Sanofi-Aventis Dérivés d'isoquinolone substitués par une cycloalkylamine
CN101573353B (zh) 2006-12-27 2014-08-06 塞诺菲-安万特股份有限公司 取代的异喹啉和异喹啉酮衍生物
TW200845988A (en) 2007-04-05 2008-12-01 Astrazeneca Ab New compounds and their uses 707
KR20100072266A (ko) * 2007-10-24 2010-06-30 머크 샤프 앤드 돔 코포레이션 헤테로사이클 페닐 아미드 ｔ-형 칼슘 채널 길항제
WO2009156099A1 (fr) * 2008-06-24 2009-12-30 Sanofi-Aventis Isoquinolines et isoquinolinones à substitution en 6
WO2009156100A1 (fr) * 2008-06-24 2009-12-30 Sanofi-Aventis Isoquinolines et isoquinolinones substituées utilisées comme inhibiteurs de rho-kinase
WO2009156092A2 (fr) * 2008-06-24 2009-12-30 Sanofi-Aventis Derivés bicycliques et polycycliques d’isoquinoline et d’isoquinolinone substitués
BRPI0917936A2 (pt) 2008-08-25 2017-07-11 Irm Llc Moduladores de via hedgehog
AR073711A1 (es) 2008-10-01 2010-11-24 Astrazeneca Ab Derivados de isoquinolina
TW201443023A (zh) * 2013-01-18 2014-11-16 必治妥美雅史谷比公司 作爲ｒｏｃｋ抑制劑之酞□酮及異喹啉酮
CN108558889B (zh) 2013-10-18 2021-11-05 赛尔基因昆蒂赛尔研究公司 布罗莫结构域抑制剂
EP3061749B1 (fr) 2013-10-23 2019-02-27 Chugai Seiyaku Kabushiki Kaisha Dérivé de quinazolinone et d'isoquinolinone
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
US20180104692A1 (en) 2015-05-12 2018-04-19 Platod Combination of pharmacological and microfluidic features for improved platelets production
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SI1912949T1 (sl) 2011-12-30
RU2440988C2 (ru) 2012-01-27
MY146644A (en) 2012-09-14
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