MA29639B1 - Derives de cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rhokinase. - Google Patents

Derives de cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rhokinase.

Info

Publication number
MA29639B1
MA29639B1 MA30586A MA30586A MA29639B1 MA 29639 B1 MA29639 B1 MA 29639B1 MA 30586 A MA30586 A MA 30586A MA 30586 A MA30586 A MA 30586A MA 29639 B1 MA29639 B1 MA 29639B1
Authority
MA
Morocco
Prior art keywords
isoquinolone
rhokinase
inhibitors
derivatives
cyclohexylamine derivatives
Prior art date
Application number
MA30586A
Other languages
English (en)
Inventor
Olivier Plettenburg
Armin Hofmeister
Dieter Kadereit
Joachim Brendel
Matthias Loehn
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA29639B1 publication Critical patent/MA29639B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
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Abstract

L'invention concerne des dérivés de l'isoquinolone de formule (I) ou des dérivés de l'isoquinoline de formule (I) substitués en 6-cyclohexylamine, utiles pour la prévention et/ou le traitement de maladies associées à la Rho-kinase et/ou à la phosphorylation de la phosphatase à chaîne légère de la myosine par l'intermédiaire de la Rho-kinase, et des compositions qui contiennent de tel composants.
MA30586A 2005-07-26 2008-01-21 Derives de cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rhokinase. MA29639B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05016153 2005-07-26

Publications (1)

Publication Number Publication Date
MA29639B1 true MA29639B1 (fr) 2008-07-01

Family

ID=35115842

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30586A MA29639B1 (fr) 2005-07-26 2008-01-21 Derives de cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rhokinase.

Country Status (36)

Country Link
US (2) US8609691B2 (fr)
EP (1) EP1912949B1 (fr)
JP (1) JP5049970B2 (fr)
KR (1) KR101336678B1 (fr)
CN (1) CN101228132B (fr)
AR (1) AR057082A1 (fr)
AT (1) ATE521595T1 (fr)
AU (1) AU2006274246B2 (fr)
BR (1) BRPI0614063A2 (fr)
CA (1) CA2615663C (fr)
CR (1) CR9604A (fr)
CY (1) CY1112085T1 (fr)
DK (1) DK1912949T3 (fr)
DO (1) DOP2006000177A (fr)
EC (1) ECSP088136A (fr)
ES (1) ES2372067T3 (fr)
GT (1) GT200600327A (fr)
HN (1) HN2008000130A (fr)
HR (1) HRP20110839T1 (fr)
IL (1) IL188949A (fr)
MA (1) MA29639B1 (fr)
MX (1) MX2008000956A (fr)
MY (1) MY146644A (fr)
NI (1) NI200800024A (fr)
NO (1) NO20080965L (fr)
NZ (1) NZ565669A (fr)
PE (1) PE20070181A1 (fr)
PL (1) PL1912949T3 (fr)
PT (1) PT1912949E (fr)
RS (1) RS52241B (fr)
RU (1) RU2440988C2 (fr)
SI (1) SI1912949T1 (fr)
TN (1) TNSN08038A1 (fr)
TW (1) TWI412521B (fr)
WO (1) WO2007012422A1 (fr)
ZA (1) ZA200710952B (fr)

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PT1899322E (pt) 2005-06-28 2009-11-09 Sanofi Aventis Derivados de isoquinolina como inibidores de rho-cinase
PT1910333E (pt) 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase
HRP20110839T1 (hr) 2005-07-26 2011-12-31 Sanofi Derivati cikloheksaminizokinolona kao inhibitori rho-kinaze
US7893088B2 (en) 2006-08-18 2011-02-22 N.V. Organon 6-substituted isoquinoline derivatives
WO2008033757A2 (fr) * 2006-09-11 2008-03-20 N.V. Organon Dérivés d'acétamide 2-(1-oxo-1h-isoquinolin-2-yl)
BRPI0721180A2 (pt) * 2006-12-27 2014-03-18 Sanofi Aventis Derivados de isoquinolina substituídos com cicloalquilamina
RU2468011C2 (ru) 2006-12-27 2012-11-27 Санофи-Авентис Замещенные циклоалкиламином производные изохинолина и изохинолинона
KR101545533B1 (ko) 2006-12-27 2015-08-19 사노피 치환된 이소퀴놀린 및 Ｒｈｏ-키나아제 억제제로서의 이의 용도
MY150746A (en) 2006-12-27 2014-02-28 Sanofi Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
RU2009128693A (ru) 2006-12-27 2011-02-10 Санофи-Авентис (Fr) Замещенные производные изохинолина и изохинолинона
JP5405314B2 (ja) 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノロン誘導体
CL2008000973A1 (es) 2007-04-05 2009-01-02 Astrazeneca Ab Compuestos derivados de 1-oxo-isoquinolina; procedimiento de preparación; composición farmacéutica; y su uso en el tratamiento de enfermedades pulmonares obstructvas crónicas (epoc) y asma.
WO2009054984A1 (fr) * 2007-10-24 2009-04-30 Merck & Co., Inc. Antagonistes de canaux calciques de type t à base de phényle amide hétérocyclique
RU2538588C2 (ru) 2008-06-24 2015-01-10 Санофи-Авентис ЗАМЕЩЕННЫЕ ИЗИХИНОЛИНЫ И ИЗОХИНОЛИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ
AU2009262516B8 (en) * 2008-06-24 2014-01-30 Sanofi 6-substituted isoquinolines and isoquinolinones
MX2010013867A (es) * 2008-06-24 2011-02-24 Sanofi Aventis Derivados de isoquinolina e isoquinolinona bi- y policiclicos sustituidos.
KR101354763B1 (ko) 2008-08-25 2014-01-22 아이알엠 엘엘씨 헷지호그 경로 조절제
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US9221767B2 (en) * 2013-01-18 2015-12-29 Bristol-Myers Squibb Company Substituted phthalazinones as rock inhibitors
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KR20160073413A (ko) * 2013-10-23 2016-06-24 추가이 세이야쿠 가부시키가이샤 퀴나졸리논 및 이소퀴놀리논 유도체
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
JP6883173B2 (ja) 2015-05-12 2021-06-09 ヘモストッド エスエー 改善された血小板産生のための薬理学的特徴およびマイクロ流体特徴の組み合わせ
EP3317277B1 (fr) 2015-07-01 2021-01-20 Crinetics Pharmaceuticals, Inc. Modulateurs de la somatostatine et leurs utilisations
WO2017184462A1 (fr) 2016-04-18 2017-10-26 Celgene Quanticel Research, Inc. Composés thérapeutiques
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
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CN112839647B (zh) * 2018-06-07 2025-09-23 达萨玛治疗公司 Sarm1抑制剂
CN114874236B (zh) * 2022-06-24 2023-05-05 中国工程物理研究院化工材料研究所 一种五元氮杂稠环骨架及其制备方法

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