NO20080965L - Cykloheksylaminisokinolonderivater som Rho-kinaseinhibotorer - Google Patents

Cykloheksylaminisokinolonderivater som Rho-kinaseinhibotorer

Info

Publication number
NO20080965L
NO20080965L NO20080965A NO20080965A NO20080965L NO 20080965 L NO20080965 L NO 20080965L NO 20080965 A NO20080965 A NO 20080965A NO 20080965 A NO20080965 A NO 20080965A NO 20080965 L NO20080965 L NO 20080965L
Authority
NO
Norway
Prior art keywords
cyclohexylamine
kinase inhibitors
rho kinase
isoquinolone derivatives
derivatives
Prior art date
Application number
NO20080965A
Other languages
English (en)
Inventor
Dieter Kadereit
Armin Hofmeister
Oliver Plettenburg
Joachim Brendel
Matthias Loehn
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20080965L publication Critical patent/NO20080965L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Foreliggende oppfinnelse angår 6-cykloheksylaminsubstituerte isoquinolonderivater med formel (I) eller isoquinolinderivater med formel (F) anvendelige for behandling og/eller hindring av sykdommer assosiert med Rho-kinase og/eller Rho-kinasemediert fosforylering av myosinlettkjedefosfatase, og sammensetninger som inneholder slike forbindelser.
NO20080965A 2005-07-26 2008-02-22 Cykloheksylaminisokinolonderivater som Rho-kinaseinhibotorer NO20080965L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05016153 2005-07-26
PCT/EP2006/007140 WO2007012422A1 (en) 2005-07-26 2006-07-20 Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20080965L true NO20080965L (no) 2008-02-22

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ID=35115842

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NO20080965A NO20080965L (no) 2005-07-26 2008-02-22 Cykloheksylaminisokinolonderivater som Rho-kinaseinhibotorer

Country Status (37)

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US (2) US8609691B2 (no)
EP (1) EP1912949B1 (no)
JP (1) JP5049970B2 (no)
KR (1) KR101336678B1 (no)
CN (1) CN101228132B (no)
AR (1) AR057082A1 (no)
AT (1) ATE521595T1 (no)
AU (1) AU2006274246B2 (no)
BR (1) BRPI0614063A2 (no)
CA (1) CA2615663C (no)
CR (1) CR9604A (no)
CY (1) CY1112085T1 (no)
DK (1) DK1912949T3 (no)
DO (1) DOP2006000177A (no)
EC (1) ECSP088136A (no)
ES (1) ES2372067T3 (no)
GT (1) GT200600327A (no)
HK (1) HK1123036A1 (no)
HN (1) HN2008000130A (no)
HR (1) HRP20110839T1 (no)
IL (1) IL188949A (no)
MA (1) MA29639B1 (no)
MX (1) MX2008000956A (no)
MY (1) MY146644A (no)
NI (1) NI200800024A (no)
NO (1) NO20080965L (no)
NZ (1) NZ565669A (no)
PE (1) PE20070181A1 (no)
PL (1) PL1912949T3 (no)
PT (1) PT1912949E (no)
RS (1) RS52241B (no)
RU (1) RU2440988C2 (no)
SI (1) SI1912949T1 (no)
TN (1) TNSN08038A1 (no)
TW (1) TWI412521B (no)
WO (1) WO2007012422A1 (no)
ZA (1) ZA200710952B (no)

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CA2615663C (en) 2005-07-26 2013-10-15 Sanofi-Aventis Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors
CA2615577C (en) 2005-07-26 2014-09-09 Sanofi-Aventis Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors
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KR101494452B1 (ko) 2006-12-27 2015-02-16 사노피 사이클로알킬아민 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
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NZ577981A (en) 2006-12-27 2011-12-22 Sanofi Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
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KR101692211B1 (ko) * 2008-06-24 2017-01-03 사노피 Ｒｈｏ 키나제 억제제로서의 비사이클릭 및 폴리사이클릭 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
CA2728137C (en) * 2008-06-24 2016-10-18 Sanofi-Aventis Substituted isoquinolines and isoquinolinones as rho kinase inhibitors
CN102203067B (zh) 2008-08-25 2014-01-15 Irm责任有限公司 Hedgehog通路调节剂
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CA2898440A1 (en) * 2013-01-18 2014-07-24 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as rock inhibitors
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FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
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