MA31076B1 - Dérivés de l'isoquinoléine et de l'isoquinoléinone substitués par une cycloalkylamine. - Google Patents
Dérivés de l'isoquinoléine et de l'isoquinoléinone substitués par une cycloalkylamine.Info
- Publication number
- MA31076B1 MA31076B1 MA32040A MA32040A MA31076B1 MA 31076 B1 MA31076 B1 MA 31076B1 MA 32040 A MA32040 A MA 32040A MA 32040 A MA32040 A MA 32040A MA 31076 B1 MA31076 B1 MA 31076B1
- Authority
- MA
- Morocco
- Prior art keywords
- isocinoline
- substituted
- cycloquine
- derivatives
- rho
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Pregnancy & Childbirth (AREA)
Abstract
L'invention concerne des dérivés d'isoquinoline et d'isoquinolinone 6-substitués représentés par la formule (i), utilisés dans le traitement et/ou la prévention de maladies associées à la rho-kinase et/ou à la phosphorylation médiée par la rho-kinase de la phosphatase de la chaîne légère de la myosine, et des compositions contenant lesdits composés.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06026897 | 2006-12-27 | ||
PCT/EP2007/011169 WO2008077556A1 (fr) | 2006-12-27 | 2007-12-19 | Dérivés d'isoquinoline et d'isoquinolinone substitués par une cycloalkylamine |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31076B1 true MA31076B1 (fr) | 2010-01-04 |
Family
ID=38050127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32040A MA31076B1 (fr) | 2006-12-27 | 2009-06-24 | Dérivés de l'isoquinoléine et de l'isoquinoléinone substitués par une cycloalkylamine. |
Country Status (38)
Country | Link |
---|---|
US (1) | US8710077B2 (fr) |
EP (1) | EP2102164B1 (fr) |
JP (1) | JP5318779B2 (fr) |
KR (1) | KR101494452B1 (fr) |
CN (1) | CN101578266B (fr) |
AR (1) | AR064531A1 (fr) |
AT (1) | ATE490243T1 (fr) |
AU (1) | AU2007338412B2 (fr) |
BR (1) | BRPI0720859A2 (fr) |
CA (1) | CA2673922C (fr) |
CL (1) | CL2007003820A1 (fr) |
CO (1) | CO6210815A2 (fr) |
CR (1) | CR10811A (fr) |
CY (1) | CY1111323T1 (fr) |
DE (1) | DE602007010981D1 (fr) |
DK (1) | DK2102164T3 (fr) |
EC (1) | ECSP099468A (fr) |
ES (1) | ES2355534T3 (fr) |
GT (1) | GT200900183A (fr) |
HK (1) | HK1138585A1 (fr) |
HR (1) | HRP20100705T1 (fr) |
MA (1) | MA31076B1 (fr) |
MX (1) | MX2009005967A (fr) |
MY (1) | MY154767A (fr) |
NI (1) | NI200900111A (fr) |
NO (1) | NO20092488L (fr) |
NZ (1) | NZ577984A (fr) |
PL (1) | PL2102164T3 (fr) |
PT (1) | PT2102164E (fr) |
RS (1) | RS51655B (fr) |
RU (1) | RU2468011C2 (fr) |
SI (1) | SI2102164T1 (fr) |
SV (1) | SV2009003314A (fr) |
TN (1) | TN2009000274A1 (fr) |
TW (1) | TWI423803B (fr) |
UY (1) | UY30845A1 (fr) |
WO (1) | WO2008077556A1 (fr) |
ZA (1) | ZA200903555B (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ565040A (en) | 2005-06-28 | 2010-05-28 | Sanofi Aventis | Isoquinoline derivatives as inhibitors of RHO-kinase |
WO2007008926A1 (fr) | 2005-07-11 | 2007-01-18 | Aerie Pharmaceuticals, Inc. | Composes isoquinoliniques |
CA2615577C (fr) | 2005-07-26 | 2014-09-09 | Sanofi-Aventis | Derives de l'isoquinolone substitutee en piperidinyl en tant qu'inhibiteurs de la rho-kinase |
CA2615663C (fr) | 2005-07-26 | 2013-10-15 | Sanofi-Aventis | Derives de la cyclohexylamine isoquinolone en tant qu'inhibiteurs de la rho-kinase |
WO2008036540A2 (fr) | 2006-09-20 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Inhibiteurs de la rho-kinase |
RU2457203C2 (ru) | 2006-12-27 | 2012-07-27 | Санофи-Авентис | Замещенные циклоалкиламином производные изохинолона |
WO2008077554A1 (fr) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Dérivés d'isoquinoline substitués par une cycloalkylamine |
KR101494452B1 (ko) | 2006-12-27 | 2015-02-16 | 사노피 | 사이클로알킬아민 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
NZ577981A (en) | 2006-12-27 | 2011-12-22 | Sanofi Aventis | Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase |
CN101573354B (zh) | 2006-12-27 | 2014-02-12 | 塞诺菲-安万特股份有限公司 | 取代的异喹啉类及其作为Rho-激酶抑制剂的用途 |
EP2114920A1 (fr) | 2006-12-27 | 2009-11-11 | Sanofi-Aventis | Dérivés d'isoquinoline et d'isoquinolinone substitués |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
CN102131785B (zh) | 2008-06-24 | 2014-10-29 | 赛诺菲-安万特 | 6-取代的异喹啉和异喹啉酮 |
KR101692211B1 (ko) * | 2008-06-24 | 2017-01-03 | 사노피 | Rho 키나제 억제제로서의 비사이클릭 및 폴리사이클릭 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
CA2728137C (fr) * | 2008-06-24 | 2016-10-18 | Sanofi-Aventis | Isoquinolines et isoquinolinones substituees utilisees comme inhibiteurs de rho-kinase |
US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
WO2010104851A1 (fr) * | 2009-03-09 | 2010-09-16 | Surface Logix, Inc. | Inhibiteurs de la rho kinase |
EP3354643B1 (fr) | 2009-05-01 | 2020-10-28 | Aerie Pharmaceuticals, Inc. | Inhibiteurs à double mécanisme pour le traitement d'une maladie |
WO2012030910A1 (fr) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Dérivés de 2-cycloquinazoline et leurs méthodes d'utilisation |
BR112013017670B1 (pt) * | 2011-01-10 | 2022-07-19 | Infinity Pharmaceuticals, Inc | Processos de preparação de isoquinolinonas e formas sólidas de isoquinolinonas |
CN105209447B (zh) * | 2013-03-14 | 2017-11-21 | 百时美施贵宝公司 | 双环[2.2.2]酸gpr120调节剂 |
AR095036A1 (es) | 2013-03-14 | 2015-09-16 | Kalyra Pharmaceuticals Inc | Compuestos analgésicos bicíclicos |
CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
CA2907243C (fr) | 2013-03-15 | 2021-12-28 | Celgene Avilomics Research, Inc. | Composes de dihydropyrimidopyrimidinones substitues et leurs compositions pharmaceutiques utilisees en tant qu'inhibiteur du gene fgfr4 |
MX2015011514A (es) * | 2013-03-15 | 2016-08-11 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y sus usos. |
AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
DK3290407T3 (da) | 2013-10-18 | 2020-03-23 | Celgene Quanticel Res Inc | Bromodomæneinhibitorer |
WO2015089170A1 (fr) | 2013-12-12 | 2015-06-18 | Kalyra Pharmaceuticals, Inc. | Composés d'alkyle bicyclique et synthèse |
FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN106232567B (zh) | 2014-03-07 | 2021-11-02 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
CN106999451B (zh) | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
US10550087B2 (en) | 2015-11-17 | 2020-02-04 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
WO2017160926A1 (fr) * | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Composés analgésiques |
EP3445750A4 (fr) | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | Composés thérapeutiques |
US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
MX2019002396A (es) | 2016-08-31 | 2019-07-08 | Aerie Pharmaceuticals Inc | Composiciones oftalmicas. |
CN110506037A (zh) | 2017-03-31 | 2019-11-26 | 爱瑞制药公司 | 芳基环丙基-氨基-异喹啉酰胺化合物 |
US11242327B2 (en) | 2017-05-15 | 2022-02-08 | Recurium Ip Holdings, Llc | Analgesic compounds |
CA3112391A1 (fr) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Composes d'amide aryl cyclopropyl-amino-isoquinolinyl |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
HU178522B (en) * | 1979-04-11 | 1982-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing amino-isoquinoline derivatives |
EP0541559A1 (fr) | 1990-07-31 | 1993-05-19 | E.I. Du Pont De Nemours And Company | Equilibrage catalytique d'halocarbones selectionnes |
US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
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