MA31075B1 - Dérivés d'isoquinolone substitués par une cycloalkylamine. - Google Patents
Dérivés d'isoquinolone substitués par une cycloalkylamine.Info
- Publication number
- MA31075B1 MA31075B1 MA32036A MA32036A MA31075B1 MA 31075 B1 MA31075 B1 MA 31075B1 MA 32036 A MA32036 A MA 32036A MA 32036 A MA32036 A MA 32036A MA 31075 B1 MA31075 B1 MA 31075B1
- Authority
- MA
- Morocco
- Prior art keywords
- cycloalkylamine
- derivatives substituted
- isoquinolone derivatives
- rho
- kinase
- Prior art date
Links
- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical group C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 title abstract 2
- 102000000568 rho-Associated Kinases Human genes 0.000 abstract 2
- 108010041788 rho-Associated Kinases Proteins 0.000 abstract 2
- 102000011131 Myosin-Light-Chain Phosphatase Human genes 0.000 abstract 1
- 108010037801 Myosin-Light-Chain Phosphatase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
L'invention concerne des dérivés d'isoquinolone 6-substitués représentés par la formule (i), utilisés dans le traitement et/ou la prévention de maladies associées à la rho-kinase et/ou à la phosphorylation médiée par la rho-kinase de la phosphatase de la chaîne légère de la myosine, et des compositions contenant lesdits composés.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06026899 | 2006-12-27 | ||
PCT/EP2007/011164 WO2008077551A1 (fr) | 2006-12-27 | 2007-12-19 | Dérivés d'isoquinolone substitués par une cycloalkylamine |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31075B1 true MA31075B1 (fr) | 2010-01-04 |
Family
ID=38565513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32036A MA31075B1 (fr) | 2006-12-27 | 2009-06-24 | Dérivés d'isoquinolone substitués par une cycloalkylamine. |
Country Status (31)
Country | Link |
---|---|
US (1) | US8742116B2 (fr) |
EP (1) | EP2125745B1 (fr) |
JP (1) | JP5405314B2 (fr) |
KR (1) | KR101474228B1 (fr) |
CN (1) | CN101595094B (fr) |
AR (1) | AR064492A1 (fr) |
AU (1) | AU2007338407B2 (fr) |
BR (1) | BRPI0722064A2 (fr) |
CA (1) | CA2673917C (fr) |
CL (1) | CL2007003821A1 (fr) |
CO (1) | CO6210726A2 (fr) |
CR (1) | CR10813A (fr) |
DO (1) | DOP2009000164A (fr) |
EC (1) | ECSP099467A (fr) |
ES (1) | ES2625266T3 (fr) |
GT (1) | GT200900179A (fr) |
HK (1) | HK1139390A1 (fr) |
IL (1) | IL199540A (fr) |
MA (1) | MA31075B1 (fr) |
MX (1) | MX2009005966A (fr) |
MY (1) | MY155009A (fr) |
NI (1) | NI200900108A (fr) |
NO (1) | NO20092422L (fr) |
NZ (1) | NZ577980A (fr) |
RU (1) | RU2457203C2 (fr) |
SV (1) | SV2009003318A (fr) |
TN (1) | TN2009000269A1 (fr) |
TW (1) | TWI434689B (fr) |
UY (1) | UY30843A1 (fr) |
WO (1) | WO2008077551A1 (fr) |
ZA (1) | ZA200903551B (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101484435B1 (ko) | 2003-04-09 | 2015-01-19 | 가부시키가이샤 니콘 | 노광 방법 및 장치, 그리고 디바이스 제조 방법 |
TWI609409B (zh) | 2003-10-28 | 2017-12-21 | 尼康股份有限公司 | 照明光學裝置、曝光裝置、曝光方法以及元件製造方法 |
TWI385414B (zh) | 2003-11-20 | 2013-02-11 | 尼康股份有限公司 | 光學照明裝置、照明方法、曝光裝置、曝光方法以及元件製造方法 |
TWI505329B (zh) | 2004-02-06 | 2015-10-21 | 尼康股份有限公司 | 光學照明裝置、曝光裝置、曝光方法以及元件製造方法 |
ES2580108T3 (es) | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
CA2664335C (fr) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Inhibiteurs de la rho-kinase |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
EP2303845B1 (fr) * | 2008-06-24 | 2013-09-18 | Sanofi | Isoquinoléine substituée bi- et polycyclique et dérivés d'isoquinoléine utilisées comme inhibiteurs de la rho-kinase |
CN102131785B (zh) * | 2008-06-24 | 2014-10-29 | 赛诺菲-安万特 | 6-取代的异喹啉和异喹啉酮 |
JP5713893B2 (ja) * | 2008-06-24 | 2015-05-07 | サノフイ | Rho−キナーゼ阻害剤としての置換イソキノリン類及びイソキノリノン類 |
US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
EP3053913B1 (fr) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Inhibiteurs à double mécanisme pour le traitement d'une maladie |
CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
PL3640241T3 (pl) | 2013-10-18 | 2022-12-05 | Celgene Quanticel Research, Inc. | Inhibitory bromodomeny |
US9902702B2 (en) * | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
US9399194B2 (en) * | 2014-07-16 | 2016-07-26 | Battelle Energy Alliance, Llc | Methods for treating a liquid using draw solutions |
NZ733135A (en) | 2014-12-24 | 2018-06-29 | Gilead Sciences Inc | Fused pyrimidine compounds for the treatment of hiv |
TW202237569A (zh) | 2014-12-24 | 2022-10-01 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
BR112017013440A2 (pt) | 2014-12-24 | 2018-01-09 | Gilead Sciences, Inc. | compostos de isoquinolina para o tratamento de hiv |
AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
KR102579582B1 (ko) | 2015-11-17 | 2023-09-15 | 에어리 파마슈티컬즈, 인코포레이티드 | 키나아제 억제제 및 이의 중간체의 제조 방법 |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
AR107354A1 (es) * | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
MD3413892T2 (ro) * | 2016-02-12 | 2022-06-30 | Cytokinetics Inc | Derivați de tetrahidroizochinolină |
JP2019513804A (ja) | 2016-04-18 | 2019-05-30 | セルジーン クオンティセル リサーチ,インク. | 治療用化合物 |
US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
JP7061993B2 (ja) | 2016-07-08 | 2022-05-02 | ライジェル ファーマシューティカルズ, インコーポレイテッド | チロシンキナーゼ阻害剤 |
CA3035566A1 (fr) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Compositions ophtalmiques |
CN110506037A (zh) | 2017-03-31 | 2019-11-26 | 爱瑞制药公司 | 芳基环丙基-氨基-异喹啉酰胺化合物 |
CN110914257B (zh) * | 2017-07-12 | 2023-05-26 | 百时美施贵宝公司 | 作为rock抑制剂的螺庚基乙内酰脲 |
US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
AR125196A1 (es) | 2021-03-26 | 2023-06-21 | Novartis Ag | Derivados de ciclobutilo 1,3-sustituidos y sus usos |
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- 2007-12-19 AU AU2007338407A patent/AU2007338407B2/en not_active Ceased
- 2007-12-19 WO PCT/EP2007/011164 patent/WO2008077551A1/fr active Application Filing
- 2007-12-19 KR KR1020097013520A patent/KR101474228B1/ko not_active IP Right Cessation
- 2007-12-19 CN CN2007800485284A patent/CN101595094B/zh not_active Expired - Fee Related
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- 2007-12-19 BR BRPI0722064-2A2A patent/BRPI0722064A2/pt not_active IP Right Cessation
- 2007-12-19 RU RU2009128653/04A patent/RU2457203C2/ru not_active IP Right Cessation
- 2007-12-19 EP EP07856887.0A patent/EP2125745B1/fr active Active
- 2007-12-19 CA CA2673917A patent/CA2673917C/fr not_active Expired - Fee Related
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- 2007-12-19 ES ES07856887.0T patent/ES2625266T3/es active Active
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- 2009-06-18 US US12/487,479 patent/US8742116B2/en not_active Expired - Fee Related
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- 2009-06-24 IL IL199540A patent/IL199540A/en not_active IP Right Cessation
- 2009-06-24 MA MA32036A patent/MA31075B1/fr unknown
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