MD3413892T2 - Derivați de tetrahidroizochinolină - Google Patents
Derivați de tetrahidroizochinolinăInfo
- Publication number
- MD3413892T2 MD3413892T2 MDE20181214T MDE20181214T MD3413892T2 MD 3413892 T2 MD3413892 T2 MD 3413892T2 MD E20181214 T MDE20181214 T MD E20181214T MD E20181214 T MDE20181214 T MD E20181214T MD 3413892 T2 MD3413892 T2 MD 3413892T2
- Authority
- MD
- Moldova
- Prior art keywords
- muscle
- troponin
- disorders
- tetrahydroisoquinoline
- modulating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
- C12N2509/10—Mechanical dissociation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Cell Biology (AREA)
- Child & Adolescent Psychology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Noi compuşi derivaţi de tetrahidroizochinolină sunt dezvăluiţi aici care pot fi utilizaţi ca ingredient activ pentru o compoziţie farmaceutică utilă pentru prevenirea sau tratarea unei boli sau afecţiuni care răspunde la modularea contractilităţii sarcomerului scheletic. Aceasta poate fi realizată de exemplu, prin modularea complexului de troponină al sarcomerului muşchiului scheletic rapid prin una sau mai multe dintre miozina scheletică rapidă, actină, tropomiozină, troponină C, troponină I, şi troponină T, şi fragmente şi izoforme ale acestora. Compuşii derivat de tetrahidroizochinolină pot fi astfel utilizaţi ca agent pentru prevenirea sau tratarea 1) tulburărilor neuromusculare, 2) tulburărilor muşchiului voluntar, 3) tulburărilor SNC în care slăbiciunea, atrofia şi oboseala musculare sunt simptome proeminente, 4) simptomelor musculare care iau naştere din tulburări sistemice, şi 5) disfuncţii ale planşeului pelvian şi muşchiului sfincter uretral/anal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662285039P | 2016-02-12 | 2016-02-12 | |
PCT/US2017/017295 WO2017139526A1 (en) | 2016-02-12 | 2017-02-10 | Tetrahydroisoquinoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MD3413892T2 true MD3413892T2 (ro) | 2022-06-30 |
Family
ID=59561239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20181214T MD3413892T2 (ro) | 2016-02-12 | 2017-02-10 | Derivați de tetrahidroizochinolină |
Country Status (31)
Country | Link |
---|---|
US (5) | US9914741B2 (ro) |
EP (2) | EP4032877A1 (ro) |
JP (2) | JP6832943B2 (ro) |
KR (1) | KR20180120701A (ro) |
CN (2) | CN113666938A (ro) |
AR (1) | AR107592A1 (ro) |
AU (1) | AU2017217663B2 (ro) |
BR (1) | BR112018016475A2 (ro) |
CA (1) | CA3012839A1 (ro) |
CL (1) | CL2018002287A1 (ro) |
CO (1) | CO2018007920A2 (ro) |
DK (1) | DK3413892T3 (ro) |
ES (1) | ES2913423T3 (ro) |
HR (1) | HRP20220655T1 (ro) |
HU (1) | HUE058820T2 (ro) |
IL (1) | IL261055B (ro) |
LT (1) | LT3413892T (ro) |
MA (1) | MA44018B1 (ro) |
MD (1) | MD3413892T2 (ro) |
MX (1) | MX2018009759A (ro) |
NZ (1) | NZ746311A (ro) |
PH (1) | PH12018501694A1 (ro) |
PL (1) | PL3413892T3 (ro) |
PT (1) | PT3413892T (ro) |
RS (1) | RS63240B1 (ro) |
RU (1) | RU2743424C2 (ro) |
SG (1) | SG11201806416XA (ro) |
SI (1) | SI3413892T1 (ro) |
TW (2) | TWI773118B (ro) |
UA (1) | UA124879C2 (ro) |
WO (1) | WO2017139526A1 (ro) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI773118B (zh) * | 2016-02-12 | 2022-08-01 | 美商細胞動力學股份有限公司 | 四氫異喹啉衍生物 |
CN116635378A (zh) | 2020-11-06 | 2023-08-22 | 赛特凯恩蒂克公司 | 二环1,4-二氮杂环庚酮和其治疗用途 |
Family Cites Families (34)
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US3301857A (en) | 1963-08-26 | 1967-01-31 | Hoffmann La Roche | Spiro |
SE368009B (ro) | 1971-09-16 | 1974-06-17 | Kabi Ab | |
ATE232863T1 (de) | 1996-08-06 | 2003-03-15 | Pfizer | Substituierte pyrido- oder pyrimidogruppen enthaltende 6,6- oder 6,7-bicyclische derivate |
KR100567649B1 (ko) | 1996-09-25 | 2006-04-05 | 아스트라제네카 유케이 리미티드 | 혈관 내피 성장 인자와 같은 성장 인자의 효과를 억제하는 퀴놀린 유도체 |
US6410254B1 (en) | 1999-05-18 | 2002-06-25 | Cytokinetics | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
US6743599B1 (en) | 1999-05-18 | 2004-06-01 | Cytokinetics, Inc. | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
US7202051B1 (en) | 1999-05-18 | 2007-04-10 | Cytokinetics, Inc. | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
JP2001106673A (ja) | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
AU6314900A (en) | 1999-07-26 | 2001-02-13 | Banyu Pharmaceutical Co., Ltd. | Biarylurea derivatives |
GB0321538D0 (en) | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
RS50756B (sr) | 2004-04-28 | 2010-08-31 | Takeda Pharmaceutical Company Limited | Fuzionisani derivati hinolina i njegova upotreba |
BRPI0620151A2 (pt) * | 2005-12-22 | 2010-06-29 | Wyeth Corp | composto; composição farmacêutica; método de tratar ou inibir o crescimento de células tumorais cancerosas em um mamìfero que deste necessita; método; e processo |
GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
ES2558517T3 (es) * | 2006-08-02 | 2016-02-04 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas |
EP2125745B1 (en) | 2006-12-27 | 2017-02-22 | Sanofi | Cycloalkylamine substituted isoquinolone derivatives |
JP5197606B2 (ja) | 2007-01-05 | 2013-05-15 | 第一三共株式会社 | フューズ置換型アミノピロリジン誘導体 |
US8163909B2 (en) | 2007-05-25 | 2012-04-24 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
EP2265588B1 (en) * | 2008-02-27 | 2013-06-26 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF 11ß -HYDROXYSTEROID DEHYDROGENASE TYPE 1 |
CN101518971B (zh) * | 2008-02-29 | 2012-07-18 | E.I.内穆尔杜邦公司 | 聚酯叠层膜和使用该叠层膜的太阳能电池板 |
MX2011004535A (es) | 2008-10-29 | 2011-11-18 | Deciphera Pharmaceuticals Llc | Ciclopropanamidas y analogos que exhiben actividades anti-cancer y anti-proliferativas. |
WO2010131147A1 (en) | 2009-05-12 | 2010-11-18 | Pfizer Limited | Cyclobutenedione derivatives |
EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
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HUP1100241A3 (en) | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
CN108553467A (zh) | 2012-04-02 | 2018-09-21 | 赛特凯恩蒂克公司 | 改善膈肌功能的方法 |
KR102163931B1 (ko) | 2012-04-11 | 2020-10-12 | 싸이토키네틱스, 인코포레이티드 | 골격근 피로에 대한 저항을 개선 |
AR091699A1 (es) | 2012-07-10 | 2015-02-25 | Astellas Pharma Inc | Derivado de indol carboxamida |
SI3137622T1 (sl) | 2014-04-29 | 2022-05-31 | Cytokinetics, Inc. | Postopki za zmanjšanje upada vitalne kapacitete |
ES2750751T3 (es) | 2014-09-09 | 2020-03-27 | Astellas Pharma Inc | Composición farmacéutica novedosa para la prevención y/o el tratamiento de la incontinencia urinaria |
TWI773118B (zh) | 2016-02-12 | 2022-08-01 | 美商細胞動力學股份有限公司 | 四氫異喹啉衍生物 |
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2017
- 2017-02-10 TW TW110103986A patent/TWI773118B/zh active
- 2017-02-10 TW TW106104493A patent/TWI719138B/zh active
- 2017-02-10 HU HUE17750801A patent/HUE058820T2/hu unknown
- 2017-02-10 CA CA3012839A patent/CA3012839A1/en active Pending
- 2017-02-10 EP EP22160176.8A patent/EP4032877A1/en active Pending
- 2017-02-10 US US15/429,738 patent/US9914741B2/en active Active
- 2017-02-10 UA UAA201809258A patent/UA124879C2/uk unknown
- 2017-02-10 DK DK17750801.7T patent/DK3413892T3/da active
- 2017-02-10 CN CN202110837700.6A patent/CN113666938A/zh active Pending
- 2017-02-10 RS RS20220483A patent/RS63240B1/sr unknown
- 2017-02-10 MD MDE20181214T patent/MD3413892T2/ro unknown
- 2017-02-10 NZ NZ746311A patent/NZ746311A/en unknown
- 2017-02-10 SI SI201731142T patent/SI3413892T1/sl unknown
- 2017-02-10 EP EP17750801.7A patent/EP3413892B1/en active Active
- 2017-02-10 JP JP2018541693A patent/JP6832943B2/ja active Active
- 2017-02-10 HR HRP20220655TT patent/HRP20220655T1/hr unknown
- 2017-02-10 AU AU2017217663A patent/AU2017217663B2/en active Active
- 2017-02-10 AR ARP170100336A patent/AR107592A1/es unknown
- 2017-02-10 PT PT177508017T patent/PT3413892T/pt unknown
- 2017-02-10 RU RU2018130002A patent/RU2743424C2/ru active
- 2017-02-10 ES ES17750801T patent/ES2913423T3/es active Active
- 2017-02-10 LT LTEPPCT/US2017/017295T patent/LT3413892T/lt unknown
- 2017-02-10 BR BR112018016475A patent/BR112018016475A2/pt active Search and Examination
- 2017-02-10 SG SG11201806416XA patent/SG11201806416XA/en unknown
- 2017-02-10 PL PL17750801T patent/PL3413892T3/pl unknown
- 2017-02-10 KR KR1020187026486A patent/KR20180120701A/ko not_active Application Discontinuation
- 2017-02-10 MA MA44018A patent/MA44018B1/fr unknown
- 2017-02-10 MX MX2018009759A patent/MX2018009759A/es unknown
- 2017-02-10 WO PCT/US2017/017295 patent/WO2017139526A1/en active Application Filing
- 2017-02-10 CN CN201780010949.1A patent/CN109069498B/zh active Active
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2018
- 2018-01-17 US US15/873,571 patent/US10259821B2/en active Active
- 2018-07-30 CO CONC2018/0007920A patent/CO2018007920A2/es unknown
- 2018-08-08 IL IL261055A patent/IL261055B/en active IP Right Grant
- 2018-08-09 PH PH12018501694A patent/PH12018501694A1/en unknown
- 2018-08-10 CL CL2018002287A patent/CL2018002287A1/es unknown
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2019
- 2019-03-04 US US16/291,481 patent/US10689393B2/en active Active
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2020
- 2020-05-11 US US16/871,532 patent/US11479561B2/en active Active
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2021
- 2021-02-01 JP JP2021014223A patent/JP7137650B2/ja active Active
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2022
- 2022-09-13 US US17/944,060 patent/US20230125280A1/en active Pending
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