MA44018B1 - Dérivés de tétrahydroisoquinoline - Google Patents
Dérivés de tétrahydroisoquinolineInfo
- Publication number
- MA44018B1 MA44018B1 MA44018A MA44018A MA44018B1 MA 44018 B1 MA44018 B1 MA 44018B1 MA 44018 A MA44018 A MA 44018A MA 44018 A MA44018 A MA 44018A MA 44018 B1 MA44018 B1 MA 44018B1
- Authority
- MA
- Morocco
- Prior art keywords
- muscle
- troponin
- disorders
- tetrahydroisoquinoline
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
- C12N2509/10—Mechanical dissociation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Cell Biology (AREA)
- Child & Adolescent Psychology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne de nouveaux composés dérivés de la tétrahydroisoquinoline qui peuvent être utilisés à titre de principe actif pour une composition pharmaceutique, et en particulier, pour une composition pharmaceutique utile pour prévenir ou traiter une maladie ou une affection sensible à la modulation de la contractilité du sarcomère squelettique. L'objectif est atteint, par exemple, par modulation du complexe de troponine du sarcomère du muscle squelettique rapide par l'intermédiaire d'un ou de plusieurs des filaments suivants : myosine squelettique rapide, actine, tropomyosine, troponine c, troponine i et troponine t, leurs fragments et isoformes. Les composés dérivés de la tétrahydroisoquinoline peuvent ainsi être utilisés comme agent pour prévenir ou traiter 1) les troubles neuromusculaires, 2) les troubles du muscle volontaire, 3) les troubles du snc dans lesquels la faiblesse, l'atrophie, et la fatigue musculaires sont des symptômes importants, 4) les symptômes musculaires provenant de troubles systémiques, et 5) les dysfonctions du plancher pelvien et du muscle sphincter urétral/anal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662285039P | 2016-02-12 | 2016-02-12 | |
PCT/US2017/017295 WO2017139526A1 (fr) | 2016-02-12 | 2017-02-10 | Dérivés de tétrahydroisoquinoline |
Publications (2)
Publication Number | Publication Date |
---|---|
MA44018A MA44018A (fr) | 2018-12-19 |
MA44018B1 true MA44018B1 (fr) | 2022-05-31 |
Family
ID=59561239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA44018A MA44018B1 (fr) | 2016-02-12 | 2017-02-10 | Dérivés de tétrahydroisoquinoline |
Country Status (32)
Country | Link |
---|---|
US (5) | US9914741B2 (fr) |
EP (2) | EP3413892B1 (fr) |
JP (2) | JP6832943B2 (fr) |
KR (1) | KR20180120701A (fr) |
CN (2) | CN109069498B (fr) |
AR (1) | AR107592A1 (fr) |
AU (1) | AU2017217663B2 (fr) |
BR (1) | BR112018016475A2 (fr) |
CA (1) | CA3012839A1 (fr) |
CL (1) | CL2018002287A1 (fr) |
CO (1) | CO2018007920A2 (fr) |
DK (1) | DK3413892T3 (fr) |
ES (1) | ES2913423T3 (fr) |
HR (1) | HRP20220655T1 (fr) |
HU (1) | HUE058820T2 (fr) |
IL (1) | IL261055B (fr) |
LT (1) | LT3413892T (fr) |
MA (1) | MA44018B1 (fr) |
MD (1) | MD3413892T2 (fr) |
MX (1) | MX2018009759A (fr) |
NZ (1) | NZ746311A (fr) |
PH (1) | PH12018501694A1 (fr) |
PL (1) | PL3413892T3 (fr) |
PT (1) | PT3413892T (fr) |
RS (1) | RS63240B1 (fr) |
RU (1) | RU2743424C2 (fr) |
SG (1) | SG11201806416XA (fr) |
SI (1) | SI3413892T1 (fr) |
TW (2) | TWI719138B (fr) |
UA (1) | UA124879C2 (fr) |
WO (1) | WO2017139526A1 (fr) |
ZA (1) | ZA201804947B (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20220655T1 (hr) * | 2016-02-12 | 2022-06-24 | Cytokinetics, Incorporated | Tetrahidroizokinolinski derivati |
WO2022099011A1 (fr) | 2020-11-06 | 2022-05-12 | Cytokinetics, Inc. | 1,4-diazépanones bicycliques et leurs utilisations thérapeutiques |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3301857A (en) | 1963-08-26 | 1967-01-31 | Hoffmann La Roche | Spiro |
SE368009B (fr) | 1971-09-16 | 1974-06-17 | Kabi Ab | |
PL331602A1 (en) * | 1996-08-06 | 1999-08-02 | Pfizer | Pyrido- or pyrimido-substituted 6,6- or 6,7-bicyclic derivatives |
IL128994A (en) | 1996-09-25 | 2004-12-15 | Zeneca Ltd | History of quinoline and naphthyridine and their salts, processes for their preparation, pharmaceutical preparations containing them and their use as medicines |
US6410254B1 (en) | 1999-05-18 | 2002-06-25 | Cytokinetics | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
US7202051B1 (en) | 1999-05-18 | 2007-04-10 | Cytokinetics, Inc. | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
US6743599B1 (en) | 1999-05-18 | 2004-06-01 | Cytokinetics, Inc. | Compositions and assays utilizing ADP or phosphate for detecting protein modulators |
WO2001007411A1 (fr) * | 1999-07-26 | 2001-02-01 | Banyu Pharmaceutical Co., Ltd. | Derives de biaryluree |
JP2001106673A (ja) | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
GB0321538D0 (en) | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
CA2565018A1 (fr) * | 2004-04-28 | 2005-11-10 | Takeda Pharmaceutical Company Limited | Derive de quinoline fusionnee et utilisation de celui-ci |
AU2006331765A1 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3(2H)-isoquinolones and use thereof as kinase inhibitor |
GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
PT2583970E (pt) * | 2006-08-02 | 2016-02-08 | Cytokinetics Inc | Certas entidades químicas, composições e métodos compreendendo imidazopirimidinas |
NZ577980A (en) * | 2006-12-27 | 2012-01-12 | Sanofi Aventis | Cycloalkylamine substituted isoquinolone derivatives |
MY162052A (en) | 2007-01-05 | 2017-05-31 | Daiichi Sankyo Co Ltd | Fused substitute aminopyrrolidine derivative |
WO2008147547A1 (fr) | 2007-05-25 | 2008-12-04 | Amgen Inc. | Composés d'hydroxyéthylamine substitués en tant que modulateurs de la bêta-sécrétase et procédés d'utilisation |
WO2009108332A1 (fr) * | 2008-02-27 | 2009-09-03 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de la 11β-hydroxystéroïde déshydrogénase de type 1 |
CN101518971B (zh) * | 2008-02-29 | 2012-07-18 | E.I.内穆尔杜邦公司 | 聚酯叠层膜和使用该叠层膜的太阳能电池板 |
WO2010038901A1 (fr) * | 2008-10-02 | 2010-04-08 | Taisho Pharmaceutical Co., Ltd. | Dérivé de 7-pipéridinoalkyle-3,4-dihydroquinolone |
MX2011004535A (es) | 2008-10-29 | 2011-11-18 | Deciphera Pharmaceuticals Llc | Ciclopropanamidas y analogos que exhiben actividades anti-cancer y anti-proliferativas. |
WO2010131146A1 (fr) | 2009-05-12 | 2010-11-18 | Pfizer Limited | Dérivés de cyclobutène-dione |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
EP2560488B1 (fr) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Aminopyridines et aminotriazines, leurs compositions et leurs procédés d'utilisation |
AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
EP2582698B1 (fr) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Hétérocycles à 5, 6 et 7 chaînons substitués, médicaments contenant ces composés et leur utilisation |
BR112013021180A2 (pt) | 2011-02-18 | 2019-09-24 | Allergan Inc | derivados de 6,7-dialcóxi-3-isoquinolinol substituído como inibidores de fosfodiesterase 10 (pde10a) |
US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
HUP1100241A3 (en) * | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
SG11201406270YA (en) | 2012-04-02 | 2014-10-30 | Cytokinetics Inc | Methods for improving diaphragm function |
EP2836590A4 (fr) | 2012-04-11 | 2016-04-13 | Cytokinetics Inc | Procédés d'amélioration de la résistance à la fatigue des muscles du squelette |
AR091699A1 (es) * | 2012-07-10 | 2015-02-25 | Astellas Pharma Inc | Derivado de indol carboxamida |
HRP20220183T1 (hr) | 2014-04-29 | 2022-04-29 | Cytokinetics, Inc. | Postupci smanjivanja propadanja vitalnog kapaciteta |
PT3192512T (pt) | 2014-09-09 | 2019-10-29 | Cytokinetics Inc | Nova composição farmacêutica para prevenção e/ou tratamento de incontinência urinária |
HRP20220655T1 (hr) * | 2016-02-12 | 2022-06-24 | Cytokinetics, Incorporated | Tetrahidroizokinolinski derivati |
-
2017
- 2017-02-10 HR HRP20220655TT patent/HRP20220655T1/hr unknown
- 2017-02-10 NZ NZ746311A patent/NZ746311A/en unknown
- 2017-02-10 WO PCT/US2017/017295 patent/WO2017139526A1/fr active Application Filing
- 2017-02-10 RU RU2018130002A patent/RU2743424C2/ru active
- 2017-02-10 ES ES17750801T patent/ES2913423T3/es active Active
- 2017-02-10 KR KR1020187026486A patent/KR20180120701A/ko not_active Application Discontinuation
- 2017-02-10 SI SI201731142T patent/SI3413892T1/sl unknown
- 2017-02-10 MX MX2018009759A patent/MX2018009759A/es unknown
- 2017-02-10 LT LTEPPCT/US2017/017295T patent/LT3413892T/lt unknown
- 2017-02-10 SG SG11201806416XA patent/SG11201806416XA/en unknown
- 2017-02-10 DK DK17750801.7T patent/DK3413892T3/da active
- 2017-02-10 JP JP2018541693A patent/JP6832943B2/ja active Active
- 2017-02-10 EP EP17750801.7A patent/EP3413892B1/fr active Active
- 2017-02-10 AR ARP170100336A patent/AR107592A1/es unknown
- 2017-02-10 CA CA3012839A patent/CA3012839A1/fr active Pending
- 2017-02-10 CN CN201780010949.1A patent/CN109069498B/zh active Active
- 2017-02-10 MA MA44018A patent/MA44018B1/fr unknown
- 2017-02-10 AU AU2017217663A patent/AU2017217663B2/en active Active
- 2017-02-10 BR BR112018016475A patent/BR112018016475A2/pt active Search and Examination
- 2017-02-10 CN CN202110837700.6A patent/CN113666938A/zh active Pending
- 2017-02-10 EP EP22160176.8A patent/EP4032877A1/fr active Pending
- 2017-02-10 MD MDE20181214T patent/MD3413892T2/ro unknown
- 2017-02-10 RS RS20220483A patent/RS63240B1/sr unknown
- 2017-02-10 TW TW106104493A patent/TWI719138B/zh active
- 2017-02-10 US US15/429,738 patent/US9914741B2/en active Active
- 2017-02-10 PL PL17750801T patent/PL3413892T3/pl unknown
- 2017-02-10 PT PT177508017T patent/PT3413892T/pt unknown
- 2017-02-10 HU HUE17750801A patent/HUE058820T2/hu unknown
- 2017-02-10 UA UAA201809258A patent/UA124879C2/uk unknown
- 2017-02-10 TW TW110103986A patent/TWI773118B/zh active
-
2018
- 2018-01-17 US US15/873,571 patent/US10259821B2/en active Active
- 2018-07-23 ZA ZA2018/04947A patent/ZA201804947B/en unknown
- 2018-07-30 CO CONC2018/0007920A patent/CO2018007920A2/es unknown
- 2018-08-08 IL IL261055A patent/IL261055B/en active IP Right Grant
- 2018-08-09 PH PH12018501694A patent/PH12018501694A1/en unknown
- 2018-08-10 CL CL2018002287A patent/CL2018002287A1/es unknown
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2019
- 2019-03-04 US US16/291,481 patent/US10689393B2/en active Active
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2020
- 2020-05-11 US US16/871,532 patent/US11479561B2/en active Active
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2021
- 2021-02-01 JP JP2021014223A patent/JP7137650B2/ja active Active
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2022
- 2022-09-13 US US17/944,060 patent/US20230125280A1/en not_active Abandoned
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