CO2018007920A2 - Derivados de tetrahidroisoquinolina - Google Patents

Derivados de tetrahidroisoquinolina

Info

Publication number
CO2018007920A2
CO2018007920A2 CONC2018/0007920A CO2018007920A CO2018007920A2 CO 2018007920 A2 CO2018007920 A2 CO 2018007920A2 CO 2018007920 A CO2018007920 A CO 2018007920A CO 2018007920 A2 CO2018007920 A2 CO 2018007920A2
Authority
CO
Colombia
Prior art keywords
muscle
troponin
disorders
tetrahydroisoquinoline
pharmaceutical composition
Prior art date
Application number
CONC2018/0007920A
Other languages
English (en)
Inventor
Hiroaki Tanaka
Ippei Sato
Takashi Kamikubo
Masanori Miura
Yuji Matsushima
Yasuhiro Shiina
Susumu Yamaki
Tomoyuki Saito
Hiroshi Kiyohara
Munemichi OHE
Kayoko Mihara
Bradley Paul Morgan
Fady Malik
Scott Emile Collibee
Pu-Ping Lu
Jeffrey Michael Warrington
Marc Garard
Luke Ashcraft
Original Assignee
Cytokinetics Inc
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc, Astellas Pharma Inc filed Critical Cytokinetics Inc
Publication of CO2018007920A2 publication Critical patent/CO2018007920A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

RESUMEN Compuestos novedosos derivados de tetrahidroisoquinolina que pueden usarse como un ingrediente activo para una composición farmacéutica, y en particular, para una composición farmacéutica útil para prevenir o tratar una enfermedad o condición que responde a la modulación de la contractilidad del sarcómero esquelético. Esto puede lograrse, por ejemplo, por modulación del complejo de troponina del sarcómero de músculo esquelético rápido mediante una o más de miosina esquelética rápida, actina, tropomiosina, troponina C, troponina I, y troponina T, y fragmentos e isoformas de las mismas. Los compuestos derivados de tetrahidroisoquinolina pueden usarse entonces como agente para prevenir o tratar 1) trastornos neuromusculares, 2) trastornos de músculos voluntarios, 3) trastornos del SNC en los cuales la debilidad muscular, atrofia, y fatiga son síntomas prominentes, 4) síntomas musculares que derivan de trastornos sistémicos, y 5) disfunciones del piso pélvico y del músculo del esfínter uretral/anal.
CONC2018/0007920A 2016-02-12 2018-07-30 Derivados de tetrahidroisoquinolina CO2018007920A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662285039P 2016-02-12 2016-02-12
PCT/US2017/017295 WO2017139526A1 (en) 2016-02-12 2017-02-10 Tetrahydroisoquinoline derivatives

Publications (1)

Publication Number Publication Date
CO2018007920A2 true CO2018007920A2 (es) 2018-12-14

Family

ID=59561239

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0007920A CO2018007920A2 (es) 2016-02-12 2018-07-30 Derivados de tetrahidroisoquinolina

Country Status (31)

Country Link
US (5) US9914741B2 (es)
EP (2) EP4032877A1 (es)
JP (2) JP6832943B2 (es)
KR (1) KR20180120701A (es)
CN (2) CN113666938A (es)
AR (1) AR107592A1 (es)
AU (1) AU2017217663B2 (es)
BR (1) BR112018016475A2 (es)
CA (1) CA3012839A1 (es)
CL (1) CL2018002287A1 (es)
CO (1) CO2018007920A2 (es)
DK (1) DK3413892T3 (es)
ES (1) ES2913423T3 (es)
HR (1) HRP20220655T1 (es)
HU (1) HUE058820T2 (es)
IL (1) IL261055B (es)
LT (1) LT3413892T (es)
MA (1) MA44018B1 (es)
MD (1) MD3413892T2 (es)
MX (1) MX2018009759A (es)
NZ (1) NZ746311A (es)
PH (1) PH12018501694A1 (es)
PL (1) PL3413892T3 (es)
PT (1) PT3413892T (es)
RS (1) RS63240B1 (es)
RU (1) RU2743424C2 (es)
SG (1) SG11201806416XA (es)
SI (1) SI3413892T1 (es)
TW (2) TWI773118B (es)
UA (1) UA124879C2 (es)
WO (1) WO2017139526A1 (es)

Families Citing this family (2)

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TWI773118B (zh) * 2016-02-12 2022-08-01 美商細胞動力學股份有限公司 四氫異喹啉衍生物
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Also Published As

Publication number Publication date
WO2017139526A1 (en) 2017-08-17
CN109069498B (zh) 2021-08-17
IL261055A (en) 2018-10-31
EP3413892B1 (en) 2022-04-20
BR112018016475A2 (pt) 2018-12-26
JP7137650B2 (ja) 2022-09-14
ES2913423T3 (es) 2022-06-02
TW202138373A (zh) 2021-10-16
US9914741B2 (en) 2018-03-13
MA44018A (fr) 2018-12-19
RU2018130002A (ru) 2020-03-12
JP2021073270A (ja) 2021-05-13
AR107592A1 (es) 2018-05-16
WO2017139526A8 (en) 2018-08-16
DK3413892T3 (da) 2022-05-23
AU2017217663A1 (en) 2018-10-04
IL261055B (en) 2021-03-25
RU2018130002A3 (es) 2020-03-24
SG11201806416XA (en) 2018-08-30
CA3012839A1 (en) 2017-08-17
US20200270266A1 (en) 2020-08-27
HUE058820T2 (hu) 2022-09-28
MA44018B1 (fr) 2022-05-31
TWI773118B (zh) 2022-08-01
CN109069498A (zh) 2018-12-21
EP3413892A1 (en) 2018-12-19
EP3413892A4 (en) 2019-08-14
US11479561B2 (en) 2022-10-25
MX2018009759A (es) 2018-11-29
RU2743424C2 (ru) 2021-02-18
US10259821B2 (en) 2019-04-16
AU2017217663B2 (en) 2021-06-17
MD3413892T2 (ro) 2022-06-30
PH12018501694A1 (en) 2019-01-28
CL2018002287A1 (es) 2019-01-04
US20180148458A1 (en) 2018-05-31
TWI719138B (zh) 2021-02-21
US20190194220A1 (en) 2019-06-27
TW201741316A (zh) 2017-12-01
PT3413892T (pt) 2022-05-30
US10689393B2 (en) 2020-06-23
UA124879C2 (uk) 2021-12-08
JP2019509267A (ja) 2019-04-04
LT3413892T (lt) 2022-06-10
JP6832943B2 (ja) 2021-02-24
NZ746311A (en) 2022-08-26
EP4032877A1 (en) 2022-07-27
US20230125280A1 (en) 2023-04-27
US20170233402A1 (en) 2017-08-17
HRP20220655T1 (hr) 2022-06-24
CN113666938A (zh) 2021-11-19
PL3413892T3 (pl) 2022-06-13
KR20180120701A (ko) 2018-11-06
SI3413892T1 (sl) 2022-06-30
RS63240B1 (sr) 2022-06-30

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