ZA200710952B - Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors - Google Patents

Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors

Info

Publication number
ZA200710952B
ZA200710952B ZA200710952A ZA200710952A ZA200710952B ZA 200710952 B ZA200710952 B ZA 200710952B ZA 200710952 A ZA200710952 A ZA 200710952A ZA 200710952 A ZA200710952 A ZA 200710952A ZA 200710952 B ZA200710952 B ZA 200710952B
Authority
ZA
South Africa
Prior art keywords
cyclohexylamin
rho
kinase inhibitors
isoquinolone derivatives
isoquinolone
Prior art date
Application number
ZA200710952A
Other languages
English (en)
Inventor
Plettenburg Oliver
Hofmeister Armin
Kadereit Dieter
Brendel Joachim
Loehn Matthias
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ZA200710952B publication Critical patent/ZA200710952B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
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ZA200710952A 2005-07-26 2007-12-18 Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors ZA200710952B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05016153 2005-07-26

Publications (1)

Publication Number Publication Date
ZA200710952B true ZA200710952B (en) 2008-11-26

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ID=35115842

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710952A ZA200710952B (en) 2005-07-26 2007-12-18 Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors

Country Status (37)

Country Link
US (2) US8609691B2 (fr)
EP (1) EP1912949B1 (fr)
JP (1) JP5049970B2 (fr)
KR (1) KR101336678B1 (fr)
CN (1) CN101228132B (fr)
AR (1) AR057082A1 (fr)
AT (1) ATE521595T1 (fr)
AU (1) AU2006274246B2 (fr)
BR (1) BRPI0614063A2 (fr)
CA (1) CA2615663C (fr)
CR (1) CR9604A (fr)
CY (1) CY1112085T1 (fr)
DK (1) DK1912949T3 (fr)
DO (1) DOP2006000177A (fr)
EC (1) ECSP088136A (fr)
ES (1) ES2372067T3 (fr)
GT (1) GT200600327A (fr)
HK (1) HK1123036A1 (fr)
HN (1) HN2008000130A (fr)
HR (1) HRP20110839T1 (fr)
IL (1) IL188949A (fr)
MA (1) MA29639B1 (fr)
MX (1) MX2008000956A (fr)
MY (1) MY146644A (fr)
NI (1) NI200800024A (fr)
NO (1) NO20080965L (fr)
NZ (1) NZ565669A (fr)
PE (1) PE20070181A1 (fr)
PL (1) PL1912949T3 (fr)
PT (1) PT1912949E (fr)
RS (1) RS52241B (fr)
RU (1) RU2440988C2 (fr)
SI (1) SI1912949T1 (fr)
TN (1) TNSN08038A1 (fr)
TW (1) TWI412521B (fr)
WO (1) WO2007012422A1 (fr)
ZA (1) ZA200710952B (fr)

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BRPI0613861B8 (pt) 2005-07-26 2021-05-25 Sanofi Aventis derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase
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WO2015060373A1 (fr) * 2013-10-23 2015-04-30 中外製薬株式会社 Dérivé de quinazolinone et d'isoquinolinone
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
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AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
WO2016180918A1 (fr) 2015-05-12 2016-11-17 Platod Combinaison de caractéristiques pharmacologiques et microfluidiques pour production améliorée de plaquettes
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US8796458B2 (en) 2014-08-05
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AU2006274246B2 (en) 2012-07-12
WO2007012422A1 (fr) 2007-02-01
DK1912949T3 (da) 2011-11-28
NZ565669A (en) 2010-05-28
AR057082A1 (es) 2007-11-14
CA2615663A1 (fr) 2007-02-01
MX2008000956A (es) 2008-03-27
TNSN08038A1 (en) 2009-07-14
ATE521595T1 (de) 2011-09-15
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BRPI0614063A2 (pt) 2011-03-09
CN101228132A (zh) 2008-07-23
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RS52241B (en) 2012-10-31
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