DK1912949T3 - Cyclohexylaminisoquinolon-derivater som inhibitorer af rho-kinase - Google Patents
Cyclohexylaminisoquinolon-derivater som inhibitorer af rho-kinaseInfo
- Publication number
- DK1912949T3 DK1912949T3 DK06776307.8T DK06776307T DK1912949T3 DK 1912949 T3 DK1912949 T3 DK 1912949T3 DK 06776307 T DK06776307 T DK 06776307T DK 1912949 T3 DK1912949 T3 DK 1912949T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclohexylamine
- rho
- kinase
- inhibitors
- isoquinolone derivatives
- Prior art date
Links
- PAFZNILMFXTMIY-UHFFFAOYSA-N Cyclohexylamine Natural products NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 title 1
- -1 Cyclohexylamine isoquinolone derivatives Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000000568 rho-Associated Kinases Human genes 0.000 title 1
- 108010041788 rho-Associated Kinases Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05016153 | 2005-07-26 | ||
| PCT/EP2006/007140 WO2007012422A1 (en) | 2005-07-26 | 2006-07-20 | Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1912949T3 true DK1912949T3 (da) | 2011-11-28 |
Family
ID=35115842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06776307.8T DK1912949T3 (da) | 2005-07-26 | 2006-07-20 | Cyclohexylaminisoquinolon-derivater som inhibitorer af rho-kinase |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US8609691B2 (da) |
| EP (1) | EP1912949B1 (da) |
| JP (1) | JP5049970B2 (da) |
| KR (1) | KR101336678B1 (da) |
| CN (1) | CN101228132B (da) |
| AR (1) | AR057082A1 (da) |
| AT (1) | ATE521595T1 (da) |
| AU (1) | AU2006274246B2 (da) |
| BR (1) | BRPI0614063A2 (da) |
| CA (1) | CA2615663C (da) |
| CR (1) | CR9604A (da) |
| CY (1) | CY1112085T1 (da) |
| DK (1) | DK1912949T3 (da) |
| DO (1) | DOP2006000177A (da) |
| EC (1) | ECSP088136A (da) |
| ES (1) | ES2372067T3 (da) |
| GT (1) | GT200600327A (da) |
| HK (1) | HK1123036A1 (da) |
| HN (1) | HN2008000130A (da) |
| HR (1) | HRP20110839T1 (da) |
| IL (1) | IL188949A (da) |
| MA (1) | MA29639B1 (da) |
| MX (1) | MX2008000956A (da) |
| MY (1) | MY146644A (da) |
| NI (1) | NI200800024A (da) |
| NO (1) | NO20080965L (da) |
| NZ (1) | NZ565669A (da) |
| PE (1) | PE20070181A1 (da) |
| PL (1) | PL1912949T3 (da) |
| PT (1) | PT1912949E (da) |
| RS (1) | RS52241B (da) |
| RU (1) | RU2440988C2 (da) |
| SI (1) | SI1912949T1 (da) |
| TN (1) | TNSN08038A1 (da) |
| TW (1) | TWI412521B (da) |
| WO (1) | WO2007012422A1 (da) |
| ZA (1) | ZA200710952B (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007000240A1 (en) | 2005-06-28 | 2007-01-04 | Sanofi-Aventis | Isoquinoline derivatives as inhibitors of rho-kinase |
| CN101228132B (zh) | 2005-07-26 | 2012-10-10 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的环己基胺异喹啉酮衍生物 |
| DK1910333T3 (da) | 2005-07-26 | 2013-08-19 | Sanofi Sa | Piperidinylsubstituerede isoquinolonderivater som RHO-kinaseinhibitorer |
| US7893088B2 (en) * | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| CA2663193A1 (en) * | 2006-09-11 | 2008-03-20 | N.V. Organon | 2-(1-oxo-1h-isoquinolin-2-yl)acetamide derivatives |
| EP2102187B1 (en) | 2006-12-27 | 2015-04-01 | Sanofi | Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase |
| MX2009005967A (es) | 2006-12-27 | 2009-06-15 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona sustituidos con cicloalquilamina. |
| DK2132194T3 (da) | 2006-12-27 | 2011-06-27 | Sanofi Aventis | Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer |
| JP5405316B2 (ja) * | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノリン誘導体 |
| NZ577980A (en) * | 2006-12-27 | 2012-01-12 | Sanofi Aventis | Cycloalkylamine substituted isoquinolone derivatives |
| WO2008077552A1 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
| TW200845988A (en) | 2007-04-05 | 2008-12-01 | Astrazeneca Ab | New compounds and their uses 707 |
| RU2010120671A (ru) * | 2007-10-24 | 2011-11-27 | Мерк Шарп Энд Домэ Корп. (Us) | Гетероциклические фениламидные антагонисты кальциевых каналов т-типа |
| DK2313374T3 (da) * | 2008-06-24 | 2013-12-16 | Sanofi Sa | 6-substituerede isoquinoliner og isoquinolinoner |
| KR101638326B1 (ko) * | 2008-06-24 | 2016-07-12 | 사노피 | Ｒｈｏ 키나제 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 |
| AU2009262509B2 (en) * | 2008-06-24 | 2014-01-30 | Sanofi | Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors |
| EA018721B1 (ru) * | 2008-08-25 | 2013-10-30 | Айрм Ллк | Модуляторы сигнального пути hedgehog |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| BR112015017008A2 (pt) * | 2013-01-18 | 2017-07-11 | Bristol Myers Squibb Co | ftalazinonas e isoquinolinonas como inibidores de rock |
| WO2015058160A1 (en) | 2013-10-18 | 2015-04-23 | Quanticel Pharmaceuticals, Inc. | Bromodomain inhibitors |
| WO2015060373A1 (ja) | 2013-10-23 | 2015-04-30 | 中外製薬株式会社 | キナゾリノンおよびイソキノリノン誘導体 |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN105085478B (zh) * | 2014-04-28 | 2019-04-12 | 南京明德新药研发股份有限公司 | 异喹啉磺胺衍生物及其药物组合物和制药用途 |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| EP3294871A1 (en) | 2015-05-12 | 2018-03-21 | Platod | Combination of pharmacological and microfluidic features for improved platelets production |
| EP3317277B1 (en) | 2015-07-01 | 2021-01-20 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| EP3445750A4 (en) | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | THERAPEUTIC COMPOUNDS |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| MA52813A (fr) * | 2018-06-07 | 2021-04-14 | Disarm Therapeutics Inc | Inhibiteurs de sarm1 |
| CN114874236B (zh) * | 2022-06-24 | 2023-05-05 | 中国工程物理研究院化工材料研究所 | 一种五元氮杂稠环骨架及其制备方法 |
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| FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| JPH06501921A (ja) | 1990-07-31 | 1994-03-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 選択されたハロカーボンの触媒平衡化 |
| US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| IL128456A0 (en) | 1996-08-12 | 2000-01-31 | Yoshitomi Pharmaceutical | Compositions containing a Rho kinase inhibitor |
| JPH1087629A (ja) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
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