DK2132194T3 - Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer - Google Patents

Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer

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Publication number
DK2132194T3
DK2132194T3 DK07856891.2T DK07856891T DK2132194T3 DK 2132194 T3 DK2132194 T3 DK 2132194T3 DK 07856891 T DK07856891 T DK 07856891T DK 2132194 T3 DK2132194 T3 DK 2132194T3
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Prior art keywords
kinase inhibitors
rho kinase
substituted isoquinolines
isoquinolines
substituted
Prior art date
Application number
DK07856891.2T
Other languages
English (en)
Inventor
Oliver Plettenburg
Katrin Lorenz
Jochen Goerlitzer
Matthias Loehn
Original Assignee
Sanofi Aventis
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
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Publication of DK2132194T3 publication Critical patent/DK2132194T3/da

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
DK07856891.2T 2006-12-27 2007-12-19 Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer DK2132194T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06026892 2006-12-27
PCT/EP2007/011168 WO2008077555A2 (en) 2006-12-27 2007-12-19 Substituted isoquinolines and their use as rho-kinase inhibitors

Publications (1)

Publication Number Publication Date
DK2132194T3 true DK2132194T3 (da) 2011-06-27

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DK07856891.2T DK2132194T3 (da) 2006-12-27 2007-12-19 Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer

Country Status (30)

Country Link
US (1) US8772492B2 (da)
EP (1) EP2132194B1 (da)
JP (1) JP5313919B2 (da)
KR (1) KR101545533B1 (da)
CN (1) CN101573354B (da)
AR (1) AR064493A1 (da)
AT (1) ATE502027T1 (da)
AU (1) AU2007338411B2 (da)
BR (1) BRPI0720909A2 (da)
CA (1) CA2673921C (da)
CL (1) CL2007003819A1 (da)
CO (1) CO6210690A2 (da)
CR (1) CR10815A (da)
DE (1) DE602007013295D1 (da)
DK (1) DK2132194T3 (da)
EC (1) ECSP099469A (da)
ES (1) ES2363105T3 (da)
IL (1) IL199538A (da)
MA (1) MA31024B1 (da)
MX (1) MX2009005862A (da)
MY (1) MY148902A (da)
NI (1) NI200900109A (da)
NO (1) NO20092434L (da)
PT (1) PT2132194E (da)
RU (1) RU2009128690A (da)
SV (1) SV2009003316A (da)
TN (1) TN2009000273A1 (da)
TW (1) TWI448286B (da)
WO (1) WO2008077555A2 (da)
ZA (1) ZA200903554B (da)

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