CR8349A - Derivados de dihidrobenzofuranilo alcanamina y metodos para su uso - Google Patents

Derivados de dihidrobenzofuranilo alcanamina y metodos para su uso

Info

Publication number
CR8349A
CR8349A CR8349A CR8349A CR8349A CR 8349 A CR8349 A CR 8349A CR 8349 A CR8349 A CR 8349A CR 8349 A CR8349 A CR 8349A CR 8349 A CR8349 A CR 8349A
Authority
CR
Costa Rica
Prior art keywords
alcanamine
dihydrobenzofuranyl
derivatives
methods
compounds
Prior art date
Application number
CR8349A
Other languages
English (en)
Inventor
Laird Gross Jonathan
Jean Williams Marla
Paul Stack Gary
Gao Hong
Zhou Dahui
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34576747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR8349(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR8349A publication Critical patent/CR8349A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Se proporcionan compuestos de formula 1 o sales farmaceuticamente aceptables de los mismos que son agonistas o agonistas parciales de los receptores del subtipo 2c de la serotonina cerebral. Los compuestos, y composiciones que contienen los compuestos, se pueden utilizar para tratar una variedad de transtornos del sistema nervioso central tales como esquizofrenia.
CR8349A 2003-10-24 2006-04-20 Derivados de dihidrobenzofuranilo alcanamina y metodos para su uso CR8349A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51445403P 2003-10-24 2003-10-24
US10/970,714 US7435837B2 (en) 2003-10-24 2004-10-21 Dihydrobenzofuranyl alkanamine derivatives and methods for using same

Publications (1)

Publication Number Publication Date
CR8349A true CR8349A (es) 2007-06-06

Family

ID=34576747

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8349A CR8349A (es) 2003-10-24 2006-04-20 Derivados de dihidrobenzofuranilo alcanamina y metodos para su uso

Country Status (20)

Country Link
US (2) US7435837B2 (es)
EP (1) EP1675840A1 (es)
JP (1) JP2007509174A (es)
KR (1) KR20060092257A (es)
CN (1) CN1997635A (es)
AR (1) AR046309A1 (es)
AU (1) AU2004287809A1 (es)
BR (1) BRPI0415657A (es)
CA (1) CA2542878A1 (es)
CR (1) CR8349A (es)
EC (1) ECSP066520A (es)
IL (1) IL174953A0 (es)
MX (1) MXPA06004409A (es)
NO (1) NO20062139L (es)
PA (1) PA8615701A1 (es)
PE (1) PE20050482A1 (es)
RU (1) RU2006117789A (es)
TW (1) TW200526615A (es)
WO (1) WO2005044812A1 (es)
ZA (1) ZA200603233B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
CA2557271C (en) * 2004-02-26 2012-08-21 Bayer Healthcare Ag 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors
EP1730121B1 (en) * 2004-02-26 2013-08-07 Bayer Intellectual Property GmbH 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors
WO2006000902A1 (en) * 2004-06-25 2006-01-05 Pfizer Products Inc. Dihydrobenzofuran compounds and uses thereof
EP2400300A1 (en) 2004-08-25 2011-12-28 Takeda Pharmaceutical Company Limited Method of screening preventives/remedies for stress urinary incontinence
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
TW200716595A (en) * 2005-04-22 2007-05-01 Wyeth Corp Chromane and chromene derivatives and uses thereof
GT200600165A (es) * 2005-04-22 2007-03-14 Derivados dihidrobenzofuranos y usos de los mismos
CN101389325A (zh) * 2005-04-22 2009-03-18 惠氏公司 药物滥用的治疗
WO2006116171A1 (en) * 2005-04-22 2006-11-02 Wyeth Treatment of pain
MX2007013021A (es) * 2005-04-22 2008-01-11 Wyeth Corp Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c.
TW200722081A (en) * 2005-04-22 2007-06-16 Wyeth Corp New therapeutic combinations for the treatment or prevention of depression
US20060252825A1 (en) * 2005-04-22 2006-11-09 Wyeth Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
AR056980A1 (es) * 2005-04-22 2007-11-07 Wyeth Corp Derivados de dihidrobenzofurano, composiciones farmaceuticas, y uso de los mismos
AU2006239900A1 (en) * 2005-04-22 2006-11-02 Wyeth Therapeutic combinations for the treatment or prevention of psychotic disorders
GT200600167A (es) * 2005-04-22 2007-03-14 Derivados de dihidrobenzofurano y usos de los mismos
BRPI0609952A2 (pt) * 2005-04-24 2010-05-11 Wyeth Corp métodos para modular a função da bexiga
US20090203750A1 (en) * 2005-08-24 2009-08-13 Alan Kozikowski 5-HT2C Receptor Agonists as Anorectic Agents
CN101448492A (zh) * 2006-03-24 2009-06-03 惠氏公司 治疗认知障碍和其它障碍的方法
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
CL2007003043A1 (es) * 2006-10-24 2008-05-30 Wyeth Corp Compuestos derivados de cromano; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y ansiedad entre otros.
PE20081139A1 (es) * 2006-10-25 2008-09-18 Wyeth Corp Derivados de cromano, su sintesis e intermediarios
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF
UY32481A (es) * 2009-03-10 2010-09-30 Takeda Pharmaceutical Derivados de benzofurano
WO2011071136A1 (ja) 2009-12-11 2011-06-16 アステラス製薬株式会社 線維筋痛症治療剤
US8492591B2 (en) 2010-02-04 2013-07-23 The Board Of Trustees Of The University Of Illinois Highly selective 5-HT(2C) receptor agonists that show anti-psychotic effects with antagonist activity at the 5-HT(2B) receptor
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
WO2012087289A1 (en) 2010-12-21 2012-06-28 Colgate-Palmolive Company Halogenated biphenols as antibacterial agents
CN103242273B (zh) * 2012-02-09 2015-06-03 中国科学院上海药物研究所 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
ES2889876T3 (es) 2015-01-29 2022-01-14 Univ Illinois Ciclopropilmetanaminas como agonistas selectivos del receptor 5-HT(2C)
CN108084125B (zh) * 2016-11-23 2020-08-18 华东理工大学 苯并杂环烷基胺类化合物及其用途
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
EP3878447A1 (en) 2020-03-11 2021-09-15 InterAx Biotech AG Beta adrenergic receptor antagonists

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1200892A (en) 1966-10-27 1970-08-05 Ward Blenkinsop & Co Ltd Production of 2-aminomethyl-2,3-dihydrobenzofurans
US3513239A (en) 1967-03-15 1970-05-19 Smithkline Corp Pharmaceutical compositions containing 2-aminoalkyl coumaran derivatives and methods of treating depression therewith
US3826835A (en) 1971-01-08 1974-07-30 Ciba Geigy Corp 8-benzofurylmethyl-1,3,8-triazaspiro(4,5)decanes as neuroleptics
US4205080A (en) 1977-07-21 1980-05-27 Shell Oil Company 2,3-Dihydro benzofuran carboxamides
US4237144A (en) 1979-06-21 1980-12-02 Merck & Co., Inc. 2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans
GB8515388D0 (en) * 1985-06-18 1985-07-17 Ici Plc Heterocyclic compounds
US4873325A (en) 1986-06-25 1989-10-10 Uop Process for the production of amides
FR2601950B1 (fr) 1986-07-22 1988-11-10 Cerm Cent Europ Rech Mauvernay N,n-dimethyl-n'-benzoyl-n' ((2,3-dihydro) benzofuran-2-yl-methyl) 1,3-propanediamine, preparation et compositions pharmaceutiques les contenant
US4992464A (en) 1987-02-10 1991-02-12 Abbott Laboratories Heteroaryl N-hydroxy amides and ureas with polar substituents as 5-lipoxygenase inhibitors
US5171751A (en) 1989-12-04 1992-12-15 G. D. Searle & Co. Benzofuran/benzofuranalkyl-N-terminal amino hydroxy
US5147888A (en) 1989-12-04 1992-09-15 G. D. Searle & Co. N-terminal indolyy indolylalkylaminodiol β-amino acid derivatives
US5110825A (en) 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
IT1239946B (it) 1990-03-12 1993-11-27 Biomedica Foscama Industria Chimicofarmaceutica Procedimento per la sintesi degli acidi 5-acilossi e 5-alcossi-2,3-diidro-4,6,7-trimetil-2-(rs)-benzofuranacetici
US5100825A (en) * 1990-11-16 1992-03-31 Micron Technology, Inc. Method of making stacked surrounding reintrant wall capacitor
IL101785A0 (en) 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0530149A1 (de) 1991-08-30 1993-03-03 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
JP3153335B2 (ja) 1992-06-05 2001-04-09 興和株式会社 キノリン誘導体又はその塩
EP0606489A4 (en) 1992-07-03 1995-01-25 Kumiai Chemical Industry Co CONDENSED HETEROCYCLIC DERIVATIVE AND HERBICIDE.
JP3283114B2 (ja) 1992-09-07 2002-05-20 クミアイ化学工業株式会社 縮合ヘテロ環誘導体及び農園芸用殺菌剤
US5436246A (en) 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
ATE188379T1 (de) 1992-10-14 2000-01-15 Merck & Co Inc Fibrinogenrezeptor-antagonisten
US5292900A (en) 1992-12-18 1994-03-08 Abbott Laboratories O-substituted N-hydroxyurea derivatives
US5612356A (en) 1992-12-28 1997-03-18 Eisai Co., Ltd. Heterocycle-containing carbonic acid derivatives
ZA945146B (en) 1993-07-14 1995-02-24 Smithkline Beecham Corp Novel synthesis
US5852046A (en) 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
US5350748A (en) 1993-08-18 1994-09-27 Warner-Lambert Company 3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted-benzofuran-2-carboxamides as inhibitors of cell adhesion
JP2999669B2 (ja) 1993-08-24 2000-01-17 株式会社三和化学研究所 ベンゾ［ｂ］フランカルボキサミド誘導体、その製法及び用途
AU694212B2 (en) 1994-04-28 1998-07-16 Merck Sharp & Dohme Limited Benzofuran derivatives as d4 receptor antagonists
GB9408577D0 (en) 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound
WO1996001816A1 (fr) * 1994-07-07 1996-01-25 Asahi Kasei Kogyo Kabushiki Kaisha Nouveau derive de 2,3-dihydrobenzofuranne, son procede de production et son utilisation
US6150402A (en) 1994-08-15 2000-11-21 Loma Linda University Medical Center Natriuretic compounds
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
DK0707007T3 (da) 1994-10-14 2002-03-18 Merck Patent Gmbh Amino(thio)etherderivater som CNS-aktive midler
US5589482A (en) 1994-12-14 1996-12-31 Pfizer Inc. Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
EP0846109B1 (en) 1995-08-21 2002-07-24 Takeda Chemical Industries, Ltd. Quinone compound, its production and use
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
US5684041A (en) 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5955495A (en) 1996-05-03 1999-09-21 Hoffmann-La Roche Inc. Method of treating diseases of the CNS
EP0846683B1 (en) 1996-12-03 2001-09-19 F. Hoffmann-La Roche Ag 4-Hydroxy-piperidine derivatives
ATE390404T1 (de) 1997-02-27 2008-04-15 Takeda Pharmaceutical Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta
FR2772766B1 (fr) 1997-12-24 2000-06-30 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19909760B4 (de) 1998-04-17 2015-05-21 Merck Patent Gmbh Benzofuran-Derivate
US6251936B1 (en) 1998-05-12 2001-06-26 American Home Products Corporation Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia
AR019678A1 (es) 1998-06-18 2002-03-13 Novartis Ag Compuestos organicos
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
US6255324B1 (en) 1998-11-25 2001-07-03 Ned D. Heindel Amino-and mercurio-substituted 4′,5'-dihydropsoralens and therapeutical uses thereof
US6048891A (en) 1998-12-17 2000-04-11 Loma Linda University Medical Center Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease
US6410562B1 (en) 1998-12-18 2002-06-25 Eli Lilly And Company Hypoglycemic imidazoline compounds
EP1149085A1 (en) * 1999-01-27 2001-10-31 Eli Lilly And Company Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists
DE60014936T2 (de) 1999-08-20 2005-10-13 Takeda Chemical Industries, Ltd. Trizyklische dihydrobenzofurane, verfahren zu deren herstellung und mittel
DE10044091A1 (de) 2000-09-07 2002-04-04 Merck Patent Gmbh Chromanonderivate
EP1377549A1 (en) 2001-03-12 2004-01-07 Millennium Pharmaceuticals, Inc. Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
US20020183309A1 (en) 2001-03-16 2002-12-05 Cowart Marlon D. Novel amines as histamine-3 receptor ligands and their therapeutic applications
US20020177589A1 (en) 2001-03-16 2002-11-28 Cowart Marlon D. Novel amines as histamine-3 receptor ligands and their therapeutic applications
US6969730B2 (en) 2001-03-16 2005-11-29 Abbott Laboratories Amines as histamine-3 receptor ligands and their therapeutic applications
JPWO2002100833A1 (ja) 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
EP1444224B1 (en) 2001-08-14 2006-05-03 Eli Lilly And Company 3-substituted oxindole beta-3 agonists
US6569894B1 (en) 2001-10-04 2003-05-27 Bristol-Myers Squibb Company Arylalkylbenzofuran derivatives as melatonergic agents
EP1432696A1 (en) 2001-10-04 2004-06-30 Wyeth Chroman derivatives as 5-hydroxytryptamine-6 ligands
WO2003029239A1 (en) 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
US6667322B2 (en) 2001-10-05 2003-12-23 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
US20030105830A1 (en) 2001-12-03 2003-06-05 Duc Pham Scalable network media access controller and methods
US20030134835A1 (en) 2002-01-11 2003-07-17 Arthur Hancock Histamine-3 receptor ligands for diabetes conditions
US20050113283A1 (en) 2002-01-18 2005-05-26 David Solow-Cordero Methods of treating conditions associated with an EDG-4 receptor
US6653346B1 (en) 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
DE10205274A1 (de) 2002-02-08 2003-08-21 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen
EP1348708A1 (en) 2002-02-28 2003-10-01 Sanofi-Synthelabo Heteroaryl substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
CN1646118A (zh) * 2002-03-29 2005-07-27 中外制药株式会社 预防或治疗呼吸系统疾病的药物组合物
KR20030084444A (ko) 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US20040009976A1 (en) 2002-04-30 2004-01-15 Kumiko Takeuchi Hypoglycemic imidazoline compounds
SI2389937T1 (sl) 2002-06-14 2018-10-30 Toyama Chemical Co., Ltd, Farmacevtska sestava za izboljšanje možganske funkcije
AU2003291012A1 (en) 2002-11-15 2004-06-15 Galileo Pharmaceuticals, Inc. Chroman derivatives for the reduction of inflammation symptoms
TW200418825A (en) 2002-12-16 2004-10-01 Hoffmann La Roche Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives
WO2005011670A1 (en) 2003-08-01 2005-02-10 Chugai Seiyaku Kabushiki Kaisha Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors
WO2005037223A2 (en) 2003-10-15 2005-04-28 Brigham And Women's Hospital, Inc. Methods and compositions for immunomodulation
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7728155B2 (en) 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
US20050137234A1 (en) 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
US20050137247A1 (en) 2003-12-22 2005-06-23 The Brigham And Women's Hospital, Inc. Methods and compositions for treatment of hypertension
US7288553B2 (en) 2004-05-03 2007-10-30 Janssen Pharmaceutica N.V. Indole derivatives as selective androgen receptor modulator (SARMS)
EP1600447A1 (en) 2004-05-28 2005-11-30 Neuropharma S.A.U. Butyrylcholinesterase selective inhibitors
EP1776106B1 (en) 2004-06-22 2013-08-07 Vertex Pharmaceuticals Incorporated Heterocyclic derivatives for modulation of calcium channels
GT200500296A (es) 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
GT200500297A (es) 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
TW200716595A (en) 2005-04-22 2007-05-01 Wyeth Corp Chromane and chromene derivatives and uses thereof
GT200600159A (es) 2005-04-22 2007-03-14 Derivados benzodioxano y benzodioxolano y usos de los mismos
WO2006116171A1 (en) 2005-04-22 2006-11-02 Wyeth Treatment of pain
GT200600165A (es) 2005-04-22 2007-03-14 Derivados dihidrobenzofuranos y usos de los mismos
TW200722081A (en) 2005-04-22 2007-06-16 Wyeth Corp New therapeutic combinations for the treatment or prevention of depression
AR056980A1 (es) 2005-04-22 2007-11-07 Wyeth Corp Derivados de dihidrobenzofurano, composiciones farmaceuticas, y uso de los mismos
AU2006239900A1 (en) 2005-04-22 2006-11-02 Wyeth Therapeutic combinations for the treatment or prevention of psychotic disorders
CN101389325A (zh) 2005-04-22 2009-03-18 惠氏公司 药物滥用的治疗
US20060252825A1 (en) 2005-04-22 2006-11-09 Wyeth Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
GT200600167A (es) 2005-04-22 2007-03-14 Derivados de dihidrobenzofurano y usos de los mismos
MX2007013021A (es) 2005-04-22 2008-01-11 Wyeth Corp Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c.
BRPI0609952A2 (pt) 2005-04-24 2010-05-11 Wyeth Corp métodos para modular a função da bexiga

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CA2542878A1 (en) 2005-05-19
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KR20060092257A (ko) 2006-08-22
BRPI0415657A (pt) 2006-12-19
US7435837B2 (en) 2008-10-14
EP1675840A1 (en) 2006-07-05
AU2004287809A1 (en) 2005-05-19
PA8615701A1 (es) 2005-11-25
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US20090082434A1 (en) 2009-03-26
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MXPA06004409A (es) 2007-01-26
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