CL2008001158A1 - Compuestos derivados de (piperidin-4-il)-([1,3,4]tiadiazol-2-il)-amina o (piperidin-4-il)-(tiazol-2-il)-amina, antagonistas del receptor de dopamina d2; composiciones farmaceuticas que los contienen; y su uso en la prevencion y tratamiento de enfermedades del snc tales como la esquizofrenia. - Google Patents
Compuestos derivados de (piperidin-4-il)-([1,3,4]tiadiazol-2-il)-amina o (piperidin-4-il)-(tiazol-2-il)-amina, antagonistas del receptor de dopamina d2; composiciones farmaceuticas que los contienen; y su uso en la prevencion y tratamiento de enfermedades del snc tales como la esquizofrenia.Info
- Publication number
- CL2008001158A1 CL2008001158A1 CL2008001158A CL2008001158A CL2008001158A1 CL 2008001158 A1 CL2008001158 A1 CL 2008001158A1 CL 2008001158 A CL2008001158 A CL 2008001158A CL 2008001158 A CL2008001158 A CL 2008001158A CL 2008001158 A1 CL2008001158 A1 CL 2008001158A1
- Authority
- CL
- Chile
- Prior art keywords
- piperidin
- amine
- schizophrenia
- treatment
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de tiadiazoles, antagonistas del receptor de dopamina 2 de disociación rápida; composición farmacéutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de trastornos del sistema nervioso central, como esquizofrenia, trastorno psicótico, trastorno bipolar, trastorno de pánico, dependencia de sustancias, entre otras.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07106706 | 2007-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008001158A1 true CL2008001158A1 (es) | 2008-11-03 |
Family
ID=38476031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008001158A CL2008001158A1 (es) | 2007-04-23 | 2008-04-22 | Compuestos derivados de (piperidin-4-il)-([1,3,4]tiadiazol-2-il)-amina o (piperidin-4-il)-(tiazol-2-il)-amina, antagonistas del receptor de dopamina d2; composiciones farmaceuticas que los contienen; y su uso en la prevencion y tratamiento de enfermedades del snc tales como la esquizofrenia. |
Country Status (15)
Country | Link |
---|---|
US (1) | US8933101B2 (es) |
EP (1) | EP2148879B1 (es) |
JP (1) | JP5431306B2 (es) |
KR (1) | KR101506156B1 (es) |
CN (1) | CN101663299A (es) |
AR (1) | AR066242A1 (es) |
AU (1) | AU2008240729B2 (es) |
CA (1) | CA2682671C (es) |
CL (1) | CL2008001158A1 (es) |
ES (1) | ES2400710T3 (es) |
IL (1) | IL201661A (es) |
MX (1) | MX2009011416A (es) |
RU (1) | RU2489431C2 (es) |
TW (1) | TWI423969B (es) |
WO (1) | WO2008128996A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
AU2008240727C1 (en) * | 2007-04-23 | 2013-10-03 | Janssen Pharmaceutica N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
CN101663292A (zh) * | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离的多巴胺2受体拮抗剂的4-烷氧基哒嗪衍生物 |
CN102159554B (zh) * | 2008-07-03 | 2014-09-24 | 詹森药业有限公司 | 作为5-ht6受体拮抗剂的取代的6-(1-哌嗪基)-哒嗪 |
LT2307374T (lt) * | 2008-07-31 | 2017-04-25 | Janssen Pharmaceutica Nv | Piperazin-1-il-trifluormetil-pakeistieji piridinai kaip greitai disocijuojantys dopamino 2 receptoriaus antagonistai |
CN107690429B (zh) * | 2015-04-07 | 2022-02-25 | Ela制药有限公司 | 用于治疗和/或预防细胞或组织坏死的组合物,其特异性靶向组织蛋白酶c和/或cela1和/或cela3a和/或与其结构相关的酶 |
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JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
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CN101506165B (zh) | 2006-08-15 | 2012-07-04 | 霍夫曼-拉罗奇有限公司 | 苯基、吡啶和喹啉衍生物 |
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TW200829566A (en) | 2006-12-08 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
CN101663292A (zh) * | 2007-04-23 | 2010-03-03 | 詹森药业有限公司 | 作为快速解离的多巴胺2受体拮抗剂的4-烷氧基哒嗪衍生物 |
AU2008240727C1 (en) * | 2007-04-23 | 2013-10-03 | Janssen Pharmaceutica N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
AR068480A1 (es) * | 2007-09-20 | 2009-11-18 | Glaxo Group Ltd | Compuesto de 4-heteroaril-piperidinil-n-substituido su uso para la preparacion de un medicamento util para el tratamiento de una afeccion en el que seria beneficioso el agonismo de un receptor muscarinico m1 y composicion farmaceutica que lo comprende |
CN102159554B (zh) * | 2008-07-03 | 2014-09-24 | 詹森药业有限公司 | 作为5-ht6受体拮抗剂的取代的6-(1-哌嗪基)-哒嗪 |
LT2307374T (lt) * | 2008-07-31 | 2017-04-25 | Janssen Pharmaceutica Nv | Piperazin-1-il-trifluormetil-pakeistieji piridinai kaip greitai disocijuojantys dopamino 2 receptoriaus antagonistai |
-
2008
- 2008-04-18 CA CA2682671A patent/CA2682671C/en active Active
- 2008-04-18 CN CN200880013094A patent/CN101663299A/zh active Pending
- 2008-04-18 WO PCT/EP2008/054732 patent/WO2008128996A1/en active Application Filing
- 2008-04-18 MX MX2009011416A patent/MX2009011416A/es active IP Right Grant
- 2008-04-18 ES ES08749605T patent/ES2400710T3/es active Active
- 2008-04-18 KR KR1020097022765A patent/KR101506156B1/ko active IP Right Grant
- 2008-04-18 AU AU2008240729A patent/AU2008240729B2/en not_active Ceased
- 2008-04-18 RU RU2009142981/04A patent/RU2489431C2/ru active
- 2008-04-18 EP EP08749605A patent/EP2148879B1/en active Active
- 2008-04-18 US US12/597,164 patent/US8933101B2/en active Active
- 2008-04-18 JP JP2010504648A patent/JP5431306B2/ja active Active
- 2008-04-22 CL CL2008001158A patent/CL2008001158A1/es unknown
- 2008-04-22 AR ARP080101682A patent/AR066242A1/es not_active Application Discontinuation
- 2008-04-22 TW TW097114580A patent/TWI423969B/zh not_active IP Right Cessation
-
2009
- 2009-10-21 IL IL201661A patent/IL201661A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
IL201661A0 (en) | 2010-05-31 |
AU2008240729A1 (en) | 2008-10-30 |
KR101506156B1 (ko) | 2015-03-26 |
IL201661A (en) | 2015-07-30 |
JP2010525015A (ja) | 2010-07-22 |
US8933101B2 (en) | 2015-01-13 |
CN101663299A (zh) | 2010-03-03 |
JP5431306B2 (ja) | 2014-03-05 |
ES2400710T3 (es) | 2013-04-11 |
TW200911799A (en) | 2009-03-16 |
TWI423969B (zh) | 2014-01-21 |
EP2148879A1 (en) | 2010-02-03 |
RU2009142981A (ru) | 2011-05-27 |
AR066242A1 (es) | 2009-08-05 |
RU2489431C2 (ru) | 2013-08-10 |
EP2148879B1 (en) | 2012-11-28 |
AU2008240729B2 (en) | 2012-08-23 |
CA2682671C (en) | 2015-11-17 |
US20100120860A1 (en) | 2010-05-13 |
WO2008128996A1 (en) | 2008-10-30 |
MX2009011416A (es) | 2009-11-05 |
KR20100016090A (ko) | 2010-02-12 |
CA2682671A1 (en) | 2008-10-30 |
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CL2008003787A1 (es) | Compuestos derivados de heteroarilo, antagonistas del receptor de orexina; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos del sueno, trastornos psiquiatricos, neurologicos, ansiedad, depresion, esquizofrenia, alzheimer, parkinson, entre otras. | |
CL2008001158A1 (es) | Compuestos derivados de (piperidin-4-il)-([1,3,4]tiadiazol-2-il)-amina o (piperidin-4-il)-(tiazol-2-il)-amina, antagonistas del receptor de dopamina d2; composiciones farmaceuticas que los contienen; y su uso en la prevencion y tratamiento de enfermedades del snc tales como la esquizofrenia. | |
CR10020A (es) | Antagonistas de los receptores 2 de dopamina de rapida disociación | |
DOP2009000133A (es) | Derivados de indol como agonistas de los receptores s1p1 | |
CL2007000396A1 (es) | Compuestos derivados de benzoil-piperidina, moduladores del receptor 5ht2/d3; composicion farmaceutica que los comprende;y su uso en el tratamiento y/o prevencion de patologias delsnc, tales como psicosis, esquizofrenia, depresion, ansiedad,adiccion a drogas y problemas cognitivos. | |
ECSP066520A (es) | Derivados de dihidrobenzofuranilo alcanamina y métodos para su uso | |
CL2008002864A1 (es) | Compuestos derivados de 2-amino-quinolina, antagonistas del receptor de serotonina 5-ht 5a; procedimiento de preparacion;composicion farmaceutica; y uso de los compuestos en la prevencion o el tratamiento de depresion,trastornos de ansiedad,esquizofrenia,trastornos de panico,trastornos de memoria,demencia,entre otros. | |
CL2007001555A1 (es) | Compuestos derivados de 4-amino-pirido[3,2-e]pirazinas; inhibidores de fosfodiesterasa 10 (pde10); procedimeinto de preparacion; composicion framaceutica; combinacion farmaceutica, y sus uso en el tratamiento de trastornos neurologicos y psiquiatricos, tales como esquizofrenia y otros trastornos psicoticos. | |
GT200600159A (es) | Derivados benzodioxano y benzodioxolano y usos de los mismos | |
CL2007003261A1 (es) | Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, tales como esquizofrenia, | |
CL2008000836A1 (es) | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. | |
AR054347A1 (es) | Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion | |
GT200700024A (es) | Derivados de amina | |
CR8472A (es) | Indoles,1h- indazoles,1,2- benzisoxazoles y 1,2 benzisotiazoles,y preparacion y usos de los mismos | |
AR056103A1 (es) | Compuestos de(piran-piperidinil)benzimidazol, composiciones farmaceuticas que los comprenden, proceso de preparacion y usos en el tratamiento de afecciones mediadas por agonistas del receptor muscarinico m1 | |
GT200600161A (es) | Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de los trastornos psicoticos | |
CL2008002808A1 (es) | Compuestos derivados de benzoxazol, agonistas del receptor muscarinico m1; composicion farmaceutica que comprende a dichos compuestos; y uso para el tratamiento de esquizofrenia, alteraciones cognitivas o enfermedad de alzheimer. | |
CL2008002689A1 (es) | Compuestos derivados de heterociclo 1,4 piperidina sustituida; compuestos intermediarios; composicion farmaceutica; proceso de preparacion; y su uso en el tratamiento del alzheimer y esquizofrenia. | |
CL2008002162A1 (es) | Compuestos derivados de 3-benzoisoxazol-piperidin; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento y/o prevencion de trastornos cognitivos, adiccion a drogas, depresion, ansiedad, entre otras. | |
CL2007002899A1 (es) | Compuestos derivados de azaciclilaminas n-sustituidas, inhibidores del receptor de histamina 3; proceso de preparacion; composicion farmaceutica que comprende los compuestos, y usopara el tratamiento de trastornos cognitivos, esquizofre nia y enfermedad de alzheimer entre otros. | |
BRPI0415769A (pt) | alcanaminas de diidrobenzofuranila e composições farmacêuticas contendo-as | |
CL2008000440A1 (es) | Compuestos derivados de 4-aril-3-piridazina, antagonistas del receptor de dopamina 2 de rapida disociacion; composicion farmaceutica que comprende a dichos compuestos; y su uso como antipsicotico para el tratamiento o prevencion de la esquizofrenia, | |
CL2008000904A1 (es) | Compuestos derivados de azabiciclo [3.3.0]octenos y azabiciclo[3.3.1]nonanos sustituidos, con la alta afinidad a receptores nicotinicos de subtipo alfa4beta2 en el sistema nervioso central; composicion farmaceutica; y su uso en el tratamiento del deterioro de la memorias asociado a la edad, deterioro cognitivo leve, demencia senil, entre otras. | |
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