JP2010535252A5 - - Google Patents

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JP2010535252A5
JP2010535252A5 JP2010520219A JP2010520219A JP2010535252A5 JP 2010535252 A5 JP2010535252 A5 JP 2010535252A5 JP 2010520219 A JP2010520219 A JP 2010520219A JP 2010520219 A JP2010520219 A JP 2010520219A JP 2010535252 A5 JP2010535252 A5 JP 2010535252A5
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compound
diabetes
type
metabolic
nachr agonist
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JP2010520219A
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Priority claimed from PCT/US2008/071893 external-priority patent/WO2009018511A2/en
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Claims (31)

  1. 選択的α7 nAChRアゴニストを含む、代謝障害を治療または予防するための薬剤。
  2. 選択的α7 nAChRアゴニストを含む、薬剤誘発性中枢神経系障害を治療または予防するための薬剤。
  3. α7 nAChRアゴニストが化合物A：
    Figure 2010535252
     、
    化合物B：
    Figure 2010535252
     もしくは
    化合物C：
    Figure 2010535252
     、
    またはそれらの製薬上許容可能な塩である、請求項1または2に記載の薬剤。
  4. α7 nAChRアゴニストが化合物Cまたはその製薬上許容可能な塩である、請求項3に記載の薬剤。
  5. 代謝障害がI型糖尿病、II型糖尿病、メタボリック症候群、アテローム性動脈硬化、肥満および高血糖のうちの1つまたは複数である、請求項1、3または4に記載の薬剤。
  6. 高血糖がスタチン治療の結果である、請求項5に記載の薬剤。
  7. 薬剤誘発性中枢神経系障害がスタチン治療の結果である、請求項2に記載の薬剤。
  8. 式：
    Figure 2010535252
     の化合物またはその製薬上許容可能な塩を含む、代謝障害を治療または予防するための薬剤。
  9. 代謝障害がI型糖尿病、II型糖尿病、メタボリック症候群、アテローム性動脈硬化、肥満および高血糖のうちの1つまたは複数である、請求項8に記載の薬剤。
  10. 日用量が約0.001mg/kg〜約3.0mg/kgである、請求項8または9に記載の薬剤。
  11. 代謝障害を治療または予防するための薬剤の製造における選択的α7 nAChRアゴニストの使用。
  12. 薬剤誘発性中枢神経系障害を治療または予防するための薬剤の製造における選択的α7 nAChRアゴニストの使用。
  13. α7 nAChRアゴニストが化合物A：
    Figure 2010535252
     、
    化合物B：
    Figure 2010535252
     、もしくは
    化合物C：
    Figure 2010535252
     、
    またはそれらの製薬上許容可能な塩である、請求項11または12に記載の使用。
  14. α7 nAChRアゴニストが化合物Cまたはその製薬上許容可能な塩である、請求項13に記載の使用。
  15. 代謝障害がI型糖尿病、II型糖尿病、メタボリック症候群、アテローム性動脈硬化、肥満および高血糖のうちの1つまたは複数である、請求項11、13または14に記載の使用。
  16. 高血糖がスタチン治療の結果である、請求項15に記載の使用。
  17. 薬剤誘発性中枢神経系障害がスタチン治療の結果である、請求項12に記載の使用。
  18. 代謝障害を治療または予防するための薬剤の製造における化合物C：
    Figure 2010535252
    またはその製薬上許容可能な塩の使用。
  19. 代謝障害がI型糖尿病、II型糖尿病、メタボリック症候群、アテローム性動脈硬化、肥満および高血糖のうちの1つまたは複数である、請求項18に記載の使用。
  20. 日用量が約0.001mg/kg〜約3.0mg/kgである、請求項18または19に記載の使用。
  21. 代謝障害の治療または予防で使用するための選択的α7 nAChRアゴニスト化合物。
  22. 薬剤誘発性中枢神経系障害の治療または予防で使用するための選択的α7 nAChRアゴニスト化合物。
  23. α7 nAChRアゴニストが化合物A：
    Figure 2010535252
     、
    化合物B：
    Figure 2010535252
     、もしくは
    化合物C：
    Figure 2010535252
     、
    またはそれらの製薬上許容可能な塩である、請求項21または22に記載の化合物。
  24. α7 nAChRアゴニストが化合物Cまたはその製薬上許容可能な塩である、請求項23に記載の化合物。
  25. 代謝障害がI型糖尿病、II型糖尿病、メタボリック症候群、アテローム性動脈硬化、肥満および高血糖のうちの1つまたは複数である、請求項21、23または24に記載の化合物。
  26. 高血糖がスタチン治療の結果である、請求項25に記載の化合物。
  27. 薬剤誘発性中枢神経系障害がスタチン治療の結果である、請求項22に記載の化合物。
  28. 代謝障害の治療または予防で使用するための選択的α7 nAChRアゴニスト化合物：
    Figure 2010535252
     またはその製薬上許容可能な塩。
  29. 代謝障害がI型糖尿病、II型糖尿病、メタボリック症候群、アテローム性動脈硬化、肥満および高血糖のうちの1つまたは複数である、請求項28に記載の化合物。
  30. 日用量が約0.001mg/kg〜約3.0mg/kgである、請求項28または29に記載の化合物。
  31. 式：
    Figure 2010535252
     の化合物またはその製薬上許容可能な塩。
JP2010520219A 2007-08-02 2008-08-01 代謝障害を治療または予防するためのα７ｎＡＣｈＲアゴニスト Pending JP2010535252A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95361307P 2007-08-02 2007-08-02
US95361007P 2007-08-02 2007-08-02
US95361407P 2007-08-02 2007-08-02
US97165407P 2007-09-12 2007-09-12
PCT/US2008/071893 WO2009018511A2 (en) 2007-08-02 2008-08-01 Alpha7 nachr agonists for treating or preventing metabolic disorders

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JP2010535252A JP2010535252A (ja) 2010-11-18
JP2010535252A5 true JP2010535252A5 (ja) 2011-01-06

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JP2010520219A Pending JP2010535252A (ja) 2007-08-02 2008-08-01 代謝障害を治療または予防するためのα７ｎＡＣｈＲアゴニスト
JP2013148087A Active JP5852611B2 (ja) 2007-08-02 2013-07-17 （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法
JP2013148091A Active JP6106549B2 (ja) 2007-08-02 2013-07-17 （２ｓ，３ｒ）−ｎ−（２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）ベンゾフラン−２−カルボキサミド、その新規塩形態およびその使用方法

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US (6) US20110124678A1 (ja)
EP (6) EP2185152A2 (ja)
JP (4) JP5358573B2 (ja)
KR (2) KR20100063043A (ja)
CN (4) CN101784273B (ja)
AR (1) AR067775A1 (ja)
AU (3) AU2008283813A1 (ja)
BR (2) BRPI0814889A2 (ja)
CA (2) CA2694510A1 (ja)
CL (3) CL2008002271A1 (ja)
CO (2) CO6260080A2 (ja)
CY (1) CY1113561T1 (ja)
DK (2) DK2182949T3 (ja)
EC (2) ECSP10010007A (ja)
ES (3) ES2606752T3 (ja)
HK (1) HK1140968A1 (ja)
HR (1) HRP20130286T1 (ja)
HU (1) HUE030387T2 (ja)
IL (1) IL218976A0 (ja)
ME (1) ME01508B (ja)
MX (3) MX2010001293A (ja)
MY (1) MY148002A (ja)
NO (2) NO20100077L (ja)
NZ (2) NZ582828A (ja)
PE (3) PE20121821A1 (ja)
PL (1) PL2182949T3 (ja)
PT (1) PT2182949E (ja)
RS (1) RS52743B (ja)
RU (2) RU2012140148A (ja)
SA (2) SA08290475B1 (ja)
SI (1) SI2182949T1 (ja)
TW (3) TW201402116A (ja)
UY (1) UY31265A (ja)
WO (2) WO2009018505A1 (ja)
ZA (1) ZA201000719B (ja)

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