JP2007504174A5 - - Google Patents
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- Publication number
- JP2007504174A5 JP2007504174A5 JP2006525016A JP2006525016A JP2007504174A5 JP 2007504174 A5 JP2007504174 A5 JP 2007504174A5 JP 2006525016 A JP2006525016 A JP 2006525016A JP 2006525016 A JP2006525016 A JP 2006525016A JP 2007504174 A5 JP2007504174 A5 JP 2007504174A5
- Authority
- JP
- Japan
- Prior art keywords
- disorders
- epilepsy
- pharmaceutical composition
- pain
- depression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010015037 Epilepsy Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010057666 Anxiety disease Diseases 0.000 claims 2
- 208000008787 Cardiovascular Disease Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 206010012601 Diabetes mellitus Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010039911 Seizure Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000001079 digestive Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
Claims (2)
- 発作、疼痛、不安障害、抑うつ、耽溺、消化器疾患、尿生殖器の障害、循環器疾患、てんかん、糖尿病、又は癌の治療に使用するための医薬組成物であって、当該組成物は医薬的に許容し得る賦形剤との混合物で、投与用量の少なくとも一つの請求項１の化合物を含む医薬組成物。
- 発作、疼痛、不安障害、抑うつ、耽溺、消化器疾患、尿生殖器の障害、循環器疾患、てんかん、糖尿病、又は癌を治療するための薬剤の製造における、請求項１の少なくとも一つの化合物又はその医薬組成物の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/655,393 US7186726B2 (en) | 1998-06-30 | 2003-09-03 | Preferentially substituted calcium channel blockers |
| PCT/CA2004/001629 WO2005021523A1 (en) | 2003-09-03 | 2004-09-03 | Piperazine substituted compounds used as calcium channel blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007504174A JP2007504174A (ja) | 2007-03-01 |
| JP2007504174A5 true JP2007504174A5 (ja) | 2007-10-18 |
Family
ID=34273458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525016A Pending JP2007504174A (ja) | 2003-09-03 | 2004-09-03 | カルシウムチャネル遮断薬として使用されるピペラジン置換化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7186726B2 (ja) |
| EP (1) | EP1670775A4 (ja) |
| JP (1) | JP2007504174A (ja) |
| CN (1) | CN1871225A (ja) |
| AU (1) | AU2004268711A1 (ja) |
| BR (1) | BRPI0414094A (ja) |
| CA (1) | CA2537487A1 (ja) |
| IL (1) | IL174025A0 (ja) |
| MX (1) | MXPA06002467A (ja) |
| NZ (1) | NZ546254A (ja) |
| WO (1) | WO2005021523A1 (ja) |
| ZA (1) | ZA200602684B (ja) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040266784A1 (en) * | 1998-06-30 | 2004-12-30 | Snutch Terrance P. | Calcium channel inhibitors comprising benzhydril spaced from piperazine |
| US20040259866A1 (en) * | 1998-06-30 | 2004-12-23 | Snutch Terrance P. | Calcium channel blockers comprising two benzhydril moieties |
| US6951862B2 (en) * | 1998-06-30 | 2005-10-04 | Neuromed Technologies, Inc. | Calcium channel blockers comprising two benzhydril moieties |
| US7186726B2 (en) * | 1998-06-30 | 2007-03-06 | Neuromed Pharmaceuticals Ltd. | Preferentially substituted calcium channel blockers |
| US20060084660A1 (en) * | 1998-06-30 | 2006-04-20 | Neuromed Technologies Inc. | Calcium channel blockers comprising two benzhydril moieties |
| US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| BRPI0509715A (pt) * | 2004-04-09 | 2007-09-18 | Neuromed Pharmaceuticals Ltd | derivados de diarilamina como canais bloqueadores de cálcio |
| GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| EP1784401A4 (en) * | 2004-08-30 | 2009-07-15 | Neuromed Pharmaceuticals Ltd | UREA DERIVATIVES AS CALCIUM CHANNEL BLOCKERS |
| US7511077B2 (en) * | 2005-02-09 | 2009-03-31 | Neuromed Pharmaceuticals Ltd. | Diamine calcium channel blockers |
| EP1871372A4 (en) * | 2005-04-08 | 2010-06-02 | Neuromed Pharmaceuticals Ltd | COMBINATION THERAPY WHICH INCLUDES AN AGENT BLOCKING CALCIUM CHANNELS OF TYPE N FOR THE RELIEF OF PAIN |
| WO2006124865A2 (en) * | 2005-05-19 | 2006-11-23 | Vertex Pharmaceuticals Incorporated | Biaryls derivatives useful as modulators of ion channels |
| EP1904491A2 (en) | 2005-05-31 | 2008-04-02 | Vertex Pharmaceuticals Incorporated | Heterocycles useful as modulators of ion channels |
| EP1976841A4 (en) * | 2005-12-19 | 2010-07-28 | Neuromed Pharmaceuticals Ltd | HETEROCYCLIC AMIDDERIVES AS CALCIUM CHANNEL BLOCKERS |
| WO2007118323A1 (en) * | 2006-04-17 | 2007-10-25 | Neuromed Pharmaceuticals Ltd. | Isoxazole derivatives as calcium channel blockers |
| WO2007133481A2 (en) * | 2006-05-11 | 2007-11-22 | Neuromed Pharmaceuticals Ltd. | Method for increasing the bioavailability of benzhydryl piperazine containing compounds |
| US20100029681A1 (en) * | 2006-05-26 | 2010-02-04 | Hassan Pajouhesh | Heterocyclic compounds as calcium channel blockers |
| CA2663280A1 (en) * | 2006-09-14 | 2008-03-20 | Neuromed Pharmaceuticals Ltd. | Diaryl piperidine compounds as calcium channel blockers |
| EP2074105A4 (en) * | 2006-10-13 | 2010-10-06 | Neuromed Pharmaceuticals Ltd | CYCLOPROPYL-PIPERAZINE COMPOUNDS AS CALCIUM INHIBITORS |
| TWI404716B (zh) * | 2006-10-17 | 2013-08-11 | Kudos Pharm Ltd | 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物 |
| WO2008050200A1 (en) * | 2006-10-24 | 2008-05-02 | Pfizer Products Inc. | Oxadiazole compounds as calcium channel antagonists |
| US20080139578A1 (en) * | 2006-11-30 | 2008-06-12 | Catherine Abbadie | Substituted piperizines for the treatment of pain |
| GB0700893D0 (en) | 2007-01-17 | 2007-02-21 | King S College London | Male contraceptive |
| US8263607B2 (en) | 2007-05-22 | 2012-09-11 | Astellas Pharma Inc. | 1-substituted tetrahydroisoquinoline compound |
| MX2010004028A (es) * | 2007-10-17 | 2010-04-30 | Kudos Pharm Ltd | 4-[3-(4-ciclopropancarbonil-piperacin-1-carbonil)-4-fluoro-bencil ]-2h-ftalacin-1-ona. |
| CA2722706A1 (en) * | 2008-04-28 | 2009-11-05 | Zalicus Pharmaceuticals Ltd. | Di-t-butylphenyl piperazines as calcium channel blockers |
| WO2009132452A1 (en) * | 2008-04-28 | 2009-11-05 | Neuromed Pharmaceuticals Ltd. | Diaryl-cyclylalkyl derivatives as calcium channel blockers |
| HUE030800T2 (en) * | 2008-10-07 | 2017-05-29 | Astrazeneca Uk Ltd | Pharmaceutical Form No. 514 |
| PT3002008T (pt) | 2010-03-11 | 2018-12-24 | Univ New York | Compostos de amido como moduladores roryt e suas utilizações |
| US8409560B2 (en) | 2011-03-08 | 2013-04-02 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
| WO2012122279A1 (en) | 2011-03-08 | 2012-09-13 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
| BR112014005268A2 (pt) | 2011-09-09 | 2017-03-28 | Univ New York | compostos de amido como moduladores de ror t e usos dos mesmos |
| CN103130745B (zh) * | 2011-11-28 | 2017-03-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 二芳基哌嗪类化合物及其医药用途 |
| CN105218501A (zh) * | 2014-07-03 | 2016-01-06 | 南京大学 | 含哌嗪环的香豆素类衍生物及其制备与在抗菌药物中的应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB920416A (en) | 1958-04-04 | 1963-03-06 | Lakeside Lab Inc | Piperazino compounds |
| GB1051527A (ja) * | 1964-07-31 | |||
| BG17385A1 (ja) | 1971-11-09 | 1973-11-10 | ||
| US3997539A (en) | 1974-05-31 | 1976-12-14 | American Hoechst Corporation | 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and processes for the preparation thereof |
| US4188485A (en) * | 1978-06-16 | 1980-02-12 | G. D. Searle & Co. | 1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds |
| ES8304135A3 (es) | 1981-07-06 | 1983-01-01 | Ferrer Int | Procedimiento de obtencion de benzhidrilpiperazinas |
| ES514167A0 (es) | 1982-07-20 | 1983-04-01 | Ferrer Int | "procedimiento de obtencion de benzhidrilpiperazinas". |
| JPS61155358A (ja) | 1984-12-21 | 1986-07-15 | Suntory Ltd | ジアリール酪酸誘導体 |
| FR2584723B1 (fr) | 1985-07-09 | 1988-02-12 | Adir | Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| DE3600390A1 (de) * | 1986-01-09 | 1987-07-16 | Hoechst Ag | Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel |
| US5386025A (en) * | 1990-02-20 | 1995-01-31 | The Salk Institute Biotechnology/Industrial Associates | Calcium channel compositions and methods |
| IE73232B1 (en) | 1990-05-25 | 1997-05-21 | Akzo Nv | Isochromane derivatives |
| US5703071A (en) * | 1990-08-29 | 1997-12-30 | Pharmacia & Upjohn Company | Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases |
| TW205034B (ja) * | 1990-09-13 | 1993-05-01 | Pola Kasei Kogyo Kk | |
| ES2024991A6 (es) * | 1990-12-27 | 1992-03-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de piperazinilcarboxamidas. |
| ES2027897A6 (es) | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la difenilmetilpiperacina. |
| DE4111861A1 (de) * | 1991-04-11 | 1992-10-15 | Schwabe Willmar Gmbh & Co | Benzopyranone, verfahren zu ihrer herstellung und verwendung |
| JPH08504792A (ja) | 1992-12-22 | 1996-05-21 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | カルシウムチャンネルアンタゴニストとしてのピペリジン誘導体 |
| JP3204424B2 (ja) * | 1993-02-18 | 2001-09-04 | 三菱化学フォームプラスティック株式会社 | ポリプロピレン系樹脂発泡粒子 |
| CN1100774C (zh) * | 1993-12-08 | 2003-02-05 | 阿尔康实验室公司 | 具有高效钙拮抗物和抗氧化剂活性的化合物及其用作细胞保护剂 |
| IT1270993B (it) * | 1994-03-18 | 1997-05-26 | Recordati Chem Pharm | Derivati chinzolilamminici attivi come alfa-antagonisti |
| US5623051A (en) * | 1994-11-10 | 1997-04-22 | University Of Washington | Methods and compositions for screening for presynaptic calcium channel blockers |
| GB9526560D0 (en) | 1995-12-27 | 1996-02-28 | Bayer Ag | Use of 2-Amino-Heterocycles |
| JPH10135749A (ja) * | 1996-10-29 | 1998-05-22 | Nec Corp | 高周波帯増幅器 |
| US5866574A (en) | 1997-04-10 | 1999-02-02 | Kyowa Hakko Kogyo Co., Ltd. | Pancreatitis remedy |
| IT1293804B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Diarilalchilpiperazine attive sulle basse vie urinarie |
| WO1999015129A2 (en) | 1997-09-23 | 1999-04-01 | Bristol-Myers Squibb Company | SELECTIVE cPLA2 INHIBITORS |
| WO1999025686A1 (en) | 1997-11-18 | 1999-05-27 | Teijin Limited | Cyclic amine derivatives and their use as drugs |
| AU3459999A (en) | 1998-04-27 | 1999-11-16 | Warner-Lambert Company | Substituted diarylalkyl amides as calcium channel antagonists |
| US6387897B1 (en) * | 1998-06-30 | 2002-05-14 | Neuromed Technologies, Inc. | Preferentially substituted calcium channel blockers |
| US7186726B2 (en) | 1998-06-30 | 2007-03-06 | Neuromed Pharmaceuticals Ltd. | Preferentially substituted calcium channel blockers |
| US6011035A (en) * | 1998-06-30 | 2000-01-04 | Neuromed Technologies Inc. | Calcium channel blockers |
| US6310059B1 (en) | 1998-06-30 | 2001-10-30 | Neuromed Technologies, Inc. | Fused ring calcium channel blockers |
| US6943168B2 (en) * | 1998-06-30 | 2005-09-13 | Neuromed Technologies Inc. | Calcium channel inhibitors comprising benzhydril spaced from piperazine |
| US6951862B2 (en) * | 1998-06-30 | 2005-10-04 | Neuromed Technologies, Inc. | Calcium channel blockers comprising two benzhydril moieties |
| US6492375B2 (en) * | 1998-06-30 | 2002-12-10 | Neuromed Technologies, Inc. | Partially saturated calcium channel blockers |
| US6268377B1 (en) | 1998-09-28 | 2001-07-31 | Merck & Co., Inc. | Method for treating androgen-related conditions |
| US6267945B1 (en) | 1998-12-18 | 2001-07-31 | Neuromed Technologies, Inc. | Farnesol-related calcium channel blockers |
| CA2439730A1 (en) * | 2000-12-27 | 2002-07-11 | Nobuyuki Kawakatsu | Benzofuran derivatives and pharmaceutical compositions containing the same |
| GB0203299D0 (en) | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel compounds |
| ATE473005T1 (de) | 2002-03-13 | 2010-07-15 | Janssen Pharmaceutica Nv | Histone-deacetylase-inhibitoren |
-
2003
- 2003-09-03 US US10/655,393 patent/US7186726B2/en not_active Expired - Fee Related
-
2004
- 2004-09-03 BR BRPI0414094-0A patent/BRPI0414094A/pt not_active IP Right Cessation
- 2004-09-03 AU AU2004268711A patent/AU2004268711A1/en not_active Abandoned
- 2004-09-03 EP EP04761792A patent/EP1670775A4/en not_active Withdrawn
- 2004-09-03 WO PCT/CA2004/001629 patent/WO2005021523A1/en active Search and Examination
- 2004-09-03 CA CA002537487A patent/CA2537487A1/en not_active Abandoned
- 2004-09-03 NZ NZ546254A patent/NZ546254A/en unknown
- 2004-09-03 CN CNA2004800288244A patent/CN1871225A/zh active Pending
- 2004-09-03 JP JP2006525016A patent/JP2007504174A/ja active Pending
- 2004-09-03 MX MXPA06002467A patent/MXPA06002467A/es not_active Application Discontinuation
-
2006
- 2006-03-01 IL IL174025A patent/IL174025A0/en unknown
- 2006-03-31 ZA ZA200602684A patent/ZA200602684B/en unknown
- 2006-11-16 US US11/601,005 patent/US7666865B2/en not_active Expired - Fee Related
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