JP2010535219A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010535219A5 JP2010535219A5 JP2010519951A JP2010519951A JP2010535219A5 JP 2010535219 A5 JP2010535219 A5 JP 2010535219A5 JP 2010519951 A JP2010519951 A JP 2010519951A JP 2010519951 A JP2010519951 A JP 2010519951A JP 2010535219 A5 JP2010535219 A5 JP 2010535219A5
- Authority
- JP
- Japan
- Prior art keywords
- loxl2
- fibrosis
- patient
- antigen
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101001043352 Homo sapiens Lysyl oxidase homolog 2 Proteins 0.000 claims 13
- 102100021948 Lysyl oxidase homolog 2 Human genes 0.000 claims 13
- 239000003112 inhibitor Substances 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 9
- 230000036963 noncompetitive effect Effects 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 206010016654 Fibrosis Diseases 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 230000007705 epithelial mesenchymal transition Effects 0.000 claims 5
- 230000004761 fibrosis Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 230000004614 tumor growth Effects 0.000 claims 4
- 206010027476 Metastases Diseases 0.000 claims 3
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 claims 3
- 102100026858 Protein-lysine 6-oxidase Human genes 0.000 claims 3
- 206010064390 Tumour invasion Diseases 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 230000009400 cancer invasion Effects 0.000 claims 3
- 230000009401 metastasis Effects 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010039580 Scar Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
- 201000002793 renal fibrosis Diseases 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 108010074051 C-Reactive Protein Proteins 0.000 claims 1
- 102100032752 C-reactive protein Human genes 0.000 claims 1
- 206010048768 Dermatosis Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 206010019668 Hepatic fibrosis Diseases 0.000 claims 1
- 208000002260 Keloid Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 208000011379 keloid formation Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000013074 reference sample Substances 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96328207P | 2007-08-02 | 2007-08-02 | |
| US96321407P | 2007-08-02 | 2007-08-02 | |
| US96324907P | 2007-08-02 | 2007-08-02 | |
| US96324607P | 2007-08-02 | 2007-08-02 | |
| US96324807P | 2007-08-02 | 2007-08-02 | |
| US60/963,214 | 2007-08-02 | ||
| US60/963,249 | 2007-08-02 | ||
| US60/963,246 | 2007-08-02 | ||
| US60/963,248 | 2007-08-02 | ||
| US60/963,282 | 2007-08-02 | ||
| PCT/US2008/009354 WO2009017833A2 (en) | 2007-08-02 | 2008-08-01 | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014117893A Division JP5851555B2 (ja) | 2007-08-02 | 2014-06-06 | 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535219A JP2010535219A (ja) | 2010-11-18 |
| JP2010535219A5 true JP2010535219A5 (enExample) | 2011-09-15 |
| JP5659014B2 JP5659014B2 (ja) | 2015-01-28 |
Family
ID=40094743
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519263A Expired - Fee Related JP5312459B2 (ja) | 2007-08-02 | 2008-08-01 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
| JP2010519951A Active JP5659014B2 (ja) | 2007-08-02 | 2008-08-01 | 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物 |
| JP2013116416A Expired - Fee Related JP5770219B2 (ja) | 2007-08-02 | 2013-05-31 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
| JP2014117893A Active JP5851555B2 (ja) | 2007-08-02 | 2014-06-06 | 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物 |
| JP2015125989A Pending JP2015212281A (ja) | 2007-08-02 | 2015-06-23 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
| JP2015235400A Pending JP2016094428A (ja) | 2007-08-02 | 2015-12-02 | 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物 |
| JP2017095079A Expired - Fee Related JP6357264B2 (ja) | 2007-08-02 | 2017-05-11 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
| JP2018114560A Pending JP2018172398A (ja) | 2007-08-02 | 2018-06-15 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519263A Expired - Fee Related JP5312459B2 (ja) | 2007-08-02 | 2008-08-01 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013116416A Expired - Fee Related JP5770219B2 (ja) | 2007-08-02 | 2013-05-31 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
| JP2014117893A Active JP5851555B2 (ja) | 2007-08-02 | 2014-06-06 | 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物 |
| JP2015125989A Pending JP2015212281A (ja) | 2007-08-02 | 2015-06-23 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
| JP2015235400A Pending JP2016094428A (ja) | 2007-08-02 | 2015-12-02 | 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物 |
| JP2017095079A Expired - Fee Related JP6357264B2 (ja) | 2007-08-02 | 2017-05-11 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
| JP2018114560A Pending JP2018172398A (ja) | 2007-08-02 | 2018-06-15 | Loxおよびloxl2阻害剤ならびにこれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (10) | US8679485B2 (enExample) |
| EP (4) | EP2537529B1 (enExample) |
| JP (8) | JP5312459B2 (enExample) |
| CN (6) | CN105330743B (enExample) |
| AU (4) | AU2008282739B2 (enExample) |
| CA (2) | CA2693310C (enExample) |
| CY (2) | CY1113897T1 (enExample) |
| DK (2) | DK2185198T3 (enExample) |
| ES (3) | ES2534490T3 (enExample) |
| HR (2) | HRP20150208T1 (enExample) |
| HU (1) | HUE025283T2 (enExample) |
| PL (2) | PL2185198T3 (enExample) |
| PT (3) | PT2537529T (enExample) |
| SI (2) | SI2182981T1 (enExample) |
| WO (2) | WO2009035791A1 (enExample) |
Families Citing this family (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2896693B2 (ja) | 1990-05-15 | 1999-05-31 | 高田重工株式会社 | 橋桁材の歪矯正装置 |
| US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| GB0604647D0 (en) | 2006-03-08 | 2006-04-19 | Shchepinov Mikhail | Stabilized food supplements and their derivatives |
| CA2693310C (en) * | 2007-08-02 | 2018-11-27 | Arresto Biosciences, Inc. | Lox and loxl2 inhibitors, antibodies and uses thereof |
| WO2009114809A1 (en) * | 2008-03-14 | 2009-09-17 | Retrotope, Inc. | Therapies for cancer using isotopically substituted lysine |
| US9107935B2 (en) | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
| SG173598A1 (en) * | 2009-02-06 | 2011-09-29 | Arresto Biosciences Inc | Methods and compositions for treatment of neovascularization |
| WO2010099364A2 (en) * | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
| CN102803965A (zh) | 2009-05-05 | 2012-11-28 | 耶达研究与发展有限公司 | 用于识别个人心血管疾病的发生的装置和方法 |
| WO2011022670A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| WO2011022667A2 (en) | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | Catalytic domains from lysyl oxidase and loxl2 |
| WO2011022709A1 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vitro screening assays |
| CN102711821A (zh) * | 2009-08-21 | 2012-10-03 | 吉联亚生物科技有限公司 | 治疗方法和组合物 |
| BR112012008111A2 (pt) * | 2009-08-21 | 2017-02-21 | Gilead Biologics Inc | métodos e composições para tratamento de desordens fibróticas pulmonares |
| CN102597775A (zh) | 2009-09-25 | 2012-07-18 | 佐马技术有限公司 | 筛选方法 |
| EP2482814A4 (en) * | 2009-09-29 | 2013-04-03 | Gilead Biologics Inc | METHOD AND COMPOSITIONS FOR TREATING OKULAR FIBROSIS |
| JP5934102B2 (ja) | 2009-10-30 | 2016-06-15 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | Pufa誘導体による酸化ストレス障害の緩和 |
| EP2528619B1 (en) | 2010-01-26 | 2013-12-04 | Centre Leon Berard | Screening method for identifying compounds which block tumour growth by inducing irreversible senescence in tumour cells |
| AU2014215963B2 (en) * | 2010-02-04 | 2016-04-14 | Gilead Biologics, Inc | Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor |
| MX2012009088A (es) * | 2010-02-04 | 2012-12-05 | Gilead Biologics Inc | Anticuerpos que se enlazan a lisil oxidasa-tipo2 (loxl2) y metodos de uso para los mismos. |
| US20120329061A1 (en) * | 2010-03-11 | 2012-12-27 | Board Of Regents, The University Of Texas System | Quantitative rt-pcr detection for genes involved in epithelial mesenchymal transition in peripheral blood of cancer patients |
| WO2011132085A2 (en) * | 2010-04-21 | 2011-10-27 | Kalluri, Raghu | Methods and compositions for treating fibrosis |
| CN105148269A (zh) | 2011-02-21 | 2015-12-16 | 菲布他丁有限合伙公司 | 治疗和诊断疾病的方法 |
| WO2012139045A1 (en) | 2011-04-08 | 2012-10-11 | Gilead Biologics, Inc. | Methods and compositions for normalization of tumor vasculature by inhibition of loxl2 |
| WO2012148926A2 (en) | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating pufas |
| CA2834342C (en) | 2011-04-26 | 2021-08-31 | Retrotope, Inc. | Impaired energy processing disorders and mitochondrial deficiency |
| KR102110175B1 (ko) | 2011-04-26 | 2020-05-13 | 레트로토프 인코포레이티드 | Pufa 산화와 관련된 장애 |
| AU2012249921B2 (en) | 2011-04-26 | 2017-06-08 | Biojiva Llc | Oxidative retinal diseases |
| WO2012155071A1 (en) | 2011-05-12 | 2012-11-15 | Gilead Biologics, Inc. | Methods of identifying lysyl oxidase - like - 2 (loxl2) binding partners |
| JP2014523521A (ja) * | 2011-06-01 | 2014-09-11 | ギリアード バイオロジックス, インコーポレイテッド | リシルオキシダーゼ様2のアッセイおよびその使用の方法 |
| FR2976587B1 (fr) | 2011-06-20 | 2015-04-03 | Basf Beauty Care Solutions F | Methode de dosage in vitro par technique immunologique |
| SG10201607331WA (en) * | 2011-09-30 | 2016-11-29 | Somalogic Inc | Cardiovascular risk event prediction and uses thereof |
| CN102397544A (zh) * | 2011-11-25 | 2012-04-04 | 百泰生物药业有限公司 | 一种单克隆抗体用于治疗非小细胞肺癌的用途 |
| EP2819697A4 (en) | 2012-02-29 | 2016-03-09 | Gilead Biologics Inc | ANTIBODIES AGAINST METALLOPROTEINASE 9 OF MATRIX |
| US10107778B2 (en) | 2012-09-28 | 2018-10-23 | Case Western Reserve University | System and method for detecting lysyl oxidase-like 2 protein (LOXL2) and breast cancer |
| JP2016500700A (ja) * | 2012-10-30 | 2016-01-14 | ギリアード サイエンシーズ, インコーポレイテッド | リシルオキシダーゼ様2(loxl2)に関する治療および診断方法 |
| WO2014152122A2 (en) * | 2013-03-15 | 2014-09-25 | Children's Medical Center Corporation | Methods of altering vascular permeability and uses thereof |
| MX371412B (es) * | 2013-05-23 | 2020-01-29 | Shire Human Genetic Therapies | ANTICUERPOS BIESPECÍFICOS QUE SE UNEN ESPECÍFICAMENTE A LOXL2 Y ccl.2, COMPOSICIONES DE LOS MISMOS, Y SU USO EN EL TRATAMIENTO DE ESCLERODERMIA. |
| US10570204B2 (en) | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
| AU2014354769A1 (en) | 2013-11-26 | 2016-05-26 | Gilead Sciences, Inc. | Therapies for treating myeloproliferative disorders |
| JP2017503001A (ja) | 2014-01-20 | 2017-01-26 | ギリアード サイエンシーズ, インコーポレイテッド | がんを処置するための療法 |
| US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US20150342943A1 (en) * | 2014-06-03 | 2015-12-03 | Gilead Sciences, Inc. | Methods of treating liver disease |
| CN106456772A (zh) * | 2014-06-11 | 2017-02-22 | 吉利德科学公司 | 用于治疗心血管疾病的方法 |
| US10040868B2 (en) | 2014-07-24 | 2018-08-07 | Yeda Research And Development Co. Ltd. | Antibodies targeted against LOXL-2 for the treatment of collagen-associated pathologies |
| EP2990480A1 (en) * | 2014-08-29 | 2016-03-02 | Christian-Albrechts-Universität zu Kiel | Anti-LOXL4 antibodies and derivatives there |
| EP3229837B1 (en) | 2014-12-08 | 2025-02-05 | Dana-Farber Cancer Institute, Inc. | Methods for upregulating immune responses using combinations of anti-rgmb and anti-pd-1 agents |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| TW201639573A (zh) | 2015-02-03 | 2016-11-16 | 吉李德科學股份有限公司 | 有關治療癌症之合併治療 |
| WO2016133059A1 (ja) * | 2015-02-16 | 2016-08-25 | 株式会社ファーマフーズ | Fstl1を利用した抗がん剤・転移抑制剤およびその併用剤 |
| PL3321265T3 (pl) | 2015-03-04 | 2020-11-16 | Gilead Sciences, Inc. | Związki 4,6-diamino-pirydo[3,2-d]pirymidynowe i ich wykorzystanie jako modulatorów receptorów toll-podobnych |
| JP6800872B2 (ja) | 2015-03-06 | 2020-12-16 | ファーマケア,インク. | リシルオキシダーゼ様2阻害剤とその使用 |
| CN107592861B (zh) | 2015-03-06 | 2021-06-08 | 法玛克亚公司 | 氟化赖氨酰氧化酶样2抑制剂及其用途 |
| CN106442956A (zh) * | 2015-08-11 | 2017-02-22 | 钱朝南 | 一种筛选抗肿瘤转移的化合物的方法 |
| CA2998875C (en) | 2015-09-17 | 2023-08-29 | Ohio State Innovation Foundation | Carborane compounds and methods of use thereof |
| ES2900482T3 (es) | 2015-10-01 | 2022-03-17 | Gilead Sciences Inc | Combinación de un inhibidor de Btk y un inhibidor de punto de control para el tratamiento del cáncer |
| EP3362074B1 (en) | 2015-10-16 | 2023-08-09 | President and Fellows of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
| EP3380452B1 (en) | 2015-11-23 | 2021-03-24 | Retrotope, Inc. | Site-specific isotopic labeling of 1, 4-diene systems |
| WO2017106556A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Tank-binding kinase inhibitor compounds |
| JP7094219B2 (ja) * | 2016-02-03 | 2022-07-01 | ノルディック バイオサイエンス エイ/エス | 線維症の組み合わせたバイオマーカー測定 |
| EA037302B9 (ru) * | 2016-02-12 | 2021-04-09 | Фармаксис Лтд. | Ингибиторы лизилоксидаз, представляющие собой индольные и азаиндольные производные галогеналлиламина, и их применения |
| GB201602934D0 (en) | 2016-02-19 | 2016-04-06 | Cancer Res Inst Royal | Compounds |
| JP2019510752A (ja) | 2016-03-04 | 2019-04-18 | ギリアード サイエンシーズ, インコーポレイテッド | オートタキシン阻害剤の組成物及び合剤 |
| JP2019512271A (ja) | 2016-03-21 | 2019-05-16 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | T細胞疲弊状態特異的遺伝子発現調節因子およびその使用 |
| ES2863700T3 (es) * | 2016-03-22 | 2021-10-11 | Mayo Found Medical Education & Res | Uso de inhibidores de ácido graso sintasa para tratar la fibrosis |
| CA3019003A1 (en) | 2016-04-08 | 2017-10-12 | Gilead Sciences, Inc. | Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases |
| WO2017181790A1 (zh) * | 2016-04-19 | 2017-10-26 | 南京中硼联康医疗科技有限公司 | 用于消除β淀粉样蛋白沉积斑块的中子捕获治疗系统 |
| WO2017197088A1 (en) * | 2016-05-12 | 2017-11-16 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors for the treatment of inflammatory conditions |
| MY190771A (en) | 2016-06-13 | 2022-05-12 | I Mab Biopharma Us Ltd | Anti-pd-l1 antibodies and uses thereof |
| MA45848A (fr) | 2016-08-04 | 2019-06-12 | Gilead Sciences Inc | Cobicistat destiné à être utilisé dans des traitements du cancer |
| EP3507288B1 (en) | 2016-09-02 | 2020-08-26 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| CA3035346A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| WO2018048930A1 (en) * | 2016-09-07 | 2018-03-15 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
| MA46204A (fr) | 2016-09-07 | 2021-03-17 | Pharmakea Inc | Formes cristallines d'un inhibiteur de lysyl oxydase de type 2 et leurs procédés de fabrication |
| BR112019004513A2 (pt) | 2016-09-07 | 2019-06-18 | Pharmakea Inc | usos de um inibidor de lisil oxidase-like 2 |
| US20180133212A1 (en) | 2016-11-03 | 2018-05-17 | Gilead Sciences, Inc. | Combination of a bcl-2 inhibitor and a bromodomain inhibitor for treating cancer |
| CN106492218A (zh) * | 2016-11-08 | 2017-03-15 | 清华大学 | 氨基丙腈在制备药物中的用途 |
| WO2018097977A1 (en) | 2016-11-22 | 2018-05-31 | Gilead Sciences, Inc. | Crystalline forms of a phosphate complex of a bet inhibitor |
| JP7206193B2 (ja) | 2017-01-24 | 2023-01-17 | アイ-エムエービー バイオファーマ ユーエス リミテッド | 抗cd73抗体およびその使用 |
| DE102017000896A1 (de) * | 2017-02-01 | 2018-08-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Selektives Freisetzungssystem für Tumortherapeutika und Tumordiagnostika sowie Biosensor für Tumorgewebe |
| AU2018224136B2 (en) | 2017-02-24 | 2021-10-21 | Gilead Sciences, Inc. | Inhibitors of Bruton's Tyrosine Kinase |
| WO2018156901A1 (en) | 2017-02-24 | 2018-08-30 | Gilead Sciences, Inc. | Inhibitors of bruton's tyrosine kinase |
| WO2018170488A1 (en) | 2017-03-17 | 2018-09-20 | Gilead Sciences, Inc. | Method of purifying an antibody |
| CN118750586A (zh) | 2017-04-06 | 2024-10-11 | 莎思坦控股有限责任公司 | 基于胶原的药物组合物和装置和生产方法及其用途 |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| JP7098748B2 (ja) | 2017-12-20 | 2022-07-11 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. | Stingアダプタータンパク質を活性化するホスホン酸結合を有する2’3’環状ジヌクレオチド |
| CN111566120B (zh) | 2017-12-20 | 2023-09-29 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸 |
| EP3737364A1 (en) * | 2018-01-11 | 2020-11-18 | Emphysema Solutions BV | Compositions and methods for the treatment of lung emphysema and other forms of copd |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| EP3781556B1 (en) | 2018-04-19 | 2025-06-18 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| WO2019217780A1 (en) | 2018-05-11 | 2019-11-14 | Phosphorex, Inc. | Microparticles and nanoparticles having negative surface charges |
| WO2019222112A1 (en) | 2018-05-14 | 2019-11-21 | Gilead Sciences, Inc. | Mcl-1 inhibitors |
| CN118221646A (zh) | 2018-07-13 | 2024-06-21 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| MX2021001347A (es) | 2018-08-03 | 2021-04-13 | Pharmaxis Ltd | Inhibidores derivados de haloalilamina sulfona de lisil oxidasas y sus usos. |
| WO2020072656A1 (en) | 2018-10-03 | 2020-04-09 | Gilead Sciences, Inc. | Imidozopyrimidine derivatives |
| KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| US11071730B2 (en) | 2018-10-31 | 2021-07-27 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| WO2020101571A1 (en) * | 2018-11-12 | 2020-05-22 | Agency For Science, Technology And Research | Methods for manipulating cell state transitions in cancer |
| AU2019393785A1 (en) * | 2018-12-03 | 2021-06-17 | Ohio State Innovation Foundation | Carborane compounds, carborane analogs, and methods of use thereof |
| US12410366B2 (en) * | 2019-02-22 | 2025-09-09 | Konica Minolta, Inc. | Infrared-emitting compound, and luminescent thin film, luminescent particle, wavelength conversion film and infrared-emitting surface light source containing same |
| EP3705893A1 (en) * | 2019-03-05 | 2020-09-09 | Humanitas Mirasole S.p.A. | Methods to assess the risk of being affected by prostate cancer |
| US12318403B2 (en) | 2019-03-07 | 2025-06-03 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′-cyclic dinucleotides and prodrugs thereof |
| US20220143061A1 (en) | 2019-03-07 | 2022-05-12 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| KR20220031946A (ko) | 2019-04-22 | 2022-03-14 | 서스테인 홀딩스, 엘엘씨 | 콜라겐 펩타이드-기초 약제 조성물 및 이를 제조하고 사용하기 위한 장치 및 방법 |
| WO2020237025A1 (en) | 2019-05-23 | 2020-11-26 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| WO2020255038A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| FI20195550A1 (en) * | 2019-06-20 | 2020-12-21 | Kemira Oyj | Risk level assessment in an aqueous process |
| US11446303B2 (en) * | 2019-06-21 | 2022-09-20 | Tosk, Inc. | Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions |
| NZ783169A (en) | 2019-06-25 | 2024-12-20 | Gilead Sciences Inc | Flt3l-fc fusion proteins and methods of use |
| US11697807B2 (en) | 2019-09-30 | 2023-07-11 | Case Western Reserve University | Electrochemical biosensor |
| KR20210044589A (ko) * | 2019-10-15 | 2021-04-23 | 재단법인 한국파스퇴르연구소 | 2-메톡시에스트라디올 유도체 및 이들의 의약 용도 |
| CN111118142A (zh) * | 2020-01-17 | 2020-05-08 | 上海市同济医院 | 血清赖氨酸氧化酶作为肾间质纤维化的分层诊断性生物标志物 |
| TWI832035B (zh) | 2020-02-14 | 2024-02-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| US12409206B2 (en) * | 2020-02-19 | 2025-09-09 | Hepion Pharmaceuticals, Inc. | Use of cyclosporine analogues for treating fibrosis |
| US11779910B2 (en) | 2020-02-21 | 2023-10-10 | Biojiva Llc | Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof |
| EP4173639A4 (en) | 2020-06-26 | 2024-03-13 | RaQualia Pharma Inc. | Method for selecting cancer patient for which combination therapy of retinoid and cancer treatment agent will be effective, and combined drug of retinoid and cancer treatment agent |
| GB202019109D0 (en) * | 2020-12-03 | 2021-01-20 | Novai Ltd | Marker for use in identifying or predicting angiogenesis |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| US20220389394A1 (en) | 2021-05-18 | 2022-12-08 | Gilead Sciences, Inc. | METHODS OF USING FLT3L-Fc FUSION PROTEINS |
| CN113321743B (zh) * | 2021-07-02 | 2022-10-21 | 海南精准医疗科技有限公司 | 一种靶向赖氨酰氧化酶1的嵌合抗原受体及其用途 |
| KR20240091056A (ko) | 2021-10-28 | 2024-06-21 | 길리애드 사이언시즈, 인코포레이티드 | 피리디진-3(2h)-온 유도체 |
| WO2023077030A1 (en) | 2021-10-29 | 2023-05-04 | Gilead Sciences, Inc. | Cd73 compounds |
| JP2024545193A (ja) | 2021-12-22 | 2024-12-05 | ギリアード サイエンシーズ, インコーポレイテッド | Ikarosジンクフィンガーファミリー分解剤及びその使用 |
| EP4452414A2 (en) | 2021-12-22 | 2024-10-30 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Parp7抑制劑 |
| US12358887B2 (en) | 2022-03-17 | 2025-07-15 | Gilead Sciences, Inc. | IKAROS Zinc Finger Family degraders and uses thereof |
| US12233056B2 (en) | 2022-04-06 | 2025-02-25 | Syntara Limited | Lysyl oxidase inhibitors for treating myeloid malignancies |
| CN119487038A (zh) | 2022-04-21 | 2025-02-18 | 吉利德科学公司 | Kras g12d调节化合物 |
| WO2023239764A1 (en) * | 2022-06-08 | 2023-12-14 | Ohio State Innovation Foundation | Methods and compositions for treating lupus |
| WO2024006929A1 (en) | 2022-07-01 | 2024-01-04 | Gilead Sciences, Inc. | Cd73 compounds |
| CN116064765B (zh) * | 2022-08-02 | 2023-09-05 | 首都医科大学附属北京友谊医院 | 检测loxl1基因突变的物质在制备肝纤维化患者分子分型的产品中的应用 |
| AU2023357892A1 (en) * | 2022-10-07 | 2025-05-22 | Nanoegg Research Laboratories, Inc. | Method for detecting inflammatory skin disease and judging severity thereof |
| EP4638436A1 (en) | 2022-12-22 | 2025-10-29 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| WO2024215754A1 (en) | 2023-04-11 | 2024-10-17 | Gilead Sciences, Inc. | Kras modulating compounds |
| CN121079300A (zh) | 2023-04-21 | 2025-12-05 | 吉利德科学公司 | Prmt5抑制剂及其用途 |
| US20250042922A1 (en) | 2023-06-30 | 2025-02-06 | Gilead Sciences, Inc. | Kras modulating compounds |
| CN116794308A (zh) * | 2023-07-20 | 2023-09-22 | 中国药科大学 | β-1,4-半乳糖基转移酶1及其抑制剂在制备治疗急慢性肝病药物中的应用 |
| US20250066328A1 (en) | 2023-07-26 | 2025-02-27 | Gilead Sciences, Inc. | Parp7 inhibitors |
| WO2025024811A1 (en) | 2023-07-26 | 2025-01-30 | Gilead Sciences, Inc. | Parp7 inhibitors |
| WO2025054530A1 (en) | 2023-09-08 | 2025-03-13 | Gilead Sciences, Inc. | Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds |
| WO2025054347A1 (en) | 2023-09-08 | 2025-03-13 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20250154172A1 (en) | 2023-11-03 | 2025-05-15 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| WO2025245003A1 (en) | 2024-05-21 | 2025-11-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| CN120518770B (zh) * | 2025-05-21 | 2025-12-09 | 北京大学人民医院 | 一种抗loxl2纳米抗体或抗原结合片段与应用 |
| CN120425051A (zh) * | 2025-07-09 | 2025-08-05 | 吉林大学 | Angpt2作为生物标志物在嗜铬细胞瘤和副神经节瘤分子分型及预后评估中的应用 |
| CN120600339B (zh) * | 2025-08-05 | 2025-09-30 | 中国人民解放军空军军医大学 | 一种抗真菌药物肝毒性检测方法及系统 |
Family Cites Families (244)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7002A (en) * | 1850-01-08 | Obe-washek | ||
| NL154600B (nl) * | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) * | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) * | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) * | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) * | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) * | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) * | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) * | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) * | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| JPS5913521B2 (ja) | 1975-06-19 | 1984-03-30 | メイトウサンギヨウ カブシキガイシヤ | 磁性酸化鉄・デキストラン複合体の製造法 |
| US3984533A (en) * | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| US4098876A (en) * | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| EP0046742B1 (en) * | 1980-08-25 | 1984-06-27 | KabiVitrum AB | Peptide substrates for determination of protease activity |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| DE3278334D1 (en) | 1981-10-23 | 1988-05-19 | Genetics Int Inc | Sensor for components of a liquid mixture |
| US4485088A (en) | 1982-03-26 | 1984-11-27 | Bio-Products, Inc. | Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4454106A (en) | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
| US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5011771A (en) * | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) * | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| PT81498B (pt) | 1984-11-23 | 1987-12-30 | Schering Ag | Processo para a preparacao de composicoes para diagnostico contendo particulas magneticas |
| ATE45735T1 (de) | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4627445A (en) | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
| US4801531A (en) * | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US4916193A (en) | 1987-12-17 | 1990-04-10 | Allied-Signal Inc. | Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5021404A (en) | 1988-04-20 | 1991-06-04 | The Children's Medical Center Corporation | Angiostatic collagen modulators |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5092877A (en) | 1988-09-01 | 1992-03-03 | Corvita Corporation | Radially expandable endoprosthesis |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5120764A (en) * | 1988-11-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| CA2006008C (en) | 1988-12-20 | 2000-02-15 | Donald J. Kessler | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| US4994071A (en) | 1989-05-22 | 1991-02-19 | Cordis Corporation | Bifurcating stent apparatus and method |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU641673B2 (en) | 1989-06-29 | 1993-09-30 | Medarex, Inc. | Bispecific reagents for aids therapy |
| US5262035A (en) | 1989-08-02 | 1993-11-16 | E. Heller And Company | Enzyme electrodes |
| US4997854A (en) * | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
| US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5163952A (en) | 1990-09-14 | 1992-11-17 | Michael Froix | Expandable polymeric stent with memory and delivery apparatus and method |
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| US5641484A (en) * | 1990-12-04 | 1997-06-24 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen |
| EP1046421B8 (en) | 1990-12-06 | 2006-01-11 | Affymetrix, Inc. (a Delaware Corporation) | Methods and reagents for very large scale immobilized polymer synthesis |
| AT397134B (de) * | 1991-02-19 | 1994-02-25 | Hoerbiger Ventilwerke Ag | Ventil |
| US20020123476A1 (en) * | 1991-03-19 | 2002-09-05 | Emanuele R. Martin | Therapeutic delivery compositions and methods of use thereof |
| US6933286B2 (en) * | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
| JPH06507398A (ja) | 1991-05-14 | 1994-08-25 | リプリジェン コーポレーション | Hiv感染治療のための異種複合抗体 |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5661133B1 (en) * | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
| EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
| US6235887B1 (en) * | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| EP0552108B1 (en) | 1992-01-17 | 1999-11-10 | Lakowicz, Joseph R. | Energy transfer phase-modulation fluoro-immunoassay |
| US5281521A (en) * | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US6015562A (en) * | 1992-09-22 | 2000-01-18 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
| US5721138A (en) * | 1992-12-15 | 1998-02-24 | Sandford University | Apolipoprotein(A) promoter and regulatory sequence constructs and methods of use |
| FI92882C (fi) | 1992-12-29 | 1995-01-10 | Medix Biochemica Ab Oy | Kertakäyttöinen testiliuska ja menetelmä sen valmistamiseksi |
| US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
| US5646185A (en) | 1993-10-14 | 1997-07-08 | The Board Of Trustees Of The Leland Stanford Junior University | Tumor treatment method |
| US5674693A (en) | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
| US5700695A (en) | 1994-06-30 | 1997-12-23 | Zia Yassinzadeh | Sample collection and manipulation method |
| US5908635A (en) | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
| US5807718A (en) * | 1994-12-02 | 1998-09-15 | The Scripps Research Institute | Enzymatic DNA molecules |
| US6096716A (en) | 1994-12-12 | 2000-08-01 | The Board Of Regents, The University Of Texas System | Liposome-mediated transfection of central nervous system cells |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5935860A (en) | 1995-03-07 | 1999-08-10 | The George Washington University | Use of uteroglobin expression as a molecular marker for prostatic intraepithelial neoplasia |
| US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
| WO1996040746A1 (en) | 1995-06-07 | 1996-12-19 | Trustees Of Boston University | Lysyloxidase inhibitors |
| AUPN363995A0 (en) | 1995-06-19 | 1995-07-13 | Memtec Limited | Electrochemical cell |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| AU724579B2 (en) * | 1996-04-01 | 2000-09-28 | Sankyo Company Limited | Anti-Fas recombinant antibodies and DNA therefor |
| AUPO156596A0 (en) | 1996-08-09 | 1996-09-05 | University Of Sydney, The | Synthetic polynucleotides |
| US6489093B1 (en) | 1996-09-20 | 2002-12-03 | President And Fellows Of Harvard College | Combinatorial approach for generating novel coordination complexes |
| US5958703A (en) | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
| EP0958495B1 (en) * | 1997-02-06 | 2002-11-13 | Therasense, Inc. | Small volume in vitro analyte sensor |
| WO1998041656A1 (en) * | 1997-03-19 | 1998-09-24 | The Board Of Trustees Of The University Of Arkansas | Compositions and method for the early diagnosis of ovarian cancer |
| PT996460E (pt) * | 1997-08-08 | 2005-04-29 | Univ California | Tratamento da fibrose renal com anticorpos contra integrina alfa-v-beta 6 |
| US6277622B1 (en) * | 1997-08-11 | 2001-08-21 | The University Of Sydney | Synthetic polynucleotides |
| US6225118B1 (en) * | 1997-10-01 | 2001-05-01 | Biocure Limited | Multicellular in vitro assay of angiogenesis |
| EP1029048A2 (en) * | 1997-11-05 | 2000-08-23 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
| US6140056A (en) * | 1999-01-27 | 2000-10-31 | Millennium Pharmaceuticals, Inc. | MSP-18 protein and nucleic acid molecules and uses therefor |
| US20020072089A1 (en) | 1999-11-23 | 2002-06-13 | Holtzman Douglas A. | Novel ITALY, Lor-2, STRIFE, TRASH, BDSF, LRSG, and STMST protein and nucleic acid molecules and uses therefor |
| US6300092B1 (en) | 1999-01-27 | 2001-10-09 | Millennium Pharmaceuticals Inc. | Methods of use of a novel lysyl oxidase-related protein |
| EP1062340A2 (en) * | 1998-03-13 | 2000-12-27 | The Baylor College of Medicine | Compositions and methods for the treatment and prevention of metastatic disorders |
| WO1999065928A2 (en) | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues |
| US6228538B1 (en) * | 1998-08-28 | 2001-05-08 | Micron Technology, Inc. | Mask forming methods and field emission display emitter mask forming methods |
| US20040058355A1 (en) | 1998-09-30 | 2004-03-25 | Millennium Pharmaceuticals, Inc. | Novel 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, H1983, M1983, 38555 or 593 molecules and uses therefor |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US7108982B1 (en) | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
| US20030149997A1 (en) | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
| KR100746522B1 (ko) * | 1999-04-22 | 2007-08-07 | 바이오겐 아이덱 엠에이 인코포레이티드 | 인테그린 알파-4 서브유닛의 길항 물질을 사용하는섬유증의 치료 방법 |
| US20030152926A1 (en) | 1999-08-11 | 2003-08-14 | Eos Biotechnology, Inc. | Novel methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
| GB0001309D0 (en) * | 2000-01-20 | 2000-03-08 | Nestle Sa | Valve arrangement |
| US6808707B2 (en) | 2000-02-04 | 2004-10-26 | Matrix Design | Wound healing compositions and methods using tropoelastin and lysyl oxidase |
| AU2001255320A1 (en) | 2000-04-14 | 2001-10-30 | Incyte Genomics, Inc. | Secreted proteins |
| WO2001083702A2 (en) | 2000-05-03 | 2001-11-08 | University Of Hawaii | Novel members of the lysyl oxidases family of amine oxidases related applications |
| WO2001092495A2 (en) | 2000-05-26 | 2001-12-06 | Millennium Pharmaceuticals, Inc. | A human lysyl ixodase (47765) and uses thereof |
| US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
| GB0014185D0 (en) * | 2000-06-09 | 2000-08-02 | Novartis Res Found | Compound and method |
| US20090233270A9 (en) | 2000-08-02 | 2009-09-17 | St Croix Brad | Secreted and cytoplasmic tumor endothelial markers |
| US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| EP2078531B1 (en) | 2000-08-08 | 2012-05-30 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis |
| JP2004505631A (ja) | 2000-08-08 | 2004-02-26 | ワイエス | リシルオキシダーゼ遺伝子ファミリーの新規メンバー |
| US20020156263A1 (en) * | 2000-10-05 | 2002-10-24 | Huei-Mei Chen | Genes expressed in breast cancer |
| AU2002241520A1 (en) | 2000-11-28 | 2003-03-03 | University Of Cincinnati | Blood assessment of injury |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7112668B2 (en) * | 2001-01-23 | 2006-09-26 | Curagen Corporation | Polypeptides and nucleic acids encoded thereby |
| US20040029114A1 (en) * | 2001-01-24 | 2004-02-12 | Eos Technology, Inc. | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
| WO2002061092A2 (en) | 2001-01-29 | 2002-08-08 | Bayer Aktiengesellschaft | Regulation of human lysyl oxidase |
| CA2438030A1 (en) | 2001-02-14 | 2002-10-10 | Protein Design Labs | Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
| CA2439504A1 (en) | 2001-02-28 | 2002-09-12 | Chondrogene Inc. | Compositions and methods relating to osteoarthritis |
| US20020182274A1 (en) * | 2001-03-21 | 2002-12-05 | Kung-Ming Lu | Methods for inhibiting cancer growth, reducing infection and promoting general health with a fermented soy extract |
| AU2002309583A1 (en) | 2001-04-18 | 2002-11-05 | Protein Desing Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| US20030211076A1 (en) | 2001-05-10 | 2003-11-13 | Wande Li | Compositions and methods for treatment of proliferative disorders |
| US20030092037A1 (en) | 2001-07-18 | 2003-05-15 | Osamu Matsuzaki | Elk1 phosphorylation related gene |
| FR2828206B1 (fr) | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| US20030129672A1 (en) | 2001-08-29 | 2003-07-10 | Dyer Richard Dennis | Method for identifying metalloenzyme inhibitors |
| CA2460476A1 (en) | 2001-10-12 | 2003-04-17 | Incyte Genomics, Inc. | Protein modification and maintenance molecules |
| WO2003035876A1 (de) | 2001-10-26 | 2003-05-01 | Ribopharma Ag | Verwendung einer doppelsträngigen ribonukleinsäure zur behandlung einer infektion mit einem (+)-strang-rna-virus |
| KR100450950B1 (ko) * | 2001-11-29 | 2004-10-02 | 삼성전자주식회사 | 구내/공중망 무선 패킷데이터 서비스를 받는 이동단말기의 인증 방법 및 그 사설망 시스템 |
| BR0207310A (pt) | 2001-12-18 | 2004-08-17 | Mondobiotech Sa | Composição farmacêutica de interferon gama ou de pirfenidona com diagnósticos moleculares para o melhor tratamento de doenças pulmonares intersticiais |
| US7186540B2 (en) | 2001-12-27 | 2007-03-06 | National Institute of Advanced Indusrtial Science and Technology | Thermostable glutaminase and thermostable glutaminase gene |
| JP2005536186A (ja) | 2002-03-07 | 2005-12-02 | ルードビッヒ、インスティテュート、フォー、キャンサー、リサーチ | リンパ管および血管内皮細胞遺伝子 |
| US7655397B2 (en) | 2002-04-25 | 2010-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers |
| WO2003100016A2 (en) | 2002-05-22 | 2003-12-04 | Incyte Corporation | Protein modification and maintenance molecules |
| CA2488441C (en) * | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| WO2004002427A2 (en) * | 2002-06-27 | 2004-01-08 | The General Hospital Corporation | Methods for the treatment or prevention of obesity |
| US20060127902A1 (en) | 2002-08-15 | 2006-06-15 | Genzyme Corporation | Brain endothelial cell expression patterns |
| WO2004023973A2 (en) | 2002-09-12 | 2004-03-25 | Incyte Corporation | Molecules for diagnostics and therapeutics |
| ATE513843T1 (de) * | 2002-09-25 | 2011-07-15 | Univ Massachusetts | Abstellen von genen in vivo durch chemischmodifizierte und stabile sirna |
| US20050260639A1 (en) | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Method for diagnosing pancreatic cancer |
| US20050259483A1 (en) | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Genes and polypeptides relating to prostate cancers |
| AU2003298786A1 (en) | 2002-11-26 | 2004-06-18 | Protein Design Labs, Inc. | Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators |
| JP5717937B2 (ja) | 2002-12-06 | 2015-05-13 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害療法を用いた患者の同定、判定および治療方法 |
| US20060188889A1 (en) | 2003-11-04 | 2006-08-24 | Christopher Burgess | Use of differentially expressed nucleic acid sequences as biomarkers for cancer |
| DE602004015064D1 (de) | 2003-01-06 | 2008-08-28 | Wyeth Corp | Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs |
| WO2004063355A2 (en) | 2003-01-10 | 2004-07-29 | Protein Design Labs, Inc. | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer |
| US7393531B2 (en) * | 2003-01-21 | 2008-07-01 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
| AU2004218407A1 (en) * | 2003-03-03 | 2004-09-16 | Board Of Regents, The University Of Texas System | Methods and compositions involving MDA-7 |
| US7641643B2 (en) * | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| AT500650B1 (de) * | 2003-04-17 | 2009-11-15 | Altropus Gmbh | Immunogener rekombinanter antikörper |
| KR20060015296A (ko) | 2003-05-23 | 2006-02-16 | 제넨테크, 인크. | 신경교 기원의 종양의 진단 및 치료를 위한 조성물 및 방법 |
| KR20060031809A (ko) | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
| FR2855968B1 (fr) * | 2003-06-13 | 2012-11-30 | Coletica | Stimulation de la synthese et de l'activite d'une isoforme de la lysyl oxydase-like loxl pour stimuler la formation de fibres elastiques |
| FR2855969B1 (fr) | 2003-06-13 | 2012-11-30 | Coletica | Stimulation de l'activite d'une isoforme de lysyl oxydase pour lutter contre certaines pathologies dues a une elastogenese incomplete, absente ou desorganisee |
| CN105316405A (zh) * | 2003-07-17 | 2016-02-10 | 环太平洋生物技术有限公司 | 用于胃癌检测的标记物 |
| JP2007505893A (ja) * | 2003-09-16 | 2007-03-15 | ハダシット メディカル リサーチ サービシーズ アンド ディベロップメント リミテッド | 免疫調節剤として使用される酢酸グラチラマー |
| AU2003271186A1 (en) | 2003-10-14 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
| JP4411280B2 (ja) | 2003-10-20 | 2010-02-10 | 帝人ファーマ株式会社 | 骨及び/又は関節疾患関連遺伝子 |
| US20070054278A1 (en) | 2003-11-18 | 2007-03-08 | Applera Corporation | Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof |
| TW200530269A (en) | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Anti-Mpl antibodies |
| WO2005094424A2 (en) | 2004-01-13 | 2005-10-13 | Trustees Of Boston University | Use of the pro-peptide domain of lysyl oxidase as a therapeutic agent |
| EP1706139A4 (en) | 2004-01-23 | 2009-06-17 | Massachusetts Eye & Ear Infirm | LYSYL OXIDASE-LIKE 1 (LOXL1) AND ELASTOGENESIS |
| US8142994B2 (en) | 2004-02-23 | 2012-03-27 | Erasmus University Medical Center Rotterdam | Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling |
| WO2005083107A2 (en) * | 2004-02-24 | 2005-09-09 | Attenuon Llp | Inhibition of superoxide dismutase by tetrathiomolybdate: identification of new anti-angiogenic and antitumor agents |
| WO2005100604A2 (en) | 2004-04-01 | 2005-10-27 | Sequenom, Inc. | Methods for identifying risk of osteoarthritis and treatments thereof |
| EP1799262A4 (en) * | 2004-10-15 | 2009-10-21 | Seattle Genetics Inc | ANTI-CD70 ANTIBODIES AND ITS USE FOR THE TREATMENT AND PREVENTION OF CANCER DISORDERS AND IMMUNE DISORDERS |
| WO2006068829A1 (en) | 2004-12-21 | 2006-06-29 | Alcon, Inc. | Agents which regulate, inhibit, or modulate the activity and/or expression of lysyl oxidase (lox) and lox-like proteases as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
| JP4171061B2 (ja) * | 2005-02-09 | 2008-10-22 | アーキュール,インコーポレーテッド | マレイミド誘導体、医薬組成物、および癌の治療のためのその使用 |
| WO2006094106A2 (en) * | 2005-02-28 | 2006-09-08 | Sangamo Biosciences, Inc. | Anti-angiogenic methods and compositions |
| US20060216722A1 (en) | 2005-03-25 | 2006-09-28 | Christer Betsholtz | Glomerular expression profiling |
| US9234897B2 (en) | 2005-03-31 | 2016-01-12 | Two Cells Co., Ltd | Method for distinguishing mesenchymal stem cell using molecular marker and use thereof |
| US8652786B2 (en) * | 2005-04-05 | 2014-02-18 | The General Hospital Corporation | Method for predicting responsiveness to drugs |
| WO2006128740A2 (en) | 2005-06-02 | 2006-12-07 | Centelion | Anti-vascular methods and therapies employing lysyl oxidase inhibitors |
| US20070225242A1 (en) * | 2005-06-21 | 2007-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method and composition for treating and preventing tumor metastasis in vivo |
| US20070021365A1 (en) * | 2005-06-21 | 2007-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto |
| JP5055284B2 (ja) | 2005-09-20 | 2012-10-24 | オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー | インシュリン様成長因子−1受容体キナーゼ阻害剤に対する抗癌応答を予測する生物学的マーカー |
| US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| US8158107B2 (en) * | 2005-09-30 | 2012-04-17 | National Jewish Health | Genes and proteins associated with angiogenesis and uses thereof |
| GB0521139D0 (en) | 2005-10-18 | 2005-11-23 | Univ Sheffield | Therapeutic agent |
| US20090035348A1 (en) | 2005-11-22 | 2009-02-05 | Z & Z Medical Holdings, Inc. | Dissolution of arterial plaque |
| US8445198B2 (en) | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| GB0524991D0 (en) | 2005-12-08 | 2006-01-18 | Ge Healthcare Ltd | Novel imaging agents for fibrosis |
| DK1960430T3 (da) * | 2005-12-09 | 2015-01-05 | Ucb Pharma Sa | Antistofmolekyler der har specificitet for humant il-6 |
| CA2639070A1 (en) | 2006-04-13 | 2007-11-01 | Oncomethylime Sciences S.A. | Novel tumour suppressor |
| SG172684A1 (en) | 2006-06-07 | 2011-07-28 | Bioalliance Cv | Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same |
| US20100092476A1 (en) | 2006-11-17 | 2010-04-15 | Hanash Samir M | Pancreatic cancer biomarkers |
| WO2008070616A2 (en) | 2006-12-01 | 2008-06-12 | University Of Utah Research Foundation | METHODS AND COMPOSITIONS RELATED TO HIF-1α |
| US8077896B2 (en) | 2006-12-12 | 2011-12-13 | Sound Services, Llc | Laser inclinometer audio direction |
| KR101443214B1 (ko) | 2007-01-09 | 2014-09-24 | 삼성전자주식회사 | 폐암 환자 또는 폐암 치료를 받은 폐암 환자의 폐암 재발 위험을 진단하기 위한 조성물, 키트 및 마이크로어레이 |
| GB0708002D0 (en) | 2007-04-25 | 2007-06-06 | Univ Sheffield | Antibodies |
| WO2008138578A2 (en) | 2007-05-11 | 2008-11-20 | Medical Prognosis Institute | Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| WO2008144720A2 (en) | 2007-05-21 | 2008-11-27 | University Of Washington | Inhibitors of igf-1r signaling for the treatment of respiratory disorders |
| EP3127549B1 (en) * | 2007-06-22 | 2019-12-18 | Children's Medical Center Corporation | Methods and uses thereof of a fragment of saposin a |
| IL184627A0 (en) | 2007-07-15 | 2008-12-29 | Technion Res & Dev Foundation | Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue |
| CA2693310C (en) * | 2007-08-02 | 2018-11-27 | Arresto Biosciences, Inc. | Lox and loxl2 inhibitors, antibodies and uses thereof |
| US8815946B2 (en) * | 2008-01-25 | 2014-08-26 | University of Pittsburgh—of the Commonwealth System of Higher Education | Inhibition of proliferation and fibrotic response of activated corneal stromal cells |
| JP2010038735A (ja) | 2008-08-05 | 2010-02-18 | Terumo Corp | 腹膜機能の評価方法および腹膜機能評価用イムノクロマト試験紙 |
| US9107935B2 (en) * | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
| SG173598A1 (en) * | 2009-02-06 | 2011-09-29 | Arresto Biosciences Inc | Methods and compositions for treatment of neovascularization |
| CN102711821A (zh) * | 2009-08-21 | 2012-10-03 | 吉联亚生物科技有限公司 | 治疗方法和组合物 |
| WO2011022670A1 (en) | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vivo screening assays |
| WO2011022709A1 (en) | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | In vitro screening assays |
| BR112012008111A2 (pt) * | 2009-08-21 | 2017-02-21 | Gilead Biologics Inc | métodos e composições para tratamento de desordens fibróticas pulmonares |
| WO2011022667A2 (en) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | Catalytic domains from lysyl oxidase and loxl2 |
| EP2482814A4 (en) | 2009-09-29 | 2013-04-03 | Gilead Biologics Inc | METHOD AND COMPOSITIONS FOR TREATING OKULAR FIBROSIS |
| MX2012009088A (es) | 2010-02-04 | 2012-12-05 | Gilead Biologics Inc | Anticuerpos que se enlazan a lisil oxidasa-tipo2 (loxl2) y metodos de uso para los mismos. |
| WO2012139045A1 (en) | 2011-04-08 | 2012-10-11 | Gilead Biologics, Inc. | Methods and compositions for normalization of tumor vasculature by inhibition of loxl2 |
| JP2014523521A (ja) | 2011-06-01 | 2014-09-11 | ギリアード バイオロジックス, インコーポレイテッド | リシルオキシダーゼ様2のアッセイおよびその使用の方法 |
| JP2016500700A (ja) | 2012-10-30 | 2016-01-14 | ギリアード サイエンシーズ, インコーポレイテッド | リシルオキシダーゼ様2(loxl2)に関する治療および診断方法 |
| US9708404B2 (en) * | 2012-12-21 | 2017-07-18 | Seattle Genetics, Inc. | Anti-NTB-A antibodies and related compositions and methods |
-
2008
- 2008-08-01 CA CA2693310A patent/CA2693310C/en not_active Expired - Fee Related
- 2008-08-01 WO PCT/US2008/072039 patent/WO2009035791A1/en not_active Ceased
- 2008-08-01 AU AU2008282739A patent/AU2008282739B2/en active Active
- 2008-08-01 EP EP12172222.7A patent/EP2537529B1/en not_active Not-in-force
- 2008-08-01 US US12/185,054 patent/US8679485B2/en active Active
- 2008-08-01 CN CN201510390365.4A patent/CN105330743B/zh not_active Expired - Fee Related
- 2008-08-01 CN CN200880110519A patent/CN101842114A/zh active Pending
- 2008-08-01 HU HUE08830207A patent/HUE025283T2/en unknown
- 2008-08-01 PL PL08830207T patent/PL2185198T3/pl unknown
- 2008-08-01 AU AU2008299784A patent/AU2008299784B9/en not_active Ceased
- 2008-08-01 CN CN201610065872.5A patent/CN105622756B/zh not_active Expired - Fee Related
- 2008-08-01 ES ES08830207.0T patent/ES2534490T3/es active Active
- 2008-08-01 ES ES08795003T patent/ES2402334T3/es active Active
- 2008-08-01 CA CA2693208A patent/CA2693208A1/en not_active Abandoned
- 2008-08-01 DK DK08830207.0T patent/DK2185198T3/en active
- 2008-08-01 SI SI200830930T patent/SI2182981T1/sl unknown
- 2008-08-01 DK DK08795003.6T patent/DK2182981T3/da active
- 2008-08-01 EP EP08795003A patent/EP2182981B1/en active Active
- 2008-08-01 ES ES12172222T patent/ES2700141T3/es active Active
- 2008-08-01 CN CN200880101321A patent/CN101835490A/zh active Pending
- 2008-08-01 PT PT12172222T patent/PT2537529T/pt unknown
- 2008-08-01 JP JP2010519263A patent/JP5312459B2/ja not_active Expired - Fee Related
- 2008-08-01 PL PL08795003T patent/PL2182981T3/pl unknown
- 2008-08-01 HR HRP20150208TT patent/HRP20150208T1/hr unknown
- 2008-08-01 HR HRP20130287AT patent/HRP20130287T1/hr unknown
- 2008-08-01 PT PT87950036T patent/PT2182981E/pt unknown
- 2008-08-01 US US12/185,050 patent/US8461303B2/en not_active Expired - Fee Related
- 2008-08-01 EP EP08830207.0A patent/EP2185198B1/en not_active Not-in-force
- 2008-08-01 CN CN201510392364.3A patent/CN105214085A/zh active Pending
- 2008-08-01 CN CN201910353780.0A patent/CN110372795A/zh active Pending
- 2008-08-01 PT PT8830207T patent/PT2185198E/pt unknown
- 2008-08-01 EP EP12172214.4A patent/EP2543389A3/en not_active Withdrawn
- 2008-08-01 JP JP2010519951A patent/JP5659014B2/ja active Active
- 2008-08-01 SI SI200831396T patent/SI2185198T1/sl unknown
- 2008-08-01 WO PCT/US2008/009354 patent/WO2009017833A2/en not_active Ceased
-
2011
- 2011-08-05 US US13/204,336 patent/US20120087917A1/en not_active Abandoned
-
2012
- 2012-12-06 US US13/707,495 patent/US8658167B2/en active Active
-
2013
- 2013-04-03 CY CY20131100280T patent/CY1113897T1/el unknown
- 2013-05-06 US US13/888,289 patent/US20140079707A1/en not_active Abandoned
- 2013-05-06 US US13/888,293 patent/US9176139B2/en not_active Expired - Fee Related
- 2013-05-31 JP JP2013116416A patent/JP5770219B2/ja not_active Expired - Fee Related
- 2013-12-19 US US14/135,178 patent/US20140128284A1/en not_active Abandoned
-
2014
- 2014-02-04 US US14/172,865 patent/US20140349309A1/en not_active Abandoned
- 2014-06-06 JP JP2014117893A patent/JP5851555B2/ja active Active
- 2014-07-21 AU AU2014204536A patent/AU2014204536B2/en not_active Ceased
-
2015
- 2015-03-30 CY CY20151100310T patent/CY1116178T1/el unknown
- 2015-06-23 JP JP2015125989A patent/JP2015212281A/ja active Pending
- 2015-10-07 US US14/877,655 patent/US20160185877A1/en not_active Abandoned
- 2015-12-02 JP JP2015235400A patent/JP2016094428A/ja active Pending
-
2016
- 2016-11-02 US US15/341,729 patent/US10494443B2/en not_active Expired - Fee Related
-
2017
- 2017-01-31 AU AU2017200635A patent/AU2017200635B9/en not_active Ceased
- 2017-05-11 JP JP2017095079A patent/JP6357264B2/ja not_active Expired - Fee Related
-
2018
- 2018-06-15 JP JP2018114560A patent/JP2018172398A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010535219A5 (enExample) | ||
| Zheng et al. | Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective | |
| Tanaka et al. | Hypoxia as a key player in the AKI-to-CKD transition | |
| Reiniger et al. | Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse | |
| Denby et al. | MicroRNA-214 antagonism protects against renal fibrosis | |
| Zarjou et al. | Identification of a microRNA signature in renal fibrosis: role of miR-21 | |
| Frisdal et al. | Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension | |
| Silva et al. | eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril | |
| Larsson et al. | Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression | |
| Gangadhariah et al. | Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid–mediated kidney injury in diabetic nephropathy | |
| Irita et al. | Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney | |
| Sharma et al. | Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation | |
| Gu et al. | Hydrogen sulfide attenuates renal fibrosis by inducing TET‐dependent DNA demethylation on klotho promoter | |
| JP2010516678A5 (enExample) | ||
| Naas et al. | Hypoxia and renal fibrosis | |
| Batchu et al. | Lung and kidney ACE2 and TMPRSS2 in renin-angiotensin system blocker–treated comorbid diabetic mice mimicking host factors that have been linked to severe COVID-19 | |
| Park et al. | Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer | |
| Zolak et al. | Idiopathic pulmonary fibrosis | |
| Kelly et al. | Cell-specific gene expression in patients with usual interstitial pneumonia | |
| Pan et al. | Pharmacologic inhibiting STAT3 delays the progression of kidney fibrosis in hyperuricemia-induced chronic kidney disease | |
| WO2009073575A3 (en) | Methods for treating induced cellular proliferative disorders | |
| Rebalka et al. | Inhibition of PAI-1 via PAI-039 improves dermal wound closure in diabetes | |
| Rafiq et al. | Regression of glomerular and tubulointerstitial injuries by dietary salt reduction with combination therapy of angiotensin II receptor blocker and calcium channel blocker in Dahl salt-sensitive rats | |
| Song et al. | CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway | |
| Herget‐Rosenthal et al. | Progress in uremic toxin research: uremic toxins in acute kidney injury |