JP2013534908A5 - - Google Patents

Info

Publication number

JP2013534908A5

JP2013534908A5 JP2013511636A JP2013511636A JP2013534908A5 JP 2013534908 A5 JP2013534908 A5 JP 2013534908A5 JP 2013511636 A JP2013511636 A JP 2013511636A JP 2013511636 A JP2013511636 A JP 2013511636A JP 2013534908 A5 JP2013534908 A5 JP 2013534908A5

Authority

JP

Japan

Prior art keywords

polynucleotide

mir

nucleic acid

composition

inhibitor

Prior art date

2011-05-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108091033319 polynucleotide Proteins 0.000 claims 21
• 102000040430 polynucleotide Human genes 0.000 claims 21
• 239000002157 polynucleotide Substances 0.000 claims 21
• 150000007523 nucleic acids Chemical group 0.000 claims 17
• 108091060585 Mir-31 Proteins 0.000 claims 11
• 102000001708 Protein Isoforms Human genes 0.000 claims 11
• 108010029485 Protein Isoforms Proteins 0.000 claims 11
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
• 239000003112 inhibitor Substances 0.000 claims 10
• 208000024172 Cardiovascular disease Diseases 0.000 claims 9
• 102100021262 Frizzled-3 Human genes 0.000 claims 9
• 101000819458 Homo sapiens Frizzled-3 Proteins 0.000 claims 9
• 101001061405 Homo sapiens Frizzled-9 Proteins 0.000 claims 9
• 238000000034 method Methods 0.000 claims 9
• 239000005557 antagonist Substances 0.000 claims 8
• 208000020084 Bone disease Diseases 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 6
• 238000009396 hybridization Methods 0.000 claims 5
• 239000002773 nucleotide Substances 0.000 claims 5
• 125000003729 nucleotide group Chemical group 0.000 claims 5
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 239000013068 control sample Substances 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 238000001727 in vivo Methods 0.000 claims 3
• 108091070501 miRNA Proteins 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 229940122938 MicroRNA inhibitor Drugs 0.000 claims 2
• 108700011259 MicroRNAs Proteins 0.000 claims 2
• 108020004688 Small Nuclear RNA Proteins 0.000 claims 2
• 102000039471 Small Nuclear RNA Human genes 0.000 claims 2
• 239000012472 biological sample Substances 0.000 claims 2
• 238000003745 diagnosis Methods 0.000 claims 2
• 108020004999 messenger RNA Proteins 0.000 claims 2
• 239000002679 microRNA Substances 0.000 claims 2
• 239000000523 sample Substances 0.000 claims 2
• 239000004055 small Interfering RNA Substances 0.000 claims 2
• 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
• 241000796533 Arna Species 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000010392 Bone Fractures Diseases 0.000 claims 1
• 206010017076 Fracture Diseases 0.000 claims 1
• 206010019280 Heart failures Diseases 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 206010061216 Infarction Diseases 0.000 claims 1
• 208000029725 Metabolic bone disease Diseases 0.000 claims 1
• 206010049088 Osteopenia Diseases 0.000 claims 1
• 208000001132 Osteoporosis Diseases 0.000 claims 1
• 108091007412 Piwi-interacting RNA Proteins 0.000 claims 1
• 208000001647 Renal Insufficiency Diseases 0.000 claims 1
• 108020003224 Small Nucleolar RNA Proteins 0.000 claims 1
• 102000042773 Small Nucleolar RNA Human genes 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 108091060271 Small temporal RNA Proteins 0.000 claims 1
• 208000006011 Stroke Diseases 0.000 claims 1
• 108091046869 Telomeric non-coding RNA Proteins 0.000 claims 1
• 208000007536 Thrombosis Diseases 0.000 claims 1
• 108091023040 Transcription factor Proteins 0.000 claims 1
• 102000040945 Transcription factor Human genes 0.000 claims 1
• 201000004810 Vascular dementia Diseases 0.000 claims 1
• 206010057469 Vascular stenosis Diseases 0.000 claims 1
• 239000011230 binding agent Substances 0.000 claims 1
• 230000037396 body weight Effects 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000001808 exosome Anatomy 0.000 claims 1
• -1 fRNA Proteins 0.000 claims 1
• 230000013632 homeostatic process Effects 0.000 claims 1
• 230000007574 infarction Effects 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 201000006370 kidney failure Diseases 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 239000002243 precursor Substances 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 238000012360 testing method Methods 0.000 claims 1
• 238000011200 topical administration Methods 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1