BR112012029656A2 - composições para uso no tratamento ou diagnóstico de disturbios ósseos e/ou distúrbios cardiovasculares - Google Patents

composições para uso no tratamento ou diagnóstico de disturbios ósseos e/ou distúrbios cardiovasculares

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Publication number
BR112012029656A2
BR112012029656A2 BR112012029656A BR112012029656A BR112012029656A2 BR 112012029656 A2 BR112012029656 A2 BR 112012029656A2 BR 112012029656 A BR112012029656 A BR 112012029656A BR 112012029656 A BR112012029656 A BR 112012029656A BR 112012029656 A2 BR112012029656 A2 BR 112012029656A2
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Prior art keywords
disorders
bone
compounds
compositions
polynucleotide
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BR112012029656A
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English (en)
Inventor
Elisabeth Schrami
Johannes Grillari
Klaus Fortschegger
Regina Grillari
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Uni Fur Bodenkultur Wien
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Uni Fur Bodenkultur Wien filed Critical Uni Fur Bodenkultur Wien
Publication of BR112012029656A2 publication Critical patent/BR112012029656A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs

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Abstract

composições para uso no tratamento ou diagnóstico de disturbios ósseos e/ou distúrbios cardiovasculares. a presente invenção refere-se a composições compreendendo um inibidor de um polinucleotídeo, o dito polinucleotídeo a ser inibido é capaz de diminuir ou suprimir a expressão de fzd3 (frizzled-3) ou um derivado biologicamente ativo desse para uso no tratamento ou prevenção de distúrbios ósseos e/ou distúrbios cardiovasculares. tais distúrbios ósseos compreendem, entre outros, osteoporose, osteopenia, fratura óssea, câncer ósseo, bem como homeostase óssea prejudicada. as doenças cardiovasculares a serem tratadas pelo compostos da presente invenção podem ser selecionadas a tratadas pelo compostos da presente invenção podem ser selecionadas a partir do grupo que consiste em infarto, derrame, hipertensão, trombose, estenose vascular, sídrome coronárias, demência vascular, insuficiência cardíaca, insuficiência renal, distúrbios cardiovasculares relacionados ao estresse e aterosclerose.os compostos preferenciais a serem usados nessas intervenções médicas são compostos antagonistas, como moléculas de ácido nucleico, direcionados contra mir-31 e seus derivados. a presente invenção também se refere a métodos para diagnóstico e composições para uso em diagnosticar distúrbios ósseos e/ou distúrbios cardiovasculares. os compostos a serem empregados nesse métodos diagnósticos e usos podem ser compostos (como iniciadores e sondas) que são capazes de detectar tal polinucleotídeo que é capa de diminuir ou suprimir a expressão de fzd3 ou um derivado biologicamente ativo deste. mir-31 é fornecido aqui como um polinucleotídeo que é capaz de diminuir ou suprimir a expressão de fzd3.
BR112012029656A 2010-05-21 2011-05-23 composições para uso no tratamento ou diagnóstico de disturbios ósseos e/ou distúrbios cardiovasculares BR112012029656A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10163604 2010-05-21
PCT/EP2011/058379 WO2011144761A1 (en) 2010-05-21 2011-05-23 Compositions for use in treating or diagnosing bone disorders and/or cardiovascular disorders

Publications (1)

Publication Number Publication Date
BR112012029656A2 true BR112012029656A2 (pt) 2016-12-13

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ID=44537805

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BR112012029656A BR112012029656A2 (pt) 2010-05-21 2011-05-23 composições para uso no tratamento ou diagnóstico de disturbios ósseos e/ou distúrbios cardiovasculares

Country Status (7)

Country Link
US (3) US20130108687A1 (pt)
EP (1) EP2571988B1 (pt)
JP (1) JP5894581B2 (pt)
CN (1) CN103210085B (pt)
BR (1) BR112012029656A2 (pt)
CA (1) CA2800018C (pt)
WO (1) WO2011144761A1 (pt)

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CN106687602B (zh) 2014-06-13 2021-12-28 维也纳自然资源与生命科学大学 用于诊断和治疗骨折和骨病的组合物及方法
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CN107176976B (zh) * 2016-03-11 2020-02-14 上海交通大学医学院 微小rna31前体编码多肽在制备免疫调节药物中的应用
CN107151695B (zh) * 2016-12-08 2021-11-09 青岛大学 用于检测急性心肌缺血疾病的piRNA组合及其检测方法和应用
CN110129429A (zh) * 2019-05-22 2019-08-16 昌乐县人民医院 核酸分子在制备诊断骨科疾病的产品中的应用
CN110055256A (zh) * 2019-05-31 2019-07-26 固安博健生物技术有限公司 Loc105376287作为诊断男性骨质疏松症的分子标志物的用途
CN110184270A (zh) * 2019-05-31 2019-08-30 固安博健生物技术有限公司 非编码rna作为男性骨质疏松症的诊断标志物
CN110951869B (zh) * 2020-01-02 2021-06-18 北京市创伤骨科研究所 骨质疏松诊治用生物标志物
CN111118139B (zh) * 2020-01-13 2021-06-18 北京市创伤骨科研究所 一种骨质疏松的分子靶标及其应用
CN111599476B (zh) * 2020-05-15 2023-08-11 中南大学湘雅医院 一种高血压的预测模型及其建立方法以及用于预测高血压的生物标记物
CN112746101B (zh) * 2020-12-25 2023-02-28 深圳市人民医院 一种骨质疏松诊断标志物及促进骨质疏松骨再生的核酸药物
CN114426950B (zh) * 2022-01-25 2023-08-04 北京大学口腔医学院 一种高成骨成血管的血清外泌体及其制备方法和应用

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Also Published As

Publication number Publication date
JP5894581B2 (ja) 2016-03-30
WO2011144761A1 (en) 2011-11-24
CA2800018A1 (en) 2011-11-24
US9212362B2 (en) 2015-12-15
US20150119450A1 (en) 2015-04-30
EP2571988B1 (en) 2019-11-20
US20130108687A1 (en) 2013-05-02
CN103210085A (zh) 2013-07-17
US20140162265A1 (en) 2014-06-12
US9150855B2 (en) 2015-10-06
EP2571988A1 (en) 2013-03-27
CA2800018C (en) 2021-09-28
JP2013534908A (ja) 2013-09-09
CN103210085B (zh) 2018-09-25

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