BR112018071602A2 - compostos de imidazopiridina substituídos como inibidores da indolamina 2,3-dioxigenase e/ou triptofano-2,3-dioxigenase - Google Patents
compostos de imidazopiridina substituídos como inibidores da indolamina 2,3-dioxigenase e/ou triptofano-2,3-dioxigenaseInfo
- Publication number
- BR112018071602A2 BR112018071602A2 BR112018071602-2A BR112018071602A BR112018071602A2 BR 112018071602 A2 BR112018071602 A2 BR 112018071602A2 BR 112018071602 A BR112018071602 A BR 112018071602A BR 112018071602 A2 BR112018071602 A2 BR 112018071602A2
- Authority
- BR
- Brazil
- Prior art keywords
- dioxigenase
- indolamine
- tryptophan
- inhibitors
- compounds
- Prior art date
Links
- TXQAZWIBPGKHOX-UHFFFAOYSA-N 1H-indol-3-amine Chemical compound C1=CC=C2C(N)=CNC2=C1 TXQAZWIBPGKHOX-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662329579P | 2016-04-29 | 2016-04-29 | |
US62/329,579 | 2016-04-29 | ||
PCT/US2017/029042 WO2017189386A1 (en) | 2016-04-29 | 2017-04-24 | Novel substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018071602A2 true BR112018071602A2 (pt) | 2019-02-12 |
BR112018071602B1 BR112018071602B1 (pt) | 2024-02-27 |
Family
ID=60161057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018071602-2A BR112018071602B1 (pt) | 2016-04-29 | 2017-04-24 | Compostos de imidazopiridina substituídos, sua composição e seus usos como inibidores da indolamina 2,3-dioxigenase e/ou triptofano-2,3- dioxigenase |
Country Status (11)
Country | Link |
---|---|
US (1) | US11096930B2 (pt) |
EP (1) | EP3448522B1 (pt) |
JP (1) | JP6948345B2 (pt) |
KR (1) | KR102456521B1 (pt) |
CN (1) | CN109069873B (pt) |
AU (1) | AU2017257377B2 (pt) |
BR (1) | BR112018071602B1 (pt) |
CA (1) | CA3021589A1 (pt) |
MX (1) | MX2018013164A (pt) |
RU (1) | RU2741911C2 (pt) |
WO (1) | WO2017189386A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3668880B1 (en) | 2017-08-17 | 2021-10-06 | Idorsia Pharmaceuticals Ltd | Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase |
JP7217279B2 (ja) | 2018-01-15 | 2023-02-02 | イドーシア ファーマシューティカルズ リミテッド | インドールアミン 2,3-ジオキシゲナーゼ及び/又はトリプトファン 2,3-ジオキシゲナーゼの阻害剤 |
EP3556760A1 (en) * | 2018-04-19 | 2019-10-23 | F. Hoffmann-La Roche AG | Spiro compounds |
WO2019204354A1 (en) | 2018-04-16 | 2019-10-24 | C4 Therapeutics, Inc. | Spirocyclic compounds |
WO2019206800A1 (en) * | 2018-04-24 | 2019-10-31 | Phenex Discovery Verwaltungs-GmbH | Spirocyclic compounds as modulators of indoleamine 2,3-dioxygenase |
WO2019245890A1 (en) | 2018-06-20 | 2019-12-26 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
US20220259212A1 (en) | 2019-07-11 | 2022-08-18 | Idorsia Pharmaceuticals Ltd | Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase |
KR102642194B1 (ko) | 2019-10-11 | 2024-03-05 | 삼성전자주식회사 | 전압 컨트롤러 및 이를 포함하는 메모리 장치 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
WO2008085302A1 (en) * | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
JP5612860B2 (ja) * | 2007-03-09 | 2014-10-22 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのイミダゾ[1,5−a]ピリジン誘導体 |
KR101783004B1 (ko) * | 2008-07-08 | 2017-09-28 | 인사이트 홀딩스 코포레이션 | 인돌아민 2,3-디옥시게나아제의 억제제로서의 1,2,5-옥사디아졸 |
CN104114557B (zh) * | 2012-02-21 | 2017-10-24 | 默克专利股份公司 | 作为syk酪氨酸激酶抑制剂和gcn2丝氨酸激酶抑制剂的8‑取代2‑氨基‑[1,2,4]三唑并[1,5‑a]吡嗪 |
SG10201707545XA (en) * | 2013-03-14 | 2017-10-30 | Newlink Genetics Corp | Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
PE20151594A1 (es) * | 2013-03-15 | 2015-11-19 | Bristol Myers Squibb Co | Inhibidores de indolamina 2-3 dioxigenasa |
US9931347B2 (en) * | 2013-12-03 | 2018-04-03 | Iomet Pharma Ltd. | Pharmaceutical compound |
KR102518994B1 (ko) * | 2014-05-28 | 2023-04-05 | 아스트라제네카 아베 | Azd5363의 제조 방법 및 그에 사용되는 신규 중간체 |
GB201414730D0 (en) * | 2014-08-19 | 2014-10-01 | Tpp Global Dev Ltd | Pharmaceutical compound |
EP3207030A4 (en) * | 2014-10-14 | 2018-06-06 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
JP6701214B2 (ja) | 2014-11-03 | 2020-05-27 | イオメット ファーマ リミテッド | 医薬化合物 |
GB201511790D0 (en) * | 2015-07-06 | 2015-08-19 | Iomet Pharma Ltd | Pharmaceutical compound |
-
2017
- 2017-04-24 WO PCT/US2017/029042 patent/WO2017189386A1/en active Application Filing
- 2017-04-24 EP EP17790165.9A patent/EP3448522B1/en active Active
- 2017-04-24 US US16/088,873 patent/US11096930B2/en active Active
- 2017-04-24 KR KR1020187034045A patent/KR102456521B1/ko active IP Right Grant
- 2017-04-24 MX MX2018013164A patent/MX2018013164A/es unknown
- 2017-04-24 CN CN201780026630.8A patent/CN109069873B/zh active Active
- 2017-04-24 CA CA3021589A patent/CA3021589A1/en active Pending
- 2017-04-24 AU AU2017257377A patent/AU2017257377B2/en active Active
- 2017-04-24 RU RU2018140732A patent/RU2741911C2/ru active
- 2017-04-24 BR BR112018071602-2A patent/BR112018071602B1/pt active IP Right Grant
- 2017-04-24 JP JP2018555971A patent/JP6948345B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
EP3448522A4 (en) | 2019-11-27 |
CN109069873B (zh) | 2021-07-20 |
MX2018013164A (es) | 2019-06-24 |
WO2017189386A1 (en) | 2017-11-02 |
AU2017257377B2 (en) | 2022-06-23 |
CA3021589A1 (en) | 2017-11-02 |
EP3448522A1 (en) | 2019-03-06 |
KR102456521B1 (ko) | 2022-10-20 |
KR20190003619A (ko) | 2019-01-09 |
RU2741911C2 (ru) | 2021-01-29 |
BR112018071602B1 (pt) | 2024-02-27 |
US20200230117A1 (en) | 2020-07-23 |
JP6948345B2 (ja) | 2021-10-13 |
CN109069873A (zh) | 2018-12-21 |
RU2018140732A (ru) | 2020-05-29 |
RU2018140732A3 (pt) | 2020-06-02 |
AU2017257377A1 (en) | 2018-10-11 |
JP2019515923A (ja) | 2019-06-13 |
EP3448522B1 (en) | 2021-01-20 |
US11096930B2 (en) | 2021-08-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018071602A2 (pt) | compostos de imidazopiridina substituídos como inibidores da indolamina 2,3-dioxigenase e/ou triptofano-2,3-dioxigenase | |
BR112018076534A2 (pt) | compostos heterocíclicos como imunomoduladores | |
BR112018012756A2 (pt) | compostos heterocíclicos como imunomoduladores | |
EA201990665A1 (ru) | Регуляторы hpk1 на основе производных пиразолопиридина и их применение для лечения рака | |
BR112015022462A8 (pt) | inibidores de ido, composição farmacêutica, método de inibição de atividade de indolamina 2,3-dioxigenase e uso dos referidos inibidores | |
BR112019005595A2 (pt) | compostos e métodos para modulação de ido e tdo, e indicações para os mesmos | |
BR112015032595A2 (pt) | inibidores de ido | |
EA201891674A1 (ru) | Ингибиторы лизилоксидаз, представляющие собой индольные и азаиндольные производные галогеналлиламина, и их применения | |
BR112017011923A2 (pt) | bactéria modificada para tratar doenças associadas com hiperamonemia | |
EA201790806A1 (ru) | Иммунорегулирующие средства | |
BR112017024384A2 (pt) | bactérias modificadas para reduzir hiperfenilalaninemia | |
EA201692177A1 (ru) | Соединения и композиции в качестве агонистов toll-подобного рецептора 7 | |
BR112015021999A2 (pt) | inibidores de indoleamina 2,3-dioxigenase (ido) | |
EA201792047A1 (ru) | Новые соединения | |
EA201791867A1 (ru) | Бициклические гетероциклы как ингибиторы fgfr4 | |
BR112017009671A2 (pt) | inibidores de ezh2 e usos destes | |
BR112016028255A2 (pt) | agentes imunorreguladores | |
BR112014026703A2 (pt) | inibidores de dna-pk | |
BR112017009647A2 (pt) | 2-amino-3,5-difluoro-3,6-dimetil-6-fenil-3,4,5,6-tetraidropiridinas como inibidoras da bace1 para tratar a doença de alzheimer | |
BR112015026307A2 (pt) | heterociclo bicíclicos como inibidores de fgfr | |
EA201890086A1 (ru) | 1,4-замещенные производные пиперидина | |
BR112015022545A2 (pt) | compostos de pirazolo e os usos disso | |
BR112014030812A2 (pt) | "compostos tricíclicos substituídos como inibidores de fgfr, seus usos, composição farmacêutica e método para inibir uma enzima fgfr" | |
WO2015117010A3 (en) | Bag3 as a target for therapy of heart failure | |
BR112018013820A2 (pt) | análogos de egf(a) com substituintes de ácido graxo |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: IOMET PHARMA LTD. (GB) ; MERCK SHARP AND DOHME LLC (US) |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/04/2017, OBSERVADAS AS CONDICOES LEGAIS |