MXPA05005923A - Metodos para la identificacion, valoracion y tratamiento de pacientes con terapia para la inhibicion de la proteasoma. - Google Patents
Metodos para la identificacion, valoracion y tratamiento de pacientes con terapia para la inhibicion de la proteasoma.Info
- Publication number
- MXPA05005923A MXPA05005923A MXPA05005923A MXPA05005923A MXPA05005923A MX PA05005923 A MXPA05005923 A MX PA05005923A MX PA05005923 A MXPA05005923 A MX PA05005923A MX PA05005923 A MXPA05005923 A MX PA05005923A MX PA05005923 A MXPA05005923 A MX PA05005923A
- Authority
- MX
- Mexico
- Prior art keywords
- markers
- identification
- treatment
- patients
- proteasome inhibition
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
Abstract
La presente invencion se refiere a la identificacion de marcadores que pueden usarse para determinar si los pacientes con cancer responden o no responden clinicamente a un regimen terapeutico antes del tratamiento. En particular, la presente invencion se refiere al uso de ciertas combinaciones de marcadores, en donde la expresion de los marcadores se correlaciona con la respuesta o no respuesta a un regimen terapeutico que comprende la inhibicion de la proteasoma. Asi, al examinar los niveles de expresion de ,arcadores individuales y aquellos que comprenden un juego marcador, es posible determinar si un agente terapeutico o combinacion de agentes ayudara a reducir el indice de crecimiento de tumores en un medio clinico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43151402P | 2002-12-06 | 2002-12-06 | |
PCT/US2003/038539 WO2004053066A2 (en) | 2002-12-06 | 2003-12-04 | Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05005923A true MXPA05005923A (es) | 2005-09-21 |
Family
ID=32507743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05005923A MXPA05005923A (es) | 2002-12-06 | 2003-12-04 | Metodos para la identificacion, valoracion y tratamiento de pacientes con terapia para la inhibicion de la proteasoma. |
Country Status (9)
Country | Link |
---|---|
US (3) | US20040156854A1 (es) |
EP (1) | EP1581629B1 (es) |
JP (2) | JP5717937B2 (es) |
AU (1) | AU2003298873B2 (es) |
CA (1) | CA2508348C (es) |
ES (1) | ES2542328T3 (es) |
HK (1) | HK1086027A1 (es) |
MX (1) | MXPA05005923A (es) |
WO (1) | WO2004053066A2 (es) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080050836A1 (en) * | 1998-05-01 | 2008-02-28 | Isabelle Guyon | Biomarkers for screening, predicting, and monitoring benign prostate hyperplasia |
US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
US20090215024A1 (en) * | 2001-01-24 | 2009-08-27 | Health Discovery Corporation | Biomarkers upregulated in prostate cancer |
US20090226915A1 (en) * | 2001-01-24 | 2009-09-10 | Health Discovery Corporation | Methods for Screening, Predicting and Monitoring Prostate Cancer |
US20090215058A1 (en) * | 2001-01-24 | 2009-08-27 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
WO2004052184A2 (en) * | 2002-12-12 | 2004-06-24 | Oncotech, Inc. | Genes related to sensitivity and resistance to chemotherapeutic drug treatment |
CA2558014A1 (en) * | 2004-03-12 | 2005-09-29 | Entremed, Inc. | Antiangiogenic agents |
CA3002661C (en) | 2004-05-21 | 2022-03-15 | The Board Of Trustees Of The University Of Arkansas | Use of gene expression profiling to predict survival in cancer patient |
WO2006053328A2 (en) * | 2004-11-12 | 2006-05-18 | Health Discovery Corporation | Biomarkers for screening, predicting, and monitoring prostate disease |
WO2006101535A1 (en) * | 2005-03-23 | 2006-09-28 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Inhibition of proteasome function to potentiate the proapoptotic and antitumor activity of cytokines |
JP4887505B2 (ja) * | 2005-04-18 | 2012-02-29 | 国立大学法人浜松医科大学 | 癌の転移性及び浸潤能の検査方法 |
WO2006133420A2 (en) * | 2005-06-08 | 2006-12-14 | Millennium Pharmaceuticals, Inc. | Treatment of patients with cancer therapy |
US20090017006A1 (en) * | 2005-07-06 | 2009-01-15 | Biodevelops Pharma Entwicklung Gmbh | Use of a compound for enhancing the expression of membrane proteins on the cell surface |
WO2007022041A2 (en) * | 2005-08-11 | 2007-02-22 | Novartis Ag | Mutations and polymorphisms of hdac3 |
JP2009509171A (ja) * | 2005-09-21 | 2009-03-05 | シーシーシー ダイアグノスティックス, エルエルシー | 個別化抗癌化学療法(pac)のための包括的な診断試験 |
US20070197473A1 (en) * | 2005-11-04 | 2007-08-23 | Frankel Stanley R | Methods of using SAHA and Bortezomib for treating cancer |
US7894650B2 (en) * | 2005-11-10 | 2011-02-22 | Microsoft Corporation | Discover biological features using composite images |
US20070185069A1 (en) * | 2005-11-14 | 2007-08-09 | Plum Stacy M | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
CN100372568C (zh) * | 2005-12-09 | 2008-03-05 | 中国科学院广州生物医药与健康研究院 | 化合物mg-132在制备治疗白血病药物中的应用 |
US7875274B2 (en) * | 2005-12-16 | 2011-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Protein modulators of resistance to alkylating agents |
WO2007103770A2 (en) * | 2006-03-02 | 2007-09-13 | Ppd Biomarker Discovery Sciences, Llc | Compositions and methods for analyzing renal cancer |
JP2009530388A (ja) * | 2006-03-20 | 2009-08-27 | エントレメッド インコーポレイテッド | 2−メトキシエストラジオールの疾患修飾性抗関節炎活性 |
EP2021502A4 (en) * | 2006-05-09 | 2010-08-25 | Mas Metabolic Analytical Servi | GENES AND ATYPICAL MARKERS IN TYPE 2 DIABETES AND OBESITY |
NZ597545A (en) | 2006-06-19 | 2013-07-26 | Proteolix Inc | Peptide epoxyketones for proteasome inhibition |
WO2008021183A2 (en) * | 2006-08-10 | 2008-02-21 | Millennium Pharmaceuticals, Inc. | For the identification, assessment, and treatment of patients with cancer therapy |
JP2010509221A (ja) * | 2006-11-03 | 2010-03-25 | ユニバーシテイ・オブ・メリーランド,ボルテイモア | 多発性骨髄腫を治療するためにsahaおよびボルテゾミブを使用する方法 |
JP5413818B2 (ja) * | 2007-03-29 | 2014-02-12 | 国立大学法人佐賀大学 | 蛍光多重染色による蛋白定量法 |
EP2155231B1 (en) * | 2007-04-10 | 2012-08-08 | The Johns Hopkins University | Imaging and therapy of virus-associated tumors |
US20080317768A1 (en) * | 2007-06-21 | 2008-12-25 | Boeing Company | Bioconjugated nanoparticles |
CN110372795A (zh) | 2007-08-02 | 2019-10-25 | 吉利德生物制剂公司 | Lox和loxl2抑制剂及其应用 |
US20110118274A1 (en) * | 2007-08-23 | 2011-05-19 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
US7816084B2 (en) | 2007-11-30 | 2010-10-19 | Applied Genomics, Inc. | TLE3 as a marker for chemotherapy |
US20090177450A1 (en) * | 2007-12-12 | 2009-07-09 | Lawrence Berkeley National Laboratory | Systems and methods for predicting response of biological samples |
US20100086922A1 (en) * | 2008-05-30 | 2010-04-08 | Millennium Pharmaceuticals, Inc. | Assessment of chromosomal alterations to predict clinical outcome of bortezomib treatment |
US8321144B2 (en) * | 2008-10-23 | 2012-11-27 | Microsoft Corporation | Non-contiguous regions processing |
EP2342355A4 (en) * | 2008-10-29 | 2012-06-27 | Beaumont Hospital William | METHODS OF USING BIOMARKERS |
CA2748759A1 (en) * | 2009-01-02 | 2010-07-08 | The Board Of Trustees Of The University Of Arkansas | Uses of bortezomib in predicting survival in multiple myeloma patients |
US9107935B2 (en) * | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
US20110207144A1 (en) * | 2009-08-21 | 2011-08-25 | Derek Marshall | In vitro screening assays |
BR112012008084A2 (pt) * | 2009-08-21 | 2019-09-24 | Gilead Biologics Inc | método terapêuticos e composições. |
NZ625850A (en) * | 2009-08-21 | 2015-12-24 | Gilead Biologics Inc | Methods and compositions for treatment of pulmonary fibrotic disorders |
MX2012002272A (es) * | 2009-08-21 | 2012-07-03 | Gilead Biologics Inc | Dominios cataliticos de lisil oxidasa y loxl2. |
US20110044907A1 (en) * | 2009-08-21 | 2011-02-24 | Derek Marshall | In vivo screening assays |
US8853147B2 (en) * | 2009-11-13 | 2014-10-07 | Onyx Therapeutics, Inc. | Use of peptide epoxyketones for metastasis suppression |
WO2011085216A2 (en) | 2010-01-08 | 2011-07-14 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating parkinson's disease and restless legs syndrome |
WO2011094806A1 (en) * | 2010-02-03 | 2011-08-11 | Monash University | Diagnostic and prognostic assay for breast cancer |
AU2011212830B2 (en) | 2010-02-04 | 2014-05-22 | Gilead Biologics, Inc. | Antibodies that bind to lysyl oxidase-like 2 (LOXL2) and methods of use therefor |
WO2011123719A2 (en) | 2010-03-31 | 2011-10-06 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating abdominal, visceral and pelvic pain |
JP5740880B2 (ja) | 2010-09-15 | 2015-07-01 | 株式会社リコー | 画像形成装置、及びプログラム |
EP2742356B1 (en) | 2011-08-11 | 2016-04-27 | Janssen Pharmaceutica N.V. | Predictors for cancer treatment |
EP2776586B1 (en) * | 2011-11-11 | 2018-03-07 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to proteasome inhibitors |
US9428813B2 (en) | 2012-03-26 | 2016-08-30 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | DNA methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms |
WO2014078571A1 (en) * | 2012-11-14 | 2014-05-22 | The Board Of Trustees Of The University Of Arkansas | Methods of detecting 14q32 translocations |
CA2912312C (en) | 2013-05-20 | 2023-01-24 | Board Of Trustees Of The University Of Arkansas | Gep5 model for multiple myeloma |
EP3594359B1 (en) | 2013-11-06 | 2022-05-18 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Method for subtyping lymphoma types by means of expression profiling |
EP3146067A1 (en) * | 2014-05-20 | 2017-03-29 | Erasmus University Medical Center Rotterdam | Method for the treatment of multiple myeloma |
US10607152B2 (en) * | 2015-05-26 | 2020-03-31 | Textio, Inc. | Using machine learning to predict outcomes for documents |
US20170159130A1 (en) * | 2015-12-03 | 2017-06-08 | Amit Kumar Mitra | Transcriptional classification and prediction of drug response (t-cap dr) |
CN108290622B (zh) | 2015-12-30 | 2020-07-17 | 现代重工业株式会社 | 液化气体运输船 |
CA3021569A1 (en) | 2016-04-20 | 2017-10-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Evaluation of mantle cell lymphoma and methods related thereto |
CN106928370B (zh) * | 2016-09-26 | 2021-02-02 | 华东师范大学 | 一种REGγ-20S蛋白酶体抑制剂的筛选系统及其应用 |
KR102007664B1 (ko) * | 2017-07-17 | 2019-08-07 | 김준 | 암 진단기 및 이를 이용한 암 진단시스템 |
US11804298B2 (en) | 2017-07-17 | 2023-10-31 | Joon Kim | Cancer diagnostic apparatus and cancer diagnostic system using the same |
US11899022B2 (en) | 2017-08-23 | 2024-02-13 | The General Hospital Corporation | Multiplexed proteomics and predictive drug candidate assessment |
EP3502279A1 (en) * | 2017-12-20 | 2019-06-26 | Koninklijke Philips N.V. | Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression |
WO2019142136A1 (en) * | 2018-01-17 | 2019-07-25 | Ods Medical Inc. | System and methods for real-time raman spectroscopy for cancer detection |
CN110499287B (zh) * | 2019-08-30 | 2021-07-23 | 博雅干细胞科技有限公司 | 简易制备胎盘间充质干细胞外泌体的方法 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IL97428A0 (en) | 1990-03-05 | 1992-06-21 | Cephalon Inc | Chymotrypsin-like proteases and their inhibitors |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
DE69326967T2 (de) | 1992-01-17 | 2000-06-15 | Lakowicz Joseph R | Phasenmodulationsenergieübertragungsfluoroimmunassay |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5693617A (en) | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
US6660268B1 (en) | 1994-03-18 | 2003-12-09 | The President And Fellows Of Harvard College | Proteasome regulation of NF-KB activity |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US6335358B1 (en) | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
GB9704444D0 (en) * | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
US6355623B2 (en) * | 1998-09-24 | 2002-03-12 | Hopital-Sainte-Justine | Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage |
WO2001002567A1 (en) * | 1999-07-02 | 2001-01-11 | Millennium Pharmaceuticals, Inc. | 16405 receptor, a g-protein coupled receptor |
AU2001239941A1 (en) * | 2000-02-29 | 2001-09-12 | The General Hospital Corporation | Beta netrin and uses thereof |
US20040006205A1 (en) * | 2001-04-03 | 2004-01-08 | Li Li | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
US20030185815A1 (en) * | 2001-04-03 | 2003-10-02 | Muralidhara Padigaru | Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use |
EP1392361A4 (en) * | 2001-05-11 | 2009-08-05 | Univ Texas | THERAPY BASED ON ANTI-CD26 MONOCLONAL ANTIBODIES AGAINST DISORDERS ASSOCIATED WITH CELLS EXPRESSING CD26 |
WO2006133420A2 (en) * | 2005-06-08 | 2006-12-14 | Millennium Pharmaceuticals, Inc. | Treatment of patients with cancer therapy |
US8067152B2 (en) * | 2006-02-27 | 2011-11-29 | The Fred Hutchinson Cancer Research Center | Liver cancer biomarkers |
-
2003
- 2003-12-04 MX MXPA05005923A patent/MXPA05005923A/es active IP Right Grant
- 2003-12-04 WO PCT/US2003/038539 patent/WO2004053066A2/en active Search and Examination
- 2003-12-04 AU AU2003298873A patent/AU2003298873B2/en not_active Ceased
- 2003-12-04 ES ES03796633.0T patent/ES2542328T3/es not_active Expired - Lifetime
- 2003-12-04 EP EP03796633.0A patent/EP1581629B1/en not_active Revoked
- 2003-12-04 JP JP2004559278A patent/JP5717937B2/ja not_active Expired - Lifetime
- 2003-12-04 US US10/728,055 patent/US20040156854A1/en not_active Abandoned
- 2003-12-04 CA CA2508348A patent/CA2508348C/en not_active Expired - Fee Related
-
2006
- 2006-04-06 HK HK06104178.0A patent/HK1086027A1/xx not_active IP Right Cessation
-
2008
- 2008-12-16 US US12/316,756 patent/US20090181393A1/en not_active Abandoned
-
2010
- 2010-04-13 JP JP2010092346A patent/JP5896593B2/ja not_active Expired - Fee Related
-
2016
- 2016-03-25 US US15/080,709 patent/US20170023577A1/en not_active Abandoned
Also Published As
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US20040156854A1 (en) | 2004-08-12 |
JP2010207230A (ja) | 2010-09-24 |
JP2006517093A (ja) | 2006-07-20 |
CA2508348A1 (en) | 2004-06-24 |
AU2003298873A1 (en) | 2004-06-30 |
US20170023577A1 (en) | 2017-01-26 |
WO2004053066A3 (en) | 2006-09-08 |
CA2508348C (en) | 2016-07-12 |
AU2003298873B2 (en) | 2011-09-01 |
WO2004053066A2 (en) | 2004-06-24 |
EP1581629A4 (en) | 2007-05-16 |
JP5896593B2 (ja) | 2016-03-30 |
EP1581629B1 (en) | 2015-04-01 |
ES2542328T3 (es) | 2015-08-04 |
HK1086027A1 (en) | 2006-09-08 |
EP1581629A2 (en) | 2005-10-05 |
JP5717937B2 (ja) | 2015-05-13 |
US20090181393A1 (en) | 2009-07-16 |
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