MX2010005081A - Metodo para determinar la probabilidad de una respuesta terapeutica en la quimioterapia para el cancer con un glicosido cardiaco. - Google Patents
Metodo para determinar la probabilidad de una respuesta terapeutica en la quimioterapia para el cancer con un glicosido cardiaco.Info
- Publication number
- MX2010005081A MX2010005081A MX2010005081A MX2010005081A MX2010005081A MX 2010005081 A MX2010005081 A MX 2010005081A MX 2010005081 A MX2010005081 A MX 2010005081A MX 2010005081 A MX2010005081 A MX 2010005081A MX 2010005081 A MX2010005081 A MX 2010005081A
- Authority
- MX
- Mexico
- Prior art keywords
- cardiac glycoside
- kit
- assay
- therapeutic response
- probability
- Prior art date
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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Abstract
Se proporciona un ensayo de pronóstico y un equipo y un método para el uso del mismo. El equipo y el ensayo se utilizan para determinar la probabilidad de que una célula o tejido enfermo tenga una respuesta terapéutica a un tratamiento con un glicósido cardíaco en una enfermedad que tiene una etiología asociada con la proliferación excesiva de células. El equipo y el ensayo se utilizan para determinar la relación de isoformas de la subunidad a de Na,K-ATPasa obtenida de la célula o tejido enfermo. El equipo se puede utilizar para predecir la sensibilidad terapéutica del cáncer o tumor en un sujeto a un tratamiento con un glicósido cardíaco. El equipo y el ensayo se pueden incorporar en un método para tratar una enfermedad o un trastorno que tiene una etiología asociada con la proliferación excesiva de células con una composición que comprende un glicósido cardíaco.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98750107P | 2007-11-13 | 2007-11-13 | |
PCT/US2008/082641 WO2009064657A1 (en) | 2007-11-13 | 2008-11-06 | Method of determining the probability of a therapeutic response in cancer chemotherapy with cardiac glycoside |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010005081A true MX2010005081A (es) | 2010-06-23 |
Family
ID=40639083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010005081A MX2010005081A (es) | 2007-11-13 | 2008-11-06 | Metodo para determinar la probabilidad de una respuesta terapeutica en la quimioterapia para el cancer con un glicosido cardiaco. |
Country Status (12)
Country | Link |
---|---|
US (4) | US8367363B2 (es) |
EP (1) | EP2231165B1 (es) |
JP (1) | JP5358583B2 (es) |
KR (1) | KR101556805B1 (es) |
CN (1) | CN101909637B (es) |
AU (1) | AU2008321225B2 (es) |
BR (1) | BRPI0820564A2 (es) |
CA (1) | CA2705272C (es) |
ES (1) | ES2414057T3 (es) |
MX (1) | MX2010005081A (es) |
RU (2) | RU2508114C2 (es) |
WO (1) | WO2009064657A1 (es) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
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TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
CA2705272C (en) | 2007-11-13 | 2020-05-12 | Phoenix Biotechnology Inc. | Method of determining the probability of a therapeutic response in cancer chemotherapy with cardiac glycoside |
US10307450B2 (en) | 2010-01-11 | 2019-06-04 | Phoenix Biotechnology, Inc. | Method of treating neurological conditions with extract of Nerium species or Thevetia species |
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Cited By (3)
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US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
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KR20100087730A (ko) | 2010-08-05 |
JP2011508184A (ja) | 2011-03-10 |
ES2414057T3 (es) | 2013-07-18 |
CA2705272C (en) | 2020-05-12 |
WO2009064657A1 (en) | 2009-05-22 |
AU2008321225B2 (en) | 2013-08-01 |
RU2013151251A (ru) | 2015-05-27 |
KR101556805B1 (ko) | 2015-10-01 |
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RU2571687C2 (ru) | 2015-12-20 |
BRPI0820564A2 (pt) | 2017-05-23 |
EP2231165A1 (en) | 2010-09-29 |
RU2508114C2 (ru) | 2014-02-27 |
US9494589B2 (en) | 2016-11-15 |
JP5358583B2 (ja) | 2013-12-04 |
CN101909637A (zh) | 2010-12-08 |
AU2008321225A1 (en) | 2009-05-22 |
CA2705272A1 (en) | 2009-05-22 |
RU2010123795A (ru) | 2011-12-20 |
EP2231165A4 (en) | 2010-12-15 |
US20100317541A1 (en) | 2010-12-16 |
US8367363B2 (en) | 2013-02-05 |
US20150316550A1 (en) | 2015-11-05 |
EP2231165B1 (en) | 2013-05-15 |
CN101909637B (zh) | 2013-09-18 |
US9846156B2 (en) | 2017-12-19 |
US20130324485A1 (en) | 2013-12-05 |
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