WO2005100604A2 - Methods for identifying risk of osteoarthritis and treatments thereof - Google Patents

Methods for identifying risk of osteoarthritis and treatments thereof Download PDF

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Publication number
WO2005100604A2
WO2005100604A2 PCT/US2005/010912 US2005010912W WO2005100604A2 WO 2005100604 A2 WO2005100604 A2 WO 2005100604A2 US 2005010912 W US2005010912 W US 2005010912W WO 2005100604 A2 WO2005100604 A2 WO 2005100604A2
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Prior art keywords
nucleotide sequence
seq
osteoarthritis
polymorphic
polypeptide
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PCT/US2005/010912
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French (fr)
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WO2005100604A8 (en
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Steven Mah
Andreas Braun
Stefan M. Kammerer
Matthew Roberts Nelson
Rikard Henry Reneland
Maria L. Langdown
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Sequenom, Inc.
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Priority to EP05768810A priority Critical patent/EP1756317A4/en
Priority to CA002561742A priority patent/CA2561742A1/en
Publication of WO2005100604A2 publication Critical patent/WO2005100604A2/en
Publication of WO2005100604A8 publication Critical patent/WO2005100604A8/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone

Definitions

  • the invention relates to genetic methods for identifying risk of osteoarthritis and treatments that specifically target such diseases.
  • Osteoarthritis is a chronic disease usually affecting weight-bearing synovial joints. There are approximately 20 million Americans affected by OA and it is the leading cause of disability in the United States. In addition to extensive human suffering, OA also accounts for nearly all knee replacements and more than half of all hip replacements in the United States. Despite its prevalence, OA is poorly understood and there are few treatments available besides anti-inflammatory drugs and joint replacement. [0003] Osteoarthritis (OA) is a disease caused by degeneration of articular cartilage and subsequent joint deformation. In addition to risk factors like body weight, joint injury and age, there is a strong hereditary component to OA, reflected by high heritability estimates from twin studies. So far, few- of the genes responsible for this genetic component have been identified.
  • a subject at risk of osteoarthritis and/or a risk of osteoarthritis in a subject which comprise detecting the presence or absence of one or more polymorphic variations associated with osteoartliritis in or around the loci described herein in a human nucleic acid sample.
  • two or more polymorphic variations are detected in two or more regions of which one is the PADI2, APOB, IL1RL2, IL1RL1, WASPIP, ADAMTS2, BVES, TM7SF3, LOXL1, CASPR4 or APOL3 region or other region in Table B.
  • nucleic acids that include one or more polymorphic variations associated with occurrence of osteoarthritis, as well as polypeptides encoded by these nucleic acids.
  • methods for identifying candidate therapeutic molecules for treating osteoarthritis, as well as methods for treating osteoarthritis in a subject by identifying a subject at risk of osteoarthritis and treating the subject with a suitable prophylactic, treatment or therapeutic molecule are also featured.
  • compositions comprising a cell from a subject having osteoarthritis or at risk of osteoarthritis and/or a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 o ⁇ APOL3 nucleic acid or other nucleic acid referenced in Table B, with a RNAi, siRNA, antisense DNA or RNA, or ribozyme nucleic acid designed from a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B.
  • the RNAi, siRNA, antisense DNA or RNA, or ribozyme nucleic acid is designed from a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B that includes one or more polymorphic variations associated with osteoarthritis, and in some instances, specifically interacts with such a nucleotide sequence.
  • nucleic acids bound to a solid surface in which one or more nucleic acid molecules of the array have a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a fragment or substantially identical nucleic acid thereof, or a complementary nucleic acid of the foregoing.
  • compositions comprising a cell from a subject having osteoartliritis or at risk of osteoarthritis and/or a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 polypeptide or other polypeptide referenced in Table B, with an antibody that specifically binds to the polypeptide.
  • the antibody specifically binds to an epitope in the polypeptide that includes a non-synonymous amino acid modification associated with osteoarthritis (e.g., results in an amino acid substitution in the encoded polypeptide associated with osteoarthritis).
  • the antibody selectively binds to an epitope in the PADI2, APOB, IL1RL2, ILIRLI, WASPIP, AOAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 polypeptide, or other polypeptide referenced in Table B, having an amino acid associated with osteoarthritis.
  • an antibody that binds an epitope having an amino acid encoded by rsl367117, rsl041973 and/or rs398829, such as a isoleucine or threonine encoded by rsl 367117 (e.g., a threonine at position 98 in an APOB polypeptide), a glutamic acid or alanine encoded by rsl041973 (e.g., an alanine at position 78 in a ILIRLI polypeptide), a valine or isoleucine encoded by rs398829 (e.g., a valine at position 245 in a ADAMTS2 polypeptide), at the corresponding position in the polypeptide.
  • a isoleucine or threonine encoded by rsl 367117 e.g., a threonine at position 98 in an APOB polypeptide
  • Figures 1A-1J show proximal SNPs in a 100-kb window in PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 ⁇ ndAPOL3 regions of genomic DNA, respectively, that were compared between pools of cases and controls.
  • the x-axis corresponds to their chromosomal position and the y-axis to the test P-values (shown on the -log 10 scale).
  • the continuous bold line presents the results of a goodness-of-fit test for an excess of significance (compared to 0.05) in a 10 kb sliding window assessed at 1 kb increments.
  • Osteoarthritis or degenerative joint disease, is one of the oldest and most common types of arthritis. It is characterized by the breakdown of the joint's cartilage. Cartilage is the part of the joint that cushions the ends of bones, and its breakdown causes bones to rub against each other, causing pain and loss of movement.
  • Type II collagen is the main component of cartilage, comprising 15-25% of the wet weight, approximately half the dry weight, and representing 90-95% of the total collagen content in the tissue. It forms fibrils that endow cartilage with tensile strength (Mayne, R. Arthritis Rhuem. 32:241-246 (1989)). [0011] Most commonly affecting middle-aged and older people, OA can range from very mild to very severe. It affects hands and weight-bearing joints such as knees, hips, feet and the back. Knee OA can be as disabling as any cardiovascular disease except stroke. [0012] Osteoarthritis affects an estimated 20.7 million Americans, mostly after age 45, with women more commonly affected than men.
  • Inclusion or exclusion of samples for an osteoarthritis pool may be based upon the following criteria: ethnicity (e.g., samples derived from an individual characterized as Caucasian); parental ethnicity (e.g., samples derived from an individual of British paternal and maternal descent); relevant phenotype information for the individual (e.g., case samples derived from individuals diagnosed with specific knee, hand or hip osteoarthritis (OA); case samples recruited from an OA knee replacement clinic). Control samples may be selected based on relevant phenotype information for the individual (e.g., derived from individuals free of OA at several sites (knee, hand, hip etc)); and no family history of OA and/or rheumatoid arthritis.
  • ethnicity e.g., samples derived from an individual characterized as Caucasian
  • parental ethnicity e.g., samples derived from an individual of British paternal and maternal descent
  • relevant phenotype information for the individual e.g., case samples derived from individuals diagnosed with specific
  • Additional phenotype information collected for both cases and controls may include age of the individual, gender, family history of OA, diagnosis with osteoarthritis (joint location of OA (e.g., knee, hips, hands and spine), date of primary diagnosis, age of individual as of primary diagnosis), knee history (current symptoms, any major knee injury, menisectomy, knee replacement surgery, age of surgery), HRT history, osteoporosis diagnosis.
  • OA e.g., knee, hips, hands and spine
  • date of primary diagnosis e.g., knee, hips, hands and spine
  • knee history current symptoms, any major knee injury, menisectomy, knee replacement surgery, age of surgery
  • HRT history osteoporosis diagnosis.
  • polymorphic site refers to a region in a nucleic acid at which two or more alternative nucleotide sequences are observed in a significant number of nucleic acid samples from a population of individuals.
  • a polymorphic site may be a nucleotide sequence of two or more nucleotides, an inserted nucleotide or nucleotide sequence, a deleted nucleotide or nucleotide sequence, or a microsatellite, for example.
  • a polymorphic site that is two or more nucleotides in length may be 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or more, 20 or more, 30 or more, 50 or more, 75 or more, 100 or more, 500 or more, or about 1000 nucleotides in length, where all or some of the nucleotide sequences differ within the region.
  • a polymorphic site is often one nucleotide in length, which is referred to herein as a "single nucleotide polymorphism” or a "SNP.”
  • each nucleotide sequence is referred to as a "polymorphic variant” or "nucleic acid variant.”
  • the polymorphic variant represented in a minority of samples from a population is sometimes referred to as a "minor allele” and the polymorphic variant that is more prevalently represented is sometimes referred to as a "major allele.”
  • genotyped refers to a process for determining a genotype of one or more individuals, where a "genotype” is a representation of one or more polymorphic variants in a population.
  • a genotype or polymorphic variant may be expressed in terms of a "haplotype,” which as used herein refers to two or more polymorphic variants occurring within genomic DNA in a group of individuals within a population. For example, two SNPs may exist within a gene where each SNP position includes a cytosine variation and an adenine variation.
  • Certain individuals in a population may carry one allele (heterozygous) or two alleles (homozygous) having the gene with a cytosine at each SNP position.
  • the individuals can be characterized as having a cytosine/cytosine haplotype with respect to the two SNPs in the gene.
  • phenotype refers to a trait which can be compared between individuals, such as presence or absence of a condition, a visually observable difference in appearance between individuals, metabolic variations, physiological variations, variations in the function of biological molecules, and the like.
  • a phenotype is occurrence of osteoarthritis.
  • a polymorphic variant is statistically significant and often biologically relevant if it is represented in 5% or more of a population, sometimes 10%) or more, 15% or more, or 20% or more of a population, and often 25% or more, 30% or more, 35% or more, 40% or more, 45% or more, or 50% or more of a population.
  • a polymorphic variant may be detected on either or both strands of a double-stranded nucleic acid.
  • a polymorphic variant may be located within an intron or exon of a gene or within a portion of a regulatory region such as a promoter, a 5' untranslated region (UTR), a 3' UTR, and in DNA (e.g., genomic DNA (gDNA) and complementary DNA (cDNA)), RNA (e.g., mRNA, tRNA, and rRNA), or a polypeptide.
  • DNA e.g., genomic DNA (gDNA) and complementary DNA (cDNA)
  • RNA e.g., mRNA, tRNA, and rRNA
  • Polymorphic variations may or may not result in detectable differences in gene expression, polypeptide structure, or polypeptide function.
  • polymorphic variants at positions rs910223, rs 1367117, rs 1024791, rs 1041973, rsl465621, rs398829, rsl018810, rsl484086, rs242392, rs8818, rsl395486, rs512294 and/or rsl32659 in the human genome were associated with an increased risk of osteoarthritis, and in specific embodiments, the corresponding allele in the right-most column in Table B for each position is associated with an increased risk of osteoarthritis.
  • polymorphic variants at positions rsl367117, rsl041973 and rs398829 were associated with an increased risk of osteoarthritis, and in specific embodiments, a threonine encoded by rs 1367117, an alanine encoded by rs 1041973, and a valine encoded by rs398829 were associated with an increased risk of osteoartliritis.
  • Polymorphic variants in and around the APOB locus were tested for association with osteoarthritis.
  • polymorphic variants at positions in SEQ ID NO: 2 selected from the group consisting of 238, 294, 295, 347, 1425, 4891, 5087, 7041, 7121, 7219, 7443, 7485, 10939, 11367, 11571, 11839, 12551, 12646, 13469, 14913, 15205, 15246, 15695, 17473, 17610, 17828, 18130, 18281, 18623, 18890, 21561, 23100, 23872, 24581, 24582, 24983, 27540, 30846, 31415, 31453, 31899, 37000, 38681, 39287, 42951, 45648, 46222, 46687, 47020, 47593, 48513, 49723, 49986, 53018, 53296, 53547, 53899, 53916, 53933, 54305, 55327, 55895, 56143, 56640, 58486, 59576, 530
  • Polymorphic variants at the following positions in SEQ ID NO: 2 in particular were associated with an increased risk of osteoarthritis: 7219, 7485, 11839, 31899, 37000, 48513, 49986, 56640, 74407, 77398, 93060 and 97627.
  • polymorphic variants in SEQ ID NO: 2 were associated with risk of osteoarthritis: an adenine at position 7219, a guanine at position 7485, an adenine at position 11839, a thymine at position 31899, an adenine at position 37000, a cytosine at position 48513, a guanine at position 49986, a guanine at position 56640, a cytosine at position 74407, a guanine at position 77398, an adenine at position 93060 and an adenine at position 97627.
  • a threonine at amino acid position 98 in an APOB polypeptide was associated with increased risk of osteoarthritis (i.e., an isoleucine to threonine non-synonymous variation).
  • Polymorphic variants in and around the IL1RL2 locus were tested for association with osteoarthritis.
  • polymorphic variants at positions in SEQ ID NO: 3 selected from the group consisting of 225, 509, 860, 874, 939, 1483, 1798, 2189, 2215, 2282, 2340, 2963, 3369, 3481, 3564, 3653, 4860, 4941, 4975, 5321, 5346, 5541, 5633, 6007, 6317, 6378, 6382, 6426, 6479, 6641, 6703, 6705, 7963, 8525, 8526, 8598, 8624, 8883, 8980, 13578, 16135, 16141, 16642, 16931, 17004, 17009, 17010, 18713, 18853, 20783, 21335, 22180, 22268, 22285, 25378, 25906, 26015, 26475, 26798 :
  • Polymorphic variants at the following positions in SEQ ID NO: 3 in particular were associated with an increased risk of osteoarthritis: 2215, 3369, 16642, 20783, 52155, 55052, 55941, 74333, 74741, 85366, 85469, 87687, 89660 and 95718, where specific embodiments are directed to position 52155.
  • polymorphic variants in SEQ ID NO: 3 were associated with risk of osteoarthritis: an adenine at position 2215, a deletion at position 3369, a deletion at position 16642, a cytosine at position 20783, a cytosine at position 52155, a cytosine at position 55052, a cytosine at position 55941, a thymine at position 74333, an adenine at position 74741, a deletion at position 85366, a thymine at position 85469, a thymine at position 87687, an adenine at position 89660 and a cytosine at position 95718.
  • Polymorphic variants in and around the ILIRLI locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 4 selected from the group consisting of 207, 6019, 6414, 7341, 10984, 12351, 13335, 16584, 16737, 23897, 24057, 25145, 25300, 26262, 26312, 26589, 27302, 27358, 27451, 27552, 30731, 32085, 32139, 33184, 42382, 42569, 44823, 45217, 45548, 45601, 45722, 45967 ,47367, 47642, 48126, 49218, 49274, 49433, 49610, 51282, 51466, 53757, 53960, 54031, 54574, 55679, 56100, 56182, 59817, 60533, 60656, 72209, 72778, 74293, 77335, 78029, 78374, 7
  • Polymorphic variants at the following positions in SEQ ID NO: 4 in particular were associated with an increased risk of osteoarthritis: 6414, 51282, 54574, 78374, 92029 and 96793, where specific embodiments are directed to position 54574.
  • the following polymorphic variants in SEQ ID NO: 4 were associated with risk of osteoarthritis: an adenine at position 6414, an adenine at positoin 51282, a cytosine at position 54574, a thymine at position 92029 and an adenine at position 96793.
  • Polymorphic variants in and around the WASPIP locus were tested for association with osteoarthritis.
  • polymorphic variants at positions in SEQ ID NO: 5 selected from the group consisting of 209, 5908, 7460, 7733, 7855, 7904, 8869, 9480, 13820, 15152, 17713, 17804, 18220, 19083, 19123, 19605, 20247, 20592, 21907, 23273, 23299, 23623, 23669, 23844, 24190, 24486, 24896, 25118, 30551, 30844, 30900, 30942, 31699, 32081, 35078, 36196, 36541, 38356, 45578, 49634, 49774, 51119, 51181, 51652, 54467, 55762, 55999, 57865, 66613, 68377, 69754, 72859, 76512, 76717, 77722, 80998, 82033, 89658, 89960, 94155 and 95679.
  • Polymorphic variants at the following positions in SEQ ID NO: 5 in particular were associated with an increased risk of osteoarthritis: 19083, 30900, 38356, 76512 and 94155, where specific embodiments are directed to positions 30900, 76512 and/or 94155.
  • the following polymorphic variants in SEQ ID NO: 5 were associated with risk of osteoarthritis: a thymine at position 19083, a guanine at position 30900, an adenine at position 38356, an adenine at position 76512 and an adenine at position 94155.
  • Polymorphic variants in and around the ADAMTS2 locus were tested for association with osteoarthritis.
  • polymorphic variants at positions in SEQ ID NO: 6 selected from the group consisting of 210, 3608, 3609, 4318, 5593, 5629, 5639, 5640, 8943, 17968, 19887, 21034, 21085, , 21596, 23379, 23432, 24007, 26121, 26273, 26755, 27411, 27710, 27842, 28379, 29603, 31232, 31504, 32583, 32794, 32840, 33044, 33150, 33218, 33513, 33959, 34486, 36289, 36570, 38247, 38477, 38518, 38529, 38667, 39781, 39856, 39927, 40506, 41869, 42452, 44788, 46059, 46846, 47712, 48796, 49441, 49602, 49723, 50050, 50171, 50477, 50818, 50833, 50881, 50882, 51386, 51534, 523
  • Polymorphic variants at the following positions in SEQ ID NO: 6 in particular were associated with an increased risk of osteoarthritis: 5640, 33150, 38247, 38529, 46846, 49723, 50050, 63427, 73889, 189104 and rs428901, where specific embodiments are directed to positions 46846, 73889, 189104 and/or rs428901.
  • polymorphic variants in SEQ ID NO: 6 were associated with risk of osteoarthritis: a cytosine at position 5640, a cytosine at position 33150, an adenine at position 38247, a thymine at position 38529, an adenine at position 46846, a cytosine at position 49723, a cytosine at position 50050, a cytosine a position 63427, a guanine at position 73889, a thymine at position 189104, and an adenine at position rs428901. [0030] Polymorphic variants in and around the BVES locus were tested for association with osteoarthritis.
  • polymorphic variants at positions in SEQ ID NO: 7 selected from the group consisting of 241, 801, 899, 2091, 2290, 2440, 4959, 7914, 7969, 7972, 10831, 12399, 13841, 14461, 14680, 16808, 18231, 18394, 18505, 18684, 19257, 20263, 20656, 21499, 21563, 21612, 21834, 22406, 22408, 22685, 23303, 23306, 25139, 25211, 25364, 25381, 25414, 25835, 26214, 27224, 27526, 27934, 28550, 29015, 29879, 29979, 30030, 30585, 31753, 31934, 33227, 33228, 35172, 36901, 36921, 36932, 37061, 37570, 38745, 38970, 39725, 40070, 40460, 41470, 41562, 41956, 42047, 42
  • Polymorphic variants at the following positions in SEQ ID NO: 7 in particular were associated with an increased risk of osteoarthritis: 25414, 25835, 38970, 41470, 44115, 47496, 49038, 50204, 50840, 50964, 50971, 53906, 54149, 58415, 70796, 72325, 75258, 77822, 80002, 85288, 85581, 86904, 90828, 94616, 94712, 95869 and 97856.
  • polymorphic variants in SEQ ED NO: 7 were associated with risk of osteoarthritis: an adenine at position 25414, a cytosine at position 25835, an adenine at position 38970, an adenine at position 41470, an adenine at position 44115, a guanine at position 47496, a cytosine at position 49038, an adenine at position 50204, a thymine at position 50840, a cytosine at position 50964, a cytosine at position 50971, an adenine at position 53906, a guanine at position 54149, a.
  • guanine at position 58415 a thymine at position 70796, a guanine at position 72325, a cytosine at position 75258, an adenine at position 77822, an adenine at position 80002, an adenine at position 85288, an adenine at position 85581, a guanine at position 86904, a guanine at position 90828, an adenine thymine adenine adenine sequence at position 94616, a cytosine at position 94712, a guanine at position 95869 and a cytosine at position 97856.
  • Polymorphic variants in and around the TM7SF3 locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 8 selected from the group consisting of 230, 231, 5330, 6334, 11372, 11456, 11501, 13393, 16666, 17596, 19710, 19800, 20297, 20967, 32514, 33159, 37600, 41259, 41329, 50060, 53292, 53393, 56417, 56435, 58847, 59595, 59661, 60355, 60407, 62357, 68230, 68516, 69055, 72603, 73928, 85897 and 91554.
  • Polymorphic variants at the following positions in SEQ ID NO: 8 in particular were associated with an increased risk of osteoarthritis: 56435, 59595, 53292, 33159 and 41329, with specific embodiments directed to positions 56435 and/or 59595.
  • the following polymorphic variants in SEQ ID NO: 8 were associated with risk of osteoarthritis: a thymine thymine repeat at position 56435, a thymine at position 59595, a cytosine at position 53292, a guanine at position 33159 and a thymine at position 41329.
  • Polymorphic variants in and around the LOXLl locus were tested for association with osteoarthritis.
  • polymorphic variants at positions in SEQ ID NO: 10 selected from the group consisting of 213, 249, 1824, 2057, 23O6, 2869, 3976, 4288, 4290, 4434, 5298, 5467, 8486, 8487, 8831, 9036, 9058, 9131, 9732, 9862, 10191, 10270, 16167, 17620, 17751, 17764, 17787, 19401 , 21021, 21902, 22173, 22416, 22653, 24945, 25011, 28563, 48574, 48710, 48880, 50194, 56343, 56455, 56729, 56759, 56895, 57036, 57702, 62515, 62629, 63501, 63547, 64876, 65073, 67149, 67549, 71660, 71906 and 71911.
  • Polymorphic variants in and around the CASPR4 locus were tested for association with osteoarthritis.
  • polymorphic variants at positions in SEQ ID NO: 11 selected from the group consisting of 205, 866, 4212, 5934, 11486, 16969, 22509, 22796, 28097, 28626, 28853, 28873, 30155, 30827, 31956, 32404, 32944, 35205, 35227, 35781, 41052, 45051, 46039, 47276, 47678, 47716, 51014, 54408, 54596, 56853, 61851, 62016, 62461, 68257, 69793, 73976, 73999, 74053, 75315, 75729, 76466, 77216, 77217, 79239, 80825, 81060, S1097, 81426, 84787, 84896, 85165, 86502, 86753, 86941, 88787 and 95598.
  • Polymorphic variants at tire following positions in SEQ ID NO: 11 in particular were associated with an increased risk of osteoarthritis: 47716 and 69793.
  • the following polymorphic variants in SEQ ID NO: 11 were associated with risk of osteoarthritis: an adenine at position 47716 and a thymine at position 69793.
  • Polymorphic variants in and around the APOL3 locus were tested for association with osteoarthritis.
  • polymorphic variants at positions in SEQ ID NO: 13 selected from the group consisting of 201, 425, 1095, 2201, 7879, 8395, 8461, 9503, 10304, 10695, 16300, 16444, 17591, 17988, 19116, 19358, 20300, 20669, 20891, 21451, 21978, 22785, 24248, 24770, 24844, 25066, 25096, 25309, 25344, 25529, 25537, 25554, 27963, 28134, 28356, 29648, 29986, 30217, 30267, 30315, 30585, 30724, 30897, 30931, 31080, 31246, 31373, 31463, 31467, 32188, 32288, 32520, 32594, 32657, 32677, 32764, 32784, 32830, 32872, 33121, 33348, 33952, 34184, 34361, 35026, 35192, 35600, 36033
  • Polymorphic variants at the following positions in SEQ ID NO: 13 in particular were associated with an increased risk of osteoarthritis: 20300, 46257, 87958, 89236, 30267, 32657, 36289, 38869, 45051, 54112, 60307, 63499, 20891, 52699, 71768, with specific embodiments directed to position 46257.
  • polymorphic variants in SEQ ID NO: 13 were associated with risk of osteoarthritis: an adenine at position 20300, a thymine at position 46257, an adenine at position 89236, a guanine at position 30267, an adenine at position 32657, a cytosine at position 36289, a guanine at position 38869, a thymine at position 45051, a guanine at position 54112, an adenine at position 60307, a thymine at position 63499, a guanine at position 20891, a guanine at position 52699, and a cytosine at position 71768.
  • polymorphic variants in a region spanning positions 21233000 to 21243000 (approximately 10,000 nucleotides in length) in a APOB locus a region spanning chromosome positions 102456500 to 102471500 (approximately 15,000 nucleotides in length) in a IL1RL2 locus, a region spanning chromosome positions 102570000 to 102583000 (approximately 13,000 nucleotides in length) in a ILIRLI locus, a region spanning chromosome positions 175647734 to 175655734 (approximately 8,000 nucleotides in length) in a WASPIP locus, a region spanning chromosome positions 178746000 to 178751000 (approximately 5,000 nucleotides in length) in a ADAMTS2 locus, a region spanning chromosome positions 105595000 to 105615000 (approximately
  • a method for identifying polymorphic variants proximal to an incident, founder polymorphic variant associated with osteoarthritis comprises identifying a polymorphic variant proximal to the incident polymorphic variant associated with osteoarthritis, where the incident polymorphic variant is in a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B.
  • the nucleotide sequence often comprises a polynucleotide sequence selected from the group consisting of (a) a polynucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (b) a polynucleotide sequence that encodes a polypeptide having an amino acid sequence encoded by a polynucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; and (c) a polynucleotide sequence that encodes a polypeptide having an amino acid sequence that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B or a polynucleotide sequence 90% or more identical to the polynucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B.
  • the presence or absence of an association of the proximal polymorphic variant with osteoarthritis then is determined using a known association method, such as a method described in the Examples hereafter.
  • the incident polymorphic variant is a polymorphic variant associated with osteoarthritis described herein.
  • the proximal polymorphic variant identified sometimes is a publicly disclosed polymorphic variant, which for example, sometimes is published in a publicly available database.
  • the polymorphic variant identified is not publicly disclosed and is discovered using a known method, including, but not limited to, sequencing a region surrounding the incident polymorphic variant in a group of nucleic samples.
  • a known association method such as a method described in the Examples hereafter.
  • the incident polymorphic variant is a polymorphic variant associated with osteoarthritis described herein.
  • the proximal polymorphic variant identified sometimes is a publicly disclosed polymorphic variant, which for example, sometimes is published in a publicly available database.
  • the polymorphic variant identified is not publicly disclosed and is discovered using a
  • the proximal polymorphic variant often is identified in a region surrounding the incident polymorphic variant.
  • this surrounding region is about 50 kb flanking the first polymorphic variant (e.g. about 50 kb 5' of the first polymorphic variant and about 50 kb 3' of the first polymorphic variant), and the region sometimes is composed of shorter flanking sequences, sxich as flanking sequences of about 40 kb, about 30 kb, about 25 kb, about 20 kb, about 15 kb, about 10 kb, about 7 kb, about 5 kb, or about 2 kb 5' and 3' of the incident polymorphic variant.
  • the region is composed of longer flanking sequences, such as flanking sequences of about 55 kb, about 60 kb, about 65 kb, about 70 kb, about 75 kb, about 80 kb, about 85 kb, about 9O kb, about 95 kb, or about 100 kb 5' and 3' of the incident polymorphic variant.
  • flanking sequences of about 55 kb, about 60 kb, about 65 kb, about 70 kb, about 75 kb, about 80 kb, about 85 kb, about 9O kb, about 95 kb, or about 100 kb 5' and 3' of the incident polymorphic variant.
  • polymorphic variants associated with osteoarthritis are identified iteratively.
  • a first proximal polymorphic variant is associated with osteoarthritis using the methods described above and then another polymorphic variant proximal to the first proximal polymorphic variant is identified (e.g., publicly disclosed or discovered) and the presence or absence of an association of one or more other polymorphic variants proximal to the first proximal polymorphic variant with osteoarthritis is determined.
  • the methods described herein are useful for identifying or discovering additional polymorphic variants that may be used to further characterize a gene, region or loci associated with a condition, a disease (e.g., osteoarthritis), or a disorder.
  • allelotyping or genotyping data from the additional polymorphic variants may be used to identify a functional mutation or a region of linkage disequilibrium.
  • polymorphic variants identified or discovered within a region comprising the first polymorphic variant associated with osteoarthritis are genotyped using the genetic methods and sample selection techniques described herein, and it can be determined whether those polymorphic variants are in linkage disequilibrium with the first polymorphic variant. The size of the region in linkage disequilibrium with the first polymorphic variant also can be assessed using these genotyping methods.
  • methods for determining whether a polymorphic variant is in linkage disequilibrium with a first polymorphic variant associated with osteoarthritis and such information can be used in prognosis/diagnosis methods described herein.
  • Isolated Nucleic Acids Featured herein are isolated PAJ I2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid variants depicted in SEQ ID NO: 1-13, SEQ ID NO: 14-36 or referenced in Table B, and substantially identical nucleic acids thereof.
  • a nucleic acid variant may be represented on one or both strands in a double-stranded nucleic acid or on one chromosomal complement (heterozygous) or both chromosomal complements (homozygous).
  • ADAMTS2 exists in two forms, a "long” form comprising a molecule approximately 130 kDa in length (e.g., SEQ ID NO: 21 for cDNA sequence and SEQ ID NO: 44 for amino acid sequence), and a "short” form comprising a molecule approximately 70 kDa in length (e.g., SEQ ID NO: 22 for cDNA sequence and SEQ ID NO: 45 for amino acid sequence).
  • a "long” form comprising a molecule approximately 130 kDa in length
  • SEQ ID NO: 44 for amino acid sequence
  • short comprising a molecule approximately 70 kDa in length
  • nucleic acid includes DNA molecules (e.g., a complementary DNA (cDNA) and genomic DNA (gDNA)) and RNA molecules (e.g., mRNA, rRNA, siRNA and tRNA) and analogs of DNA or RNA, for ex-ample, by use of nucleotide analogs.
  • the nucleic acid molecule can be single-stranded and it is often double-stranded.
  • isolated or purified nucleic acid refers to nucleic acids that are separated from other nucleic acids present in the natural source of the nucleic acid.
  • isolated includes nucleic acids which are separated from the chromosome with which the genomic DNA is naturally associated.
  • An "isolated” nucleic acid is often free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5' and/or 3' ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived.
  • the isolated nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 -b, 0.5 kb or 0.1 kb of 5' and/or 3' nucleotide sequences which flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived.
  • an "isolated" nucleic acid molecule such as a cDNA molecule, can be substantially free of other cellular material, or culture medium, when produced by recombinant techniques, or substantially free of chemical precursors or other chemicals when chemically synthesized.
  • nucleic acid fragments As used herein, the term “gene” refers to a nucleotide sequence that encodes a polypeptide. [0043] Also included herein are nucleic acid fragments. These fragments often have a nucleotide sequence identical to a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, a nucleotide sequence substantially identical to a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, or a nucleotide sequence that is complementary to the foregoing.
  • the nucleic acid fragment may be identical, substantially identical or homologous to a nucleotide sequence in an exon or an intron in a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, and may encode a domain or part of a domain of a polypeptide. Sometimes, the fragment will comprises one or more of the polymorphic variations described herein as being associated w th osteoarthritis.
  • the nucleic acid fragment is often 50, 100, or 200 or fewer base pairs in length, and is sometimes about 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500, 2000, 3000, 4000, 5000, 10000, 15000, or 20000 base pairs in length.
  • a nucleic acid fragment that is complementary to a. nucleotide sequence identical or substantially identical to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B and hybridizes to such a nucleotide sequence under stringent conditions is often referred to as a "probe.”
  • Nucleic acid fragments often include one or more polymorphic sites, or sometimes have an end that is adjacent to a polymo ⁇ hic site as described hereafter.
  • An example of a nucleic acid fragment is an oligonucleotide.
  • oligonucleotide refers to a nucleic acid comprising about 8 to about 50 covalently linked nucleotides, often comprising from about 8 to about 35 nucleotides, and more often from about 10 to about 25 nucleotides.
  • the backbone and nucleotides within an oligonucleotide may be the same as those of naturally occurring nucleic acids, or analogs or derivatives of naturally occurring nucleic acids, provided that oligonucleotides having such analogs or derivatives retain the ability to hybridize specifically to a nucleic acid comprising a targeted polymorphism.
  • Oligonucleotides described herein may be used as hybridization probes or as components of prognostic or diagnostic assays, for example, as described herein.
  • Oligonucleotides are typically synthesized using standard methods and equipment, such as the ABITM3900 High Throughput DNA Synthesizer and the EXPEDITETM 8909 Nucleic Acid Synthesizer, both of which are available from Applied Biosystems (Foster City, CA). Analogs and derivatives are exemplified in U.S. Pat. Nos.
  • Oligonucleotides may also be linked to a second moiety.
  • the second moiety may be an additional nucleotide sequence such as a tail sequence (e.g., a polyadenosine tail), an adapter sequence (e.g., phage Ml 3 universal tail sequence), and others.
  • the second moiety may be a non- nucleotide moiety such as a moiety which facilitates linkage to a solid support or a label to facilitate detection of the oligonucleotide.
  • Such labels include, without limitation, a radioactive label, a fluorescent label, a chemiluminescent label, a paramagnetic label, and the like.
  • the second moiety may be attached to any position of the oligonucleotide, provided the oligonucleotide can hybridize to the nucleic acid comprising the polymorphism.
  • Nucleic acid coding sequences may be used for diagnostic purposes for detection and control of polypeptide expression. Also, included herein are oligonucleotide sequences such as antisense RNA, small-interfering RNA (siRNA) and DNA molecules and ribozymes that function to inhibit translation of a polypeptide. Antisense techniques and RNA interference techniques are known in the art and are described herein. [0048] Ribozymes are enzymatic RNA molecules capable of catalyzing the specific cleavage of RNA. The mechanism of ribozyme action involves sequence specific hybridization of the ribozyme molecule to complementary target RNA, followed by endonucleolytic cleavage.
  • hammerhead motif ribozyme molecules may be engineered that specifically and efficiently catalyze endonucleolytic cleavage of RNA sequences corresponding to or complementary to PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequences or other nucleotide sequences referenced in Table B.
  • Specific ribozyme cleavage sites within any potential RNA target are initially identified by scanning the target molecule for ribozyme cleavage sites which include the following sequences, GUA, GUU and GUC.
  • RNA sequences of between fifteen (15) and twenty (20) ribonucleotides corresponding to the region of the target gene containing the cleavage site may be evaluated for predicte d structural features such as secondary structure that may render the oligonucleotide sequence unsuitable.
  • the suitability of candidate targets may also be evaluated by testing their accessibility to hybridization with complementary oligonucleotides, using ribonuclease protection assays.
  • Antisense RNA and DNA molecules, siRNA and ribozymes may be prepared by any method known in the art for the synthesis of RNA molecules.
  • RNA molecules may be generated by in vitro and in vivo transcription of DNA sequences encoding the antisense RNA molecule.
  • DNA sequences may be incorporated into a wide variety of vectors which incorporate suitable RNA polymerase promoters such as the T7 or SP6 polymerase promoters.
  • antisense cDNA constructs that synthesize antisense RNA constitutively or inducibly, depending on the promoter used, can be introduced stably into cell lines.
  • DNA encoding a polypeptide also may have a number of uses for the diagnosis of diseases, including osteoarthritis, resulting from aberrant expression of a target gene described herein.
  • the nucleic acid sequence may be used in hybridization as. says of biopsies or autopsies to diagnose abnormalities of expression or function (e.g., Southern or ' Northern blot analysis, in situ hybridization assays).
  • the expression of a polypeptide during embryonic development may also be determined using nucleic acid encoding the polypeptide. As addressed, infra, production of functionally impaired polypeptide is the cause of various disease states, such as osteoarthritis.
  • In situ hybridizations using polypeptide as a probe may be employed to predict problems related to osteoarthritis. Further, as indicated, infra, administration of human active polypeptide, recom-binantly produced as described herein, may be used to treat disease states related to functionally impaired polypeptide. Alternatively, gene therapy approaches may be employed to remedy deficiencies of functional polypeptide or to replace or compete with dysfunctional polypeptide.
  • nucleic acid vectors are provided herein, which contain a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a sxxbstantially identical sequence thereof.
  • vector refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked and can include a p lasmid, cosmid, or viral vector.
  • the vector can be capable of autonomous replication or it can integrate into a host DNA.
  • Viral vectors may include replication defective retroviruses, adenoviruses and adeno-associated viruses for example.
  • a vector can include a PADI2, APOB, IL1RL2, ILIRLI , WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B in a form suitable for expression of an encoded target polypeptide or target nucleic acid in a host cell.
  • a “target polypeptide” is a polypeptide encoded by aPA2 I2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a substantially identical nucleotide sequence thereof.
  • the recombinant expression vector typically includes one or more regulatory sequences operatively linked to the nucleic acid sequence to be expressed.
  • the term “regulatory sequence” includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals).
  • Regulatory sequences include those that direct constitutive expression of a nucleotide sequence, as well as tissue-specific regulatory and/or inducible sequences.
  • the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of polypeptide desired, and the like.
  • Expression vectors can be introduced into host cells to produce target polypeptides, including fusion polypeptides.
  • Recombinant expression vectors can be designed for expression of target polypeptides in prokaryotic or eukaryotic cells.
  • target polypeptides can be expressed in E. coli, insect cells (e.g., using baculovirus expression vectors), yeast cells, or mammalian cells.
  • the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.
  • T7 promoter regulatory sequences and T7 polymerase for example, T7 promoter regulatory sequences and T7 polymerase.
  • Fusion vectors add a number of amino acids to a polypeptide encoded therein, usually to the amino terminus of the recombinant polypeptide.
  • Such fusion vectors typically serve three pu ⁇ oses: 1) to increase expression of recombinant polypeptide; 2) to increase the solubility of the recombinant polypeptide; and 3) to aid in the purification of the recombinant polypeptide by acting as a ligand in affinity purification.
  • a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant polypeptide to enable separation of the recombinant polypeptide from the fusion moiety subsequent to purification of the fusion polypeptide.
  • enzymes, and their cognate recognition sequences include Factor Xa, thrombin and enterokinase.
  • Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith & Johnson, Gene 67: 31-40 (1988)), pMAL (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) which fuse glutathione S- transferase (GST), maltose E binding polypeptide, or polypeptide A, respectively, to the target recombinant polypeptide.
  • GST glutathione S- transferase
  • MST glutathione S- transferase
  • maltose E binding polypeptide or polypeptide A, respectively, to the target recombinant polypeptide.
  • Purified fusion polypeptides can be used in screening assays and to generate antibodies specific for target polypeptides.
  • fusion polypeptide expressed in a refroviral expression vector is used to infect bone marrow cells that are subsequently transplanted into irradiated recipients. The pathology of the subject recipient is then examined after sufficient time has passed (e.g., six (6) weeks). [0057] Expressing the polypeptide in host bacteria with an impaired capacity to proteolytically cleave the recombinant polypeptide is often used to maximize recombinant polypeptide expression (Gottesman, S., Gene Expression Technology: Methods in Enzymology, Academic Presrs, San Diego, California 185: 119-128 (1990)).
  • Another strategy is to alter the nucleotide sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in E. coli (Wada et al, Nucleic Acids Res. 20: 2111-2118 (1992)). Such alteration of nucleotide sequences can be carried out by standard DNA synthesis techniques.
  • the expression vector's control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40.
  • Recombinant mammalian expression vectors are often capable of directing expression of the nucleic acid in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid).
  • tissue-specific regulatory elements include an albumin promoter (liver-specific; Pinkert et al, Genes De ⁇ v. 1: 268-277 (1987)), lymphoid-specific promoters (Calame & Eaton, Adv. Immunol 43: 235-275 (1 -988)), promoters of T cell receptors (Winoto & Baltimore, EMBOJ.
  • promoters of immunoglobulins (Banerji et al, Cell 33: 129-140 (1983); Queen & Baltimore, Cell 33s 741-748 (1983)), neuron-specific promoters (e.g., the neurofilament promoter; Byrne & Ruddle, Proc. Natl. Acad. Sci. USA 86: 5473-5477 (1989)), pancreas-specific promoters (Edlund et al, Science 230: 912- 916 (1985)), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Patent No. 4,873,316 and European Application Publication No. 264,166).
  • immunoglobulins (Banerji et al, Cell 33: 129-140 (1983); Queen & Baltimore, Cell 33s 741-748 (1983)
  • neuron-specific promoters e.g., the neurofilament promoter; Byrne & Ruddle,
  • a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, Z OXL1, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B also may be cloned into an expression vector in an antisense orientation.
  • Antisense expression vectors can be in the form of a recombinant plasmid, phagemid or attenuated virus.
  • host cells that include a PADI2, APOB, IL1RL2, IIL1RL1, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B within a recombinant expression vector or a fragment of such a nucleotide sequence which facilitate homologous recombination into a specific site of the host cell genome.
  • the terms "host cell” and "recombinant host cell” are used interchangeably herein. Such terms refer not only to the particular subject cell but rather also to the progeny or potential progeny of such a cell.
  • a host cell can be any prokaryotic or eukaryotic cell.
  • a target polypeptide can be expressed in bacterial cells such as E. coli, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art.
  • Vectors can be introduced into host cells via conventional transformation or transfection techniques.
  • transformation and “transfection” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, transduction/infection, DEAE- dextran-mediated transfection, lipofection, or electroporation.
  • a host cell provided herein can be used to produce (i.e., express) a target polypeptide or a substantially identical polypeptide thereof. Accordingly, further provided are methods for producing a target polypeptide using host cells described herein.
  • the method includes culturing host cells into which a recombinant expression vector encoding a target polypeptide has been introduced in a suitable medium such that a target polypeptide is produced.
  • the metiiod further includes isolating a target polypeptide from the medium or the host cell.
  • cells or purified preparations of cells which include a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 transgene, or other transgene in Table B, or which otherwise misexpress target polypeptide.
  • Cell preparations can consist of human or non-human cells, e.g., rodent cells, e.g., mouse or rat cells, rabbit cells, or pig cells.
  • the cell or cells include a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 transgene or other transgene referenced in Table B (e.g., a heterologous form of & PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 gene or other gene referenced in Table B, such as a human gene expressed in non-human cells).
  • the transgene can be misexpressed, e.g., overexpressed or underexpressed.
  • the cell or cells include a gene which misexpress an endogenous target polypeptide (e.g., expression of a gene is disrupted, also known as a knockouf .
  • Such cells can serve as a model for studying disorders which are related to mutated or mis-expressed alleles or for use in drug screening.
  • human cells e.g., a hematopoietic stem cells
  • cells or a purified preparation thereof e.g.
  • an endogenous PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B is under the control of a regulatory sequence that does not normally control the expression of the endogenous gene.
  • the expression characteristics of an endogenous gene within a cell e.g., a cell line or microorganism
  • an endogenous corresponding gene e.g., a gene which is "transcriptionally silent,” not normally expressed, or expressed only at very low levels
  • a regulatory element which is capable of promoting the expression of a normally expressed gene product in that cell.
  • Techniques such as targeted homologous recombinations, can be used to insert the heterologous DNA as described in, e.g., Chappel, US 5,272,071; WO 91/06667, published on May 16, 1991.
  • Non-human transgenic animals that express a heterologous target polypeptide e.g., expressed from a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B, or substantially identical sequence thereof
  • a heterologous target polypeptide e.g., expressed from a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B, or substantially identical sequence thereof
  • Such animals are useful for studying the function and/or activity of a target polypeptide and for identifying and/or evaluating modulators of the activity of PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acids, other nucleic acids referenced in Table B, and encoded polypeptides.
  • a "transgenic animal” is a non-human animal such as a mammal (e.g., a non-human primate such as chimpanzee, baboon, or macaque; an ungulate such as an equine, bovine, or caprine; or a rodent such as a rat, a mouse, or an Israeli sand rat), a bird (e.g., a chicken or a turkey), an amphibian (e.g., a frog, salamander, or newt), or an insect (e.g., Drosophil ⁇ mel ⁇ nog ⁇ ster), in which one or more of the cells of the animal includes a transgene.
  • a mammal e.g., a non-human primate such as chimpanzee, baboon, or macaque
  • an ungulate such as an equine, bovine, or caprine
  • a rodent such as a rat, a mouse, or an Israeli
  • a transgene is exogenous DNA or a rearrangement (e.g., a deletion of endogenous chromosomal DNA) that is often integrated into or occurs in the genome of cells in a transgenic animal.
  • a transgene can direct expression of an encoded gene product in one or more cell types or tissues of the transgenic animal, and other transgenes can reduce expression (e.g., a knockout).
  • a transgenic animal can be one in which an endogenous nucleic acid homologous to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal (e.g., an embryonic cell of the animal) prior to development of the animal.
  • Intronic sequences and polyadenylation signals can also be included in the transgene to increase expression efficiency of the transgene.
  • tissue-specific regulatory sequences can be operably linked to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B to direct expression of an encoded polypeptide to particular cells.
  • a transgenic founder animal can be identified based upon the presence of a PADU, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B in its genome and/or expression of encoded mRNA in tissues or cells of the animals.
  • a transgenic founder animal can then be used to breed additional animals carrying the transgene.
  • transgenic animals carrying a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B can further be bred to other transgenic animals carrying other transgenes.
  • Target polypeptides can be expressed in transgenic animals or plants by introducing, for example, a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B into the genome of an animal that encodes the target polypeptide.
  • the nucleic acid is placed under the control of a tissue specific promoter, e.g., a milk or egg specific promoter, and recovered from the milk or eggs produced by the animal. Also included is a population of cells from a transgenic animal.
  • Target Polypeptides which are encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or a nucleotide sequence referenced in Table B (e.g., SEQ ID NO: 14-36 or a sequence referenced in Table B), or a substantially identical nucleotide sequence thereof.
  • PADI2 PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or a nucleotide sequence referenced in Table B (e.g., SEQ ID NO: 14-36 or a sequence referenced in Table B), or a substantially identical nucleotide sequence thereof.
  • polypeptide examples include proteins and peptides.
  • An "isolated” or “purified” polypeptide or protein is substantially free of cellular material or other contaminating proteins from the cell or tissue source from which the protein is derived, or substantially free from chemical precursors or other chemicals when chemically synthesized.
  • the language "substantially free” means preparation of a target polypeptide having less than about 30%, 20%, 10% and more preferably 5% (by dry weight), of non-target polypeptide (also referred to herein as a "contaminating protein"), or of chemical precursors or non-target chemicals.
  • a target polypeptide or a biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, specifically, where culture medium represents less than about 20%, sometimes less than about 10%, and often less than about 5% of the volume of the polypeptide preparation.
  • target polypeptide preparations are sometimes 0.01 milligrams or more or 0.1 milligrams or more, and often 1.0 milligrams or more and 10 milligrams or more in dry weight.
  • the APOL3 polypeptide or polypeptide fragment has APOL3 biological activity, for example, apolipoprotein activity.
  • target polypeptide fragments may be a domain or part of a domain of a target polypeptide.
  • the polypeptide fragment may have increased, decreased or unexpected biological activity.
  • the polypeptide fragment is often 50 or fewer, 100 or fewer, or 200 or fewer amino acids in length, and is sometimes 300, 400, 500, 600, 700, or 900 or fewer amino acids in length.
  • the polypeptide fragment sometimes is amino acids 90-396 of SEQ ID NO: 53; amino acids 19-325 of SEQ ID NO: 54; or amino acids 1-196 of SEQ ID NO: 55. Shown in Table A below are examples of polypeptide fragments, where approximate amino acid positions are shown in parenthesis (e.g., a Pellino domain starts at about amino acid 3 and ends at about amino acid 412). Amino acid sequences can be accessed using information in Table B and in SEQ ID NO: 37-55. TABLE A
  • Interleukin 1 receptor-like 1 isoform 1 (SEQ ID NO: 40) is a member of the interleukin 1 receptor family with no known ligand (orphan receptor). ILIRLI exists in soluble (SEQ ID NO: 41-42) and transmembrane forms, suggesting that it may have ligand or ligand scavenging activity.
  • ILIRLI protein agents may be administered to treat or prevent the occurrence of OA.
  • ILIRLI protein agents include ILIRLI polypeptides or fragments thereof that have ILIRLI ligand activity (e.g., recombinant polypeptides of SEQ ID NO: 41-42).
  • ILIRLI protein agents include ILIRLI polypeptides or fragments thereof that have ILIRLI ligand scavenging activity (e.g., recombinant polypeptide of SEQ ID NO: 40).
  • Isolated ILIRLI polypeptides featured herein include the full-length polypeptide, the mature polypeptide (i.e., the polypeptide without the signal sequence MGFWILAILTILMYSTAA) or a polypeptide fragment containing a domain or part of a ILIRLI domain. The polypeptide fragment may have increased, decreased or unexpected biological activity.
  • ADAMTS2 polypeptides having an ADAMTS2 activity e.g., a zinc binding activity, a metalloprotease activity, a procollagen II processing or synthesis activity, or a collagen II synthesis activity in vitro or in vivo.
  • the polypeptides are ADAMTS2 proteins including at least one propeptide domain, at least one metalloproteinase domain, at least one disintegrin-like domain, at least one, two, three, and often four thrombospondin domains, and sometimes having a ADAMTS2 activity, e.g., aADAMTS2 activity as described herein.
  • ADAMTS2 polypeptides and fragments thereof often have biological activity, such as excising the N-propeptide of type II procollagens. Methods for monitoring and quantifying this biological activity are known (e.g., Colige et al., J. Biol. Chem. 270: 16724-16730 (1995)).
  • Human ADAMTS2 protein (SEQ ID NO: 44-45) includes a signal sequence of about 29 amino acids (from amino acid 1 to about amino acid 29 of SEQ ID NO: 44-45).
  • the ADAMTS2 protein without the signal sequence can be approximately 1182 amino acid residues in length (from about amino acid 30 to amino acid 1211 of SEQ ID NO: 44) or approximately 485 amino acid residues in length (from about amino acid 30 to amino acid 514 of SEQ ID NO: 45).
  • Human ADAMTS2 protein includes a "pro" region homologous to the reprolysin family propeptide, which is typically post- translationally cleaved upon conversion of the inactive (or pro-domain containing) protein to the catalytically active metalloprotease.
  • the prodomain region of human ADAMTS2 protein corresponds to about amino acids 30 to 251, 30 to 252, 30 to 253, 30 to 254, 30 to 255, 30 to 256, 30 to 257, 30 to 258 or 30 to 259 of SEQ ID NO: 44-45, where it is understood that the active form of ADAMTS2 does not contain the propeptide domain.
  • catalytically active mature protein can be approximately 960, 959, 958, 957, 956, 955, 954, 953 or 952 amino acids in length (from about amino acid 252, 253, 254, 255, 256, 257, 258, 259 or 260 to amino acid 1211 of SEQ ID NO: 44) or approximately 261, 260, 259, 258, 257,
  • Human ADAMTS2 contains the following regions or other structural features: a signal sequence at about amino acids 1-29 of SEQ ID NO: 44-45; a reprolysin family propeptide domain located at about amino acid residues 30 to 251, 30 to 252, 30 to 253, 30 to 254, 30 to 255, 30 to 256, 30 to 257, 30 to 258 or 30 to 259 of SEQ ID NO: 44-45; a zinc-metalloprotease catalytic domain at about amino acids 251 to 479, 252 to 479, 253 to 479, 254 to 479, 255 to 479, 256 to 479, 257 to 479, 258 to 479 or 259 to 479 of SEQ ID NO: 44-45; a disintegrin domain at about amino acids 480 to 560 of SEQ ID NO: 44; a cysteine-rich domain at about amino acids 618 to 722 of SEQ ID NO:
  • ADAMTS2 polypeptide fragments having activity are selected from amino acids 252-1211, 253-1211, 254-1211, 255-1211, 256-1211, 257-1211, 258-1211, 259-1211 or 260-1211 of SEQ ID NO: 4, where it is understood that the active form of ADAMTS2 does not contain the propeptide domain.
  • Substantially identical target polypeptides may depart from the amino acid sequences of target polypeptides in different manners.
  • conservative amino acid modifications may be introduced at one or more positions in the amino acid sequences of target polypeptides.
  • a "conservative amino acid substitution” is one in which the amino acid is replaced by another amino acid having a similar structure and/or chemical function. Families of amino acid residues having similar structures and functions are well known.
  • amino acids with basic side chains e.g., lysine, arginine, histidine
  • acidic side chains e.g., aspartic acid, glutamic acid
  • uncharged polar side chains e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine
  • nonpolar side chains e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan
  • beta-branched side chains e.g., threonine, valine, isoleucine
  • aromatic side chains e.g., tyrosine, phenylalanine, tryptophan, histidine
  • a "non- essential" amino acid is one that can be altered without abolishing or substantially altering the biological function of a target polypeptide, whereas altering an "essential” amino acid abolishes or substantially alters the biological function of a target polypeptide.
  • Amino acids that are conserved among target polypeptides are typically essential amino acids.
  • the polypeptide includes one or more non-synonymous polymorphic variants associated with osteoarthritis, as described above (e.g., a threonine encoded by rsl367117 in an APOB polypeptide).
  • target polypeptides may exist as chimeric or fusion polypeptides.
  • a target “chimeric polypeptide” or target “fusion polypeptide” includes a target polypeptide linked to a non-target polypeptide.
  • a “non-target polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a polypeptide which is not substantially identical to the target polypeptide, which includes, for example, a polypeptide that is different from the target polypeptide and derived from the same or a different organism.
  • the target polypeptide in the fusion polypeptide can correspond to an entire or nearly entire target polypeptide or a fragment thereof.
  • the non-target polypeptide can be fused to the N-terminus or C-terminus of the target polypeptide.
  • Fusion polypeptides can include a moiety having high affinity for a ligand.
  • the fusion polypeptide can be a GST-target fusion polypeptide in which the target sequences are fused to the C-terminus of the GST sequences, or a polyhistidine-target fusion polypeptide in which the target polypeptide is fused at the N- or C-terminus to a string of histidine residues.
  • Such fusion polypeptides can facilitate purification of recombinant target polypeptide.
  • Fusion moiety e.g., a GST polypeptide
  • a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B, or a substantially identical nucleotide sequence thereof can be cloned into an expression vector such that the fusion moiety is linked in-frame to the target polypeptide.
  • the fusion polypeptide can be a target polypeptide containing a heterologous signal sequence at its N-terminus.
  • expression, secretion, cellular internalization, and cellular localization of a target polypeptide can be increased through use of a heterologous signal sequence.
  • Fusion polypeptides can also include all or a part of a serum polypeptide (e.g., an IgG constant region or human serum albumin).
  • a serum polypeptide e.g., an IgG constant region or human serum albumin.
  • Target polypeptides can be incorporated into pharmaceutical compositions and administered to a subject in vivo. Administration of these target polypeptides can be used to affect the bioavailability of a substrate of the target polypeptide and may effectively increase target polypeptide biological activity in a cell.
  • Target fusion polypeptides may be useful therapeutically for the treatment of disorders caused by, for example, (i) aberrant modification or mutation of a gene encoding a target polypeptide; (ii) mis-regulation of the gene encoding the target polypeptide; and (iii) aberrant post- translational modification of a target polypeptide.
  • target polypeptides can be used as immunogens to produce anti-target antibodies in a subject, to purify target polypeptide ligands or binding partners, and in screening assays to identify molecules which inhibit or enhance the interaction of a target polypeptide with a substrate.
  • polypeptides can be chemically synthesized using techniques known in the art (See, e.g., Creighton, 1983 Proteins. New York, N.Y.: W. H. Freeman and Company; and Hunkapiller et al., (1984) Nature July 12 -18;310(5973):105-11).
  • a relative short fragment can be synthesized by use of a peptide synthesizer.
  • non-classical amino acids or chemical amino acid analogs can be introduced as a substitution or addition into the fragment sequence.
  • Non-classical amino acids include, but are not limited to, to the D-isomers of the common amino acids, 2,4-diaminobutyric acid, a-amino isobutyric acid, 4-aminobutyric acid, Abu, 2-amino butyric acid, g- Abu, e-Ahx, 6-amino hexanoic acid, Aib, 2-amino isobutyric acid, 3-amino propionic acid, ornithine, norleucine, norvaline, hydroxyproline, sarcosine, citrulline, homocitrulline, cysteic acid, t-butylglycine, t-butylalanine, phenylglycine, cyclohexylalanine, b-alanine, fluoroamino acids, designer amino acids such as b-methyl amino acids, Ca-methyl amino acids, Na-methyl amino acids, and amino acid analogs in general.
  • amino acid can be D (dextrorotary) or L (levorotary).
  • Polypeptides and polypeptide fragments sometimes are differentially modified during or after translation, e.g., by glycosylation, acetylation, phosphorylation, amidation, derivatization by known protecting/blocking groups, proteolytic cleavage, linkage to an antibody molecule or other cellular ligand, etc.
  • any of numerous chemical modifications may be carried out by known techniques, including but not limited, to specific chemical cleavage by cyanogen bromide, trypsin, chymotrypsin, papain, V8 protease, NaBH4; acetylation, formylation, oxidation, reduction; metabolic synthesis in the presence of tunicamycin; and the like.
  • Additional post-translational modifications include, for example, N-linked or O-linked carbohydrate chains, processing of N-terminal or C-terminal ends), attachment of chemical moieties to the amino acid backbone, chemical modifications of N-linked or O-linked carbohydrate chains, and addition or deletion of an N-terminal methionine residue as a result of prokaryotic host cell expression.
  • polypeptide fragments may also be modified with a detectable label, such as an enzymatic, fluorescent, isotopic or affinity label to allow for detection and isolation of the polypeptide.
  • a detectable label such as an enzymatic, fluorescent, isotopic or affinity label to allow for detection and isolation of the polypeptide.
  • chemically modified derivatives of polypeptides that can provide additional advantages such as increased solubility, stability and circulating time of the polypeptide, or decreased immunogenicity (see e.g., U.S. Pat. No: 4,179,337.
  • the chemical moieties for derivitization may be selected from water soluble polymers such as polyethylene glycol, ethylene glycol/propylene glycol copolymers, carboxymethylcellulose, dextran, polyvinyl alcohol and the like.
  • the polypeptides may be modified at random positions within the molecule, or at predetermined positions within the molecule and may include one, two, three or more attached chemical moieties.
  • the polymer may be of any molecular weight, and may be branched or unbranched.
  • the preferred molecular weight is between about 1 kDa and about 100 kDa (the term "about” indicating that in preparations of polyethylene glycol, some molecules will weigh more, some less, than the stated molecular weight) for ease in handling and manufacturing.
  • polymers should be attached to the polypeptide with consideration of effects on functional or antigenic domains of the polypeptide. There are a number of attachment methods available to those skilled in the art (e.g., EP 0 401 384 (coupling PEG to G-CSF) and Malik et al. (1992) Exp Hematol. September;20(8): 1028-35 (pegylation of GM-CSF using tresyl chloride)).
  • polyethylene glycol may be covalently bound through amino acid residues via a reactive group, such as a free amino or carboxyl group.
  • Reactive groups are those to which an activated polyethylene glycol molecule may be bound.
  • the amino acid residues having a free amino group may include lysine residues and the N-terminal amino acid residues; those having a free carboxyl group may include aspartic acid residues, glutamic acid residues and the C-terminal amino acid residue.
  • Sulfhydryl groups may also be used as a reactive group for attaching the polyethylene glycol molecules.
  • the attachment sometimes is at an amino group, such as attachment at the N-terminus or lysine group.
  • Proteins can be chemically modified at the N-terminus.
  • polyethylene glycol as an illustration of such a composition, one may select from a variety of polyethylene glycol molecules (by molecular weight, branching, and the like), the proportion of polyethylene glycol molecules to protein (polypeptide) molecules in the reaction mix, the type of pegylation reaction to be performed, and the method of obtaining the selected N-terminally pegylated protein.
  • the method of obtaining the N- terminally pegylated preparation i.e., separating this moiety from other monopegylated moieties if necessary
  • Selective proteins chemically modified at the N-terminus may be accomplished by reductive alkylation, which exploits differential reactivity of different types of primary amino groups (lysine versus the N-terminal) available for derivatization in a particular protein. Under the appropriate reaction conditions, substantially selective derivatization of the protein at the N-terminus with a carbonyl group containing polymer is achieved.
  • Nucleotide sequences and polypeptide sequences that are substantially identical to a PADI2, APOB, IL1R 2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B and the target polypeptide sequences encoded by those nucleotide sequences, respectively, are included herein.
  • the term "substantially identical" as used herein refers to two or more nucleic acids or polypeptides sharing one or more identical nucleotide sequences or polypeptide sequences, respectively.
  • nucleotide sequences or polypeptide sequences that are 55% or more, 60%> or more, 65% or more, 70% or more, 75%> or more, 80% or more, 85% or more, 90% or more, 95% or more (each often within a 1%, 2%, 3%> or 4% variability) identical to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, or other nucleotide sequence referenced in Table B, or the encoded target polypeptide amino acid sequences.
  • One test for determining whether two nucleic acids are substantially identical is to determine the percent of identical nucleotide sequences or polypeptide sequences shared between the nucleic acids or polypeptides.
  • Calculations of sequence identity are often performed as follows. Sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison pu ⁇ oses).
  • the length of a reference sequence aligned for comparison purposes is sometimes 30% or more, 40% or more, 50%> or more, often 60%) or more, and more often 70% or more, 80% or more, 90% or more, or 100% of the length of the reference sequence.
  • nucleotides or amino acids at corresponding nucleotide or polypeptide positions, respectively are then compared among the two sequences. When a position in the first sequence is occupied by the same nucleotide or amino acid as the corresponding position in the second sequence, the nucleotides or amino acids are deemed to be identical at that position.
  • the percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, introduced for optimal alignment of the two sequences. [0088] Comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm.
  • Percent identity between two amino acid or nucleotide sequences can be determined using the algorithm of Meyers & Miller, CABIOS 4: 11-17 (1989), which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4. Also, percent identity between two amino acid sequences can be determined using the Needleman & Wunsch, J. Mol. Biol. 48: 444-453 (1970) algorithm which has been incorporated into the GAP program in the GCG software package (available at the http address www.gcg.com), using either a Blossum 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6.
  • Percent identity between two nucleotide sequences can be determined using the GAP program in the GCG software package (available at http address www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6.
  • a set of parameters often used is a Blossum 62 scoring matrix with a gap open penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.
  • Another manner for determining if two nucleic acids are substantially identical is to assess whether a polynucleotide homologous to one nucleic acid will hybridize to the other nucleic acid under stringent conditions.
  • stringent conditions refers to conditions for hybridization and washing. Stringent conditions are known to those skilled in the art and can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. , 6.3.1-6.3.6 (1989). Aqueous and non-aqueous methods are described in that reference and either can be used.
  • An example of stringent hybridization conditions is hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 50°C.
  • stringent hybridization conditions are hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 55°C.
  • a further example of stringent hybridization conditions is hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 60°C.
  • stringent hybridization conditions are hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 65°C.
  • stringency conditions are 0.5M sodium phosphate, 7% SDS at 65°C, followed by one or more washes at 0.2X SSC, 1% SDS at 65°C.
  • An example of a substantially identical nucleotide sequence to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B is one that has a different nucleotide sequence but still encodes the same polypeptide sequence encoded by the nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B.
  • nucleotide sequence that encodes a polypeptide having a polypeptide sequence that is more than 70% or more identical to, sometimes more than 75% or more, 80%) or more, or 85% or more identical to, and often more than 90% or more and 95%o or more identical to a polypeptide sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B.
  • Nucleotide sequences in SEQ ID NO: 1-13 or referenced in Table B and amino acid sequences of encoded polypeptides can be used as "query sequences" to perform a search against public databases to identify other family members or related sequences, for example.
  • Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul et al, J. Mol. Biol. 215: 403-10 (1990).
  • Gapped BLAST can be utilized as described in Altschul et al, Nucleic Acids Res. 25(17): 3389-3402 (1997).
  • default parameters of the respective programs e.g., XBLAST and NBLAST
  • XBLAST and NBLAST can be used (see the http address www.ncbi.nlm.nih.gov).
  • SNPs in a sequence substantially identical to a sequence in SEQ ID NO: 1-13 or referenced in Table B can be identified at nucleotide positions that match (i.e., align) with nucleotides at SNP positions in each nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B.
  • insertion or deletion of a nucleotide sequence from a reference sequence can change the relative positions of other polymorphic sites in the nucleotide sequence.
  • Substantially identical nucleotide and polypeptide sequences include those that are naturally occurring, such as allelic variants (same locus), splice variants, homologs (different locus), and orthologs (different organism) or can be non-naturally occurring.
  • Non-naturally occurring variants can be generated by mutagenesis techniques, including those applied to polynucleotides, cells, or organisms.
  • the variants can contain nucleotide substitutions, deletions, inversions and insertions. Variation can occur in either or both the coding and non-coding regions. The variations can produce both conservative and non-conservative amino acid substitutions (as compared in the encoded product).
  • Orthologs, homologs, allelic variants, and splice variants can be identified using methods known in the art. These variants normally comprise a nucleotide sequence encoding a polypeptide that is 50% or more, about 55% or more, often about 70-75% or more or about 80-85%) or more, and sometimes about 90-95% or more identical to the amino acid sequences of target polypeptides or a fragment thereof. Such nucleic acid molecules can readily be identified as being able to hybridize under stringent conditions to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B or a fragment of this sequence.
  • nucleic acid molecules corresponding to orthologs, homologs, and allelic variants of a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B can further be identified by mapping the sequence to the same chromosome or locus as the nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B.
  • substantially identical nucleotide sequences may include codons that are altered with respect to the naturally occurring sequence for enhancing expression of a target polypeptide in a particular expression system.
  • the nucleic acid can be one in which one or more codons are altered, and often 10% or more or 20% or more of the codons are altered for optimized expression in bacteria (e.g., E. coli.), yeast (e.g., S. cervesiae), human (e.g., 293 cells), insect, or rodent (e.g., hamster) cells.
  • Methods for prognosing and diagnosing osteoarthritis are included herein. These methods include detecting the presence or absence of one or more polymorphic variations in a nucleotide sequence associated with osteoarthritis, such as variants in or around the loci set forth herein, or a substantially identical sequence thereof, in a sample from a subject, where the presence of a polymorphic variant described herein is indicative of a risk of osteoarthritis. Determining a risk of osteoarthritis sometimes refers to determining whether an individual is at an increased risk of osteoarthritis (e.g., intermediate risk or higher risk).
  • nucleotide sequence comprises a polynucleotide sequence selected from the group consisting of: (a) a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1- 13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more
  • polymorphic variants at the positions described herein are detected for determining a risk of osteoarthritis, and polymorphic variants at positions in linkage disequilibrium with these positions are detected for determining a risk of osteoarthritis.
  • the terms "SEQ ID NO: 1-13" and other nucleotide sequences "referenced in Table B” refers to individual sequences in SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 or any individual sequence referenced in Table B, or any individual nucleic acid sequence provided in the sequence listing, including SEQ ID NO: 14-36 each sequence being separately applicable to embodiments described herein.
  • Risk of osteoarthritis sometimes is expressed as a probability, such as an odds ratio, percentage, or risk factor. Risk often is based upon the presence or absence of one or more polymorphic variants described herein, and also may be based in part upon phenotypic traits of the individual being tested. Methods for calculating risk based upon patient data are well known (see, e.g., Agresti, Categorical Data Analysis, 2nd Ed. 2002. Wiley). Allelotyping and genotyping analyses may be carried out in populations other than those exemplified herein to enhance the predictive power of the prognostic method. These further analyses are executed in view of the exemplified procedures described herein, and may be based upon the same polymorphic variations or additional polymorphic variations.
  • determining the presence of a combination of two or more polymorphic variants associated with osteoarthritis in one or more genetic loci (e.g., one or more genes) of the sample is determined to identify, quantify and/or estimate, risk of osteoarthritis.
  • the risk often is the probability of having or developing osteoarthritis.
  • the risk sometimes is expressed as a relative risk with respect to a population average risk of osteoarthritis, and sometimes is expressed as a relative risk with respect to the lowest risk group.
  • Such relative risk assessments often are based upon penetrance values determined by statistical methods, and are particularly useful to clinicians and insurance companies for assessing risk of osteoarthritis (e.g., a clinician can target appropriate detection, prevention and therapeutic regimens to a patient after determining the patient's risk of osteoarthritis, and an insurance company can fine tune actuarial tables based upon population genotype assessments of osteoarthritis risk).
  • Risk of osteoarthritis sometimes is expressed as an odds ratio, which is the odds of a particular person having a genotype has or will develop osteoarthritis with respect to another genotype group (e.g., the most disease protective genotype or population average).
  • the determination is utilized to identify a subject at risk of osteoarthritis.
  • two or more polymorphic variations are detected in two or more regions in human genomic DNA associated with increased risk of osteoarthritis, such as a locus containing a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 or other locus referenced in Table B, for example.
  • a locus containing a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 or other locus referenced in Table B for example.
  • 3 or more, or 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 80, 90, 100 or more polymorphic variants are detected in the sample.
  • polymorphic variants are detected in a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 region or other region referenced in Table B, for example.
  • polymorphic variants are detected at two or three positions in a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B.
  • polymorphic variants are detected at other genetic loci (e.g., the polymorphic variants can be detected in a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B in addition to other loci or only in other loci), where the other loci include but are not limited to those described in patent applications 60/559,011; 60/559,202; 60/559,203; 60/559,042; 60/559,275; 60/559,040 and 60/559,225, each of which is entitled “Methods for Identifying Risk of Osteoarthritis and Treatments Thereof," each of which was filed on 1 April 2004 and each of which is incorporated herein by reference in its entirety in jurisdictions allowing incorporation by reference.
  • Results from prognostic tests may be combined with other test results to diagnose osteoarthritis.
  • prognostic results may be gathered, a patient sample may be ordered based on a determined predisposition to osteoarthritis, the patient sample is analyzed, and the results of the analysis may be utilized to diagnose osteoarthritis.
  • osteoarthritis diagnostic method can be developed from studies used to generate prognostic methods in which populations are stratified into subpopulations having different progressions of osteoarthritis.
  • prognostic results may be gathered, a patient's risk factors for developing osteoarthritis (e.g., age, weight, occupational history, race, diet) analyzed, and a patient sample may be ordered based on a determined predisposition to osteoarthritis.
  • the nucleic acid sample typically is isolated from a biological sample obtained from a subject.
  • nucleic acid can be isolated from blood, saliva, sputum, urine, cell scrapings, and biopsy tissue.
  • the nucleic acid sample can be isolated from a biological sample using standard techniques, such as the technique described in Example 2.
  • the term "subject” refers primarily to humans but also refers to other mammals such as dogs, cats, and ungulates (e.g., cattle, sheep, and swine). Subjects also include avians (e.g., chickens and turkeys), reptiles, and fish (e.g., salmon), as embodiments described herein can be adapted to nucleic acid samples isolated from any of these organisms.
  • the nucleic acid sample may be isolated from the subject and then directly utilized in a method for determining the presence of a polymorphic variant, or alternatively, the sample may be isolated and then stored (e.g., frozen) for a period of time before being subjected to analysis.
  • the presence or absence of a polymorphic variant is determined using one or both chromosomal complements represented in the nucleic acid sample. Determining the presence or absence of a polymorphic variant in both chromosomal complements represented in a nucleic acid sample from a subject having a copy of each chromosome is useful for determining the zygosity of an individual for the polymorphic variant (i.e., whether the individual is homozygous or heterozygous for the polymorphic variant). Any oligonucleotide-based diagnostic may be utilized to determine whether a sample includes the presence or absence of a polymo ⁇ hic variant in a sample.
  • primer extension methods For example, primer extension methods, ligase sequence determination methods (e.g., U.S. Pat. Nos. 5,679,524 and 5,952,1 '4, and WO 01/27326), mismatch sequence determination methods (e.g., U.S. Pat. Nos. 5,851,770; 5,958,692; 6,110,684; and 6,183,958), microarray sequence determination methods, restriction fragment length polymorphism (RFLP), single strand conformation polymorphism detection (SSCP) (e.g., U.S. Pat. Nos.
  • RFLP restriction fragment length polymorphism
  • SSCP single strand conformation polymorphism detection
  • Oligonucleotide extension methods typically involve providing a pair of oligonucleotide primers in a polymerase chain reaction (PCR) or in other nucleic acid amplification methods for the purpose of amplifying a region from the nucleic acid sample that comprises the polymorphic variation.
  • PCR polymerase chain reaction
  • One oligonucleotide primer is complementary to a region 3' of the polymorphism and the other is complementary to a region 5' of the polymorphism.
  • a PCR primer pair may be used in methods disclosed in U.S. Pat. Nos.
  • PCR primer pairs may also be used in any commercially available machines that perform PCR, such as any of the GENEAMP ® Systems available from Applied Biosystems.
  • oligonucleotide primers based upon a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B using knowledge available in the art.
  • PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B using knowledge available in the art.
  • an extension oligonucleotide that hybridizes to the amplified fragment adjacent to the polymorphic variation.
  • the term "adjacent" refers to the 3' end of the extension oligonucleotide being often 1 nucleotide from the 5' end of the polymorphic site, and sometimes 2, 3, 4, 5, 6, 7, 8, 9, or 10 nucleotides from the 5' end of the polymorphic site, in the nucleic acid when the extension oligonucleotide is hybridized to the nucleic acid.
  • the extension oligonucleotide then is extended by one or more nucleotides, and the number and/or type of nucleotides that are added to the extension oligonucleotide determine whether the polymorphic variant is present. Oligonucleotide extension methods are disclosed, for example, in U.S. Pat. Nos.
  • a microarray can be utilized for determining whether a polymorphic variant is present or absent in a nucleic acid sample.
  • a microarray may include any oligonucleotides described herein, and methods for making and using oligonucleotide microarrays suitable for diagnostic use are disclosed in U.S. Pat. Nos.
  • the microarray typically comprises a solid support and the oligonucleotides may be linked to this solid support by covalent bonds or by non-covalent interactions.
  • the oligonucleotides may also be linked to the solid support directly or by a spacer molecule.
  • a microarray may comprise one or more oligonucleotides complementary to a polymorphic site set forth herein.
  • a kit also may be utilized for determining whether a polymorphic variant is present or absent in a nucleic acid sample.
  • a kit often comprises one or more pairs of oligonucleotide primers useful for amplifying a fragment of a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B or a substantially identical sequence thereof, where the fragment includes a polymorphic site.
  • the kit sometimes comprises a polymerizing agent, for example, a thermostable nucleic acid polymerase such as one disclosed in U.S. Pat. Nos. 4,889,818 or 6,077,664.
  • the kit often comprises an elongation oligonucleotide that hybridizes to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B in a nucleic acid sample adjacent to the polymorphic site.
  • the kit includes an elongation oligonucleotide, it also often comprises chain elongating nucleotides, such as dATP, dTTP, dGTP, dCTP, and dITP, including analogs of dATP, dTTP, dGTP, dCTP and dITP, provided that such analogs are substrates for a thermostable nucleic acid polymerase and can be incorporated into a nucleic acid chain elongated from the extension oligonucleotide.
  • chain elongating nucleotides would be one or more chain terminating nucleotides such as ddATP, ddTTP, ddGTP, ddCTP, and the like.
  • the kit comprises one or more oligonucleotide primer pairs, a polymerizing agent, chain elongating nucleotides, at least one elongation oligonucleotide, and one or more chain terminating nucleotides.
  • Kits optionally include buffers, vials, microtiter plates, and instructions for use.
  • a subject homozygous for an allele associated with an increased risk of osteoarthritis is at a comparatively high risk of osteoarthritis
  • a subject heterozygous for an allele associated with an increased risk of osteoarthritis is at a comparatively intermediate risk of osteoarthritis
  • a subject homozygous for an allele associated with a decreased risk of osteoarthritis is at a comparatively low risk of osteoarthritis.
  • a genotype may be assessed for a complementary strand, such that the complementary nucleotide at a particular position is detected.
  • an epitope associated with increased risk of osteoarthritis in the polypeptide e.g. , an epitope comprising a valine at position 245 in an IR1LR1 polypeptide.
  • Pharmacogenomics is a discipline that involves tailoring a treatment for a subject according to the subject's genotype as a particular treatment regimen may exert a differential effect depending upon the subject's genotype. For example, based upon the outcome of a prognostic test described herein, a clinician or physician may target pertinent information and preventative or therapeutic treatments to a subject who would be benefited by the information or treatment and avoid directing such information and treatments to a subject who would not be benefited (e.g., the treatment has no therapeutic effect and/or the subject experiences adverse side effects).
  • the following is an example of a pharmacogenomic embodiment.
  • a particular treatment regimen can exert a differential effect depending upon the subject's genotype.
  • a candidate therapeutic exTiibits a significant interaction with a major allele and a comparatively weak interaction with a minor allele (e.g., an order of magnitude or greater difference in the interaction)
  • such a therapeutic typically would not be administered to a subject genotyped as being homozygous for the minor allele, and sometimes not administered to a subject genotyped as being heterozygous for the minor allele.
  • a candidate therapeutic is not significantly toxic when administered to subjects who are homozygous for a major allele but is comparatively toxic when administered to subjects heterozygous or homozygous for a minor allele
  • the candidate therapeutic is not typically administered to subjects who are genotyped as being heterozygous or homozygous with respect to the minor allele.
  • the methods described herein are applicable to pharmacogenomic methods for preventing, alleviating or treating osteoarthritis.
  • a nucleic acid sample from an individual may be subjected to a prognostic test described herein.
  • a treatment or preventative regimen is specifically prescribed and/or administered to individuals who will most benefit from it based upon their risk of developing osteoarthritis assessed by the methods described herein.
  • certain embodiments are directed to a method for reducing osteoarthritis in a subject, which comprises: detecting the presence or absence of a polymorphic variant associated with osteoarthritis in a nucleotide sequence in a nucleic acid sample from a subject, where the nucleotide sequence comprises a polynucleotide sequence selected from the group consisting of: (a) a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, or a nucleotide sequence about 90% or more identical to a nucleotide sequence of SEQ ID
  • predisposition results may be utilized in combination with other test results to diagnose osteoarthritis .
  • Certain preventative treatments often are prescribed to subjects having a predisposition to ost oarthritis and where the subject is diagnosed with osteoarthritis or is diagnosed as having symptoms indicative of an early stage of osteoarthritis.
  • the treatment sometimes is preventative (e.g., is prescribed or administered to reduce the probability that osteoarthritis arises or progresses), sometimes is therapeutic, and sometimes delays, alleviates or halts the progression of osteoarthritis.
  • Any known preventative or therapeutic treatment for alleviating or preventing the occurrence of osteoarthritis is prescribed and/or administered. For example, the treatment often is directed to decreasing pain and improving joint movement.
  • OA treatments include exercises to keep joints flexible and improve muscle strength.
  • Different medications to control pain including corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs, e.g., Voltaren); cyclooxygenase-2 (COX-2) inhibitors (e.g-. , Celebrex, Vioxx, Mobic, and Bextra); monoclonal antibodies (e.g., Remicade); tumor necrosis factor inhibitors (e.g., Enbrel); or injections of glucocorticoids, hyaluronic acid or chondrotin sulfate into joints that are inflamed and not responsive to NSAIDS.
  • NSAIDs nonsteroidal anti-inflammatory drugs
  • COX-2 cyclooxygenase-2
  • COX-2 cyclooxygenase-2
  • monoclonal antibodies e.g., Remicade
  • tumor necrosis factor inhibitors e.g., Enbrel
  • chondroitin sulfate also may be used as a therapeutic, as it may increase hyaluronic acid levels and viscosity of synovial fluid, and decrease collagenase levels in synovial fluid.
  • glucosamine can serve as an OA therapeutic as delivering it into joints may inhibit enzymes involved in cartilage degradation and enhance the production of hyaluronic acid.
  • acetaminophen may be used.
  • Other treatments include: heat/cold therapy for temporary pain relief; joint protection to prevent strain or stress on painful joints; surgery to relieve chronic pain in damaged joints; and weight control to prevent extra stress on weight-bearing joints.
  • osteoarthritis preventative and treatment information can be specifically targeted to subjects in need thereof (e.g., those at risk of developing osteoarthritis or those in an early stage of osteoarthritis), provided herein is a method for preventing or reducing the risk of developing osteoarthritis in a subject, which comprises: (a) detecting the presence or absence of a polymorphic variation associated with osteoarthritis at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) identifying a subject with a predisposition to osteoarthritis, whereby the presence of the polymorphic variation is indicative of a predisposition to osteoarthritis in the subject; and (c) if such a predisposition is identified, providing the subject with information about methods or products to prevent or reduce osteoarthritis or to delay the onset of osteoarthritis.
  • Also provided is a method of targeting information or advertising to a subpopulation of a human population based on the subpopulation being genetically predisposed to a disease or condition which comprises: (a) detecting the presence or absence of a polymorphic variation associated with osteoarthritis at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) identifying the subpopulation of subjects in which the polymorphic variation is associated with osteoarthritis; and (c) providing information only to the subpopulation of subjects about a particular product which may be obtained and consumed or applied by the subject to help prevent or delay onset of the disease or condition.
  • Pharmacogenomics methods also may be used to analyze and predict a response to osteoarthritis treatment or a drug. For example, if pharmacogenomics analysis indicates a likelihood that an individual will respond positively to osteoarthritis treatment with a particular drug, the drug may be administered to the individual. Conversely, if the analysis indicates that an individual is likely to respond negatively to treatment with a particular drug, an alternative course of treatment may be prescribed. A negative response may be defined as either the absence of an efficacious response or the presence of toxic side effects.
  • the response to a therapeutic treatment can be predicted in a background study in which subjects in any of the following populations are genotyped: a population that responds favorably to a treatment regimen, a population that does not respond significantly to a treatment regimen, and a population that responds adversely to a treatment regimen (e.g., exhibits one or more side effects). These populations are provided as examples and other populations and subpopulations may be analyzed. Based upon the results of these analyses, a subject is genotyped to predict whether he or she will respond favorably to a treatment regimen, not respond significantly to a treatment regimen, or respond adversely to a treatment regimen. [0116] The tests described herein also are applicable to clinical drug trials.
  • One or more polymorphic variants indicative of response to an agent for treating osteoarthritis or to side effects to an agent for treating osteoartliritis may be identified using the methods described herein. Thereafter, potential participants in clinical trials of such an agent may be screened to identify those individuals most likely to respond favorably to the drug and exclude those likely to experience side effects. In that way, the effectiveness of drug treatment may be measured in individuals who respond positively to the drug, without lowering the measurement as a result of the inclusion of individuals who are unlikely to respond positively in the study and without risking undesirable safety problems.
  • another embodiment is a method of selecting an individual for inclusion in a clinical trial of a treatment or drug comprising the steps of: (a) obtaining a nucleic acid sample from an individual; (b) determining the identity of a polymorphic variation which is associated with a positive response to the treatment or the drug, or at least one polymorphic variation which is associated with a negative response to the treatment or the drug in the nucleic acid sample, and (c) including the individual in the clinical trial if the nucleic acid sample contains said polymorphic variation associated with a positive response to the treatment or the drug or if the nucleic acid sample lacks said polymorphic variation associated with a negative response to the treatment or the drug.
  • the polymorphic variation may be in a sequence selected individually or in any combination from the group consisting of (i) a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (ii) a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (iii) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, or a nucleotide sequence about 90% or more identical to a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; and (iv) a fragment of
  • step (c) optionally comprises administering the drug or the treatment to the individual if the nucleic acid sample contains the polymorphic variation associated with a positive response to the treatment or the drug and the nucleic acid sample lacks said biallelic marker associated with a negative response to the treatment or the drug.
  • Also provided herein is a method of partnering between a diagnostic/prognostic testing provider and a provider of a consumable product, which comprises: (a) the diagnostic/prognostic testing provider detects the presence or absence of a polymorphic variation associated with osteoarthritis at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) the diagnostic/prognostic testing provider identifies the subpopulation of subjects in which the polymorphic variation is associated with osteoarthritis; (c) the diagnostic/prognostic testing provider forwards information to the subpopulation of subjects about a particular product which may be obtained and consumed or applied by t ie subject to help prevent or delay onset of the disease or condition; and (d) the provider of a consumable product forwards to the diagnostic test provider a fee every time the diagnostic/prognostic test provider forwards information to the subject as set forth in step (c) above.
  • compositions comprising a cell from a subject having osteoarthritis or at risk of osteoarthritis and one or more molecules specifically directed and targeted to a nucleic acid comprising a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, other nucleotide sequence referenced in Table B, or an encoded amino acid sequence referenced herein.
  • a nucleic acid comprising a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, other nucleotide sequence referenced in Table B, or an encoded amino acid sequence referenced herein.
  • Such directed molecules include, but are not limited to, a compound that binds to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, or other nucleotide sequence referenced in Table B, or encoded amino acid sequence; a RNAi or siRNA molecule having a strand complementary or substantially complementary to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B (e.g., hybridizes to a PADI2, APOB, IL1JRL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nu
  • the antibody selectively binds to an epitope comprising an amino acid encoded by rsl367117, rsl041973 and rs398829.
  • the osteoarthritis directed molecule interacts with, a nucleic acid or polypeptide variant associated with osteoarthritis, such as variants referenced herein.
  • the osteoarthritis directed molecule interacts with a polypeptide involved ir a signal pathway of a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAA4TS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a nucleic acid comprising such a nucleotide sequence.
  • Compositions sometimes include an adjuvant known to stimulate an immune response, and in certain embodiments, an adjuvant that stimulates a T-cell lymphocyte response.
  • Adjuvants are known, including but not limited to an aluminum adjuvant (e.g., aluminum hydroxide); a cytokine adjuvant or adjuvant that stimulates a cytokine response (e.g., interleukin (IL)-12 and/or gamma- interferon cytokines); a Freund-type mineral oil adjuvant emulsion (e.g., Freund's complete or incomplete adjuvant); a synthetic lipoid compound; a copolymer adjuvant (e.g., TitreMax); a saponin; Quil A; a liposome; an oil-in- water emulsion (e.g: , an emulsion stabilized by Tween 80 and pluronic polyoxyethlene/polyoxypropylene block copolymer (Syntex Adjuvant Formulation); TitreMax; detoxified endotoxin (MPL) and mycobacterial cell wall components (TDW, CWS) in 2% squalene (
  • compositions are useful for generating an immune response against osteoarthritis directed molecule (e.g., an " HLA-binding subsequence within a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence).
  • an immune response against osteoarthritis directed molecule e.g., an " HLA-binding subsequence within a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence.
  • a peptide having an amino acid subsequence of a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence is delivered to a subject, where the subsequence binds to an HLA molecule and induces a CTL lymphocyte response.
  • the peptide sometimes is delivered to the subject as an isolated peptide or as a minigene in a plasmid that encodes the peptide.
  • the cell may be in a group of cells cultured in vitro or in a tissue maintained in vitro or present in an animal in vivo (e.g., a rat, mouse, ape or human).
  • a composition comprises a component from a cell such as a nu leic acid molecule (e.g., genomic DNA), a protein mixture or isolated protein, for example.
  • a nu leic acid molecule e.g., genomic DNA
  • the aforementioned compositions have utility in diagnostic, prognostic and pharmacogenomic methods described previously and in therapeutics described hereafter. Certain osteoarthritis directed molecules are described in greater detail below.
  • Compounds can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; peptoid libraries (libraries of molecules having the functionalities of peptides, but with a novel, non-peptide backbone which are resistant to enzymatic degradation but which nevertheless remain bioactive (see, e.g., Zuckermann et al., J. Med. Chem.37: 2678-85 (1994)); spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; "one-bead one-compound” library methods; and synthetic library methods using affinity chromatography selection..
  • Biolibrary and peptoid library approaches are typically limited to peptide libraries, while the other approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam, Anticancer Drug Des. 12: 145, (1997)).
  • Examples of methods for synthesizing molecular libraries are described, for example, in DeWitt et al., Proc. Natl. Acad. Sci. U.S.A. 90: 6909 (1993); Erb et al., Proc. Natl. Acad. Sci. USA 91: 11422 (1994); Zuckermann et al., J. Med. Chem.
  • a compound sometimes alters expression and sometimes alters activity of a polypeptide target and may be a small molecule.
  • Small molecules include, but are not limited to, peptides, peptidomimetics (e.g., peptoids), amino acids, amino acid analogs, polynucleotides, polynucleotide analogs, nucleotides, nucleotide analogs, organic or inorganic compounds (i.e., including heteroorganic and organometallic compounds) having a molecular weight less than about 10,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 5,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 1,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 500 grams per mole, and salts, esters, and other pharmaceutically acceptable forms of such compounds.
  • peptides e.g., peptoids
  • amino acids amino acid analogs
  • polynucleotides polynucleotide analogs
  • nucleotides nucleotide analogs
  • an "antisense” nucleic acid refers to a nucleotide sequence complementary to a "sense" nucleic acid encoding a polypeptide, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence.
  • the antisense nucleic acid can be complementary to an entire coding strand, or to a portion thereof or a substantially identical sequence thereof.
  • the antisense nucleic acid molecule is antisense to a "noncoding region" of the coding strand of a nucleotide sequence (e.g., 5' and 3' untranslated regions in SEQ ID NO: 1-13 or a nucleotide sequence referenced in Table E5).
  • a nucleotide sequence e.g., 5' and 3' untranslated regions in SEQ ID NO: 1-13 or a nucleotide sequence referenced in Table E5
  • An antisense nucleic acid can be designed such that it is complementary to the entire coding region of an mRNA encoded by a nucleotide sequence (e.g., SEQ ID NO: 1-13, SEQ ID NO: 14-36 or a nucleotide sequence referenced in Table B), and often the antisense nucleic acid is an oligonucleotide antisense to only a portion of a coding or noncoding region of the mRNA.
  • the antisense oligonucleotide can be complementary to the region surrounding the translation start site of the mRNA, e.g., between the -10 and +10 regions of the target gene nucleotide sequence of interest.
  • An antisense oligonucleotide can be, for example, about 7, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, or more nucleotides in length.
  • the antisense nucleic acids which include the ribozymes described hereafter, can be designed to target a PADI2, APOB, IL1JRL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, often a variant associated with osteoarthritis, or a substantially identical sequence thereof.
  • An antisense nucleic acid can be constructed using chemical synthesis and enzymatic ligation reactions using standard procedures.
  • an antisense nucleic acid e.g., an antisense oligonucleotide
  • an antisense nucleic acid can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used.
  • Antisense nucleic acid also can be produced biologically using an expression vector into whic-h a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).
  • antisense nucleic acids When utilized as therapeutics, antisense nucleic acids typically are administered to a subject (e.g., by direct injection at a tissue site) or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a polypeptide and thereby inhibit expression of the polypeptide, for example, by inhibiting transcription and/or translation.
  • antisense nucleic acid molecules can be modified to target selected cells and then are administered systemically.
  • antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, for example, by linking antisense nucleic acid molecules to peptides or antibodies which bind to cell surface receptors or antigens.
  • Antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. Sufficient intracellular concentrations of antisense molecules are achieved by incorporating a strong promoter, such as a pol II or pol III promoter, in the vector construct.
  • Antisense nucleic acid molecules sometimes are alpha-anomeric nucleic acid molecules.
  • nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual beta-units, the strands run parallel to each other (Gaultier et al., Nucleic Acids. Res. 15: 6625-6641 (1987)).
  • Antisense nucleic acid molecules can also comprise a 2'-o- methylribonucleotide (Inoue et al., Nucleic Acids Res. 15: 6131-6148 ( 1987)) or a chimeric RNA-DNA analogue (Inoue et al., FEBS Lett. 215: 327-330 (1987)).
  • an antisense nucleic acid is a ribozyme.
  • a ribozyme having specificity for a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B can include one or more sequences complementary to such a nucleotide sequence, and a sequence having a known catalytic region responsible for mRNA cleavage (see e.g., U.S. Pat. No.
  • a derivative of a Xetrahymena L-19 IVS RNA is sometimes utilized in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a mRNA (see e.g., Cech et al. U.S . Patent No. 4,987,071; and Cech et al. U.S. Patent No. 5, 116,742).
  • target mRNA sequences can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules (see e.g., Bartel & Szostak, Science 261 : 1411-1418 (1993)).
  • Osteoarthritis directed molecules include in certain embodiments nucleic acids that can form triple helix structures with a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a substantially identical sequence thereof, especially one that includes a regulatory region that controls expression of a polypeptide.
  • Gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of a nucleotide sequence referenced herein or a substantially identical sequence (e.g., promoter and/or enhancers) to form triple helical structures that prevent transcription of a gene in target cells (see e.g., Helene, Anticancer Drug Des. 6(6): 569-84 (1991); Helene et al., Ann. N.Y. Acad. Sci. 660: 27-36 (1992); and Maher, Bioassays 14(12): 807-15 (1992).
  • Potential sequences that can be targeted for triple helix formation can be increased by creating a so-called "switchback" nucleic acid molecule.
  • Switchback molecules are synthesized in an alternating 5'-3 ', 3 '-5' manner, such that they base pair with first one strand of a duplex and then the other, eliminating the necessity for a sizeable stretch of either purines or pyrimidines to be present on one strand of a duplex.
  • Osteoarthritis directed molecules include RNAi and siRNA nncleic acids. Gene expression may be inhibited by the introduction of double-stranded RNA (dsRNA), which induces potent and specific gene silencing, a phenomenon called RNA interference or RNAi. See, e.g., Fire et al., US Patent Number 6,506,559; Tuschl et al. PCT International Publication No .
  • RNA interference RNA interference
  • siRNA refers to a nucleic acid that forms a double stranded RNA and has the ability to reduce or inhibit expression of a gene or target gene when the siRNA is delivered to or expressed in the same cell as the gene or target gene.
  • siRNA refers to short double-stranded RNA formed by the complementary strands. Complementary portions of the silRNA that hybridize to form the double stranded molecule often have substantial or complete identity to the target molecule sequence.
  • an siRNA refers to a nucleic acid that has substantial or complete identity to a target gene and forms a double stranded siRNA.
  • the targeted region often is selected from a given DNA sequence beginning 50 to 100 nucleotides downstream of the start codon. See, e.g., Elbashir et al,. Methods 26:199-213 (2002). Initially, 5' or 3' UTRs and regions nearby the start codon were avoided assuming that UTR-binding proteins and/or translation initiation complexes may interfere with binding of the siRNP or RISC endonuclease complex. Sometimes regions of the target 23 nucleotides in length conforming to the sequence motif AA(N19)TT (N, an nucleotide), and regions with approximately 30%> to 70% G/C-content (often about 50% G/C-content) often are selected..
  • the sequence of the sense siRNA sometimes corresponds to (N19) TT or N21 (position 3 to 23 of the 23-nrt motif), respectively. In the latter case, the 3' end of the sense siRNA often is converted to TT. T ⁇ ie rationale for this sequence conversion is to generate a symmetric duplex with respect to the sequence composition of the sense and antisense 3' overhangs.
  • the antisense siRNA is synthesized as the complement to position 1 to 21 of the 23-nt motif. Because position 1 of the 23-nt motif is not recognized sequence- specifically by the antisense siRNA, the 3'-most nucleotide residue of the antisense siRNA can be chosen deliberately.
  • the penultimate nucleotide of the antisense siRNA (complementary to position 2 of the 23-nt motif) often is complementary to the targeted sequence.
  • TT often is utilized.
  • Respective 21 nucleotide sense and antisense siRNAs often begin with a purine nucleotide and can also be expressed from pol III expression vectors without a change in targeting site. Expression of RNAs from pol III promoters often is efficient when the first transcribed nucleotide is a purine.
  • the sequence of the siRNA can correspond to the full length target gene, or a subsequence thereof.
  • the siRNA is about 15 to about 50 nucleotides in length (e.g., each complementary sequence of the double stranded siRNA is 15-50 nucleotides in length, and the double stra-nded siRNA is about 15-50 base pairs in length, sometimes about 20-30 nucleotides in length or about 20-25 nucleotides in length, e.g., 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides in lengtli.
  • the siRNA sometimes is about 21 nucleotides in length.
  • siRNA nucleic acids can be altered to form modified nucleic acid molecules.
  • the nucleic acids can be altered at base moieties, sugar moieties or phosphate backbone moieties to improve stability, hybridization, or solubility of the molecule.
  • the deoxyribose phosphate backbone of nucleic acid molecules can be modified to generate peptide nucleic acids (see Hyrup et al, Bioorganic & Medicinal Chemistry 4 (1): 5-23 (1996)).
  • peptide nucleic acid refers to a nucleic acid mimic such as a DNA mim-ic, in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only trie four natural nucleobases are retained.
  • the neutral backbone of a PNA can allow for specific hybridization to DNA and RNA under conditions of low ionic strength. Synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described, for example, in Hyrup et al. , (1996) supra and Perry-O'Keefe et al., Proc. Natl. Acad. Sci. 93: 14670-675 (1996).
  • PNA nucleic acids can be used in prognostic, diagnostic, and therapeutic applications.
  • PNAs can be used as antisense or antigene agents for sequence-specific modulation of " gene expression by, for example, inducing transcription or translation arrest or inhibiting replication.
  • PNA nucleic acid molecules can also be used in the analysis of single base pair mutations in a gene, (e.g., by PNA-directed PCR clamping); as "artificial restriction enzymes” when used in combination with other enzymes, (e.g., SI nucleases (Hyrup (1996) supra)); or as probes or primers for DNA sequencing or hybridization (Hyrup et al., (1996) supra; Perry-O'Keefe supra).
  • oligonucleotides may include other appended groups such as peptides (e.g. , for targeting host cell receptors in vivo), or agents facilitating transport across cell membranes (see e.g., Letsinger et al., Proc. Natl. Acad. Sci. USA 86: 6553-6556 (1989); Lema tre et al., Proc. Natl. Acad. Sci. USA 84: 648-652 (1987); PCT Publication No. W088/09810) or the blood-brain barrier (see, e.g., PCT Publication No. W089/10134).
  • peptides e.g., for targeting host cell receptors in vivo
  • agents facilitating transport across cell membranes see e.g., Letsinger et al., Proc. Natl. Acad. Sci. USA 86: 6553-6556 (1989); Lema tre et al., Proc. Natl. Aca
  • oligonucleotides can be modified with hybridization-triggered cleavage agents (See, e.g., Krol et al., Bio-Techniques 6: 958-976 C 1988)) or intercalating agents. (See, e.g., Zon, Pharm. Res. 5: 539-549 (1988) ).
  • the oligonucleotide may be conjugated to another molecule, (e.g., a peptide, hybridization triggered cross- linking agent, transport agent, or hybridization-triggered cleavage agent).
  • molecular beacon oligonucleotide primer and probe mole ules having one or more regions complementary to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, AD MTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a substantially identical sequence thereof, two complementary regions, one having a fluorophore and one a quencher such that the molecular beacon is useful for quantifying the presence of the nucleic acid in a sample.
  • Molecular beacon nucleic acids are described, for example, in Lizardi et al., U.S. Patent No. 5,854,033; Nazarenko et al., U.S. Patent No. 5,866,336, and Livak et al., U.S. Patent 5,876,930.
  • antibody refers to an immunoglobulin molecule or immunologically active portion thereof, i.e., an antigen-binding portion.
  • immunologically active portions of immunoglobulin molecules include F(ab) and F(ab') 2 fragments which can be generated by treating the antibody with an enzyme such as pepsin.
  • An antibody sometimes is a polyclonal, monoclonal, recombinant (e.g., a chimeric or humanized), fully human, non-human (e.g., murine), or a single chain antibody.
  • An antibody may have effector function and can fix complement, and is sometimes coupled to a toxin or imaging agent.
  • a full-length polypeptide or antigenic peptide fragment encoded by a nucleotide sequence referenced herein can be used as an immunogen or can be used to identify antibodies made with other immunogens, e.g., cells, membrane preparations, and the like.
  • An antigenic peptide often includes at least 8 amino acid residues of the amino acid sequences encoded by a nucleotide sequence referenced herein, or substantially identical sequence thereof, and encompasses an epitope.
  • Antigenic peptides sometimes include 10 or more amino acids, 15 or more amino acids, 20 or more amino acids, or 30 or more amino acids. Hydrophilic and hydrophobic fragments of polypeptides sometimes are used as immunogens.
  • Epitopes encompassed by the antigenic peptide are regions located on the surface of the polypeptide (e.g., hydrophilic regions) as well as regions with high antigenicity.
  • an Emini surface probability analysis of the human polypeptide sequence can be used to indicate the regions that have a particularly high probability of being localized to the surface of the polypeptide and are thus likely to constitute surface residues useful for targeting antibody production.
  • the antibody may bind an epitope on any domain or region on polypeptides described herein.
  • chimeric, humanized, and completely human antibodies are useful for applications which include repeated administration to subjects. Chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, can be made using standard recombinant DNA techniques.
  • Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art, for example using methods described in Robinson et al International Application No. PCT/US86/02269; Akira, et al European Patent Application 184,187; Taniguchi, M., European Patent Application 171,496; Morrison et al European Patent Application 173,494; Neuberger et al PCT International Publication No. WO 86/01533; Cabilly et al U.S. Patent No. 4,816,567; Cabilly et al European Patent Application 125,023; Better et al., Science 240: 1041-1043 (1988); Liu et al., Proc. Natl.
  • An antibody can be a single chain antibody.
  • a single chain antibody (scFV) can be engineered (see, e.g., Colcher et al., Ann. N Y Acad. Sci. 880: 263-80 (1999); and Reiter, Clin. Cancer Res. 2: 245-52 (1996)).
  • Single chain antibodies can be dimerized or multimerized to generate multivalent antibodies having specificities for different epitopes of the same target polypeptide.
  • Antibodies also may be selected or modified so that they exhibit reduced or no ability to bind an Fc receptor.
  • an antibody may be an isotype or subtype, fragment or other mutant, which does not support binding to an Fc receptor (e.g., it has a mutagenized or deleted Fc receptor binding region).
  • an antibody (or fragment thereof) may be conjugated to a therapeutic moiety such as a cytotoxin, a therapeutic agent or a radioactive metal ion.
  • a cytotoxin or cytotoxic agent includes any agent that is detrimental to cells.
  • Examples include taxol, cytochalasin B, gramicidin D, ethidium bromide, emetine, mitomycin, etoposide, tenoposide, vincristine, vinblastine, colchicin, doxorubicin, daunorubicin, dihydroxy anthracin dione, mitoxantrone, mithramycin, actinomycin D, 1 dehydrotestosterone, glucocorticoids, procaine, tetracaine, lidocaine, propranolol, and puromycin and analogs or homologs thereof.
  • Therapeutic agents include, but are not limited to, antimetabolites (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), alkylating agents (e.g., mechlorethamine, thiotepa chlorambucil, melphalan, carmustine (BCNU) and lomustine (CCNU), cyclophosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis- dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g.
  • Antibody conjugates can be used for modifying a given biological response.
  • the drug moiety may be a protein or polypeptide possessing a desired biological activity.
  • proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a polypeptide such as tumor necrosis factor, gamma-interferon, alpha-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 ("IL-1"), interleukin-2 (“IL-2”), interleukin-6 (“IL-6”), granulocyte macrophage colony stimulating factor (“GM-CSF”), granulocyte colony stimulating factor (“G-CSF”), or other growth factors.
  • IL-1 interleukin-1
  • IL-2 interleukin-2
  • IL-6 interleukin-6
  • GM-CSF gran
  • an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Patent No. 4,676,980, for example.
  • An antibody e.g., monoclonal antibody
  • An antibody can be used to isolate target polypeptides by standard techniques, such as affinity chromatography or immunoprecipitation.
  • an antibody can be used to detect a target polypeptide (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the polypeptide.
  • Antibodies can be used diagnostically to monitor polypeptide levels in tissue as part of a clinical testing procedure, e.g., to determine the efficacy of a given treatment regimen.
  • Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance (i.e., antibody labeling).
  • detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials.
  • suitable enzymes include horseradish peroxidase, alkaline phosphatase, ⁇ -galactosidase, or acetylcholinesterase;
  • suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin;
  • suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol;
  • examples of bioluminescent materials include luciferase, luciferin, and.
  • an antibody can be utilized as a test molecule for determining whether it can treat osteoarthritis, and as a therapeutic for administration to a subject for treating osteoarthritis.
  • An antibody can be made by immunizing with a purified antigen, or a fragment thereof, e.g., a fragment described herein, a membrane associated antigen, tissues, e.g., crude tissue prepajrations, whole cells, preferably living cells, lysed cells, or cell fractions.
  • a "target molecule” as used herein refers to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleotide sequence referenced in Table B, a substantially identical nucleic acid thereof, or a fragment thereof, and an encoded polypeptide of the foregoing.
  • the methods also comprise determining the presence or absence off an interaction between the test molecule and the target molecule, where the presence of an interaction between the test molecule and the nucleic acid or polypeptide identifies the test molecule as a cai didate osteoarthritis therapeutic.
  • Test molecules and candidate therapeutics include, but are not limited to, compounds. , antisense nucleic acids, siRNA molecules, ribozymes, polypeptides or proteins encoded by a PALDI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B , or a substantially identical sequence or fragment thereof, and immunotherapeutics (e.g., antibodies and HLA-presented polypeptide fragments).
  • immunotherapeutics e.g., antibodies and HLA-presented polypeptide fragments.
  • a test molecule or candidate therapeutic may act as a modulator of target molecule concentration or target molecule function in a system.
  • a “modulator” may agonize (i.e., up-regulates) or antagonize (i.e., down-regulates) a target molecule concentration partially or completely in a system by affecting such cellular functions as DNA replication and/or DNA processing (e.g., DNA methylation or DNA repair), RNA transcription and/or RNA processing (e.g., removal of intronic sequences and/or translocation of spliced mRNA from the nucleus), polypeptide production (e.g., translation of the polypeptide from mRNA), and/or polypeptide post-translational modification (e.g., glycosylation, phosphorylation, and proteolysis of pro-polypeptides).
  • DNA processing e.g., DNA methylation or DNA repair
  • RNA transcription and/or RNA processing e.g., removal of intronic sequences
  • a modulator may also agonize or antagonize a biological function of a target molecule partially or completely, where the function may include adopting a certain structural conformation, interacting with one or more binding partners, ligand binding, catalysis (e.g., phosphorylation, dephosphorylation, hydrolysis, methylation, and isomerization), and an effect upon a cellular event (e.g., effecting progression of osteoarthritis).
  • catalysis e.g., phosphorylation, dephosphorylation, hydrolysis, methylation, and isomerization
  • an effect upon a cellular event e.g., effecting progression of osteoarthritis.
  • any modulator may be utilized, such as a peptidyl arginine deiminase modulator (e.g., PADI2 likely is a peptidyl arginine deiminase) described in WO-09851784 and WO0244360A2 or an apolipoprotein (e.g., APOB includes an apolipoprotein domain) modulatory compound (e.g., WO-2004017969, WO- 03002533, US 6,369,075, WO-02098839, WO-02098871, WO-00177077, WO-00153260, WO- 00105767), antibody (e.g., WO-9600903A1, US 6,309,844 and US 5,330,910) or antisense molecule (e.g., WO03011887A2 and WO03097662A1).
  • a peptidyl arginine deiminase modulator e.g.,
  • system refers to a cell free in vitro environment and a cell-based environment such as a collection of cells, a tissue, an organ, or an organism.
  • a system is "contacted-" with a test molecule in a variety of manners, including adding molecules in solution and allowing them to interact with one another by diffusion, cell injection, and any administration routes in an animal.
  • interaction refers to an effect of a test molecule on test molecule, where the effect sometimes is binding between the test molecule and the target molecule, and sometimes is an observable change in cells, tissue, or organism.
  • titrametric, acidimetric, radiometric, NMR, mono layer, polarographic, spectrophotometric, fluorescent, and ESR assays probative of a target molecule interaction may be utilized.
  • G protein-coupled receptor assays are known, for example, and are described in WO-0242461 and WO-04013285.
  • ADAMTS2 activity and/or ADAMTS2 interactions can be detected and quantified using assays known in the art.
  • an immunoprecipitation assay or a kinase activity assay that employs a kinase-inactivated MEK can be utilized.
  • kinase inactivated MEKs are known in the art, such as a MEK that includes the mutation K97M.
  • mammalian cells e.g., COS or NIH-3T3
  • the cells are co- transfected with oncogenic RAS or SRC or both.
  • Oncogenic RAS or SRC activates ADAMTS2 kinase activity.
  • ADAMTS2 is immunoprecipitated from cell extracts using a monoclonal antibody (e.g., 9E 10) or a polyclonal antibody (e.g., from rabbit) specific for a unique peptide from ADAMTS2.
  • ADAMTS'2 is then resuspended in assay buffer containing GST-Mekl or GST-Mek2 and/or GST-ERK2.
  • [gamma 32 P] ATP can be added to detect and/or quantify phosphorylation activity. Samples are incubated for 5-30 minutes at 30°C, and then the reaction is terminated by addition of EDTA. TJhe samples are centrifuged and the supernatant fractions are collected.
  • Phosphorylation activity is detected using one of two methods: (i) activity of GST-ERK2 kinase can be measured using MBP (myelixi basic protein, a substrate for ERK) as substrate, or (ii) following incubation of immunoprecipitated ADAMTS2 in reaction buffer containing GST-ERK and [gamma 32 P] ATP, transfer of labeled ATP to kinase-dead ERK can be quantified by a phosphor-imager or densitometer following PAGE separation of polypeptide products (phosphorylated and non-phosphorylated forms).
  • MBP myelixi basic protein, a substrate for ERK
  • ADAMTS2 includes a domain having metalloprotease activity, and modulators of such activity are known.
  • modulators are set forth in WO03063762A2; WO-09937625; WO-09918076; WO-09838163; WO-09837877; WO9947550A1; WO0177092AJ; WO0040577A1; W09942436A1; W09838163A1; W09837877A1; WO04014379A1; WO03106381A2; WO03014098A1; WO03014092A1 and WO02096426A1.
  • Test molecule/target molecule interactions can be detected and/or quantified using assays known in the art.
  • an interaction can be determined by labeling the test molecule and/or the target molecule, where the label is covalently or non-covalently attached to the test molecule or target molecule.
  • the label is sometimes a radioactive molecule such as I, I, S or H, which can be detected by direct counting of radioemission or by scintillation counting.
  • enzymatic labels such as horseradish peroxidase, alkaline phosphatase, or luciferase may be utilized where the enzymatic label can be detected by determining conversion of an appropriate substrate to product.
  • presence or absence of an interaction can be determined without labeling.
  • a microphysiometer e.g., Cytosensor
  • LAPS light-addressable potentiometric sensor
  • cells typically include a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleotide sequence referenced in Table B, an encoded polypeptide, or substantially identical nucleic acid or polypeptide thereof, and are often of mammalian origin, although the cell can be of any origin.
  • Whole cells, cell homogenates, and cell fractions e.g., cell membrane fractions
  • Wh-ere interactions between a test molecule with a target polypeptide are monitored, soluble and/or membrane bound forms of the polypeptide may be utilized.
  • solubilizing agents include non-ionic detergents such as n-octylglucoside, n-dodecylglucoside, n-dodecylmaltoside, octanoyl-N- methylglucamide, decanoyl-N-methylglucamide, Triton® X-100, Triton® X-114, Thesit®, Isotridecypoly(ethylene glycol ether) n , 3-[(3-cholamidopropyl)dimethylamminio]-l -propane sulfonate
  • test molecule 3-[(3-cholamidopropyl)dimethylamminio]-2-hydroxy-l-propane sulfonate (CHAPSO), or N- dodecyl-N,N-dimethyl-3-ammonio-l-propane sulfonate.
  • FET fluorescence energy transfer
  • a fluorophore label on a first, "donor” molecule is selected such that its emitted fluorescent energy will be absorbed by a fluorescent label on a second, “acceptor” molecule, which in turn is able to fluoresce due to the absorbed energy.
  • the "donor” polypeptide molecule may simply utilize the natural fluorescent energy of tryptophan residues.
  • Labels are chosen that emit different wavelengths of light, such that the "acceptor” molecule label may be differentiated from that of the "donor". Since the efficiency of energy transfer between the labels is related to the distance separating the molecules, the spatial relationship between the molecules can be assessed. In a situation in which binding occurs between the molecules, the fluorescent emission of the "acceptor" molecule label in the assay should be maximal.
  • An FET binding event can be conveniently measured through standard fluorometric detection means well known in the art (e.g., using a fluorimeter).
  • determining the presence or absence of an interaction between a test molecule and a target molecule can be effected by monitoring surface plasmon resonance (see, e.g., Sjolander & Urbaniczk, Anal. Chem. 63: 2338-2345 (1991) and Szabo et al, Curr. Opin. Struct. Biol 5: 699-705 (1995)).
  • “Surface plasmon resonance” or “biomolecular interaction analysis (BIA)” can be utilized to detect biospecific interactions in real time, without labeling any of the interactants (e.g., BIAcore). Changes in the mass at the binding surface (indicative of a binding event) result in alterations of the refractive index of light near the surface (the optical phenomenon of surface plasmon resonance (SPR)), resulting in a detectable signal which can be used as an indication of real-time reactions between biological molecules.
  • the target molecule or test molecules are anchored to a solid phase, facilitating the detection of target molecule/test molecule complexes and separation of the complexes from free, uncomplexed molecules.
  • the target molecule or test molecule is immobilized to the solid support.
  • the target molecule is anchored to a solid surface, and the test molecule, which is not anchored, can be labeled, either directly or indirectly, with detectable labels discussed herein.
  • the attachment between a test molecule and/or target molecule and the solid support may be covalent or non-covalent (see, e.g., U.S.
  • the solid support may be one or more surfaces of the system, such as one or more surfaces in each well of a microtiter plate, a surface of a silicon wafer, a surface of a bead (see, e.g., Lam, Nature 354: 82-84 (1991)) that is optionally linked to another solid support, or a channel in a microfluidic device, for example.
  • Types of solid supports, linker molecules for covalent and non-covalent attachments to solid supports, and methods for immobilizing nucleic acids and other molecules to solid supports are well known (see, e.g., U.S. Patent Nos.
  • target molecule may be immobilized to surfaces via biotin and streptavidin.
  • biotinylated target polypeptide can be prepared from biotin-NHS (N- hydroxy-succinimide) using techniques known in the art (e.g., biotinylation kit, Pierce Chemicals, Rockford, IL), and immobilized in the wells of streptavidin-coated 96 well plates (Pierce Chemical).
  • a target polypeptide can be prepared as a fusion polypeptide.
  • glutathione-S-transferase/target polypeptide fusion can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, MO) or glutathione derivitized microtiter plates, which are then combined with a test molecule under conditions conducive to complex formation (e.g. , at physiological conditions for salt and pH). Following incubation, the beads or microtiter plate wells are washed to remove any unbound components, or the matrix is immobilized in the case of beads, and complex formation is determined directly or indirectly as described above. Alternatively, the complexes can be dissociated from the matrix, and the level of target molecule binding or activity is determined using standard techniques.
  • the non-immobilized component is added to the coated surface containing the anchored component. After the reaction is complete, unreacted components are removed (e.g., by washing) under conditions such that a significant percentage of complexes formed will remain immobilized to the solid surface.
  • the detection of complexes anchored on the solid surface can be accomplished in a number of manners. Where the previously non-immobilized component is pre- labeled, the detection of label immobilized on the surface indicates that complexes were formed.
  • an indirect lab l can be used to detect complexes anchored on the surface, e.g., by adding a labeled antibody specific for the immobilized component, where the antibody, in turn, can be directly labeled or indirectly labeled with, e.g., a labeled anti-Ig antibody.
  • an assay is performed utilizing antibodies that specifically bind target molecule or test molecule but do not interfere with binding of the target molecule to the test molecule. Such antibodies can be derivitized to a solid support, and unbound target molecule may be immobilized by antibody conjugation.
  • Methods for detecting such complexes include immunodetection of complexes using antibodies reactive with the target molecule, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the target molecule.
  • Cell free assays also can be conducted in a liquid phase.
  • reaction products are separated from unreacted components, by any of a number of standard techniques, including but not limited to: differential centrifugation (see, e.g., Rivas, G, and Minton, Trends Biochem Sci Aug; 18(8): 284-7 (1993)); chromatography (gel filtration chromatography, ion-exchange chromatography); electrophoresis (see, e.g., Ausubel et al, eds. Current Protocols in Molecular Biology , J. Wiley: New York (1999)); and immunoprecipitation (see, e.g, Ausubel et al, eds., supra).
  • differential centrifugation see, e.g., Rivas, G, and Minton, Trends Biochem Sci Aug; 18(8): 284-7 (1993)
  • chromatography gel filtration chromatography, ion-exchange chromatography
  • electrophoresis see, e.g., Ausubel et al, eds
  • a cell or cell free mixture is contacted with a candidate compound and the expression of target mRNA or target polypeptide is evaluated relative to the level of expression of target mRNA o>r target polypeptide in the absence of the candidate compound.
  • the candidate compound is identified as an agonist of target mRNA or target polypeptide expression.
  • the candidate compound is identified as an antagonist or inhibitor of target mRNA or target polypeptide expression.
  • the level of target rnRNA or target polypeptide expression can be determined by methods described herein.
  • binding partners that interact with a target molecule are detected.
  • the target molecules can interact with one or more cellular or extracellular macromolecules, such as polypeptides in vivo, and these interacting molecules are referred to herein as "binding partners.”
  • Binding partners can agonize or antagonize target molecule biological activity.
  • test mo lecules that agonize or antagonize interactions between target molecules and binding partners can be useful as therapeutic molecules as they can up-regulate or down-regulated target molecule activity in vivo and thereby treat osteoarthritis.
  • Binding partners of target molecules can be identified by methods known in the art.
  • binding partners may be identified by lysing cells and analyzing cell lysates by electrophoretic techniques.
  • a two-hybrid assay or three-hybrid assay can be utilized (see, e.g., U.S. Patent No. 5,283,317; Zervos et al, Cell 72:223-232 (1993); Madura et al, J. Biol. Chem. 2&8: 12046- 12054 (1993); Bartel et al, Biotechniques 14: 920-924 (1993); Iwabuchi et al, Oncogene 8: 1693-1696 (1993); and Brent WO94/10300).
  • a two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains.
  • the assay often utilizes two different DNA constructs.
  • a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B (sometimes referred to as the "bait") is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4).
  • a known transcription factor e.g., GAL-4
  • a DNA sequence from a library of DNA sequences that encodes a potential binding partner (sometimes referred to as the "prey") is fused to a gene that encodes an activation domain of the known transcription factor.
  • a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B can be fused to the activation domain. If the "bait” and the "prey” molecules interact in vivo, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene ⁇ .
  • a reaction mixture containing the target molecule and the binding partner is prepared, under conditions and for a time sufficient to allow complex formation.
  • the reaction mixture often is provided in the presence or absence of the test molecule.
  • the test molecule can be included initially in the reaction mixture, or can be added at a time subsequent to the addition of the target molecule and its binding partner. Control reaction mixtures are incubated without the test molecule or with a placebo.
  • Formation of any complexes between t e target molecule and the binding partner then is detected. Decreased formation of a complex in the rea-ction mixture containing test molecule as compared to in a control reaction mixture indicates that the molecule antagonizes target molecule/binding partner complex formation. Alternatively, increased formation of a complex in the reaction mixture containing test molecule as compared to in a control reaction mixture indicates that the molecule agonizes target molecule/binding partner complex formation. In another embodiment, complex formation of target molecule/binding partner can be compared to complex formation of mutant target molecule/binding partner (e.g., amino acid modifications in a target polypeptide).
  • mutant target molecule/binding partner e.g., amino acid modifications in a target polypeptide
  • the assays can be conducted in a heterogeneous or homogeneous format.
  • target molecule and/or the binding partner are immobilized to a solid phase, and complexes are detected on the solid phase at the end of the reaction.
  • homogeneous assays the entire reaction is carried out in a liquid phase.
  • the order of addition of reactants can be varied to obtain different information about the molecules being tested. For example, test compounds that agonize target molecule/binding partner interactions can be identified by conducting the reaction in the presence of the test molecule in a competition format.
  • test molecules that agonize preformed complexes e.g., molecules with higher binding constants that displace one of the components from the complex
  • the target molecule or the binding partner is anchored onto a solid surface (e.g., a microtiter plate), while the non-anchored species is labeled, either directly or indirectly.
  • the anchored molecule can be immobilized by non-covalent or covalent attachments.
  • an immobilized antibody specific for the molecule to be anchored can be used to anchor the molecule to the solid surface. The partner of the immobilized species is exposed to the coated surface with or without the test molecule.
  • any complexes formed will remain immobilized on the solid surface.
  • the detection of label immobilized on the surface is indicative of complex.
  • an indirect label can be used to detect complexes anchored to t ie surface; e.g., by using a labeled antibody specific for the initially non-immobilized species.
  • test compounds that inhibit complex formation or that disrupt preformed complexes can be detected.
  • the reaction can be conducted in a liquid phase in the presence or absence of test molecule, where the reaction products are separated from unreacted components, and the complexes are detected (e.g., using an immobilized antibody specific for one of the binding components to anchor any complexes formed in solution, and a labeled antibody specific for the other partner to detect anchored complexes).
  • test compounds that inhibit complex or that disrupt preformed complexes can be identified.
  • a homogeneous assay can be utilized. For example, a preformed complex of the target gene product and the interactive cellular or extracellular binding partner product is prepared.
  • One or both of the target molecule or binding partner is labeled, and the signal generated by the label(s) is quenched upon complex formation (e.g., U.S. Patent No. 4,109,496 that utilizes this approach for immunoassays).
  • Addition of a test molecule that competes with and displaces one of the species from the preformed complex will result in the generation of a signal above background. In this way, test substances that disrupt target molecule/binding partner complexes can be identified.
  • Candidate therapeutics for treating osteoarthritis are identified from a group of test molecules that interact with a target molecule.
  • Test molecules are normally ranked according to the degree with which they modulate (e.g., agonize or antagonize) a function associated with the target molecule (e.g., DNA replication and/or processing, RNA transcription and/or processing, polypeptide production and/or processing, and/or biological function/activity), and then top ranking modulators are selected. Also, pharmacogenomic information described herein can determine the rank of a modulator. The top 10% of ranked test molecules often are selected for further testing as candidate therapeutics, and sometimes the top 15%, 20%, or 25% of ranked test molecules are selected for further testing as candidate therapeutics.
  • Candidate therapeutics typically are formulated for administration to a subject.
  • Formulations and pharmaceutical compositions typically include in combination with a pharmaceutically acceptable carrier one or more target molecule modulators.
  • the modulator often is a test molecule identified as having an interaction with a target molecule by a screening method described above.
  • the modulator may be a compound, an antisense nucleic acid, a ribozyme, an antibody, or a binding partner.
  • formulations may comprise a target polypeptide or fragment thereof in combination with a pharmaceutically acceptable carrier, where the polypeptide or fragment sometimes has an APOL3 biological activity (e.g., apolipoprotein activity), and sometimes includes all or part of an apolipoprotein domain.
  • APOL3 biological activity e.g., apolipoprotein activity
  • Formulations or pharmaceutical compositions typically include in combination with a pharmaceutically acceptable carrier, a compound, an antisense nucleic acid, a ribozyme, an antibody, a binding partner that interacts with an ADAMTS2 polypeptide, ADAMTS2 nucleic acid, or a fragment thereof.
  • the formulated molecule may be one that is identified by a screening method described above.
  • formulations may comprise a ADAMTS2 polypeptide or fragment thereof, where the ADAMTS2 polypeptide contains an isoleucine at position 245 of SEQ ID NO: 44, and a pharmaceutically acceptable carrier.
  • formulations may comprise an active ADAMTS2 polypeptide or fragment thereof, where ADAMTS2 polypeptide fragments having activity are selected from amino acids 252- 1211, 253-1211, 254-1211, 255-1211, 256-1211, 257-1211, 258-1211, 259-1211 or 260-1211 of SEQ ID NO: 44, where it is understood that the active form of ADAMTS2 does not contain the propeptide domain.
  • pharmaceutically acceptable carrier includes solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. Supplementary active compounds can also be incorporated into the compositions.
  • the term "pharmaceutically acceptable carrier” includes solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. Supplementary active compounds can also be incorporated into the compositions. Pharmaceutical compositions can be included in a container, pack, or dispenser together with instructions for administration. [0181] A pharmaceutical composition typically is formulated to be compatible with its intended route of administration. Examples of routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, and rectal administration.
  • routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, and rectal administration.
  • Solutions or suspensions used for parenteral, intradermal, or subcutaneous application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerin, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose. pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide.
  • a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerin, propylene glycol or other synthetic solvents
  • antibacterial agents such as benzyl alcohol or methyl parabens
  • antioxidants
  • Oral compositions generally include an inert diluent or an edible carrier.
  • the active compound can be incorporated with excipients and used in the form of tablets, troches, or capsules, e.g., gelatin capsules.
  • Oral compositions can also be prepared using a fluid carrier for use as a mouthwash.
  • Pharmaceutically compatible binding agents, and/or adjuvant materials can be included as part of the composition.
  • the tablets, pills, capsules, troches and the like can contain any of the following ingredients, or compounds of a similar nature: a binder such as microcrystaUine cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring.
  • a binder such as microcrystaUine cellulose, gum tragacanth or gelatin
  • an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch
  • a lubricant such as magnesium stearate or Sterotes
  • a glidant such as colloidal silicon
  • compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion.
  • suitable carriers include physiological saline, bacteriostatic water, Cremophor ELTM (BASF, Parsippany, NJ) or phosphate buffered saline (PBS).
  • the composition must be sterile and should be fluid to the extent that easy syringability exists. It should be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi.
  • the carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof.
  • the proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants.
  • Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like.
  • Sterile injectable solutions can be prepared by incorporating the active compound in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization.
  • dispersions are prepared by incorporating the active compound into a sterile vehicle which contains a basic dispersion medium and the required other ingredients from those enumerated above.
  • the preferred methods of preparation are vacuum drying and freeze-drying which yields a powder of the active ingredient plus any additional desired ingredient from a previously sterile- filtered solution thereof.
  • the compounds are delivered in the form of an aerosol spray from pressured container or dispenser which contains a suitable propeUant, e.g., a gas such as carbon dioxide, or a nebulizer.
  • a suitable propeUant e.g., a gas such as carbon dioxide, or a nebulizer.
  • Systemic administration can also be by transmucosal or transdermal means.
  • penetrants appropriate to the barrier to be permeated are used in the formulation.
  • Such penetrants are generally known in the art, and include, for example, for transmucosal administration, detergents, bile salts, and fusidic acid derivatives.
  • Transmucosal administration can be accomplished through the use of nasal sprays or suppositories.
  • the active compounds are formulated into ointments, salves, gels, or creams as generally known in the art.
  • Molecules can also be prepared in the form of suppositories (e.g., with conventional suppository bases such as cocoa butter and other glycerides) or retention enemas for rectal delivery.
  • active molecules are prepared with carriers that will protect the compound against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems.
  • a controlled release formulation including implants and microencapsulated delivery systems.
  • Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art. Materials can also be obtained commercially from Alza Corporation and Nova Pharmaceuticals, Inc. Liposomal suspensions (including liposomes targeted to infected cells with monoclonal antibodies to viral antigens) can also be used as pharmaceutically acceptable carriers.
  • Dosage unit form refers to physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier.
  • Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD 50 (the dose lethal to 50% of the population) and the ED 50 (the dose therapeutically effective in 50% of the population).
  • the dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD 50 /ED 50 .
  • Molecules which exhibit high therapeutic indices are preferred. While molecules that exhibit toxic side effects may be used, care should be taken to design a delivery system that targets such compounds to the site of affected tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects.
  • the data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans.
  • the dosage of such molecules lies preferably within a range of circulating concentrations that include the ED 5 0 with little or no toxicity.
  • the dosage may vary within this range depending upon the dosage form employed and the route of administration utilized.
  • the therapeutically effective dose can be estimated initially from cell culture assays.
  • a dose may be formulated in animal models to achieve a circulating plasma concentration range that includes the IC 50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture.
  • IC 50 i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms
  • levels in plasma may be measured, for example, by high performance liquid chromatography.
  • a therapeutically effective amount of protein or polypeptide ranges from about 0.001 to 30 mg/kg body weight, sometimes about 0.01 to 25 mg/kg body weight, often about 0.1 to 20 mg/kg body weight, and more often about 1 to 10 mg/kg, 2 to 9 mg/kg, 3 to 8 mg/kg, 4 to 7 mg/kg, or 5 to 6 mg/kg body weight.
  • the protein or polypeptide can be administered one time per week for between about 1 to 10 weeks, sometimes between 2 to 8 weeks, often between about 3 to 7 weeks, and more often for about 4, 5, or 6 weeks.
  • treatment of a subject with a therapeutically effective amount of a protein, polypeptide, or antibody can include a single treatment or, preferably, can include a series of treatments.
  • polypeptide formulations featured herein is a method for treating osteoarthritis in a subject, which comprises contacting one or more cells in the subject with a first polypeptide, where the subject comprises a second polypeptide having one or more polymorphic variations associated with cancer, and where the first polypeptide comprises fewer polymorphic variations associated with cancer than the second polypeptide.
  • the first and second polypeptides are encoded by a nucleic acid which comprises a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence referenced in SEQ ID NO: 1-13 or referenced in Table B; a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B and a nucleotide sequence 90% or more identical to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B.
  • the subject often is a human.
  • a dosage of 0.1 mg/kg of body weight (generally 10 mg/kg to 20 mg/kg) is often utilized. If the antibody is to act in the brain, a dosage of 50 mg/kg to 100 mg/kg is often appropriate. Generally, partially human antibodies and fully human antibodies have a longer half-life within the human body than other antibodies. Accordingly, lower dosages and less frequent administration is often possible. Modifications such as lipidation can be used to stabilize antibodies and to enhance uptake and tissue penetration (e.g., into the brain). A method for lipidation of antibodies is described by Cruikshank et al, J. Acquired Immune Deficiency Syndromes and Human Retrovirology 14: 93 (1991).
  • Antibody conjugates can be used for modifying a given biological response, the drug moiety is not to be construed as limited to classical chemical therapeutic agents.
  • the drug moiety may be a protein or polypeptide possessing a desired biological activity.
  • Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a polypeptide such as tumor necrosis factor, alpha-interferon, beta-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 ("IL-1”), interleukin-2 (“IL-2”), interleukin-6 (“IL-6”), granulocyte macrophage colony stimulating factor (“GM-CSF”), granulocyte colony stimulating factor (“G-CSF”), or other growth factors.
  • a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin
  • a polypeptide such as tumor necrosis factor, alpha-interferon, beta-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator
  • an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Patent No. 4,676,980.
  • exemplary doses include milligram or microgram amounts of the compound per kilogram of subject or sample weight, for example, about 1 microgram per kilogram to about 500 milligrams per kilogram, about 100 micrograms per kilogram to about 5 milligrams per kilogram, or about 1 microgram per kilogram to about 50 micrograms per kilogram. It is understood that appropriate doses of a small molecule depend upon the potency of the small molecule with respect to the expression or activity to be modulated.
  • a physician, veterinarian, or researcher may, for example, prescribe a relatively low dose at first, subsequently increasing the dose until an appropriate response is obtained.
  • the specific dose level for any particular animal subject will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, gender, and diet of the subject, the time of administration, the route of administration, the rate of excretion, any drug combination, and the degree of expression or activity to be modulated.
  • gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (see, e.g., U.S. Patent 5,328,470) or by stereotactic injection (see e.g., Chen et al, (1994) Proc. Natl Acad. Sci. USA 97:3054-3057).
  • Pharmaceutical preparations of gene therapy vectors can include a gene therapy vector in an acceptable diluent, or can comprise a slow release matrix in which the gene delivery vehicle is imbedded.
  • the pharmaceutical preparation can include one or more cells which produce the gene delivery system. Examples of gene delivery vectors are described herein.
  • a therapeutic formulation described above can be administered to a subject in need of a therapeutic for inducing a desired biological response.
  • Therapeutic formulations can be administered by any of the paths described herein. With regard to both prophylactic and therapeutic methods of treatment, such treatments may be specifically tailored or modified, based on knowledge obtained from pharmacogenomic analyses described herein.
  • treatment is defined as the application or administration of a therapeutic formulation to a subject, or application or administration of a therapeutic agent to an isolated tissue or cell line from a subject with the purpose to cure, heal, alleviate, relieve, alter, remedy, ameliorate, improve or affect osteoarthritis, symptoms of osteoarthritis or a predisposition towards osteoarthritis.
  • a therapeutic formulation includes, but is not limited to, small molecules, peptides, antibodies, ribozymes and antisense oligonucleotides.
  • Administration of a therapeutic formulation can occur prior to the manifestation of symptoms characteristic of osteoarthritis, such that osteoarthritis is prevented or delayed in its progression.
  • the appropriate therapeutic composition can be determined based on screening assays described herein. [0199] As discussed, successful treatment of osteoarthritis can be brought about by techniques that serve to agonize target molecule expression or function, or alternatively, antagonize target molecule expression or function.
  • modulators include, but are not limited to, small organic or inorganic molecules; antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and Fab, F(ab') 2 and Fab expression library fragments, scFV molecules, and epitope-binding fragments thereof); and peptides, phosphopeptides, or polypeptides.
  • modulators include, but are not limited to, small organic or inorganic molecules; antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and Fab, F(ab') 2 and Fab expression library fragments, scFV molecules, and epitope-binding fragments thereof); and peptides, phosphopeptides, or polypeptides.
  • antisense and ribozyme molecules that inhibit expression of the target gene can also be used to reduce the level of target gene expression, thus effectively reducing the level
  • Antisense, ribozyme and triple helix molecules are discussed above. It is possible that the use of antisense, ribozyme, and/or triple helix molecules to reduce or inhibit mutant gene expression can also reduce or inhibit the transcription (triple helix) and/or translation (antisense, ribozyme) of mRNA produced by normal target gene alleles, such that the concentration of normal target gene product present can be lower than is necessary for a normal phenotype. In such cases, nucleic acid molecules that encode and express target gene polypeptides exhibiting normal target gene activity can be introduced into cells via gene therapy method.
  • nucleic acid molecules may be utilized in treating or preventing osteoarthritis.
  • Aptamers are nucleic acid molecules having a tertiary structure which permits them to specifically bind to ligands (see, e.g., Osborne, et al, Curr. Opin. Chem. Biol.1(1): 5-9 (1997); and Patel, D. J, Curr. Opin. Chem. Biol.
  • nucleic acid molecules for osteoarthritis treatment are gene therapy, which can also be referred to as allele therapy.
  • a gene therapy method for treating osteoarthritis in a subject which comprises contacting one or more cells in the subject or from the subject with a nucleic acid having a first nucleotide sequence (e.g., the first nucleotide sequence is identical to or substantially identical to a nucleotide sequence of SEQ ID NO: 1-13 or other nucleotide sequence referenced in Table B).
  • Genomic DNA in the subject comprises a second nucleotide sequence having one or more polymorphic variations associated with osteoarthritis (e.g., the second nucleotide sequence is identical to or substantially identical to a nucleotide sequence of SEQ ID NO: 1-13 or other nucleotide sequence referenced in Table B).
  • the first and second nucleotide sequences typically are substantially identical to one another, and the first nucleotide sequence comprises fewer polymorphic variations associated with osteoarthritis than the second nucleotide sequence.
  • the first nucleotide sequence may comprise a gene sequence that encodes a full-length polypeptide or a fragment thereof. The subject is often a human.
  • Allele therapy methods often are utilized in conjunction with a method of first determining whether a subject has genomic DNA that includes polymorphic variants associated with osteoarthritis.
  • the method often comprises supplementing arthritis-associated ADAMTS2 polypeptide with a non-arthritis-associated ADAMTS2 polypeptide or fragment thereof, where the non-arthritis-associated form of ADAMTS2 contains an isoleucine at position 245 of SEQ ID NO: 44 having enzymatic activity.
  • the arthritis-associated ADAMTS2 polypeptide sometimes contains a valine at position 245 of SEQ ID NO: 44 having an altered enzymatic activity varying from the non- arthritis-associated polypeptide.
  • a method of increasing the synthesis of procollagen II comprising providing or administering to individuals in need of increasing levels of type II collagen the pharmaceutical or physiologically acceptable composition comprising active human ADAMTS2 protein or fragment thereof, where ADAMTS2 polypeptide fragments having activity are selected from amino acids 252-1211, 253-1211, 254-1211, 255-1211, 256-1211, 257-1211, 258-1211, 259-1211 or 260-1211 of SEQ ID NO: 44, where it is understood that the active form of ADAMTS2 does not contain the propeptide domain.
  • a method of increasing the synthesis of procollagen II comprising providing or administering to individuals in need of increasing levels of type II collagen the pharmaceutical or physiologically acceptable composition comprising an enzyme or molecule capable of cleaving ADAMTS2 propeptide, e.g., a furin-type endopeptidase or N- ethylmaleimide described herein [02 6]
  • a method which comprises contacting one or more cells in the subject or from the subject with a polypeptide encoded by a nucleic acid having a first nucleotide sequence e.g.
  • the first nucleotide sequence is identical to or substantially identical to the nucleotide sequence of SEQ ID NO: 1-13 or other nucleotide sequence referenced in Table B).
  • Genomic DNA in the subject comprises a second nucleotide sequence having one or more polymorphic variations associated with osteoarthritis (e.g., the second nucleotide sequence is identical to or substantially identical to a nucleotide sequence of SEQ ID NO: 1-13 or other nucleotide sequence referenced in Table B).
  • the first and second nucleotide sequences typically are substantially identical to one another, and the first nucleotide sequence comprises fewer polymorphic variations associated with osteoarthritis than the second nucleotide sequence.
  • the first nucleotide sequence may comprise a gene sequence that encodes a full-length polypeptide or a fragment thereof.
  • the subject is often a human.
  • antibodies can be generated that are both specific for target molecules and that reduce target molecule activity. Such antibodies may be administered in instances where antagonizing a target molecule function is appropriate for the treatment of osteoarthritis.
  • stimulating antibody production in an animal or a human subject by injection with a target molecule is harmful to the subject, it is possible to generate an immune response against the target molecule by use of anti-idiotypic antibodies (see, e.g., Herlyn, Ann.
  • the smallest inhibitory fragment that binds to the target antigen is preferred.
  • peptides having an amino acid sequence corresponding to the Fv region of the antibody can be used.
  • single chain neutralizing antibodies that bind to intracellular target antigens can also be administered. Such single chain antibodies can be administered, for example, by expressing nucleotide sequences encoding single-chain antibodies within the target cell population (see, e.g., Marasco et al, Proc. Natl. Acad. Sci. USA 90: 7889-7893 (1993)).
  • Modulators can be administered to a patient at therapeutically effective doses to treat osteoarthritis.
  • a therapeutically effective dose refers to an amount of the modulator sufficient to result in amelioration of symptoms of osteoarthritis.
  • Toxicity and therapeutic efficacy of modulators can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD 50 (the dose lethal to 50% of the population) and the ED 50 (the dose therapeutically effective in 50%> of the population).
  • the dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD 5 0/ED 50 .
  • Modulators that exhibit large therapeutic indices are preferred. While modulators that exhibit toxic side effects can be used, care should be taken to design a delivery system that targets such molecules to the site of affected tissue in order to minimize potential damage to uninfected cells, thereby reducing side effects.
  • Data obtained from cell culture assays and animal studies can be used in formulating a range of dosages for use in humans.
  • the dosage of such compounds lies preferably within a range of circulating concentrations that include the ED 50 with little or no toxicity.
  • the dosage can vary within this range depending upon the dosage form employed and the route of administration utilized.
  • the therapeutically effective dose can be estimated initially from cell culture assays.
  • a dose can be formulated in animal models to achieve a circulating plasma concentration range that includes the IC 50 (i.e., the concentration of the test compound that achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans.
  • Levels in plasma can be measured, for example, by high performance liquid chromatography.
  • Another example of effective dose determination for an individual is the ability to directly assay levels of "free" and "bound" compound in the serum of the test subject. Such assays may utilize antibody mimics and/or "biosensors" that have been created through molecular imprinting techniques. Molecules that modulate target molecule activity are used as a template, or "imprinting molecule", to spatially organize polymerizable monomers prior to their polymerization with catalytic reagents. The subsequent removal of the imprinted molecule leaves a polymer matrix which contains a repeated "negative image" of the compound and is able to selectively rebind the molecule under biological assay conditions.
  • Such "imprinted" affinity matrixes can also be designed to include fluorescent groups whose photon-emitting properties measurably change upon local and selective binding of target compound. These changes readily can be assayed in real time using appropriate fiberoptic devices, in turn allowing the dose in a test subject to be quickly optimized based on its individual IC 50 .
  • An example of such a "biosensor” is discussed in Kriz et al, Analytical Chemistry 67: 2142-2144 (1995). [0213] The examples set forth below are intended to illustrate but not limit the invention.
  • SNPs proximal to the incident polymorphism in APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 and APOL3 regions were identified and allelotyped in OA case and control pools.
  • Methods are described for producing target polypeptides encoded by the nucleic acids of Table B in vitro or in vivo, which can be utilized in methods that screen test molecules for those that interact with target polypeptides. Test molecules identified as interactors with target polypeptides can be screened further as osteoarthritis therapeutics.
  • Blood samples were collected from individuals diagnosed with knee osteoarthritis, which were referred to as case samples. Also, blood samples were collected from individuals not diagnosed with knee osteoarthritis as gender and age-matched controls. A database was created that listed all phenotypic trait information gathered from individuals for each case and control sample. Genomic DNA was extracted from each of the blood samples for genetic analyses.
  • the solution was incubated at 37°C or room temperature if cell clumps were visible after mixing until the solution was homogeneous.
  • 2 ml of protein precipitation was added to the cell lysate.
  • the mixtures were vortexed vigorously at high speed for 20 sec to mix the protein precipitation solution uniformly with the cell lysate, and then centrifuged for 10 minutes at 3000 x g.
  • the supernatant containing the DNA was then poured into a clean 15 ml tube, which contained 7 ml of 100 ⁇ o isopropanol.
  • the samples were mixed by inverting the tubes gently until white threads of DNA were visible.
  • DNA was quantified by placing samples on a hematology mixer for at least 1 hour.
  • DNA was serially diluted (typically 1:80, 1 : 160, 1 :320, and 1 :640 dilutions) so that it would be within the measurable range of standards.
  • 125 ⁇ l of diluted DNA was transferred to a clear U-bottom microtitre plate, and 125 ⁇ l of IX TE buffer was transferred into each well using a multichannel pipette.
  • the DNA and IX TE were mixed by repeated pipetting at least 15 times, and then the plates were sealed. 50 ⁇ l of diluted DNA was added to wells A5-H12 of a black flat bottom microtitre plate.
  • the plate was placed into a Fluoroskan Ascent Machine (microplate fluorometer produced by Labsystems) and the samples were allowed to incubate for 3 minutes before the machine was run using filter pairs 485 nm excitation and 538 nm emission wavelengths. Samples having measured DNA concentrations of greater than 450 ng/ ⁇ l were re-measured for conformation. Samples having measured DNA concentrations of 20 ng/ ⁇ l or less were re-measured for confirmation.
  • a Fluoroskan Ascent Machine microplate fluorometer produced by Labsystems
  • samples for a pool were based upon the following criteria: the sample was derived from an individual characterized as Caucasian; the sample was derived from an individual of British paternal and maternal descent; case samples were derived from individuals diagnosed with specific knee osteoarthritis (OA) and were recruited from an OA knee replacement clinic. Control samples were derived from individuals free of OA, family history of OA, and rheumatoid arthritis. Also, sufficient genomic DNA was extracted from each blood sample for all allelotyping and genotyping reactions performed during the study.
  • OA knee osteoarthritis
  • Phenotype information from each individual was collected and included age of the individual, gender, family history of OA, general medical information (e.g., height, weight, thyroid disease, diabetes, psoriasis, hysterectomy), joint history (previous and current symptoms, joint-related operations, age at onset of symptoms, date of primary diagnosis, age of individual as of primary diagnosis and order of involvement), and knee-related findings (crepitus, restricted passive movement, bony swelling/deformity). Additional knee information included knee history, current symptoms, any major knee injury, menisectomy, knee replacement surgery, age of surgery, and treatment history (including hormone replace therapy (HRT)). Samples that met these criteria were added to appropriate pools based on disease status. [0220] The selection process yielded the pools set forth in Table 1, which were used in the studies that follow:
  • a whole-genome screen was performed to identify particular SNPs associated with occurrence of osteoarthritis. As described in Example 1, two sets of samples were utilized, which included samples from female individuals having knee osteoarthritis (osteoarthritis cases), and samples from female individuals not having knee osteoarthritis (female controls). The initial screen of each pool was performed in an allelotyping study, in which certain samples in each group were pooled. By pooling DNA from each group, an allele frequency for each SNP in each group was calculated. These allele frequencies were then compared to one another. Particular SNPs were considered as being associated with osteoarthritis when allele frequency differences calculated between case and control pools were statistically significant.
  • SNP disease association results obtained from the allelotyping study were then validated by genotyping each associated SNP across all samples from each pool. The results of the genotyping then were analyzed, allele frequencies for each group were calculated from the individual genotyping results, and a p-value was calculated to determine whether the case and control groups had statistically significant differences in allele frequencies for a particular SNP. When the genotyping results agreed with the original allelotyping results, the SNP disease association was considered validated at the genetic level.
  • a whole-genome SNP screen began with an initial screen of approximately 25,000 SNPs over each set of disease and control samples using a pooling approach. The pools studied in the screen are described in Example 1. The SNPs analyzed in this study were part of a set of 25,488 SNPs confirmed as being statistically polymorphic as each is characterized as having a minor allele frequency of greater than 10%.
  • the SNPs in the set reside in genes or in close proximity to genes, and many reside in gene exons. Specifically, SNPs in the set are located in exons, introns, and within 5,000 base- pairs upstream of a transcription start site of a gene.
  • SNPs were selected according to the following criteria: they are located in ESTs; they are located in Locuslink or Ensembl genes; and they are located in Genomatix promoter predictions. SNPs in the set were also selected on the basis of even spacing across the genome, as depicted in Table 2. [0223] A case-control study design using a whole genome association strategy involving approximately 28,000 single nucleotide polymorphisms (SNPs) was employed. Approximately 25,000 SNPs were evenly spaced in gene-based regions of the human genome with a median inter-marker distance of about 40,000 base pairs. Additionally, approximately 3,000 SNPs causing amino acid substitutions in genes described in the literature as candidates for various diseases were used.
  • the case- control study samples were of female Caucasian origin (British paternal and maternal descent) 670 individuals were equally distributed in two groups: female confrols and female cases.
  • the whole genome association approach was first conducted on 2 DNA pools representing the 2 groups. Significant markers were confirmed by individual genotyping.
  • a MassARRAYTM system (Sequenom, Inc.) was utilized to perform SNP genotyping in a high-throughput fashion. This genotyping platform was complemented by a homogeneous, single-tube assay method (hMETM or homogeneous MassEXTENDTM (Sequenom, Inc.)) in which two genotyping primers anneal to and amplify a genomic target surrounding a polymorphic site of interest. A third primer (the MassEXTENDTM primer), which is complementary to the amplified target up to but not inclu-ding the polymorphism, was then enzymatically extended one or a few bases through the polymorphic site and then terminated.
  • hMETM or homogeneous MassEXTENDTM homogeneous, single-tube assay method
  • a third primer (the MassEXTENDTM primer), which is complementary to the amplified target up to but not inclu-ding the polymorphism, was then enzymatically extended one or a few bases through the polymorph
  • SpectroDESIGNERTM software (Sequenom, Inc.) was used to generate a set of PCR primers and a MassEXTENDTM primer which where used to genotype the polymorphism.
  • Other primer design software could be used or one of ordinary skill in the art could manually design primers based on his or her knowledge of the relevant factors and considerations in designing such primers.
  • Table 3 shows PCR primers and Table 4 shows extension primers used for analyzing polymorphisms.
  • the initial PCR amplification reaction was performed in a 5 ⁇ l total volume containing IX PCR buffer with 1.5 mM MgCl 2 (Qiagen), 200 ⁇ M each of dATP, dGTP, dCTP, dTTP (Gibco-BRL), 2.5 ng of genomic DNA, 0.1 units of HotStar DNA polymerase (Qiagen), and 200 nM each of forward and reverse PCR primers specific for the polymorphic region of interest.
  • a primer extension reaction was initiated by adding a polymorphism-specific MassEXTENDTM primer cocktail to each sample.
  • Each MassEXTENDTM cocktail included a specific combination of dideoxynucleotides (ddNTPs) and deoxynucleotides (dNTPs) used to distinguish polymorphic alleles from one another.
  • ddNTPs dideoxynucleotides
  • dNTPs deoxynucleotides
  • the MassEXTENDTM reaction was performed in a total volume of 9 ⁇ l, with the addition of IX ThermoSequenase buffer, 0.576 units of ThermoSequenase (Amersham Pharmacia), 600 nM MassEXTENDTM primer, 2 mM of ddATP and/or ddCTP and/or ddGTP and/or ddTTP, and 2 mM of dATP or dCTP or dGTP or dTTP.
  • the deoxy nucleotide (dNTP) used in the assay normally was complementary to the nucleotide at the polymorphic site in the amplicon.
  • Samples were incubated at 94°C for 2 minutes, followed by 55 cycles of 5 seconds at 94°C, 5 seconds at 52°C, and 5 seconds at 72°C. [0230] Following incubation, samples were desalted by adding 16 ⁇ l of water (total reaction volume was 25 ⁇ l), 3 mg of SpectroCLEANTM sample cleaning beads (Sequenom, Inc.) and allowed to incubate for 3 minutes with rotation.
  • a second case control sample (replication sample #1) was created by using 100 Caucasian female cases from Chingford, UK, and 148 unrelated female cases from the St. Thomas twin study. Cases were defined as having Kellgren-Lawrence (KL) scores of at least 2 in at least one knee x-ray. In addition, 199 male knee replacement cases from Nottingham were included. (For a cohort description, see the Nottingham description provided in Example 1). The control pool was made up of unrelated female individuals from the St. Thomas twin study (England) with normal knee x-rays and without other indications of OA, regardless of anatomical location, as well as lacking family history of OA. The St.
  • KL Kellgren-Lawrence
  • Thomas twin study consists of Caucasian, female participants from the St. Thomas' Hospital, London, adult-twin registry, which is a voluntary registry of >4,000 twin pairs ranging from 18 to 76 years of age.
  • the replication sample 1 cohort was used to replicate the initial results.
  • Table 6 below summarizes the selected phenotype data collected from the case and control individuals.
  • a third case control sample was created by using individuals with symptoms of OA from Newfoundland, Canada. These individuals were recruited and examined by rheumatologists. Affected joints were x-rayed and a final diagnosis of definite or probable OA was made according to American College of Rheumatology criteria by a single rheumatologist to avoid any inter-examiner diagnosis variability. Controls were recruited from volunteers without any symptoms from the musculoskeletal system based on a normal joint exam performed by a rheumatologist. Only cases with a diagnosis of definite OA were included in the study. Only individuals of Caucasian origin were included. The cases consisted of 228 individuals with definite knee OA, 106 individuals with definite hip OA, and 74 individuals with hip OA.
  • Genonom, Inc. was utilized to perform SNP genotyping in a high-throughput fashion.
  • This genotyping platform was complemented by a homogeneous, single-tube assay method (hMETM or homogeneous MassEXTENDTM (Sequenom, Inc.)) in which two genotyping primers anneal to and amplify a genomic target surrounding a polymorphic site of interest.
  • a third primer (the MassEXTENDTM primer), which is complementary to the amplified target up to but not including the polymorphism, was then enzymatically extended one or a few bases through the polymorphic site and then terminated.
  • SpectroDESIGNERTM software (Sequenom, Inc.) was used to generate a set of PCR primers and a MassEXTENDTM primer which where used to genotype the polymorphism.
  • Other primer design software could be used or one of ordinary skill in the art could manually design primers based on his or her knowledge of the relevant factors and considerations in designing such primers.
  • Table 3 shows PCR primers and Table 4 shows extension probes used for analyzing (e.g., genotyping) polymorphisms in the replication cohorts.
  • the initial PCR amplification reaction was performed in a 5 ⁇ l total volume containing IX PCR buffer with 1.5 mM MgCl 2 (Qiagen), 200 ⁇ M each of dATP, dGTP, dCTP, dTTP (Gibco-BRL), 2.5 ng of genomic DNA, 0.1 units of HotStar DNA polymerase (Qiagen), and 200 nM each of forward and reverse PCR primers specific for the polymorphic region of interest. [0239] Samples were incubated at 95°C for 15 minutes, followed by 45 cycles of 95°C for 20 seconds, 56°C for 30 seconds, and 72°C for 1 minute, finishing with a 3 minute final extension at 72°C.
  • Each MassEXTENDTM cocktail included a specific combination of dideoxynucleotides (ddNTPs) and deoxynucleotides (dNTPs) used to distinguish polymorphic alleles from one another. Methods for verifying, allelotyping and genotyping SNPs are disclosed, for example, in U.S. Pat. No. 6,258,538, the content of which is hereby incorporated by reference. In Table 1, ddNTPs are shown and the fourth nucleotide not shown is the dNTP. [0241] The MassEXTENDTM reaction was performed in a total volume of 9 ⁇ l, with the addition of
  • MassEXTENDTM primer 2 mM of ddATP and/or ddCTP and/or ddGTP and/or ddTTP, and 2 mM of dATP or dCTP or dGTP or dTTP.
  • the deoxy nucleotide (dNTP) used in the assay normally was complementary to the nucleotide at the polymorphic site in the amplicon. Samples were incubated at
  • MALDI-TOF mass spectrometry (Biflex and Autoflex MALDI-TOF mass spectrometers (Bruker Daltonics) can be used) and SpecfroTYPER RTTM software (Sequenom, Inc.) were used to analyze and interpret the SNP genotype for each sample.
  • Genotyping results for replication cohorts #1 and #2 are provided in Tables 8 and 9, respectively.
  • PADI2 is a peptidyl arginine deiminase enzyme, type II, that converts arginine residues within proteins to citrulline residues.
  • This gene is one of four known PADI genes that encode enzymes that catalyze conversion of arginine to citrulline in proteins.
  • Individuals with rheumatoid arthritis (RA) frequently have autoantibodies to citrullinated peptides, suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes in RA (van Venrooij et al., Arthritis Res.;2(4):249-51. Epub 2000 May 24).
  • Pellino homo log 2 from Drosophila is a a member of the Pellino gene family, which are involved in Toll-like signalling pathways.
  • Pellino-2 associates with the pelle-like kinase/TL- lR-associated kinase protein to couple the pelle-like kinase/IL-lR-associated kinase protein to IL-1- or LPS-dependent signaling.
  • PELI2 may act as a downstream effector of " interleukin receptor signaling and may play a role in inflammation-mediated Osteoarthritis.
  • Pathway members downstream of PELI2 may be targetable ⁇ e.g., interleukin receptors).
  • G protein-coupled receptor 50 is a member of the G protein-coupled receptor family. GPR50 has significant homology to melatonin receptors and was isolated by PCR of human genomic DNA with degenerate primers based on conserved regions of melatonin receptors.
  • Example 4 APOB Proximal SNPs
  • rs 1367117 is associated with occurrence of osteoarthritis in subjects.
  • the polymorphic variant lies within the APOB gene and codes for a I98T amino acid change.
  • the guanine allele of SNP rsl367117 is associated with osteoarthritis (see Table 5) and codes for a threonine at position 98 (see, for example, amino acid sequence in SEQ ID NO: 38).
  • Apolipoprotein B is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL,).
  • ApoB binds to sulfated proteoglycans, especially chondroitin and dermatan sulfate, that are components of cartilage (Camejo et. al., Atherosclerosis. 1998 Aug;139(2):205-22). This may contribute to inflammation/joint damage by lipoprotein oxidation products. In addition, increased levels of ApoB is seen as a risk factor for osteonecrosis (Miyanishi et. al., Ann Rheum Dis. 1999 Aug;58(8):514-6) . Lipoprotein deposition has been noted in inflammatory (rheumatoid) arthritis and may play a role in inflammation mediated osteoarthritis.
  • ApoB function can be modulated by addition of an antibody or a decoy receptor for ApoB.
  • antibodies and small molecules that specifically interact withApoB are described in U.S. Patent Nos. 6,107,045; 6,309,844; 5,330,910; and 6,369,075.
  • One hundred twenty-two additional allelic variants proximal to rs 1367117 were identified and subsequently allelotyped in osteoarthritis case and control sample sets as described in Examples 1 and 2.
  • the polymorphic variants are set forth in Table 10.
  • the chromosome positions provided in column four of Table 10 are based on Genome "Build 34" of NCBFs GenBan .
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure IA for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group.
  • the minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure 1 A can be determined by consulting Table 13. For example, the left-most X on the left graph is at position 21188688.
  • Example 5 IL1RL2 Proximal SNPs [0257] It has been discovered that rsl024791, which lies within the IL1RL2 gene, is associated with occurrence of osteoarthritis in subjects. Interleukin-1 receptor-like 2 is a member of the interleukin 1 receptor family. IL1RL2 inhibits IL-1 activity and contains immmunoglobulin domains.
  • interleukin 1 receptor family genes including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (ILIRLI), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2ql2.
  • IL1RL2 may mediate inflammatory responses that can contribute to the development of OA.
  • IL1RL2 biological activity can be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant IL1RL2 protein or functional fragment thereof.
  • Allelotyping results from the discovery cohort are shown for cases and controls in Table 17.
  • the allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency.
  • Some SNPs are labeled "untyped” because of failed assays.
  • the IL1RL2 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 15 and 16.
  • the replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 18 and 19, respectively.
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure IB for the discovery cohort. The position of each SNP on ttie chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base lO) of the p- value comparing the estimated allele in the case group to that of the control group.
  • the minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure IB can be determined by consulting Table 17. For example, the left-most X on the left graph is at position 102409525.
  • ILIRLI Interleukin 1 receptor-like 1 isoform 1
  • Interleukin 1 receptor-like 1 isoform 1 is a member of the interleukin 1 receptor family with no known ligand (orphan receptor).
  • ILIRLI exists in both a soluble and transmembrane form, suggesting that it may have ligand or liga_nd scavenging activity.
  • Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli.
  • This gene and four other interleukin 1 receptor family genes form a cytokine receptor gene cluster.
  • interleukin 1 receptor type I (IL1R1)
  • interleukin 1 receptor type II (IL1R2)
  • interleukin 1 receptoir-like 2 IL1RL2
  • interleukin 18 receptor 1 IL18R1
  • the ILIRLI proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 21 and 22.
  • the replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 24 and 25, respectively.
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure IC for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group.
  • the minor allele frequency of the control group for each SNTP designated by an X or other symbol on the graphs in Figure IC can be determined by consulting Table 23. For example, the left-most X on the left graph is at position 102527857.
  • the black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10 "8 were truncated at that value. [0272] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
  • Example 7 WASPIP Region Proximal SNPs [0273] It has been discovered that rsl465621 in the untranslated region (UTR) of the WASPIP gene is associated with occurrence of osteoarthritis in subjects. This gene encodes a protein that plays a role in actin cytoskeleton organization. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Alternative transcript variants exist for this gene.
  • Biological activity of WASPIP or a pathway member downsfream of WASPIP can be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant WASPIP or downstream pathway member protein or functional fragment thereof.
  • the allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency.
  • the WASPIP proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 27 and 28.
  • the replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 30 and 31, respectively.
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure ID for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group.
  • the minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure ID can be determined by consulting Table 29. For example, the left-most X on the left graph is at position 175603909.
  • the black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01 , to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p- values that were less than 10 "s were truncated at that value. [0280] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
  • ADAMTS2 Region Proximal SNPs [0281] It has been discovered that SNP rs398829 is associated with occurrence of osteoarthritis in subjects. This gene encodes a disintegrin and metalloproteiixase with thrombospondin motifs-2 (ADAMTS2), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. ADAMT '-2 is involved in coUagens 1, 2 and 5 N-terminal processing, (type II collagen is the major form in cartilage).
  • ADAMT '-2 is involved in coUagens 1, 2 and 5 N-terminal processing, (type II collagen is the major form in cartilage).
  • the ADAMTS2 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 33 and 34.
  • the replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 36 and 37, respectively.
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure IE for the discovery cohort. The position of * each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group.
  • the minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure IE can be determined by consulting Table 35. For example, the left-most X on the left graph is at position 178695460.
  • BVES Proximal SNPs [0289] It was discovered that rs 1018810, an infronic SNP in the BVES gene, is associated with occurrence of osteoarthritis in subjects. BVES was identified as a blood vessel epicardial substance. Sequence analysis predicted 3 transmembrane helices with an extracellular C terminus. Northern blot analysis revealed that expression of an approximately 5.5-kb BVES transcript is restricted to skeletal muscle and adult and fetal heart. BVES is highly expressed in osteoarthritic cartilage according to EST database analysis, and may play a role in chondrocyte and/or bone cell development.
  • BVES biological activity may be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant BVES protein or functional fragment thereof.
  • allelic variants proximal to rs 1018810 were identified and subsequently allelotyped in osteoarthritis case and confrol sample sets as described in Examples 1 and 2.
  • the polymorphic variants are set forth in Table 38.
  • the chromosome positions provided in column four of Table 38 are based on Genome "Build 34" of NCBI's GenBank.
  • the allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency.
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure IF for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the confrol group.
  • the minor allele frequency of the confrol group for each SNP designated by an X or other symbol on the graphs in Figure IF can be determined by consulting Table 41. For example, the left-most X on the left graph is at position 105557091.
  • the black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10 "8 were truncated at that value. [0295] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
  • TM7SF3 Region Proximal SNPs [0296] It has been discovered that SNP rsl484086 in TM7SF3 is associated with occurrence of osteoarthritis in subjects.
  • TM7SF3 is an orphan receptor and is a member of the superfamily of 7- transmembrane domain proteins, one of the largest superfamilies of cell surface proteins. Members of this family include receptors for a variety of ligands, such as peptides, hormones, and ions, and for external sensory stimuli, such as odorants and light. Many 7-transmembrane molecules are able to recruit small G proteins, suggesting that they can transduce external signals to the cytoplasm.
  • the TM7SF3 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 43 and 44.
  • the replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 46 and 47, respectively.
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure IG for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis provides the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group.
  • the minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure IG can be determined by consulting Table 45. For example, the left-most X on the left graph is at position 27004780.
  • Example 11 LOXLl Region Proximal SNPs [0304] It has been discovered that rs8818 in the untranslated region (UTR) of the lysyl oxidase-like 1 (LOXLl) gene is associated with occurrence of osteoarthritis in subjects.
  • LOXLl is a Lysyl oxidase- like protein that catalyzes the cross-linking of collagen via lysine residues. Deficiency of the related protein, lysyl oxidase, causes a form of Ehlers-Danlos syndrome.
  • LOXLl likely is a secreted protein and its biological activity may be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant LOXLl protein or functional fragment thereof.
  • Fifty -eight additional allelic variants proximal to rs912428 were identified and subsequently allelotyped in osteoarthritis case and confrol sample sets as described in Examples 1 and 2.
  • the polymorphic variants are set forth in Table 48.
  • the chromosome positions provided in column four of Table 48 are based on Genome "Build 34" of NCBI's GenBank.
  • the allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and confrol pools, respectively, where "AF" is allele frequency.
  • the LOXLl proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 49 and 50.
  • the replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 52 and 53, respectively.
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure IH for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group.
  • the minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure IE can be determined by consulting Table 51. For example, the left-most X on the left graph is at position 71935363.
  • Example 12 CASPR4 Region Proximal SNPs
  • rs 1395486 in the cell recognition protein CASPR4 gene is associated with occurrence of osteoarthritis in subjects.
  • This gene product belongs to the neurexin family, members of which function in the nervous system as cell adhesion molecules and receptors.
  • C ⁇ SPR4 contains epidermal growth factor repeats and laminin G domains.
  • it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-li e domains, and thrombospondin N-terminal-like domains.
  • Alternative splicing of this gene results in 2 transcript variants encoding different isoforms.
  • CASPR4 biological activity can be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant CASPR4 protein or functional fragment thereof.
  • Fifty-six additional allelic variants proximal to rsl395486 were identified and subsequently allelotyped in osteoarthritis case and control sample sets as described in Examples 1 and 2.
  • the polymorphic variants are set forth in Table 54.
  • the chromosome positions provided in column four of Table 54 are based on Genome "Build 34" of NCBI's GenBank.
  • the CASPR4 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 55 and 56.
  • the replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 58 and 59, respectively.
  • allelotyping results were considered particularly significant witt a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated ira bold.
  • the allelotyping p- values were plotted in Figure II for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10 of the p-value comparing the estimated allele in the case group to that of the control group.
  • the minor allele frequency of the confrol group for each SNP designated by an X or other symbol on the graplxs in Figure II can be determined by consulting Table 57.
  • the left-most X on the left graph is at position 76177855.
  • the allele frequency associated with each symbol shown can be determined.
  • multiple lines have been added to the graph.
  • the broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01.
  • the vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs.
  • Two other lines are drawn to expose linear trends in the association of SNPs to the disease.
  • the generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models.
  • Th e black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10 "8 were truncated at that value.
  • Example 13 APOL3 Region Proximal SNPs [0320] It has been discovered that SNP rsl32659 in APOL3 is associated with occurrence of osteoarthritis in subjects. APOL3 belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. It has been shown that the APOL1-APOL4 gene cluster on chromosome 22 exists only in primates (humans and African green monkeys) and not in dogs, pigs, or rodents, suggesting that this gene cluster has arisen recently in evolution (Monajemi et.
  • APOL3 is genetically linked to OA and may play a role in the pathophysiology of OA. brought about by inflammation. APOL3 is likely inhibited by a small molecule inhibitor or by specific antibodies.
  • APOL3 activity may be increased in a subject by administering APOL3 recombinant protein or a functional fragment thereof.
  • APOL3 recombinant protein or a functional fragment thereof Two hundred-nineteen additional allelic variants proximal to rsl 32659 were identified and subsequently allelotyped in osteoarthritis case and confrol sample sets as described in Examples 1 and 2.
  • the polymorphic variants are set forth in Table 60.
  • the chromosome positions provided in column four of Table 60 are based on Genome "Build 34" of NCBI's GenBank. TABLE 60
  • the allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency.
  • the APOL3 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 61 and 62.
  • the replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 64 and 65, respectively. TABLE 64
  • allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold.
  • the allelotyping p- values were plotted in Figure 1 J for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis provides the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the confrol group.
  • the minor allele frequency of the control group for each STSTP designated by an X or other symbol on the graph in Figure 1 J can be determined by consulting Table 63. For example, the left-most X on the left graph is at position 34781551.
  • the black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10 -8 were truncated at that value.
  • Type II procollagen levels in osteoarthritic patients and autopsy controls is determined by radioimmunoassay (RIA) as previously described.
  • Allelic variations e.g., rs398829
  • genotyping See Examples 1 and 2.
  • Example 15 Effect of ADAMTS2 Polypeptides on Type II Collagen Processing Activity
  • recombinant polypeptides encompassing the ADAMTS2 variation of SEQ ID NO: 21 at position 733 and a wild-type ADAMTS2 polypeptide are expressed in cell lines such as chondrocytes.
  • ADAMTS2 pro-enzyme Since the allelic variation of ADAMTS2 at position 733 of SEQ ID: NO: 21 will prevent the conversion of the ADAMTS2 pro-enzyme to the catalytically active enzyme, processing of ADAMTS2 pro-enzyme is monitored by SDS-PAGE analysis followed by Western Blotting using antibodies to ADAMTS2 and methods common to someone skilled in the art. Reduced levels of pro- enzyme cleavage are apparent by the increased levels of immunopositive protein of higher molecular weight than of the cleaved active protein.
  • Example 16 Gene expression profiling in IL-1 beta and PMA stimulated SW1353 cells
  • the human chondrosarcoma cell line, SW1353, (ATCC HTB-94) was grown in L-15 media containing 10% FCS. Culture conditions were at 37 degrees with 0% CO2 with media changes every 2- 3 days.
  • SW1353 cells were grown to 80-90% confluence in 10 cm dishes and then stimulated with either lOng/ml IL-1 beta (human recombinant, Research Diagnostics) or with 200nm PMA (Sigma).
  • IL-1 beta stimulation was for 3 and 24 hours and PMA stimulation was for 3 and 24 hours. Control cells were grown and extracted in parallel with treated cells.
  • ILIRLI was seen to be upregulated by ILl-beta and by phorbol esters in a human chondrocyte cell line model (SW1353 monolayer cell line).
  • SW1353 monolayer cell line The expression profiling in IL-1 beta and PMA stimulated SW1353 cells grown in 3-D alginate cultures W1353 cells were cultured as above and then resupended in 1.2% alginate beads at a density of 4 millions cells/ml according to the manufacturer (Cambrex). Cells were grown for 2 weeks and an alginate bead was removed from culture and tested for the presence of proteoglycans by Alcian
  • ILIRLI was seen to be upregulated by ILl-beta and by phorbol esters in a human chondrocyte cell line model (SW1353 3-D alginate cell line).
  • RNA extraction and cDNA synthesis [0333] Cells from control chondrocytes and stimulated chondrocytes were isolated at the appropriate time period. mRNA "was isolated from total cell lysates using poly dT beads according to the manufacturer (Dynal). Isolated mRNA was used to generate cDNA using Superscript II reverse franscriptase according to the manufacturer (Invitrogen).
  • cDNA levels were normalized using the housekeeping gene, GAPDH.
  • Specific primers corresponding to MMP8 and MMP13 were used in semi-quantitative PCR as positive indicators of induction of an osteoarthritic phenotype. All specific primers used, including MMP8, MMP13, BVES, CHDCl and ILIRLI (transmembrane form, soluble form, soluble isoform 1 and soluble isoform 2) for semi-quantitative PCR and are listed in Table 66.
  • ILIRLI In a human chondrocyte cell line model, ILIRLI was seen to be upregulated by ILl-beta and by phorbol esters. ILIRLI has an unknown function, but it may possibly mediated inflammatory responses that can contribute to the development of OA. ILIRLI is druggable by antibodies or by protein agents.
  • cDNA is cloned into a pIVEX 2.3-MCS vector (Roche Biochem) using a directional cloning method.
  • a cDNA insert is prepared using PCR with forward and reverse primers having 5' resfriction site tags (in frame) and 5-6 additional nucleotides in addition to 3' gene-specific portions, the latter of which is typically about twenty to about twenty-five base pairs in length.
  • a Sal I resfriction site is infroduced by the forward primer and a Sma I restriction site is infroduced by the reverse primer.
  • PCR products are cut with the corresponding restriction enzymes (i.e., Sal I and Sma I) and the products are gel-purified.
  • the pIVEX 2.3-MCS vector is linearized using the same resfriction enzymes, and the fragment with the correct sized fragment is isolated by gel-purification.
  • Purified PCR product is ligated into the linearized pIVEX 2.3-MCS vector and E. coli cells transformed for plasmid amplification. The newly constructed expression vector is verified by restriction mapping and used for protein production.
  • coli lysate is reconstituted with 0.25 ml of Reconstitution Buffer, the Reaction Mix is reconstituted with 0.8 ml of Reconstitution Buffer; the Feeding Mix is reconstituted with 10.5 ml of Reconstitution Buffer; and the Energy Mix is reconstituted with 0.6 ml of Reconstitution Buffer.
  • 0.5 ml of the Energy Mix was added to the Feeding Mix to obtain the Feeding Solution.
  • 0.75 ml of Reaction Mix, 50 ⁇ l of Energy Mix, and 10 ⁇ g of the template DNA is added to the E. coli lysate.
  • the reaction device is turned upside-down and 10 ml of the Feeding Solution is loaded into the feeding compartment. All lids are closed and the reaction device is loaded into the RTS500 instrument. The instrument is run at 30°C for 24 hours with a stir bar speed of 150 rpm.
  • the pIVEX 2.3 MCS vector includes a nucleotide sequence that encodes six consecutive histidine amino acids on the C-terminal end of the target polypeptide for the purpose of protein purification.
  • Target polypeptide is purified by contacting the contents of reaction device with resin modified with Ni 2+ ions.
  • Target polypeptide is eluted from the resin with a solution containing free Ni 2+ ions.
  • Example 18 Cellular Production of Target Polypeptides
  • Nucleic acids are cloned into DNA plasmids having phage recombination cites and target polypeptides are expressed therefrom in a variety of host cells.
  • Alpha phage genomic DNA contains short sequences known as attP sites
  • E. coli genomic DNA contains unique, short sequences known as attB sites. These regions share homology, allowing for integration of phage DNA into E. coli via directional, site-specific recombination using the phage protein Int and the E. coli protein IHF. Integration produces two new art sites, L and R, which flank the inserted prophage DNA.
  • Phage excision from E. coli genomic DNA can also be accomplished using these two proteins with the addition of a second phage protein, Xis.
  • DNA vectors have been produced where the integration/excision process is modified to allow for the directional integration or excision of a target
  • a first step is to transfer the nucleic acid insert into a shuttle vector that contains attL sites surrounding the negative selection gene, ccdB (e.g. pENTER vector, Invitrogen, Inc.). This transfer process is accomplished by digesting the nucleic acid from a DNA vector used for sequencing, and to ligate it into the multicloning site of the shuttle vector, which will place it between the two attL sites while removing the negative selection gene ccdB.
  • a second method is to amplify the nucleic acid by the polymerase chain reaction (PCR) with primers containing attB sites. The amplified fragment then is integrated into the shuttle vector using Int and IHF.
  • PCR polymerase chain reaction
  • a third method is to utilize a topoisomerase- mediated process, in which the nucleic acid is amplified via PCR using gene-specific primers with the
  • the PCR amplified fragment can be cloned into the shuttle vector via the attL sites in the correct orientation.
  • the nucleic acid Once the nucleic acid is transferred into the shuttle vector, it can be cloned into an expression vector having attR sites.
  • vectors containing attR sites for expression of target polypeptide as a native polypeptide, N-fusion polypeptide, and C-fusion polypeptides are commercially available (e.g., pDEST (Invifrogen, Inc.)), and any vector can be converted into an expression vector for receiving a nucleic acid from the shuttle vector by introducing an insert having an attR site flanked by an antibiotic resistant gene for selection using the standard methods described above. Transfer of the nucleic acid from the shuttle vector is accomplished by directional recombination using Int, IHF, and Xis (LR clonase).
  • the desired sequence can be transferred to an expression vector by carrying out a one hour incubation at room temperature with Int, IHF, and Xis, a ten minute incubation at 37°C with proteinase K, transforming bacteria and allowing expression for one hour, and then plating on selective media. Generally, 90% cloning efficiency is achieved by this method.
  • expression vectors are pDEST 14 bacterial expression vector with att7 promoter, pDEST 15 bacterial expression vector with a T7 promoter and a N-terminal GST tag, pDEST 17 bacterial vector with a T7 promoter and a N- terminal polyhistidine affinity tag, and pDEST 12.2 mammalian expression vector with a CMV promoter and neo resistance gene. These expression vectors or others like them are transformed or transfected into cells for expression of the target polypeptide or polypeptide variants. These expression vectors are often transfected, for example, into murine-transformed a adipocyte cell line 3T3-L1, (ATCC), human embryonic kidney cell line 293, and rat cardiomyocyte cell line H9C2.
  • the "Contig Position” provided in Table B corresponds to a nucleotide position set forth in the contig sequence (see “Contig Accession No.”), and designates the polymorphic site corresponding to the SNP reference number.
  • the sequence containing the polymorphisms also may be referenced by the "Nucleotide Accession No.” set forth in Table B.
  • the "Sequence Identification” corresponds to cDNA sequence that encodes associated target polypeptides (e.g., PADI2).
  • the position of the SNP within the cDNA sequence is provided in the "Sequence Position” column of Table B. If the SNP falls within an exon, the corresponding amino acid position (and amino acid change, if applicable) is provided as well. The amino acid found to be associated with OA is in bold. Also, the allelic variation at the polymorphic site and the allelic variant identified as associated with osteoarthritis is specified in Table B. All nucleotide and polypeptide sequences referenced and accessed by the parameters set forth in Table B are incorporated herein by reference.
  • Genomic nucleotide sequences for PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CNTNAP4 / CASPR4 andAPOL3 regions are set forth in SEQ ID NO: 1-13, respectively.
  • genomic nucleotide sequences for a PADI2 region (SEQ ID NO: 1), a APOB region (SEQ ID NO: 2), a IL1RL2 region (SEQ ID NO: 3), a ILIRLI region (SEQ ID NO: 4), a WASPIP region (SEQ D NO: 5), a ADAMTS2 region (SEQ ID NO: 6), a Rr ⁇ S region (SEQ ID NO: 7), a TM7SF3 region (SEQ ID NO: 8), a P- ⁇ X ⁇ region (SEQ ID NO: 9), a ZQZZJ region (SEQ ID NO: 10), a CNTNAP4 / CASPR4 region (SEQ ID NO: 11), a GPR50 region (SEQ ID NO: 12), and aAPOL3 region (SEQ ID NO: 13).
  • A or "a” is adenosine, adenine, or adenylic acid
  • C or “c” is cytidine, cytosine, or cytidylic acid
  • G or “g” is guanosine, guanine, or guanylic acid
  • T or “t” is thymidine, thymine, or thymidylic acid
  • I or “i” is inosine, hypoxanthine, or inosinic acid.
  • SNPs are designated by the following convention: “R” represents A or G, “M” represents A or C; “W” represents A or T; “Y” represents C or T; “S” represents C or G; "K” represents G or T; "V represents A, C or G; “H” represents A, C, or T; “D” represents A, G, or T; "B” represents C, G, or T; and "N” represents A, G, C, or T.
  • gaggcctccc cagtcatgct ttctgtactg cctgaggaac cataagctga ttaaacctct

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Abstract

Provided herein are methods for identifying a risk of osteoarthritis in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating osteoarthritis, and therapeutic and preventative methods applicable to osteoarthritis. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

Description

METHODS FOR IDENTIFYING RISK OF OSTEOARTHRITIS AND TREATMENTS THEREOF
Field of the Invention [0001] The invention relates to genetic methods for identifying risk of osteoarthritis and treatments that specifically target such diseases.
Background [0002] Osteoarthritis (OA) is a chronic disease usually affecting weight-bearing synovial joints. There are approximately 20 million Americans affected by OA and it is the leading cause of disability in the United States. In addition to extensive human suffering, OA also accounts for nearly all knee replacements and more than half of all hip replacements in the United States. Despite its prevalence, OA is poorly understood and there are few treatments available besides anti-inflammatory drugs and joint replacement. [0003] Osteoarthritis (OA) is a disease caused by degeneration of articular cartilage and subsequent joint deformation. In addition to risk factors like body weight, joint injury and age, there is a strong hereditary component to OA, reflected by high heritability estimates from twin studies. So far, few- of the genes responsible for this genetic component have been identified.
Summary [0004] It has been discovered that certain polymorphic variations in human genomic DNA are associated with osteoarthritis. In particular, polymorphic variants in loci containing PADI2, APOB; IL1RL2, IL1RL1, WASPIP, ADAMTS2, BVES, TM7SF3, LOXL1, CASPR4 andAPOL3 regions and other regions in Table B of human genomic DNA have been associated with risk of osteoarthritis. [0005] Thus, featured herein are methods for identifying a subject at risk of osteoarthritis and/or a risk of osteoarthritis in a subject, which comprise detecting the presence or absence of one or more polymorphic variations associated with osteoartliritis in or around the loci described herein in a human nucleic acid sample. In an embodiment, two or more polymorphic variations are detected in two or more regions of which one is the PADI2, APOB, IL1RL2, IL1RL1, WASPIP, ADAMTS2, BVES, TM7SF3, LOXL1, CASPR4 or APOL3 region or other region in Table B. In certain embodiments, 3 or more, or 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 or more polymorphic variants are detected. [0006] Also featured are nucleic acids that include one or more polymorphic variations associated with occurrence of osteoarthritis, as well as polypeptides encoded by these nucleic acids. In addition, provided are methods for identifying candidate therapeutic molecules for treating osteoarthritis, as well as methods for treating osteoarthritis in a subject by identifying a subject at risk of osteoarthritis and treating the subject with a suitable prophylactic, treatment or therapeutic molecule. [0007] Also provided are compositions comprising a cell from a subject having osteoarthritis or at risk of osteoarthritis and/or a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 oτAPOL3 nucleic acid or other nucleic acid referenced in Table B, with a RNAi, siRNA, antisense DNA or RNA, or ribozyme nucleic acid designed from a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B. In an embodiment, the RNAi, siRNA, antisense DNA or RNA, or ribozyme nucleic acid is designed from a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B that includes one or more polymorphic variations associated with osteoarthritis, and in some instances, specifically interacts with such a nucleotide sequence. Further, provided are arrays of nucleic acids bound to a solid surface, in which one or more nucleic acid molecules of the array have a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a fragment or substantially identical nucleic acid thereof, or a complementary nucleic acid of the foregoing. Featured also are compositions comprising a cell from a subject having osteoartliritis or at risk of osteoarthritis and/or a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 polypeptide or other polypeptide referenced in Table B, with an antibody that specifically binds to the polypeptide. In an embodiment, the antibody specifically binds to an epitope in the polypeptide that includes a non-synonymous amino acid modification associated with osteoarthritis (e.g., results in an amino acid substitution in the encoded polypeptide associated with osteoarthritis). In certain embodiments, the antibody selectively binds to an epitope in the PADI2, APOB, IL1RL2, ILIRLI, WASPIP, AOAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 polypeptide, or other polypeptide referenced in Table B, having an amino acid associated with osteoarthritis. Thus, featured is an antibody that binds an epitope having an amino acid encoded by rsl367117, rsl041973 and/or rs398829, such as a isoleucine or threonine encoded by rsl 367117 (e.g., a threonine at position 98 in an APOB polypeptide), a glutamic acid or alanine encoded by rsl041973 (e.g., an alanine at position 78 in a ILIRLI polypeptide), a valine or isoleucine encoded by rs398829 (e.g., a valine at position 245 in a ADAMTS2 polypeptide), at the corresponding position in the polypeptide.
Brief Description of the Drawings [0008] Figures 1A-1J show proximal SNPs in a 100-kb window in PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 αndAPOL3 regions of genomic DNA, respectively, that were compared between pools of cases and controls. The x-axis corresponds to their chromosomal position and the y-axis to the test P-values (shown on the -log10 scale). The continuous bold line presents the results of a goodness-of-fit test for an excess of significance (compared to 0.05) in a 10 kb sliding window assessed at 1 kb increments. Detailed Description [0009] It has been discovered that polymorphic variants in a locus containing a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 region are associated with occurrence of osteoarthritis in subjects. Thus, detecting genetic determinants associated with an increased risk of osteoarthritis occurrence can lead to early identification of a predisposition to osteoarthritis and early prescription of preventative measures. Also, associating a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 polymorphic variant and other variants referenced in Table B with osteoarthritis has provided new targets for screening molecules useful in treatments of osteoarthritis. Osteoarthritis and Sample Selection [0010] Osteoarthritis (OA), or degenerative joint disease, is one of the oldest and most common types of arthritis. It is characterized by the breakdown of the joint's cartilage. Cartilage is the part of the joint that cushions the ends of bones, and its breakdown causes bones to rub against each other, causing pain and loss of movement. Type II collagen is the main component of cartilage, comprising 15-25% of the wet weight, approximately half the dry weight, and representing 90-95% of the total collagen content in the tissue. It forms fibrils that endow cartilage with tensile strength (Mayne, R. Arthritis Rhuem. 32:241-246 (1989)). [0011] Most commonly affecting middle-aged and older people, OA can range from very mild to very severe. It affects hands and weight-bearing joints such as knees, hips, feet and the back. Knee OA can be as disabling as any cardiovascular disease except stroke. [0012] Osteoarthritis affects an estimated 20.7 million Americans, mostly after age 45, with women more commonly affected than men. Physicians make a diagnosis of OA based on a physical exam and history of symptoms. X-rays are used to confirm diagnosis. Most people over 60 reflect the disease on X-ray, and about one-third have actual symptoms. [0013] There are many factors that can cause OA. Obesity may lead to osteoarthritis of the knees. In addition, people with joint injuries due to sports, work-related activity or accidents may be at increased risk of developing OA. [0014] Genetics has a role in the development of OA too. Some people may be born with defective cartilage or with slight defects in the way that joints fit together. As a person ages, these defects may cause early cartilage breakdown in the joint or the inability to repair damaged or deteriorated cartilage in the joint. [0015] Inclusion or exclusion of samples for an osteoarthritis pool may be based upon the following criteria: ethnicity (e.g., samples derived from an individual characterized as Caucasian); parental ethnicity (e.g., samples derived from an individual of British paternal and maternal descent); relevant phenotype information for the individual (e.g., case samples derived from individuals diagnosed with specific knee, hand or hip osteoarthritis (OA); case samples recruited from an OA knee replacement clinic). Control samples may be selected based on relevant phenotype information for the individual (e.g., derived from individuals free of OA at several sites (knee, hand, hip etc)); and no family history of OA and/or rheumatoid arthritis. Additional phenotype information collected for both cases and controls may include age of the individual, gender, family history of OA, diagnosis with osteoarthritis (joint location of OA (e.g., knee, hips, hands and spine), date of primary diagnosis, age of individual as of primary diagnosis), knee history (current symptoms, any major knee injury, menisectomy, knee replacement surgery, age of surgery), HRT history, osteoporosis diagnosis. [0016] Based in part upon selection criteria set forth above, individuals having osteoarthritis can be selected for genetic studies. Also, individuals having no history of osteoarthritis often are selected for genetic studies, as described hereafter.
Polymorphic Variants Associated with Osteoarthritis [0017] A genetic analysis provided herein linked osteoarthritis with polymorphic variant nucleic acid sequences in the human genome. As used herein, the term "polymorphic site" refers to a region in a nucleic acid at which two or more alternative nucleotide sequences are observed in a significant number of nucleic acid samples from a population of individuals. A polymorphic site may be a nucleotide sequence of two or more nucleotides, an inserted nucleotide or nucleotide sequence, a deleted nucleotide or nucleotide sequence, or a microsatellite, for example. A polymorphic site that is two or more nucleotides in length may be 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or more, 20 or more, 30 or more, 50 or more, 75 or more, 100 or more, 500 or more, or about 1000 nucleotides in length, where all or some of the nucleotide sequences differ within the region. A polymorphic site is often one nucleotide in length, which is referred to herein as a "single nucleotide polymorphism" or a "SNP." [0018] Where there are two, three, or four alternative nucleotide sequences at a polymorphic site, each nucleotide sequence is referred to as a "polymorphic variant" or "nucleic acid variant." Where two polymorphic variants exist, for example, the polymorphic variant represented in a minority of samples from a population is sometimes referred to as a "minor allele" and the polymorphic variant that is more prevalently represented is sometimes referred to as a "major allele." Many organisms possess a copy of each chromosome (e.g., humans), and those individuals who possess two major alleles or two minor alleles are often referred to as being "homozygous" with respect to the polymorphism, and those individuals who possess one major allele and one minor allele are normally referred to as being "heterozygous" with respect to the polymorphism. Individuals who are homozygous with respect to one allele are sometimes predisposed to a different phenotype as compared to individuals who are heterozygous or homozygous with respect to another allele. [0019] In genetic analysis that associate polymorphic variants with osteoarthritis, samples from individuals having osteoarthritis and individuals not having osteoarthritis often are allelotyped and/or genotyped. The term "allelotype" as used herein refers to a process for determining the allele frequency for a polymorphic variant in pooled DNA samples from cases and controls. By pooling DNA from each group, an allele frequency for each SNP in each group is calculated. These allele frequencies are then compared to one another. The term "genotyped" as used herein refers to a process for determining a genotype of one or more individuals, where a "genotype" is a representation of one or more polymorphic variants in a population. [0020] A genotype or polymorphic variant may be expressed in terms of a "haplotype," which as used herein refers to two or more polymorphic variants occurring within genomic DNA in a group of individuals within a population. For example, two SNPs may exist within a gene where each SNP position includes a cytosine variation and an adenine variation. Certain individuals in a population may carry one allele (heterozygous) or two alleles (homozygous) having the gene with a cytosine at each SNP position. As the two cytosines corresponding to each SNP in the gene travel together on one or both alleles in these individuals, the individuals can be characterized as having a cytosine/cytosine haplotype with respect to the two SNPs in the gene. [0021] As used herein, the term "phenotype" refers to a trait which can be compared between individuals, such as presence or absence of a condition, a visually observable difference in appearance between individuals, metabolic variations, physiological variations, variations in the function of biological molecules, and the like. An example of a phenotype is occurrence of osteoarthritis. [0022] Researchers sometimes report a polymorphic variant in a database without determining whether the variant is represented in a significant fraction of a population. Because a subset of these reported polymorphic variants are not represented in a statistically significant portion of the population, some of them are sequencing errors and/or not biologically relevant. Thus, it is often not known whether a reported polymorphic variant is statistically significant or biologically relevant until the presence of the variant is detected in a population of individuals and the frequency of the variant is determined. Methods for detecting a polymorphic variant in a population are described herein, specifically in Example 2. A polymorphic variant is statistically significant and often biologically relevant if it is represented in 5% or more of a population, sometimes 10%) or more, 15% or more, or 20% or more of a population, and often 25% or more, 30% or more, 35% or more, 40% or more, 45% or more, or 50% or more of a population. [0023] A polymorphic variant may be detected on either or both strands of a double-stranded nucleic acid. Also, a polymorphic variant may be located within an intron or exon of a gene or within a portion of a regulatory region such as a promoter, a 5' untranslated region (UTR), a 3' UTR, and in DNA (e.g., genomic DNA (gDNA) and complementary DNA (cDNA)), RNA (e.g., mRNA, tRNA, and rRNA), or a polypeptide. Polymorphic variations may or may not result in detectable differences in gene expression, polypeptide structure, or polypeptide function. [0024] It was determined that polymorphic variations associated with an increased risk of osteoarthritis existed in SEQ ID NO: 1-13 or a nucleotide sequence referenced in Table B. In certain embodiments, polymorphic variants at positions rs910223, rs 1367117, rs 1024791, rs 1041973, rsl465621, rs398829, rsl018810, rsl484086, rs242392, rs8818, rsl395486, rs512294 and/or rsl32659 in the human genome were associated with an increased risk of osteoarthritis, and in specific embodiments, the corresponding allele in the right-most column in Table B for each position is associated with an increased risk of osteoarthritis. In other embodiments polymorphic variants at positions rsl367117, rsl041973 and rs398829 were associated with an increased risk of osteoarthritis, and in specific embodiments, a threonine encoded by rs 1367117, an alanine encoded by rs 1041973, and a valine encoded by rs398829 were associated with an increased risk of osteoartliritis. [0025] Polymorphic variants in and around the APOB locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 2 selected from the group consisting of 238, 294, 295, 347, 1425, 4891, 5087, 7041, 7121, 7219, 7443, 7485, 10939, 11367, 11571, 11839, 12551, 12646, 13469, 14913, 15205, 15246, 15695, 17473, 17610, 17828, 18130, 18281, 18623, 18890, 21561, 23100, 23872, 24581, 24582, 24983, 27540, 30846, 31415, 31453, 31899, 37000, 38681, 39287, 42951, 45648, 46222, 46687, 47020, 47593, 48513, 49723, 49986, 53018, 53296, 53547, 53899, 53916, 53933, 54305, 55327, 55895, 56143, 56640, 58486, 59576, 63048, 64008, 64018, 64859, 65995, 66905, 67183, 67942, 68101, 68521, 68664, 68988, 69178, 72143, 74183, 74312, 74407, 75518, 76153, 77398, 77615, 79092, 80000, 80125, 80595, 81061, 81151, 81918, 83072, 83137, 83235, 83263, 83279, 83280, 83533, 86856, 87186, 87189, 87727, 87978, 89129, 89556, 89702, 90233, 93060, 94779, 95367, 95844, 95942, 96884 , 96938, 97627, 97777, 97871, 98746 and 99663. Polymorphic variants at the following positions in SEQ ID NO: 2 in particular were associated with an increased risk of osteoarthritis: 7219, 7485, 11839, 31899, 37000, 48513, 49986, 56640, 74407, 77398, 93060 and 97627. In particular, the following polymorphic variants in SEQ ID NO: 2 were associated with risk of osteoarthritis: an adenine at position 7219, a guanine at position 7485, an adenine at position 11839, a thymine at position 31899, an adenine at position 37000, a cytosine at position 48513, a guanine at position 49986, a guanine at position 56640, a cytosine at position 74407, a guanine at position 77398, an adenine at position 93060 and an adenine at position 97627. A threonine at amino acid position 98 in an APOB polypeptide was associated with increased risk of osteoarthritis (i.e., an isoleucine to threonine non-synonymous variation). [0026] Polymorphic variants in and around the IL1RL2 locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 3 selected from the group consisting of 225, 509, 860, 874, 939, 1483, 1798, 2189, 2215, 2282, 2340, 2963, 3369, 3481, 3564, 3653, 4860, 4941, 4975, 5321, 5346, 5541, 5633, 6007, 6317, 6378, 6382, 6426, 6479, 6641, 6703, 6705, 7963, 8525, 8526, 8598, 8624, 8883, 8980, 13578, 16135, 16141, 16642, 16931, 17004, 17009, 17010, 18713, 18853, 20783, 21335, 22180, 22268, 22285, 25378, 25906, 26015, 26475, 26798:
27042, 27649, 27827, 27873: 28122, 28202, 28232, 28240, 29546, 29748, 30054, 30646, 31149, 36912; 36936, 37184, 39064, 39343: 40868, 40917, 41113, 47343, 47806, 47911, 48009, 48621, 49245, 49247 49299, 49302, 49514, 49626 49791, 50010, 50294, 51482, 51556, 51855, 51956 ,52155, 52448, 52458 52511, 52607, 54049, 54224 54567, 55052, 55857, 55941, 56120, 56349, 56727, 57232, 58806, 61181 63808, 64526, 64865, 64928 64966, 65080, 65690, 66228, 66982, 72511, 74170, 74264, 74333, 74502; 74741, 75321, 82558, 85366 85469, 86485, 87687, 89463, 89660, 95718 and 95821. Polymorphic variants at the following positions in SEQ ID NO: 3 in particular were associated with an increased risk of osteoarthritis: 2215, 3369, 16642, 20783, 52155, 55052, 55941, 74333, 74741, 85366, 85469, 87687, 89660 and 95718, where specific embodiments are directed to position 52155. In particular, the following polymorphic variants in SEQ ID NO: 3 were associated with risk of osteoarthritis: an adenine at position 2215, a deletion at position 3369, a deletion at position 16642, a cytosine at position 20783, a cytosine at position 52155, a cytosine at position 55052, a cytosine at position 55941, a thymine at position 74333, an adenine at position 74741, a deletion at position 85366, a thymine at position 85469, a thymine at position 87687, an adenine at position 89660 and a cytosine at position 95718. [0027] Polymorphic variants in and around the ILIRLI locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 4 selected from the group consisting of 207, 6019, 6414, 7341, 10984, 12351, 13335, 16584, 16737, 23897, 24057, 25145, 25300, 26262, 26312, 26589, 27302, 27358, 27451, 27552, 30731, 32085, 32139, 33184, 42382, 42569, 44823, 45217, 45548, 45601, 45722, 45967 ,47367, 47642, 48126, 49218, 49274, 49433, 49610, 51282, 51466, 53757, 53960, 54031, 54574, 55679, 56100, 56182, 59817, 60533, 60656, 72209, 72778, 74293, 77335, 78029, 78374, 78421, 78434, 79174, 79397, 79562, 79700, 79730, 79904, 79920, 79938, 79972, 80125, 80368, 83484, 85536, 85829, 86425, 88083, 88770, 90622, 90924, 91634, 92029, 95152, 95348, 96145, 96793, 97015, 97064, 97711, 97855 and 98708. Polymorphic variants at the following positions in SEQ ID NO: 4 in particular were associated with an increased risk of osteoarthritis: 6414, 51282, 54574, 78374, 92029 and 96793, where specific embodiments are directed to position 54574. In particular, the following polymorphic variants in SEQ ID NO: 4 were associated with risk of osteoarthritis: an adenine at position 6414, an adenine at positoin 51282, a cytosine at position 54574, a thymine at position 92029 and an adenine at position 96793. [0028] Polymorphic variants in and around the WASPIP locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 5 selected from the group consisting of 209, 5908, 7460, 7733, 7855, 7904, 8869, 9480, 13820, 15152, 17713, 17804, 18220, 19083, 19123, 19605, 20247, 20592, 21907, 23273, 23299, 23623, 23669, 23844, 24190, 24486, 24896, 25118, 30551, 30844, 30900, 30942, 31699, 32081, 35078, 36196, 36541, 38356, 45578, 49634, 49774, 51119, 51181, 51652, 54467, 55762, 55999, 57865, 66613, 68377, 69754, 72859, 76512, 76717, 77722, 80998, 82033, 89658, 89960, 94155 and 95679. Polymorphic variants at the following positions in SEQ ID NO: 5 in particular were associated with an increased risk of osteoarthritis: 19083, 30900, 38356, 76512 and 94155, where specific embodiments are directed to positions 30900, 76512 and/or 94155. In particular, the following polymorphic variants in SEQ ID NO: 5 were associated with risk of osteoarthritis: a thymine at position 19083, a guanine at position 30900, an adenine at position 38356, an adenine at position 76512 and an adenine at position 94155. [0029] Polymorphic variants in and around the ADAMTS2 locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 6 selected from the group consisting of 210, 3608, 3609, 4318, 5593, 5629, 5639, 5640, 8943, 17968, 19887, 21034, 21085, , 21596, 23379, 23432, 24007, 26121, 26273, 26755, 27411, 27710, 27842, 28379, 29603, 31232, 31504, 32583, 32794, 32840, 33044, 33150, 33218, 33513, 33959, 34486, 36289, 36570, 38247, 38477, 38518, 38529, 38667, 39781, 39856, 39927, 40506, 41869, 42452, 44788, 46059, 46846, 47712, 48796, 49441, 49602, 49723, 50050, 50171, 50477, 50818, 50833, 50881, 50882, 51386, 51534, 52317, 52368, 52970, 53023, 53356, 53882, 54553, 55475, 55530, 55691, 55848, 55879, 56316, 56911, 57320, 57391, 57437, 57478, 57500, 59111, 59333, 59715, 59804, 59851, 59929, 60052, 60240, 60359, 60381, 60456, 60724, 60875, 60968, 60978, 60998, 61557, 62091, 62645, 62943, 63131, 63145, 63406, 63427, 63554, 63661, 64093, 64153, 64409, 64544, 65257, 65626,65739 , 66392, 66720, 69177, 69336, 69636, 69823, 69928, 70547, 70633, 71805, 72181, 72200, 72474, 72567, 72973, 73468, 73889, 75730, 75970, 76114, 76342, 76449, 76465, 76791, 78042, 80758, 80778, 81356, 81576, 81689, 81759, 81950, 82562, 83591, 83700, 83821, 83842, 83923, 83929, 84021, 84175, 84417, 84747, 85746, 86129, 86335, 87315, 87648, 87764, 87770, 88221, 90474, 91148, 91150, 91160, 91733, 91772, 91785, 93140, 93148, 96080, 96157, 96313, 96759, 97026, 97320, 97732, 98713, 99707, 99959, 100009, 100020, 100065, 100086, 101270, 101276, 101371, 101376, 101439, 101820, 102392, 102602, 102604, 102896, 189104, 189134 and 189205. Polymorphic variants at the following positions in SEQ ID NO: 6 in particular were associated with an increased risk of osteoarthritis: 5640, 33150, 38247, 38529, 46846, 49723, 50050, 63427, 73889, 189104 and rs428901, where specific embodiments are directed to positions 46846, 73889, 189104 and/or rs428901. In particular, the following polymorphic variants in SEQ ID NO: 6 were associated with risk of osteoarthritis: a cytosine at position 5640, a cytosine at position 33150, an adenine at position 38247, a thymine at position 38529, an adenine at position 46846, a cytosine at position 49723, a cytosine at position 50050, a cytosine a position 63427, a guanine at position 73889, a thymine at position 189104, and an adenine at position rs428901. [0030] Polymorphic variants in and around the BVES locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 7 selected from the group consisting of 241, 801, 899, 2091, 2290, 2440, 4959, 7914, 7969, 7972, 10831, 12399, 13841, 14461, 14680, 16808, 18231, 18394, 18505, 18684, 19257, 20263, 20656, 21499, 21563, 21612, 21834, 22406, 22408, 22685, 23303, 23306, 25139, 25211, 25364, 25381, 25414, 25835, 26214, 27224, 27526, 27934, 28550, 29015, 29879, 29979, 30030, 30585, 31753, 31934, 33227, 33228, 35172, 36901, 36921, 36932, 37061, 37570, 38745, 38970, 39725, 40070, 40460, 41470, 41562, 41956, 42047, 42280, 42358, 42629, 43075, 43387, 43393, 43438, 44115, 44537, 45642, 46629,47496, 47515, 8329, 48862, 48908, 49038, 49080, 50204, 50404, 50426, 50531, 50840, 50964, 50971,51378, 52610, 53906, 53951, 54111, 54149, 55563, 55999, 58415, 58961, 60447, 61377, 61528, 61606, 62140, 62461, 63826, 64950, 65076, 66121, 66406, 67051, 68860, 69014, 70796, 72325, 73414, 75258, 76347, 76839, 77358, 77822, 77946, 80002, 80024, 80285, 80397, 82075, 82153, 83981, 84184, 85089, 85288, 85330, 85581, 85642, 86433, 86904, 88391, 89042, 90828, 92676, 92881, 94227, 94585, 94616, 94712, 94738, 95253, 95522, 95869 and 97856. Polymorphic variants at the following positions in SEQ ID NO: 7 in particular were associated with an increased risk of osteoarthritis: 25414, 25835, 38970, 41470, 44115, 47496, 49038, 50204, 50840, 50964, 50971, 53906, 54149, 58415, 70796, 72325, 75258, 77822, 80002, 85288, 85581, 86904, 90828, 94616, 94712, 95869 and 97856. In particular, the following polymorphic variants in SEQ ED NO: 7 were associated with risk of osteoarthritis: an adenine at position 25414, a cytosine at position 25835, an adenine at position 38970, an adenine at position 41470, an adenine at position 44115, a guanine at position 47496, a cytosine at position 49038, an adenine at position 50204, a thymine at position 50840, a cytosine at position 50964, a cytosine at position 50971, an adenine at position 53906, a guanine at position 54149, a. guanine at position 58415, a thymine at position 70796, a guanine at position 72325, a cytosine at position 75258, an adenine at position 77822, an adenine at position 80002, an adenine at position 85288, an adenine at position 85581, a guanine at position 86904, a guanine at position 90828, an adenine thymine adenine adenine sequence at position 94616, a cytosine at position 94712, a guanine at position 95869 and a cytosine at position 97856. [0031] Polymorphic variants in and around the TM7SF3 locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 8 selected from the group consisting of 230, 231, 5330, 6334, 11372, 11456, 11501, 13393, 16666, 17596, 19710, 19800, 20297, 20967, 32514, 33159, 37600, 41259, 41329, 50060, 53292, 53393, 56417, 56435, 58847, 59595, 59661, 60355, 60407, 62357, 68230, 68516, 69055, 72603, 73928, 85897 and 91554. Polymorphic variants at the following positions in SEQ ID NO: 8 in particular were associated with an increased risk of osteoarthritis: 56435, 59595, 53292, 33159 and 41329, with specific embodiments directed to positions 56435 and/or 59595. In particular, the following polymorphic variants in SEQ ID NO: 8 were associated with risk of osteoarthritis: a thymine thymine repeat at position 56435, a thymine at position 59595, a cytosine at position 53292, a guanine at position 33159 and a thymine at position 41329. [0032] Polymorphic variants in and around the LOXLl locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 10 selected from the group consisting of 213, 249, 1824, 2057, 23O6, 2869, 3976, 4288, 4290, 4434, 5298, 5467, 8486, 8487, 8831, 9036, 9058, 9131, 9732, 9862, 10191, 10270, 16167, 17620, 17751, 17764, 17787, 19401 , 21021, 21902, 22173, 22416, 22653, 24945, 25011, 28563, 48574, 48710, 48880, 50194, 56343, 56455, 56729, 56759, 56895, 57036, 57702, 62515, 62629, 63501, 63547, 64876, 65073, 67149, 67549, 71660, 71906 and 71911. A polymorphic variant at position 65073 in SEQ ID NO: 10, often a guanine, in particular was associated with an increased risk of osteoarthritis. [0033] Polymorphic variants in and around the CASPR4 locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 11 selected from the group consisting of 205, 866, 4212, 5934, 11486, 16969, 22509, 22796, 28097, 28626, 28853, 28873, 30155, 30827, 31956, 32404, 32944, 35205, 35227, 35781, 41052, 45051, 46039, 47276, 47678, 47716, 51014, 54408, 54596, 56853, 61851, 62016, 62461, 68257, 69793, 73976, 73999, 74053, 75315, 75729, 76466, 77216, 77217, 79239, 80825, 81060, S1097, 81426, 84787, 84896, 85165, 86502, 86753, 86941, 88787 and 95598. Polymorphic variants at tire following positions in SEQ ID NO: 11 in particular were associated with an increased risk of osteoarthritis: 47716 and 69793. In particular, the following polymorphic variants in SEQ ID NO: 11 were associated with risk of osteoarthritis: an adenine at position 47716 and a thymine at position 69793. [0034] Polymorphic variants in and around the APOL3 locus were tested for association with osteoarthritis. These include polymorphic variants at positions in SEQ ID NO: 13 selected from the group consisting of 201, 425, 1095, 2201, 7879, 8395, 8461, 9503, 10304, 10695, 16300, 16444, 17591, 17988, 19116, 19358, 20300, 20669, 20891, 21451, 21978, 22785, 24248, 24770, 24844, 25066, 25096, 25309, 25344, 25529, 25537, 25554, 27963, 28134, 28356, 29648, 29986, 30217, 30267, 30315, 30585, 30724, 30897, 30931, 31080, 31246, 31373, 31463, 31467, 32188, 32288, 32520, 32594, 32657, 32677, 32764, 32784, 32830, 32872, 33121, 33348, 33952, 34184, 34361, 35026, 35192, 35600, 36033, 36289, 38869, 39629, 40530, 41621, 42379, 42802, 42865, 43644, 45051, 45828, 45829, 46257, 47286, 47427, 47963, 48013, 48229, 48282, 48376, 48404, 49900, 52699, 52897, 53414, 53487, 54112, 55492, 59766, 60307, 60701, 60952, 61401, 62379, 62870, 62879, 63499, 64284, 64408, 64760, 65230, 66127, , 6634, 66686, 66694, 67113, 67257, 67403, 67609, 68418, 68610, 69629, 70024, 70848, 71428, 71553, 71633, 71768 ,71769, 73039, 73325, 73412, 73547, 73769, 73806, 74467, 74472, 74473, 74482, 74494, 74592, 74670, 74672, 74714, 74723, 74749, 74861, 74892, 74893, 75176, 75705, 75989, 76027, 77949, 77974, 78167, 78310, 78415, 78575, 78590, 78709, 78875, 79864, 81316, 81320, 81409, 81737, 81843, 82102, 82833, 83461, 83624, 83660, 83701, 83708, 83782, 85707, 85717, 86486, 86833, 87115, 87234, 87479, 87561, 87604, 87674, 87958, 87992, 88019, 88074, 88079, 88115, 88118, 88120, 88135, 88142 ,88143, 88149, 88340, 88344, 88512, 88521, 88650, 88827, 89230, 89236, 90754, 90984, 91110, 92026, 92954, 93375, 93794, 94937, 95068, 96188, 97092 and 98812. Polymorphic variants at the following positions in SEQ ID NO: 13 in particular were associated with an increased risk of osteoarthritis: 20300, 46257, 87958, 89236, 30267, 32657, 36289, 38869, 45051, 54112, 60307, 63499, 20891, 52699, 71768, with specific embodiments directed to position 46257. In particular, the following polymorphic variants in SEQ ID NO: 13 were associated with risk of osteoarthritis: an adenine at position 20300, a thymine at position 46257, an adenine at position 89236, a guanine at position 30267, an adenine at position 32657, a cytosine at position 36289, a guanine at position 38869, a thymine at position 45051, a guanine at position 54112, an adenine at position 60307, a thymine at position 63499, a guanine at position 20891, a guanine at position 52699, and a cytosine at position 71768. [0035] Based in part upon analyses summarized in Figures 1A-1 J, regions with significant association have been identified in regions associated with osteoarthritis. Any polymorphic variants associated with osteoarthritis in a region of significant association can be utilized for embodiments described herein. For example, polymorphic variants in a region spanning positions 21233000 to 21243000 (approximately 10,000 nucleotides in length) in a APOB locus, a region spanning chromosome positions 102456500 to 102471500 (approximately 15,000 nucleotides in length) in a IL1RL2 locus, a region spanning chromosome positions 102570000 to 102583000 (approximately 13,000 nucleotides in length) in a ILIRLI locus, a region spanning chromosome positions 175647734 to 175655734 (approximately 8,000 nucleotides in length) in a WASPIP locus, a region spanning chromosome positions 178746000 to 178751000 (approximately 5,000 nucleotides in length) in a ADAMTS2 locus, a region spanning chromosome positions 105595000 to 105615000 (approximately 20,000 nucleotides in length) in a B VES locus, in a region approximately 14,000 nucleotides in length spanning chromosome positions 27052000 to 27066000 in a TM7SF3 locus, a region spanning chromosome positions 71957600 to 71962600 (approximately 5,000 nucleotides in length) in a LOXLl locus, a region spanning chromosome positions 76221000 to 76226000 (approximately 5,000 nucleotides in length) in a CASPR4 locus, and a region approximately 5000 nucleotides in length and spanning chromosome positions 34828750 and 34833750 in an APOL3 locus, have significant association (chromosome positions are within NCBFs Genome build 34).
Additional Polymorphic Variants Associated with Osteoarthritis [0036] Also provided is a method for identifying polymorphic variants proximal to an incident, founder polymorphic variant associated with osteoarthritis. Thus, featured herein are methods for identifying a polymorphic variation associated with osteoarthritis that is proximal to an incident polymorphic variation associated "with osteoarthritis, which comprises identifying a polymorphic variant proximal to the incident polymorphic variant associated with osteoarthritis, where the incident polymorphic variant is in a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B. The nucleotide sequence often comprises a polynucleotide sequence selected from the group consisting of (a) a polynucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (b) a polynucleotide sequence that encodes a polypeptide having an amino acid sequence encoded by a polynucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; and (c) a polynucleotide sequence that encodes a polypeptide having an amino acid sequence that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B or a polynucleotide sequence 90% or more identical to the polynucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B. The presence or absence of an association of the proximal polymorphic variant with osteoarthritis then is determined using a known association method, such as a method described in the Examples hereafter. In an embodiment, the incident polymorphic variant is a polymorphic variant associated with osteoarthritis described herein. In another embodiment, the proximal polymorphic variant identified sometimes is a publicly disclosed polymorphic variant, which for example, sometimes is published in a publicly available database. In other embodiments, the polymorphic variant identified is not publicly disclosed and is discovered using a known method, including, but not limited to, sequencing a region surrounding the incident polymorphic variant in a group of nucleic samples. Thus, multiple polymorphic variants proximal to an incident polymorphic variant are associated with osteoarthritis using this method. [0037] The proximal polymorphic variant often is identified in a region surrounding the incident polymorphic variant. In certain embodiments, this surrounding region is about 50 kb flanking the first polymorphic variant (e.g. about 50 kb 5' of the first polymorphic variant and about 50 kb 3' of the first polymorphic variant), and the region sometimes is composed of shorter flanking sequences, sxich as flanking sequences of about 40 kb, about 30 kb, about 25 kb, about 20 kb, about 15 kb, about 10 kb, about 7 kb, about 5 kb, or about 2 kb 5' and 3' of the incident polymorphic variant. In other embodiments, the region is composed of longer flanking sequences, such as flanking sequences of about 55 kb, about 60 kb, about 65 kb, about 70 kb, about 75 kb, about 80 kb, about 85 kb, about 9O kb, about 95 kb, or about 100 kb 5' and 3' of the incident polymorphic variant. [0038] In certain embodiments, polymorphic variants associated with osteoarthritis are identified iteratively. For example, a first proximal polymorphic variant is associated with osteoarthritis using the methods described above and then another polymorphic variant proximal to the first proximal polymorphic variant is identified (e.g., publicly disclosed or discovered) and the presence or absence of an association of one or more other polymorphic variants proximal to the first proximal polymorphic variant with osteoarthritis is determined. [0039] The methods described herein are useful for identifying or discovering additional polymorphic variants that may be used to further characterize a gene, region or loci associated with a condition, a disease (e.g., osteoarthritis), or a disorder. For example, allelotyping or genotyping data from the additional polymorphic variants may be used to identify a functional mutation or a region of linkage disequilibrium. In certain embodiments, polymorphic variants identified or discovered within a region comprising the first polymorphic variant associated with osteoarthritis are genotyped using the genetic methods and sample selection techniques described herein, and it can be determined whether those polymorphic variants are in linkage disequilibrium with the first polymorphic variant. The size of the region in linkage disequilibrium with the first polymorphic variant also can be assessed using these genotyping methods. Thus, provided herein are methods for determining whether a polymorphic variant is in linkage disequilibrium with a first polymorphic variant associated with osteoarthritis, and such information can be used in prognosis/diagnosis methods described herein.
Isolated Nucleic Acids [0040] Featured herein are isolated PAJ I2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid variants depicted in SEQ ID NO: 1-13, SEQ ID NO: 14-36 or referenced in Table B, and substantially identical nucleic acids thereof. A nucleic acid variant may be represented on one or both strands in a double-stranded nucleic acid or on one chromosomal complement (heterozygous) or both chromosomal complements (homozygous). [0041] ADAMTS2 exists in two forms, a "long" form comprising a molecule approximately 130 kDa in length (e.g., SEQ ID NO: 21 for cDNA sequence and SEQ ID NO: 44 for amino acid sequence), and a "short" form comprising a molecule approximately 70 kDa in length (e.g., SEQ ID NO: 22 for cDNA sequence and SEQ ID NO: 45 for amino acid sequence). Provided herein are polynucleotide sequences encoding both the short and long forms of ADAMTS2. [0042] As used herein, the term "nucleic acid" includes DNA molecules (e.g., a complementary DNA (cDNA) and genomic DNA (gDNA)) and RNA molecules (e.g., mRNA, rRNA, siRNA and tRNA) and analogs of DNA or RNA, for ex-ample, by use of nucleotide analogs. The nucleic acid molecule can be single-stranded and it is often double-stranded. The term "isolated or purified nucleic acid" refers to nucleic acids that are separated from other nucleic acids present in the natural source of the nucleic acid. For example, with regard to genomic DNA, the term "isolated" includes nucleic acids which are separated from the chromosome with which the genomic DNA is naturally associated. An "isolated" nucleic acid is often free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5' and/or 3' ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 -b, 0.5 kb or 0.1 kb of 5' and/or 3' nucleotide sequences which flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived. Moreover, an "isolated" nucleic acid molecule, such as a cDNA molecule, can be substantially free of other cellular material, or culture medium, when produced by recombinant techniques, or substantially free of chemical precursors or other chemicals when chemically synthesized. As used herein, the term "gene" refers to a nucleotide sequence that encodes a polypeptide. [0043] Also included herein are nucleic acid fragments. These fragments often have a nucleotide sequence identical to a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, a nucleotide sequence substantially identical to a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, or a nucleotide sequence that is complementary to the foregoing. The nucleic acid fragment may be identical, substantially identical or homologous to a nucleotide sequence in an exon or an intron in a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, and may encode a domain or part of a domain of a polypeptide. Sometimes, the fragment will comprises one or more of the polymorphic variations described herein as being associated w th osteoarthritis. The nucleic acid fragment is often 50, 100, or 200 or fewer base pairs in length, and is sometimes about 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500, 2000, 3000, 4000, 5000, 10000, 15000, or 20000 base pairs in length. A nucleic acid fragment that is complementary to a. nucleotide sequence identical or substantially identical to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B and hybridizes to such a nucleotide sequence under stringent conditions is often referred to as a "probe." Nucleic acid fragments often include one or more polymorphic sites, or sometimes have an end that is adjacent to a polymoφhic site as described hereafter. [0044] An example of a nucleic acid fragment is an oligonucleotide. As used herein, the term "oligonucleotide" refers to a nucleic acid comprising about 8 to about 50 covalently linked nucleotides, often comprising from about 8 to about 35 nucleotides, and more often from about 10 to about 25 nucleotides. The backbone and nucleotides within an oligonucleotide may be the same as those of naturally occurring nucleic acids, or analogs or derivatives of naturally occurring nucleic acids, provided that oligonucleotides having such analogs or derivatives retain the ability to hybridize specifically to a nucleic acid comprising a targeted polymorphism. Oligonucleotides described herein may be used as hybridization probes or as components of prognostic or diagnostic assays, for example, as described herein. [0045] Oligonucleotides are typically synthesized using standard methods and equipment, such as the ABI™3900 High Throughput DNA Synthesizer and the EXPEDITE™ 8909 Nucleic Acid Synthesizer, both of which are available from Applied Biosystems (Foster City, CA). Analogs and derivatives are exemplified in U.S. Pat. Nos. 4,469,863; 5,536,821; 5,541,306; 5,637,683; 5,637,684; 5,700,922; 5,717,083; 5,719,262; 5,739,308; 5,773,601; 5,886,165; 5,929,226; 5,977,296; 6,140,482; WO 00/56746; WO 01/14398, and related publications. Methods for synthesizing oligonucleotides comprising such analogs or derivatives are disclosed, for example, in the patent publications cited above and in U.S. Pat. Nos. 5,614,622; 5,739,314; 5,955,599; 5,962,674; 6,1 17,992; in WO 00/75372; and in related publications. [0046] Oligonucleotides may also be linked to a second moiety. The second moiety may be an additional nucleotide sequence such as a tail sequence (e.g., a polyadenosine tail), an adapter sequence (e.g., phage Ml 3 universal tail sequence), and others. Alternatively, the second moiety may be a non- nucleotide moiety such as a moiety which facilitates linkage to a solid support or a label to facilitate detection of the oligonucleotide. Such labels include, without limitation, a radioactive label, a fluorescent label, a chemiluminescent label, a paramagnetic label, and the like. The second moiety may be attached to any position of the oligonucleotide, provided the oligonucleotide can hybridize to the nucleic acid comprising the polymorphism.
Uses for Nucleic Acid Sequence [0047] Nucleic acid coding sequences may be used for diagnostic purposes for detection and control of polypeptide expression. Also, included herein are oligonucleotide sequences such as antisense RNA, small-interfering RNA (siRNA) and DNA molecules and ribozymes that function to inhibit translation of a polypeptide. Antisense techniques and RNA interference techniques are known in the art and are described herein. [0048] Ribozymes are enzymatic RNA molecules capable of catalyzing the specific cleavage of RNA. The mechanism of ribozyme action involves sequence specific hybridization of the ribozyme molecule to complementary target RNA, followed by endonucleolytic cleavage. For example, hammerhead motif ribozyme molecules may be engineered that specifically and efficiently catalyze endonucleolytic cleavage of RNA sequences corresponding to or complementary to PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequences or other nucleotide sequences referenced in Table B. Specific ribozyme cleavage sites within any potential RNA target are initially identified by scanning the target molecule for ribozyme cleavage sites which include the following sequences, GUA, GUU and GUC. Once identified, short RNA sequences of between fifteen (15) and twenty (20) ribonucleotides corresponding to the region of the target gene containing the cleavage site may be evaluated for predicte d structural features such as secondary structure that may render the oligonucleotide sequence unsuitable. The suitability of candidate targets may also be evaluated by testing their accessibility to hybridization with complementary oligonucleotides, using ribonuclease protection assays. [0049] Antisense RNA and DNA molecules, siRNA and ribozymes may be prepared by any method known in the art for the synthesis of RNA molecules. These include techniques for chemically synthesizing oligodeoxyribonucleotides well known in the art such as solid phase phosphoramidite chemical synthesis. Alternatively, RNA molecules may be generated by in vitro and in vivo transcription of DNA sequences encoding the antisense RNA molecule. Such DNA sequences may be incorporated into a wide variety of vectors which incorporate suitable RNA polymerase promoters such as the T7 or SP6 polymerase promoters. Alternatively, antisense cDNA constructs that synthesize antisense RNA constitutively or inducibly, depending on the promoter used, can be introduced stably into cell lines. [0050] DNA encoding a polypeptide also may have a number of uses for the diagnosis of diseases, including osteoarthritis, resulting from aberrant expression of a target gene described herein. For example, the nucleic acid sequence may be used in hybridization as. says of biopsies or autopsies to diagnose abnormalities of expression or function (e.g., Southern or 'Northern blot analysis, in situ hybridization assays). [0051] In addition, the expression of a polypeptide during embryonic development may also be determined using nucleic acid encoding the polypeptide. As addressed, infra, production of functionally impaired polypeptide is the cause of various disease states, such as osteoarthritis. In situ hybridizations using polypeptide as a probe may be employed to predict problems related to osteoarthritis. Further, as indicated, infra, administration of human active polypeptide, recom-binantly produced as described herein, may be used to treat disease states related to functionally impaired polypeptide. Alternatively, gene therapy approaches may be employed to remedy deficiencies of functional polypeptide or to replace or compete with dysfunctional polypeptide.
Expression Vectors. Host Cells, and Genetically Engineered Cells [0052] Provided herein are nucleic acid vectors, often expression vectors, which contain a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a sxxbstantially identical sequence thereof. As used herein, the term "vector" refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked and can include a p lasmid, cosmid, or viral vector. The vector can be capable of autonomous replication or it can integrate into a host DNA. Viral vectors may include replication defective retroviruses, adenoviruses and adeno-associated viruses for example. [0053] A vector can include a PADI2, APOB, IL1RL2, ILIRLI , WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B in a form suitable for expression of an encoded target polypeptide or target nucleic acid in a host cell. A "target polypeptide" is a polypeptide encoded by aPA2 I2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a substantially identical nucleotide sequence thereof. The recombinant expression vector typically includes one or more regulatory sequences operatively linked to the nucleic acid sequence to be expressed. The term "regulatory sequence" includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Regulatory sequences include those that direct constitutive expression of a nucleotide sequence, as well as tissue-specific regulatory and/or inducible sequences. The design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of polypeptide desired, and the like. Expression vectors can be introduced into host cells to produce target polypeptides, including fusion polypeptides. [0054] Recombinant expression vectors can be designed for expression of target polypeptides in prokaryotic or eukaryotic cells. For example, target polypeptides can be expressed in E. coli, insect cells (e.g., using baculovirus expression vectors), yeast cells, or mammalian cells. Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase. [0055] Expression of polypeptides in prokaryotes is most often carried out in E. coli with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion polypeptides. Fusion vectors add a number of amino acids to a polypeptide encoded therein, usually to the amino terminus of the recombinant polypeptide. Such fusion vectors typically serve three puφoses: 1) to increase expression of recombinant polypeptide; 2) to increase the solubility of the recombinant polypeptide; and 3) to aid in the purification of the recombinant polypeptide by acting as a ligand in affinity purification. Often, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant polypeptide to enable separation of the recombinant polypeptide from the fusion moiety subsequent to purification of the fusion polypeptide. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith & Johnson, Gene 67: 31-40 (1988)), pMAL (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) which fuse glutathione S- transferase (GST), maltose E binding polypeptide, or polypeptide A, respectively, to the target recombinant polypeptide. [0056] Purified fusion polypeptides can be used in screening assays and to generate antibodies specific for target polypeptides. In a therapeutic embodiment, fusion polypeptide expressed in a refroviral expression vector is used to infect bone marrow cells that are subsequently transplanted into irradiated recipients. The pathology of the subject recipient is then examined after sufficient time has passed (e.g., six (6) weeks). [0057] Expressing the polypeptide in host bacteria with an impaired capacity to proteolytically cleave the recombinant polypeptide is often used to maximize recombinant polypeptide expression (Gottesman, S., Gene Expression Technology: Methods in Enzymology, Academic Presrs, San Diego, California 185: 119-128 (1990)). Another strategy is to alter the nucleotide sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in E. coli (Wada et al, Nucleic Acids Res. 20: 2111-2118 (1992)). Such alteration of nucleotide sequences can be carried out by standard DNA synthesis techniques. [0058] When used in mammalian cells, the expression vector's control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. Recombinant mammalian expression vectors are often capable of directing expression of the nucleic acid in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Non-limiting examples of suitable tissue- specific promoters include an albumin promoter (liver-specific; Pinkert et al, Genes De^v. 1: 268-277 (1987)), lymphoid-specific promoters (Calame & Eaton, Adv. Immunol 43: 235-275 (1 -988)), promoters of T cell receptors (Winoto & Baltimore, EMBOJ. 8: 729-733 (1989)) promoters of immunoglobulins (Banerji et al, Cell 33: 129-140 (1983); Queen & Baltimore, Cell 33s 741-748 (1983)), neuron-specific promoters (e.g., the neurofilament promoter; Byrne & Ruddle, Proc. Natl. Acad. Sci. USA 86: 5473-5477 (1989)), pancreas-specific promoters (Edlund et al, Science 230: 912- 916 (1985)), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Patent No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are sometimes utilized, for example, the murine hox promoters (Kessel & Gruss, Science 249: 374-379 (1990)) and the α-fetopolypeptide promoter (Campes & Tilghman, Genes Dev. 3: 537-546 (1989)). [0059] A PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, Z OXL1, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B also may be cloned into an expression vector in an antisense orientation. Regulatory sequences (e.g., viral promoters and/or enhancers) operatively linked to & PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B cloned in the antisense orientation can be chosen for directing constitutive, tissue specific or cell trype specific expression of antisense RNA in a variety of cell types. Antisense expression vectors can be in the form of a recombinant plasmid, phagemid or attenuated virus. For a discussion of the regulation of gene expression using antisense genes see, e.g., Weintraub et al, Antisense RNA as a molecular tool for genetic analysis, Reviews - Trends in Genetics, Vol. 1(1) (1986). [0060] Also provided herein are host cells that include a PADI2, APOB, IL1RL2, IIL1RL1, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B within a recombinant expression vector or a fragment of such a nucleotide sequence which facilitate homologous recombination into a specific site of the host cell genome. The terms "host cell" and "recombinant host cell" are used interchangeably herein. Such terms refer not only to the particular subject cell but rather also to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein. A host cell can be any prokaryotic or eukaryotic cell. For example, a target polypeptide can be expressed in bacterial cells such as E. coli, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art. [0061] Vectors can be introduced into host cells via conventional transformation or transfection techniques. As used herein, the terms "transformation" and "transfection" are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, transduction/infection, DEAE- dextran-mediated transfection, lipofection, or electroporation. [0062] A host cell provided herein can be used to produce (i.e., express) a target polypeptide or a substantially identical polypeptide thereof. Accordingly, further provided are methods for producing a target polypeptide using host cells described herein. In one embodiment, the method includes culturing host cells into which a recombinant expression vector encoding a target polypeptide has been introduced in a suitable medium such that a target polypeptide is produced. In another embodiment, the metiiod further includes isolating a target polypeptide from the medium or the host cell. [0063] Also provided are cells or purified preparations of cells which include a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 transgene, or other transgene in Table B, or which otherwise misexpress target polypeptide. Cell preparations can consist of human or non-human cells, e.g., rodent cells, e.g., mouse or rat cells, rabbit cells, or pig cells. In preferred embodiments, the cell or cells include a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 transgene or other transgene referenced in Table B (e.g., a heterologous form of & PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 gene or other gene referenced in Table B, such as a human gene expressed in non-human cells). The transgene can be misexpressed, e.g., overexpressed or underexpressed. In other preferred embodiments, the cell or cells include a gene which misexpress an endogenous target polypeptide (e.g., expression of a gene is disrupted, also known as a knockouf . Such cells can serve as a model for studying disorders which are related to mutated or mis-expressed alleles or for use in drug screening. Also provided are human cells (e.g., a hematopoietic stem cells) transfected with a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXL l, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B. [0064] Also provided are cells or a purified preparation thereof (e.g. , human cells) in which an endogenous PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B is under the control of a regulatory sequence that does not normally control the expression of the endogenous gene. The expression characteristics of an endogenous gene within a cell (e.g., a cell line or microorganism) can be modified by inserting a heterologous DNA regulatory element into the genome of the cell such that the inserted regulatory element is operably linked to the corresponding endogenous gene. For example, an endogenous corresponding gene (e.g., a gene which is "transcriptionally silent," not normally expressed, or expressed only at very low levels) may be activated by inserting a regulatory element which is capable of promoting the expression of a normally expressed gene product in that cell. Techniques such as targeted homologous recombinations, can be used to insert the heterologous DNA as described in, e.g., Chappel, US 5,272,071; WO 91/06667, published on May 16, 1991. Transgenic Animals [0065] Non-human transgenic animals that express a heterologous target polypeptide (e.g., expressed from a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B, or substantially identical sequence thereof) can be generated. Such animals are useful for studying the function and/or activity of a target polypeptide and for identifying and/or evaluating modulators of the activity of PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acids, other nucleic acids referenced in Table B, and encoded polypeptides. As used herein, a "transgenic animal" is a non-human animal such as a mammal (e.g., a non-human primate such as chimpanzee, baboon, or macaque; an ungulate such as an equine, bovine, or caprine; or a rodent such as a rat, a mouse, or an Israeli sand rat), a bird (e.g., a chicken or a turkey), an amphibian (e.g., a frog, salamander, or newt), or an insect (e.g., Drosophilα melαnogαster), in which one or more of the cells of the animal includes a transgene. A transgene is exogenous DNA or a rearrangement (e.g., a deletion of endogenous chromosomal DNA) that is often integrated into or occurs in the genome of cells in a transgenic animal. A transgene can direct expression of an encoded gene product in one or more cell types or tissues of the transgenic animal, and other transgenes can reduce expression (e.g., a knockout). Thus, a transgenic animal can be one in which an endogenous nucleic acid homologous to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal (e.g., an embryonic cell of the animal) prior to development of the animal. [0066] Intronic sequences and polyadenylation signals can also be included in the transgene to increase expression efficiency of the transgene. One or more tissue-specific regulatory sequences can be operably linked to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B to direct expression of an encoded polypeptide to particular cells. A transgenic founder animal can be identified based upon the presence of a PADU, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B in its genome and/or expression of encoded mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B can further be bred to other transgenic animals carrying other transgenes. [0067] Target polypeptides can be expressed in transgenic animals or plants by introducing, for example, a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B into the genome of an animal that encodes the target polypeptide. In preferred embodiments the nucleic acid is placed under the control of a tissue specific promoter, e.g., a milk or egg specific promoter, and recovered from the milk or eggs produced by the animal. Also included is a population of cells from a transgenic animal.
Target Polypeptides [0068] Also featured herein are isolated target polypeptides, which are encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or a nucleotide sequence referenced in Table B (e.g., SEQ ID NO: 14-36 or a sequence referenced in Table B), or a substantially identical nucleotide sequence thereof. Examples of PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 polypeptides are set forth in SEQ ID NO: 37-55. The term "polypeptide" as used herein includes proteins and peptides. An "isolated" or "purified" polypeptide or protein is substantially free of cellular material or other contaminating proteins from the cell or tissue source from which the protein is derived, or substantially free from chemical precursors or other chemicals when chemically synthesized. In one embodiment, the language "substantially free" means preparation of a target polypeptide having less than about 30%, 20%, 10% and more preferably 5% (by dry weight), of non-target polypeptide (also referred to herein as a "contaminating protein"), or of chemical precursors or non-target chemicals. When the target polypeptide or a biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, specifically, where culture medium represents less than about 20%, sometimes less than about 10%, and often less than about 5% of the volume of the polypeptide preparation. Isolated or purified target polypeptide preparations are sometimes 0.01 milligrams or more or 0.1 milligrams or more, and often 1.0 milligrams or more and 10 milligrams or more in dry weight. In certain embodiments, the APOL3 polypeptide or polypeptide fragment has APOL3 biological activity, for example, apolipoprotein activity. [0069] Further included herein are target polypeptide fragments. The polypeptide fragment may be a domain or part of a domain of a target polypeptide. The polypeptide fragment may have increased, decreased or unexpected biological activity. The polypeptide fragment is often 50 or fewer, 100 or fewer, or 200 or fewer amino acids in length, and is sometimes 300, 400, 500, 600, 700, or 900 or fewer amino acids in length. In certain embodiments, the polypeptide fragment sometimes is amino acids 90-396 of SEQ ID NO: 53; amino acids 19-325 of SEQ ID NO: 54; or amino acids 1-196 of SEQ ID NO: 55. Shown in Table A below are examples of polypeptide fragments, where approximate amino acid positions are shown in parenthesis (e.g., a Pellino domain starts at about amino acid 3 and ends at about amino acid 412). Amino acid sequences can be accessed using information in Table B and in SEQ ID NO: 37-55. TABLE A
Figure imgf000022_0001
Figure imgf000023_0001
[0070] Interleukin 1 receptor-like 1 isoform 1 (SEQ ID NO: 40) is a member of the interleukin 1 receptor family with no known ligand (orphan receptor). ILIRLI exists in soluble (SEQ ID NO: 41-42) and transmembrane forms, suggesting that it may have ligand or ligand scavenging activity. In an embodiment, ILIRLI protein agents may be administered to treat or prevent the occurrence of OA. ILIRLI protein agents include ILIRLI polypeptides or fragments thereof that have ILIRLI ligand activity (e.g., recombinant polypeptides of SEQ ID NO: 41-42). In a related embodiment, ILIRLI protein agents include ILIRLI polypeptides or fragments thereof that have ILIRLI ligand scavenging activity (e.g., recombinant polypeptide of SEQ ID NO: 40). Isolated ILIRLI polypeptides featured herein include the full-length polypeptide, the mature polypeptide (i.e., the polypeptide without the signal sequence MGFWILAILTILMYSTAA) or a polypeptide fragment containing a domain or part of a ILIRLI domain. The polypeptide fragment may have increased, decreased or unexpected biological activity. [0071] In another embodiment, provided herein are ADAMTS2 polypeptides having an ADAMTS2 activity (e.g., a zinc binding activity, a metalloprotease activity, a procollagen II processing or synthesis activity, or a collagen II synthesis activity in vitro or in vivo). In certain embodiments, the polypeptides are ADAMTS2 proteins including at least one propeptide domain, at least one metalloproteinase domain, at least one disintegrin-like domain, at least one, two, three, and often four thrombospondin domains, and sometimes having a ADAMTS2 activity, e.g., aADAMTS2 activity as described herein. ADAMTS2 polypeptides and fragments thereof often have biological activity, such as excising the N-propeptide of type II procollagens. Methods for monitoring and quantifying this biological activity are known (e.g., Colige et al., J. Biol. Chem. 270: 16724-16730 (1995)). [0072] Human ADAMTS2 protein (SEQ ID NO: 44-45) includes a signal sequence of about 29 amino acids (from amino acid 1 to about amino acid 29 of SEQ ID NO: 44-45). The ADAMTS2 protein without the signal sequence can be approximately 1182 amino acid residues in length (from about amino acid 30 to amino acid 1211 of SEQ ID NO: 44) or approximately 485 amino acid residues in length (from about amino acid 30 to amino acid 514 of SEQ ID NO: 45). Human ADAMTS2 protein includes a "pro" region homologous to the reprolysin family propeptide, which is typically post- translationally cleaved upon conversion of the inactive (or pro-domain containing) protein to the catalytically active metalloprotease. The prodomain region of human ADAMTS2 protein corresponds to about amino acids 30 to 251, 30 to 252, 30 to 253, 30 to 254, 30 to 255, 30 to 256, 30 to 257, 30 to 258 or 30 to 259 of SEQ ID NO: 44-45, where it is understood that the active form of ADAMTS2 does not contain the propeptide domain. [0073] Upon cleavage, catalytically active mature protein can be approximately 960, 959, 958, 957, 956, 955, 954, 953 or 952 amino acids in length (from about amino acid 252, 253, 254, 255, 256, 257, 258, 259 or 260 to amino acid 1211 of SEQ ID NO: 44) or approximately 261, 260, 259, 258, 257,
256, 255, 254 or 253 amino acid residues in length (from about amino acid 252, 253, 254, 255, 256,
257, 258, 259 or 260 to amino acid 514 of SEQ ID NO: 45). [0074] Human ADAMTS2 contains the following regions or other structural features: a signal sequence at about amino acids 1-29 of SEQ ID NO: 44-45; a reprolysin family propeptide domain located at about amino acid residues 30 to 251, 30 to 252, 30 to 253, 30 to 254, 30 to 255, 30 to 256, 30 to 257, 30 to 258 or 30 to 259 of SEQ ID NO: 44-45; a zinc-metalloprotease catalytic domain at about amino acids 251 to 479, 252 to 479, 253 to 479, 254 to 479, 255 to 479, 256 to 479, 257 to 479, 258 to 479 or 259 to 479 of SEQ ID NO: 44-45; a disintegrin domain at about amino acids 480 to 560 of SEQ ID NO: 44; a cysteine-rich domain at about amino acids 618 to 722 of SEQ ID NO: 44; four thrombospondin motifs-2 motifs at about amino acids 561 to 616, 854 to 912, 914 to 971, and 975 to 1029 of SEQ ID NO: 44; and eight N-glycosylation sites located at about amino acids 112, 251, 949, 993, 1031, 1098, 1145, and 1150 of SEQ ID NO: 44. [0075] In other embodiments, provided are methods of increasing the synthesis of procollagen II comprising providing or administering to individuals in need of increasing levels of type II collagen the pharmaceutical or physiologically acceptable composition comprising active human ADAMTS2 protein or fragment thereof, where ADAMTS2 polypeptide fragments having activity are selected from amino acids 252-1211, 253-1211, 254-1211, 255-1211, 256-1211, 257-1211, 258-1211, 259-1211 or 260-1211 of SEQ ID NO: 4, where it is understood that the active form of ADAMTS2 does not contain the propeptide domain. [0076] Substantially identical target polypeptides may depart from the amino acid sequences of target polypeptides in different manners. For example, conservative amino acid modifications may be introduced at one or more positions in the amino acid sequences of target polypeptides. A "conservative amino acid substitution" is one in which the amino acid is replaced by another amino acid having a similar structure and/or chemical function. Families of amino acid residues having similar structures and functions are well known. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Also, essential and non-essential amino acids may be replaced. A "non- essential" amino acid is one that can be altered without abolishing or substantially altering the biological function of a target polypeptide, whereas altering an "essential" amino acid abolishes or substantially alters the biological function of a target polypeptide. Amino acids that are conserved among target polypeptides are typically essential amino acids. In certain embodiments, the polypeptide includes one or more non-synonymous polymorphic variants associated with osteoarthritis, as described above (e.g., a threonine encoded by rsl367117 in an APOB polypeptide). [0077] Also, target polypeptides may exist as chimeric or fusion polypeptides. As used herein, a target "chimeric polypeptide" or target "fusion polypeptide" includes a target polypeptide linked to a non-target polypeptide. A "non-target polypeptide" refers to a polypeptide having an amino acid sequence corresponding to a polypeptide which is not substantially identical to the target polypeptide, which includes, for example, a polypeptide that is different from the target polypeptide and derived from the same or a different organism. The target polypeptide in the fusion polypeptide can correspond to an entire or nearly entire target polypeptide or a fragment thereof. The non-target polypeptide can be fused to the N-terminus or C-terminus of the target polypeptide. [0078] Fusion polypeptides can include a moiety having high affinity for a ligand. For example, the fusion polypeptide can be a GST-target fusion polypeptide in which the target sequences are fused to the C-terminus of the GST sequences, or a polyhistidine-target fusion polypeptide in which the target polypeptide is fused at the N- or C-terminus to a string of histidine residues. Such fusion polypeptides can facilitate purification of recombinant target polypeptide. Expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide), and a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B, or a substantially identical nucleotide sequence thereof, can be cloned into an expression vector such that the fusion moiety is linked in-frame to the target polypeptide. Further, the fusion polypeptide can be a target polypeptide containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression, secretion, cellular internalization, and cellular localization of a target polypeptide can be increased through use of a heterologous signal sequence. Fusion polypeptides can also include all or a part of a serum polypeptide (e.g., an IgG constant region or human serum albumin). [0079] Target polypeptides can be incorporated into pharmaceutical compositions and administered to a subject in vivo. Administration of these target polypeptides can be used to affect the bioavailability of a substrate of the target polypeptide and may effectively increase target polypeptide biological activity in a cell. Target fusion polypeptides may be useful therapeutically for the treatment of disorders caused by, for example, (i) aberrant modification or mutation of a gene encoding a target polypeptide; (ii) mis-regulation of the gene encoding the target polypeptide; and (iii) aberrant post- translational modification of a target polypeptide. Also, target polypeptides can be used as immunogens to produce anti-target antibodies in a subject, to purify target polypeptide ligands or binding partners, and in screening assays to identify molecules which inhibit or enhance the interaction of a target polypeptide with a substrate. [OO80] In addition, polypeptides can be chemically synthesized using techniques known in the art (See, e.g., Creighton, 1983 Proteins. New York, N.Y.: W. H. Freeman and Company; and Hunkapiller et al., (1984) Nature July 12 -18;310(5973):105-11). For example, a relative short fragment can be synthesized by use of a peptide synthesizer. Furthermore, if desired, non-classical amino acids or chemical amino acid analogs can be introduced as a substitution or addition into the fragment sequence. Non-classical amino acids include, but are not limited to, to the D-isomers of the common amino acids, 2,4-diaminobutyric acid, a-amino isobutyric acid, 4-aminobutyric acid, Abu, 2-amino butyric acid, g- Abu, e-Ahx, 6-amino hexanoic acid, Aib, 2-amino isobutyric acid, 3-amino propionic acid, ornithine, norleucine, norvaline, hydroxyproline, sarcosine, citrulline, homocitrulline, cysteic acid, t-butylglycine, t-butylalanine, phenylglycine, cyclohexylalanine, b-alanine, fluoroamino acids, designer amino acids such as b-methyl amino acids, Ca-methyl amino acids, Na-methyl amino acids, and amino acid analogs in general. Furthermore, the amino acid can be D (dextrorotary) or L (levorotary). [0081] Polypeptides and polypeptide fragments sometimes are differentially modified during or after translation, e.g., by glycosylation, acetylation, phosphorylation, amidation, derivatization by known protecting/blocking groups, proteolytic cleavage, linkage to an antibody molecule or other cellular ligand, etc. Any of numerous chemical modifications may be carried out by known techniques, including but not limited, to specific chemical cleavage by cyanogen bromide, trypsin, chymotrypsin, papain, V8 protease, NaBH4; acetylation, formylation, oxidation, reduction; metabolic synthesis in the presence of tunicamycin; and the like. Additional post-translational modifications include, for example, N-linked or O-linked carbohydrate chains, processing of N-terminal or C-terminal ends), attachment of chemical moieties to the amino acid backbone, chemical modifications of N-linked or O-linked carbohydrate chains, and addition or deletion of an N-terminal methionine residue as a result of prokaryotic host cell expression. The polypeptide fragments may also be modified with a detectable label, such as an enzymatic, fluorescent, isotopic or affinity label to allow for detection and isolation of the polypeptide. [0082] Also provided are chemically modified derivatives of polypeptides that can provide additional advantages such as increased solubility, stability and circulating time of the polypeptide, or decreased immunogenicity (see e.g., U.S. Pat. No: 4,179,337. The chemical moieties for derivitization may be selected from water soluble polymers such as polyethylene glycol, ethylene glycol/propylene glycol copolymers, carboxymethylcellulose, dextran, polyvinyl alcohol and the like. The polypeptides may be modified at random positions within the molecule, or at predetermined positions within the molecule and may include one, two, three or more attached chemical moieties. [0083] The polymer may be of any molecular weight, and may be branched or unbranched. For polyethylene glycol, the preferred molecular weight is between about 1 kDa and about 100 kDa (the term "about" indicating that in preparations of polyethylene glycol, some molecules will weigh more, some less, than the stated molecular weight) for ease in handling and manufacturing. Other sizes may be used, depending on the desired therapeutic profile (e.g., the duration of sustained release desired, the effects, if any on biological activity, the ease in handling, the degree or lack of antigenicity and other known effects of the polyethylene glycol to a therapeutic protein or analog). [0084] The polymers should be attached to the polypeptide with consideration of effects on functional or antigenic domains of the polypeptide. There are a number of attachment methods available to those skilled in the art (e.g., EP 0 401 384 (coupling PEG to G-CSF) and Malik et al. (1992) Exp Hematol. September;20(8): 1028-35 (pegylation of GM-CSF using tresyl chloride)). For example, polyethylene glycol may be covalently bound through amino acid residues via a reactive group, such as a free amino or carboxyl group. Reactive groups are those to which an activated polyethylene glycol molecule may be bound. The amino acid residues having a free amino group may include lysine residues and the N-terminal amino acid residues; those having a free carboxyl group may include aspartic acid residues, glutamic acid residues and the C-terminal amino acid residue. Sulfhydryl groups may also be used as a reactive group for attaching the polyethylene glycol molecules. For therapeutic purposes, the attachment sometimes is at an amino group, such as attachment at the N-terminus or lysine group. [0085] Proteins can be chemically modified at the N-terminus. Using polyethylene glycol as an illustration of such a composition, one may select from a variety of polyethylene glycol molecules (by molecular weight, branching, and the like), the proportion of polyethylene glycol molecules to protein (polypeptide) molecules in the reaction mix, the type of pegylation reaction to be performed, and the method of obtaining the selected N-terminally pegylated protein. The method of obtaining the N- terminally pegylated preparation (i.e., separating this moiety from other monopegylated moieties if necessary) may be by purification of the N-terminally pegylated material from a population of pegylated protein molecules. Selective proteins chemically modified at the N-terminus may be accomplished by reductive alkylation, which exploits differential reactivity of different types of primary amino groups (lysine versus the N-terminal) available for derivatization in a particular protein. Under the appropriate reaction conditions, substantially selective derivatization of the protein at the N-terminus with a carbonyl group containing polymer is achieved.
Substantially Identical Nucleic Acids and Polypeptides [0086] Nucleotide sequences and polypeptide sequences that are substantially identical to a PADI2, APOB, IL1R 2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B and the target polypeptide sequences encoded by those nucleotide sequences, respectively, are included herein. The term "substantially identical" as used herein refers to two or more nucleic acids or polypeptides sharing one or more identical nucleotide sequences or polypeptide sequences, respectively. Included are nucleotide sequences or polypeptide sequences that are 55% or more, 60%> or more, 65% or more, 70% or more, 75%> or more, 80% or more, 85% or more, 90% or more, 95% or more (each often within a 1%, 2%, 3%> or 4% variability) identical to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, or other nucleotide sequence referenced in Table B, or the encoded target polypeptide amino acid sequences. One test for determining whether two nucleic acids are substantially identical is to determine the percent of identical nucleotide sequences or polypeptide sequences shared between the nucleic acids or polypeptides. [0087] Calculations of sequence identity are often performed as follows. Sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison puφoses). The length of a reference sequence aligned for comparison purposes is sometimes 30% or more, 40% or more, 50%> or more, often 60%) or more, and more often 70% or more, 80% or more, 90% or more, or 100% of the length of the reference sequence. The nucleotides or amino acids at corresponding nucleotide or polypeptide positions, respectively, are then compared among the two sequences. When a position in the first sequence is occupied by the same nucleotide or amino acid as the corresponding position in the second sequence, the nucleotides or amino acids are deemed to be identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, introduced for optimal alignment of the two sequences. [0088] Comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. Percent identity between two amino acid or nucleotide sequences can be determined using the algorithm of Meyers & Miller, CABIOS 4: 11-17 (1989), which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4. Also, percent identity between two amino acid sequences can be determined using the Needleman & Wunsch, J. Mol. Biol. 48: 444-453 (1970) algorithm which has been incorporated into the GAP program in the GCG software package (available at the http address www.gcg.com), using either a Blossum 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. Percent identity between two nucleotide sequences can be determined using the GAP program in the GCG software package (available at http address www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. A set of parameters often used is a Blossum 62 scoring matrix with a gap open penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5. [0089] Another manner for determining if two nucleic acids are substantially identical is to assess whether a polynucleotide homologous to one nucleic acid will hybridize to the other nucleic acid under stringent conditions. As use herein, the term "stringent conditions" refers to conditions for hybridization and washing. Stringent conditions are known to those skilled in the art and can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. , 6.3.1-6.3.6 (1989). Aqueous and non-aqueous methods are described in that reference and either can be used. An example of stringent hybridization conditions is hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 50°C. Another example of stringent hybridization conditions are hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 55°C. A further example of stringent hybridization conditions is hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 60°C. Often, stringent hybridization conditions are hybridization in 6X sodium chloride/sodium citrate (SSC) at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 65°C. More often, stringency conditions are 0.5M sodium phosphate, 7% SDS at 65°C, followed by one or more washes at 0.2X SSC, 1% SDS at 65°C. [0090] An example of a substantially identical nucleotide sequence to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B is one that has a different nucleotide sequence but still encodes the same polypeptide sequence encoded by the nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B. Another example is a nucleotide sequence that encodes a polypeptide having a polypeptide sequence that is more than 70% or more identical to, sometimes more than 75% or more, 80%) or more, or 85% or more identical to, and often more than 90% or more and 95%o or more identical to a polypeptide sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B. [0091] Nucleotide sequences in SEQ ID NO: 1-13 or referenced in Table B and amino acid sequences of encoded polypeptides can be used as "query sequences" to perform a search against public databases to identify other family members or related sequences, for example. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul et al, J. Mol. Biol. 215: 403-10 (1990). BLAST nucleotide searches can be performed with the NBLAST program, score = 100, wordlength = 12 to obtain nucleotide sequences homologous to nucleotide sequences in SEQ ID NO: 1-13, SEQ ID NO: 14-36 or referenced in Table B. BLAST polypeptide searches can be performed with the XBLAST program, score = 50, wordlength = 3 to obtain amino acid sequences homologous to polypeptides encoded by the nucleotide sequences of SEQ ID NO: 14-36 or referenced in Table B. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al, Nucleic Acids Res. 25(17): 3389-3402 (1997). When utilizing BLAST and Gapped BLAST programs, default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used (see the http address www.ncbi.nlm.nih.gov). [0092] A nucleic acid that is substantially identical to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B may include polymorphic sites at positions equivalent to those described herein when the sequences are aligned. For example, using the alignment procedures described herein, SNPs in a sequence substantially identical to a sequence in SEQ ID NO: 1-13 or referenced in Table B can be identified at nucleotide positions that match (i.e., align) with nucleotides at SNP positions in each nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B. Also, where a polymorphic variation results in an insertion or deletion, insertion or deletion of a nucleotide sequence from a reference sequence can change the relative positions of other polymorphic sites in the nucleotide sequence. [0093] Substantially identical nucleotide and polypeptide sequences include those that are naturally occurring, such as allelic variants (same locus), splice variants, homologs (different locus), and orthologs (different organism) or can be non-naturally occurring. Non-naturally occurring variants can be generated by mutagenesis techniques, including those applied to polynucleotides, cells, or organisms. The variants can contain nucleotide substitutions, deletions, inversions and insertions. Variation can occur in either or both the coding and non-coding regions. The variations can produce both conservative and non-conservative amino acid substitutions (as compared in the encoded product). Orthologs, homologs, allelic variants, and splice variants can be identified using methods known in the art. These variants normally comprise a nucleotide sequence encoding a polypeptide that is 50% or more, about 55% or more, often about 70-75% or more or about 80-85%) or more, and sometimes about 90-95% or more identical to the amino acid sequences of target polypeptides or a fragment thereof. Such nucleic acid molecules can readily be identified as being able to hybridize under stringent conditions to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B or a fragment of this sequence. Nucleic acid molecules corresponding to orthologs, homologs, and allelic variants of a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B can further be identified by mapping the sequence to the same chromosome or locus as the nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B. [0094] Also, substantially identical nucleotide sequences may include codons that are altered with respect to the naturally occurring sequence for enhancing expression of a target polypeptide in a particular expression system. For example, the nucleic acid can be one in which one or more codons are altered, and often 10% or more or 20% or more of the codons are altered for optimized expression in bacteria (e.g., E. coli.), yeast (e.g., S. cervesiae), human (e.g., 293 cells), insect, or rodent (e.g., hamster) cells.
Methods for Identifying Risk of Osteoarthritis [0095] Methods for prognosing and diagnosing osteoarthritis are included herein. These methods include detecting the presence or absence of one or more polymorphic variations in a nucleotide sequence associated with osteoarthritis, such as variants in or around the loci set forth herein, or a substantially identical sequence thereof, in a sample from a subject, where the presence of a polymorphic variant described herein is indicative of a risk of osteoarthritis. Determining a risk of osteoarthritis sometimes refers to determining whether an individual is at an increased risk of osteoarthritis (e.g., intermediate risk or higher risk). [0096] Thus, featured herein is a method for identifying a subject who is at risk of osteoarthritis, which comprises detecting an aberration associated with osteoarthritis in a nucleic acid sample from the subject. An embodiment is a method for detecting a risk of osteoarthritis in a subject, which comprises detecting the presence or absence of a polymorphic variation associated with osteoarthritis at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject, where the nucleotide sequence comprises a polynucleotide sequence selected from the group consisting of: (a) a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1- 13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, or a nucleotide sequence about 90% or more identical to a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; and (d) a fragment of a nucleotide sequence of (a), (b), or (c) comprising the polymorphic site; whereby the presence of the polymorphic variation is indicative of a predisposition to osteoarthritis in the subject. In certain embodiments, polymorphic variants at the positions described herein are detected for determining a risk of osteoarthritis, and polymorphic variants at positions in linkage disequilibrium with these positions are detected for determining a risk of osteoarthritis. As used herein, the terms "SEQ ID NO: 1-13" and other nucleotide sequences "referenced in Table B" refers to individual sequences in SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13 or any individual sequence referenced in Table B, or any individual nucleic acid sequence provided in the sequence listing, including SEQ ID NO: 14-36 each sequence being separately applicable to embodiments described herein. [0097] Risk of osteoarthritis sometimes is expressed as a probability, such as an odds ratio, percentage, or risk factor. Risk often is based upon the presence or absence of one or more polymorphic variants described herein, and also may be based in part upon phenotypic traits of the individual being tested. Methods for calculating risk based upon patient data are well known (see, e.g., Agresti, Categorical Data Analysis, 2nd Ed. 2002. Wiley). Allelotyping and genotyping analyses may be carried out in populations other than those exemplified herein to enhance the predictive power of the prognostic method. These further analyses are executed in view of the exemplified procedures described herein, and may be based upon the same polymorphic variations or additional polymorphic variations. [0098] In certain embodiments, determining the presence of a combination of two or more polymorphic variants associated with osteoarthritis in one or more genetic loci (e.g., one or more genes) of the sample is determined to identify, quantify and/or estimate, risk of osteoarthritis. The risk often is the probability of having or developing osteoarthritis. The risk sometimes is expressed as a relative risk with respect to a population average risk of osteoarthritis, and sometimes is expressed as a relative risk with respect to the lowest risk group. Such relative risk assessments often are based upon penetrance values determined by statistical methods, and are particularly useful to clinicians and insurance companies for assessing risk of osteoarthritis (e.g., a clinician can target appropriate detection, prevention and therapeutic regimens to a patient after determining the patient's risk of osteoarthritis, and an insurance company can fine tune actuarial tables based upon population genotype assessments of osteoarthritis risk). Risk of osteoarthritis sometimes is expressed as an odds ratio, which is the odds of a particular person having a genotype has or will develop osteoarthritis with respect to another genotype group (e.g., the most disease protective genotype or population average). In related embodiments, the determination is utilized to identify a subject at risk of osteoarthritis. In an embodiment, two or more polymorphic variations are detected in two or more regions in human genomic DNA associated with increased risk of osteoarthritis, such as a locus containing a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 or other locus referenced in Table B, for example. In certain embodiments, 3 or more, or 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 80, 90, 100 or more polymorphic variants are detected in the sample. In specific embodiments, polymorphic variants are detected in a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 region or other region referenced in Table B, for example. In another embodiment, polymorphic variants are detected at two or three positions in a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B. In certain embodiments, polymorphic variants are detected at other genetic loci (e.g., the polymorphic variants can be detected in a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B in addition to other loci or only in other loci), where the other loci include but are not limited to those described in patent applications 60/559,011; 60/559,202; 60/559,203; 60/559,042; 60/559,275; 60/559,040 and 60/559,225, each of which is entitled "Methods for Identifying Risk of Osteoarthritis and Treatments Thereof," each of which was filed on 1 April 2004 and each of which is incorporated herein by reference in its entirety in jurisdictions allowing incorporation by reference. [0099] Results from prognostic tests may be combined with other test results to diagnose osteoarthritis. For example, prognostic results may be gathered, a patient sample may be ordered based on a determined predisposition to osteoarthritis, the patient sample is analyzed, and the results of the analysis may be utilized to diagnose osteoarthritis. Also osteoarthritis diagnostic method can be developed from studies used to generate prognostic methods in which populations are stratified into subpopulations having different progressions of osteoarthritis. In another embodiment, prognostic results may be gathered, a patient's risk factors for developing osteoarthritis (e.g., age, weight, occupational history, race, diet) analyzed, and a patient sample may be ordered based on a determined predisposition to osteoarthritis. [0100] The nucleic acid sample typically is isolated from a biological sample obtained from a subject. For example, nucleic acid can be isolated from blood, saliva, sputum, urine, cell scrapings, and biopsy tissue. The nucleic acid sample can be isolated from a biological sample using standard techniques, such as the technique described in Example 2. As used herein, the term "subject" refers primarily to humans but also refers to other mammals such as dogs, cats, and ungulates (e.g., cattle, sheep, and swine). Subjects also include avians (e.g., chickens and turkeys), reptiles, and fish (e.g., salmon), as embodiments described herein can be adapted to nucleic acid samples isolated from any of these organisms. The nucleic acid sample may be isolated from the subject and then directly utilized in a method for determining the presence of a polymorphic variant, or alternatively, the sample may be isolated and then stored (e.g., frozen) for a period of time before being subjected to analysis. [0101] The presence or absence of a polymorphic variant is determined using one or both chromosomal complements represented in the nucleic acid sample. Determining the presence or absence of a polymorphic variant in both chromosomal complements represented in a nucleic acid sample from a subject having a copy of each chromosome is useful for determining the zygosity of an individual for the polymorphic variant (i.e., whether the individual is homozygous or heterozygous for the polymorphic variant). Any oligonucleotide-based diagnostic may be utilized to determine whether a sample includes the presence or absence of a polymoφhic variant in a sample. For example, primer extension methods, ligase sequence determination methods (e.g., U.S. Pat. Nos. 5,679,524 and 5,952,1 '4, and WO 01/27326), mismatch sequence determination methods (e.g., U.S. Pat. Nos. 5,851,770; 5,958,692; 6,110,684; and 6,183,958), microarray sequence determination methods, restriction fragment length polymorphism (RFLP), single strand conformation polymorphism detection (SSCP) (e.g., U.S. Pat. Nos. 5,891,625 and 6,013,499), PCR-based assays (e.g., TAQMAN® PCR System (Applied Biosystems)), and nucleotide sequencing methods may be used. [0102] Oligonucleotide extension methods typically involve providing a pair of oligonucleotide primers in a polymerase chain reaction (PCR) or in other nucleic acid amplification methods for the purpose of amplifying a region from the nucleic acid sample that comprises the polymorphic variation. One oligonucleotide primer is complementary to a region 3' of the polymorphism and the other is complementary to a region 5' of the polymorphism. A PCR primer pair may be used in methods disclosed in U.S. Pat. Nos. 4,683,195; 4,683,202, 4,965,1 88; 5,656,493; 5,998,143; 6,140,054; WO 01/27327; and WO 01/27329 for example. PCR primer pairs may also be used in any commercially available machines that perform PCR, such as any of the GENEAMP® Systems available from Applied Biosystems. Also, those of ordinaiy skill in the art will be able to design oligonucleotide primers based upon a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B using knowledge available in the art. [0103] Also provided is an extension oligonucleotide that hybridizes to the amplified fragment adjacent to the polymorphic variation. As used herein, the term "adjacent" refers to the 3' end of the extension oligonucleotide being often 1 nucleotide from the 5' end of the polymorphic site, and sometimes 2, 3, 4, 5, 6, 7, 8, 9, or 10 nucleotides from the 5' end of the polymorphic site, in the nucleic acid when the extension oligonucleotide is hybridized to the nucleic acid. The extension oligonucleotide then is extended by one or more nucleotides, and the number and/or type of nucleotides that are added to the extension oligonucleotide determine whether the polymorphic variant is present. Oligonucleotide extension methods are disclosed, for example, in U.S. Pat. Nos. 4,656,127; 4,851,331; 5,679,524; 5,834,189; 5,876,934; 5,908,755; 5,912,118; 5,976,802; 5,981,186; 6,004,744; 6,013,431; 6,017,702; 6,046,005; 6,087,095; 6,210,891; and WO 01/20039. Oligonucleotide extension methods using mass spectrometry are described, for example, in U.S. Pat. Nos. 5,547,835; 5,605,798; 5,691,141; 5,849,542; 5,869,242; 5,928,906; 6,043,031; and 6,194,144, and a method often utilized is described herein in Example 2. [010)4] A microarray can be utilized for determining whether a polymorphic variant is present or absent in a nucleic acid sample. A microarray may include any oligonucleotides described herein, and methods for making and using oligonucleotide microarrays suitable for diagnostic use are disclosed in U.S. Pat. Nos. 5,492,806; 5,525,464; 5,589,330; 5,695,940; 5,849,483; 6,018,041; 6,045,996; 6,136,541; 6,142,681; 6,156,501; 6,197,506; 6,223,127; 6,225,625; 6,229,911; 6,239,273; WO 00/52625; WO 01/25485; and WO 01/29259. The microarray typically comprises a solid support and the oligonucleotides may be linked to this solid support by covalent bonds or by non-covalent interactions. The oligonucleotides may also be linked to the solid support directly or by a spacer molecule. A microarray may comprise one or more oligonucleotides complementary to a polymorphic site set forth herein. [01OS] A kit also may be utilized for determining whether a polymorphic variant is present or absent in a nucleic acid sample. A kit often comprises one or more pairs of oligonucleotide primers useful for amplifying a fragment of a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B or a substantially identical sequence thereof, where the fragment includes a polymorphic site. The kit sometimes comprises a polymerizing agent, for example, a thermostable nucleic acid polymerase such as one disclosed in U.S. Pat. Nos. 4,889,818 or 6,077,664. Also, the kit often comprises an elongation oligonucleotide that hybridizes to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B in a nucleic acid sample adjacent to the polymorphic site. Where the kit includes an elongation oligonucleotide, it also often comprises chain elongating nucleotides, such as dATP, dTTP, dGTP, dCTP, and dITP, including analogs of dATP, dTTP, dGTP, dCTP and dITP, provided that such analogs are substrates for a thermostable nucleic acid polymerase and can be incorporated into a nucleic acid chain elongated from the extension oligonucleotide. Along with chain elongating nucleotides would be one or more chain terminating nucleotides such as ddATP, ddTTP, ddGTP, ddCTP, and the like. In an embodiment, the kit comprises one or more oligonucleotide primer pairs, a polymerizing agent, chain elongating nucleotides, at least one elongation oligonucleotide, and one or more chain terminating nucleotides. Kits optionally include buffers, vials, microtiter plates, and instructions for use. [0106] An individual identified as being at risk of osteoarthritis may be heterozygous or homozygous with respect to the allele associated with a higher risk of osteoarthritis. A subject homozygous for an allele associated with an increased risk of osteoarthritis is at a comparatively high risk of osteoarthritis, a subject heterozygous for an allele associated with an increased risk of osteoarthritis is at a comparatively intermediate risk of osteoarthritis, and a subject homozygous for an allele associated with a decreased risk of osteoarthritis is at a comparatively low risk of osteoarthritis. A genotype may be assessed for a complementary strand, such that the complementary nucleotide at a particular position is detected. [0107] Also featured are methods for determining risk of osteoarthritis and/or identifying a subject at risk of osteoarthritis by contacting a polypeptide or protein encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B from a subject with an antibody that specifically binds to an epitope associated with increased risk of osteoarthritis in the polypeptide (e.g. , an epitope comprising a valine at position 245 in an IR1LR1 polypeptide).
Applications of Prognostic and Diagnostic Results to Pharmaco genomic Methods [0108] Pharmacogenomics is a discipline that involves tailoring a treatment for a subject according to the subject's genotype as a particular treatment regimen may exert a differential effect depending upon the subject's genotype. For example, based upon the outcome of a prognostic test described herein, a clinician or physician may target pertinent information and preventative or therapeutic treatments to a subject who would be benefited by the information or treatment and avoid directing such information and treatments to a subject who would not be benefited (e.g., the treatment has no therapeutic effect and/or the subject experiences adverse side effects). [0109] The following is an example of a pharmacogenomic embodiment. A particular treatment regimen can exert a differential effect depending upon the subject's genotype. Where a candidate therapeutic exTiibits a significant interaction with a major allele and a comparatively weak interaction with a minor allele (e.g., an order of magnitude or greater difference in the interaction), such a therapeutic typically would not be administered to a subject genotyped as being homozygous for the minor allele, and sometimes not administered to a subject genotyped as being heterozygous for the minor allele. In another example, where a candidate therapeutic is not significantly toxic when administered to subjects who are homozygous for a major allele but is comparatively toxic when administered to subjects heterozygous or homozygous for a minor allele, the candidate therapeutic is not typically administered to subjects who are genotyped as being heterozygous or homozygous with respect to the minor allele. [0110] The methods described herein are applicable to pharmacogenomic methods for preventing, alleviating or treating osteoarthritis. For example, a nucleic acid sample from an individual may be subjected to a prognostic test described herein. Where one or more polymorphic variations associated with increased risk of osteoarthritis are identified in a subject, information for preventing or treating osteoarthritis and/or one or more osteoarthritis treatment regimens then may be prescribed to that subject. [0111] In certain embodiments, a treatment or preventative regimen is specifically prescribed and/or administered to individuals who will most benefit from it based upon their risk of developing osteoarthritis assessed by the methods described herein. Thus, provided are methods for identifying a subject predisposed to osteoarthritis and then prescribing a therapeutic or preventative regimen to individuals identified as having a predisposition. Thus, certain embodiments are directed to a method for reducing osteoarthritis in a subject, which comprises: detecting the presence or absence of a polymorphic variant associated with osteoarthritis in a nucleotide sequence in a nucleic acid sample from a subject, where the nucleotide sequence comprises a polynucleotide sequence selected from the group consisting of: (a) a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, or a nucleotide sequence about 90% or more identical to a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; and (d) a fragment of a polynucleotide sequence of (a), (b), or (c); and prescribing or administering a treatment regimen to a subj ect from whom the sample originated where the presence of a polymorphic variation associated with osteoarthritis is detected in the nucleotide sequence. In these methods, predisposition results may be utilized in combination with other test results to diagnose osteoarthritis . [0112] Certain preventative treatments often are prescribed to subjects having a predisposition to ost oarthritis and where the subject is diagnosed with osteoarthritis or is diagnosed as having symptoms indicative of an early stage of osteoarthritis. The treatment sometimes is preventative (e.g., is prescribed or administered to reduce the probability that osteoarthritis arises or progresses), sometimes is therapeutic, and sometimes delays, alleviates or halts the progression of osteoarthritis. Any known preventative or therapeutic treatment for alleviating or preventing the occurrence of osteoarthritis is prescribed and/or administered. For example, the treatment often is directed to decreasing pain and improving joint movement. Examples of OA treatments include exercises to keep joints flexible and improve muscle strength. Different medications to control pain, including corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs, e.g., Voltaren); cyclooxygenase-2 (COX-2) inhibitors (e.g-. , Celebrex, Vioxx, Mobic, and Bextra); monoclonal antibodies (e.g., Remicade); tumor necrosis factor inhibitors (e.g., Enbrel); or injections of glucocorticoids, hyaluronic acid or chondrotin sulfate into joints that are inflamed and not responsive to NSAIDS. Orally administered chondroitin sulfate also may be used as a therapeutic, as it may increase hyaluronic acid levels and viscosity of synovial fluid, and decrease collagenase levels in synovial fluid. Also, glucosamine can serve as an OA therapeutic as delivering it into joints may inhibit enzymes involved in cartilage degradation and enhance the production of hyaluronic acid. For mild pain without inflammation, acetaminophen may be used. Other treatments include: heat/cold therapy for temporary pain relief; joint protection to prevent strain or stress on painful joints; surgery to relieve chronic pain in damaged joints; and weight control to prevent extra stress on weight-bearing joints. [0113] As therapeutic approaches for treating osteoarthritis continue to evolve and improve, the goal of treatments for osteoarthritis related disorders is to intervene even before clinical signs first manifest. Thus, genetic markers associated with susceptibility to osteoarthritis prove useful for early diagnosis, prevention and treatment of osteoarthritis. [0114] As osteoarthritis preventative and treatment information can be specifically targeted to subjects in need thereof (e.g., those at risk of developing osteoarthritis or those in an early stage of osteoarthritis), provided herein is a method for preventing or reducing the risk of developing osteoarthritis in a subject, which comprises: (a) detecting the presence or absence of a polymorphic variation associated with osteoarthritis at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) identifying a subject with a predisposition to osteoarthritis, whereby the presence of the polymorphic variation is indicative of a predisposition to osteoarthritis in the subject; and (c) if such a predisposition is identified, providing the subject with information about methods or products to prevent or reduce osteoarthritis or to delay the onset of osteoarthritis. Also provided is a method of targeting information or advertising to a subpopulation of a human population based on the subpopulation being genetically predisposed to a disease or condition, which comprises: (a) detecting the presence or absence of a polymorphic variation associated with osteoarthritis at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) identifying the subpopulation of subjects in which the polymorphic variation is associated with osteoarthritis; and (c) providing information only to the subpopulation of subjects about a particular product which may be obtained and consumed or applied by the subject to help prevent or delay onset of the disease or condition. [0115] Pharmacogenomics methods also may be used to analyze and predict a response to osteoarthritis treatment or a drug. For example, if pharmacogenomics analysis indicates a likelihood that an individual will respond positively to osteoarthritis treatment with a particular drug, the drug may be administered to the individual. Conversely, if the analysis indicates that an individual is likely to respond negatively to treatment with a particular drug, an alternative course of treatment may be prescribed. A negative response may be defined as either the absence of an efficacious response or the presence of toxic side effects. The response to a therapeutic treatment can be predicted in a background study in which subjects in any of the following populations are genotyped: a population that responds favorably to a treatment regimen, a population that does not respond significantly to a treatment regimen, and a population that responds adversely to a treatment regimen (e.g., exhibits one or more side effects). These populations are provided as examples and other populations and subpopulations may be analyzed. Based upon the results of these analyses, a subject is genotyped to predict whether he or she will respond favorably to a treatment regimen, not respond significantly to a treatment regimen, or respond adversely to a treatment regimen. [0116] The tests described herein also are applicable to clinical drug trials. One or more polymorphic variants indicative of response to an agent for treating osteoarthritis or to side effects to an agent for treating osteoartliritis may be identified using the methods described herein. Thereafter, potential participants in clinical trials of such an agent may be screened to identify those individuals most likely to respond favorably to the drug and exclude those likely to experience side effects. In that way, the effectiveness of drug treatment may be measured in individuals who respond positively to the drug, without lowering the measurement as a result of the inclusion of individuals who are unlikely to respond positively in the study and without risking undesirable safety problems. [0117] Thus, another embodiment is a method of selecting an individual for inclusion in a clinical trial of a treatment or drug comprising the steps of: (a) obtaining a nucleic acid sample from an individual; (b) determining the identity of a polymorphic variation which is associated with a positive response to the treatment or the drug, or at least one polymorphic variation which is associated with a negative response to the treatment or the drug in the nucleic acid sample, and (c) including the individual in the clinical trial if the nucleic acid sample contains said polymorphic variation associated with a positive response to the treatment or the drug or if the nucleic acid sample lacks said polymorphic variation associated with a negative response to the treatment or the drug. In addition, the methods described herein for selecting an individual for inclusion in a clinical trial of a treatment or drug encompass methods with any further limitation described in this disclosure, or those following, specified alone or in any combination. The polymorphic variation may be in a sequence selected individually or in any combination from the group consisting of (i) a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (ii) a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; (iii) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B, or a nucleotide sequence about 90% or more identical to a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B; and (iv) a fragment of a polynucleotide sequence of (i), (ii), or (iii) comprising the polymorphic site. The including step (c) optionally comprises administering the drug or the treatment to the individual if the nucleic acid sample contains the polymorphic variation associated with a positive response to the treatment or the drug and the nucleic acid sample lacks said biallelic marker associated with a negative response to the treatment or the drug. [0118] Also provided herein is a method of partnering between a diagnostic/prognostic testing provider and a provider of a consumable product, which comprises: (a) the diagnostic/prognostic testing provider detects the presence or absence of a polymorphic variation associated with osteoarthritis at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) the diagnostic/prognostic testing provider identifies the subpopulation of subjects in which the polymorphic variation is associated with osteoarthritis; (c) the diagnostic/prognostic testing provider forwards information to the subpopulation of subjects about a particular product which may be obtained and consumed or applied by t ie subject to help prevent or delay onset of the disease or condition; and (d) the provider of a consumable product forwards to the diagnostic test provider a fee every time the diagnostic/prognostic test provider forwards information to the subject as set forth in step (c) above.
Compositions Comprising Osteoarthritis-Directed Molecules [0119] Featured herein is a composition comprising a cell from a subject having osteoarthritis or at risk of osteoarthritis and one or more molecules specifically directed and targeted to a nucleic acid comprising a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, other nucleotide sequence referenced in Table B, or an encoded amino acid sequence referenced herein. Such directed molecules include, but are not limited to, a compound that binds to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, or other nucleotide sequence referenced in Table B, or encoded amino acid sequence; a RNAi or siRNA molecule having a strand complementary or substantially complementary to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B (e.g., hybridizes to a PADI2, APOB, IL1JRL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B under conditions of high stringency); an antisense nucleic acid complementary or substantially complementary to an RNA encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B (e.g., hybridizes to a PADI2, APOB, IL1KL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B under conditions of high stringency); a ribozyme that hybridizes to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B (e.g., -hybridizes to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B under conditions of high stringency); a nucleic acid aptamer that specifically binds a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B; and an antibody that specifically binds to a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B or binds to a nucleic acid having such a nucleotide sequence. In an embodiment, the antibody selectively binds to an epitope comprising an amino acid encoded by rsl367117, rsl041973 and rs398829. In specific embodiments, the osteoarthritis directed molecule interacts with, a nucleic acid or polypeptide variant associated with osteoarthritis, such as variants referenced herein. In other embodiments, the osteoarthritis directed molecule interacts with a polypeptide involved ir a signal pathway of a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAA4TS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a nucleic acid comprising such a nucleotide sequence. [0120] Compositions sometimes include an adjuvant known to stimulate an immune response, and in certain embodiments, an adjuvant that stimulates a T-cell lymphocyte response. Adjuvants are known, including but not limited to an aluminum adjuvant (e.g., aluminum hydroxide); a cytokine adjuvant or adjuvant that stimulates a cytokine response (e.g., interleukin (IL)-12 and/or gamma- interferon cytokines); a Freund-type mineral oil adjuvant emulsion (e.g., Freund's complete or incomplete adjuvant); a synthetic lipoid compound; a copolymer adjuvant (e.g., TitreMax); a saponin; Quil A; a liposome; an oil-in- water emulsion (e.g: , an emulsion stabilized by Tween 80 and pluronic polyoxyethlene/polyoxypropylene block copolymer (Syntex Adjuvant Formulation); TitreMax; detoxified endotoxin (MPL) and mycobacterial cell wall components (TDW, CWS) in 2% squalene (Ribi Adjuvant System)); a muramyl dipeptide; an immune-stimulating complex (ISCOM, e.g., an Ag- modified saponin/cholesterol micelle that forms stable cage-like structure); an aqueous phase adjuvant that does not have a depot effect (e.g., Gerbu adjαivant); a carbohydrate polymer (e.g., AdjuPrime); L- tyrosine; a manide-oleate compound (e.g., Montanide); an ethylene-vinyl acetate copolymer (e.g., Elvax 40W1,2); or lipid A, for example. Such compositions are useful for generating an immune response against osteoarthritis directed molecule (e.g., an "HLA-binding subsequence within a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence). In such methods, a peptide having an amino acid subsequence of a polypeptide encoded by a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence is delivered to a subject, where the subsequence binds to an HLA molecule and induces a CTL lymphocyte response. The peptide sometimes is delivered to the subject as an isolated peptide or as a minigene in a plasmid that encodes the peptide. Methods for identifying HLA-binding subsequences in such polypeptides are known (see e.g., publication WO02/20616 and PCT application US98/01373 for methods of identifying such sequences). [0121] The cell may be in a group of cells cultured in vitro or in a tissue maintained in vitro or present in an animal in vivo (e.g., a rat, mouse, ape or human). In certain embodiments, a composition comprises a component from a cell such as a nu leic acid molecule (e.g., genomic DNA), a protein mixture or isolated protein, for example. The aforementioned compositions have utility in diagnostic, prognostic and pharmacogenomic methods described previously and in therapeutics described hereafter. Certain osteoarthritis directed molecules are described in greater detail below.
Compounds [0122] Compounds can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; peptoid libraries (libraries of molecules having the functionalities of peptides, but with a novel, non-peptide backbone which are resistant to enzymatic degradation but which nevertheless remain bioactive (see, e.g., Zuckermann et al., J. Med. Chem.37: 2678-85 (1994)); spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; "one-bead one-compound" library methods; and synthetic library methods using affinity chromatography selection.. Biological library and peptoid library approaches are typically limited to peptide libraries, while the other approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam, Anticancer Drug Des. 12: 145, (1997)). Examples of methods for synthesizing molecular libraries are described, for example, in DeWitt et al., Proc. Natl. Acad. Sci. U.S.A. 90: 6909 (1993); Erb et al., Proc. Natl. Acad. Sci. USA 91: 11422 (1994); Zuckermann et al., J. Med. Chem. 37: 2678 (1994); Cho et al., Science 261 : 1303 (1993); Carrell et al., Angew. Chem. Int. Ed. Engl. 33: 2059 (1994); Carell et al., Angew. Chem. Int. Ed. Engl. 33: 2061 (1994); and in Gallop et al., J. Med. Chem. 37: 1233 (1994). [0123] Libraries of compounds may be presented in. solution (e.g., Houghten, Biotechniques 13: 412-421 (1992)), or on beads (Lam, Nature 354: 82-84 ( 1991)), chips (Fodor, Nature 364: 555-556 (1993)), bacteria or spores (Ladner, United States Patent No. 5,223,409), plasmids (Cull et al., Proc. Natl. Acad. Sci. USA 89: 1865-1869 (1992)) or on phage (Scott and Smith, Science 249: 386-390 (1990); Devlin, Science 249: 404-406 (1990); Cwirla et al., Proc. Natl. Acad. Sci. 87: 6378-6382 (1990); Felici, J. Mol. Biol. 222: 301-310 (1991); Ladner supra.). [0124] A compound sometimes alters expression and sometimes alters activity of a polypeptide target and may be a small molecule. Small molecules include, but are not limited to, peptides, peptidomimetics (e.g., peptoids), amino acids, amino acid analogs, polynucleotides, polynucleotide analogs, nucleotides, nucleotide analogs, organic or inorganic compounds (i.e., including heteroorganic and organometallic compounds) having a molecular weight less than about 10,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 5,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 1,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 500 grams per mole, and salts, esters, and other pharmaceutically acceptable forms of such compounds.
Antisense Nucleic Acid Molecules, Ribozymes. RNAi, siRNA and Modified Nucleic Acid Molecules [0125] An "antisense" nucleic acid refers to a nucleotide sequence complementary to a "sense" nucleic acid encoding a polypeptide, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. The antisense nucleic acid can be complementary to an entire coding strand, or to a portion thereof or a substantially identical sequence thereof. In another embodiment, the antisense nucleic acid molecule is antisense to a "noncoding region" of the coding strand of a nucleotide sequence (e.g., 5' and 3' untranslated regions in SEQ ID NO: 1-13 or a nucleotide sequence referenced in Table E5). [0126] An antisense nucleic acid can be designed such that it is complementary to the entire coding region of an mRNA encoded by a nucleotide sequence (e.g., SEQ ID NO: 1-13, SEQ ID NO: 14-36 or a nucleotide sequence referenced in Table B), and often the antisense nucleic acid is an oligonucleotide antisense to only a portion of a coding or noncoding region of the mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of the mRNA, e.g., between the -10 and +10 regions of the target gene nucleotide sequence of interest. An antisense oligonucleotide can be, for example, about 7, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, or more nucleotides in length. The antisense nucleic acids, which include the ribozymes described hereafter, can be designed to target a PADI2, APOB, IL1JRL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence, often a variant associated with osteoarthritis, or a substantially identical sequence thereof. Among the variants, minor alleles and major alleles can be targeted, and those associated with a higher risk of osteoarthritis are often designed, tested, and administered to subjects. [0127] An antisense nucleic acid can be constructed using chemical synthesis and enzymatic ligation reactions using standard procedures. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Antisense nucleic acid also can be produced biologically using an expression vector into whic-h a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection). [0128] When utilized as therapeutics, antisense nucleic acids typically are administered to a subject (e.g., by direct injection at a tissue site) or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a polypeptide and thereby inhibit expression of the polypeptide, for example, by inhibiting transcription and/or translation. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then are administered systemically. For systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, for example, by linking antisense nucleic acid molecules to peptides or antibodies which bind to cell surface receptors or antigens. Antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. Sufficient intracellular concentrations of antisense molecules are achieved by incorporating a strong promoter, such as a pol II or pol III promoter, in the vector construct. [0129] Antisense nucleic acid molecules sometimes are alpha-anomeric nucleic acid molecules. An alpha-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual beta-units, the strands run parallel to each other (Gaultier et al., Nucleic Acids. Res. 15: 6625-6641 (1987)). Antisense nucleic acid molecules can also comprise a 2'-o- methylribonucleotide (Inoue et al., Nucleic Acids Res. 15: 6131-6148 ( 1987)) or a chimeric RNA-DNA analogue (Inoue et al., FEBS Lett. 215: 327-330 (1987)). Antisense nucleic acids sometimes are composed of DNA or PNA or any other nucleic acid derivatives described previously. [0130] In another embodiment, an antisense nucleic acid is a ribozyme. A ribozyme having specificity for a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B can include one or more sequences complementary to such a nucleotide sequence, and a sequence having a known catalytic region responsible for mRNA cleavage (see e.g., U.S. Pat. No. 5,093,246 or Haselhoff and Gerlach, Nature 334: 585-591 (1988)). For example, a derivative of a Xetrahymena L-19 IVS RNA is sometimes utilized in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a mRNA (see e.g., Cech et al. U.S . Patent No. 4,987,071; and Cech et al. U.S. Patent No. 5, 116,742). Also, target mRNA sequences can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules (see e.g., Bartel & Szostak, Science 261 : 1411-1418 (1993)). [0131] Osteoarthritis directed molecules include in certain embodiments nucleic acids that can form triple helix structures with a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a substantially identical sequence thereof, especially one that includes a regulatory region that controls expression of a polypeptide. Gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of a nucleotide sequence referenced herein or a substantially identical sequence (e.g., promoter and/or enhancers) to form triple helical structures that prevent transcription of a gene in target cells (see e.g., Helene, Anticancer Drug Des. 6(6): 569-84 (1991); Helene et al., Ann. N.Y. Acad. Sci. 660: 27-36 (1992); and Maher, Bioassays 14(12): 807-15 (1992). Potential sequences that can be targeted for triple helix formation can be increased by creating a so-called "switchback" nucleic acid molecule. Switchback molecules are synthesized in an alternating 5'-3 ', 3 '-5' manner, such that they base pair with first one strand of a duplex and then the other, eliminating the necessity for a sizeable stretch of either purines or pyrimidines to be present on one strand of a duplex. [0132] Osteoarthritis directed molecules include RNAi and siRNA nncleic acids. Gene expression may be inhibited by the introduction of double-stranded RNA (dsRNA), which induces potent and specific gene silencing, a phenomenon called RNA interference or RNAi. See, e.g., Fire et al., US Patent Number 6,506,559; Tuschl et al. PCT International Publication No . WO 01/75164; Kay et al. PCT International Publication No. WO 03/010180A1; or Bosher JM, Labouesse, Nat Cell Biol 2000 Feb;2(2):E31-6. This process has been improved by decreasing the size of the double-stranded RNA to 20-24 base pairs (to create small-interfering RNAs or siRNAs) that "switched off genes in mammalian cells without initiating an acute phase response, i.e., a host defense mechanism that often results in cell death (see, e.g., Caplen et al. Proc Natl Acad Sci U S A. 2001 Aug 14;98(T7):9742-7 and Elbashir et al. Methods 2002 Feb;26(2): 199-213). There is increasing evidence of post-transcriptional gene silencing by RNA interference (RNAi) for inhibiting targeted expression in mammalian cells at the mRNA level, in human cells. There is additional evidence of effective methods for inhibiting the proliferation and migration of tumor cells in human patients, and for inhibiting metastatic cancer development (see, e.g., U.S. Patent Application No. US2001000993183; Caplen et al. Proc Natl Acad Sci U S A; and Abderrahmani et al. Mol Cell Biol 2001 Nov21(21):7256-67). [0133] An "siRNA" or "RNAi" refers to a nucleic acid that forms a double stranded RNA and has the ability to reduce or inhibit expression of a gene or target gene when the siRNA is delivered to or expressed in the same cell as the gene or target gene. "siRNA" refers to short double-stranded RNA formed by the complementary strands. Complementary portions of the silRNA that hybridize to form the double stranded molecule often have substantial or complete identity to the target molecule sequence. In one embodiment, an siRNA refers to a nucleic acid that has substantial or complete identity to a target gene and forms a double stranded siRNA. [0134] When designing the siRNA molecules, the targeted region often is selected from a given DNA sequence beginning 50 to 100 nucleotides downstream of the start codon. See, e.g., Elbashir et al,. Methods 26:199-213 (2002). Initially, 5' or 3' UTRs and regions nearby the start codon were avoided assuming that UTR-binding proteins and/or translation initiation complexes may interfere with binding of the siRNP or RISC endonuclease complex. Sometimes regions of the target 23 nucleotides in length conforming to the sequence motif AA(N19)TT (N, an nucleotide), and regions with approximately 30%> to 70% G/C-content (often about 50% G/C-content) often are selected.. If no suitable sequences are found, the search often is extended using the motif NA(N21). The sequence of the sense siRNA sometimes corresponds to (N19) TT or N21 (position 3 to 23 of the 23-nrt motif), respectively. In the latter case, the 3' end of the sense siRNA often is converted to TT. Tϊie rationale for this sequence conversion is to generate a symmetric duplex with respect to the sequence composition of the sense and antisense 3' overhangs. The antisense siRNA is synthesized as the complement to position 1 to 21 of the 23-nt motif. Because position 1 of the 23-nt motif is not recognized sequence- specifically by the antisense siRNA, the 3'-most nucleotide residue of the antisense siRNA can be chosen deliberately. However, the penultimate nucleotide of the antisense siRNA (complementary to position 2 of the 23-nt motif) often is complementary to the targeted sequence. For simplifying chemical synthesis, TT often is utilized. siRNAs corresponding to the target motif NAR(TN" 17) YNN, where R is purine (A,G) and Y is pyrimidine (C,U), often are selected. Respective 21 nucleotide sense and antisense siRNAs often begin with a purine nucleotide and can also be expressed from pol III expression vectors without a change in targeting site. Expression of RNAs from pol III promoters often is efficient when the first transcribed nucleotide is a purine. [0135] The sequence of the siRNA can correspond to the full length target gene, or a subsequence thereof. Often, the siRNA is about 15 to about 50 nucleotides in length (e.g., each complementary sequence of the double stranded siRNA is 15-50 nucleotides in length, and the double stra-nded siRNA is about 15-50 base pairs in length, sometimes about 20-30 nucleotides in length or about 20-25 nucleotides in length, e.g., 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides in lengtli. The siRNA sometimes is about 21 nucleotides in length. Methods of using siRNA are well known in the art, and specific siRNA molecules may be purchased from a number of companies including Dharmacon Research, Inc. [0136] Antisense, ribozyme, RNAi and siRNA nucleic acids can be altered to form modified nucleic acid molecules. The nucleic acids can be altered at base moieties, sugar moieties or phosphate backbone moieties to improve stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of nucleic acid molecules can be modified to generate peptide nucleic acids (see Hyrup et al, Bioorganic & Medicinal Chemistry 4 (1): 5-23 (1996)). As used r erein, the terms "peptide nucleic acid" or "PNA" refers to a nucleic acid mimic such as a DNA mim-ic, in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only trie four natural nucleobases are retained. The neutral backbone of a PNA can allow for specific hybridization to DNA and RNA under conditions of low ionic strength. Synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described, for example, in Hyrup et al. , (1996) supra and Perry-O'Keefe et al., Proc. Natl. Acad. Sci. 93: 14670-675 (1996). [0137] PNA nucleic acids can be used in prognostic, diagnostic, and therapeutic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of" gene expression by, for example, inducing transcription or translation arrest or inhibiting replication. PNA nucleic acid molecules can also be used in the analysis of single base pair mutations in a gene, (e.g., by PNA-directed PCR clamping); as "artificial restriction enzymes" when used in combination with other enzymes, (e.g., SI nucleases (Hyrup (1996) supra)); or as probes or primers for DNA sequencing or hybridization (Hyrup et al., (1996) supra; Perry-O'Keefe supra). [0138] In other embodiments, oligonucleotides may include other appended groups such as peptides (e.g. , for targeting host cell receptors in vivo), or agents facilitating transport across cell membranes (see e.g., Letsinger et al., Proc. Natl. Acad. Sci. USA 86: 6553-6556 (1989); Lema tre et al., Proc. Natl. Acad. Sci. USA 84: 648-652 (1987); PCT Publication No. W088/09810) or the blood-brain barrier (see, e.g., PCT Publication No. W089/10134). In addition, oligonucleotides can be modified with hybridization-triggered cleavage agents (See, e.g., Krol et al., Bio-Techniques 6: 958-976 C 1988)) or intercalating agents. (See, e.g., Zon, Pharm. Res. 5: 539-549 (1988) ). To this end, the oligonucleotide may be conjugated to another molecule, (e.g., a peptide, hybridization triggered cross- linking agent, transport agent, or hybridization-triggered cleavage agent). [0139] Also included herein are molecular beacon oligonucleotide primer and probe mole ules having one or more regions complementary to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, AD MTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B, or a substantially identical sequence thereof, two complementary regions, one having a fluorophore and one a quencher such that the molecular beacon is useful for quantifying the presence of the nucleic acid in a sample. Molecular beacon nucleic acids are described, for example, in Lizardi et al., U.S. Patent No. 5,854,033; Nazarenko et al., U.S. Patent No. 5,866,336, and Livak et al., U.S. Patent 5,876,930.
Antibodies [0140] The term "antibody" as used herein refers to an immunoglobulin molecule or immunologically active portion thereof, i.e., an antigen-binding portion. Examples of immunologically active portions of immunoglobulin molecules include F(ab) and F(ab')2 fragments which can be generated by treating the antibody with an enzyme such as pepsin. An antibody sometimes is a polyclonal, monoclonal, recombinant (e.g., a chimeric or humanized), fully human, non-human (e.g., murine), or a single chain antibody. An antibody may have effector function and can fix complement, and is sometimes coupled to a toxin or imaging agent. [0141] A full-length polypeptide or antigenic peptide fragment encoded by a nucleotide sequence referenced herein can be used as an immunogen or can be used to identify antibodies made with other immunogens, e.g., cells, membrane preparations, and the like. An antigenic peptide often includes at least 8 amino acid residues of the amino acid sequences encoded by a nucleotide sequence referenced herein, or substantially identical sequence thereof, and encompasses an epitope. Antigenic peptides sometimes include 10 or more amino acids, 15 or more amino acids, 20 or more amino acids, or 30 or more amino acids. Hydrophilic and hydrophobic fragments of polypeptides sometimes are used as immunogens. [0142] Epitopes encompassed by the antigenic peptide are regions located on the surface of the polypeptide (e.g., hydrophilic regions) as well as regions with high antigenicity. For example, an Emini surface probability analysis of the human polypeptide sequence can be used to indicate the regions that have a particularly high probability of being localized to the surface of the polypeptide and are thus likely to constitute surface residues useful for targeting antibody production. The antibody may bind an epitope on any domain or region on polypeptides described herein. [0143] Also, chimeric, humanized, and completely human antibodies are useful for applications which include repeated administration to subjects. Chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, can be made using standard recombinant DNA techniques. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art, for example using methods described in Robinson et al International Application No. PCT/US86/02269; Akira, et al European Patent Application 184,187; Taniguchi, M., European Patent Application 171,496; Morrison et al European Patent Application 173,494; Neuberger et al PCT International Publication No. WO 86/01533; Cabilly et al U.S. Patent No. 4,816,567; Cabilly et al European Patent Application 125,023; Better et al., Science 240: 1041-1043 (1988); Liu et al., Proc. Natl. Acad. Sci. USA 84: 3439-3443 (1987); Liu et al., J. Immunol. 139: 3521-3526 (1987); Sum et al., Proc. Natl. Acad. Sci. USA 84: 214-218 (1987); Nishimura et al., Cane. Res. 47: 999-1005 (1987); Wood et al., Nature 314: 446-449 (1985); and Shaw et al., J. Natl. Cancer Inst. 80: 1553-1559 (1988); Morrison, S. L., Science 229: 1202-1207 (1985); Oi et al., BioTechniques 4: 214 (1986); Winter U.S. Patent 5,225,539; Jones et al., Nature 321: 552-525 (1986); Verhoeyan et al., Science 239* : 1534; and Beidler et al., J. Immunol. 141 : 4053-4060 (1988). [0144] Completely human antibodies are particularly desirable for therapeutic treatment of human patients. Such antibodies can be produced using transgenic mice that are incapable of expressing endogenous immunoglobulin heavy and light chains genes, but which can express human heavy and light chain genes. See, for example, Lonberg and Huszar, Int. Rev. Immunol. 13: 65-93 (1995); and U.S. Patent Nos. 5,625,126; 5,633,425; 5,569,825; 5,661,016; and 5,545,806. In addition, companies such as Abgenix, Inc. (Fremont, CA) and Medarex, Inc. (Princeton, NJ), can be engaged to provide human antibodies directed against a selected antigen using technology similar to that described above. Completely human antibodies that recognize a selected epitope also can be generated using a technique referred to as "guided selection." In this approach a selected non-human monoclonal antibody (e.g., a murine antibody) is used to guide the selection of a completely human antibody recognizing the same epitope. This technology is described for example by Jespers et al, Bio/Technology 12: 899-903 (1994). [0145] An antibody can be a single chain antibody. A single chain antibody (scFV) can be engineered (see, e.g., Colcher et al., Ann. N Y Acad. Sci. 880: 263-80 (1999); and Reiter, Clin. Cancer Res. 2: 245-52 (1996)). Single chain antibodies can be dimerized or multimerized to generate multivalent antibodies having specificities for different epitopes of the same target polypeptide. [0146] Antibodies also may be selected or modified so that they exhibit reduced or no ability to bind an Fc receptor. For example, an antibody may be an isotype or subtype, fragment or other mutant, which does not support binding to an Fc receptor (e.g., it has a mutagenized or deleted Fc receptor binding region). [0147] Also, an antibody (or fragment thereof) may be conjugated to a therapeutic moiety such as a cytotoxin, a therapeutic agent or a radioactive metal ion. A cytotoxin or cytotoxic agent includes any agent that is detrimental to cells. Examples include taxol, cytochalasin B, gramicidin D, ethidium bromide, emetine, mitomycin, etoposide, tenoposide, vincristine, vinblastine, colchicin, doxorubicin, daunorubicin, dihydroxy anthracin dione, mitoxantrone, mithramycin, actinomycin D, 1 dehydrotestosterone, glucocorticoids, procaine, tetracaine, lidocaine, propranolol, and puromycin and analogs or homologs thereof. Therapeutic agents include, but are not limited to, antimetabolites (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), alkylating agents (e.g., mechlorethamine, thiotepa chlorambucil, melphalan, carmustine (BCNU) and lomustine (CCNU), cyclophosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis- dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g., vincristine and vinblastine). [0148] Antibody conjugates can be used for modifying a given biological response. For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity. Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a polypeptide such as tumor necrosis factor, gamma-interferon, alpha-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 ("IL-1"), interleukin-2 ("IL-2"), interleukin-6 ("IL-6"), granulocyte macrophage colony stimulating factor ("GM-CSF"), granulocyte colony stimulating factor ("G-CSF"), or other growth factors. Also, an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Patent No. 4,676,980, for example. [0149] An antibody (e.g., monoclonal antibody) can be used to isolate target polypeptides by standard techniques, such as affinity chromatography or immunoprecipitation. Moreover, an antibody can be used to detect a target polypeptide (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the polypeptide. Antibodies can be used diagnostically to monitor polypeptide levels in tissue as part of a clinical testing procedure, e.g., to determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance (i.e., antibody labeling). Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and. aequorin, and examples of suitable radioactive material include 1251, 1311, 35S or 3H. Also, an antibody can be utilized as a test molecule for determining whether it can treat osteoarthritis, and as a therapeutic for administration to a subject for treating osteoarthritis. [0150] An antibody can be made by immunizing with a purified antigen, or a fragment thereof, e.g., a fragment described herein, a membrane associated antigen, tissues, e.g., crude tissue prepajrations, whole cells, preferably living cells, lysed cells, or cell fractions. [0151] Included herein are antibodies which bind only a native polypeptide, only denatured or otherwise non-native polypeptide, or which bind both, as well as those having linear or conforma'tional epitopes. Conformational epitopes sometimes can be identified by selecting antibodies that bind to native but not denatured polypeptide. Also featured are antibodies that specifically bind to a polypeptide variant associated with osteoarthritis.
Methods for Identifying Candidate Therapeutics for Treating Osteoarthritis [0152] Current therapies for the treatment of osteoarthritis have limited efficacy, limited tolerability and significant mechanism-based side effects, and few of the available therapies adequately address underlying defects. Current therapeutic approaches were largely developed in the absence of defined molecular targets or even a solid understanding of disease pathogenesis. Therefore, provided are methods of identifying candidate therapeutics that target biochemical pathways related to the development of osteoarthritis. [0153] Thus, featured herein are methods for identifying a candidate therapeutic for treating osteoarthritis. The methods comprise contacting a test molecule with a target molecule in a system. A "target molecule" as used herein refers to a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleotide sequence referenced in Table B, a substantially identical nucleic acid thereof, or a fragment thereof, and an encoded polypeptide of the foregoing. The methods also comprise determining the presence or absence off an interaction between the test molecule and the target molecule, where the presence of an interaction between the test molecule and the nucleic acid or polypeptide identifies the test molecule as a cai didate osteoarthritis therapeutic. The interaction between the test molecule and the target molecule may be quantified. [0154] Test molecules and candidate therapeutics include, but are not limited to, compounds. , antisense nucleic acids, siRNA molecules, ribozymes, polypeptides or proteins encoded by a PALDI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleotide sequence or other nucleotide sequence referenced in Table B , or a substantially identical sequence or fragment thereof, and immunotherapeutics (e.g., antibodies and HLA-presented polypeptide fragments). A test molecule or candidate therapeutic may act as a modulator of target molecule concentration or target molecule function in a system. A "modulator" may agonize (i.e., up-regulates) or antagonize (i.e., down-regulates) a target molecule concentration partially or completely in a system by affecting such cellular functions as DNA replication and/or DNA processing (e.g., DNA methylation or DNA repair), RNA transcription and/or RNA processing (e.g., removal of intronic sequences and/or translocation of spliced mRNA from the nucleus), polypeptide production (e.g., translation of the polypeptide from mRNA), and/or polypeptide post-translational modification (e.g., glycosylation, phosphorylation, and proteolysis of pro-polypeptides). A modulator may also agonize or antagonize a biological function of a target molecule partially or completely, where the function may include adopting a certain structural conformation, interacting with one or more binding partners, ligand binding, catalysis (e.g., phosphorylation, dephosphorylation, hydrolysis, methylation, and isomerization), and an effect upon a cellular event (e.g., effecting progression of osteoarthritis). Any modulator may be utilized, such as a peptidyl arginine deiminase modulator (e.g., PADI2 likely is a peptidyl arginine deiminase) described in WO-09851784 and WO0244360A2 or an apolipoprotein (e.g., APOB includes an apolipoprotein domain) modulatory compound (e.g., WO-2004017969, WO- 03002533, US 6,369,075, WO-02098839, WO-02098871, WO-00177077, WO-00153260, WO- 00105767), antibody (e.g., WO-9600903A1, US 6,309,844 and US 5,330,910) or antisense molecule (e.g., WO03011887A2 and WO03097662A1). [0155] As used herein, the term "system" refers to a cell free in vitro environment and a cell-based environment such as a collection of cells, a tissue, an organ, or an organism. A system is "contacted-" with a test molecule in a variety of manners, including adding molecules in solution and allowing them to interact with one another by diffusion, cell injection, and any administration routes in an animal. As used herein, the term "interaction" refers to an effect of a test molecule on test molecule, where the effect sometimes is binding between the test molecule and the target molecule, and sometimes is an observable change in cells, tissue, or organism. [0156] There are many standard methods for detecting the presence or absence of interaction between a test molecule and a target molecule. For example, titrametric, acidimetric, radiometric, NMR, mono layer, polarographic, spectrophotometric, fluorescent, and ESR assays probative of a target molecule interaction may be utilized. Examples of G protein-coupled receptor assays are known, for example, and are described in WO-0242461 and WO-04013285. [0157] ADAMTS2 activity and/or ADAMTS2 interactions can be detected and quantified using assays known in the art. For example, an immunoprecipitation assay or a kinase activity assay that employs a kinase-inactivated MEK can be utilized. Kinase inactivated MEKs are known in the art, such as a MEK that includes the mutation K97M. In these assays, mammalian cells (e.g., COS or NIH-3T3) are transiently transfected with constructs expressing ADAMTS2, and in addition, the cells are co- transfected with oncogenic RAS or SRC or both. Oncogenic RAS or SRC activates ADAMTS2 kinase activity. ADAMTS2 is immunoprecipitated from cell extracts using a monoclonal antibody (e.g., 9E 10) or a polyclonal antibody (e.g., from rabbit) specific for a unique peptide from ADAMTS2. ADAMTS'2 is then resuspended in assay buffer containing GST-Mekl or GST-Mek2 and/or GST-ERK2. In addition, [gamma 32P] ATP can be added to detect and/or quantify phosphorylation activity. Samples are incubated for 5-30 minutes at 30°C, and then the reaction is terminated by addition of EDTA. TJhe samples are centrifuged and the supernatant fractions are collected. Phosphorylation activity is detected using one of two methods: (i) activity of GST-ERK2 kinase can be measured using MBP (myelixi basic protein, a substrate for ERK) as substrate, or (ii) following incubation of immunoprecipitated ADAMTS2 in reaction buffer containing GST-ERK and [gamma 32P] ATP, transfer of labeled ATP to kinase-dead ERK can be quantified by a phosphor-imager or densitometer following PAGE separation of polypeptide products (phosphorylated and non-phosphorylated forms). These types of assays are described in Weber et al, Oncogene 19: 169-176 (2000); Mason et al., EMBO J. 18: 2137-2148 (1999); Marais et al, J. Biol. Chem. 272: 4378-4383 (1997); Marais et al, EMBO J. 14: 3136-3145 (19S 5). [0158] As noted above, ADAMTS2 includes a domain having metalloprotease activity, and modulators of such activity are known. Examples of such modulators are set forth in WO03063762A2; WO-09937625; WO-09918076; WO-09838163; WO-09837877; WO9947550A1; WO0177092AJ; WO0040577A1; W09942436A1; W09838163A1; W09837877A1; WO04014379A1; WO03106381A2; WO03014098A1; WO03014092A1 and WO02096426A1. [0159] Test molecule/target molecule interactions can be detected and/or quantified using assays known in the art. For example, an interaction can be determined by labeling the test molecule and/or the target molecule, where the label is covalently or non-covalently attached to the test molecule or target molecule. The label is sometimes a radioactive molecule such as I, I, S or H, which can be detected by direct counting of radioemission or by scintillation counting. Also, enzymatic labels such as horseradish peroxidase, alkaline phosphatase, or luciferase may be utilized where the enzymatic label can be detected by determining conversion of an appropriate substrate to product. In addition, presence or absence of an interaction can be determined without labeling. For example, a microphysiometer (e.g., Cytosensor) is an analytical instrument that measures the rate at which a cell acidifies its environment using a light-addressable potentiometric sensor (LAPS). Changes in this acidificati n rate can be used as an indication of an interaction between a test molecule and target molecule (McConnell, H. M. et al, Science 257: 1906-1912 (1992)). [0160] In cell-based systems, cells typically include a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleotide sequence referenced in Table B, an encoded polypeptide, or substantially identical nucleic acid or polypeptide thereof, and are often of mammalian origin, although the cell can be of any origin. Whole cells, cell homogenates, and cell fractions (e.g., cell membrane fractions) can be subjected to analysis. Wh-ere interactions between a test molecule with a target polypeptide are monitored, soluble and/or membrane bound forms of the polypeptide may be utilized. Where membrane-bound forms of the polypeptide are used, it may be desirable to utilize a solubilizing agent. Examples of such solubilizing agents include non-ionic detergents such as n-octylglucoside, n-dodecylglucoside, n-dodecylmaltoside, octanoyl-N- methylglucamide, decanoyl-N-methylglucamide, Triton® X-100, Triton® X-114, Thesit®, Isotridecypoly(ethylene glycol ether)n, 3-[(3-cholamidopropyl)dimethylamminio]-l -propane sulfonate
(CHAPS), 3-[(3-cholamidopropyl)dimethylamminio]-2-hydroxy-l-propane sulfonate (CHAPSO), or N- dodecyl-N,N-dimethyl-3-ammonio-l-propane sulfonate. [0161] An interaction between a test molecule and target molecule also can be detected by monitoring fluorescence energy transfer (FET) (see, e.g., Lakowicz et al, U.S. Patent No. 5,631,169; Stavrianopoulos et al. U.S. Patent No. 4,868,103). A fluorophore label on a first, "donor" molecule is selected such that its emitted fluorescent energy will be absorbed by a fluorescent label on a second, "acceptor" molecule, which in turn is able to fluoresce due to the absorbed energy. Alternately, the "donor" polypeptide molecule may simply utilize the natural fluorescent energy of tryptophan residues. Labels are chosen that emit different wavelengths of light, such that the "acceptor" molecule label may be differentiated from that of the "donor". Since the efficiency of energy transfer between the labels is related to the distance separating the molecules, the spatial relationship between the molecules can be assessed. In a situation in which binding occurs between the molecules, the fluorescent emission of the "acceptor" molecule label in the assay should be maximal. An FET binding event can be conveniently measured through standard fluorometric detection means well known in the art (e.g., using a fluorimeter). [0162] In another embodiment, determining the presence or absence of an interaction between a test molecule and a target molecule can be effected by monitoring surface plasmon resonance (see, e.g., Sjolander & Urbaniczk, Anal. Chem. 63: 2338-2345 (1991) and Szabo et al, Curr. Opin. Struct. Biol 5: 699-705 (1995)). "Surface plasmon resonance" or "biomolecular interaction analysis (BIA)" can be utilized to detect biospecific interactions in real time, without labeling any of the interactants (e.g., BIAcore). Changes in the mass at the binding surface (indicative of a binding event) result in alterations of the refractive index of light near the surface (the optical phenomenon of surface plasmon resonance (SPR)), resulting in a detectable signal which can be used as an indication of real-time reactions between biological molecules. [0163] In another embodiment, the target molecule or test molecules are anchored to a solid phase, facilitating the detection of target molecule/test molecule complexes and separation of the complexes from free, uncomplexed molecules. The target molecule or test molecule is immobilized to the solid support. In an embodiment, the target molecule is anchored to a solid surface, and the test molecule, which is not anchored, can be labeled, either directly or indirectly, with detectable labels discussed herein. [0164] It may be desirable to immobilize a target molecule, an anti-target molecule antibody, and/or test molecules to facilitate separation of target molecule/test molecule complexes from uncomplexed forms, as well as to accommodate automation of the assay. The attachment between a test molecule and/or target molecule and the solid support may be covalent or non-covalent (see, e.g., U.S.
Patent No. 6,022,688 for non-covalent attachments). The solid support may be one or more surfaces of the system, such as one or more surfaces in each well of a microtiter plate, a surface of a silicon wafer, a surface of a bead (see, e.g., Lam, Nature 354: 82-84 (1991)) that is optionally linked to another solid support, or a channel in a microfluidic device, for example. Types of solid supports, linker molecules for covalent and non-covalent attachments to solid supports, and methods for immobilizing nucleic acids and other molecules to solid supports are well known (see, e.g., U.S. Patent Nos. 6,261,776; 5,900,481; 6,133,436; and 6,022,688; and WIPO publication WO 01/18234). [0165] In an embodiment, target molecule may be immobilized to surfaces via biotin and streptavidin. For example, biotinylated target polypeptide can be prepared from biotin-NHS (N- hydroxy-succinimide) using techniques known in the art (e.g., biotinylation kit, Pierce Chemicals, Rockford, IL), and immobilized in the wells of streptavidin-coated 96 well plates (Pierce Chemical). In another embodiment, a target polypeptide can be prepared as a fusion polypeptide. For example, glutathione-S-transferase/target polypeptide fusion can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, MO) or glutathione derivitized microtiter plates, which are then combined with a test molecule under conditions conducive to complex formation (e.g. , at physiological conditions for salt and pH). Following incubation, the beads or microtiter plate wells are washed to remove any unbound components, or the matrix is immobilized in the case of beads, and complex formation is determined directly or indirectly as described above. Alternatively, the complexes can be dissociated from the matrix, and the level of target molecule binding or activity is determined using standard techniques. [0166] In an embodiment, the non-immobilized component is added to the coated surface containing the anchored component. After the reaction is complete, unreacted components are removed (e.g., by washing) under conditions such that a significant percentage of complexes formed will remain immobilized to the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of manners. Where the previously non-immobilized component is pre- labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the previously non-immobilized component is not pre-labeled, an indirect lab l can be used to detect complexes anchored on the surface, e.g., by adding a labeled antibody specific for the immobilized component, where the antibody, in turn, can be directly labeled or indirectly labeled with, e.g., a labeled anti-Ig antibody. [0167] In another embodiment, an assay is performed utilizing antibodies that specifically bind target molecule or test molecule but do not interfere with binding of the target molecule to the test molecule. Such antibodies can be derivitized to a solid support, and unbound target molecule may be immobilized by antibody conjugation. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the target molecule, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the target molecule. [0168] Cell free assays also can be conducted in a liquid phase. In such an assay, reaction products are separated from unreacted components, by any of a number of standard techniques, including but not limited to: differential centrifugation (see, e.g., Rivas, G, and Minton, Trends Biochem Sci Aug; 18(8): 284-7 (1993)); chromatography (gel filtration chromatography, ion-exchange chromatography); electrophoresis (see, e.g., Ausubel et al, eds. Current Protocols in Molecular Biology , J. Wiley: New York (1999)); and immunoprecipitation (see, e.g, Ausubel et al, eds., supra). Media and chromatographic techniques are known to one skilled in the art (see, e.g., Heegaard, JMol Recognit. Winter; 11(1-6): 141-8 (1998); Hage & Tweed, J. Chromatogr. B Biomed. Sci. Appl Oct 10; 699 (1-2): 499-525 (1997)). Further, fluorescence energy transfer may also be conveniently utilized, as described herein, to detect binding without further purification of the complex from solution. [0169] In another embodiment, modulators of target molecule expression are identified. For example, a cell or cell free mixture is contacted with a candidate compound and the expression of target mRNA or target polypeptide is evaluated relative to the level of expression of target mRNA o>r target polypeptide in the absence of the candidate compound. When expression of target mRNA or target polypeptide is greater in the presence of the candidate compound than in its absence, the candidate compound is identified as an agonist of target mRNA or target polypeptide expression. Alternatively, when expression of target mRNA or target polypeptide is less (e.g., less with statistical significance) in the presence of the candidate compound than in its absence, the candidate compound is identified as an antagonist or inhibitor of target mRNA or target polypeptide expression. The level of target rnRNA or target polypeptide expression can be determined by methods described herein. [0170] In another embodiment, binding partners that interact with a target molecule are detected. The target molecules can interact with one or more cellular or extracellular macromolecules, such as polypeptides in vivo, and these interacting molecules are referred to herein as "binding partners." Binding partners can agonize or antagonize target molecule biological activity. Also, test mo lecules that agonize or antagonize interactions between target molecules and binding partners can be useful as therapeutic molecules as they can up-regulate or down-regulated target molecule activity in vivo and thereby treat osteoarthritis. [0171] Binding partners of target molecules can be identified by methods known in the art. For example, binding partners may be identified by lysing cells and analyzing cell lysates by electrophoretic techniques. Alternatively, a two-hybrid assay or three-hybrid assay can be utilized (see, e.g., U.S. Patent No. 5,283,317; Zervos et al, Cell 72:223-232 (1993); Madura et al, J. Biol. Chem. 2&8: 12046- 12054 (1993); Bartel et al, Biotechniques 14: 920-924 (1993); Iwabuchi et al, Oncogene 8: 1693-1696 (1993); and Brent WO94/10300). A two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. The assay often utilizes two different DNA constructs. In one construct, a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B (sometimes referred to as the "bait") is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In another construct, a DNA sequence from a library of DNA sequences that encodes a potential binding partner (sometimes referred to as the "prey") is fused to a gene that encodes an activation domain of the known transcription factor. Sometimes, a PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 or APOL3 nucleic acid or other nucleic acid referenced in Table B can be fused to the activation domain. If the "bait" and the "prey" molecules interact in vivo, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene ^. ., LacZ) which is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to identify the potential binding partner. [0172] In an embodiment for identifying test molecules that antagonize or agonize complex formation between target molecules and binding partners, a reaction mixture containing the target molecule and the binding partner is prepared, under conditions and for a time sufficient to allow complex formation. The reaction mixture often is provided in the presence or absence of the test molecule. The test molecule can be included initially in the reaction mixture, or can be added at a time subsequent to the addition of the target molecule and its binding partner. Control reaction mixtures are incubated without the test molecule or with a placebo. Formation of any complexes between t e target molecule and the binding partner then is detected. Decreased formation of a complex in the rea-ction mixture containing test molecule as compared to in a control reaction mixture indicates that the molecule antagonizes target molecule/binding partner complex formation. Alternatively, increased formation of a complex in the reaction mixture containing test molecule as compared to in a control reaction mixture indicates that the molecule agonizes target molecule/binding partner complex formation. In another embodiment, complex formation of target molecule/binding partner can be compared to complex formation of mutant target molecule/binding partner (e.g., amino acid modifications in a target polypeptide). Such a comparison can be important in those cases where it is desirable to identify test molecules that modulate interactions of mutant but not non-mutated target gene products. [0173] The assays can be conducted in a heterogeneous or homogeneous format. In heterogeneous assays, target molecule and/or the binding partner are immobilized to a solid phase, and complexes are detected on the solid phase at the end of the reaction. In homogeneous assays, the entire reaction is carried out in a liquid phase. In either approach, the order of addition of reactants can be varied to obtain different information about the molecules being tested. For example, test compounds that agonize target molecule/binding partner interactions can be identified by conducting the reaction in the presence of the test molecule in a competition format. Alternatively, test molecules that agonize preformed complexes, e.g., molecules with higher binding constants that displace one of the components from the complex, can be tested by adding the test compound to the reaction mixture after complexes have been formed. [0174] In a heterogeneous assay embodiment, the target molecule or the binding partner is anchored onto a solid surface (e.g., a microtiter plate), while the non-anchored species is labeled, either directly or indirectly. The anchored molecule can be immobilized by non-covalent or covalent attachments. Alternatively, an immobilized antibody specific for the molecule to be anchored can be used to anchor the molecule to the solid surface. The partner of the immobilized species is exposed to the coated surface with or without the test molecule. After the reaction is complete, unreacted components are removed (e.g., by washing) such that a significant portion of any complexes formed will remain immobilized on the solid surface. Where the non-immobilized species is pre- labeled, the detection of label immobilized on the surface is indicative of complex. Where the non-immobilized species is not pre-labeled, an indirect label can be used to detect complexes anchored to t ie surface; e.g., by using a labeled antibody specific for the initially non-immobilized species. Depending upon the order of addition of reaction components, test compounds that inhibit complex formation or that disrupt preformed complexes can be detected. [0175] In another embodiment, the reaction can be conducted in a liquid phase in the presence or absence of test molecule, where the reaction products are separated from unreacted components, and the complexes are detected (e.g., using an immobilized antibody specific for one of the binding components to anchor any complexes formed in solution, and a labeled antibody specific for the other partner to detect anchored complexes). Again, depending upon the order of addition of reactants to the liquid phase, test compounds that inhibit complex or that disrupt preformed complexes can be identified. [0176] In an alternate embodiment, a homogeneous assay can be utilized. For example, a preformed complex of the target gene product and the interactive cellular or extracellular binding partner product is prepared. One or both of the target molecule or binding partner is labeled, and the signal generated by the label(s) is quenched upon complex formation (e.g., U.S. Patent No. 4,109,496 that utilizes this approach for immunoassays). Addition of a test molecule that competes with and displaces one of the species from the preformed complex will result in the generation of a signal above background. In this way, test substances that disrupt target molecule/binding partner complexes can be identified. [0177] Candidate therapeutics for treating osteoarthritis are identified from a group of test molecules that interact with a target molecule. Test molecules are normally ranked according to the degree with which they modulate (e.g., agonize or antagonize) a function associated with the target molecule (e.g., DNA replication and/or processing, RNA transcription and/or processing, polypeptide production and/or processing, and/or biological function/activity), and then top ranking modulators are selected. Also, pharmacogenomic information described herein can determine the rank of a modulator. The top 10% of ranked test molecules often are selected for further testing as candidate therapeutics, and sometimes the top 15%, 20%, or 25% of ranked test molecules are selected for further testing as candidate therapeutics. Candidate therapeutics typically are formulated for administration to a subject.
Therapeutic Formulations [0178] Formulations and pharmaceutical compositions typically include in combination with a pharmaceutically acceptable carrier one or more target molecule modulators. The modulator often is a test molecule identified as having an interaction with a target molecule by a screening method described above. The modulator may be a compound, an antisense nucleic acid, a ribozyme, an antibody, or a binding partner. Also, formulations may comprise a target polypeptide or fragment thereof in combination with a pharmaceutically acceptable carrier, where the polypeptide or fragment sometimes has an APOL3 biological activity (e.g., apolipoprotein activity), and sometimes includes all or part of an apolipoprotein domain. [0179] Formulations or pharmaceutical compositions typically include in combination with a pharmaceutically acceptable carrier, a compound, an antisense nucleic acid, a ribozyme, an antibody, a binding partner that interacts with an ADAMTS2 polypeptide, ADAMTS2 nucleic acid, or a fragment thereof. The formulated molecule may be one that is identified by a screening method described above. Also, formulations may comprise a ADAMTS2 polypeptide or fragment thereof, where the ADAMTS2 polypeptide contains an isoleucine at position 245 of SEQ ID NO: 44, and a pharmaceutically acceptable carrier. Also, formulations may comprise an active ADAMTS2 polypeptide or fragment thereof, where ADAMTS2 polypeptide fragments having activity are selected from amino acids 252- 1211, 253-1211, 254-1211, 255-1211, 256-1211, 257-1211, 258-1211, 259-1211 or 260-1211 of SEQ ID NO: 44, where it is understood that the active form of ADAMTS2 does not contain the propeptide domain. As used herein, the term "pharmaceutically acceptable carrier" includes solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. Supplementary active compounds can also be incorporated into the compositions. [0180] As used herein, the term "pharmaceutically acceptable carrier" includes solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. Supplementary active compounds can also be incorporated into the compositions. Pharmaceutical compositions can be included in a container, pack, or dispenser together with instructions for administration. [0181] A pharmaceutical composition typically is formulated to be compatible with its intended route of administration. Examples of routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, and rectal administration. Solutions or suspensions used for parenteral, intradermal, or subcutaneous application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerin, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose. pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic. [0182] Oral compositions generally include an inert diluent or an edible carrier. For the purpose of oral therapeutic administration, the active compound can be incorporated with excipients and used in the form of tablets, troches, or capsules, e.g., gelatin capsules. Oral compositions can also be prepared using a fluid carrier for use as a mouthwash. Pharmaceutically compatible binding agents, and/or adjuvant materials can be included as part of the composition. The tablets, pills, capsules, troches and the like can contain any of the following ingredients, or compounds of a similar nature: a binder such as microcrystaUine cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring. /[0183] Pharmaceutical compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. For intravenous administration, suitable carriers include physiological saline, bacteriostatic water, Cremophor EL™ (BASF, Parsippany, NJ) or phosphate buffered saline (PBS). In all cases, the composition must be sterile and should be fluid to the extent that easy syringability exists. It should be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as mannitol, sorbitol, sodium chloride in the composition. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate and gelatin. [0184] Sterile injectable solutions can be prepared by incorporating the active compound in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle which contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum drying and freeze-drying which yields a powder of the active ingredient plus any additional desired ingredient from a previously sterile- filtered solution thereof. [0185] For administration by inhalation, the compounds are delivered in the form of an aerosol spray from pressured container or dispenser which contains a suitable propeUant, e.g., a gas such as carbon dioxide, or a nebulizer. [0186] Systemic administration can also be by transmucosal or transdermal means. For transmucosal or transdermal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art, and include, for example, for transmucosal administration, detergents, bile salts, and fusidic acid derivatives. Transmucosal administration can be accomplished through the use of nasal sprays or suppositories. For transdermal administration, the active compounds are formulated into ointments, salves, gels, or creams as generally known in the art. Molecules can also be prepared in the form of suppositories (e.g., with conventional suppository bases such as cocoa butter and other glycerides) or retention enemas for rectal delivery. [0187] In one embodiment, active molecules are prepared with carriers that will protect the compound against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art. Materials can also be obtained commercially from Alza Corporation and Nova Pharmaceuticals, Inc. Liposomal suspensions (including liposomes targeted to infected cells with monoclonal antibodies to viral antigens) can also be used as pharmaceutically acceptable carriers. These can be prepared according to methods known to those skilled in the art, for example, as described in U.S. Patent No. 4,522,811. [0188] It is advantageous to formulate oral or parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. [0189] Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Molecules which exhibit high therapeutic indices are preferred. While molecules that exhibit toxic side effects may be used, care should be taken to design a delivery system that targets such compounds to the site of affected tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects. [0190] The data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such molecules lies preferably within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any molecules used in the methods described herein, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography. [0191] As defined herein, a therapeutically effective amount of protein or polypeptide (i.e., an effective dosage) ranges from about 0.001 to 30 mg/kg body weight, sometimes about 0.01 to 25 mg/kg body weight, often about 0.1 to 20 mg/kg body weight, and more often about 1 to 10 mg/kg, 2 to 9 mg/kg, 3 to 8 mg/kg, 4 to 7 mg/kg, or 5 to 6 mg/kg body weight. The protein or polypeptide can be administered one time per week for between about 1 to 10 weeks, sometimes between 2 to 8 weeks, often between about 3 to 7 weeks, and more often for about 4, 5, or 6 weeks. The skilled artisan will appreciate that certain factors may influence the dosage and timing required to effectively treat a subject, including but not limited to the severity of the disease or disorder, previous treatments, the general health and/or age of the subject, and other diseases present. Moreover, treatment of a subject with a therapeutically effective amount of a protein, polypeptide, or antibody can include a single treatment or, preferably, can include a series of treatments. [0192] With regard to polypeptide formulations, featured herein is a method for treating osteoarthritis in a subject, which comprises contacting one or more cells in the subject with a first polypeptide, where the subject comprises a second polypeptide having one or more polymorphic variations associated with cancer, and where the first polypeptide comprises fewer polymorphic variations associated with cancer than the second polypeptide. The first and second polypeptides are encoded by a nucleic acid which comprises a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence referenced in SEQ ID NO: 1-13 or referenced in Table B; a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-13 or referenced in Table B and a nucleotide sequence 90% or more identical to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B. The subject often is a human. [0193] For antibodies, a dosage of 0.1 mg/kg of body weight (generally 10 mg/kg to 20 mg/kg) is often utilized. If the antibody is to act in the brain, a dosage of 50 mg/kg to 100 mg/kg is often appropriate. Generally, partially human antibodies and fully human antibodies have a longer half-life within the human body than other antibodies. Accordingly, lower dosages and less frequent administration is often possible. Modifications such as lipidation can be used to stabilize antibodies and to enhance uptake and tissue penetration (e.g., into the brain). A method for lipidation of antibodies is described by Cruikshank et al, J. Acquired Immune Deficiency Syndromes and Human Retrovirology 14: 93 (1991). [0194] Antibody conjugates can be used for modifying a given biological response, the drug moiety is not to be construed as limited to classical chemical therapeutic agents. For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity. Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a polypeptide such as tumor necrosis factor, alpha-interferon, beta-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 ("IL-1"), interleukin-2 ("IL-2"), interleukin-6 ("IL-6"), granulocyte macrophage colony stimulating factor ("GM-CSF"), granulocyte colony stimulating factor ("G-CSF"), or other growth factors. Alternatively, an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Patent No. 4,676,980. [0195] For compounds, exemplary doses include milligram or microgram amounts of the compound per kilogram of subject or sample weight, for example, about 1 microgram per kilogram to about 500 milligrams per kilogram, about 100 micrograms per kilogram to about 5 milligrams per kilogram, or about 1 microgram per kilogram to about 50 micrograms per kilogram. It is understood that appropriate doses of a small molecule depend upon the potency of the small molecule with respect to the expression or activity to be modulated. When one or more of these small molecules is to be administered to an animal (e.g., a human) in order to modulate expression or activity of a polypeptide or nucleic acid described herein, a physician, veterinarian, or researcher may, for example, prescribe a relatively low dose at first, subsequently increasing the dose until an appropriate response is obtained. In addition, it is understood that the specific dose level for any particular animal subject will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, gender, and diet of the subject, the time of administration, the route of administration, the rate of excretion, any drug combination, and the degree of expression or activity to be modulated. [0196] With regard to nucleic acid formulations, gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (see, e.g., U.S. Patent 5,328,470) or by stereotactic injection (see e.g., Chen et al, (1994) Proc. Natl Acad. Sci. USA 97:3054-3057). Pharmaceutical preparations of gene therapy vectors can include a gene therapy vector in an acceptable diluent, or can comprise a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells (e.g., refroviral vectors) the pharmaceutical preparation can include one or more cells which produce the gene delivery system. Examples of gene delivery vectors are described herein.
Therapeutic Methods [0197] A therapeutic formulation described above can be administered to a subject in need of a therapeutic for inducing a desired biological response. Therapeutic formulations can be administered by any of the paths described herein. With regard to both prophylactic and therapeutic methods of treatment, such treatments may be specifically tailored or modified, based on knowledge obtained from pharmacogenomic analyses described herein. [0198] As used herein, the term "treatment" is defined as the application or administration of a therapeutic formulation to a subject, or application or administration of a therapeutic agent to an isolated tissue or cell line from a subject with the purpose to cure, heal, alleviate, relieve, alter, remedy, ameliorate, improve or affect osteoarthritis, symptoms of osteoarthritis or a predisposition towards osteoarthritis. A therapeutic formulation includes, but is not limited to, small molecules, peptides, antibodies, ribozymes and antisense oligonucleotides. Administration of a therapeutic formulation can occur prior to the manifestation of symptoms characteristic of osteoarthritis, such that osteoarthritis is prevented or delayed in its progression. The appropriate therapeutic composition can be determined based on screening assays described herein. [0199] As discussed, successful treatment of osteoarthritis can be brought about by techniques that serve to agonize target molecule expression or function, or alternatively, antagonize target molecule expression or function. These techniques include administration of modulators that include, but are not limited to, small organic or inorganic molecules; antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and Fab, F(ab')2 and Fab expression library fragments, scFV molecules, and epitope-binding fragments thereof); and peptides, phosphopeptides, or polypeptides. [0200] Further, antisense and ribozyme molecules that inhibit expression of the target gene can also be used to reduce the level of target gene expression, thus effectively reducing the level of target gene activity. Still further, triple helix molecules can be utilized in reducing the level of target gene activity. Antisense, ribozyme and triple helix molecules are discussed above. It is possible that the use of antisense, ribozyme, and/or triple helix molecules to reduce or inhibit mutant gene expression can also reduce or inhibit the transcription (triple helix) and/or translation (antisense, ribozyme) of mRNA produced by normal target gene alleles, such that the concentration of normal target gene product present can be lower than is necessary for a normal phenotype. In such cases, nucleic acid molecules that encode and express target gene polypeptides exhibiting normal target gene activity can be introduced into cells via gene therapy method. Alternatively, in instances in that the target gene encodes an extracellular polypeptide, it can be preferable to co-administer normal target gene polypeptide into the cell or tissue in order to maintain the requisite level of cellular or tissue target gene activity. [0201] Another method by which nucleic acid molecules may be utilized in treating or preventing osteoarthritis is use of aptamer molecules specific for target molecules. Aptamers are nucleic acid molecules having a tertiary structure which permits them to specifically bind to ligands (see, e.g., Osborne, et al, Curr. Opin. Chem. Biol.1(1): 5-9 (1997); and Patel, D. J, Curr. Opin. Chem. Biol. Jun; 1(1): 32-46 (1997)). [0202] Yet another method of utilizing nucleic acid molecules for osteoarthritis treatment is gene therapy, which can also be referred to as allele therapy. Provided herein is a gene therapy method for treating osteoarthritis in a subject, which comprises contacting one or more cells in the subject or from the subject with a nucleic acid having a first nucleotide sequence (e.g., the first nucleotide sequence is identical to or substantially identical to a nucleotide sequence of SEQ ID NO: 1-13 or other nucleotide sequence referenced in Table B). Genomic DNA in the subject comprises a second nucleotide sequence having one or more polymorphic variations associated with osteoarthritis (e.g., the second nucleotide sequence is identical to or substantially identical to a nucleotide sequence of SEQ ID NO: 1-13 or other nucleotide sequence referenced in Table B). The first and second nucleotide sequences typically are substantially identical to one another, and the first nucleotide sequence comprises fewer polymorphic variations associated with osteoarthritis than the second nucleotide sequence. The first nucleotide sequence may comprise a gene sequence that encodes a full-length polypeptide or a fragment thereof. The subject is often a human. Allele therapy methods often are utilized in conjunction with a method of first determining whether a subject has genomic DNA that includes polymorphic variants associated with osteoarthritis. [0203] In a certain embodiment, the method often comprises supplementing arthritis-associated ADAMTS2 polypeptide with a non-arthritis-associated ADAMTS2 polypeptide or fragment thereof, where the non-arthritis-associated form of ADAMTS2 contains an isoleucine at position 245 of SEQ ID NO: 44 having enzymatic activity. The arthritis-associated ADAMTS2 polypeptide sometimes contains a valine at position 245 of SEQ ID NO: 44 having an altered enzymatic activity varying from the non- arthritis-associated polypeptide. [0204] In an embodiment, provided is a method of increasing the synthesis of procollagen II comprising providing or administering to individuals in need of increasing levels of type II collagen the pharmaceutical or physiologically acceptable composition comprising active human ADAMTS2 protein or fragment thereof, where ADAMTS2 polypeptide fragments having activity are selected from amino acids 252-1211, 253-1211, 254-1211, 255-1211, 256-1211, 257-1211, 258-1211, 259-1211 or 260-1211 of SEQ ID NO: 44, where it is understood that the active form of ADAMTS2 does not contain the propeptide domain. [0205] In another embodiment, provided herein is a method of increasing the synthesis of procollagen II comprising providing or administering to individuals in need of increasing levels of type II collagen the pharmaceutical or physiologically acceptable composition comprising an enzyme or molecule capable of cleaving ADAMTS2 propeptide, e.g., a furin-type endopeptidase or N- ethylmaleimide described herein [02 6] In another allele therapy embodiment, provided herein is a method which comprises contacting one or more cells in the subject or from the subject with a polypeptide encoded by a nucleic acid having a first nucleotide sequence (e.g. , the first nucleotide sequence is identical to or substantially identical to the nucleotide sequence of SEQ ID NO: 1-13 or other nucleotide sequence referenced in Table B). Genomic DNA in the subject comprises a second nucleotide sequence having one or more polymorphic variations associated with osteoarthritis (e.g., the second nucleotide sequence is identical to or substantially identical to a nucleotide sequence of SEQ ID NO: 1-13 or other nucleotide sequence referenced in Table B). The first and second nucleotide sequences typically are substantially identical to one another, and the first nucleotide sequence comprises fewer polymorphic variations associated with osteoarthritis than the second nucleotide sequence. The first nucleotide sequence may comprise a gene sequence that encodes a full-length polypeptide or a fragment thereof. The subject is often a human. [02O7] For antibody-based therapies, antibodies can be generated that are both specific for target molecules and that reduce target molecule activity. Such antibodies may be administered in instances where antagonizing a target molecule function is appropriate for the treatment of osteoarthritis. [02O8] In circumstances where stimulating antibody production in an animal or a human subject by injection with a target molecule is harmful to the subject, it is possible to generate an immune response against the target molecule by use of anti-idiotypic antibodies (see, e.g., Herlyn, Ann. Med.;31(l): 66-78 (1999); and Bhattacharya-Chatterjee & Foon, Cancer Treat. Res.; 94: 51-68 (1998)). Introducing an anti-idiotypic antibody to a mammal or human subject often stimulates production of anti-anti-idiotypic antibodies, which typically are specific to the target molecule. Vaccines directed to osteoarthritis also may be generated in this fashion. [0209] In instances where the target molecule is intracellular and whole antibodies are used, internalizing antibodies may be preferred. Lipofectin or liposomes can be used to deliver the antibody or a fragment of the Fab region that binds to the target antigen into cells. Where fragments of the antibody are used, the smallest inhibitory fragment that binds to the target antigen is preferred. For example, peptides having an amino acid sequence corresponding to the Fv region of the antibody can be used. Alternatively, single chain neutralizing antibodies that bind to intracellular target antigens can also be administered. Such single chain antibodies can be administered, for example, by expressing nucleotide sequences encoding single-chain antibodies within the target cell population (see, e.g., Marasco et al, Proc. Natl. Acad. Sci. USA 90: 7889-7893 (1993)). [0210] Modulators can be administered to a patient at therapeutically effective doses to treat osteoarthritis. A therapeutically effective dose refers to an amount of the modulator sufficient to result in amelioration of symptoms of osteoarthritis. Toxicity and therapeutic efficacy of modulators can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50%> of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Modulators that exhibit large therapeutic indices are preferred. While modulators that exhibit toxic side effects can be used, care should be taken to design a delivery system that targets such molecules to the site of affected tissue in order to minimize potential damage to uninfected cells, thereby reducing side effects. [0211] Data obtained from cell culture assays and animal studies can be used in formulating a range of dosages for use in humans. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage can vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the methods described herein, the therapeutically effective dose can be estimated initially from cell culture assays. A dose can be formulated in animal models to achieve a circulating plasma concentration range that includes the IC50 (i.e., the concentration of the test compound that achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma can be measured, for example, by high performance liquid chromatography. [0212] Another example of effective dose determination for an individual is the ability to directly assay levels of "free" and "bound" compound in the serum of the test subject. Such assays may utilize antibody mimics and/or "biosensors" that have been created through molecular imprinting techniques. Molecules that modulate target molecule activity are used as a template, or "imprinting molecule", to spatially organize polymerizable monomers prior to their polymerization with catalytic reagents. The subsequent removal of the imprinted molecule leaves a polymer matrix which contains a repeated "negative image" of the compound and is able to selectively rebind the molecule under biological assay conditions. A detailed review of this technique can be seen in Ansell et al, Current Opinion in Biotechnology! 7: 89-94 (1996) and in Shea, Trends in Polymer Science 2: 166-173 (1994). Such "imprinted" affinity matrixes are amenable to ligand-binding assays, whereby the immobilized monoclonal antibody component is replaced by an appropriately imprinted matrix. An example of the use of such matrixes in this way can be seen in Vlatakis, et al, Nature 361: 645-647 (1993). Through the use of isotope-labeling, the "free" concentration of compound which modulates target molecule expression or activity readily can be monitored and used in calculations of IC50. Such "imprinted" affinity matrixes can also be designed to include fluorescent groups whose photon-emitting properties measurably change upon local and selective binding of target compound. These changes readily can be assayed in real time using appropriate fiberoptic devices, in turn allowing the dose in a test subject to be quickly optimized based on its individual IC50. An example of such a "biosensor" is discussed in Kriz et al, Analytical Chemistry 67: 2142-2144 (1995). [0213] The examples set forth below are intended to illustrate but not limit the invention.
Examples [0214] In the following studies a group of subjects was selected according to specific parameters relating to osteoarthritis. Nucleic acid samples obtained from individuals in the study group were subjected to genetic analysis, which identified associations between osteoarthritis and certain polymorphic variants in the following genes: PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, PELI2, LOXLl, CASPR4, GPR50 or APOL3 (herein referred to as "Targets"). The polymorphisms were genotyped again in two replication cohorts consisting of individuals selected for OA. In addition, SNPs proximal to the incident polymorphism in APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CASPR4 and APOL3 regions were identified and allelotyped in OA case and control pools. Methods are described for producing target polypeptides encoded by the nucleic acids of Table B in vitro or in vivo, which can be utilized in methods that screen test molecules for those that interact with target polypeptides. Test molecules identified as interactors with target polypeptides can be screened further as osteoarthritis therapeutics.
Example 1 Samples and Pooling Strategies
Sample Selection [0215] Blood samples were collected from individuals diagnosed with knee osteoarthritis, which were referred to as case samples. Also, blood samples were collected from individuals not diagnosed with knee osteoarthritis as gender and age-matched controls. A database was created that listed all phenotypic trait information gathered from individuals for each case and control sample. Genomic DNA was extracted from each of the blood samples for genetic analyses.
DNA Extraction from Blood Samples [0216] Six to ten milliliters of whole blood was transferred to a 50 ml tube containing 27 ml of red cell lysis solution (RCL). The tube was inverted until the contents were mixed. Each tube was incubated for 10 minutes at room temperature and inverted once during the incubation. The tubes were then centrifuged for 20 minutes at 3000 x g and the supernatant was carefully poured off. 100-200 μl of residual liquid was left in the tube and was pipetted repeatedly to resuspend the pellet in the residual supernatant. White cell lysis solution (WCL) was added to the tube and pipetted repeatedly until completely mixed. While no incubation was normally required, the solution was incubated at 37°C or room temperature if cell clumps were visible after mixing until the solution was homogeneous. 2 ml of protein precipitation was added to the cell lysate. The mixtures were vortexed vigorously at high speed for 20 sec to mix the protein precipitation solution uniformly with the cell lysate, and then centrifuged for 10 minutes at 3000 x g. The supernatant containing the DNA was then poured into a clean 15 ml tube, which contained 7 ml of 100^o isopropanol. The samples were mixed by inverting the tubes gently until white threads of DNA were visible. Samples were centrifuged for 3 minutes at 2000 x g and the DNA was visible as a small white pellet. The supernatant was decanted and 5 ml of 70% ethanol was added to each tube. Each tube was inverted several times to wash the DNA pellet, and then centrifuged for 1 minute at 2000 x g. The ethanol was decanted and each tube was drained on clean absorbent paper. The DNA was dried in the tube by inversion for 10 minutes, and then 1000 μl of IX TE was added. The size of each sample was estimated, and less TE buffer was added during the following DNA hydration step if the sample was smaller. The DNA was allowed to rehydrate overnight at room temperature, and DNA samples were stored at 2-8°C. [0217] DNA was quantified by placing samples on a hematology mixer for at least 1 hour. DNA was serially diluted (typically 1:80, 1 : 160, 1 :320, and 1 :640 dilutions) so that it would be within the measurable range of standards. 125 μl of diluted DNA was transferred to a clear U-bottom microtitre plate, and 125 μl of IX TE buffer was transferred into each well using a multichannel pipette. The DNA and IX TE were mixed by repeated pipetting at least 15 times, and then the plates were sealed. 50 μl of diluted DNA was added to wells A5-H12 of a black flat bottom microtitre plate. Standards were inverted six times to mix them, and then 50 μl of IX TE buffer was pipetted into well Al, 1000 ng/ml of standard was pipetted into well A2, 500 ng/ml of standard was pipetted into well A3, and 250 ng/ml of standard was pipetted into well A4. PicoGreen (Molecular Probes, Eugene, Oregon) was thawed and freshly diluted 1:200 according to the number of plates that were being measured. PicoGreen was vortexed and then 50μl was pipetted into all wells of the black plate with the diluted DNA. DNA and PicoGreen were mixed by pipetting repeatedly at least 10 times with the multichannel pipette. The plate was placed into a Fluoroskan Ascent Machine (microplate fluorometer produced by Labsystems) and the samples were allowed to incubate for 3 minutes before the machine was run using filter pairs 485 nm excitation and 538 nm emission wavelengths. Samples having measured DNA concentrations of greater than 450 ng/μl were re-measured for conformation. Samples having measured DNA concentrations of 20 ng/μl or less were re-measured for confirmation.
Pooling Strategies - Discovery Cohort [0218] Samples were derived from the Nottingham knee OA family study (UK) where index cases were identified through a knee replacement registry. Siblings were approached and assessed with knee x-rays and assigned status as affected or unaffected. In all 1,157 individuals were available. In order to create same-sex pools of appropriate sizes, 335 unrelated female individuals with OA from the Nottingham OA sample were selected for the case pool. The control pool was made up of unrelated female individuals from the St. Thomas twin study (England) with normal knee x-rays and without other indications of OA, regardless of anatomical location, as well as lacking family history of OA. The St. Thomas twin study consists of Caucasian, female participants from the St. Thomas' Hospital, London, adult-twin registry, which is a voluntary registry of >4,000 twin pairs ranging from 18 to 76 years of age. The female case samples and female control samples are described further in Table 1 below. [0219] A select set of samples from each group were utilized to generate pools, and one pool was created for each group. Each individual sample in a pool was represented by an equal amount of genomic DNA. For example, where 25 ng of genomic DNA was utilized in each PCR reaction and there were 200 individuals in each pool, each individual would provide 125 pg of genomic DNA. Inclusion or exclusion of samples for a pool was based upon the following criteria: the sample was derived from an individual characterized as Caucasian; the sample was derived from an individual of British paternal and maternal descent; case samples were derived from individuals diagnosed with specific knee osteoarthritis (OA) and were recruited from an OA knee replacement clinic. Control samples were derived from individuals free of OA, family history of OA, and rheumatoid arthritis. Also, sufficient genomic DNA was extracted from each blood sample for all allelotyping and genotyping reactions performed during the study. Phenotype information from each individual was collected and included age of the individual, gender, family history of OA, general medical information (e.g., height, weight, thyroid disease, diabetes, psoriasis, hysterectomy), joint history (previous and current symptoms, joint-related operations, age at onset of symptoms, date of primary diagnosis, age of individual as of primary diagnosis and order of involvement), and knee-related findings (crepitus, restricted passive movement, bony swelling/deformity). Additional knee information included knee history, current symptoms, any major knee injury, menisectomy, knee replacement surgery, age of surgery, and treatment history (including hormone replace therapy (HRT)). Samples that met these criteria were added to appropriate pools based on disease status. [0220] The selection process yielded the pools set forth in Table 1, which were used in the studies that follow:
TABLE 1
Figure imgf000067_0001
Ex ample 2 Association of Polymorphic Variants with Osteoarthritis [0221] A whole-genome screen was performed to identify particular SNPs associated with occurrence of osteoarthritis. As described in Example 1, two sets of samples were utilized, which included samples from female individuals having knee osteoarthritis (osteoarthritis cases), and samples from female individuals not having knee osteoarthritis (female controls). The initial screen of each pool was performed in an allelotyping study, in which certain samples in each group were pooled. By pooling DNA from each group, an allele frequency for each SNP in each group was calculated. These allele frequencies were then compared to one another. Particular SNPs were considered as being associated with osteoarthritis when allele frequency differences calculated between case and control pools were statistically significant. SNP disease association results obtained from the allelotyping study were then validated by genotyping each associated SNP across all samples from each pool. The results of the genotyping then were analyzed, allele frequencies for each group were calculated from the individual genotyping results, and a p-value was calculated to determine whether the case and control groups had statistically significant differences in allele frequencies for a particular SNP. When the genotyping results agreed with the original allelotyping results, the SNP disease association was considered validated at the genetic level.
SNP Panel Used for Genetic Analyses [0222] A whole-genome SNP screen began with an initial screen of approximately 25,000 SNPs over each set of disease and control samples using a pooling approach. The pools studied in the screen are described in Example 1. The SNPs analyzed in this study were part of a set of 25,488 SNPs confirmed as being statistically polymorphic as each is characterized as having a minor allele frequency of greater than 10%. The SNPs in the set reside in genes or in close proximity to genes, and many reside in gene exons. Specifically, SNPs in the set are located in exons, introns, and within 5,000 base- pairs upstream of a transcription start site of a gene. In addition, SNPs were selected according to the following criteria: they are located in ESTs; they are located in Locuslink or Ensembl genes; and they are located in Genomatix promoter predictions. SNPs in the set were also selected on the basis of even spacing across the genome, as depicted in Table 2. [0223] A case-control study design using a whole genome association strategy involving approximately 28,000 single nucleotide polymorphisms (SNPs) was employed. Approximately 25,000 SNPs were evenly spaced in gene-based regions of the human genome with a median inter-marker distance of about 40,000 base pairs. Additionally, approximately 3,000 SNPs causing amino acid substitutions in genes described in the literature as candidates for various diseases were used. The case- control study samples were of female Caucasian origin (British paternal and maternal descent) 670 individuals were equally distributed in two groups: female confrols and female cases. The whole genome association approach was first conducted on 2 DNA pools representing the 2 groups. Significant markers were confirmed by individual genotyping.
TABLE 2 General Statistics Spacing Statistics Total # of SNPs 25,488 Median 37,058 bp # of Exonic SNPs >4,335 (17%) Minimum* 1,000 bp # SNPs with refSNP ID 20,776 (81%) Maximum* 3,000,000 bp Gene Coverage >10,000 Mean 122,412 bp Chromosome Coverage All Std Deviation 373,325 bp ^Excludes outliers
Allelotyping and Genotyping Results [0224] The genetic studies summarized above and described in more detail below identified allelic variants associated with osteoarthritis, which are summarized in Table B.
Assay for Verifying. Allelotyping. and Genotyping SNPs [0225] A MassARRAY™ system (Sequenom, Inc.) was utilized to perform SNP genotyping in a high-throughput fashion. This genotyping platform was complemented by a homogeneous, single-tube assay method (hME™ or homogeneous MassEXTEND™ (Sequenom, Inc.)) in which two genotyping primers anneal to and amplify a genomic target surrounding a polymorphic site of interest. A third primer (the MassEXTEND™ primer), which is complementary to the amplified target up to but not inclu-ding the polymorphism, was then enzymatically extended one or a few bases through the polymorphic site and then terminated. [0226] For each polymorphism, SpectroDESIGNER™ software (Sequenom, Inc.) was used to generate a set of PCR primers and a MassEXTEND™ primer which where used to genotype the polymorphism. Other primer design software could be used or one of ordinary skill in the art could manually design primers based on his or her knowledge of the relevant factors and considerations in designing such primers. Table 3 shows PCR primers and Table 4 shows extension primers used for analyzing polymorphisms. The initial PCR amplification reaction was performed in a 5 μl total volume containing IX PCR buffer with 1.5 mM MgCl2 (Qiagen), 200 μM each of dATP, dGTP, dCTP, dTTP (Gibco-BRL), 2.5 ng of genomic DNA, 0.1 units of HotStar DNA polymerase (Qiagen), and 200 nM each of forward and reverse PCR primers specific for the polymorphic region of interest.
TABLE 3: PCR Primers
Figure imgf000069_0001
[0227] Samples were incubated at 95°C for 15 minutes, followed by 45 cycles of 95°C for 20 seconds, 56°C for 30 seconds, and 72°C for 1 minute, finishing with a 3 minute final extension at 72°C. Following amplification, shrimp alkaline phosphatase (SAP) (0.3 units in a 2 μl volume) (Amersham Pharmacia) was added to each reaction (total reaction volume was 7 μl) to remove any residual dNTPs that were not consumed in the PCR step. Samples were incubated for 20 minutes at 37°C, followed by 5 minutes at 85°C to denature the SAP. [0228] Once the SAP reaction was complete, a primer extension reaction was initiated by adding a polymorphism-specific MassEXTEND™ primer cocktail to each sample. Each MassEXTEND™ cocktail included a specific combination of dideoxynucleotides (ddNTPs) and deoxynucleotides (dNTPs) used to distinguish polymorphic alleles from one another. Methods for verifying, allelotyping and genotyping SNPs are disclosed, for example, in U.S. Pat. No. 6,258,538, the content of which is hereby incorporated by reference. In Table 4, ddNTPs are shown and the fourth nucleotide not shown is the dNTP.
TABLE 4: Extension Primers
Figure imgf000069_0002
Figure imgf000070_0001
[0229] The MassEXTEND™ reaction was performed in a total volume of 9 μl, with the addition of IX ThermoSequenase buffer, 0.576 units of ThermoSequenase (Amersham Pharmacia), 600 nM MassEXTEND™ primer, 2 mM of ddATP and/or ddCTP and/or ddGTP and/or ddTTP, and 2 mM of dATP or dCTP or dGTP or dTTP. The deoxy nucleotide (dNTP) used in the assay normally was complementary to the nucleotide at the polymorphic site in the amplicon. Samples were incubated at 94°C for 2 minutes, followed by 55 cycles of 5 seconds at 94°C, 5 seconds at 52°C, and 5 seconds at 72°C. [0230] Following incubation, samples were desalted by adding 16 μl of water (total reaction volume was 25 μl), 3 mg of SpectroCLEAN™ sample cleaning beads (Sequenom, Inc.) and allowed to incubate for 3 minutes with rotation. Samples were then robotically dispensed using a piezoelectric dispensing device (SpectroJET™ (Sequenom, Inc.)) onto either 96-spot or 384-spot silicon chips containing a matrix that crystallized each sample (SpectroCHJP™ (Sequenom, Inc.)). Subsequently, MALDI-TOF mass spectrometry (Biflex and Autoflex MALDI-TOF mass spectrometers (Bruker Daltonics) can be used) and SpectroTYPER RT™ software (Sequenom, Inc.) were used to analyze and interpret the SNP genotype for each sample.
Genetic Analysis [0231] Minor allelic frequencies for the polymoφhisms set forth in Table B were verified as being 10%) or greater using the extension assay described above in a group of samples isolated from 92 individuals originating from the state of Utah in the United States, Venezuela and France (Coriell cell repositories). [0232] Genotyping results are shown for female pools in Table 5. In Table 5, "AF" refers to allelic frequency; and "F case" and "F control" refer to female case and female control groups, respectively.
TABLE 5: Genotyping Results
Figure imgf000070_0002
Figure imgf000071_0001
[0233] All of the single marker alleles set forth in Table B were considered validated, since the genotyping data agreed with the allelotyping data and each SNP significantly associated with osteoarthritis. Particularly significant associations with osteoarthritis are indicated by a calculated p- value of less than 0.05 for genotype results.
Example 3 Association of Polymorphic Variants with Osteoarthritis in Replication Cohorts [0234] The single marker polymorphisms set forth in Table B were genotyped again in two replication cohorts consisting of individuals selected for OA.
Sample Selection and Pooling Strategies - Replication Sample 1 [0235] A second case control sample (replication sample #1) was created by using 100 Caucasian female cases from Chingford, UK, and 148 unrelated female cases from the St. Thomas twin study. Cases were defined as having Kellgren-Lawrence (KL) scores of at least 2 in at least one knee x-ray. In addition, 199 male knee replacement cases from Nottingham were included. (For a cohort description, see the Nottingham description provided in Example 1). The control pool was made up of unrelated female individuals from the St. Thomas twin study (England) with normal knee x-rays and without other indications of OA, regardless of anatomical location, as well as lacking family history of OA. The St. Thomas twin study consists of Caucasian, female participants from the St. Thomas' Hospital, London, adult-twin registry, which is a voluntary registry of >4,000 twin pairs ranging from 18 to 76 years of age. The replication sample 1 cohort was used to replicate the initial results. Table 6 below summarizes the selected phenotype data collected from the case and control individuals.
TABLE 6
Figure imgf000071_0002
Figure imgf000072_0001
* 0: normal, 1: doubtful, 2: definite osteophyte (bony protuberance), 3: joint space narrowing (with or without osteophyte), 4: joint deformity
Sample Selection and Pooling Strategies - Replication Sample 2 [0236] A third case control sample (replication sample #2) was created by using individuals with symptoms of OA from Newfoundland, Canada. These individuals were recruited and examined by rheumatologists. Affected joints were x-rayed and a final diagnosis of definite or probable OA was made according to American College of Rheumatology criteria by a single rheumatologist to avoid any inter-examiner diagnosis variability. Controls were recruited from volunteers without any symptoms from the musculoskeletal system based on a normal joint exam performed by a rheumatologist. Only cases with a diagnosis of definite OA were included in the study. Only individuals of Caucasian origin were included. The cases consisted of 228 individuals with definite knee OA, 106 individuals with definite hip OA, and 74 individuals with hip OA.
TABLE 7
Figure imgf000072_0002
Assay for Verifying. Allelotyping, and Genotyping SNPs [0237] Genotyping of the replication cohorts described in Tables 6 and 7 was performed using the same methods used for the original genotyping, as described herein. A MassARRAY™ system
7 (Sequenom, Inc.) was utilized to perform SNP genotyping in a high-throughput fashion. This genotyping platform was complemented by a homogeneous, single-tube assay method (hME™ or homogeneous MassEXTEND™ (Sequenom, Inc.)) in which two genotyping primers anneal to and amplify a genomic target surrounding a polymorphic site of interest. A third primer (the MassEXTEND™ primer), which is complementary to the amplified target up to but not including the polymorphism, was then enzymatically extended one or a few bases through the polymorphic site and then terminated. [0238] For each polymorphism, SpectroDESIGNER™ software (Sequenom, Inc.) was used to generate a set of PCR primers and a MassEXTEND™ primer which where used to genotype the polymorphism. Other primer design software could be used or one of ordinary skill in the art could manually design primers based on his or her knowledge of the relevant factors and considerations in designing such primers. Table 3 shows PCR primers and Table 4 shows extension probes used for analyzing (e.g., genotyping) polymorphisms in the replication cohorts. The initial PCR amplification reaction was performed in a 5 μl total volume containing IX PCR buffer with 1.5 mM MgCl2 (Qiagen), 200 μM each of dATP, dGTP, dCTP, dTTP (Gibco-BRL), 2.5 ng of genomic DNA, 0.1 units of HotStar DNA polymerase (Qiagen), and 200 nM each of forward and reverse PCR primers specific for the polymorphic region of interest. [0239] Samples were incubated at 95°C for 15 minutes, followed by 45 cycles of 95°C for 20 seconds, 56°C for 30 seconds, and 72°C for 1 minute, finishing with a 3 minute final extension at 72°C. Following amplification, shrimp alkaline phosphatase (SAP) (0.3 units in a 2 μl volume) (Amersham Pharmacia) was added to each reaction (total reaction volume was 7 μl) to remove any residual dNTPs that were not consumed in the PCR step. Samples were incubated for 20 minutes at 37°C, followed by 5 minutes at 85°C to denature the SAP. [0240] Once the SAP reaction was complete, a primer extension reaction was initiated by adding a polymorphism-specific MassEXTEND™ primer cocktail to each sample. Each MassEXTEND™ cocktail included a specific combination of dideoxynucleotides (ddNTPs) and deoxynucleotides (dNTPs) used to distinguish polymorphic alleles from one another. Methods for verifying, allelotyping and genotyping SNPs are disclosed, for example, in U.S. Pat. No. 6,258,538, the content of which is hereby incorporated by reference. In Table 1, ddNTPs are shown and the fourth nucleotide not shown is the dNTP. [0241] The MassEXTEND™ reaction was performed in a total volume of 9 μl, with the addition of
IX ThermoSequenase buffer, 0.576 units of ThermoSequenase (Amersham Pharmacia), 600 nM
MassEXTEND™ primer, 2 mM of ddATP and/or ddCTP and/or ddGTP and/or ddTTP, and 2 mM of dATP or dCTP or dGTP or dTTP. The deoxy nucleotide (dNTP) used in the assay normally was complementary to the nucleotide at the polymorphic site in the amplicon. Samples were incubated at
94°C for 2 minutes, followed by 55 cycles of 5 seconds at 94°C, 5 seconds at 52°C, and 5 seconds at 72°C. [0242] Following incubation, samples were desalted by adding 16 μl of water (total reaction volume was 25 μl), 3 mg of SpectroCLEAN™ sample cleaning beads (Sequenom, Inc.) and allowed to incubate for 3 minutes with rotation. Samples were then robotically dispensed using a piezoelectric dispensing device (SpectroJET™ (Sequenom, Inc.)) onto either 96-spot or 384-spot silicon chips containing a matrix that crystallized each sample (SpectroCFHP™ (Sequenom, Inc.)). Subsequently, MALDI-TOF mass spectrometry (Biflex and Autoflex MALDI-TOF mass spectrometers (Bruker Daltonics) can be used) and SpecfroTYPER RT™ software (Sequenom, Inc.) were used to analyze and interpret the SNP genotype for each sample.
Genetic Analysis [0243] Genotyping results for replication cohorts #1 and #2 are provided in Tables 8 and 9, respectively.
TABLE 8
Figure imgf000074_0001
TABLE 9
Figure imgf000074_0002
Figure imgf000075_0001
[0244] To combine the evidence for association from multiple sample collections, a meta-analysis procedure was employed. The allele frequencies were compared between cases and controls within the discovery sample, as well as within the replication cohort #1 using the DerSimian-Laird approach (DerSimonian, R. and N. Laird. 1986. Meta-analysis in clinical trials. Control Clin Trials 7: 177-188.) [0245] The absence of a statistically significant association in one or more of the replication cohorts should not be interpreted as minimizing the value of the original finding. There are many reasons why a biologically derived association identified in a sample from one population would not replicate in a sample from another population. The most important reason is differences in population history. Due to bottlenecks and founder effects, there may be common disease predisposing alleles present in one population that are relatively rare in another, leading to a lack of association in the candidate region. Also, because common diseases such as arthritis-related disorders are the result of susceptibilities in many genes and many environmental risk factors, differences in population-specific genetic and environmental backgrounds could mask the effects of a biologically relevant allele. For these and other reasons, statistically strong results in the original, discovery sample that did not replicate in one or more of the replication samples may be further evaluated in additional replication cohorts and experimental systems. [0246] APOB, IL1RL2, WASPIP, BVES, LOXLl and CASPR4 regions were analyzed further, as shown in the examples below. PADI2, described above, is a peptidyl arginine deiminase enzyme, type II, that converts arginine residues within proteins to citrulline residues. This gene is one of four known PADI genes that encode enzymes that catalyze conversion of arginine to citrulline in proteins. Individuals with rheumatoid arthritis (RA) frequently have autoantibodies to citrullinated peptides, suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes in RA (van Venrooij et al., Arthritis Res.;2(4):249-51. Epub 2000 May 24). [0247] Pellino homo log 2 from Drosophila (PELI2) is a a member of the Pellino gene family, which are involved in Toll-like signalling pathways. Pellino-2 associates with the pelle-like kinase/TL- lR-associated kinase protein to couple the pelle-like kinase/IL-lR-associated kinase protein to IL-1- or LPS-dependent signaling. PELI2 may act as a downstream effector of" interleukin receptor signaling and may play a role in inflammation-mediated Osteoarthritis. Pathway members downstream of PELI2 may be targetable {e.g., interleukin receptors). [0248] G protein-coupled receptor 50 (GPR50) is a member of the G protein-coupled receptor family. GPR50 has significant homology to melatonin receptors and was isolated by PCR of human genomic DNA with degenerate primers based on conserved regions of melatonin receptors.
Example 4 APOB Proximal SNPs [0249] It has been discovered that rs 1367117 is associated with occurrence of osteoarthritis in subjects. The polymorphic variant lies within the APOB gene and codes for a I98T amino acid change. The guanine allele of SNP rsl367117 is associated with osteoarthritis (see Table 5) and codes for a threonine at position 98 (see, for example, amino acid sequence in SEQ ID NO: 38). [0250] Apolipoprotein B (ApoB) is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL,). ApoB binds to sulfated proteoglycans, especially chondroitin and dermatan sulfate, that are components of cartilage (Camejo et. al., Atherosclerosis. 1998 Aug;139(2):205-22). This may contribute to inflammation/joint damage by lipoprotein oxidation products. In addition, increased levels of ApoB is seen as a risk factor for osteonecrosis (Miyanishi et. al., Ann Rheum Dis. 1999 Aug;58(8):514-6) . Lipoprotein deposition has been noted in inflammatory (rheumatoid) arthritis and may play a role in inflammation mediated osteoarthritis. ApoB function can be modulated by addition of an antibody or a decoy receptor for ApoB. Examples of antibodies and small molecules that specifically interact withApoB are described in U.S. Patent Nos. 6,107,045; 6,309,844; 5,330,910; and 6,369,075. [0251] One hundred twenty-two additional allelic variants proximal to rs 1367117 were identified and subsequently allelotyped in osteoarthritis case and control sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 10. The chromosome positions provided in column four of Table 10 are based on Genome "Build 34" of NCBFs GenBan .
TABLE 10
Figure imgf000076_0001
Figure imgf000077_0001
Figure imgf000078_0001
Figure imgf000079_0001
Assay for Verifying and Allelotyping SNPs [0252] The methods used to verify and allelotype the 1 2 proximal SNPs of Table 10 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 11 and Table 12, respectively.
TABLE 11
Figure imgf000079_0002
Figure imgf000080_0001
Figure imgf000081_0001
TABLE 12
Figure imgf000081_0002
Figure imgf000082_0001
Figure imgf000083_0001
Figure imgf000084_0001
Genetic Analysis [0253] Allelotyping results from the discovery cohort are shown for cases and controls in Table 13. The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and confrol pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rsl318006 has the following case and control allele frequencies: case Al (C) = 0.494; case A2 (T) = 0.506; control Al (C) = 0.460; and control A2 (T) = 0.540, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays.
TABLE 13
Figure imgf000084_0002
Figure imgf000085_0001
Figure imgf000086_0001
[0254] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure IA for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure 1 A can be determined by consulting Table 13. For example, the left-most X on the left graph is at position 21188688. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0255] To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of
Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p- values that were less than 10'8 were truncated at that value. [0256] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
Example 5 IL1RL2 Proximal SNPs [0257] It has been discovered that rsl024791, which lies within the IL1RL2 gene, is associated with occurrence of osteoarthritis in subjects. Interleukin-1 receptor-like 2 is a member of the interleukin 1 receptor family. IL1RL2 inhibits IL-1 activity and contains immmunoglobulin domains. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (ILIRLI), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2ql2. IL1RL2 may mediate inflammatory responses that can contribute to the development of OA. IL1RL2 biological activity can be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant IL1RL2 protein or functional fragment thereof. [0258] One hundred forty additional allelic variants proximal to rs 1024791 were identified and subsequently allelotyped in osteoarthritis case and control sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 14. The chromosome positions provided in column four of Table 14 are based on Genome "Build 34" of NCBI's GenBank.
TABLE 14
Figure imgf000087_0001
Figure imgf000088_0001
Figure imgf000089_0001
Figure imgf000090_0001
Assay for Verifying and Allelotyping SNPs [0259] The methods used to verify and allelotype the 140 proximal SNPs of Table 14 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 15 and Table 16, respectively.
TABLE 15
Figure imgf000090_0002
Figure imgf000091_0001
Figure imgf000092_0001
Figure imgf000093_0001
TA-BLE 16
Figure imgf000093_0002
Figure imgf000094_0001
Figure imgf000095_0001
Figure imgf000096_0001
Genetic Analysis [0260] Allelotyping results from the discovery cohort are shown for cases and controls in Table 17. The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rs3917304 has the following case and control allele frequencies: case Al (G) = 0.431; case A2 (T) = 0.569; confrol Al (G) = 0.450; and control A2 (T) = 0.550, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays.
TABLE 17
Figure imgf000096_0002
Figure imgf000097_0001
Figure imgf000098_0001
[0261] The IL1RL2 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 15 and 16. The replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 18 and 19, respectively.
TABLE 18
Figure imgf000099_0001
Figure imgf000100_0001
Figure imgf000101_0001
TABLE 19
Figure imgf000101_0002
Figure imgf000102_0001
Figure imgf000103_0001
[0262] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure IB for the discovery cohort. The position of each SNP on ttie chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base lO) of the p- value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure IB can be determined by consulting Table 17. For example, the left-most X on the left graph is at position 102409525. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0263] To aid the inteφretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black: line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10"8 were truncated at that value. [0264] Finally, the exons and introns of the genes in the covered region are plotted below each- graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' &nd of each gene to show the direction of transcription.
Example 6 ILIRLI Region Proximal SNPs [0265] It has been discovered that SNP rs 1041973 in Interleukin 1 receptor-like 1 isoform 1 (ILIRLI) is associated with occurrence of osteoarthritis in subjects. Interleukin 1 receptor-like 1 isoform 1 is a member of the interleukin 1 receptor family with no known ligand (orphan receptor). ILIRLI exists in both a soluble and transmembrane form, suggesting that it may have ligand or liga_nd scavenging activity. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptoir-like 2 (IL1RL2), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster. [0266] Ninety-one additional allelic variants proximal to rs 1041973 were identified and subsequently allelotyped in osteoarthritis case and control sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 20. The chromosome positions provided in column four of Table 20 are based on Genome "Build 34" of NCBI's GenBank.
TABLE 20
Figure imgf000104_0001
Figure imgf000105_0001
Figure imgf000106_0001
Assay for Verifying and Allelotyping SNPs [0267] The methods used to verify and allelotype the 91 proximal SNPs of Table 20 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 21 and Table 22, respectively.
TABLE 21
Figure imgf000106_0002
Figure imgf000107_0001
Figure imgf000108_0001
TABLE 22
Figure imgf000108_0002
Figure imgf000109_0001
Figure imgf000110_0001
Genetic Analysis [0268] Allelotyping results from the discovery cohort are shown for cases and controls in Table 23. The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rs951774 has the following case and confrol allele frequencies: case Al (A) = 0.24; case A2 (C) = 0.76; control Al (A) = 0.20; and control A2 (C) = 0.80, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays. TABLE 23
Figure imgf000111_0001
Figure imgf000112_0001
[0269] The ILIRLI proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 21 and 22. The replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 24 and 25, respectively.
TABLE 24
Figure imgf000112_0002
Figure imgf000113_0001
Figure imgf000114_0001
TABLE 25
Figure imgf000114_0002
Figure imgf000115_0001
[0270] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure IC for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNTP designated by an X or other symbol on the graphs in Figure IC can be determined by consulting Table 23. For example, the left-most X on the left graph is at position 102527857. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0271] To aid the inteφretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10"8 were truncated at that value. [0272] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
Example 7 WASPIP Region Proximal SNPs [0273] It has been discovered that rsl465621 in the untranslated region (UTR) of the WASPIP gene is associated with occurrence of osteoarthritis in subjects. This gene encodes a protein that plays a role in actin cytoskeleton organization. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Alternative transcript variants exist for this gene. Biological activity of WASPIP or a pathway member downsfream of WASPIP (e.g., IL-2) can be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant WASPIP or downstream pathway member protein or functional fragment thereof. [0274] Sixty-one additional allelic variants proximal to rsl465621 were identified and subsequently allelotyped in osteoarthritis case and confrol sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 26. The chromosome positions provided in column four of Table 26 are based on Genome "Build 34" of NCBI's GenBank. TABLE 26
Figure imgf000117_0001
Figure imgf000118_0001
Assay for Verifying and Allelotyping SNPs [0275] The methods used to verify and allelotype the 61 proximal SNPs of Table 26 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 27 and Table 28, respectively.
TABLE 27
Figure imgf000118_0002
Figure imgf000119_0001
TABLE 28
Figure imgf000119_0002
Figure imgf000120_0001
ll8
Figure imgf000121_0001
Genetic Analysis [0276] Allelotyping results from the discovery cohort are shown for cases and controls in Table 29.
The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency. The allele frequency for the A-1 allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rsl971763 has the following case and control allele frequencies: case Al (C) = 0.456; case A2 (T) = 0.544; control Al (C) = 0.444; and confrol A2 (T) = 0.556, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays.
TABLE 29
Figure imgf000121_0002
Figure imgf000122_0001
[0277] The WASPIP proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 27 and 28. The replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 30 and 31, respectively.
TABLE 30
Figure imgf000122_0002
Figure imgf000123_0001
TABLE 31
Figure imgf000123_0002
Figure imgf000124_0001
[0278] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure ID for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure ID can be determined by consulting Table 29. For example, the left-most X on the left graph is at position 175603909. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0279] To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01 , to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p- values that were less than 10"s were truncated at that value. [0280] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
Example 8 ADAMTS2 Region Proximal SNPs [0281] It has been discovered that SNP rs398829
Figure imgf000125_0001
is associated with occurrence of osteoarthritis in subjects. This gene encodes a disintegrin and metalloproteiixase with thrombospondin motifs-2 (ADAMTS2), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. ADAMT '-2 is involved in coUagens 1, 2 and 5 N-terminal processing, (type II collagen is the major form in cartilage). Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connectiv -tissue disorder that causes loose joints and fragile skin. Mild loss of function may exacerbate physical joint damage leading to a predisposition to OA and incorrectly processed collagen can act dominantly "to inhibit self assembly of fibrils. Alternative splicing of the gene generates 2 transcript variants. The short transcript encodes a protein, which has no significant procollagen N-peptidase activity. [0282] Two hundred-nine additional allelic variants proximal to rs3988_29 were identified and subsequently allelotyped in osteoarthritis case and control sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 32. The chromosome positions provided in column four of Table 32 are based on Genome "Build 34" of NCBI's GenBank.
TABLE 32
Figure imgf000125_0002
Figure imgf000126_0001
Figure imgf000127_0001
Figure imgf000128_0001
Figure imgf000129_0001
Figure imgf000130_0001
Assay for Verifying and Allelotyping SNPs [0283] The methods used to verify and allelotype the 209 proximal SNTPs of Table 32 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 33 and Table 34, respectively.
TABLE 33
Figure imgf000130_0002
Figure imgf000131_0001
Figure imgf000132_0001
Figure imgf000133_0001
Figure imgf000134_0001
TABLE 34
Figure imgf000134_0002
Figure imgf000135_0001
Figure imgf000136_0001
Figure imgf000137_0001
Figure imgf000138_0001
Genetic Analysis [0284] Allelotyping results from the discovery cohort are shown for cases and controls in Table 35. The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rs2278221 has the following case and control allele frequencies: case Al (C) = 0.36; case A2 (T) = 0.64; control Al (C) = 0.37; and confrol A2 (T) = 0.63, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays. TABLE 35
Figure imgf000139_0001
Figure imgf000140_0001
Figure imgf000141_0001
Figure imgf000142_0001
[0285] The ADAMTS2 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 33 and 34. The replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 36 and 37, respectively.
TABLE 36
Figure imgf000142_0002
Figure imgf000143_0001
Figure imgf000144_0001
Figure imgf000145_0001
TABLE 37
Figure imgf000146_0001
Figure imgf000147_0001
Figure imgf000148_0001
Figure imgf000149_0001
[0286] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure IE for the discovery cohort. The position of* each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure IE can be determined by consulting Table 35. For example, the left-most X on the left graph is at position 178695460. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0287] To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.O1. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (WAS. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical -Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.O1, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10"8 were truncated at that value. [0288] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
Example 9 BVES Proximal SNPs [0289] It was discovered that rs 1018810, an infronic SNP in the BVES gene, is associated with occurrence of osteoarthritis in subjects. BVES was identified as a blood vessel epicardial substance. Sequence analysis predicted 3 transmembrane helices with an extracellular C terminus. Northern blot analysis revealed that expression of an approximately 5.5-kb BVES transcript is restricted to skeletal muscle and adult and fetal heart. BVES is highly expressed in osteoarthritic cartilage according to EST database analysis, and may play a role in chondrocyte and/or bone cell development. BVES biological activity may be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant BVES protein or functional fragment thereof. [0290] One hundred fifty-four additional allelic variants proximal to rs 1018810 were identified and subsequently allelotyped in osteoarthritis case and confrol sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 38. The chromosome positions provided in column four of Table 38 are based on Genome "Build 34" of NCBI's GenBank.
TABLE 38
Figure imgf000150_0001
Figure imgf000151_0001
Figure imgf000152_0001
Assay for Verifying and Allelotyping SNPs [0291] The methods used to verify and allelotype the 1 4 proximal SNPs of Table 38 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 39 and Table 40, respectively.
TABLE 39
Figure imgf000153_0002
Figure imgf000154_0001
Figure imgf000155_0001
Figure imgf000156_0001
TABLE 40
Figure imgf000156_0002
Figure imgf000157_0001
Figure imgf000158_0001
Figure imgf000159_0001
Figure imgf000160_0001
Genetic Analysis [0292] Allelotyping results from the discovery cohort are shown for cases and confrols in Table 41.
The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rsl474555 has the following case and control allele frequencies: case Al (C) = 0.64; case A2 (T) = 0.36; confrol Al (C) = 0.70; and control A2 (T) = 0.30, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays.
TABLE 41
Figure imgf000160_0002
Figure imgf000161_0001
Figure imgf000162_0001
[0293] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure IF for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the confrol group. The minor allele frequency of the confrol group for each SNP designated by an X or other symbol on the graphs in Figure IF can be determined by consulting Table 41. For example, the left-most X on the left graph is at position 105557091. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0294] To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10"8 were truncated at that value. [0295] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
Example 10 TM7SF3 Region Proximal SNPs [0296] It has been discovered that SNP rsl484086 in TM7SF3 is associated with occurrence of osteoarthritis in subjects. TM7SF3 is an orphan receptor and is a member of the superfamily of 7- transmembrane domain proteins, one of the largest superfamilies of cell surface proteins. Members of this family include receptors for a variety of ligands, such as peptides, hormones, and ions, and for external sensory stimuli, such as odorants and light. Many 7-transmembrane molecules are able to recruit small G proteins, suggesting that they can transduce external signals to the cytoplasm. [0297] Thirty-seven additional allelic variants proximal to rs 1484086 were identified and subsequently allelotyped in osteoarthritis case and control sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 42. The chromosome positions provided in column four of Table 42 are based on Genome "Build 34" of NCBI's GenBank. TABLE 42
Figure imgf000164_0001
Assay for Verifying and Allelotyping SNPs [0298] The methods used to verify and allelotype the 37 proximal SNPs of Table 42 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 43 and Table 44, respectively. TABLE 43
Figure imgf000165_0001
TABLE 44
Figure imgf000165_0002
Figure imgf000166_0001
Genetic Analysis [0299] Allelotyping results from the discovery cohort are shown for cases and confrols in Table 45. The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rs900743 has the following case and confrol allele frequencies: case Al (G) = 0.92; case A2 (T) = 0.08; confrol Al (G) = 0.90; and control A2 (T) = 0.10, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays.
TABLE 45
Figure imgf000166_0002
Figure imgf000167_0001
[0300] The TM7SF3 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 43 and 44. The replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 46 and 47, respectively.
TABLE 46
Figure imgf000167_0002
Figure imgf000168_0001
[0301] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure IG for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis provides the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure IG can be determined by consulting Table 45. For example, the left-most X on the left graph is at position 27004780. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0302] To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of* a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10"8 were truncated at that value. [0303] The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
Example 11 LOXLl Region Proximal SNPs [0304] It has been discovered that rs8818 in the untranslated region (UTR) of the lysyl oxidase-like 1 (LOXLl) gene is associated with occurrence of osteoarthritis in subjects. LOXLl is a Lysyl oxidase- like protein that catalyzes the cross-linking of collagen via lysine residues. Deficiency of the related protein, lysyl oxidase, causes a form of Ehlers-Danlos syndrome. LOXLl likely is a secreted protein and its biological activity may be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant LOXLl protein or functional fragment thereof. [0305] Fifty -eight additional allelic variants proximal to rs912428 were identified and subsequently allelotyped in osteoarthritis case and confrol sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 48. The chromosome positions provided in column four of Table 48 are based on Genome "Build 34" of NCBI's GenBank.
TABLE 48
Figure imgf000170_0001
Figure imgf000171_0001
Assay for Verifying and Allelotyping SNPs [0306] The methods used to verify and allelotype the 58 proximal SNPs of Table 48 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 49 and Table 50, respectively.
TABLE 49
Figure imgf000171_0002
Figure imgf000172_0001
TABLE 50
Figure imgf000172_0002
Figure imgf000173_0001
Figure imgf000174_0001
Genetic Analysis [0307] Allelotyping results from the discovery cohort are shown for cases and confrols in Table 51.
The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and confrol pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rsl048661 has the following case and control allele frequencies: case Al (G) = 0.725; case A2 (T) = 0.275; confrol Al (G) = 0.767; and control Al (T) = 0.233, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays.
TABLE 51
Figure imgf000174_0002
Figure imgf000175_0001
[0308] The LOXLl proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 49 and 50. The replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 52 and 53, respectively.
TABLE 52
Figure imgf000175_0002
Figure imgf000176_0001
TABLE 53
Figure imgf000176_0002
Figure imgf000177_0001
[0309] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure IH for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p- value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in Figure IE can be determined by consulting Table 51. For example, the left-most X on the left graph is at position 71935363. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0310] To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10"8 were truncated at that value. [0311] Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription.
Example 12 CASPR4 Region Proximal SNPs [0312] It has been discovered that rs 1395486 in the cell recognition protein CASPR4 gene is associated with occurrence of osteoarthritis in subjects. This gene product belongs to the neurexin family, members of which function in the nervous system as cell adhesion molecules and receptors. Like other neurexin proteins, CΛSPR4 contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-li e domains, and thrombospondin N-terminal-like domains. Alternative splicing of this gene results in 2 transcript variants encoding different isoforms. CASPR4 biological activity can be modulated by addition of an antibody, a recombinant binding partner, a binding agent, or a recombinant CASPR4 protein or functional fragment thereof. [0313] Fifty-six additional allelic variants proximal to rsl395486 were identified and subsequently allelotyped in osteoarthritis case and control sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 54. The chromosome positions provided in column four of Table 54 are based on Genome "Build 34" of NCBI's GenBank.
TABLE 54
Figure imgf000178_0001
Figure imgf000179_0001
Assay for Verifying and Allelotyping SNPs [0314] The methods used to verify and allelotype the 56 proximal SNPs of Table 54 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 55 and Table 56, respectively. TABLE 55
Figure imgf000180_0001
Figure imgf000181_0001
TA BLE 56
Figure imgf000181_0002
Figure imgf000182_0001
Genetic Analysis [0315] Allelotyping results from the discovery cohort are shown for cases and controls in Table 57. The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and confrol pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rsl 896753 has the following case and control allele frequencies: case Al (A) = 0.79; case A2 (T) = 0.21; control Al (A) = 0.81; and confrol A2 (T) = 0.19, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" beca_use of failed assays.
TABLE 57
Figure imgf000182_0002
Figure imgf000183_0001
[0316] The CASPR4 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 55 and 56. The replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 58 and 59, respectively.
TABLE 58
Figure imgf000183_0002
Figure imgf000184_0001
TABLE 59
Figure imgf000184_0002
Figure imgf000185_0001
[0317] Allelotyping results were considered particularly significant witt a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated ira bold. The allelotyping p- values were plotted in Figure II for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10 of the p-value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the confrol group for each SNP designated by an X or other symbol on the graplxs in Figure II can be determined by consulting Table 57. For example, the left-most X on the left graph is at position 76177855. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0318] To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). Th e black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10"8 were truncated at that value. [0319] Finally, the exons and infrons of the genes in the covered region are plotted belo V each graph at the appropriate chromosomal positions. The gene boundary is indicated by the brok en horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at "the 3' end of each gene to show the direction of transcription.
Example 13 APOL3 Region Proximal SNPs [0320] It has been discovered that SNP rsl32659 in APOL3 is associated with occurrence of osteoarthritis in subjects. APOL3 belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. It has been shown that the APOL1-APOL4 gene cluster on chromosome 22 exists only in primates (humans and African green monkeys) and not in dogs, pigs, or rodents, suggesting that this gene cluster has arisen recently in evolution (Monajemi et. al., Genomics 79: 539-546, 2C02). Six transcript variants encoding three different isoforms have been identified. [0321] Expression of this gene is upregulated by tumor necrosis factor-alpha in endothe lial cells lining the normal and atherosclerotic iliac artery and aorta (Horrevoets et. al., Blood 93: 3418-3431, 1999). APOL3 is genetically linked to OA and may play a role in the pathophysiology of OA. brought about by inflammation. APOL3 is likely inhibited by a small molecule inhibitor or by specific antibodies. APOL3 activity may be increased in a subject by administering APOL3 recombinant protein or a functional fragment thereof. [0322] Two hundred-nineteen additional allelic variants proximal to rsl 32659 were identified and subsequently allelotyped in osteoarthritis case and confrol sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 60. The chromosome positions provided in column four of Table 60 are based on Genome "Build 34" of NCBI's GenBank. TABLE 60
Figure imgf000187_0001
Figure imgf000188_0001
Figure imgf000189_0001
Figure imgf000190_0001
Figure imgf000191_0001
Assay for Verifying and Allelotyping SNPs [0323] The methods used to verify and allelotype the 219 proximal SNPs of Table 60 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 61 and Table 62, respectively.
TABLE 61
Figure imgf000191_0002
Figure imgf000192_0001
Figure imgf000193_0001
Figure imgf000194_0001
Figure imgf000195_0001
TABLE 62
Figure imgf000195_0002
Figure imgf000196_0001
Figure imgf000197_0001
Figure imgf000198_0001
Figure imgf000199_0001
Figure imgf000200_0001
Genetic Analysis [0324] Allelotyping results from the discovery cohort are shown for cases and controls in Table 63.
The allele frequency for the A2 allele is noted in the fifth and sixth columns for osteoarthritis case pools and control pools, respectively, where "AF" is allele frequency. The allele frequency for the Al allele can be easily calculated by subtracting the A2 allele frequency from 1 (Al AF = 1-A2 AF). For example, the SNP rs2010605 has the following case and control allele frequencies: case Al (A) = 0.19; case A2 (G) = 0.81; control Al (A) = 0.18; and control A2 (G) = 0.82, where the nucleotide is provided in paranthesis. Some SNPs are labeled "untyped" because of failed assays. TABLE 63
Figure imgf000200_0002
Figure imgf000201_0001
Figure imgf000202_0001
Figure imgf000203_0001
Figure imgf000204_0001
[0325] The APOL3 proximal SNPs were also allelotyped in the replication cohorts using the methods described herein and the primers provided in Tables 61 and 62. The replication allelotyping results for replication cohort #1 and replication cohort #2 are provided in Tables 64 and 65, respectively. TABLE 64
Figure imgf000204_0002
Figure imgf000205_0001
Figure imgf000206_0001
Figure imgf000207_0001
Figure imgf000208_0001
Figure imgf000209_0001
Figure imgf000210_0001
Figure imgf000211_0001
[0326] Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The allelotyping p- values were plotted in Figure 1 J for the discovery cohort. The position of each SNP on the chromosome is presented on the x-axis. The y-axis provides the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the confrol group. The minor allele frequency of the control group for each STSTP designated by an X or other symbol on the graph in Figure 1 J can be determined by consulting Table 63. For example, the left-most X on the left graph is at position 34781551. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined. [0327] To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The generally bottom-most curve is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W.S. Cleveland, E. Grosse and W.M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J.M. Chambers and T.J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a lOkb sliding window with lkb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10-8 were truncated at that value.
[0328] The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3' end of each gene to show the direction of transcription. Example 14 Effect of ADAMTS2 Polypeptides on Biosynthesis of Type II Collagen in Patients with OA [0329] To investigate the effect of ADAMTS2 polypeptides on Type II collagen biosynthesis and processing, human articular cartilage from OA patients undergoing joint replacement is harvested, dissected and maintained as described by Nelson et al. (1998) supra. Type II procollagen levels in osteoarthritic patients and autopsy controls is determined by radioimmunoassay (RIA) as previously described. Allelic variations (e.g., rs398829) are determined for the OA patients and controls by genotyping (See Examples 1 and 2). As type II procollagen is processed by ADAMTS2, increased levels of Type II procollagen in individuals with the allelic variation associated with OA demonsfrates that this variation leads to reduced procollagen processing activity and ultimately to OA.
Example 15 Effect of ADAMTS2 Polypeptides on Type II Collagen Processing Activity [0330] To investigate the effect of ADAMTS2 polypeptide variants on ADAMTS2 collagen processing activity, recombinant polypeptides encompassing the ADAMTS2 variation of SEQ ID NO: 21 at position 733 and a wild-type ADAMTS2 polypeptide are expressed in cell lines such as chondrocytes. Since the allelic variation of ADAMTS2 at position 733 of SEQ ID: NO: 21 will prevent the conversion of the ADAMTS2 pro-enzyme to the catalytically active enzyme, processing of ADAMTS2 pro-enzyme is monitored by SDS-PAGE analysis followed by Western Blotting using antibodies to ADAMTS2 and methods common to someone skilled in the art. Reduced levels of pro- enzyme cleavage are apparent by the increased levels of immunopositive protein of higher molecular weight than of the cleaved active protein.
Example 16 Gene expression profiling in IL-1 beta and PMA stimulated SW1353 cells [0331] The human chondrosarcoma cell line, SW1353, (ATCC HTB-94) was grown in L-15 media containing 10% FCS. Culture conditions were at 37 degrees with 0% CO2 with media changes every 2- 3 days. SW1353 cells were grown to 80-90% confluence in 10 cm dishes and then stimulated with either lOng/ml IL-1 beta (human recombinant, Research Diagnostics) or with 200nm PMA (Sigma). IL-1 beta stimulation was for 3 and 24 hours and PMA stimulation was for 3 and 24 hours. Control cells were grown and extracted in parallel with treated cells. ILIRLI was seen to be upregulated by ILl-beta and by phorbol esters in a human chondrocyte cell line model (SW1353 monolayer cell line). [0332] The expression profiling in IL-1 beta and PMA stimulated SW1353 cells grown in 3-D alginate cultures W1353 cells were cultured as above and then resupended in 1.2% alginate beads at a density of 4 millions cells/ml according to the manufacturer (Cambrex). Cells were grown for 2 weeks and an alginate bead was removed from culture and tested for the presence of proteoglycans by Alcian
Blue staining (Sigma). Positive staining indicated that the chondrocytes were expressing ECM proteins. Alginate cultures were then stimulated with IL-1 beta for 24 hours or with PMA for 3 hours. Confrol cells were grown and extracted in parallel with treated cells. ILIRLI was seen to be upregulated by ILl-beta and by phorbol esters in a human chondrocyte cell line model (SW1353 3-D alginate cell line).
RNA extraction and cDNA synthesis [0333] Cells from control chondrocytes and stimulated chondrocytes were isolated at the appropriate time period. mRNA "was isolated from total cell lysates using poly dT beads according to the manufacturer (Dynal). Isolated mRNA was used to generate cDNA using Superscript II reverse franscriptase according to the manufacturer (Invitrogen).
Expression profiling using semi-quantitative PCR [0334] cDNA levels were normalized using the housekeeping gene, GAPDH. Specific primers corresponding to MMP8 and MMP13 were used in semi-quantitative PCR as positive indicators of induction of an osteoarthritic phenotype. All specific primers used, including MMP8, MMP13, BVES, CHDCl and ILIRLI (transmembrane form, soluble form, soluble isoform 1 and soluble isoform 2) for semi-quantitative PCR and are listed in Table 66.
TABLE 66: Primer Sequences for Expression Profiling
Figure imgf000213_0001
[0335] In a human chondrocyte cell line model, ILIRLI was seen to be upregulated by ILl-beta and by phorbol esters. ILIRLI has an unknown function, but it may possibly mediated inflammatory responses that can contribute to the development of OA. ILIRLI is druggable by antibodies or by protein agents.
Example 17 In Vitro Production of Target Polypeptides [0336] cDNA is cloned into a pIVEX 2.3-MCS vector (Roche Biochem) using a directional cloning method. A cDNA insert is prepared using PCR with forward and reverse primers having 5' resfriction site tags (in frame) and 5-6 additional nucleotides in addition to 3' gene-specific portions, the latter of which is typically about twenty to about twenty-five base pairs in length. A Sal I resfriction site is infroduced by the forward primer and a Sma I restriction site is infroduced by the reverse primer. The ends of PCR products are cut with the corresponding restriction enzymes (i.e., Sal I and Sma I) and the products are gel-purified. The pIVEX 2.3-MCS vector is linearized using the same resfriction enzymes, and the fragment with the correct sized fragment is isolated by gel-purification. Purified PCR product is ligated into the linearized pIVEX 2.3-MCS vector and E. coli cells transformed for plasmid amplification. The newly constructed expression vector is verified by restriction mapping and used for protein production. [0337] E. coli lysate is reconstituted with 0.25 ml of Reconstitution Buffer, the Reaction Mix is reconstituted with 0.8 ml of Reconstitution Buffer; the Feeding Mix is reconstituted with 10.5 ml of Reconstitution Buffer; and the Energy Mix is reconstituted with 0.6 ml of Reconstitution Buffer. 0.5 ml of the Energy Mix was added to the Feeding Mix to obtain the Feeding Solution. 0.75 ml of Reaction Mix, 50 μl of Energy Mix, and 10 μg of the template DNA is added to the E. coli lysate. [0338] Using the reaction device (Roche Biochem), 1 ml of the Reaction Solution is loaded into the reaction compartment. The reaction device is turned upside-down and 10 ml of the Feeding Solution is loaded into the feeding compartment. All lids are closed and the reaction device is loaded into the RTS500 instrument. The instrument is run at 30°C for 24 hours with a stir bar speed of 150 rpm. The pIVEX 2.3 MCS vector includes a nucleotide sequence that encodes six consecutive histidine amino acids on the C-terminal end of the target polypeptide for the purpose of protein purification. Target polypeptide is purified by contacting the contents of reaction device with resin modified with Ni2+ ions. Target polypeptide is eluted from the resin with a solution containing free Ni2+ ions.
Example 18 Cellular Production of Target Polypeptides [0339] Nucleic acids are cloned into DNA plasmids having phage recombination cites and target polypeptides are expressed therefrom in a variety of host cells. Alpha phage genomic DNA contains short sequences known as attP sites, and E. coli genomic DNA contains unique, short sequences known as attB sites. These regions share homology, allowing for integration of phage DNA into E. coli via directional, site-specific recombination using the phage protein Int and the E. coli protein IHF. Integration produces two new art sites, L and R, which flank the inserted prophage DNA. Phage excision from E. coli genomic DNA can also be accomplished using these two proteins with the addition of a second phage protein, Xis. DNA vectors have been produced where the integration/excision process is modified to allow for the directional integration or excision of a target
DNA fragment into a backbone vector in a rapid in vitro reaction (Gateway™ Technology (Invitrogen,
Inc.)). [0340] A first step is to transfer the nucleic acid insert into a shuttle vector that contains attL sites surrounding the negative selection gene, ccdB (e.g. pENTER vector, Invitrogen, Inc.). This transfer process is accomplished by digesting the nucleic acid from a DNA vector used for sequencing, and to ligate it into the multicloning site of the shuttle vector, which will place it between the two attL sites while removing the negative selection gene ccdB. A second method is to amplify the nucleic acid by the polymerase chain reaction (PCR) with primers containing attB sites. The amplified fragment then is integrated into the shuttle vector using Int and IHF. A third method is to utilize a topoisomerase- mediated process, in which the nucleic acid is amplified via PCR using gene-specific primers with the
5' upstream primer containing an additional CACC sequence (e.g., TOPO® expression kit (Invitrogen, Inc.)). In conjunction with Topoisomerase I, the PCR amplified fragment can be cloned into the shuttle vector via the attL sites in the correct orientation. [0341] Once the nucleic acid is transferred into the shuttle vector, it can be cloned into an expression vector having attR sites. Several vectors containing attR sites for expression of target polypeptide as a native polypeptide, N-fusion polypeptide, and C-fusion polypeptides are commercially available (e.g., pDEST (Invifrogen, Inc.)), and any vector can be converted into an expression vector for receiving a nucleic acid from the shuttle vector by introducing an insert having an attR site flanked by an antibiotic resistant gene for selection using the standard methods described above. Transfer of the nucleic acid from the shuttle vector is accomplished by directional recombination using Int, IHF, and Xis (LR clonase). Then the desired sequence can be transferred to an expression vector by carrying out a one hour incubation at room temperature with Int, IHF, and Xis, a ten minute incubation at 37°C with proteinase K, transforming bacteria and allowing expression for one hour, and then plating on selective media. Generally, 90% cloning efficiency is achieved by this method. Examples of expression vectors are pDEST 14 bacterial expression vector with att7 promoter, pDEST 15 bacterial expression vector with a T7 promoter and a N-terminal GST tag, pDEST 17 bacterial vector with a T7 promoter and a N- terminal polyhistidine affinity tag, and pDEST 12.2 mammalian expression vector with a CMV promoter and neo resistance gene. These expression vectors or others like them are transformed or transfected into cells for expression of the target polypeptide or polypeptide variants. These expression vectors are often transfected, for example, into murine-transformed a adipocyte cell line 3T3-L1, (ATCC), human embryonic kidney cell line 293, and rat cardiomyocyte cell line H9C2. [0342] Modifications may be made to the foregoing without departing from the basic aspects of the invention. Although the invention has been described in substantial detail with reference to one or more specific embodiments, those of skill in the art will recognize that changes may be made to the embodiments specifically disclosed in this application, yet these modifications and improvements are within the scope and spirit of the invention, as set forth in the claims which follow. All publications or patent documents cited in this specification are incorporated herein by reference as if each such publication or document was specifically and individually indicated to be incorporated herein by reference. [0343] Citation of the above publications or documents is not intended as an admission that any of the foregoing is pertinent prior art, nor does it constitute any admission as to the contents or date of these publications or documents. U.S. patents and other publications referenced herein are hereby incorporated by reference. Nucleotide and Amino Acid Sequence Examples [0344] Table B includes information pertaining to the incident polymorphic variant associated with osteoarthritis identified herein. Public information pertaining to the polymorphism and the genomic sequence that includes the polymorphism are indicated. The genomic sequences identified in Table B may be accessed at the http address http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=snp, for example, by using the publicly available SNP reference number (e.g., rs910223). The chromosome position refers to the position of the SNP within NCBI's Genome Build 34, which may be accessed at the following http address: www.ncbi.nlm.nih.gov/mapview/map_search.cgi?chr=hum_chr.inf&query=. The "Contig Position" provided in Table B corresponds to a nucleotide position set forth in the contig sequence (see "Contig Accession No."), and designates the polymorphic site corresponding to the SNP reference number. The sequence containing the polymorphisms also may be referenced by the "Nucleotide Accession No." set forth in Table B. The "Sequence Identification" corresponds to cDNA sequence that encodes associated target polypeptides (e.g., PADI2). The position of the SNP within the cDNA sequence is provided in the "Sequence Position" column of Table B. If the SNP falls within an exon, the corresponding amino acid position (and amino acid change, if applicable) is provided as well. The amino acid found to be associated with OA is in bold. Also, the allelic variation at the polymorphic site and the allelic variant identified as associated with osteoarthritis is specified in Table B. All nucleotide and polypeptide sequences referenced and accessed by the parameters set forth in Table B are incorporated herein by reference. Genomic nucleotide sequences for PADI2, APOB, IL1RL2, ILIRLI, WASPIP, ADAMTS2, BVES, TM7SF3, LOXLl, CNTNAP4 / CASPR4 andAPOL3 regions are set forth in SEQ ID NO: 1-13, respectively.
TABLE B
Figure imgf000217_0001
ro
Ol
Figure imgf000217_0002
[1] Contig Accession Number which can be found in the NCBI Database: http address: www.ncbi.nih.gov/enfrez/query.fcgi [2] Sequence Identification or Nucleotide Accession Number which can be found in the NCBI Database: http address: www.ncbi.nih.gov/entrez/query.fcgi [3] "A" column is the sequence orientation ("F" is forward, "R" is reverse).
[0345] Following are genomic nucleotide sequences for a PADI2 region (SEQ ID NO: 1), a APOB region (SEQ ID NO: 2), a IL1RL2 region (SEQ ID NO: 3), a ILIRLI region (SEQ ID NO: 4), a WASPIP region (SEQ D NO: 5), a ADAMTS2 region (SEQ ID NO: 6), a RrøS region (SEQ ID NO: 7), a TM7SF3 region (SEQ ID NO: 8), a P-ϊXβ region (SEQ ID NO: 9), a ZQZZJ region (SEQ ID NO: 10), a CNTNAP4 / CASPR4 region (SEQ ID NO: 11), a GPR50 region (SEQ ID NO: 12), and aAPOL3 region (SEQ ID NO: 13). The following nucleotide representations are used throughout: "A" or "a" is adenosine, adenine, or adenylic acid; "C" or "c" is cytidine, cytosine, or cytidylic acid; "G" or "g" is guanosine, guanine, or guanylic acid; "T" or "t" is thymidine, thymine, or thymidylic acid; and "I" or "i" is inosine, hypoxanthine, or inosinic acid. Exons are indicated in italicized lower case type, introns are depicted in normal text lower case type, and polymorphic sites are depicted in bold upper case type. SNPs are designated by the following convention: "R" represents A or G, "M" represents A or C; "W" represents A or T; "Y" represents C or T; "S" represents C or G; "K" represents G or T; "V represents A, C or G; "H" represents A, C, or T; "D" represents A, G, or T; "B" represents C, G, or T; and "N" represents A, G, C, or T.
PADI2 genomic sequence ("SEQ ID NO: 1)
>16:PADI2
GGCTCAGAGGCACCGCAGAGCCTCCCGGGCCAGGGTCTGCACTGGTCCCA[A/G]CCACACACAGTAAGACACTGGAAAAACCAAC TCAACAAATGTGTCCAGGT
APOB genomic sequence (SEQ ID NO: 2)
>2: 21188451-21288350
1 attatgcaca catggtctgt aaccttttaa aatacgagtg tgggaaaaca gcacattctg
61 ccacatccct gaccaaaaat tcctgacagg tggcagccgg cctcttagca acgccaccag
121 gagcctggag ttatccaggg gccacggtgg ttcccttagg ccaggtacag ggcggagttg
181 ggagacctcc tgctgggagg aaggagccca tgaaggcagc gctcagcctc cagagccRcc
241 ctgtgacagg tcaggggaca gccttggatg ggccatgaga gcccacctcc tgtRYcccct
301 taaggtggtc ccccggcttt ccaccagact gggagactca cagggaKgca gtttgtttgc
361 tgtgctaaga aaatttccca agactctgtg ctgggcactg agtgcagcca catccctgca
421 caagactccc ttctcacctg ctcacccagg ccctctcaca ctaccttgtt ccaagtggcc
481 tgatattctg cctgctaggc acacatagtc tgtacccttt taaggtacaa gtggggaaga
541 aggacacttt ctgtcacgtc cattaccaca aattcctgac aggtggcagc tgggctctgt
601 gggaaaagga ccaacatgct cagttgagct tagcacctcc tgaggcctcc ttagcaaggc
661 tggagcctgg cctgtggagg agacaggtgt cccagctgtg gcccagaagt gtgcaaaggt
721 tgagggtgag aaggtggaaa gactatgggg ttgggcaagg aggtataatc tccgcttgga
781 gcatggctgg aggagagcag gtaatggagg ggtggggagg gctcccagga aggagggcct
841 gagcagggca tgaacaggcc agagaaacag ggtgaggaag ggttctggga aggaacaggc
901 caaggtgtgg gccttgggtg gagtttcggg ggatgcgaag cggaggctgt aataatgcac
961 agcacgcttg ctctggactg ttttgggctc ggacacagag cagtccctag gctgagagac
1021 cccaatggag tggggacagg caacattctt cgtggtacct ctgtctccag tgggcctgtt
1081 gtggggatgc atcttctgac aaacccgtct cttttggggt agatgagaat tcctggagat
1141 ccaggaatgc agccttcagg cctgggtttg ttctccccgg agtctctgtg acctggcctc
1201 ccagagagct gagggtaggt ctgcactggc ccctaccttc tgacagacac aaagcagagc
1261 tggttgtaaa aacttaatta aatgaaatat tttaacaaga aattcctaga acagaatgcc
1321 ctgctcgtaa gcaagccatc acagaaataa aagctgacag aaagcgtgtg ttctgtccag
1381 gaagagaaag tttctgcaag aaacaagata gtgcagagag ctggMctgtg ctggaccagt
1441 ggctgagcaa gcttgttcct ggagtcaaag ccaggcagac tcgggacaca gccctggggc 1501 tgtgactact tggctcagga atgcgtgaac tccagaccat aattcaggca ttccacacac
1561 ttttcctgag cacctactgt gtgctgggca gtgtgccggg ctctgggtat acaatgcctt
1621 cggcgttcac caggtgctcc tgtgagaggg ctattttgca agatgaagaa atgggggctt
1681 agggaagtga tgcaacaggg taccactgag gcagagctgg gactggaact caggtctgcg
1741 aatcttcaag tccaagctct ttaccacctc acctactctt tacacaacag ctcagttagc
1801 aaaggtgctg aagaggaaac tcgactgcat ttgcaggctg ctaaattgtg gctggcccca
1861 tgcaaggcca cctctggggc tggagtgtgc cattgtacct tcctggggga atgcaaccaa
1921 atcctgtcct cacactggag tgagagtgga cagagacact cattcccata ctgaggaaag
1981 ggcccgcaga tcagagtgtg tagcttgcat agtggacttc ctggaggagg tggcacttga
2041 gaggaccttg aatgtttctg tagagagtca ggggaggatg tgcccctaca taggagggga
2101 aagggagtaa gccacacctg agagtgggca gcagagcatg gagtgatgcg aagtggcagg
2161 aggagcctgc actggaggcg agagtggagc ctggctcagg gactgactct ccagggaaat
2221 gttgccctct gcatgtgtca gtaaggatga ggtgacagaa acatctcttg ctcccttgcc
2281 catctcgggt gagtgtgaga gaaatgcatt gcatgcacaa gccaaggaac tgccttgatt
2341 tctcctgatt gattatttcc caggctagaa gggttttggg aacagcagag tcaaatcctt
2401 cctgccaccc ggtgcctttg ttccacacca tcttccagtg gcctcagtag gacttggctc
2461 agggccaacc tgatttaaga aaattccatc aaaaaatcct gacatgcaaa gaagactcat
2521 tttaggtaaa atggttcaca gggtaagagg aaactttgtt ttacaggaat attctccatc
2581 aggttatctt atattgtaaa tttcaaatat tctttgattt attcaaggaa atgcccaaac
2641 tttacaggat atggtgagcg cgtaaagtga gacagggctg tgttttgttc agaaattagc
2701 ttacaagtgc ctcttttttg cagcagagaa attatcttta aactctatcc cctacactcc
2761 cccaaggact cagcccccta ctgccccagg gagtctggag aaggaaaggg gagtctaggg
2821 gcgggctagt cctatgtttg gatgactctc tgcctctggt attattgggg agttgaggtt
2881 gtatgtgcac tccgtcccag catcatggct ttgccccatt cacagagctg agggggagac
2941 cctgcatcca cggcttatct ctgtacctgt cataggaaag agtcagccct gcatgggcag
3001 ccagacctgt gagtggggag gcagggtgcc cgggacgggg aggcagaggt ggaggctaaa
3061 cccactcaat agagcatgac agcaagccct cagtcagcct catgaaactg cagccccttc
3121 catctcccat ccaaaccttt ttctgagaga acaagcctag aaatgccact ttagtgtgtg
3181 tgcttagcca gtcagaggac ggcagcacac accagtgctg agtgagttgt ctcagaggca
3241 tccatgcaag ggaatgattg ttttcagcaa actcagggaa tccccaagag gaggcccttc
3301 aattacccag ccactaggtg agacatggag gaaaactgac gagacctcag gggaagcccc
3361 ttggaagggc ctggttgatt tcagtttggc ctggggagtg acacaggcga ggacaactag
3421 atcaaggcaa gcacgtggcc tgggtgtgct tcagcaggga tcggggggtc ttcaaggact
3481 aagagacatt ctttgctggg ccttggagga tttttgtata gagaataaaa agaaacggtc
3541 acagaggcga aaagcttaga tggtatagaa ggacccgggc tcattcagtt catctggagc
3601 atgttattgt tctctgagtt cccattttac agatgaagta actgatgaac agagaggtga
3661 agtgactgtc ccaggacccc atggctggcg agtggcacac ttggaactca cacccacgtc
3721 tgtctcccaa gtgtgctctg tgacctcctg cctcttctgt ctccgtgatc ccagaatccc
3781 tataagtcct cctcatttgg gcccctccca gattgaacac catgtccagc ctcctacatc
3841 agtgccttgt ttatttctct gccctgaatg cttaggagaa tgcctggcct agagaagggg
3901 cttaacaaat agctactgaa gcaataattt tgccttgaga aggaagattt catctgtcca
3961 aaaatctcag gtgaagagga gaaggaagca cgaaatcatt taagtgcttc ataaaagcca
4021 tgcacttaaa ggctttacct ttttctcctt tgttttaatt cattaaatac ataatataac
4081 taagtcaatt agtagtgcca taagcaccta caaactcacc ctccagcatg agaatgaggg
4141 catgagggtc acccacgttg acccatgagt cctcaccctc ccttccctgc ctctccccac
4201 cagatcgtaa cctatccgga atgttgagtt tagcattccc tggcttcaaa actataatcc
4261 tagaaaacaa agcattttgt tcttgatttt aactatatta aaagagtctg gcagccgggc
4321 tcagtggctc atgcctgtaa tcccagcact ttgggaggct gaggtggatg gatcatgagg
4381 tcaggagatc aagaccatcc tggccaatgt ggtgaaaccc catctctact aaaatacaaa
4441 aaattagccg ggcgtggtgg cacatgccag taatcccagc tactctggag gctgaggtag
4501 gggaatcgct tgaacctggg aggcggaggt tgcagtgagc caagatggcg ccactgcact
4561 ccaacctggt aacagagcaa gactccgtct caaacaaata aacaaacaaa caaaaacaaa
4621 aataaaaaca aacacaaacc aaaaaaccca aaagagtctg gcactgcatt tcatcttcca
4681 ggacttgcat tcttattccc tattatgttg tggtcagatt cctctaagta gttgagtata
4741 attgtaattg tacgtcattt attttgactt ctgtcaatag aaaaccatcg atgcattcat
4801 tcgctgtttg ccaggctcca tgtatgttaa cctcatttaa tctttgtaac aactctgtaa
4861 cataagatgg ggccactttc tcctcctgct Yagagttgct taacctattt ttctcattga
4921 tctccatttt aatgatgaaa actgaaggtt aggaaactca agtgactttt ctgaagttaa
4981 ataactcatg aatgatgaag cttgaatttg agagcgggga cttcttttga gaggagggaa
5041 gtattgactg ccttggttcc cagcctcagc tcaacagagc tatgggKcag cagtcggccc
5101 tctctattgt tctttccagg atcatccaac atcccatgtg attatagaaa tgttctaatg
5161 actctagctc tgatcccact tcaaaggctt taggtctcct ggagctatac tgagctccat
5221 tactccagaa agaccttggc accagcctgg atgagcccca cctgatgaaa aagcagagga
5281 atggagagag aattggtgga gctgggctat tggtccagct gtgctttcct taggcactgt
5341 ttctgggtta gaatctaaac tctggatgcc tctgctcact gtggtttggt gttcatgctg 5401 cacagctgac agcccaagcc acagtttaaa aacaagggtg gggacacagg tcttcagttc
5461 atgaaccagt ccaccttcaa ggcctgagtc atccctctca ccccaagaat gggctttggt
5521 ggtgtcagtc cagggagtaa aatggacaca agtgtcagtg ttagcgccta gtgccctggc
5581 attgttgact tgaagcactg ctcagatctg gggaaggcat gagccagtct atgtagcaga
5641 ataaaggcag ggccctctcc ttgtggaaac atgtgcacct actccaccaa cttttatgag
5701 gccctggaat gttatttgtt ggtgaccacc caaccatccc accaacaaat ggagcactct
5761 gaagggagtt acagctgacc tcttaatgtg aaacagcata caaggagatg agctaagagg
5821 tagggtctgt ttctgcacat ttatctctgg ttattagaca cttttagagg gaacatctgt
5881 ttgtccactc tggctcccat attgcaggcc ccatttgagg gccagcttgg ccccttctct
5941 gactgaattg ggactaagtc ataaattaga ttcagaaggg gacctagaat agggagttag
6001 agggggcttt gctcaactca ccaaaaaagg ggaattgagc tattcaactg accgggcttc
6061 aagtaaaaag cagaagaaaa tggaggtagc tctgaagaca tctggtggtg ctgagtccca
6121 ttggacccat ttcttatcag gtttatcctg aggacagcac cactactcta ggcgggacct
6181 gggagtcaaa ccaaagcaca cagcttgatc atgcttctga agccccaggg acttgggctg
6241 ggctccatta tttgatttct cctttggttg aaaactttag atatttgttt aatgggagga
6301 atatctgtat ttatagcagg actttccacg tcacctcaca gtatgttctt agcagatgta
6361 cctgttgact tactcccagg acaatagggc aattaactgt acaaaaggaa aaactctttg
6421 ttttcttgtt aagtttctaa agatacttat acaaacataa aattaatgca attattggtt
6481 aaaatcctca tttttcccta ctcctttgga tattgtttct ctagcccaca tttccaactg
6541 gcctgctaga tatctctgct tagacacatg attgcaaatg gaaactcact atgtgatcca
6601 gtagtcccat tccagctgtg atagtcaatg agtccatgtc ttatactaat aatctcccac
6661 tcaacacatt cctcccattt ctactgaggc tccatagtcc ttcaagttac acaggttcgg
6721 aatttcctaa ctctgaagtc tgctttacct attcttcctt gttcctatgt tcctctctct
6781 ctctcctgca acccctccag ttcccggctt cagtgactta ccaaggcaac tccatttcta
6841 agagcttttg cacccatcct ttgtgtttta ctcaatcagc cacctgattc tgtcaattct
6901 gccttcccaa tcttcttcta tcctaccctc ctcaccattc ccaaccctag gacttgactg
6961 aggtgctcct catctgttac ttggaccctg gcacaacctc atagatgtgg tttgggtctg
7021 tgtccccacc caaatctcac Rtcaaattgt aatccacaat gatggaggtg gggcctggtg
7081 ggaggtgact ggatcatggg ggcggatttc tcctttggtg Mtgttctcgt gatagtgagt
7141 gagttatcat gagatctggt tgtttaaaag tgtgtagcac ctccccacac ttcctcctgt
7201 tccagccatg taggttgtRc ctacttcccc tttaacttct gccatgatta taactttcct
7261 gaggcctccc cagtcatgct ttctgtactg cctgaggaac cataagctga ttaaacctct
7321 tttcttttta aattacccag tctcagtatt tctttatagc aatgccagaa cggactaata
7381 cactcatatc cagattcacc ccattacaat tcattatcta taggttgtca tgttggtttt
7441 ccKaaatcac aatgcatgtc acccttctgc tcaaaaactt ttacKggatg tccttcagca
7501 aagagagtgt catcttttta ctctgacatt cgagccctct gcagtactat agatctgcct
7561 ttccagtcct ctctccttac ctttcctgtg ctttggctaa actagataat ccagtgtcct
7621 tacaacacac ccaactatca ttctttactc gtcttcttcc tagaccaccc tctctctcat
7681 ctgtttatta aagtcaatgt atattcgaga tccatttcaa tcttttctat aaaaatcccc
7741 tgattcacaa ctttcctctt ttaaatccct catagtactt tggttatatc caccatgaga
7801 aaacacgttt cacctttgac agataaatgg gcagacagac ctccaggaac tgcatcttat
7861 tgatctctgt ctcctctata gagccactgc acagtgcctt acacatagag gtgttttatc
7921 aatgcacact gaaccagaca cgtagccctg cctccattct ttcttcttgc cataacgtca
7981 ttttaataat catctaatga taatggcagc ttttctctac aggacattaa aggttgcaga
8041 actctcatat atgttatttc aactgatttt catgaaaagt cctgcaaggc aggcaggata
8101 gatattatct ccatttcata ggtaagagaa ctgaggcttg cagaggtgaa ataagttgca
8161 ctgagtacaa gcaaataaaa aatgtagcta ttaattgaac cagagaagta tccagatatg
8221 cagtagaaga cctaagaagg gagcaggcaa agtccaagtc cccacaagga tcccttgttc
8281 ttcaaacttt attcagtaca acaaagacat tctgagctca tcaggggccc tttgtatgag
8341 ggacactggt caaggaactg ggcagtgggt accatgtgac tgcacaatca ttttggattt
8401 gtggctattt ttttttcttt tcagcactag atagatatca acaaataagc actgggaatc
8461 ttggactccc tctttccctc caaattaagc cacaattcca ggcctccttt cagtttgaac
8521 actcactaaa tttttgctgc ttatagctca tcagggaaac tcttgcagaa ctattcctgg
8581 aactattcca tgtggtgcct tgggatttga gtctaatttc catgtttctc tcactctcaa
8641 aactgacccc tcatttatcc actcatttat tcgctcaccc acccatccat ccatccatcc
8701 atccatccat tatccaacag actttccttg agtaccagat tcatacacta ccgtattata
8761 gctccataga ctctttctca ctcttcagtt cagtacagaa gaatattgtt aaggctatgt
8821 gtttcctttt ccaggtaacg cctgtgcatt ttaacagtgg gcttcaccaa gagaatgtga
8881 agctttatga aagaatggtg gaggttgaag gatttttgaa ttaaaaaagg aggtcttttc
8941 caaatagacc tcatgtagga tttgggaggt ggtgacctcc aatttcttat tgcccccaag
9001 ttacactctt ctttgctctt cagtgtcatg gaaaagaatg cgctgtttta tatctaccct
9061 tgtcagtaat atgagtgcaa gttttgttgc acaggttttt tgcagctttc tctttctaga
9121 gctcagcttg gaggctctga ctggatattg ccagtgttta aaatcagagt ttgaagtgag
9181 tggatgtggc aggagaaacc cttgggtttt tactacactt gggattgttg gatattatat
9241 ttggaaaaat aaggatgctt aagagcctaa agagcataca tgtatgctgg gtcacagaat 9301 tgttaggaat ctacatctcc acccctcctc tcccaatcat actttcttgg ccttgaatgg
9361 atcctggcag agctccaggg agacatctgg ggtccgtatt gccatgaagc ccctggggct
9421 aggactccct agccattcct tctccactcc tggcaggctg agtgaaataa aggacttgtt
9481 atttcatctc gaggcctacc ggagagcctt gccttgcaaa ggcagacagt cagtgaggaa
9541 gactatgtgg cacatgaaga caccagaggt gttcctcagg atcaaagtat gtacaagcct
9601 ttgtgaatat tttttccttc tcacttggca aatacaattc ctgagatcaa taacctcgtc
9661 tttttaattt tttcctcgtc tttttaacta tttataaaat attgaattat aaaatatgta
9721 attataaata ctttaattat aaaatatgta attataaata ctttaattat aaaatatgta
9781 attataaata ctttataaaa tatgtaatta taaaatatgt aattataaac attttaatta
9841 taaaatatgt aattataaac attttaatta taaaatatgt aattataaac attttaatta
9901 taaaatatgt aattataaac attttaatta taaaatatgt aattataaac attttaatta
9961 taaaatattt aattataaac attttaatta taaaatattt aattataaat attttaatta
10021 taaaatattt aattataaat attttaatta taaaatattt aattataaat attttaatta
10081 taaaatattt aattataaat actttaatta taaaatattt aattataaat attttaatta
10141 taaaatattt aattataaat attttaatta taaatatttt aattataaaa tatttaatta
10201 taaaaacaca attacctcat ctttttaaat atttttgcaa aatatttccc tccataattt
10261 ctccgtttcc atttttattc tgttacttaa atcacactat gtgttctaga ggttttgctg
10321 tgccagaaca ttttatcaat gccctcgttt cactgtcttt caatacaaat gagccacatt
10381 cagtggtatg atacacaata aagactccat ttatttgttc ctcctccccc aagtttagca
10441 aaataactca gatcctgatt ttctttaact tgcaaaaaat gccatccttc tgagttcaga
10501 gaccttccga gccctggtgc cagctttggt gcaggtccag ttcatatgtg cttctgctta
10561 tagtctactg cctactgcaa ggctggctca ctgtatggtt ttatcaatat aggcagtttg
10621 aattttttct gtgctatgtg aaagttcaat tggaaaagaa gaataaatga agatttcttt
10681 taaaaaatta gaggatgata gtaagttctc ctggagcaag cttcatgtag gggttcatga
10741 ctgtggttga ttgcagcttt ttcagtaact ccgtgatgta tatcagaaat gtgtggtagt
10801 tttgaatgga caggtcaatc aatcttttgg attcagcaat aaatttttca tagtaatcag
10861 agagttggtc tgaaaaatct tgcagtttat atctaaactg ctggtggtaa tcagaaatta
10921 ttttcttcgt cgcaatggYc tggcttttaa ttatttcctg agcagtggca gaaagctctg
10981 caatcttctc tttccctttt ccatctggat cggtaaggat gctaagatat tcctgaatat
11041 ttctgtgcag aaattgctca acttgacttg agagttggga agtaaagtta gaggcactga
11101 caatatattc agaatggaag tccttaagag caactaacag gttcttgatc agactgacta
11161 tcttttcttc aagttcataa tatttcactg tccagccaac tatacttgga tcaaaatatt
11221 cttcacgaag ggccataatg tattgatgga tctgctgtaa ctcttgagaa gcttcctgaa
11281 gctcgttttg aataaattca ttgaacttat gaagattaag gcataggttt tctttcaaca
11341 atttaaaaac atatgggata taatcaYtga agattgtgtt gatctcatct tggatataat
11401 taataagata agtaaatttc atctctttca gctgtttaat gttatcttct attagttgga
11461 aaatgaattg taaaaggtcc tgaagattac gtagcacctc tgtggtcttg agagactgaa
11521 tggctttaaa tacctcttgg gcttcttttg ataaatcttt caacagttcc Statacatcg
11581 agattacatc tattagttta tgtttcctta actcgaaagg aagtgtaatc actaggtctt
11641 ggaaatagga aaacagtatt tctgaaccat tatggacttt cgaatatacc tgggacagta
11701 ccgtccctac ctcccttatg aacatagtgc aaagttcctc cctagtgtat atcccaggtt
11761 tccccggaaa ctggaatctg gggaagttca gaaaatcaat gagtgagtca atcagatgct
11821 tgactttcat atggaattYt tgagtaactc gtaccaagcc atcaaacacg ttatccttga
11881 gtccctggaa actggcttgg ccttcctgag tcaacagttc ctggtacaga ttctgggcct
11941 tgtccttcca ctcttggtag gtcccagtgg tgccactggc tgctttctgg aacctcacgt
12001 cgatatcatc aatttgccta atggcccctt gataaaccca ctcagcattg ttctgcagat
12061 ttcttctcag ctttgaagac acttctctca gggtgagccc tgtgtgttcc cagtggtact
12121 tgttgacata atcataaagg acccctgtgg ccttgggcac gttgtctttc agagaggtta
12181 gcaagccaga agctgcctct tcttcccaat taactttgat ctgagtttcc tcatcagatt
12241 cccggaccct caactcagtt ttgaatatgg tgagtttttt atctggagag gactaaacag
12301 agagaaaaaa aaaaataaca tgttttcaat tactccaatt acacaatata gtacactaaa
12361 acttcattag cagttaaaaa taaagatcag agaatctttc atatactgaa agggatttat
12421 ctttcatatg tcagttcatg tgtttgtttt atggttaaat aagtctactg ttgttaattt
12481 ctctttatca catgccccag aaaggattta acaaaaacgc ttgctgtttg tcatttacat
12541 tgtgacactt Raaattaaag ccttcctagg actgaaaact ggaagaggag tggggggaag
12601 agaaagaaga ggagagagaa gaagagtcag gaaatgacag ataggRaaag aagaaatagc
12661 aaaaaaggca agttggagcc caccctgcag agacccagaa tcccaacatc agtacgcatt
12721 ctcσaagccc atgacaaact tttagtaaca gtcatagaac catgtttggt cttctcctct
12781 ggtaatgtca cccttgattt ggccctggca gagcttgtaa atgacatgag aggaatttga
12841 tgtatctcat ctagcaattc tattgtgggg aagaatttta aagttttaaa tactacagaa
12901 accagtcctc tctgaaaaat ataccctgcc tatggctgag cttgcctatg atttagatga
12961 tgaggtataa ccctcatctt cctggatttg cccagaatta ataaataata gtgctgatgg
13021 gatcjtcatgt gtgcatctaa acattaaaat caatcaagga ctcattgtaa tactttctag
13081 agaatatttc ctcagagaag aagttgctta ccgcctgtct ttcacctagt ttggggaatc
13141 tctgaatatt tggtcctgaa ttaaatgtat ctgccccaat tctccactcg ctcttggggg 13201 cgtgtcactc attaggtggt atttacctga gggctgtagt agaagttcca tttagaaaag
13261 tcgtcatctt catccatatc catgcccacg gtgcctacgg ctggggaggc tgctgaggtg
13321 gagatgcctt tcttgtcttt ctggtagcgc agatggagat cggtgaacgc tgggcttttg
13381 atattgaggt g-cgcttttcc ttcccattcc ctgaaagcag aaaaacagat gagctatcac
13441 gaaaggggta tggagatgaa gaaaatcaSa atgagttttc aaaaggtata aggtttcaat
13501 tcaataaaag ctccatactg aagtccttca tatttgccat cttcttcata ttctgcactg
13561 aagtcacggt g-tgcaaatgt tcctttagtc ttagaggcta acgtaccatc ttcgattttg
13621 tgtgttccca aaactgtata ggagagattt tgtattttat tagattcata acagtaggac
13681 gttgatgttt tcattgtgaa aactgggaga attctatcct aaccagatat ttcacttgtg
13741 tttaaaatat g-caatgtaca gctcacactt attttaaaat aaatagttaa aagacattgt
13801 tagtcctaaa ataattacag aaaaatccat tttctttaaa gctgtttgtc ttgaatgaca
13861 ctagattttc tacagtttgg tttttacgtg tagggtatac atgtatctct tttcttactt
13921 aaaattttgt g-acattgagt aattgtacat ctactcacaa ctaaatacat aattatttac
13981 tcataactct cattgaaaat atacagtatc taggagagga ggcaggatat ttcttaccat
14041 ttagttcata ttctaggaac tgtacggttg agctgcatgt ggaatccagg actgtttcaa
14101 cataatctgc tttgtttttc aaactggcac tccaagtggc attatacacg ggagagtcta
14161 cctcaaagcg tgcagtcagt gcttgaaagg aaggaatgac aattccagca ggtacagaga
14221 acttaatgga gggaatctca atggtctgct caggcacgat gatggtgggc aactcaaagt
14281 ctgcgatctt gjttggctact gcatttagat ccaaagcagc aatgccatct gaaacacttt
14341 ttggaagcgt gaactgggac acagttaact gagattcagg cacggttatc tcaaaaaagg
14401 gaatcaagga gtcttctggt tgagaatatt ttgttaacac atcaacttca gggaatttta
14461 cctcggggag tgttggtagg ttgagggcaa atgatgaagt tctcagcttc ttatagattt
14521 gtatttctct gaagtcaagt ttgcacgatg gaacctgaag atctgtaaat gggacatgga
14581 acgtaggcat gacaagaact gaatttagat catttagttt cagcccagga ataatgaatt
14641 tatcagccaa aacttttaca gggatggaga atgaatagcc attggggttt ttggtgtaca
14701 caaaggcagt fcgaaacacga agatgctgtc tcctaccaat gctggtggtt acatccagct
14761 ttaggaaatc ccataagctc ttgtcataga ctggtaggat gatatttttg aggaacctta
14821 ggtgtccttc fcaaggatcct gcaatgtcaa ggtgtgcctt ttcttggtca ttggaaagct
14881 cgacctggct ctggaaagac ccagaatgaa tcYggacttc atttttccat ctgatcttct
14941 ggttcttagt gttagcattc agggccactt cctggccaag gtcagggaaa tcatggaagg
15001 aactgggctg acttgcatgg acctgaacaa gagctgacat ttgccatgga gagagttcca
15061 gggtggcttt gcttgtatgt tctccgttgg tgaaaaagag gccctctagc tgtaagtggt
15121 ttttcgtact gtgctcccag agggaatata tgcgttggag tgtggcttct ccagcaaaat
15181 tttcttttac t caaggttc cagaKatcat caattttgga agtgccctgc agcttcactg
15241 aagacYgtgt gctcttggaa ttcaagtaag tgttggcctc actagcaata gttcctgaat
15301 attcccgaga aagaaccgaa cccttgacat ctcctttggt agatgactca atggaaaagt
15361 aagaggtgag gctttccaag ctaagcttgt ggtcaactgc tcctttagcg gtagagtaca
15421 gcattgaaga attgaaatca tacttaaatt ccatggagga agagacagta ggttttgact
15481 tggtatttcc attaagttct tgcttgaaat tcattctcaa aattggaatt tgggcttttg
15541 tggttgttgc cactgacact tccatatttt tcgtggttaa gctcacagta ctgttatgac
15601 taccctccac aaatttgttg ctcagagaca gagctgtggc taacttcaat cccctttttc
15661 ttgtcaatct tgtggtgccc tctaatttgt actgYagtgc atcaatgaca gatgaagatg
15721 aagaaaggag atgagcaaca atatctgact ggttaaaaag ttcagcattg gtattcagtg
15781 tgatgacact tgatttaaag gagaaatcat aggtaatatt gcccatggca ggaataaaaa
15841 tatggcttat ggtacacaat tccttgaaat ctggaagaga aagcttgaga tttctaggga
15901 catgaaggac tggcagctct aatgatggca ggattaatgt gtatgaaggc acacggacgt
15961 cagaacctag gatggagaaa ctaggcatgc tgactgcttt tgggaacaca tagccgaatg
16021 ccgacatctc tatggtgaat ggagacactt caacattgac aactggaaca gtgtatccag
16081 gaatttgaaa ggtcctgggg agctcgtcgt gagatttttc agctttgtac ttatcaaact
16141 taatttttgt t tcattatag gatttggtga caaaatctaa tgcattgttt ctgttttttt
16201 caaaatgcct gtcaaaggat ttgatgctct gactgataaa ctcacaaagc acagccaaag
16261 gatttgtgat g-gaatgcctg tgtttgtttt tcttatactg agcttttaca cttaaatcaa
16321 atgattgctt tgtcgttttc aagaattcct tcaagcctgt tttttcccat agagagaaat
16381 ctttcagtgg aggagttgtg attattgtgt aaggtagacg catttcagga attgttaaag
16441 gaatgtttaa gaaatccaga tttgcttctc catttattcc tacatgggcc tccataatgt
16501 tctcgttgtt fc ccagcagag aaattttggt tgtacttata ctgattgaac ctagcactta
16561 cttgccaact fcgcttgctgg gcactgggac tcagaaacag tgcatagtta ttcaggaagt
16621 ctatcttccc tgttaacctt aatggaaaac gaactttcaa attcccttca ttgtttgtgg
16681 atgccgtgat ctcaaatggc tgggctgaaa agaaaagaga atttttcaaa gttccaataa
16741 cctttccatt fcaaatgagca tcatgcctcc cagtaaactc tgccttccct tctccaaaca
16801 gtgccatgcc tttagcagtt agaacactgt ggcccacatg ctgggaatcg acttgtgatt
16861 gaatttcaag tttagaaaag ttgagggagc cagattcata aaccaagttt tggtttactc
16921 ttaggtgttt gctattgatc ttattggaca gtccaaagga agtgaggggt ccttctatgg
16981 tgaaactaat ttgtgattca tgtgttccct catctgagaa tctggggcag gcccatttcc
17041 atgacccttt tccagaagaa gtccatgcta tgtggccagc tttcaacagt gtcttgatct 17101 cgttgcgcag gtcagcctga ctagagaagt ccagtttggg gatgttcaat ttgtggaagt
17161 atttagtgtt gctatccagg gtaagctgat tgtttatctt gacaatcact ccattactaa
17221 gctccagtgt atttttttct gtgtgtaaac ttgccactgt gtttgatttt ccctcaatag
17281 catttccaaa aaacagcatt tcactcccat gctccgttct caggtacttg ctggagaact
17341 tcactgactc cttcagagcc agcggattaa tcttagggtt tgagagttgt gcatttgctt
17401 gaaaatcaaa attgagaact tctaatttgg actctccttt ggcagtgatg gaagctgcga
17461 tacctgcttc gtKtgctgag gtggttccat tccctatgtc agcatttgca tctaatgtga
17521 aaagaggaga ttggattttc agaatactgt atagcttgcc aaaagtaggt acttcaattg
17581 tgtgtgagat gtggggaagc tggaattctR gtatgtgaag gtcaggaact tgaaaatcat
17641 taaggttgag agttgggatt atgaattctg gaattgcgat ttctggtaaa cggaagtctg
17701 gcagggtgat tctcgctaga ggaatgtcct ccaccttcag atccctgaga tatatatctg
17761 gaacgggcca ctgcagctca ctgttcagca tctggtcaat ggttctgatg atctttactt
17821 tcatttcKac aaagtcaatt gtaaaggaag gaatgtggaa ggtgttaagg atggtaaatt
17881 ctggtgtgga aaacctggat gggattttta tattttttaa gtctttgaag tttatctgaa
17941 ctgatggaat cctcaaatct gttaggggga ctataaaatc aggtgtctgg aaggtagctt
18001 tctgaagagc ctgaagactg acttcaaagg caggcatggt cccaaggatg gtcttgattt
18061 caggaacagt gaacccttgc tctaccaatg ctttcatacg tttagcccaa tcttggatag
18121 aatattgctY tgcaaagtca gtaaggttct tagcagcaag agtccaccaa tcagaaatgt
18181 aggtgacaag tgtgctataa acctggccta ccagagacag gtatcgttga agttcctgct
18241 gaatgtccat ttgatacatt cggtctcgtg tatcttctag Rgtctctcgg aatttggcct
18301 tcatgtgagc caaagatgct gaacttaaag cctcctgtaa ccaattgatg attaaggtta
18361 ttttggtgtc ctgtaggctt tccagataca ctgcaactgt ggccttggtt tcctctaaaa
18421 acagttttaa tgcttcagct ttttgtggta gttccagagc ctgaatttca ccattgagtc
18481 tctgagtcac ctcacggatt ttgtcattgg tttcatctac aaactggtgg taatcaaatg
18541 actttaattt ctttatcaac atgtcaagga atttgttaac atcttcaatg aatgttttaa
18601 aagataattc attaagcttc ttSacagcat catcaataaa tccaaccaat ttctcaaagt
18661 aatcttttat cttaacttgt tgtaggacat tgcttagctt ctgaatagtc tccttcaact
18721 tgtattggtg ggccaactct actaatttat ccattaaaac ctggatttgt tggtctactt
18781 catacctctc gattaactca tggactttgg ctctgaaggc attgattttc tcagctactt
18841 caaaatcccc aataagattt ataacaaagt gtttgacatg ctcaagaatR tcatttattc
18901 tttcaaatga aattgtagtt cccaattgat ctaaaagcac tctaacatca atagcctcaa
18961 tgtgttgttt taactttcca gctaggtgct ggatgtctat attctgtatg tgtctcttaa
19021 gctgctgcag tttttcttgt atctggattc tgatttggta cttagtatcc acattttgaa
19081 tccaggatgc agtactactt ccacttttgt taaaatcaat attttcaata aacaaatgta
19141 gatcatggat tgtttttact aaatttacac ggatatgata gtgctcatca agacttttta
19201 atttttcaat gatttcatca ataatattag caatagctat tttcaaatca tgtaaatcat
19261 aactatcttt aatatactga tcaaattgta tcatatatgt ctgcagttga gatagttttt
19321 cattaaagtt gattttggca tcatctaatg caatttgtat atcattttct gtaattctat
19381 acttttttgt gagagcagtc agtttctcct tggcatgtga aacttgtctc tcccaattga
19441 atgaattcag ataatcatta gcttgctgtg ggagttttcc cagggctgct ctgtattttc
19501 ttacaaattg atcaatattg atgtgcttca ggtttctctg tacgttttcc agtacaacta
19561 taatggtttg tcgattcctc tcaaaatatt cttgcaaggt ctcaaaaaat gggaggttaa
19621 tggagtgaac atcttggttt ttatcatact ttacaaaagc aacaattgta aattcttggg
19681 gcttctcaac ggcatctctc atctctaaag catcaatgat attgatgggc tcactgagta
19741 aaagtggcac tttaattggg gagtctagta gagttaggtc agccagagtt cgtccagtaa
19801 gctccacgcc aattttatct ttagtgttgt aagcatccaa gtcctggctg tattcattgt
19861 tgttaaattg ggtcttgagt ttccaggtgc ctgtctgctc agctggagta agcagggcac
19921 tgactttgtg ttcaagagct gcactgatgc ttttcctaga cacgagatga tgacttgtgg
19981 agcctttgta atcatgagag aaagtaaatg ccagaggttc tgctttcaac aggaatttgc
20041 tatacagctg cccagtatgt tctccccaga gagcgagttt cccattgcca tttgtatgtg
20101 catcgatggt catggtaaac ggggccatta cagaacggaa gacattgctg aaatgcagtg
20161 agtctgaatt atagtttgtg ctcatgtcaa tggctgaagc cagcccagcg atgtctgtgt
20221 tgagccgatg gctaaactcc acaccctgaa ccttagcaac agtgtctgct ttatagcttg
20281 ctgataaggc agcagaagag atggcataga tgtgttttat ttcattattt tggtaggctc
20341 cttttaggtt accagccaca tgcagcttca ggggttctag ccgtagtttc ccattgttgg
20401 tgagatccag agcattgtat ttcaggtcac tgtttaaagt agttaccaga gaatagggct
20461 gtagctgtaa attaacagtt tgcttataaa acttgtcaga gctgtaaatg ttgtcaagtt
20521 ttgaagagaa gtccagtgat aagcctgcaa tgttcagact gtttgtgtgg tcaaatttca
20581 tttcagcata tgagcccatc atgtcatttg agagcttaag tccttcttga ctgaccttga
20641 agttgaaaat gtttttgctg tcgacaccca gaatcatggc ctgataagca cttcccagtg
20701 atagctctgt gagggcggct ttcccatcca gactgaattt tgcattgtgt tccctgaagc
20761 ggccatttgt tgttaatttc atagatgccc cagagaggcc aagctctgca ttcagctcat
20821 tctccagcac caggagacta cacttcaagt tggtcgttgc actggtagat attccatctt
20881 ggccaatcct tagtgtcgcc ttgtgagcac cactattaat tttgtcagtg cctaagatgt
20941 cagcatttaa ctcaagacca tgggaattta gtgatccaga aagcaggctg aagaacctca 21001 atgactcgta atcagcctga fcattcagaac gcagcagtgc attttgctta gagaaggtca
21061 tatccatctt gttagaagtg gcaaagttct tatacttccc attggtgtca gattttaaag
21121 tcagctcgta gttctcatac tttagggaag cagtattttt aatgatgcca ctttgcagat
21181 cagaggtgga ggtgagggag agggttccat cttcatatct tcctgttatc tggttggtgc
21241 cttggaggta ggaggagtta aacctcaggt tggactctcc attgagccgg ccagtgttag
21301 gatccctctg acaagacagg ccatatgtgc ctttagcata gaacgaagag actctgaact
21361 gcccatcaat cttgacttct fctgacaaaca aatgctgttt ctttttggag tccaaatgaa
21421 ctgaagcaga catctgtggt ccccaggaac tagatgcatc gaatattagt aaaccttttg
21481 agactgggtt gtttccaagt ttttctacat gactgaattt gatattcgaa tctagaaatt
21541 tgtggcgtag agacccatca Yatgatagtg tgaacgtatt cttgtggtca tatgttgttt
21601 ctccagatcc taacataaaa atgaaaagac attggttaaa ttaagcagta catttccaga
21661 gcaatctcta tgttgaaagt ctttcaataa taaagcccca tttttctggg ccaattgtgc
21721 aatagactcc tccatctgta atgcaaagat aaaatctgat agcaaaaggc attcctccag
21781 gaagccttgc ctgaccacca caggctttgt ttaggttccc ttgttgagtg cttccactct
21841 accttatact tatatactac actttatcat agcacctctc acactgaatt ataattgctg
21901 gcttatctgt ctactttctg ttactgccta ctagaatatt taatacacgt gatatgttta
21961 ataaatattt ctatttgttg aataaaataa aagacttcca agtagcaagg aagattatct
22021 gctagaaagc caaagtcctt tcctccctgg aggaggctct cctcttagag cctgccatga
22081 actagcccgg tgcacccttt acctgagcat agctcacctt gcacattgta ggaaagcagg
22141 tcaaccacag agtcagcctt catgtggtaa cgagcccgaa ggctgaaatg gtctgtgctg
22201 gtgttgccac cactgtagga ggcggaccag ttgtacaagt tgctgtagac attcgtggag
22261 aggtctagaa cacccaggag aggcacttgc agttgataca acttgggaat ggtaaaagta
22321 gggacttgga actctcgaga tggcagatgg aatcccacag acttgaagtg gagggctggt
22381 gtcctaacag tctctaacat ctttagatct ctggaggatt tgccaccaaa aggcaaagga
22441 atctcaattt tcaaactgtt cttgttcaag gtatatttga cccggccatc gctgaaatga
22501 acaacaaaga taacatcccc acagtcagac atcagtcatt caaagttctc tgcctctgac
22561 cttcacaaca atattgtact tgccccattc ccaaagccac tctgcacttt tctttgtgct
22621 actcctatgc ctggacccct ttgcttttac ctccacctgt caaacactca aatcctgaca
22681 aagctcttct aagggccact ccttatcatt accatcccac ctaagtcata gccaatttgt
22741 ctcattctta cagttacata gtcccttgca cctttctcaa agagcatgtc ataattttgc
22801 ttatataatt aattatttct catttgttga tgtctccatg gtatcttctt gaaagaaaag
22861 gctatacctt acccagtttc tatcttctca ctgtacctag tctagcattt tgcacatagg
22921 ggatacttga tacaaatttg ctaaactgaa ttgagacaac ttgatttgtg gaaagaacat
22981 aggtatggaa gtcagtaagc ctgggttaaa gtattttctc agaatgctgc ctccatttag
23041 tgctcaatgg ctgttctgac tctctctagc ttaacagcaa gcctgtagtc aataacgccW
23101 ctagccattc tgaattcttc acagtcagag ggagaatttg cttataacag gttgtactga
23161 ataaaatatc ttagggtgaa agtaccagaa tcctctaatg actttcttag attcttcctg
23221 acagggttgg tgttctcatg tttactaatg caaagatgcc acagtgtttg tgctatagtt
23281 attaatctcc ttaaaatgct taaattattt cctttaaaaa tttaaaaaaa tgtctaaatc
23341 atgctatgta aaatctttca tttactttgc atggttcaag aagccttgct gctttcttct
23401 tttacctttt taagaagagg ttttctggga tgtggaagtc tggcaatccc atgttctgga
23461 ggttgaactc cttcaggcta ttgaggtggt cttgcaaagt ctgggtataa ggaagactcc
23521 cagatgcctt ctgaagccat gagctcattg cctacaaaat gacaggagat ttttaaggta
23581 atgggcttgg atgagcctca aagagcaatg aacattaggc aaaaataccg atttgacaag
23641 ttaattatta agctggacaa tgcactgaaa gttaaaaata aataacagaa aattatgaat
23701 cttcgttgcc agtcactgat cactgtccat atttataaaa ggaatgtcta acatagtcag
23761 cctcctagct ggtgtcctga agcttccttt gataccacta ggcaaagaac tgttctactt
23821 agtagcatct ctttgatatg tatcacattc agctttgtgt aactgggtaa cKacacactt
23881 gtgaaagttt ttttttctcc ccaagaattc cctgggggga aggaagcatg ccttatacat
23941 ctttggaaac cttcctgcac ctagctcaga gttgaggatg taattagcac ttatatccat
24001 gtatttattg actggcagac tcatacttac aactattaat ttggaaccca cgtgccggaa
24061 agtcatgtct gtttgaggga ctctgtgatc caggagtcta ttagcataca tatgcaagct
24121 cttaggataa tcggagagat ccacagggaa attggaagtc atttttttgg tatctacatt
24181 ggtgcctgtg ttccattcaa attcaatctt ctcttcatct gaaaatacgt aggaaatagt
24241 tgtgaatggt actagttcag cctgtaacca caggtctcaa cacctgcatt actttggaag
24301 tgctcacaca ggggaagaga cacataccat aatgccatgc caccctcttg gaaactgtgg
24361 agccataagc tgtagcagat gagtccattt ggagaagcag tttggcaggc gaccagtggg
24421 cgaggatctc acttctggct tctgcttgca aacggggtat ggaaataaca cccttgattt
24481 ttctttcttc ctttgtgtca caactatggt aaagaaaatc agttggcacc aatgattttg
24541 tcctttcaat ggagatatgc aggattaaac agaagttcca W tgtggtga tcaaaaccag
24601 atacaaggat ggttcagaga aacagccaca gatcaaactc atcaacttct aaagccaaca
24661 ttcagcacaa attaaggact ttgcaaacag gtttaggaga aagagaagtt ttttgaaaac
24721 tgtttgaatc ctgctctgct atttactagc tctgtgattt tgaccaaatg atttaacccc
24781 tctgagctac catttcctta tccatgaaac aggaaaactc acagtgacct cgcagtttat
24841 tgtgaggacc gagataattt ctttaaagca cccagcactg tgcttgatac atgaatagta 24901 agtgcctgat aaatggtagg aaaatccaac tggacatgcg cagagggtta aaatgttgag
24961 agcttggccg ggtgcagtgg ctYacacctg taatcccagc actttgggag gccaaggcag
25021 gtggatcacg aggtcaggag atcgagacca tcctggtcaa tatggtgaaa ccctgtctct
25081 actaaaaata taaaaattag ctgggtgtgg tggcatgcac ctatagttcc agctccttgg
25141 gaggcttaag caggagaatc acttgaactc gggaggcgga ggttgcagtg agccgagatt
25201 gtgccactgc actccagcct ggtgacagag tgagactcca tctcaaaaaa aaaaaaaatt
25261 gttgagggct ctctctgcca ctctgattgt agactagggg agaacatggc ttggtcaggt
25321 atgaagtgga agaggaataa tgaaaagaac cacccaggcc tgcagtgcag gtcagatgac
25381 cctcggcctt ctttacctta ggtggcccat gagggcgacc tcagtaattt tcttgttctg
25441 aatgtccagg gtgagtctgt aagacgtttt gccctcagta gattcatcat taactctgag
25501 gattgttccg aggtcaacat caaaatccgg aatttggact tcactggaca aggtcatact
25561 ctgccgatta tatttgaatg tcatggtagc ctcagtctgc ttcgcacctg gacgagtgta
25621 taagagaatc aagagatgtg tggtaagaag ctatgttttg ggccgggtgc ggtggctcac
25681 acctgtaatc ccagcacttt gggaggccaa ggcgggcaga tcatgaggtc aggagatcaa
25741 gaccattctg gctaacatgg tgaaaccccg tctctactaa aaatacaaaa aattagccgg
25801 gcgcgttggt gggtgcctgt agtcccagct actcaggagg ctgaggcagg agaatggcat
25861 gaacccggga ggcggggctt gcagtgagcc gagatggcac cactgcactg cagcctgggc
25921 aaaagagcga gactccatct caaaaaataa ataaataaat aaataaataa ataaacaaac
25981 aaataaataa ataaataaat aaagaagcta tgttttggaa ggaaagagag gaaaaggtag
26041 agaaactcca aggaatcaat gtgcttaaac aaaaacacag ttcaggattt tactgaattt
26101 tttttttctc attaaaattt tttaatgggt ctcatttact gataatttta aactcagttg
26161 tgttcatgta tgcaagtctt tatggattgc ctgttatgag cctattgtgt gctgggcact
26221 gctcttggta ctggggaatc cttgctttca tggggcttac cttctagtgg gggaggtgta
26281 caggcaataa acaagtaact tgctcatgtc agatggtaat gaatgttatg aagaagagta
26341 aaactggata caaggataaa agaaagggat agaagaagtg ttatttcata cttggtggtc
26401 agagaaattc tctctgataa gggcacatgt gggcagagac cagaatgaaa agaggttgga
26461 gccacgctga gttctgggag gagcacattc caggcagaag gtcaggaatg caaaggccct
26521 gaaatgggga gcacttagct tgtttgtgga acagcaaagg ctcgcagccc ttctgggcca
26581 ggaagacacg acatctctat attactttct acccaagatg cctgtcctgg ttccttgctg
26641 cccttgccct gggctccatc tccccaactc cccctttctt tgtaacaaga ttcccgggcg
26701 tccttcaatc cataggctgg tccattttat atccttcgta aaacaatgtt taccaaacac
26761 tatttcccca gcgtgccctg ctcctccagt gctttctatc atgggatttt cttcctagtt
26821 taattctgtg atatgctatc cctatataaa aatttttcca aagtgaacac ctaaatgtgc
26881 cccattccct aaaacctgct cctcgctatc cctatataat tttttttcca aagtgaacac
26941 ctaaatttct cccattccct aaaacctgct cctccagtag ccctttccat ctcaataaat
27001 ggaagttcca tttttcagtt gcccgggcca aaaaccttag gtttgtcttc attccccttt
27061 tcctcttaca ctcaacatcc actgtatcag caaatcttgt cagcctaatc ttcaaaatat
27121 ggccagaatc catccccttc tcatatctct tctgccattg ccctgatcca aaacaacact
27181 gattcctgcc tggattattg tgataaccta catattagtt tctctgccct tgtctgccca
27241 tagtcttttc tcaacataaa cataaatcaa atcatgagga ctccccaatg gctttcgttt
27301 aattcataga aaaagccaaa gttcttacca tggcctatga gattatcctt ccttcacctc
27361 tccatatctc tctgtcctca tcttctacct cttttctccc tggtctttct gctccagcca
27421 tactgtcttc cttcctttcc ttgaaacatg gtagtagtgt gtcagcctca gggcctttgc
27481 acttgctggt ccctctgcct gttaacagtc ttaccacacg gcttctcctc ttatttctg
27541 taggtctcct tatgctcact ttaccaggga gactttccct tattattcca aatgcactgc
27601 tttccctgcc cttcttcctc cctcctactc ctagccctcc atagaccagt ctacgctctg
27661 ttttcctcct cagtacttat ctgatattcc aaatattaac ttgtttggtt gttcactgta
27721 acttccatga aggcagagac tccattgttc actgttctag ccccaggtct tagaataggc
27781 ctgccgctta ttgggtactc agttaaccca ggtcttagaa taggcctgcc gcttagtggg
27841 tactcagtta acctatttgt taaataggtt aaattacatg tcttctcctc atgaattctg
27901 aacctgagac tgcgagcaga gatgaggcag ctgtgttttg aatactcacc ttctgcttga
27961 gttacaaact tcagggtatc caccaaggct ctgtcctctc tctggagctc ataggttgcg
28021 ctgacagaat actgctcaat ctctcctgta ggcctcagtt ccagctctaa tctaaagaca
28081 ttacaatgaa gacagtgcat aatgttagag ctttcaagga tggtgattat gttcccaaaa
28141 caattcagcc tcaaatgcaa caaaaatatg gtccttattt taacattgtc tcttgccctt
28201 aactaagatg atctttttga tccctcagtc ctacaagaac ccaaggcaag ggcagacacc
28261 aggattccca agactttgga caagcagagc aggagttggc tggttgtttc agcaaagctg
28321 agaacaagca ctggaacttg ggggctgaag acagggagcc acctaagtac ggtgaaggct
28381 tcaagcacat tggtgggctc caggaagctc atagcgatgg gtctggaggc tcagaaacat
28441 ggacactgaa ttaggagcaa attgggatct gtgctgtgat cccatcccat gcacaaggaa
28501 gcaaaaggtg acacccaatg tgttggccag aggaccctgc tttaaatacc caaagatggt
28561 gcaaacccag aaggctagtg acagggtctt acaacacaga gtattttttc ctgtgccatg
28621 ctaggtggcc atgatgtgga aggtgagaaa atgctgggtc aggcactgag catctctaac
28681 ctggtgtccc cggtcagcgg atagtaggag gcggagtctg tggagctggc gttggagtaa
28741 gcgcctgagg tgcagtaatt caggccagga aagacttgct tgcaaactga ccaggactgc 28801 ctgttctcaa tgagaggtgg gatcacctcc gttttggtgg tagagaccaa atgtaatgtg
28861 ttgctggtga agaacaaaaa tacctgagtt attgccaagt catgaatcaa aatggacatc
28921 acaaattctc agggtgcaaa taccccctta tcctcctgtc ttccctcagt ccacacctat
28981 ctctaactat ttaatttact gagaaacaaa taatattaga aagaacatca acatgacaag
29041 ccatgagagt gactctgaag cttctggctg agttctttcc atctgttacc tgtaatcccc
29101 acaacagtag gcttatggtt ctcattttac agaagcagag gctcagagat gttaaatagc
29161 tgatcactgg ggctgaactt cagtgtgccc cttccttcct acaatgcagg gcaagagaaa
29221 ctgtctcttt catatgaaat ctcctactct ctacctgctt ccttccacct gcattaagca
29281 cgctcaagtc tcttcccctg tgcccctccc ctatgctcct ttctttcttt tcttgctttc
29341 tcatcttcct caccatcaag agttgtctgc ctt tgcagtc tctacttcct cccaatgtgc
29401 tctgactgct cactccatct cctgaaaatg ctt tcatcaa tgtctctaat gccctccttg
29461 ctcctacatc caatgggcat atttaggttt catcttcctt gacctcccag aagccttcca
29521 tagagttgcg cactcatgac cagactaaga cgctggagcc tctcacatct gaagagatga
29581 tggcaccttc cttccaagtg tgtacttaaa aacttagtac atgtaagaaa gttcaacatt
29641 ggcctggttt tttctaagga tgctttcttt gaaatagcac attttcctcc aagtattgtt
29701 tctccaagtt gggggtgcca caagaccaag ctttgctgat gtgctggagt cctaatgcca
29761 gctttcgcct acccatgggg tgatctcccc tgtggctgct ctttggcttc tgtgaccttt
29821 tatggctttg gttctccttc tgcttctctg gtcacttctt ctaactcatt gctggttatt
29881 ccccttcttc ctttatatgt ttgtcttctc catatttctg tcctcatctc tcatgtctca
29941 ctctatacca gttgctgttt aaccacaaca acctctgtat actaatgatt cccaaatcca
30001 tatgtggagc ccaagcctct ttactgggct cagatccata ggtctatttg acagctagat
30061 ttctaaactg gttgtttcat aggaggacat caaatacagc acatccaaaa ctgaatttgt
30121 cactttcctt gaaaccagaa gctctcccac tgtagttctt attaaaatga agggcgcctc
30181 cttcctcttt tcttctttct tttgccttgt ccccataccc agttaatcac ccagtactta
30241 tgattctgcc tcttagaaag ttgtagaatc tgctcactcc tttctatacc tggcttttct
30301 ccactgcagg ccattatcag ctcttagcca cataggatcg taagagatgt ccaatggtct
30361 cttcgtgtcc agctgtgcct ccttctcacc catcttccac actagagtca gagtatttct
30421 tctaaaacat cacccctatc ttatttctgc tccccttttc aactcctgtg ccttcaaaag
30481 agtccaaact ccttaggatg gctttcgcag ctgggcatgc tctctcccct gcctacctct
30541 ccccatcatc tctgagcccc ttaccattct gcacttcttc cagttccttg aaccatattc
30601 ctttaccttc aggccattac atgcttttcc ttttgcctgg aacactcact cctttctcct
30661 ttgcctaaat gactctgaca cagtcctcag ttatcaggtc aagtacactt gcttcagaat
30721 gcattccctg actagcacag gctacatgat ataaaatttc atggtactct aatactttct
30781 ataacttagc ccttactcta tgattactgc ttgcttaatt gtgtgtctcc cttataaaat
30841 gtaagYgttc aaaggtcagg gaccttgtgt gtctcactca acatacgtgg tatatattag
30901 gcaattaaat atactatttt ttgttttttg tgagacagga tcttgctctg tctcccaggc
30961 tggagtgcag tggtgcaagc atggttcact gaaggcttga actcttgggc tcagttgatc
31021 ctcccatctc agccttctga gtagctggag ctacaggcat gtgccaccac gactggctaa
31081 ttttgttatt tatttaattt tttttgtaga gatggggttt tgccatgttg cccaggctgg
31141 tatccaaaca ccagggctca agcgatccat ccacctgggg ctcccaaagt gctaggatta
31201 caggcatgaa ccaccgtggc tggccaatta aatattattt ttgaatgaac acatgaatgt
31261 gtctaaaata tgaaaactaa ggcaaatcaa tggttgaggg tgccacttaa aatggaactc
31321 tccaaaagag gctgtattcc attatcacga ggttaggagt ttcatgcttt acctacctag
31381 ctacctcaaa tcaatatgtt cttaggtatt tt tKggggg gaaaatatta attttccaaa
31441 gatgatctct ccRgagctat tgtttcttca ttctcaaaac aaatagataa caaaaaatca
31501 caacttaata aaaactaatt aagcagtagg tcttaataag tctcaaagca gaaagataaa
31561 ggacagttta gtaaaatgtg aaaagtagaa gaaaggtaat tatgtagtta tgtagtaagt
31621 ctaggctaga attaaaatag gtaacccgga atctttcctt tctactcctc tcctgcttcc
31681 tcaggacctg aatgatctca atcaactgtt tagcctggca aaattctgca ggtacattct
31741 ctgttctctc tttcaaactg gctaggcaga cttggctgaa agaattaccc tccactgagc
31801 agcttgactg gtctctttgg ggaaggaatg ataaacttca gcttcccagc ttttagggca
31861 acatgagcct ccagacccga ctcgtggaag aagttggtRt tcatctggac cccactccta
31921 gcgaagtccg gaatgatgat gcccatattt gtcacaaact ccacagacac ggagggtttt
31981 gccaccagtt cagcctgcat ctataagtca gaaaacaacc tattcagatt cattaaatac
32041 ttcagtcccc tgtcagtcag atcaaccacc ctttctcacc tccgggcaaa gatttcctgg
32101 ataactcaga cctttggaaa cattactggg atttgtttgg aagaaggaaa gcgagttctc
32161 agttctctag agttggagta tactacccag aactagaaag cacctgagtt aacgtgaggc
32221 aaaaccagat taaaaagatg ataggaatac tcatttgttg agagaactga gttcttgtct
32281 tatggccata ccactactgg agctagtgag gtagtgcatt ctggtggaag cttgaagttt
32341 ttcataaaaa aataatgagg tgattacaat gatgaagcat tttgtcttga agtggaaaca
32401 catttttaaa tatgttttaa caagaaatgc accctggaag aaagtaataa cctaagaaat
32461 caaaaggcaa acagaatctt acgttggcta cttccagttt tactccagcc ttggctccgg
32521 gagcaatgac tccagatgaa gatatttgca actgtaatcc agctccagtg gggagttcaa
32581 aggcattctc catgaagatg tagtgaagaa aaaagtcatt ctttgagccc ttcctgatga
32641 cctctccaat ctgtagaccc aacaagggag agcaaataaa agtaagtctt tttaaagtcg 32701 gttttgttaa ttacaacctc ccatacattg gagagtaatt cctctttatc tggaaaggaa
32761 ggactagcat attttgatga gctgaatagt ttgataaata aagatcaaac tgatgttttt
32821 accgttttca gtgaatcagg atataagaaa tttcactaga tagatatcat gtcattttca
32881 agtggactca gaaggctctt aagaatattg ctgggcctca gagctttatg gactttaagt
32941 atcatatatg ccatggctta attctggtgt tctggagtct gactgtaagt gaaggtgtac
33001 ttgaaatgta ttatattatg ataaaatcaa ttttttgaaa ccaaaggcct attgagatga
33061 tgtacatatc aatttgcatt gggttttatt ttttaaataa tatttcaata aaatagcttg
33121 agacctgttt tcttaaagtc aacatttttt taatcaagcc ataggagtac atttatatat
33181 ttccttttat gaattaataa taaaaattat agcatattta gatagtgaat tatagtttgc
33241 caaatacttt cttttataat cattgtatca tttcaatctt aaaaggacct tcaggtcagg
33301 tgcagtggct cacacctgtt attccagcac tgtgggaggc ccaggctgga ggatcacttg
33361 aggtcaggag ttcgaaacca gcctgacatg gttgtcaaca ggcttgtctc tactaaagat
33421 acacaaatta gccgggcatg ctggtgcacg tccacagtcc cagctacttg ggaggctgag
33481 gcaggagaat tgcttgaacc cggaaggcag agttgcagtg agccgagatt gtatcactgc
33541 actccagcct gggagcaaga ctccatctca aaaaattaaa aaaataaaaa taaaaataaa
33601 aggaccttca gcaaaggtag aggaaggtat accgaacatt gttttccaga tgaataaatt
33661 aatgctctta aaaatacagc taacattatg aatagcttaa tttctaaatg ttaacatttc
33721 catgtgatcc aagagtcatc ttcagtgaaa ttcaaggcaa acctccatct ctgaagaaag
33781 tacaagcatc ttttcgggct tgtgcagctg ggatcgtaag ggagtctggg cgatctaaaa
33841 aaaaaccaac gtctggtctc atgggccccc agtggggcct gctgacttac catctggggg
33901 atcccctgca gagtgcgggc acccatcaga agcagctttc ccaggagσtg gaggtcatgg
33961 agactggcaa aaccaagctc ctctcccaag atgcggaggt aggctctggc ttccgggact
34021 tctttggatt tcaaatcttt aatcagcttc tcaacactga gcattattcc atttaccata
34081 tcctgagagt ttagtaataa aatggccagt gagatgtcag caatgtcaaa cacctttcag
34141 ttcccaatgt gggacctgtc tgatgcagcc aggatgggcc taaaaaatgc tccaggtgag
34201 gaacagggag acactgaagt ccaggctaat tcctctaagc agagattaaa gaactaaggt
34261 cttgtcaggg atagtggcac tcctaaagct attcttaatt aaaaaatctg tagacatagt
34321 aagatgtggt gggatgagag gaggggtccc tattctccag tatgccagga tcctcaagat
34381 tagaagatcc tctatccccc acccgttccc tgcttagcct tctcttcttt gaccagtgaa
34441 gactacaagg tgtttcttaa gaaaatgtag ctgttatata aattcaccag aagtttgaaa
34501 aacacttgat cctagacaag ttcttctcag agagaagaag aatctcagag atggatgccc
34561 aggcattggg aaaaaaaaaa tgtgaaactg acagactcaa agcagatcaa agatcctcgg
34621 cctcaagtgg gggtcaggaa attagaagat ggagctcgtg ctcaacagtg agcctggagg
34681 ggtaaattac tgccttgctc tgcaaagttg aatgtgcata caagtcacat gaggtcttgc
34741 taaaatgcgc ttctgattca gtagattgtg ggtgaagcat gagaagctgt atttctgacc
34801 agaccacact ttgggtagca aaaaattcaa gaataagctc cagatcatac aacctatttc
34861 cctccttaaa tgggggctca ttgctagctt caaagtggaa gtttggtctc atttgctagt
34921 gcactgatgg gagtgagagc caaagacagc agttaataat aatgaaaata ttaatttaga
34981 actcgtaata gtgtctgctt attgaacaac caatgccagc atcaggcact gtgcttggca
35041 ttttagatgc cttatttcat tgtctttaaa taaccttgtg aggtttggac tgttattagt
35101 agtctgggat acagacagaa acagatacac ataatatcaa ccaacttccc caagtgcgca
35161 cagcttcaag acagggaagt tagaattaaa tctatgccca gagttcatac tttttttttt
35221 tttaagatac agtctcacac tgtcacccgg gctggagtgt aacggcgtga tctcggctca
35281 ctgcaacctc cacctcccgg gttcaagcaa ttctcctgtc tcagcctccc gagtagctag
35341 gattacaggc acccactacc atgcccagct agtttttttg tatttttagt agagacgggg
35401 tttcagtatg ttggccaggc tggtctcaaa ttcctgacct tgtgatctgc ccaccttggc
35461 ctcccaaagt gctgggatta caggcatgaa ccaccacacc cagcccagag ttcatactct
35521 tgttatccta gagtacttat tgtgagtctg gtttctgggc acactgaatt caggagatct
35581 ttaactgcag aggatactgg cccttacccc agcaggtctg gttgataaaa accatagtta
35641 tcccttcagt tagatagtat tttgaggact tccatgctta gaaaagaatt gtttttgcat
35701 tgagacccaa agctttcctt aagaagatac ttcacaaata cacacctgct catgtttatc
35761 atctttggta tagccaaagt ggtccactaa gaccttagag acaccatcag gaacttgacc
35821 attaacccag tacaaagctt tgttgacact gtctgggaaa aatccttgct tcccaaaaag
35881 agcttccaat gttggctcaa agccttttcc ttccaagcca atctgagaaa gaaaatcaga
35941 caagaaaatg gcatcaggtt tctttgttgt atgccagcct agtagtcccc actcttgatg
36001 tccatttatc taaacaagta tttgaatacc acaggccagg agctgacctt agcatttcac
36061 aggagctgct ttattaaaat ctcactagaa tcttgacctt attacttgct tttttctaga
36121 agaggcagct aaggttcaga taggacaaat aattcaacaa aggattcaga gttgggagtg
36181 atttgagatt tgaagcagat ctgactaggc agcacatatg cttccttggc tttgggactt
36241 aaagacgaga catttgcatt tcaatttttt tttttttttt tttttttgag atggagtctt
36301 gctctgtcgc ccaggctgga gcgcagtggc gcaatctctc ggctcactgc aagctcagcc
36361 tcctgggttc acgccattct cctgcctcat cctcccaagt agctgggact acaggtgcct
36421 gccaccacgc ccggctaatt ttttgtattt ttagtagaga tgggctttca ccgtgttagc
36481 caggatggtg tcgatatcct gacctcatga tccacccgcc tcggcctccc aaagtgctgg
36541 gattacagga gtgagccacc tcgccaggcc tgcatttcta ttaatgttaa gaagtcatgc 36601 ttcaggtgac ccctagcggg gagagaggaa ggcggggaag gagggaaaga agaaagcctc
36661 agaatcatgg taggaagtgc ctggtggttc ttagttttcc tctgggtagc tcctggctcc
36721 cagggactct ctgtttatga tgctgtacaa aatgggctag agaacctcaa actcttcaca
36781 cttacctcga tgaggtcagc tgaagcaaat ccaaaggcag tgagggtagt tttcagcatg
36841 ctttctttag gaaggtagtt atttggatca aatataagat tcccttctat tttggctgag
36901 gctgggtcaa gtgatggaag agaaacagat ttgtagagtt gatagttccg agagaatttt
36961 ctgaagtcca tgacagttgg aagttgagat tctttcagaR cttctttcac taactttttc
37021 agactagata agaagaagta tattttgagc tgacacacca tgttattatc ctttgactct
37081 tgcaccccaa gtaaatatgg atttccaatc actaccaaaa tgtcttgatt tcattgaccc
37141 taagtctttg ggtctagatc tgctacacat ttgcacaagt gtttgtttca gaagcaaggg
37201 cagacagtgg ctatgccaaa acctagggtt ggaattccag ctcagggccc tcagtggtat
37261 atggggtgaa tagctcttac ttactcttgg atatccaatt cttctgagtt caagatattg
37321 gcaatatggg aagccacaaa gttcttcact tgctcattct gttcccatgg tagaatttgg
37381 acaattttgt taatatctgc ctgtgaagga ctcctcatca acataagata ggcagccagt
37441 cgcttatctc ccggagaagc atcatcaagg aaagtctgaa gaagaacctc ctggtcctgc
37501 agtcaaaaga ggagatggtt atcactgtcc tgtggtcaga acacagaaca tgcctggcaa
37561 acactggcat tgtctgctag ctctttctta agcacaggtc taatttctct gtaatcgttc
37621 ttcaaatgct ggtattgaat cttcttgcca gtgtttccta gagcactatc aagtaagggt
37681 tcccagaaaa agcctgtgga atgcctgttg aattcaattc cattaaaaca cataaattat
37741 ggccaagttg tgatttgttt ggagatccac cactaagtga aaatcaagtt gttttaacgt
37801 aagttatttt aatgtgagga taaagatgag aaggggtagt aagagtttgg ggctaataaa
37861 tagggtagtt tccaaagttc tggagtcttt gcacctaaga gggggccaag ttggctatcc
37921 tagcctaagc ttattggggg aaaattaagc atgtttttcc atgatgagag ggatggtcaa
37981 tctggtaggt ggacggtagg aagcaaaaac atctcacgtt ctgcatgttg acatagcagc
38041 aaagtcaagt atttctctca cgtcacatac tgctaggcag tcaagtcaat aggcttgttg
38101 aaatttgcaa ttagaaaaca gtagaggcca ggtgcagtgg ctcacgcctg taatcccagc
38161 actttgcaag gctgaggcag gcggatcacc tgaggtcagg agctcaagac cagcctggcc
38221 aacatggcaa aactccatct ctactaaaaa atacaaaaat tagctgggtg taatggcaca
38281 tgcctgtaat cccagttact caggaggctg aggcagagag aattgcttga acccaggagg
38341 cagaagttgc agtgagccga gatcatgcca ctgcactcca gcctgggcaa tagagtgaga
38401 ttccatctcg aaagaaggaa ggaaggaagg aaagaagaaa gggagggagg gaggaaggaa
38461 ggaaggaagg aaggaaggaa aggaaagaaa cagcagaata aagtcagtag atgaaatcta
38521 gagtctcatt cccctagtac cttccaaatc cttgttaata aactttcact ttcagacctc
38581 ttcttgtgga ctttaccttg tctttaggct ccattttccg cagagcctgg atggcagctt
38641 tctggatcat cagtgatggc tttgtacttt ggacacattt Saggattgaa gacttgagtt
38701 ctggagttaa ctgctccatg gtttggccca tatttccaat gacctgcatt gaagaaaaga
38761 aacaagaacc catcagggtg caggagaggg aagtaaaagg tgtccaggaa aagtgcttct
38821 gaaatgatgt atgtcatata aaagactgag attacccgca gaatcaaata ggtgtaatct
38881 tcatccccag tgcagtcatc ttgaatctgt tccatcaggt aattagcaat gtccagcagc
38941 tcctgggtcc ctgtagggtt tgtcttatga tagctacaga ataagagaag agagtcagga
39001 cttggtaacc ccagttaggt ttgtcttaaa acccaaactt gtgaattaga aaaaataatt
39061 ataaaattca tatggaatcc aaaaagagcc tgaatagctg aagcaatttt aagcaaaaag
39121 aacatagctg gaggcatcac attacctgac ttcagattat acaacaaggc tatagtaatc
39181 taaacagcat ggtactggca taaaaataga cacatagatc aatggaacag aatactgaac
39241 ccagaaataa agtcacatac ttacagtcaa cggatctttg acaaaaYtga caaaaacata
39301 cactagggaa aggacaccct tttcaataag tggtgctggg aaagatggat tgccatatgc
39361 agaagaataa aactggactc ctatctgtca ccatataaaa aaatcaactc aagatggatc
39421 aaagacttaa atataagacc tgagactata aaaatgcaag aagaaaacct agggaaaact
39481 tctctggaca ttggcctaga caaagaattc gtgaataaga cctcaaaggc aaagacaaca
39541 aaaacaaaaa atagacaaat agaacttaat taaagtaaaa agtttctgca cagtaaaaca
39601 aataatcaac agggtggtaa cctgcagaat gggagaaaat atttgcaaac tattcatcca
39661 atggggtact aatatccgga atgtacaagc aattcaaaca actcaacaaa aaaatccccc
39721 aaataatccc attaaaaagt aggcaaagga catgaataga catttttttc aaaagaagac
39781 atacaaatgg caataggcat atgaaaaaat gcataacatt actaatcatt agagaaatgt
39841 aaattaaaac cacaatgaga taacatctta caagagtcag gagggccatt attcaaaaga
39901 caaaaaataa cagttgttgg tgaggataca gagaaaagga aacagttaat cactgttgat
39961 gggattgtaa ataagtacaa ccactatgga aaacaataca gagatttctc aaagaactaa
40021 aaatagaact accaataaat ccaacaatcc cattactggg tatataccta aaggaaaaga
40081 aatcattata tccaaaggaa acctgcaccc atatgtttat cacagcacta ttcacaatag
40141 caaagacatg gaatcaacct aagtgtctat caatggacga ttggattaaa aatgtgaaat
40201 gtataggcaa taaaatacta ttcggccata aaaagaataa aatcatgtca tttgcagcaa
40261 catggatgga actggaggtc attgtcttaa gtgaaacagg acagtcacag aaagacaaat
40321 attgcgtgtt gtcatttata agtgggagtg aaataatgtg cacacaagga catagtgtgt
40381 ggaatgatag acaattgaga ctcagaaggt gtggaagtgg agggagatgg atggtgagaa
40441 attacttagt gggtacacta tatgttgtct gggtgatgga taccctgaaa gccctgactt 40501 aactactgca caatctattc atgtaacaaa attacacttg ttccacataa atttatataa
40561 aaatgtaaaa aagaaaaagc caaaaaattt catcaaagga aaaacctgct agcctgagca
40621 acatggtgaa accctgtatc taccaagaat acaaaaatta gccagggcat ggtagcatgc
40681 acctgtggtc ccagctactc aggaggctga ggtgggagga tcacttcagc ccaggaattt
40741 gaggcttcag tgagccgtga ctgcatcact gcactccagc ctgggtgaca cagtgagacc
40801 atctcaaaaa aacaacaaca acaaaaaaaa acaaaacaaa caaacaaaaa aattcagagg
40861 aaaaaactgc taactaatat tgaactgaag ttaataatat gcaagctgta atacttaggg
40921 gaaagtgtgt tgatgtttgc aatttacttt gaaatgcttc agaaaataag atgaattaat
40981 ggatggatgt atatgtgata aagcaaatat aataacactt aaatagtagg agatagctgg
41041 ttttctaggg gttttccctg tgaaattctg tcaactttgc tatgttcaaa aacttttata
41101 atataatgta gagaaaatat ttttaaaaat tcaatttgtg tttgctgatt tcttatttca
41161 agtcattacc ccaaaaatga tcaagaaaaa acacaagagt aaggagcaga gtttgaaagt
41221 ggaaggaggg gttcagtttt aatacagaga tgcacagagg tgcaagatgt tcctctgctc
41281 ctaggaggag aaatacagtg tggaaactca cttgttgacc gcgtggctca gcgcatacaa
41341 ggtggctcgg ctgcgctgat ccctcgccat gttgaagatc tctcgcagct gctgtgctga
41401 gggctcgggg atcagggcca ccaggtaggt gaccacatct atcagaaggg ggttggcatg
41461 cacacgtttc agccactgga ggatgtgagt ggagcactga ggctgtccac actgaaccaa
41521 ggcttgtaaa gtgatggggc tgagaagaaa gacatggata aagttataca gaccaccttc
41581 agggcacata aaatattgct catggtgtgt cctctgccag gagagccctt aatcacctca
41641 ttcactattc aaatctaact tcaaaaccca acttggagct cagaaccatg atgctttcct
41701 taggaatatt acccacagaa gaagcccaat cgagaaaagt tccaagaggg gactgtggat
41761 ctgtagcaac aagaagactg ttatcacagt cctttggcca gcacacagaa tatgcctggc
41821 caacattagc tgggtctcat tcctggcctc agtcccttct ctcaccttca tagcacttaa
41881 agccagtgcc ttgaagggta gagaaatcat attatatttt tcgtctgagt tctctctcca
41941 ccagcctata agcttctgga gagcacctgc aatagaccta ggaattaaaa gttacccatc
42001 aaaatgtggg aactattctc cttctgtttt aacacacaaa tacatagctg ccttgaacac
42061 agtatgcgcg tgtgtgtttc atggaactca gcgcagcagc tgatagttct ctatccagca
42121 atcatgaact gattgactaa ttgattaact ggattgatat ccaaatggtc cctgagattc
42181 tccatttggc caaggtttga aagttcagtc agttaccatc agttttataa aaagttgagc
42241 tgtaaccatt agatacctgg acacctcaat cagctgtggc aagagagatg tgactgcttc
42301 atcactgagg cctctcagct cagtaaccag cttattgaag agattagctc tctggatatt
42361 ttgctcagag atggttagtt ttttcagttc ctggagagtc ttcaaaacag cttcggcctg
42421 ctttggaggt gatgtggatt tggtgctctc aaatgcgagg cccatcttct tagtacctgg
42481 aagatggaaa gtgtcaaagg aactctagct ttcttcatct caaccatatc tttgtctact
42541 ggaagctgga aattgtggag tatcagcaca ggggaaaagg gaaagaaact atcctgtatt
42601 caatgcctgc tagatctggc tctgccatag gtgattgact tgttttcact gactcatcat
42661 cctatccctg tggggtggca ttattgttca atttaatgat aaattcagcc ctgcttctga
42721 gacccacaga gtttttgggc catgtaaatt gctcatccct ggatctcagc tctgagtccc
42781 agagatgaga caaagagatg agacccagag atgaggaagt gtgacccaga gatgagcaac
42841 ttaggtttcc caagagctct cagggtctaa gaggtagagc taaagtggaa tccagacttg
42901 tctgagtcta tcatcaggtt acccttagct tgaaataatt ggtgaggagg gctactgtt
42961 gacatggtta caactgggac caggcacatg ggtgcttatc accatttctt ctaattgggt
43021 ctaccagcag cttgtgggga ggggagacac ttttgtatcc tctccaccac ctactgtgac
43081 ctatgccagg aagagaggta aaagtcatca tggaaatgtg gtgtaatgag aatagtcctg
43141 gcttagatta caacctggca cttattttcc cccctctaat attctgcggc cttgactaca
43201 tcaaactcta agcctctctg tgtcactgtc tcctctgtag aataggtata aaatcacatc
43261 tctaccacct gacatcacag gttgctatga gcaaaaagga caatgaggta atgtacaaga
43321 aggaatttgg acagatataa atacaataca atactgggta agggttggac ttgagattgt
43381 tagagttcct tctacctcta aagactgact cctgaggtta ctatctggcc agactctgaa
43441 ggttctctcc cacttggtcc acctcgtctg ggacagctct ggatcttatc acaggatggg
43501 tgatgtcagt tctatcaaat atgtcatgtt aaacttagga ttccagtttt ctatttacaa
43561 atgcctaagt agctttggga acttcttttc ctttatgcca ttgcaacttg acatcatgaa
43621 atgagtttgc tttctcacta gaggtagcca gaacaccagt gtctgtatca cttgttagtc
43681 agcagacatt taacagggct cagcaagtgg ctaagccatg ataggcacat cttgagtaga
43741 ttttccagca actatgtgga cagaaactct taccttcacc aaagaagcgg ctgttgatct
43801 ttggtgtgtc ttcaagtttc aaagtctgtg tcacttgtgc taccatccca tacttattcc
43861 tggtaaccaa ggaagcacac catgtcacgg atggccagaa catactattc tttccatgtt
43921 gaaggttttc cctgtctctg catctaccca agtcctgccc atctttcaaa gcatgggtaa
43981 atccagccat tgttggccct gaatgaataa catccacctc ttcctggtca cgctagttat
44041 cctcccatca aaaagacatg cgtgccttat actctccact agtctggagt ggccagaggt
44101 aggaactagt gcaatgtctc aaaattcttt cgtatcttcc acaacataga gccaagaata
44161 tggcagttac tcaatatata ttcattgatt atcagttttc aaagtggatt tggatacaca
44221 agtttccagt cagtatccca aatcttccat gaaacctttt ctaacσaggg taccctgcag
44281 tgatcctcag gttttctgga tctacagccc ttaaagaatg ggtcttagat atcttttgtt
44341 ggtcttggat tgttttgcat gcctaggact tttctgccaa atggcctgtt cgcttaaaaa 44401 gggggacagg gaggggcggc attttatccc tctccattcc tccctcccag gcacaggttt
44461 gcc tggaaca gagcacttga gaagtgttca gttcacactg acccattaaa tgacaaatca
44521 ggggtgcatc acatgaccta cttgtaggag aaaggcagga agaggtgttg ctccttgcag
44581 atgrgcttctg ccacatgctt cctcttagcg tccagtgtgt actgacagga ctggctgctg
44641 ctgatcagag ttgacaaggg gcgggtctat gaaagagatt ggagacgagc attttgatca
44701 gtccctgtat cttctgttaa aagcatttac cttcaaggta gaagggagca ggagtcctgt
44761 acσactagat aaactcagag aaagaagata actgggtact tgacatttag accagggggt
44821 gcaacaagtc ggcatcccca aagctgagtc aagctgtaga ctcctctttt tccaccctca
44881 ctggacaatg tctaaacttt gtatcctcca catgcccatc ccaccacata gcccctcaca
44941 cacctgctca gtaacttttc tttgcccaaa agcccattct tacatgtctc tttcatttac
45001 atεa-ttctttg cattttttgg gttcctgctc cacatcttcc atgaaatgtt gcccgctgag
45061 ctacatgaat aattctttct ccttcctggt caggcccagg acttcttgtc tgcactgttc
45121 agcttatcac cttattgagt ataccacgta tactttattg acctggctcc tgcattagac
45181 tggaagcatc ctgaggggaa ggtccatggt tcatctgcca ctgtcccttc cttggtgctg
45241 cccagagtgg ggttgagcaa acagcagatg ctcagaaaag acccctaagc cagtgcatta
45301 tcctcttctg actgtggcac tcatggtcat cagactccct gttttcaacc ctaaggacaa
45361 tgaccaggaa cagcgcccag catgacagtg attgcccaag ttattcatgt tcactgagac
45421 aggctggggc tcatatcagg gaagatgttg caggggtcag gcaggctcag gtaatatggt
45481 get ccatggc cccagttaac agagaggaga gggtgctcca ggccggtggc agtggggcca
45541 tgt ttggtca gggtggtact gggggtggaa ggacaagaag ctggagcact ctaagtcact
45601 ccacttcatg ggatgaggga gagggggaga acacaggtct tgggactYct tcaaaggcca
45661 gaggcttgga gctggcacaa ggagtccttg tgcagaaaag aacagaaggt ggttttgctg
45721 ccctacatcc atccccggaa ccttctcaga ggtgagtagt cattactctc aagtgatgag
45781 attagaggca gtttggtgcc agtgacagaa ggacaggagg aaagacagag ctctgggctg
45841 ggagggagga gcctgactca agccttggct caactgatcc caggccgtga agcctgggca
45901 gaccttcccg tgcctgctca gggtcctatc tctagtctgt ataaaaaaca gccagggcag
45961 gctgtcctca aaggtgccca ctagctcaaa agttctggaa ttgtattaat aagaggatgc
46021 tcσttgctgt gcacgacagt gctgacatgg gacttaccat gcctttgatg agagcaagtg
46081 ggctgatgcc tgtgcggatg ggcttgaagc gatcacactg ccccaggtct ctttcagtgg
46141 atatttctgt tgccacattg cccttcctcg tcttgacggt aaagtgagtg gagcagtttc
46201 cat acacggt atcctatgga gRaagaagat gcaaccacat gtattcaaca cgggcaacat
46261 cct tgggtac ttgggaggga tggggtgggg atcgtgaaag aaaaagcaga aggaatctag
46321 ctttgggagg gactttcttt ttcttcctat gcagagtgtg gtcttgctag tgcctggcca
46381 gcccaagttg ggagagagaa aaccagttaa aggtgggtct gcagaaaggc ctccgcaggt
46441 tgcatcggtg tcttctccca ttatggtgtc gtagagaaat tagaacacac aaaagtgctc
46501 atgggactga ggtgaaatga attctgtctc acagtgaaac ctgaaattcg taaaagagac
46561 cagcaacaga tcccattatt tttggtgttt aaaatacaca caggatttac tgtgtacacc
46621 ataacccagc aaacacaggt gaagcatcaa acaaaagcag gggtggggtg gccaggactc
46681 ctcaatRact gttttaaaat tagacccaac ctgataagcc tgcttgggat gatctgtcag
46741 tgagcctaag gggcaggagg aacctcgggc accagtattt cacgccaatc cagggcttcc
46801 tatgtaacta gtcatggagc tgactcagtg atctgctttg tatatggtag gactggtctc
46861 taacacatga agatgagttt caagggccac tgctatcagc tttctaaatc ctcaccagaa
46921 acaacacttg cttggcttct tctgtctctg ggggaaccag gagggcagaa atgatgcccc
46981 tct tgatgtt caggatgtaa gtaggttcat ctttctccgR gtaaaggaaa acctgcttcc
47041 ct ctggaat ggccagcttg agctcatacc tgtcccagag agaggatggt cacggaaatg
47101 tccttctcca ttacaacttg ctggaagtaa gctgggtggc actgaagttt cttttctcat
47161 atttttttaa ccaattgttc ttctgacatc atttatttgt aaatatagaa tatagctaca
47221 ca agacata cattttcaaa aaagtatgca catatacata agttttggtg attctttttt
47281 tttctttttt tcttttttct ttttcttttt ttgaaatgga gtctcgctcg gtcgcccggg
47341 ctggagtgca atggcgcaac ctcagctcac tgcaacctcc acctcctggg atcaagtgat
47401 tctcctgcct cagcctccgg agtagctagg actactggca tgtgccatca cacccagcta
47461 atttttgtat ttttagtaga gacagttttc accatgttgg ccaggctggt ctcaaactcc
47521 tgacctcagg tgattctccc tcctcggcct cccaaagtgc tgggactaca ggcatgagcc
47581 accaggtcca gcYgtgtttt aacttttttt gcttggctca tccagccctg ctctgttctc
47641 cacccatatc agtctctttg cccatcctcc ccatacggac acccgagtgg ttgttccatt
47701 tgtttctgca cactcataca atcctctgta aacatgggtg agtgcaaaca gagtcataca
47761 aagattttgc cattgtttgt tttatacaag tggcattgta ttatgcatac ttttatcttg
47821 tttttctcac ttaattatac ttcacaaaaa tccttctgag tcacttggta cagctctaac
47881 agattttttt aaaagctgca tgcagaacat tccattccat ggctaaatat aatttattca
47941 ca attgccc catttgatgg catttgccct ctctctttct ggattttttt taaaccacac
48001 aaacaatacc aaaacaaaca tccttatgtg cctatcttca cacattactg cttttatttt
48061 catgggctag agtcccaaag actaaaatat ctgtgtcaaa gggtattaag tattttaaat
48121 tac-agtagat attgcctgat ggctctcgtt tccaccagca gctcaggaca gcacactttt
48181 cctcactggc ctgccagcaa caggtgctat cactgttttc cagttttgca gtatgatggg
48241 taaaagcaga taaatatctt gttgttacat taattcgcat ttcttgacta ccagtgaatt 48301 ggagcttatt ttcatacact tgttggacag tcattctttt gtatggtgtc aggccatggc
48361 tgaagcccat gctgactttg cftcttaggga tttcccactg ggtactctct gagtttctga
48421 ggacctggct gcagccactc tggttacatc aggaggaaaa ggtgacggac ttatctccca
48481 cagcctacac tctctcagaa agttcccaac acRaagaaat gataaatgtt tgagatgatg
48541 ggtatgctaa ttactctgat ctgatcacca tacattacat gtatcaaaat atcactatgt
48601 tctcaataaa tatgtataat tattgtatgt caatttttaa aaaagacagt taaagtcatg
48661 aagatgcaaa catggaaagc cctccttttc aagaacagga gtctcttctg tatttggaga
48721 agaccaagga ccaaaaaata aaccactctt tcctcctgcc accatacccc tctccctcat
48781 atacagttaa gtcttggaga aaataaagca taggaaagaa agaagcctca cagcctattt
48841 tggcaagaaa ggactggcat ctgaatctaa tgtttagcaa aactgaaaaa tgggcaagga
48901 tggtgatatg gtttggctct gcgtccccac ccaaatttcg tctcgtagct ctcataattc
48961 ccacgtgttg tgggagggac ccggggggag gtgattgaat ca gggggca ggtctttccc
49021 gtgctgttct cgtgattgca gatgggtgtc gggagatctg atggttctaa aaacaggagt
49081 ttctctgcac aagctctctt tgccagccac catctacata agatgtgact tgctgtccct
49141 caccttccgc catgattgtg agacctcccc agccacgtgg aactgtgagt ccaataaacc
49201 tttcttttgt aaattgccca gtctcaggta tgtctttatc agcagcatga aaacagacta
49261 atacagacag agttttctga tgctaccaag ttaacaactc tatcctgcct gtattcatac
49321 acacctagga ccctacaaac tgtgattgag gatgaggcag gggtgatgtt gaaaatattt
49381 acaatgggtg cgacatgggc cctgaccagt cagcagagat gcagctgcag tggccgatca
49441 gcgtgcagtg gctgaatgcc agcctaggag ggggagccac cgaagccttg gtgctcctct
49501 gccctgcggt gaacagaccc tgccccgcca tgtgccggcc acagcagcca gtgcctctgg
49561 gaccccacac caaagaccac caagcactag tcttgactag ttctttaaat aagaattcac
49621 ttgtttaaac aaagcatctc agttttataa tctcaagaag tttaaagcat gagattttta
49681 gaaacacatg aaaatgataa ttaaaggaac ctaactaggg aaRgttaact aatgcttctc
49741 tctttttgat gattgtgaaa actcagtaat tccctgatcc acgatggata cggaatacaa
49801 atacttacag tcacatccgt gcctggtgca aacacacaag ttcatacctc agcggacaca
49861 cacacatgcg tgtgctcatg tacaacatga cttacctgga catggctgca gcaaactcct
49921 cagagttctt ggttttcttc agcaaggctt tgccctcagg gttgaagcca tacacctctt
49981 tcaggRtgca ctggctggtc ttcaggatga agctgcagag ctggggaacc tccagctcaa
50041 cctgagaatt cagggtagca gagcattgag gttgtctatc aagaatgaga ggtggcccct
50101 gaagcccagg gcttaatctc taatcagagc accaaaggga atggtgctgg gaacaccact
50161 gcctgcgcct caacaccaca tgccttatca acatgcctcc tgggttctct gtgcaccaac
50221 ctagacttag tcctattgct gacgttttcc ccctcccggg taacacattt cttaagtttg
50281 cccctaggca tgggaaggag gatgtccttt tattggttct aaagttactc actttaatta
50341 taaagagctg tggttaaata gaagcgctgc agactaggag tgaaagtgaa gaagaaaaac
50401 agaaagcagg aagagggcca tccttcgttt ccacagcaaa tgtctcctta atgtcaccca
50461 aaaaactggt tatatctatt agggcctatt tagagctttg catatagctg gagtttcaac
50521 ggattcctac ttattatcca gcactattca aataacttta tagaaatgtt gtacatgtgt
50581 gctgttcaat atgggagcca gtagccaggg tggctgttga gcagttgaaa tgcagctaat
50641 gtgacaacga atatgaattt ttaatttcat tccatttaaa tagcccaatg tggctcatgt
50701 ctaccatatt ggacagcaca tacaagagct acggtactct ctaaaaaaag gtgactgctc
50761 agcttgactt ctcttcccca cccaaacccc aatagcagcc tgtagatctg ctccacatgt
50821 atgtaacatg agtacaacca gtctcaataa taagcaaagt tttattttag aacaaactgt
50881 atgtttatat ttttttcttc tttccattca tttttcagca acagattctg tttgacttaa
50941 attataaaaa ctgcatttca cagtgcgatt ccgagttgcc tgcctcccat agctcaccta
51001 ctgggcctct ctcacgctga aatctacaga cccacactgc tgctaatcta gatcatggat
51061 tcctattgca tctgggaagt taacgggaaa atacttctga cttgcgaaat ttggtggggg
51121 cagaccacat ctcagcaatg tggctgactt acaaacagag gcaaagtccc agtgctttga
51181 tcagattaca acagttctgg gatgttctgc gtttgctcag tacacaccct ccgggaaggt
51241 cgcgtgttgg gcgcccgctg gaacagggct gggggaaagc tgtgggctct aggtccctcc
51301 tgcctgcatc ctccatacct tgcagttgat cctggtggca cttcttgaat cagcagtccc
51361 agggactcca ctggaactct cagcctcata gttgtatgtg tacttccgga ggtgcttgaa
51421 tcgggtcgca tcttctaacg tggggagaaa tacgtcagcc acatagcaga aatagctctc
51481 ccaaggacag ccaattctgg gcagagaggg gcagtggcat agagaattaa aaatggtaat
51541 tcaactcaaa ttatttttta attgacttta tacttaattt tcctttatag atttgacttc
51601 tccattatgt ttttgctgag gctaatgttt aaattggctg gcatgtcttg aatatctcat
51661 ctgaggcaca gggaagggag tgacaagtgt caagtaatgg ggctcagaaa atctgcatga
51721 gagaccctct ggcaaattaa gagatgacaa cattacgcaa atagtactat ctctaatgct
51781 tttttagctt gaacacgccg taattccgtg actctaagac taccaaatac ttaaggcaaa
51841 gttcattaag cattaagcgt aactaactta acaaactcct agaaaagaat ttctggaggt
51901 ttccactgta gttgagagga attttctgaa caattgaaga aaaagaacat ctgggtcctg
51961 agtccagctg cagtgatgac agacggccac tagatggcgg tgctgcccca tcagaagtcc
52021 gccccgcggc tccagcacac agggtcgcgc ttggaggcca gttcctttaa cccccagggg
52081 tcaggtaaat aggaaggggg tggaggttcg atttcttcac aaaggttaaa gtcagtattt
52141 cctcaccctc acatgcttcg aatcaatgac tagtcactga taaacaggac agtgatgttt 52201 cttcaaagtg tgcacaggcc agcggagaga. caatcccttc cctcccccgc ccccaggctg
52261 aacttttggg acagaacaga aggccaggta gaagagagtt ggcatccctt gggtgtgggc
52321 agaggctcag ggaacttgct tcctggggtc: agagcaaggc acaccacgat gccatctcag
52381 ccctgtagag tgggaggccc tcagggaccc; gggtgtagga gagtgcacgg ggctgggcgc
52441 ccttccacgc cccatgcgca gatgccttac: ttggacagac caggctgaca ttttccagca
52501 tttcctcttc tgtaagacag gagaaagaaεa. tctgtgagct tcccacgtct tcccagcggg
52561 tgctagggcc cgacaggggg accaccggca. caggtttcac ctttcaggag ggaggcaggc
52621 tccggagacc ccctcctcag cccctccatc; ccgcgccccc catcctgagc ctgcaggggc
52681 cgccagctgg tccaatcccc ccactcgccc; tggaccctgt ggctgccctc cctctggcct
52741 aggcccaggc tgccccggcc aacctcgtgc: cgccggctσc ctcccgctcc ctctgcgccc
52801 gcagagcggc cgcgcactca ccggccctgg cgcccgccag cagcagcagc agcagcgcag
52861 gcagcgccag cagcgccagc agcgcgggcc tcggcgggtc catcgccagc tgcggtgggg
52921 cggctcctgg gctgcggcct ggcctcggcc: tcgcggccct ggctggctgg gcgggctcct
52981 cagcggcagc aaccgagaag ggcactcagc cccgcagStc ccggtgggaa tgcgcggccg
53041 gcgcccgcac cccatttata ggaagcccag gctgcaagag cgccaggatt gcaaaaggtc
53101 caaagggcgc ctcccgggcc tgacctgttt gcttttctac actggcttct ctttgagcct
53161 tgaagagcct cggggagggg gcccacctgcj gatgcagccg cagccaccag gggctgggtc
53221 ccaggtgggt tcccttcccc aagcgtcttc: agtgctctgg cgcggccctt cctgtgtctc
53281 agtggggcca tggccRgcgc ctcagggtct gagaagcctg ccctgaccag gggtgccttc
53341 ttcagatgac ccaccatggg gacaaaatct ctgcttctcc tggactgaat tgggagccac
53401 gaggagaacc agtcctgagc gctgtcttgg tggagacgtg ttcccatcgg ttacttcttt
53461 tccattttgg tggaccttgg atttgcaccc: acaccctaat cctgatcaga atctgtggct
53521 gcggggttca gcccgtgctg ggggagRagεa gagaaggggg atgcagggag gtctggtgag
53581 tgaccagtca ctgcccctga ggatgggtgg cctgcctggt cccagcagga gtccaagtat
53641 ctgtcttcaa gaaaccccag cgaggagagg cctctgggga agagcaacct ccgagggcgc
53701 acccctcttg tgcaaagtgt tcttgggttg ttgagaggag gatttcctgc accagcttct
53761 aggtttcctc cagtggtggg gaggcggacg aggaaaagca gagtagtgga caggacacgt
53821 catgttcctc atagacatct ggaaccttct catgcatcgt ttccttctct tctaggcact
53881 gcccatttcc caccggaaRc ttcagccagc- gctcgMtgcc tctgcccagc tgKagggaat
53941 cagcggtagt ggaatttcag ggacactcgcg tttactaacc caggatcact cagaaggggt
54001 tattgatggg atggcactat gatgagctga. gtgaatgtct gagcctggct gtgtccccaa
54061 ggcacctcca ctctggttag ggagacaagc: tgtgtacgca ggaaaccgct agtgagcaat
54121 tgtggtagga tagagggggc gacaaccagg taggtataac tgctggggga ccacccagga
54181 aggcgagtgg gaggcggcca ggagcaagcc ggtagagtgc ggatgggaag tggacagcgc
54241 ctgttgcaga agtcagtgtg tgctcattgt tacaacttgt cagctttgtt tgaattatga
54301 gataMcccca gatgtaacaa gctactggtg aagactgatg attccagaag gatcaattct
54361 gaaacagtaa ctatgtataa agacccagtt ccctcagagg agactcacag aaagaccttc
54421 gcctgcttcc tgcacctggg ctccacacct gtccttattc agatattgtc attagccatg
54481 aactcctatg ggcagctaaa ctccctccag tgatcagttg ctcatccaca gcatattaat
54541 gttattaaag atggatatta cagaggtctc aactcaaggc tggtcatacc tacaccactg
54601 atttgtgaaa ggtctggaaa aagtaattgc tctgaaaccc catttctctg aacactttat
54661 ttgaattatt ctatgtggac tgactttcca cagggttcgc tgctgctagt gtttgaggaa
54721 atggtcctgc ttccatgcat attcacatta aggagagtga gtaagaatat tcaggtatag
54781 agaagccaaa aggaggtgtc gagctttaat ttacaagcac aagtccaagc ttactctgtt
54841 acgtgcagat gaaaccaggg tccaatggtc agcatccata gagaatatat acatatatat
54901 atatattttt ttttttaatt tatttatttg agatggagtc tccctctgtc acccaggctg
54961 gagtgtagtg gtacaatctc ggctcactgc aacctctgcc tcccgggttt aagcgattct
55021 cctgccttag cctcccaagt aactgagat-a acaggtgagt gccactatgc ccagctaatt
55081 tttgtatttt tagtagagac ggtgtttcac catgttgatc aggctggtct tgaactcctg
55141 acctcatgat ctgcccgcct tggcctccca aagtgctggg agaatgtaat ttttatgaag
55201 taggaatcaa aaatgaattt gatgacttgg aggcagggaa acattgtgag atgcttggag
55261 gtggtgagag gactgtcacc atctctaaag gaagaaacct aagactcagc ttccctcttt
55321 tcctga ggt ctttggcaag tcttccctga actgggcccc agccagcagt agttatcccc
55381 tgacagggtc tagcacaacc ccacagagca aatgttgaat tgttgagctg acttgcgtac
55441 actcacggaa atgctgtaaa gattagtgca tagatttttc ttcaattaca aaatccactt
55501 agatcctttg tcaaagacta catggaaata cattacttgt gaccaaagat atcacccttc
55561 atcccttttc ctttagatag agacacatt c tggtgtcaca cagattaatc tcagctagtg
55621 actgtgactt atcagctcat aaatgcaaag tcctgttggg tgcaccatca atctgggtag
55681 tcatagggct ctgggtaccc attagaaagc cacctgacta gaggaatttc aaggcgatag
55741 ataatgctga atgtcccagt tacattatc t agaagcaaaa ctatccattg tgcctatctg
55801 cagccgacca gaagggtctt ggccaagttc agggaatcat ggaagctaat aaaggacccc
55861 agcagaccaa tattctgagt ttagtgctgt tcacRtactg aagtaggtgc ttagaacata
55921 atttgctgaa tatgaatgaa tgaatctgca ccattcagct ataccccatt ttccaggata
55981 tttatgcata gcgaccgtga tgcttaaata aatatttcca gtgacataaa gcaaggaaat
56041 acagtctata ccaattattc ccagccatgc tgctccaaaa tctcatctgg caaataggga 56101 tcagtattga caacgattaa ttagcctatc tcgtttctgc ctRtgacagc attataattg
56161 caaatgatgc ccagaagctg gaaagtaaac ttcaaacatt gtagatggaa ctgtgcccag
56221 ggtggcctgt ttacccagtg acagcatgca -fcgtgtgagca cgtgcacaca cacacacaca
56281 cacacacaca cacaaatgag aactatcagg -aaagaaatgg cacatttagg tgaatggttc
56341 aggaggaaga tgatagggtg agccattgtc aaccaaatgt aggcattcca gatggatgat
56401 taacccctgc gagaagcaaa aagaaacttt ccttctccat cattctgcta cccaagagat
56461 aaggtcagaa tgttgagtcg cagttcctcc cgggagagaa gccagaagtc agcagggttc
56521 aatgtgcagt gaggagctgc gtaagtgaat -fcatcaccctc ttgcctatgt ggatgtcatc
56581 cttccaccca cccagggctg gctgcagccc cacctactgc actgaatctt tctctgggaM
56641 cagcccagtt agacttcata gcttgtgact ctgattccct gtcattcagt ttctaggtag
56701 gacaacgatg atgaaaggcc ttcatacaaa cctgttgttg tcctgaatac atttttctct
56761 tatagcatta tttgattttt catgtgttta cctgttgcct tgccaatggg agagagaagc
56821 tgggagagca agaaccatgt gtagttcaca cgattggtacc ccttgtcctc tcttcctcac
56881 tgacaccctt gctaggccag gcagatggta gtcaagcagt aaacactgtg attataatgt
56941 aatatggtcc atgtgaatag gtttctttca -tatgcacact tcatttttac tcttgagtgt
57001 tgctgcttat gtttacatct tcatttagaa tgcacagtga acttggagct gtaggagaga
57061 ggaagggtct gggaactggg gccatgggac agtttctacg gctctgggtg gcagtccctc
57121 atctgtgtga tgagaagaca ggaatggacg gtctcttagc cccattcagc tctgactact
57181 ttgattctat ggaaattttg gggctgaaaa aacaaacaca taaattattt tgggctcaaa
57241 cctcatggct attaggagct gtggctgagg atccagaacc atcaagcagg aaggatttta
57301 tgggaggcca tcgacctctc caaagacctg tgcccacact gcccaagaaa tagaaccctt
57361 cactcatttt acacagattt ctaaatcaga tgtgggcatg ccctcctgag gatgctgggg
57421 cacagggaat tgcaactctc cggaagttct tccccacgtc tagctttagg tttcatattt
57481 gcctgacctt gggtaaactt tcttagatat aacttagcat ttcttttgaa aggcttttgg
57541 tcagcttttg tcagccactt tttactactt ttaaaaaaag ttttctttat gttctctcaa
57601 gactaaggct cagaacgtgt tacctcagaa agctgagacc agtgctggtg ccggatagct
57661 ggatggataa acacacctca ctattcccac accagcacta cttctcttca tgtattatgg
57721 agcacctccg agagcttcca gaccaggaga agggcataat cagacgtcac agccaataat
57781 gagcgtacgc aatgtgccca gtgtggggtc tacaccacag ttagactata gtggtacgat
57841 gggggtctcg ggggtcctgg atgggtgaga ttgaactggc tctggaatgg tgggcaggat
57901 ttgggtaact gaagagggag gcacactgaa agtgcagtgg caggaagctg ggaacatgtt
57961 ggatatgtct ggcccctgtg atgacgccag gctactggag tctctgggga gaagggagac
58021 agggggatgg tcagtggggg atacagtttg ccatgcccag gccagggaca gagctttcag
58081 gctaatgaag cctttgactt aatttgacac taaatgtagt acatatggca ctgaaactct
58141 ggattgtgta gaaggccatg agaattgggc tgaattctcc ttgttcagag ctatgaaggg
58201 aaatgtagca acaggtatct gtagtctcaa acatagacag gatcttagaa accaaatcgt
58261 gactaatatt ctcatcttat agagaaactg gggtctagac aggctaagaa gttttgtttt
58321 gttttgtttt gttttcatga caagagcaga ggtaaggcga gaacttggat ctttagttta
58381 taatctaggt tattcattct actctaattg cactaaatct acattggcta cataaaattg
58441 cttggagatt gctctttggg ccaggcatgg tgcctcgtgc ctgtaRttcc agcactttgg
58501 aaggccgagg cgggtgtgga taacctgagg tcaggagttc aagaccagcc tggccaacat
58561 ggtgaaaacc catctctgct aaaaatacaa aaattagcca ggcatggtgg cctgcacctg
58621 taatcccagc tactcgggac attgaagcag gagaatcgct tgaacccagg agacggaggt
58681 tgcagtgagc cgagattgtg ccattgcact ccagcctagg tgacagagcc agactccacc
58741 taaaaaaaaa aaaaaaaaag aagaatcttt gaaatcagtg tattctcttg tgtattagtc
58801 tgttttcaca ctgctgtgaa gaaatacccg agactgggta atctataaag gaaagaggtt
58861 taattgattt acagttccac atggctgggg gaggcctcag gaaacttgca atcatggcat
58921 aaggttaagg agaagcaaag acctgcttta catggcagca ggagagagac gagtgaggag
58981 cgaaggggaa agagcccctt ataaaaccat cagatctcgt gagaactcac tcactgtcac
59041 aagaatagca tgggggaaac cacccccatg atccaatctc ctcccaccag gtccctccct
59101 aaacatgtgg ggattatggg gattacaatt caagatgaga tctgggaggg gacacagcca
59161 aaccatatca tcttgtaatc tattccttat tgaaagtgaa aaatttcatt gatttttttg
59221 tgggtttgta tttagaataa atatgattat gtaactcatt acataggatc atagaggttc
59281 agggcctaga agggccataa ggttattgaa tccaactctt ctccatcaat ctgagaatcc
59341 ctgggcaccc attaacaggc tgcctaactg gtggaatttt atgaaattag atcatgttct
59401 aggcagcatg cagtgaagag tttctagaag ggaaacctct ccagcctgtc tatctacaga
59461 tggccagatg gagcctgcac atgtggatca gtgctttgtg gtcatatctc aggtctctgc
59521 tatttctgtc cccaatccgg ggcatagact gtccatcaca gggaaagcca ggaatKgtca
59581 gtactgaggt ggaagttttt ctgacaccat ctttatctag attctgaagt aaataccaaa
59641 taactaccag aatggcctga cactgttttc atctgtatgt tgttccctct ctgatagcat
59701 ggagaggcct caggccattg ccagagccca gactgcttag gttacttggt ctccaaagaa
59761 gaaagtgggt ggaaatgggc catttagtat caggaatttc ttggttttct ctttttagtg
59821 gtgcacttaa cttctaatag agtcatttaa aaaaaataat ggccaccttt aggtgttcta
59881 aggcccaccc tgcagaggcc acagataagt atattcactt atctgcgaat atgctaatgg
59941 attcacaaca atcaatttta gaatatttta atcacccccc aaagaactct ggtaccaatc 60001 agccatcacc ccttaagttc cctacctgtc cagccctagg caaccactaa gttactttct
60061 ctctctacag atttgcctgt tttggacatt tcatatacat ggggtcaaac aatatgtggt
60121 cttttgcaac tggcattttt cacttcccat aatattttca aggttcatac atgttgcagc
60181 cttttattct tttttattac tgactaatat tccattgt-at agatatgcca cattttattt
60241 attcatcaat tgatagacat ttgttttgtt tctactta-ac agctatcagg aataatgctg
60301 ctatgaatat ctgcattcaa gtttttatgt acacacatgc tttcatttct cttagatgta
60361 tatctaggag tgaaatttct gggtaacatg gtaattct-at gtttaatcat atgaggaact
60421 gacagattgt tttccaaagt ggctacacca ttttacat"fcc acaccagcaa tatatgaagg
60481 ttccaatctc tccacatcct tgtcaacact tgttatta-fcc tgtttttgtt tttattatac
60541 ccatcctagt ggatgtgaag tggtatctta ttgtggct-fct tattgcattt ctatgatggc
60601 tattgatgtt gagcatcttt ttgtgttctt actgggaatt tgtatatctc ttttggagaa
60661 atgtctactc aaattctttg gattttgaat ttttaaat"tg gagtgcttgg actttttatt
60721 attaagttgt aagagttgtt tttgccttct ggattcaggt ttcttatccg acatagcatt
60781 tgcaaatatt ttctcttatt ctgtgggttg tctttctact tttctttaaa atgcaaaagt
60841 ttttaatttg gatgaattaa tgtttttcct ttgttgct-fct tccttttggt gtcatatgca
60901 agaaactatt gcctaaaaca tggtcaagga attttactcc tgtgttttct tctaagaggt
60961 ttatagtttt aggtcttatg tctaaggcta tgatccct -fct tgagttaatt tttcatgtat
61021 aaaggaatcc ttttgcccct tgctgttaga aattttcagg ttctgtgagc ctgtaagtgg
61081 ccctgagtta cctcttctgc ctccttgcta atagggcg-tg acctgttccc aatgcgggtg
61141 acatcagccc tattgctcaa tgagcagaat cagtccttat tagggactgt tcctccctgg
61201 ggcttttcaa agaagtgacc agagctccag tcactgagag gacaggcccc gaacccttgc
61261 cttttcagag aaaaaaatag agatattctt ggtctccgaa gctgaaatcc caagcttctt
61321 ttagagtctg taatgtcctg ataagctttc ttcccttt tc attcagaaag aaagtattca
61381 gtggctagag acataaggct tcctctgtat ccaaaacagc ttaacatgtt ttataaggaa
61441 acatacaaaa ctagcaacaa atacaagttt aaaaaagt a catcaagcac cttggaatga
61501 ttgcttttgg tgtgaatgag aagaataaga gttgggagtg gggatgcgga gtaaggatgg
61561 ggaactagaa acaagccaac aaaatgagat agcaccct tc acagaccaac aattacagtg
61621 tgcagatgtt gaagatggtg aatacttcat ctctgctc ct cagtggcagc aggaaattgg
61681 cctatcattg taaatatata tatttgtaaa ccctagta tt tctcaagcac caaaaaacgg
61741 acccatcatt gtgatagtta actttcataa attatctc t tttacattcc aaaaaatctg
61801 caaaatagat tttttaacca gccatcttac aaatgaggga gccagggcta agttttacat
61861 aactaaccaa attctattgt cttcattata taagtacagg tacctagaag aggcagttat
61921 gaatatgtaa gatcaaatga ccaacataag attgagtc tc agtgactttg gtgtaagcac
61981 atgagttgcc ctctatctgg agaaataagc tactgtct ta ttagcaagat ctgcagtcac
62041 acaacgcttt atgatttgta aagggctttg gtttccat ta tttcttttaa tcctggtagc
62101 tgtgagtttt acgttacaca tcacaggtga ggcacctgaa cctccctggg gttaaaagac
62161 tttccaggat cacctggcat ataaatagct gagctagaac tcaaactcag gtgttttgac
62221 tttatatccc atgcagctca tactacaccg tcctgaat ct caatgagagg attaggaaac
62281 ctgagattct ttatggcatt tgttagagaa ataaggcagg agggggttct gagcctcggt
62341 gggctcccag ggaggagagg caacacgaaa atatcacagc gattcactgc cagagaagga
62401 gatgggaatt agaggcattt cctaggggct gcctttgata gtatccagat ttctgaagaa
62461 atgcgcttag ggaaaagcat aaacatacgg aaatacct gt gcttgctgct gtttggatgt
62521 gttcttaatg taaatgctgt ttattacaat ttttccct tc taaatgtctt cgtgcatttt
62581 ccccaagtag gtaaacaaga agctgggctc agccatct ca gttgtttttt aatacttatc
62641 ctgcacatgt ccaaattgtg gctttacatg gctgatcc ta ccagattaac aatctggaat
62701 gtgagatcct gcatcacact cagaaaatac ctctgaaa-at gagttggtat gaaatgatgt
62761 gtctgtcgct catttggaac aggccctggc actggagt cc cttggggaac actggccaat
62821 ggccttctcc accactgctg acccctgggc aaagctggrag gccagctcag tcatttaatt
62881 tgaacaaatc caatagaaaa tggtaaattg aggcaatt aa ttaaaatcat tcttttcctc
62941 ttgactcttg caccttttca gcctggacaa tttagttg-aa agtggtgatg gatgcctgaa
63001 ttatccagat aattacttct ttctcacttc attaataa-ca tcgccgtRtc tccttgtgag
63061 aagtcagatg agctatttgc tcccttactg gtcagaaa-ag taagagcctt cctgaaagga
63121 gggaggcgga aaggtgggag agtcaggtgg cacaggca-gc ttctgagcct gcctcactga
63181 ggaccggccc catcctcagg gcaggtcagc tctggtc tg agcctgattc ccctcctgac
63241 aacgcttcct tctcaccccc atctctcact ccctttctcc tctctttctc tctccacagc
63301 tctctctctc tctctctctc tctctttctc tcgcccca.cc accaaatctc agctgcaatc
63361 tccaccctca ctaggaaggt ggtctgtcct attcttcc-tc ctctttctca cccttgccat
63421 ctgttgtccc aatacctctg aattcgttgg ttttttga.gt tattttatga acggggatga
63481 tggcagatgt ggaattcact actttgctgc cttaacaa-ag taccacagac tgggcggcat
63541 aaacaataga cattgatttc ctcacagctc cggattctgg aagttcaaga ttaaggtact
63601 ggcagagttg gtttcttttt tccccctcat tgctggat tc ggttgtttgt tgttgttgtt
63661 gttgttgttt ttgttttgtt ttgagacggt gtctcact-ca cccaggctgg agtgcagtgg
63721 tgcaatctca gctcactgca acctttgcct cccagctt-ca agcaattctc ctgcgtcagc
63781 ctcctgagta gctgggatta caggcaaccg ccatcacacc caactaattt ttgtattttt
63841 agtagagatg gggtttcacc atgttggcca cgctggtc-tc gaactcctga gctgaggtga 63901 tccacccacc tcagtctccc aaagtgctgg gattacag c gtgagccacc atgcctggcc
63961 tggattcggg tttttaatat ttaaggtttt ttggtataca catattcRta agttaaaYgg
64021 gactatattt tttctatcct tttaatttta ctctatgtg t ttataactct gataagcagc
64081 ttatagataa atactgtttt aaaatttaaa attttactt t ttaaattgac agaataatta
64141 tgcatattca tggagtacat ttacatggga tacatataa t gtaatcagat tagggtaatt
64201 agcatattca tcatctcaaa cattgatcat ttccttgtg t tgggaacagt caatattctc
64261 cttctagcta tttgaagcta tgtaacgtat tattgttacc tgtagtcatc ctaaggtgct
64321 atagaacact tgaactaaaa tctatcctgc tgtaatttt tatcctttaa caaatctctc
64381 cctatccttc ccgttcccca tcattcccag cctctagt cctctgttct acttttaact
64441 tctatgagat taaagctggt ttcatttgag gcctctctc c ttagcttata gatggccatc
64501 ttctccctgc atctatacgt ggtcttccct ctgtgcatg t ctgtgtccta agctctcctt
64561 ataaggacaa cagtcatatt agattagggc tcatccta c aacctcctct aatctcgtta
64621 cctctctgaa gatcctatct gcaaatatag tcacattct g aggcatttgg ggttagggtt
64681 tcaacacatg ccttactttg ctcgggctgc cttaacaaaa tagcttcaac aacagaaatg
64741 tattttctca cagttctgaa ggctagaagg ctgagatcag aaggagggct gtctcctttg
64801 ctttcagaca gctgcctttt cactgcatct tcacatggaa ggaggatgag tggggagaKa
64861 gctctctggc atcttttata agggcattaa ttcaatcat g agggtcctac cttcataaac
64921 tcatctaaac ctaatcacct cccacaggcc ccatctctt c ataccatcac acgggggatt
64981 agggcttcaa tatatggatt ttggggggca gaactgagc c cctaatagct gaacgggaac
65041 cgcaaacaaa aataggtcta cacttctggt atttcctga-g aaaggctttt aaaatctttg
65101 ataagattct gtcaactgac tagctgacca ggcacagtag tcctaatggt cttgagagtg
65161 cctcgaatgt ggcctgccca gtgtctgagt gcttcctgag atgggctttg gtcatggtgt
65221 gtgcggcagt ggagaaaggt tggaggttgc ctctagggca caacactggc agatttggta
65281 ctgtactctg gtgaccacac aaccatgaaa tcctgtggca ttcattccag gagtaggaca
65341 aatccagaaa actactgccc taggacactc ataaagcct t tcagcagcag cagaataacc
65401 caggaagaag aacgataaag cttgttgact tttgctctt t ggaggctatc tttctcctag
65461 cagagtaaac gcatctctag gggattaaag gcaggctcσa gagagctatc gactcccacg
65521 caccttcaag ccagcaatcc ttttagctca agagataac a tagccgctaa ccttggcctt
65581 ctcaggaagg gcaggtcagg gctttgatgc tgtgagtga-t tttgttggga aacaagagat
65641 ataagggtgt cccttgcaag aaagaaacac actataaaa-a aaactataaa ttagaaaaag
65701 atttatttac atgagatatt aggcttcttc aggaaagta-c tggaagaaat atttttggct
65761 attcatttat gagattttta aagtgacatc attgacatca accagcctaa aaagaaagac
65821 acaataatag catatttggg aaaaaatgat attaaactaa gacaaaaaaa ttatattggt
65881 ggtctgagga gtgtgatgaa ctcaacagca gtttggctcc attatggtca gagcatttac
65941 tgtctgattt caatctttta aatttgttga ggcttgttt a tggcacagaa gatgKtctgt
66001 attggtgaac attccatggg cacttgagaa aaagcacgt a ttctgctgag tttggtgtag
66061 ttttctacaa atggcaatta gatcttgttg gttgagggtg ttgttgagtt cctttacatc
66121 cttgctgatt ttgtctgctg gttccattaa ttgctgagaa tagggtattg acgtcagcac
66181 ctataaatga agctggggct caaaagccaa aaccaaacac actgtggcct ccagctctca
66241 atcaatcaat aaatcagtga caaagcatgt attggttaa-t ttcagcatcc ttggccgtat
66301 cctggatggt gaaggaaaga ggagatatgg gcttagttaa gaaaacttgg tatttacatc
66361 atgtatgaaa tagatatgta taggttcatg ctgatgtgct gaaacatttg taacttccct
66421 ttctaaagat tttttttttt ttgagatgga gtttcactct tgttgcccag gctggaatgc
66481 aatggtgcaa tcttggctca ctgcaacctc tgcctcccgrg gttcaagcga ttctcctgcc
66541 tcagccttcc gagtagctgg ggttccacca cacctggct a atttttgtat ttttagtaga
66601 gattgggttt ctccatgttg atcagactgg tctcaatct c ctgagctcag gcaatccacc
66661 tgtcttcgcc tcccaaagtg ttgggattac aggcgtgag-c caccacgctt ggcctttaaa
66721 gatttttatg tgttcagtca attcatcctg ttagccagac ttggttctag gtaaccatat
66781 agagcaataa gaagaaaggc aggccttcca catgctgggrt gatctatgga gcagcttact
66841 cttgttatag aacaagtgga tcctacacag acccagaagra tacccaccat ttatgcaggg
66901 ctagRtactg atgcttcctt tgttcatgca tctcttctt t ttaaggatgt ggactaccag
66961 cgtggctagg aactcaagct ctgaagccag gggcctttt c agttctgcca ctcactagct
67021 gtgtcatttg gggcatggta tttaattcct tgggcttctg tttccctatc tgtaaaaagg
67081 agatcacaat aaatgatacc tacctgacag ggttttgta-t ttattaaata agttaataca
67141 gataaggcac ttggcacagt gctggtactt ggttaatagrt ccRtaagtat tagttattat
67201 catttgtcta ccaatatatc ctttcacgtt cagttccct t tcttctatgg gtatgggtca
67261 ttccagtgtg caaacataac atccacttca gactcttccrc caaggatacc aagatgagta
67321 caaaatgttt ttcttttagt ttacttctag caagaccta-t ataaatagtc aaactataag
67381 accaaatatc accttaagag agataaagtg gctgctgga-g tcatgggtgg tggccaagta
67441 agatgaactg tttttacaaa agaccccaaa cctctgaga-g attttgcaaa tcattccttt
67501 ggatgcttgc agaatggtca atggacattt ttgtgcta t tgtgttttac taaagatgtc
67561 catgttatat ctttttttac taggtggaat ttcacatttt tagtggaaat gccaacttct
67621 tattttatac aaaatttgct tttacttctt attttgtat c tttatatctt caatgcagtt
67681 tctgcagaaa ctttgaagct ttcaaattat tttttcag rt aggctatcct ttcatctctt
67741 taacatctat gtaaaacaag taataatctt ctcagttaat ttataaaaaa tcatccaaag 67801 cataactatg ggatagcatt tgcaatccaa tcaaaaaaat ccatgctt-fcg gctgaaagtt
67861 gagttgcctt tgaacttcct gaatggtgta ggggatgagc agggctgccc cggccaccag
67921 tatccaggac cccagccccc aRtcagggat ggaaagtaaa ccctcacaat aaagtctgtt
67981 agagagtttc ttatgttaag gaattcagag ctggaattca tcattttg-fcg atttttttat
68041 ggtagggaaa tactttcaac gttttagttt cattgaagat gaatactaca tgacaaaatg
68101 Yccctcccat tcactaatcc aatcagttgt tccaaacctt ctcaaggcfcg tgactctccc
68161 agatctagct gtggcaccct cacaagggag aaaggacttt cagcccttgg ggaagtctct
68221 tagtgtccta taatcttctt tacctcatcc cccaagtata ggggttta-at taagtaggcc
68281 aagattcttt aatttttatt ctccctcctc tcaccctctg aattctacat taattatttt
68341 ctgaccatca caactctttt aaaaccatac tatcatacca ttcaaaagat gtccattaca
68401 gggtctgatt tcaacttata cacacgttct caatatatat ttatggactg tcaaggtttt
68461 tgtatgccag gttaaggatt ctagattccc cataaaaagg aagattcagt gaggaatttt
68521 Rtatatggag agatgaatcc tgcagaaaca aaaacactta gatgtagg-ac agggaaaaca
68581 ggaacacaga aaagagagtc ccaagaagta agaaaagata cagaagagag tggtggtgcc
68641 catcttgcct gccccaaccc tctstaggtg gagatggcca ttgaaggctc aagtctaggc
68701 tctgcccacc tgggctctga gcccatgaga ccaaggccca caggatctgc ccatgagaca
68761 cctcttcctc actaatcagt caagccagta gcgggtcttc ctgtcctasaa cctggttcca
68821 ctgtgcacag agagcccctg agtcccatgt cctaaaacat gtgaaggttg attagacaaa
68881 ttgggtcatt cttgtcatac tgaaccaaat aagactccag gggccaaggg gaaaaagcac
68941 ttggggcaca aagcacctgc tccaagaatt aaattttctc caagcccRgc tgctaaaaca
69001 gcctggtgta accctaagac cagttttgcc tagtagctgc taaaacaacc tgcctctaag
69061 actaatttta cctaccactg tcactcacca gtcagagctt gccagctccc aaaagcttct
69121 ttagtgccaa agagttttct ttcaaaacag tatgtgatat ttctctttcct gataaaaStc
69181 ccaatcctct ttttgttctt cagacctagg gaagaccagg gagtctgcgt gtttgccttg
69241 aattggaatt cttgcttccc aaataaaagg ttttaaattt ggagatttgt ctctgtatat
69301 tatttgactt cagcagctgc agtctctgtg aaagcagtgg tgcagcacsaa tggttcagaa
69361 ctgtggcatc tgaaactagc tggcctgggc ttgagcccta cttaggcact tattagtcat
69421 gtgattttga gcaagtcact tgactttctt atgcattagt ttcctcactc taaagatggg
69481 aataagcgca gccctgcctt ataaagttac tcttgtgata ataattaa-at gaattaacat
69541 ggcttaacag catctggcaa aagtaggtaa ggacttatac aaacattagc tgtgtacatt
69601 gttgttattg ttacattgta acgtgtgcac aaatcatggt ttgcaggaca tctccactta
69661 ctggagctcc catggctgat gcgctgccaa acccttgcta gctcctcttc tgttgccctc
69721 tgcttcaagc agggtggact ttctctggaa gtaaaatgcc agcacctgtc tattagtttg
69781 aaccatatat gacattgcca ttttttgtag gtcacaaatt attgaacatt gacaattttc
69841 tatggtttaa tctaaaataa gtaatgctct tggcataaac ctgcaaacεaa acaactgcac
69901 ttcacactct gaattatgac cttgacctcc gttttgagaa ccagctttag tgtcaattct
69961 ttgagtccta gacttgccca ttttgggctt gctacctcct ctgttaaccc tagggctgag
70021 gaatgataat aatgatgata ataatagggg atcctctata gctaaagggt atatatgata
70081 gttgcaaggg gaacagaaat cactctaact tagaatagtg tggctggtat atttaccctc
70141 agattagagt agttataaca taaggcatag atggccagat ggtatccttt caccccatct
70201 gcctcataag gatccctaac ttcaaaagtc taatgttaat tagtaagtga tagttgtcaa
70261 cttctagttt aaccttagaa tatttatata tcatgggaca acttcctagg cacacagtac
70321 tgtcacaaaa agctgttatt tccataccaa cagaaacgtg ggcgaagcsat ataaacagac
70381 agttcccggt aagggacaga attcttaaat taggtgcagt ggctcatgct tataaaccca
70441 acaccttggg aggccaaggc aggaagagtg cttgagccca ggatttcaag accaacctgg
70501 gtgataaaaa gttacaaaaa aaaaagggtt tgttttgttt cgttttttta aaaaaactgg
70561 gcatcgtggc atgcacctgt gagtcccagc tcctggggag actgaggggc ttgagccggg
70621 gatgttgagg ctgcaatgag tcataatcat gccactgtac tccagcctgg gtgatagaac
70681 aagaccctgc ctcaaaaaca aacaaacaaa caaacgaaca aaaaatccεag ccataattac
70741 actgagttac acatgataaa cttcctacga gttggagagt gatacatccc tccagtgaga
70801 tgtgagggaa gaggggactg atactcctat tgactcactt ctctggaccc acttcctatt
70861 gtttctccag acttagtttc aggtttgaag ataaagcttc tttaagaggt cagttagaaa
70921 atgcaagatc atcttgtgtt tatgtgccat atgctctttt catgactctc attcgtctca
70981 tctcatctca tctcatctca tctcatctca tctcatctca tctcttctct tctcttctct
71041 tctcttctct tctcttctct tctcttctct tctcttctct tctcatccca tcccatccca
71101 tcccatccca tcccatgcca tcccatccca tcccatccca tctcatctca tctcatctca
71161 ttggtcctgt cctgagtcct gttgagtcct cggtgctgtg ctagccacac aggaaagaca
71221 tacatgacac tatccttgcc ctccaaaaaa gtcagaaagg caaacagtεaa gtagaagaaa
71281 atgttagaat cctgatgcat cttctttgct cctgattcag gattcaggεsg cttattttcc
71341 cccagtattt gggtaaacag ccaaacaatt gaatctcaca ttctagggtg gagtggagag
71401 acatcacctt gccataatac atcggctttc ctgggagtaa agtcaagttg gaatgctgtc
71461 tgtcagcggc agttccactg gatatatcaa accctgcatc tctcctctcc tttttttttt
71521 ttttttttgt ggtgaggatg atggagtaaa tatctccttg gtactctg-ag agcctgcaga
71581 gagaggtgtt tgcatgagga ggcaggaacc tattctattt ggattgagaa ctttttgcag
71641 tcacaagtga tgagtgacag caaaaaaaag ttatgaatta tagtttatta tttccattac 71701 tcttcccacc tctccctggg ctgggaactt ctttcctggg cagagacaga taccttttac
71761 ctgtctggct ctgcttgtgg tgttttaaga gggcagcaag ttggcctcca agggtttctt
71821 tccatcctgt gatttgtata ttcctggatt tgctgacgtg tttcagacaa cagactaatt
71881 gctctgcctg tgttgttctc cctcctgctt ttgaaggatc ttatttcacg tgttgtgccc
71941 tctctctcct atttccagat tctgcttgtt ggcaacatgg tcattccaag cattggaatt
72001 aggcttgggt gtacattctg tttcaggtct cagtgattgg ggtggcaata ggcgcaaatt
72061 gtttaatttc ttagaatccg ttttctcatc tttaaaaggt caataagaac catcttgtta
72121 ctgcacagat tttgaaacca gaYctttggt tccattttgg ctgtttttgg ttccattttg
72181 ctgttacttg gctgtaagcc cttgagatca gctttacttc tctgctcctc agttttctca
72241 cctgcaaagt gggggtgatg ataccactaa cttcataagg cttgtgagga ttaagtgaag
72301 aaataaatgt aaagtgctta taacaatgtc tgtcatacat taagtaccca atagatatta
72361 aatatcatta ttatctgtca gtgtcattct gaggattaac taggaaaaca tgcataaagt
72421 gattagaaca gtgcatataa agcatgctat gttgtttccg tatgaatctt gtcaaatccc
72481 tactacctta aaaatatttt tttcatcctg aatcactagc tactcctctc tttattcctc
72541 ctgaattttc ccacaatgta cttctccaaa atgtagatca cacacgttgt ctccattttt
72601 ctcacttcca ttcacttctc agctcaatgc aatccagtat aggccctctc catcactcaa
72661 aaacgtggaa actgtcctat taatgttgcc agagctcatt gaacaaaccc aggggcagca
72721 tctgaatctt tatcctgctt gacctgccta cagcttttga cactgatgtg cattgcatac
72781 ttctcgaagc ccttctctcc actgggtttc atgtcatcac tttctgctag tcctcctgcc
72841 gtcttgcatg caggaccttt gcagcttgct ttacaactgt tgctctccct cttctttaaa
72901 catcagtctt ctcccgggct ctgtccttgt tactctttat ttcacctatt ctgtggcttc
72961 aacttctacc tctatgctga gagctccaca tttatagctt cagctcagtt tccttctctg
73021 agctcctcac ctaacaaata taatggacaa acccaaccaa tttgatgtct tggaggcatc
73081 ttaaacacaa agtgtttaaa actgaataca tcatctcacc tacccttgac tcttaataag
73141 tctcttccct gtgttccttc cttgtattag taaatggtac tgctgtcctt catatgtcca
73201 agccggaaac ctaagagtca tcatagtctt ttcccctttt tttttttttt actactgcat
73261 cccatcaatc attaaggcta agaagtatgc tttttaaata tctcctccaa cccttctcta
73321 ctgcctcaga tgtgaacatg gctctcctgt gttattataa tagtctcctt gcgctccagt
73381 tgcagctaca caaatcattg tgtggtcccc tgaatatttc acgctcgctc acggctctga
73441 gtccaggatg atgcctatgt ctgcctggaa tggttccttc ccattagttt gaaaaacaga
73501 attaaaatct tctctagcct tccctgatgt ccctggcaca tttagttgct gctccgaatg
73561 ctacccatgg gctttgaatg tatttccagt gtggtaatat ctaattttac tataactgtt
73621 cacttggccg tccatctatc cgttactatg aacatcttaa aactgaaggc aacgcctttt
73681 catttttgtc atcttagtgc caggcacacc aaaacctttc cacctggatg ccccacaaac
73741 atctcaaata tgacatgctt gctgaatgac tgaatgaatg aatttgttga acaaatcttt
73801 tctatcttct gtgtcttgag tgtgggacac aactatcttc ctcactttcg gtgacaaata
73861 tttcatcacc tcttggttga cagagatgtt aactaacact aaaacatgtc agttctcatt
73921 ggccatttat aacttgtctt tttctcaagc cccagctacc tataagaagt gataaatgaa
73981 acttatccaa ggtaagtctg ttgttccata gaaagagcat cctttgaatt aaagcacagc
74041 attgatagga gtgcttcctg ggtgcacagt tggatttgaa caggatgttg atatttcaga
74101 gtatagtttt tacctggcat gtattttaaa ggattaataa aaacaagttg gagaattatt
74161 tgcaggtcac ttttttaaag ttStgtatac aaacacaaat acacacacac atatttcatt
74221 tgcaaatcta aaaacattta ctgagctaca gtacaaccca tcaatcctac ttctgggtat
74281 tcatccagaa gaactaaaat caggatctca aRgagatatc tgcatttctg tgttcattgc
74341 agcattttcc ccaataccca agatgtagaa acagcctaaa tgttcattgt cttgacagat
74401 gaatgcRggt aaagaaaatg tgatgtatgc aaaccatgga atactattca gctttaaaaa
74461 aagaacattt tacaataggt gacaacatgg atgaactttg aggacattaa aacaagacat
74521 ggaaagataa atccaacatg attctacttt taatgaggga tataaaatag tcaaattcat
74581 agattcaggg tagggatggt ggttgccagg ggcttgggga aaggaaaaat ggggagttat
74641 taatcaacag gcacaaagtc tcagtaaggc aagatgaatc atctctagat atatgctgta
74701 caacatcatg cctatcatca gcaataatgc attacacact tacaatttgt aagaaaatag
74761 atttcatgtt aagtgttctt gctacaataa agtaaaacaa aatacttact aaataacaaa
74821 ggaaaaaatt tcacatctta gtgcagtaga tggtttttag caatttctac tatctgttgg
74881 gtcacactta acatagagaa tgcttttgca ttgtgtcttg tgaaatttgt tctagctcta
74941 cactttataa aactttgtta tactctgaga aaaggcagag agtccacttt ttaattcttt
75001 tttatgactc agtaatgaga tacaattttt attttaacga aattctttgc gatttagaaa
75061 aatgaagtag tttcaaattg gaaatctaaa ctctctggta catggaccac cagctcactt
75121 cttaagcaaa agaaccaatc agttaataac aatgaaacat aaagctatga agggtagaat
75181 atatttatca tttctcagct atgtgaaaaa tgccaccatg ccagctttca tcatctttcc
75241 ccttatcatc taaatgtata tttgaaatac agcatcataa actaaatgga tgtttttaag
75301 ttgtcatgtt agactttcgc tggtcataaa gctggctgat attattttct attatctgag
75361 cagccaatca aggcttttta aatacaaatc ttatacaact ctccaaaatc aatgttacat
75421 aactaaatgc acctggtgtg cttaactgtt aatttttcct atcctttatt actcaatgag
75481 taatgaatca attatgatag agacagttat caatttcRaa tattaaaaag aataaataga
75541 ggacaacata ctttttctaa agcccaactt tttcacttgt tgtcagatca ctgaatttag 75601 tgaatgaatt aattttgcta atgttaatta tctgtaagaa atgtattacc ctaaataat c
75661 aggattaaaa caagcccatg gtgtggcttt cttttttttt taagttgagg tattattaca
75721 caaagaaaaa gaagcaattc taaattatgt atggaattaa tcttggttgg acttgggta-a
75781 gccacaatgg gaaattaggc gacagttaat cttctgataa atacatctgg atttagacta
75841 cacaattgtt tagaagttat ttgggaactt agaggacaat tcctctaggt aaattgttt c
75901 ccctaagttc ccagcaatgg ggtgattctg aggctaaaac aaataaaacc ccccaagccc
75961 cccaaaactg tcttacccac aacaaaagag aagcacaaca gcccaataat tttaaagaa-t
76021 aaagctagat ctgcttagat gcaaattttt aaaaatcaga ttgtatagac acaatatga-t
76081 caaatataca attagcaaag ataagcctct gaactgcaat aagccaactc aaaaaaaaaa
76141 aaaaaaaata caYgacggcc cagccggaga taagagagtc agcccagtat tttctctcσa
76201 tgtttttaag agcagcagtt atggtgacag aatctaccac agggtgatct atgctctcca
76261 caccgatgac agaagtgaca ttcactgcat tgcacaacaa attgttttca acttacttg-t
76321 ttttggacat gctgctgcag tcggagggaa attggaaatc ttgtacacac cttataaggra
76381 gtaacatatg acactgcatt tttcaggaaa tcagttggac ctcagatttg gtcaaagta-c
76441 ttctagatcc cattgaagtg gtgatactgt gatgctgaga atctgctctg agcacttgt t
76501 tagttgatat tggggcagta aaccatatgg aaggtagatt ctgtcactct aaagatttt c
76561 tcctcctttt catccagggt tatatgacta ttcttcttac tacaagaatg gcaaaatta-c
76621 agtggaggaa actaatcatt aaattttttt ttttttttct tttttttttt tttttttttt
76681 tttttttttt ttaccacaga gctctttgat catctggtaa gagctaacga cctcttata-g
76741 aaatctacaa atgcccagaa aattttgcac agaacttcaa gaggttactc agctactga-a
76801 atccatccct ggaccccccg aaactcctta attaagatgt ttactgtgac aactggaggra
76861 tcaggttcat accttactct tctctgtctg tgacatgact tttacccctg acccagaca-g
76921 agccttcaat attgccccag agacccacct tgccttacag tgtcttgata gtggagcca-c
76981 accaagctac tcaggcaaga tgtgtcactg ataactcctc agtgcagata tcaagtttσt
77041 gtaagaatgt cctagtggca aaagttcaca ctaagcacag tacatcaaga atacaaata_c
77101 agcaagtctg gggtgacaga ttttctacat tgttctactt tctgcctctc cctcttccc-t
77161 ggtctatagt taccgtgcat agtgacaggc cagacagaca gaccacactc cccacttggjc
77221 tcagactctg tcctgtactc tggctctttc tcttttgttt ctccatgagc caaattctt t
77281 aggaattgct ctgaatgaac ctcctggaaa tctctaggat cccagctgta tctcccct t
77341 gtgatgtctt tgttactgag gagtaattaa ttgttacctg gtgtgacatt taaatatYct
77401 tagtattctg tcattgtttc tgaccatcct ccttctgtag ctaggtcctt gagagcaagra
77461 tgtctatgga tattacccct tggagctaag aaatggatca attgagatac gtttcaata_c
77521 tggattgaac tattaaagca ttaggcaggt agcaaggctg aatcaaaata gtcttagga-a
77581 cattggaata ggaagggcat gctgtctcct ctgcRttttt caaacttttt gaaagtgatg
77641 cattgtaata aatcttttcc ccattacgat agagtataca aaatatgtgt aatagagac-a
77701 aaaattatct gaaacaaaat ttacccatat tacatgtgct gcactctatt ttctattctg
77761 ttcaatttta tattaaaaaa acaataagaa acactgttca ctgcccatta catggatttc
77821 atgacccact aataggtggc gacttgtttg caaaacactg gcttatccca tgggattggja
77881 ttaaacttga caaggaattc tgctctgcct tgcattcttc tctaaaatcc ataaaaagct
77941 ttttttttct atttattaat ttacataata ttcaaagaga atccttataa cagttctga-a
78001 ctgggtttta tattaggttt cacagataac aagtggcaaa actcatcgcc ataaccagtic
78061 ttggcatttc aaatcgacgg ctatttccat cttatcatgc tgcaatctat catctgatt t
78121 ttccctgcct agactcccca ccttggctgg aagtacccaa aaagctagga atgtacctta
78181 gccatgctag gtacccagga ggcacttaat gaatatatga taaacagaat ggaataaca.c
78241 tcttggtcaa aagccatgtc ttggcttggc atgttttggg acatctttgt tccaaaacct
78301 tatataattc tctctctctc ttttttatta tactttaagt tctagggtac atgtgcacaa
78361 catgcaggtt tgttacatat gtatacatgt accatgttgg cttgctgcac ccaccaactc
78421 gtcatttaca ttaggtattt ctcccaatgc tatccctccc cccacccccc taccccatgjg
78481 caggccccgg tttgtgatgt tccccgccct gtgtccatgt gttctcattg ttcaactccc
78541 acctatgagt gagaacatgt ggcgtttggt tttctgtcct tgtgatactt tgcttagaat
78601 gatgaaaacc ttatgtaatt cttaataatc atactttctt catactctat gcgccattc:a
78661 ttaatgggtt ggcactggaa acatttccca agcttatagg gaattcttca atgaacatsg
78721 aggagctact gagagctaaa cactctttgg ttcctgcctg tgattgagtt tttcccagaa
78781 ctcaaagaga gaatttcaga aaggccaata aaagccccca acaggagagt ttttgttttt
78841 gctagttttc ccaaacagct ggcttcccta aggctgtaat ttgtaagcct ggtttctacc
78901 agactctaaa tccataatca atgataagct atcaagcata tgccctaatt tatattactt
78961 tgggcctttt ctagccaaaa ccaacatccc tggggaaata ccaaaataca tctgtcctεaa
79021 ggtagatacc ttatgtctgg ggaggtaggg ggtggacagc taagacttgg tattgaacsg
79081 gactgagtaa tYgtctaatg aatgaatgag tgtatggata atcaaagtgc aaatgcctgjc
79141 tatacatatg taggtattca gaatatttta tatgcattta tatgaggctc ttttccctga
79201 tgacctagga agggaaaaga cggcaataac atagtcttgt gggtacttgg ggaagaaa-ag
79261 tcaggtggag agagagaaac tgaggggagc aaacagaagg taaggagaga agaataaa-ag
79321 aatgagaggg aaacatctgg ccggaaaagc aggaaggcca gcagctctga atgcagatca
79381 caatctttgt tagtcatctt tatcttactg gttactttgc tactcaaagt acacatttc-:c
79441 tatggtggaa actcccttgt ttacttattc ttcctgaccc aggtttaaaa ggcctgccta 79501 accatctcag taggcttttc ctagctgata tccttctgag ctgtggtaga gaaaggggaa
79561 gcagtgccct catggctcct ggatttacag ttcctgagga agaactgaca aatagaggaa
79621 gacttcccta atatcaaatg aagcagaacc ttctgggcag aaggaaaaca ggtgatgttg
79681 caatgacagg gctcaccttt ccacctcgtg tttgatgagg gtttgagaaa agagccacat
79741 tctttccaaa agtcaggtca gaagcctttc cacactttgg tttcccaatt cagcacccgt
79801 aatgtcaaat aaaacgaagg cccttgcccc aagtgaagtc atcagcaaat atctctttgc
79861 tttccggggg actgtgttct ctcacaacat cttttggaat tatcacttca tactgaaaca
79921 agggtttgat cttttcatga gatgtatggt gatgaaatta aggccagggg ctctggggac
79981 agaagagaag gctggcgccM ctcgtatgcc ctggagaaac agtgagatga agagcacagc
80041 ctctagagcc agagtgtctg gatctaaaat tggctctgcc aacaagcatg taagtcacat
80101 agcttttata tgtttcatat gaaaMtggaa taaaagtctt atctatagga ataaataagt
80161 caatagaagt gacgcactta aaacagtgtc tgcgtatagt aggcattcag tgaggtgctg
80221 gctattactg gggtgtgaga acagaaacag tcatttgctc aatcccaagt ttattttggt
80281 actttgtttc tttcttgtaa taaggaccag tagtttcaag aatcctagaa cgttagaact
80341 gaaaggaacg ttcattttat ggctatgtaa ggctcagaga gagtggagcc ctccaaggtc
80401 acgcagctac ctggtggcag tttcaagacc aaacaccagg cttcccattt tctggaccac
80461 tctccactct accaccctcc ttccttggag gacgatgtcc aggaccaaga taatgctgtt
80521 agggcaatga taacaactgg aactgtagta gcccctccaa cggctccctt gtcactacaa
80581 agacaatctt aagcKggttc attcattcat tcattcactc agcactgctt tttaagctat
80641 tctcaaacag tacagaaaag cgaaacacag ttctcattct taaagagctt ctattgaaat
80701 tagagcaata agatatgaag ataaaattat acaatagtac aatcacttac attatacaat
80761 atttatataa ttatatttta taaatataaa tatattttat atttataaat tatacaataa
80821 tacaatcatt tatgttaagt gtctaagtat tagacagctt acatatattc tatctaatca
80881 gttgctagta aaagagttta cattaaggtt aataacatta tgaattccta aaataaatga
80941 aaccaagcaa gcaaggaaaa agatgtgcaa agcagtttgg aggtttaata agacaaaaaa
81001 agacacctgg ctagaaggat caggaaagtc ttcatgcagt aagagtaagt ggcattagat
81061 Rtgggccctg aaacatgaat aggtaacaga attagaatgt gaccttttcc tctctcctcc
81121 atgaataatt actttctaaa tataaatata Ygcaaatgta tacatatact cgtacaaaga
81181 aatgaaatac aattctacat aaattttcta tggaatttca aagacaagta aaacataaat
81241 gaatccaaaa ggcaagaact tccagcactt ccaccctatt ctgtgcaagg caattgaaga
81301 ataagagggc ttgttttaag aattatcatc acatatgaac ttctagttca tctgtaacag
81361 tggttcccaa cctttttgac accagggact ggttttgtgg aagacagttt ttccacggat
81421 ggggatcggg agtgagatgg gactggggtg tgggggtgat agtttcaaga tgaaactgtt
81481 ccaccttaga tcatcaggca ttagattctc ataaggagtg cacaacctag acccctagca
81541 tgaacagttc acaacagggt tcatgctcct atgagaatgt aatccgctgc tggtctggca
81601 gggggcagag ttcaggccat aatgctggct tgcctgccac ttacctcctg ctatgtggcc
81661 tggaacctaa cagaccagag agtggtactc gtctgtggcc tgggcttggg gacccctgat
81721 ctataggata caagacaagt cactcctcac aaggaagaag gatggtcatg atcagatttg
81781 gagagacaag ctgatagact ggatttctac tgccaccatg cctgtgtatc agtggaggtc
81841 ttaagtaaat tattggataa tactgcagga ggacagtcag agccactgca ggactccagg
81901 ctagataggg aagtgggRgt aaaaatacag agaaggacat ttgttctata atgcagactg
81961 ttttccaaag cagctacact atcttacatt cccatcagca atgaagcagg gttccagctt
82021 ctccacatcc acattatctg tcttttcaat tacggtcatt ccagtgaata tgaattaata
82081 tctcattgtg gtttcaattt gtattttcct gatggttaat gatgtcaagc atctttttga
82141 gtgcttatag gcaatttgta aatcttcttt gagaaatatc tgttcgtgtc ctttgtccag
82201 ttttaaactg ggttgtcatt tcatccttga gttgtaataa ttttttatta cggctacaag
82261 tcctttacca gatatatgat ttgcaaatat tttcttccat cctttggttt gtcctcttac
82321 tttctttatc ttatgttttg aagcacaaat gttttataat tttgatgaag tcctatttat
82381 gtcgtttttc cttttgtcac ttatgctttt attgtcattt ttaggaaacc actaagaaac
82441 caaggttaca cagatttact tctatatttt tttctaaaag ctttatagtt ttaactttta
82501 catgaaggtc tatgatccat tttgagtatt tttttttggc atggtgtgag aaagtggtcc
82561 aactttactt taaaaaaata aactttactt tttagaaatt ttagatttac agaaaaaatt
82621 gagaagatag tacaaagatt tcccatatat gctacgtttc ccctattagt gtggtatatt
82681 tgttacaact aatgaaccaa cagtgataaa ttattattaa ctgaagtcca taatttattc
82741 agatttttct aagttttata taatctgctt tttttttttt gttctgggat ctcatcatgg
82801 ataccacact acatttggtc atcatgtctc cctaggcttc tttggctgtg acagtttctc
82861 tggcttttct tgcttttaat gacctcaaca gtattgagga gtagtggtag gacatcataa
82921 agtgtccttc tgttgggatt taactgatgt ttttattatg attagagtag ggatatatgc
82981 ctttagactg ggctagggat atgtgttttg caaatattgt ttcccagtct gtgaatggtt
83041 cttcatcctc ttaaaaggtc ttttgcaaag aRgaaacttt taattttaat gaagttcaac
83101 ctatcatttt cttctatatt ttcttttgga agtttcRtag ttttgtgttt tacatttatg
83161 tctaatccat attgagttaa ttttttaaaa atgtttaagg tttatgtctt gttttatttt
83221 atttttttaa gatgRattct ctttctgctg cccaggctgg ag gcagtgg catgatctYS
83281 gctcactgca acctccatct cttgggttca agagattctc ctgcctcagc ctcccaagta
83341 gctgggatta taggcactca ccaccacccc tagctaattt ttgtattttt agtagagaca 83401 gggtttcacc atgttggcca ggctggtctt gaactcctga tctcaagtga tctgcccacc
83461 tcagcctccc aaactgctga ggttacagca tgagccactg ctcgcagcct atgtcttgtt
83521 ttacattttt acRtgtagac ttccaattgt tcctgcacat ttgttgaaag gatgattctt
83581 tctccatgga attgcctttg cttctttgtc acagaagact tgactatttg tgtgggttta
83641 tttctaggct ctgtatgcca ttccagtgat ttatgtgtct attctttctc gagtaccaca
83701 ctgttttaat tgctgtagca tcatagtaag tcttgaagct gggaaatttc agtcctttga
83761 ctttattctt ctttaatatt gtgtttggta ttcagggtct tttgcttttt cgtataaact
83821 ttagagtcag tttgttggta cccataatgt agcttgctgt gatttttatt gggttaatat
83881 tgaatctata aatcaattta tgaaaaactg acaatattaa gtctgccaat ccataattat
83941 ggactatgtc tgcattcatt tagatccttg atttttttta atcagaatgt tgaagttttt
84001 tgcatggtga ccctatacgt attttgttag atttatttca tttttcagtg ttattataaa
84061 tagcatttta tcagtatata aaaaaagcat caacttttgt atatcagtca tgtaatctgc
84121 aaacttgata taatcacttt ttagttccag gaaattgttt tggtgattat ttgggatctt
84181 ctacatggat aatcatatca tctgtgcatg cagataggtt ttttagctag gacttccagt
84241 acaacattga gtaggaatag tgagagacat tcttgctgtg tatacaattt tatgggaaaa
84301 aaattcagtt tttcagtatg atgttaacat ttttttttct ttcttttggt agctgttctt
84361 tttcaagttg agaaagttca tctttatttt tattttgttg agagttttta tcaagaattg
84421 cttttggagt ttgttaagtg ctttttctgc attaattggt atcatcatgt tttttcttcc
84481 ttagctagct gaggtgttag gttatattca gtgttgtgat gggttatatt gatttaatgt
84541 tgaattggat ttgaatacct ggaataaatc ccacttggtc atgatttgta attctttttt
84601 atacatcatt gaatttgatt tgttaatatt tttaaaggat ttttgcttct atgttcatga
84661 gagatattgg tctgtaattt tccattttga atatctttat attagagccc tattgatggg
84721 ctggtaaagt cagggaggga aaacagtcta caattttatg gttaaatatc aatgttttag
84781 tgtgcctggg tccctggcac gagaacttca caagtgtttc atagctccct tcactttgat
84841 aagacaggaa gtgtataggg ggctggaggc aggaaaatat actttcccca ggtggggtaa
84901 ggctctggta aaatcttttc cctgcaaagt aggccttggt tatggtgcat gttctagagt
84961 tatttcaaaa tgggaacttt ttctaccacc tgctagagcc atgagagttt tcttagctct
85021 cactgtgaaa acctggtggg gttcctagag gtaaagccca tgaacgtgta gtgctgcctt
85081 gtatgactga ggcctccatg ggtttctcac tctcaggcta gtccacactt agcgtccagc
85141 aatttgtcaa agttaccatt ttaattttcc tatcaattta tggcaatagt gattccttct
85201 ccaggtaagc agatctgagt gactctctgg gttcgactac ctgtccagat tttggaatga
85261 ctgccctgaa acctcagttc cctgatggat ctgagcaaag tgattgactt ttagtttatt
85321 cttttttttc ctcttattgt aagatcggga gtgatgactt ccaagctctt aacatgcagg
85381 gctgaaactt aaagttccaa cttcattctt tgcattcgaa tatgcaattg taccagcatc
85441 gcttgttgaa aagactcttc tttccccatt gaatcttgtg acactcttgt caaaaaatca
85501 cttaaccata aatgtgaggg tttatctctg gactctcatt ttatcctgct gatctatgtg
85561 tctactctta tgccaatacc acactgtctt gattatgata gctttgtagt aagttttgaa
85621 atcaggcagt gtgagtcctc caactccatt gttctttttc aagattgact attccggttt
85681 ctttgcattt ctatatgatt tttaagatca gcttttaaat tcctgcaaat aagcaaataa
85741 aattttaaag tagattccct ggaatctcca gatcagtttg gaaagtttgg ctatcttaac
85801 agtattaagt cttaactcat tccatttatt taggcttctt taatttcttt caaatatgct
85861 tcagagtttt caatatacaa atattatact ccttttggta aatttatttc tacatatttt
85921 atcctttagt gctattaaaa ataacatttt tttaatttca tttttagatt gctcattgtt
85981 agtgtctaga aataaaattg atttttatgt attgacctcc tatcctgcaa tcctgcaatc
86041 ctgcaaaacg tacttatttg gtttttaaat tttttttcag gttttttttt atggttttga
86101 gtatttcttt tagggtgatt gcttaaagct tctctggttc aataaaagtg aatttaaaaa
86161 tgcccgcaag agttatcaat tggattgatt attatactaa aaaaatactc taggtaaagt
86221 ttggtgataa gatgaacagt agctagaatg agttatggag ttgagagggg atatttttgt
86281 catgggccca acttgagggt gtttataggc tgaagagaag aagccagtgg gaagaaagag
86341 tttgatatta gagaaaagaa ggagacggtg gatgaagaag tggcaaagga gtcagaaggg
86401 agtgggttag gtgtagctac tggttctgaa ataccttaag gtttaccttg tcttcctaga
86461 tattggggaa tgagtccagg gtatagatat gaatgaacat gtggactgga atgtacaata
86521 aaaaagctga caggaagcaa gatgctggtg gagagtatgc ttgataactt caatttctcc
86581 atgacatagg agtccagggg atttgctgaa gggagaggtt ttgaggagag tagtgaggtt
86641 cggaataact atttagaaaa caatttggaa tttgagaatt aaagccatct tttaaataga
86701 aagtctttct aattaaaaat ctctaaaggc ttttaataga attatatttt taaaggatag
86761 aaaattctct aaagtctttt taatagaaag aattctatca agaagaatag aaaattctct
86821 aaagtctttt taataaaata ttctccatat tactaMggca actgaaatca gaccagaatg
86881 aaggtggatg tctataagat ccctgctgtg tttccatctt ctggatggtt tgccaaaaaa
86941 gtctaagaga aattttagct aagcattatg taaactatcσ tgtgaccaag acccacttgg
87001 ctttgatccc cattacccca acccctttcc tgaattcttt attgtctctg aaatagatca
87061 atgaggaaat ggtttctttc caaacctctg ttggggataa taaacctgct acatgcctgg
87121 taggatgatc atgcttctgc cttaaggctt atatcctgga atatatcctg gaatatatat
87181 atataNatNt ctcctggaat atatcctctg atgtaaaaat taaatcccag tttaaacata
87241 aaatcctgga atctatccct taacatctgc tccaacagaa actgaagtct gagctagtgt 87301 ttttttcttc cccagagttg tgcttatgca tgtagaggtg ttatggactg aatgtttgtg
87361 tctcccccag aagtcatata ttgaagactt aaccccccag tgtgatgata tttggatatg
87421 ggcctttggg tggtaaagtt aggtggggcc atgagggtgg ggtgctcgtg atgggattag
87481 tgcccttata aaaagagatg tgagagagct tgttctttct ccttccatgc ttgcaaaaga
87541 ggtcatgtga acacataata agaaggtagc catctgcaag ccaggaagag agccctcact
87601 agaacttgac cctgccagca tcttgatctt ggactttcag cctccagatt gtgagaaaat
87661 aaatgtctgt tgtttgaacc acacaactca taatttttta cggcagcctg agcagattaa
87721 gacataWttt ggtactgaga agcagggtgc tactgtaacc ataactaaac atgtggaagc
87781 agctttgaaa ctgggcaatg ggtaatgggt agaggccaga aaagtttttt tttgttgttt
87841 gtttgtttga ttatttttat ttttgtagac acagggtttt gctatgttgc ccaagctaat
87901 cttgaactcc tgttctcaag cgatcttcta gcctcagcct cctaaagtgc tggaatcgca
87961 agtgtaagtg atcaaagYgg ccaaaatacc cccctttttt attatacttt aagttctggg
88021 atacatgtgc aaaacatgca gatttgtgac ataggtatac acgtgccatg gtggtttgct
88081 gcacccatca acccattatc tacagtaggt atttccctaa tgctatccct cccttatccc
88141 ccaaccccct gacaggccca ggtgtgtgat gttcacctcc ctgtgtccgt gtgttctcat
88201 tgttcacctc ccacttatga gtgagaatat gcggtgtttg gttttctgtt cctgtgctag
88261 tttgctaaga atgattgttt ccagcttcat ccatgtccct gcaaaggaca tgaactcatc
88321 cttttttatg gctgcatagt attccatggt gtatatgtgc cacattttct tcatccagtc
88381 tatcactgat ggacatttgg gttggtttca agtctttgct attgtgaaca gtgctgcaat
88441 aaacatacat gtctttatag tagaatgatt tataatcctt tgggtatata cccagcaatg
88501 gaattgctgg gtcaaaaggt atttctggtt ctagatcctt gaggaatcgc cacactgtca
88561 ttcatggcca tactgcccaa tgtaatttat agattcaatg ctatccccat caagctacca
88621 ttgattttct tcacagaatt agaaaaaact actttaaatt tcatatggaa tcaaaaaaga
88681 gccagtatag ccaagacaat cctaagcaaa aagaacaaag ctggaggtat cttgctacct
88741 gacttcaaac tatactgtag ggctacagta accaaaacag catggtactg gtaccaaaac
88801 agatatatag acctatggaa gagaacagag gcctcagaaa taatgtcaca catctacaac
88861 catctggtct ttgacaaacc tgacaaaaac aggcaatggg gaaaggattc cctatttaat
88921 aaatggtgtt gggaaaactg gctatccata tgcagaaaac tgaaactgga ccccttcctt
88981 acatcttaga caaaaattaa ctcaagatgg attaaagact taaatgtaag acctaaagcc
89041 ataaaaattc tacaagaaaa cctgggcaat accattcagg acataggcat gggcaaagac
89101 ttcttgacta aaacaccaaa agcaatggYa acaaaagcca aaattgacaa atggaatcta
89161 attaaactaa agagcttctg acagcaaaag aaactatcat cagaatgaac aggcaaccta
89221 cagaatggga gaaaattttt gcaatctatc catctgacaa agggctaata tccagaatct
89281 acaaagagct taaacaaatt tacaagaaaa aaaaaacaac cccatcaaca agtgggtgaa
89341 ggatatgaac agacacttct caaaaaaaga catttatgtg gccaataaac atgaaaaaaa
89401 gctcatcatc gctggtcatt agagaaatgc aaatcaaaac cacaatgaga taccatctca
89461 caccaattag aatggtgatc attaaaaagt caggcaacaa cagatgctgg agaggatgtg
89521 gagaaacagg aatgctttta ccctgttggt gggagYgtag atgaggccag aagagttttg
89581 agttgcatgc tagaaatata aacattaagg gtggttctgg catggaaata gggaacatgt
89641 tattggaaac tggaagaaac gcaattcttg ttataaagtg gcaaagtact tggctgaact
89701 aYgttctggt gttttgtgtg aggtaaaact tgtaagcaat gaaactggat atttagctga
89761 ggagattgct aagcaaagtg tttgaaggag aagcctagtt tattctgact gcttataata
89821 aaatgcaaaa agagaaacat gaattgaaga atgaattttt aagcaaaaca ttttggaaaa
89881 ttctcaacct aacattattg caaagaagaa gaaagcttgt tctgaagaga acactaaggg
89941 tgtggctaaa caaccatttg aaaaagatca tgggtgcaac tcatggactt aatcagccat
90001 ctcaacagag gctgggaata cagattggat tatgccatca gagatactgc cagtttgaag
90061 taaaggagac agaaaaggta gtagagaatg gaggaaggct gtcagacttt ttggatttta
90121 caggatgaaa ccatagagta tttcgctttg aacgtgtgct acctttcaag aacagagaag
90181 gaacccaagg atgattcaga agtccttagg actgccactc tcaccatggt ccRggcccag
90241 tgggacaggc tgcctccacc tcagtttcaa agggtagtgc tgtgcccagc agatcatgga
90301 tggggacttt ctgagaattc aatggatgga gcttccccct accctcagct gaggtaataa
90361 ggctaccccc acagaactga aggggttggg ccacccacag agctgggggg tgacaatgcc
90421 actccaatgc acctcgaaag ggcagaacat caaagcaaag cggataattc ttgaacttta
90481 agacctaatg gaatttgtct tgctaagttt ggacttgcta tcaccctttc ttcttttgta
90541 ttctcccttt tggaatggga atgcctatcc tatgcctgcc ccaccattgt aatttggaag
90601 catgtaatgt gtctggtttc acaggctcat cactagaaag gatttttttt tttgcttcag
90661 gatgaattat acctcaagtg ttacccatat ttgatttaga tactatttag atgagacttc
90721 agacttaaga actgatgcta caatgagtta agactttagg gctattggaa tggagcgagt
90781 atatattttg catatgagaa gaaaatgaat ttttggagtc caggggtgga atgttacagg
90841 ttcaatgttt atgcctcaac ccctctgcca tttatatatt gaggccctaa ctcccaacgt
90901 gatggaattt ggaaaatggg gcctttggaa ggtaattagg attagatgag gttgtgtggg
90961 tggagccctg taagaagaga catcagggag cttgcttgct gtctctctct tcctgcacat
91021 atgtatacaa agaagaagtc atgtgagcac atggtgtgat ggcggccacc tacaagccac
91081 aagaggagaa ctcagaatga aacctacctt accagcacct taatcttgga gttcacccga
91141 ctccataact gtgagaaata aacttctttc ttttaagcca tctagtctat ggtattttgt 91201 tatggcattc tgagctaaga caggagttaa tatttattaa ataccaacta tgtgctaggc
91261 actgtgcctc atttaatttt aaaacaaaac taggaagtag gttttagtat ttccaatttg
91321 cctgtgaaga aaataaagct cagcatcaca aaactagtaa gtgatggcag atattatcac
91381 attgccttcc actccaaaga agctgaactg atttattctc tcaccaacaa tcccctcccc
91441 acacacttac caaccttgat aactaacccc caatacatag atatgtttta ttgttagggt
91501 ttgatttcat ttctcccttt ttcaagctaa tgattaaaaa tgactgacaa cttctgaact
91561 tggtacaaaa tattgtcttt gatataatat gagcaggtat acatctacgt tactttttga
91621 atggctatat tttatattat tgcatatatg taaaatcttg ttgtgactat ttattcaaca
91681 aacccctatg ccccataaaa cacttttaag ttgtatcaag tccttctctg ttaaagaaaa
91741 gcaacaacaa tttttaaaag atgcttcaat aaacagccag tatacctatc tttgtggtta
91801 tgtgtaagtc gattggtagg atatagtccc aggagtagaa gtgatgttca gaagacatac
91861 aaatttttta tcttacgtag tcttctctac taaaaaaatt tattctgtgt tttcttctag
91921 ttcttctatg atttcatttt tttacattta tttcttggat tcatctgaag tttattttgg
91981 catcaatagt agtgaaagtt tgaaccttag taatttttac taatgccatt tattgacaaa
92041 tcaattttca acattgattt gaaatgctgc ttttattgca taaaaaatcc ttatatatac
92101 tgatcatctt ctggactatc aattctattt tgttgatcta gttttctaat ttcaaattat
92161 ttaatatccc catagcagca tgctaaaatg caaaggccct agaatgaggg tgactgaggt
92221 caaatcctaa ctctcccatt tatgaaatat gtgactttag cctagcccct aaagtgtatt
92281 tgttcttcag cttcctcatc tctaaaaaga taaaatgtca aactagtatt gcctaatgac
92341 tccttcccta agccaaaatc ttgagatgga cagaagagag gaaggggttg aaggaactcc
92401 ccttaagaaa ccatactcag aaagtcacac atacacacac aaacccatga ggattcatgg
92461 ggaagcagaa gagtgctggg gacttatata ggtaggaagt ggtgaattgg aaagggaagg
92521 catcaggggg aacttttagg aaataacttg agaaaaggag gttctagttt taccctgtta
92581 ttgcccacat tgttctgggg gagttgagct cagaggtgag attagggaaa ctgaaactgg
92641 tttggaactg agtgatgtgt tcctagtaca ctgtaaaatt tggctgaagc ttgccttttg
92701 ggtgaatatc agaggatact cagagcccca caaaatagcg gtctcaaaac ccaaaacaaa
92761 taataatgca actgaaggaa tatacactaa tgatgaagct aggactccca ggttcaccct
92821 ttccctactg ttctcccaag gaggaaggta gtagtaccag cttgagcctc aggataacat
92881 cacacaccac agtactgaag gctgtcatgg acgacagcct ccactaagac aggtgaaata
92941 tcaaggttag ctggcaagtg gctgagttgg tatttgaaca tggtctctga ttacaaaacc
93001 catgttcttc ctacgaagta atttttctcc attgggggaa ttcttcaata atgacaacaR
93061 tgacaatttt cctcttgtca ttcaatatag aacactattg gatcctaaat ttcttttagt
93121 ataatgatta taataataac aataaaaaac taaacaggag aatcgcttga acctgggagg
93181 tggaggttgc agtgagccaa gatctctcca ttgcactcca gcctgggcaa caagagcaaa
93241 actccgtctc aatataaacg aataaataaa taaatacata aataaaaata aaagtgtttt
93301 ttcaaaggta cagaatgtta agagagggat atttagttgc ttgacatttt ctcgtcttgg
93361 cttttattcc tagaatctga cagattacaa gagactttga actggcttca aggatctcct
93421 tagccttact gatcctaaac tcaccacaag agatgtgatt atgactgtgt cattctttta
93481 attcaattca gaatccccag tggttacccg ctgactatag gccagattcc tcattatgaa
93541 tgctattttg tgctcattat ccaggaaggg gttataagat attagaagga ttcttgaggc
93601 attgttcctt ttagtgtaag gttaaggggt taattgaaca tcggataatc tctgaggtcc
93661 gactcaaact aaagttttca agtccctata ccaataggct tcaaattatc tcctaagcct
93721 cgtcttctct aactccttga tataaaccta tctttatttt ttatgtactt ataatttttt
93781 ccattagaaa tggaatcagt tcagaatgca taaagcttga tatttaagag ctcaagatca
93841 atgaagcctt ttccttctgc ttcagtgaat ttattaattc agctcttcat gttccataaa
93901 ttgtcactga tttagtaatt tgatgaaaac atttatatac aaatattcca taaaatataa
93961 agcctataga taccaagaag tttactcagc catagataga gtcttagaat aaaacactct
94021 gaatacacac aaatgaataa gatataagaa tataatagaa aagcacttat actggaggag
94081 tttgatgata tatgtccctg gagacaaaat tgtattagaa tcaccttctc tccatcctgt
94141 tttatttcaa agacctttca tatagtacat tgcttttatg tttagagttt atgcctaaat
94201 ttaactccat tattctttta gttactttac tatttatttg tttaaaaaaa gatttgaaat
94261 gctggcgtac aataaactat tgcaaagctt cacaaagttc taaactctcc tggactcttt
94321 agtaactgag ttatcctaga tagttgcttt ctatgtagct attcttttta agaagagcat
94381 tttaaaataa tttttgtcat tccaaaagaa atttttccat aatgagggca tcctcatcag
94441 aggataatga acatagtatt ttagttatga ttaagatcat cgctaatctt ttccctttct
94501 tcagcagcat ttattgagca gatattgggt gaagttgact atacagagtc tgtataggac
94561 aggagtgctt tcattttcat tcattccaaa ataatttgaa acttcaattt tgttatttcc
94621 ttatccaatg aattatttag aagtgacata aaatatctag ctgtctgggt tcttttttaa
94681 aaaaatttct aattttaaca tattgtgctt agttaagtag tttatatata catatttaaa
94741 attttgctgt aatttcctta gtggcttcta taagagcaNt tttttttggt acatgttatc
94801 aagtaaactg tgtattctca gttaggtgta agttctatgt atatctatta ggataacctt
94861 gttaatttta tatttaaata ctctatattt ttattcatag tatatcatag tagcagactg
94921 taacagacca ctatgatgtg atgtgtattt gttaattttc ttttgtgatt ttactaactt
94981 tttaggtatt tcaaaatgat attgaggcat tttaggttca tgatcattat atcttgctgg
95041 taaattattt gacaatatga aatgtcctgt tttgatactt ttaatgcttt gactttcaat 95101 tctattttgt ctgatactga tgttgctgtt cccatcctac tgttagtacc tgccaggtgt
95161 aggctttcaa acttggaatc atcatggttt tggctctctc cagtaagcag cacttagccg
95221 gagtcttaaa aatccaacct gatattttac cttttatgaa acaaatttac cccattcata
95281 tttatttatt tatttatttt gtgagacaga gtctctctct gttgcccagg ctggagtgca
95341 gtggcacgat ctcggcgcac tgcagcYtct gcctcctggg ttcaagccat atttatggtt
95401 attaaaaata tatatttaaa cctactcctg ccatcttatt ttgtgttttc attttaacct
95461 tcctttcttt cttgttttct tgtttcccct tcccagcctt ttcagggatt aatgaaattt
95521 tctttgttcc acttttcatg tactgttttg aaaactatat tctatcttta ttcttccagt
95581 ggttatatta actttttagt cacaagtggt tgaatttgta ttttctaata gtatctataa
95641 tcactgtcca ttgtcccctt ttgatgaacc ttagaatgct tttttcccta aattcttcat
95701 cagcacctac acttctattt tccacaaccc atgttgaaat aacctggaat ttttggcaca
95761 gagtatttat taaatatagt tttgcaatta tatttcatag aaaaatagat ttttggcttt
95821 ctttgctaac cactgcagct cctYgtgagg tcctggattc attttctttg tgtattctct
95881 agtagtagtt tcagctttca gagagattct gctgtgttat taaaactctg aattggggcc
95941 cRgcgcggtg gctcatgcct ataatcccag cactctggga ggccgaggtg ggtggatcac
96001 gaggtcagga gatcgagatc atcctggcta acatggcgaa accccgtttc tactaaaaat
96061 acaaaaaaat tagccaggcg tggtggtggg cgcctgtagt cccagctact ggggaggctg
96121 aggcaggaga atggcgtgaa cccgggaggc agagcttgca gtgagccgag atcgcgccac
96181 tgcactccag cctgggcaac tgagcaagac tccatctcaa aaaaaataaa taaataaaaa
96241 taaaaaataa aaaaaaataa aactctgaat ccctggatgt ttgaaaaaca tcttatttct
96301 tcctcacata ttaatgatat tttggctgac aatagaaatt tggatttgaa cttcttctta
96361 ttcagcaaac tgaaggtatt gctccaatgt cttttcttca tccaatatta tctatgaaaa
96421 atctatgcca aatttgatta gaattactat aaacaatctt tttttcactc tctctgaaat
96481 cttcaatagt tactctttat acttatagct tttaacatat tgactatatc cttaatgctc
96541 tgaattctca ttacatttgt acagatgtgg ggccttttgt ttttgtgatg tgtttgtttg
96601 tttaaatcct gctctgtggt tggtgaactg tttccatttg agggcttata tttttcttca
96661 cttataagaa attccatcct attatttctt cagattttac ttcccttcta ttttctttat
96721 tagctattag ctagaagtta tgacttaaca gaactctctt ccatgtcttt taagttttca
96781 acttttttta tcaccttgtg ctacattcct acgttctgtc ttctatatat caaattccct
96841 tttcagctgt tctcattttt ctatttgcat ctactgaatt tttYatttta ataattacat
96901 tttttaaaat ttccagggtt tgactttggt ttgttttRtc acagatagct ccttattcgt
96961 tattttgatg ccatactata tttgaagaca ctaattaagc ttcttaagaa aagtcctttt
97021 cttatcatct attaaatttt tcaaagttgt aattctgttg ggctgttata tatatttttt
97081 tatggaggct gcatgctaaa tattgttgat tcttgactgt aggctcatct tggtgatttg
97141 aattccccgc tagactcctt atgctttcac tcccacagcc agccttaggg gaggtataga
97201 aacagctttt gaggtttgtg ctcctcactg ttttcagtga gaatgaggga aagttgagat
97261 gggtattgct gaccctgccc ctcattctta ggctggctcc tatgcagaga cagacttgaa
97321 ctggtagaga ggtaaagagt gggatgtaca tggcatgacc agagtggatg cctcaactca
97381 ttttcttatg atttgcctta gcttccacct cctgtctagt cctaccttct accatgtcta
97441 agcatgggca cccttggtga tgctcccgtc ttctgtggca ggactttcta aaagtttcca
97501 gtacaaactc cagactacaa ttactctctg caaacagcct gtgtactttt agactttctg
97561 ggatttctca tcattttgat tagccaaaaa tctctttgaa tttagaaaac aagctataca
97621 ttcataKact taaaaaataa cttaaggctt agagtggaag gacagaagct gagaaaggag
97681 aggatatcat cgtgcaatta gtgttccatc ttgaaagtga aagcctccat ttatattttg
97741 tgttgtttcc cttttgtatt gatattaggg atactaRgca attgtcacct actttgcaaa
97801 tacttgttac atgtgccttt aaatttcatt tcaggtatct tcagagacac agatgtttta
97861 cattttaatg Mggacaaatc tgttcatttt tcactttaag atttctggtt gttgtgtcat
97921 gctcatgagg cctttttact ccacaatttt aaaagtttcc tgtattacct tctgaaattt
97981 catggttcac tctttcatat ttagatattt catgttcaga tatagatcta tgaggacttt
98041 agttttcggt ttgaggtgag gtttcgtgtg ttttccattc tcccttttct atataggagt
98101 ttttattgca gctgttctac tgctccacta atttgttttg ggtgggtaga tgtagaagag
98161 catttaacat gtttacttga tagttcatca aatcataaca aaccacatcc atatttgatg
98221 tacgggaatg tgcagccctg agttcttgac ttttgagatg agttcagtaa ctgcctgggg
98281 tttggggtca tctccctttg gggaaagatg agtgtgaaga agagtatgtg aagatatata
98341 gtagccagag aagctgactg tggcagagag cacaaagtgt ccaccaaaac aatcttccag
98401 ttctcccttc gggcacacag ctagagtcca tctccctgtc tccttcagtt aggtagagcc
98461 aggcgactaa gttctttttg gtgcagtgtc aacagccatg cttgccacgc ccatagaagc
98521 cttcgtatgt acttcatcct ttttgaaggc tggatgtagt tgaaaagttt ctaagagacg
98581 gggccaggag atgccagggt tcttaaagac atgaaagact gcatggggga cttgaaagtt
98641 gcctgctgaa tgttttgcct tgaacttaca ctcaagtgag aaataagctt ctgaaagtat
98701 cagtttgctt tagttttttt tttttttttt tttttttttg agataRaatc tcgctctgtc
98761 tcccaggctg gagtgcagtg gtgcgatctg ggctcactgc aagctccgcc tccagggttc
98821 acgccattct cctgcctcag cctcccgagg agcggggact acaggcgccc gccaccaagc
98881 gcggctaact ttttgtattt ttggtataga cggggtttca ccgtgttagc caggatagtc
98941 tcgatctcct gacctcgtga tccgcccgcc tcggcctccc aaagtggtgg gattacaggc 99001 gtcagccacc gcgcccggcc cgagatatgc tttttgagtt aagaagattc cttttatttc
99061 taacttaccc agtggctttg ttgttgtttt aatcagaaat gagtgttaaa ttttattgaa
99121 gattttcaca cctgttaact atatcatata gctgttcccc ttaaatcttc ctatgtaata
99181 aattccaatt attacattaa tagagtcctt aaagtagaac tatatttaaa tatgaccgta
99241 agatggtatt cttttaatgc aatgctggac ttcattttgt ttataatttt tgtgtatgtt
99301 caagtgtttc attgatttat agttttcttt tttatcctat ctttgtccag ttttgtcact
99361 gagtttatgc tagatgcaaa ctgagaagtt tatcagcttt ttctttaatc tttaacaatt
99421 tatatatcat gagttatcag ggcctcatgc cctttgaagg acatgtatat atatatatat
99481 atatttacta tggttctaat ttcctctagt gttatggatc tattcattct tttcattaaa
99541 atttgtaata tttgttatgt cccctcttct aatttaattt ttgttaaatt ttattaaatt
99601 ttcagtggtt atatcagttt ttaaattcct gccatgcact gctcttattg attacagttt
99661 ctRagggctc atgtattgtc aaagaatgtg agttttgatt tcacaatttt accattttct
99721 aacttattta tttttgcttt tatttttatt tctttcttct gctttccttg attttatttt
99781 gtttttccct ttctaatact tcgagggttg ttaatttttt tgtttaatta gaaggcattt
99841 ggggctataa agttttctat atttcacaag ttttgattaa taatatcttg ttctaatgtt
IL1RL2 genomic sequence ("SEQ ID NO: 3)
>2 : 102409301- 10250 5350
1 ttgtgttcat caataggaaa tagttaatca tagtgtatat gtattatgga atgctaagca
61 gccatgacag agtctatttt ggaagacaaa tcatgtgggc ccaaattccc aatccacagt
121 aattacaaaa tagtaggcaa aaagacccca tttcaaaaac tgcacatgtt cacagagaag
181 ataaggaatg agacgcataa ggttactaat ggtggttttc tctgKgtggt gggtttaggg
241 taattttcct ttttctttgt gcatttctat atctaaaatt ttaattcaat agccatttat
301 taatctagat agatcagaaa aaatcaatta atgttaagat taaaaataca ttctttgcag
361 gatcccagat acaattgatc tgtaatgtca ccggccagtt gagtgacatt gcttactgga
421 agtggaatgg gtcagtaatt gatgaagatg acccagtgct aggggaagac tattacaggt
481 atgtatgcta agagttattc acattttgRt gttaaatccc acgtgatatt ttatataacc
541 ttgtcggttc agtttaaaag caagtgttag ttgctcctaa cctttgctgc cttttttttt
601 tttttttttt ttttttgcta agctaagtag aatttataag atcttgtaca tttaaggtaa
661 aaaatacttg tcattgtggt gcaaattaca gaccacttag aagcctttct cttacgttat
721 acatgttgca acatttcaac gaagcaatta tctttcatta ttcttcatat tcctcaagta
781 gcttagaaga gactcattaa tgagctcaag aatcaggcaa tccactgctc tcgaaagcct
841 ctactggttt cctactgctY atctatggga caaRgatctc ctggcttccc atgacctctc
901 cttcacaaca cctgcaaagc actttgtcat ctgccccaRt ctcctcttgt ttagtgtctc
961 ctctgtgccc catggagaac acaatgcatt tgtctacatt tttcttcttg gaagtggtaa
1021 tttttttgct ttctctgcta ctgagcctgt tactgacagt ggtcttgggg ttataaaatc
1081 tcagattagt gttgccagca gtctgaatgt tgtgactgtg attgggcagg gtgattattt
1141 cagtggcaat tttgtcacaa ataaggaaat acacagggta tacaggtctt atttgtagtt
1201 gatgcaatta acttacacaa gtttatttac tctctctctc gaatagtgtg gaaaatcctg
1261 caaacaaaag aaggagtacc ctcatcacag tgcttaatat atcggaaatt gaaagtagat
1321 tttataaaca tccatttacc tgttttgcca agaatacaca tggtatagat gcagcatata
1381 tccagttaat atatccaggt aaacaacaaa ctaattgaaa tgcagttttg ttttactgta
1441 gtaagattcc atgactttga agtttgaaat gccatttcct ctKcttagaa cacgcttcac
1501 ttcctcatta cttgggtaac ttctatttct cttttactct tctgctgaac tctctcttct
1561 tggaagcttt tctgtcctgc tgcctgccct taacccagct ctcggcccaa agagaggagg
1621 ttagggcctc tgtatgtact tctgtagcac catatgtcac aggatctatg gtacttcgtt
1681 ttctgtactt aactataaat tctgtgatgg tggcaaccat ttatcttagt aatcattcta
1741 tttccacagc taatggcaag ttaggtctgg tacattgtgg gtacccaatg aactacaYtg
1801 atgatgcata gggtaagact aaatatccac tttcaaagag gacatcagaa gtcactgggt
1861 ttcatgaatt ggtataataa aacataatat tgaaagtatt tgtgaaacat tttaaggtaa
1921 tttgtggttt aattaaacat aggctattat aattgcgtgc atggaagaat atctgaaaga
1981 ctctataaat taacttctat gtatgtttaa atactggcag catacaaata gaaattacat
2041 ttaaaagata acatttatgg tagcatcaaa aatcatcaaa tacttaagaa taaatctagc
2101 aaaagctgtt caaaacctct gtaatacaaa ctaaaaaata ttgagataaa ttagagaaga
2161 actaaatgga aggatataca atgttcat g attgaaagac tcgatattat gaagRtatca
2221 gttcttcccc aaatgaatct atggattcca aaaaatttca atcaaaatct cagcagtatt
2281 tStacaagtg agagtcagtg tttgtatggg tgtgtttttg tggacacctg taaaagtcaY
2341 agggaactgt aaaggaccaa gtatagtcat ggtggtctta aataagaaaa ataaatctgg
2401 aggattatta ctacagacat catgatcttg tatgaagcga cagtacttaa gaccgtaagt
2461 gtgaactatc atttgggcca gctggatatt tgtctggaaa atggtataac ttgatttctg
2521 ttttatatcc aaatcattta aattggaaaa gtaaataaag cttttagatt cccttttctg
2581 gatgctttta catggttcct gatatttaga gggtactttc tttttcttcc ctctttcttc 2641 ttctctagcc ccctccccat cacctactcc atctgctccc cagcttcctc tttaattatt
2701 ggataactaa gtagagaagg aggccaggag aatgtggaaa tgtgaaactt ccctaagcct
2761 ccaccttatt cgctttccac cagtctttaa ctttacccaa tggactctct gacctcaggg
2821 aacttttgta ggcttttgag tgattttaac ttttccctgt tttactgtgg aatgctctat
2881 cctgtggtct tcggtattat ttcccatgtt attgtatatt atgctattta ggtagaaact
2941 tcatagaatg caccttagtt ttMtcattgc tttgtacatt agtatccatt acaaagtgat
3001 aataatgaat gagttaatat tgtctgaatg caggccattc ccagatatgg gctctctgag
3061 acgaagatat ttaatttgct gtgctcaaag ttttaattct ttttggttct aatatttttt
3121 ctcctttttt tttctttttg ctatagtcac taatttccag aagcacatga ttggtatatg
3181 tgtcacgttg acagtcataa ttgtgtgttc tgttttcatc tataaaatct tcaagattga
3241 cattgtgctt tggtacaggg attcctgcta tgattttctc ccaataaaag gtataatttt
3301 gtattccatg cagtatttct tgttggagat aagggatagt taggagatgt agaagatgac
3361 taagagggNt tttactaaga gggtttctaa aatgaaaagt ggcatataca agaatactag
3421 ttattcttac acagaattat agttttagaa ctcattaggc tgaatatcat tgttttctaa
3481 Rttcctgcct caacattcat attggtagaa taaacaggta tttagagcat ctgtttataa
3541 attcagttat gcacaagcca ttgKtaggcc ttgctctgtg atgaatagga cagacagaga
3601 tcatacctta atgaaagaaa tgaaatgact agatcttcat gcatcaggga ggNtctctct
3661 ctcctttgtt taaactttgc gaaaaaaaaa aaaggaatac cacaatatct aaaaaaaaat
3721 gaatggatag aattcagggc tgagacctct ggggaagaag atgaggacag ggagacttta
3781 aggatggctc tatactaaga gtatacgagg cagcctccaa atagaagaac aaatttgcag
3841 taaaacacaa gaaatagaaa ccttgtaaga gatgaacact ttttaaaggg attatatttt
3901 tggtattgct gcttcagtca tgccattgta taaaaaaaga tgaatagttc attatgtaat
3961 gaatgtttgt gatactgact ttatcaaatc tcttattttt gccttgtggt tctaaataca 4021 ttatgttttt cctttagctt cagatggaaa gacctatgac gcatatatac tgtatccaaa 4081 gactgttggg gaagggtcta cctctgactg tgatattttt gtgtttaaag tcttgcctga 4141 ggtcttggaa aaacagtgtg gatataagct gttcatttat ggaagggatg actacgttgg 4201 ggaaggtatg tgtgtaatgg aacagagtaa aggcttattg ttgtaaaact acttagtaaa 4261 atgtggattc catctttcta gaagatcgtg gcataggggt atatgtttca caattttaag 4321 aacctcttca gaagtgtatg atgattttta catttattaa atgcatttac ttctctcata 4381 ttttgtcaga gcaataatta agtgattttc atttagtttt gaaaaactta atgactagtt 4441 aaacccaaca gttgctttac aactgataca attaaacagg agtggtagag atcaaatgat 4501 tgaataataa gtttttaaaa ttccaacaaa gttttctgag ttctaaatga aatatttgtc 4561 ttttgagggc caatttttga gttagtctat aaaatgggag gtttgcagtg gctcatgcct
4621 tttatctcag tacaaccctg ggaggccagg gtgagagggt cacttgagcc taggagtttg 4681 aggctgcagt gatccaagat cacgccactg cgctccagtg tgagcaacag aacaagagac 4741 tgtctcttaa aattaattaa ttaaaaacat gggaaactcc tttaatttta agtaagacaa 4801 gaaaaaggca ttaggagcca tacggttgtg aaaagccttg tgtggctttg gttcaggagR 4861 gaatgatgat aaatagaatt ttacttacta tattgtgctt cctgtttttc agacattgtt 4921 gaggtcatta atgaaaacgt aagaaaagc agaagactga ttatcatttt agtcMgagaa 4981 acatcaggct tcagctggct gggtggttca tctgaagagc aaatagccat gtataatgct 5041 cttgttcagg atggaattaa agttgtcctg cttgagctgg agaaaatcca agactatgag 5101 aaaatgccag aatcgattaa attcattaag cagaaacatg gggctatccg ctggtcaggg 5161 gactttacac agggaccaca gtctgcaaag acaaggttct ggaagaatgt caggtaccac 5221 atgccagtcc agcgacggtc accttcatct aaacaccagt tactgtcacc agccactaag 5281 gagaaactgc aaagagaggc tcacgtgcct ctcgggtagc Rtggagaagt tgccaagagt 5341 tctttRggtg cctcctgtct tatggcgttg caggccaggt tatgcctcat gctgacttgc 5401 agagttcatg gaatgtaact atatcatcct ttatccctga ggtcacctgg aatcagatta 5461 ttaagggaat aagccatgac gtcaatagca gcccagggca cttcagagta gagggcttgg 5521 gaagatcttt taaaaaggca Rtaggcccgg tgtggtggct cacgcctata atcccagcac 5581 tttgggaggc tgaagtgggt ggatcaccag aggtcaggag ttcgagacca gcScagccaa 5641 catggcaaaa ccccatctct actaaaaata caaaaatgag ctaggcatgg tggcacacgc 5701 ctgtaatccc agctacacct gaggctgagg caggagaatt gcttgaaccg gggagacgga 5761 ggttgcagtg agccgagttt gggccactgc actctagcct ggcaacagag caagactccg 5821 tctcaaaaaa agggcaataa atgccctctc tgaatgtttg aactgccaag aaaaggcatg 5881 gagacagcga actagaagaa agggcaagaa ggaaatagcc accgtctaca gatggcttag 5941 ttaagtcatc cacagcccaa gggcggggct atgccttgtc tggggaccct gtagagtcac 6001 tgacccKgga gcggctctcc tgagaggtgc tgcaggcaaa gtgagactga cacctcactg 6061 aggaagggag acatattctt ggagaacttt ccatctgctt gtattttcca tacacatccc 6121 cagccagaag ttagtgtccg aagaccgaat tttattttac agagcttgaa aactcacttc 6181 aatgaacaaa gggattctcc aggattccaa agttttgaag tcatcttagc tttccacagg 6241 agggagagaa cttaaaaaag caacagtagc agggaattga tccacttctt aatgctttcc 6301 tccctggcat gaccatSctg tcctttgtta ttatcctgca ttttacgtct ttggaggaac 6361 agctccctag tggcttcYtc cRtctgcaat gtcccttgca cagcccacac atgaaccatc 6421 cttccYatga tgccgctctt ctgtcatccc gctcctgctg aaacacctcc caggggctSc 6481 acctgttcag gagctgaagc ccatgctttc ccaccagcat gtcactccca gaccacctcc 6541 ctgccctgtc ctccagcttc ccctcgctgt cctgctgtgt gaattcccag gttggcctgg
6601 tggccatgtc gcctgccccc agcactcctc tgtctctgct Yttgcctgca cccttcctcc
6661 tcctttgcct aggaggcctt ctcgcatttt ctctagctga tcRgRatttt accaaaattc
6721 agaacatcct ccaattccac agtctctggg agactttccc taagaggcga cttcctctcc
6781 agccttctct ctctggtcag gcccactgca gagatggtgg tgagcacatc tgggaggctg
6841 gtctccctcc agctggaatt gctgctctct gagggagagg ctgtggtggc tgtctctgtc
6901 cctcactgcc ttccaggagc aatttgcaca tgtaacatag atttatgtaa tgctttatgt
6961 ttaaaaacat tccccaatta tcttatttaa tttttgcaat tattctaatt ttatatatag
7021 agaaagtgac ctatttttta aaaaaatcac actctaagtt ctattgaacc taggacttga
7081 gcctccattt ctggcttcta gtctggtgtt ctgagtactt gatttcaggt caataacggt
7141 cccccctcac tccacactgg cacgtttgtg agaagaaatg acattttgct aggaagtgac
7201 cgagtctagg aatgctttta ttcaagacac caaattccaa acttctaaat gttggaattt
7261 tcaaaaattg tgtttagatt ttatgaaaaa ctcttctact ttcatctatt ctttccctag
7321 aggcaaacat ttcttaaaat gtttcatttt cattaaaaat gaaagccaaa tttatatgcc
7381 accgattgca ggacacaagc acagttttaa gagttgtatg aacatggaga ggacttttgg
7441 tttttatatt tctcgtattt aatatgggtg aacaccaact tttatttgga ataataattt
7501 tcctcctaaa caaaaacaca ttgagtttaa gtctctgact cttgcctttc cacctgcttt
7561 ctcctgggcc cgctttgcct gcttgaagga acagtgctgt tctggagctg ctgttccaac
7621 agacagggcc tagctttcat ttgacacaca gactacagcc agaagcccat ggagcaggga
7681 tgtcacgtct tgaaaagcct attagatgtt ttacaaattt aattttgcag attattttag
7741 tctgtcatcc agaaaatgtg tcagcatgca tagtgctaag aaagcaagcc aatttggaaa
7801 cttaggttag tgacaaaatt ggccagagag tgggggtgat gatgaccaag aattacaagt
7861 agaatggcag ctggaattta aggagggaca agaatcaatg gataagcgtg ggtggaggaa
7921 gatccaaaca gaaaagtgca aagttattcc ccatcttcca agKgttgaat tctggaggaa
7981 gaagacacat tcctagttcc ccgtgaactt cctttgactt attgtcccca ctaaaacaaa
8041 acaaaaaact tttaatgcct tccacattaa ttagattttc ttgcagtttt tttatggcat
8101 ttttttaaag atgccctaag tgttgaagaa gagtttgcaa atgcaacaaa atatttaatt
8161 accggttgtt aaaactggtt tagcacaatt tatattttcc ctctcttgcc tttcttattt
8221 gcaataaaag gtattgagcc attttttaaa tgacattttt gataaattat gtttgtacta
8281 gttgatgaag gagttttttt taacctgttt atataatttt gcagcagaag ccaaattttt
8341 tgtatattaa agcaccaaat tcatgtacag catgcatcac ggatcaatag actgtactta
8401 ttttccaata aaattttcaa actttgtact gttatcctga gaatctgttc tttgtccagt
8461 ccacagctta cctgcacatt tgcacattcc caggcctcaa caaggtgagg agaccttctg
8521 cagaKWgttc ttcctgttgt ggggaagcag gtggggagga gctggaggag gggaggggag
8581 tggaggtcag aggctatYgg cttaacagtg agccctaact ccc tcttct agctaaactc
8641 tactccctct gctcatttgc ttctaaaatg gattaaaatg tgagccttgt caataactgt
8701 ttattaactt cttatcaatt tactattaac ttatcacttt acctgtccaa aaaatgataa
8761 agggaatatt tgtatagact tttacatttt acaaagcgct tttatttttt cctttgaccc
8821 agaaggtggg caaaattggt gaacttgctg tccaaaatgc atgctctaaa gcttgttaac
8881 tc gatggtc agagatgaca cccagtcagt gcctccttct tacctcacag caatgctaag
8941 gggcaggtga ctctctcagt acctggggag aaggggcagK tggcaggttg gcttagagtc
9001 tgagtccagt atgagcactg cctccaccag ctacctggag tgaaacctta ggcaaagtat
9061 ttgagcctca atttactcat tatataggta taatatctaa ctcatagagt taagattaaa
9121 aagattaaat atattatgac aagcctagtg cttagcataa agcaggttct cagaaaatgg
9181 ttgctttgtt agtagcaatt ctatgaattg cttatctgaa gccctattag aatctgcaaa
9241 tggaaggggt agagaggact tataaattag aaatgacaat tgacactaag gacaaagtac
9301 acaatgtcaa actgaagttg tataaccaca gaggccagga gccctgtcca gcccacagcc
9361 cctccactgg cccccaacct gaaagaatgt ttctcactgg aagagttcag ggagctttgc
9421 accacatttt ggttatgata ccagttaatg tgaaaaccat taggaaaatc agtgctaacc
9481 accatttaaa actcacacgt tttcctctct ttatcagata aattttcccc agtaaatgca
9541 aaataggttt ttagggagtc tctggaatta ttttacaaca ggaatgccgt ctggtggaaa
9601 aagacctgga actaaattcc tgcactgtca cagctttgaa accacaacaa agcacctggt
9661 tgtatggaac ccccattttc tcatgtgtaa aacaggactt cctatgttac aagatgttta
9721 tatgtaggaa gtctctgtcc agtatacggg atagaatctc aaaatatatt ttcttagttt
9781 tatcacttga tgagtacaga taaaacaaaa aacttactca tccaaaatgt atatttttca
9841 aattctaggg ttttaggtgt gtgcgggggt tggagagtga tataatgctg gtgttaactt
9901 tttaaaatga tcacagctgc tacttaatcc cattttagca agtcaggatc tggtttagca
9961 tttttaatat agtacgttcc ccaagtagta attgaaggac ttctaagtat aaataccatg
10021 caattataaa atcagagatt tcctccagct tatttgtcaa aagaaaatct tttcgccttt
10081 gacgtgaggc tctgggagtg tggtgaggtt ggcttagcgt gcagggcata gggagcgtag
10141 caggtgggga agaatgtgga ttgggctgga agggaaaaat tgttcctctg ttactaaaat
10201 aaaatacatg aatgaatcac catcatggca ataattcata aaatggagta cacatgaaaa
10261 aatgtatgtg ggaagacaga ggaaagggat aattttttga tgtgataaca ttcattttac
10321 aaccaaagat tgtgtgtgtg tgtgtggggg ggggcggggt gtttaaattt taaggagagg
10381 aagagttaca ggaataggtg gtactattta aaatgagtat taatcattca aaacaaaaac 10441 atgctcatct taccacatgc cgctcaggtt tcttctgaag aaggcttggc tgctcaaagt
10501 acgtaaatca tacctatacc ttaaatctga gccccaaaca ttagcacagc agtctctcaa
10561 aatttgcagc tgttagacca gttgagcctg taccacctga ctctagactc ataggaggct
10621 gttgacatct ctaaagctgt gttcaaccag ttgagagatt aatttaccta cagggtgaag
10681 ttgatgaagc ttgtttttct tagaaccttt gacctggaag tgatcccaag tgccatttgg
10741 cttctgcttc cgggtctggg aaggctacaa tgataccatt ctacagtgtt cattggtttt
10801 cctgtcaatc tacacatcct gaggatgaga ttccttaggc ttctttagtg aaacggtatt
10861 gcatgtttca cagcctgtgt ggggacccac tcctgctttg gttcatgtag ttaatccttc
10921 cctggctaac actacatttt ccctccacag ccatgttacg tcacttaccc tgcttagcca
10981 gggacagact gcagcttctc atttgctttc aaggctgtag acagcagcca tctgtttcaa
11041 cagtttttgt cgtcagatgc tattccgtag tcctgccttc cacactgtac ttgattgctt
11101 ctgaattctt gtctttccta aaactggacc catgtcctct ctcaaattca aaaacacagg
11161 ggaaatattt gtgttctcaa gcgtactttt agatttttaa aaagtgctaa ccaagtggtt
11221 aacattatgc tagacactga gaaaattaca aggtaagaaa aaacagaaat ctagccagag
11281 aagaagagtg tgaagagaaa gttgttcagg aaacaatctc atatgacaga gggtcttaaa
11341 cccatgactg aactatttgg actttaccac taggagtagg tatatgggag atattggagg
11401 caacaggttg gaagaacttt cgacataaag aaacacattg atagggcact attgtacagc
11461 agattgggag gaggtaaaag gttacatagg gaggttgtta ggaaggtggt agagtaatcc
11521 ccttgggagt caattatatt taagacattt tataaaataa attaggagaa acttcttttt
11581 attacgaaag caataatggt ttgagagaat gtggaaattt ctaaaacata taaggaagaa
11641 aaatgtcacc cataacttca caacctaaag ataattattg atattttata acatttctat
11701 ggatataact gagaccatat aatacatgga gtttaacact ctttttaaaa cttagcataa
11761 atatttgccc acattactat tatacgaaat acaatctata agtagtcact aagtctatca
11821 aatggatggt ccataatctg atagctttgc tgccttcagt ggacatccag attatttcta
11881 gttttagcta tcagtagtca aagtgcaata gttatccttt ctcaaatatt tttacttccc
11941 taatcatttg cttagcatat attcagaggg caagattcct tttcaggttc ttgatgttcc
12001 atagagacat ttgctcctct tacacaagca gtgtgtggca ctgagaatac tcattattaa
12061 atcattgcta atttgataga caaaaaaagg ttatcctttg ccagttaact attaacatgg
12121 ttgaatgttt cacttaacaa ttacaattgg aggcgggtgg atcacttgaa gccaggagtt
12181 tgagaccagc ctggtcaaca tggtgaaatg aaaccccatc tctaccaaaa acacacaaaa
12241 agcaaaaaac aaaaattacc tgggcgtggt ggtgcacgcc tgtaatccca gctactaagg
12301 aggctgaggc agctgaggct attggcttcg tctgtgttat tttattttgg aatttacaaa
12361 ctgtttcctc ctttgtgatt ttgcactagc tgtttcctac tttggggaaa gcccttctcg
12421 cagacctcca catgctggac tccttgcctt gacaagggcc tctgctgcac catagtccct
12481 tctgaaggga ggacttcccc aacaccctct ccatcacttc atcataattg ctttcagggt
12541 tctcaccagc ctgaaatcat ccttcaaaat tttcttattt acttgacact agaatgactg
12601 taaactctaa gagggtctgt cttctgtaca gctgtatttc tggcactcag aatatcacct
12661 ggaacacagt gggaactgta taaatatttg atgagggact gagcgaacta atgaatggag
12721 ctcgagggag tgagtgatta agcccaggac tgcaggaaac caagtgcttt aaggacctcc
12781 ttccagtctc cctggctgct tcttccattt ctagaagtcc atttcatccc aacaatagca
12841 gtctgctaca gaaatgctgc tatatattcc caagcctcat agaggggaaa tatgagaact
12901 taagggcctt aaaggtataa agatcttggt ggagccccaa acacccaccc cagcctaata
12961 ctgggttttg gaaagtttaa ttgttgcgtg tgaatatatt tctgtttcat tctcattggg
13021 aaacattatc tgtgggatat ggccaatggg aaataatcag atatttagtt agaacaaata
13081 aaaggtagta tgcatcatgt aaaatataaa tttgtatatg aaatctttaa tccaaattgt
13141 tgccctccta cccttctgaa tagccgtcat atcctagtct gagggtcaaa tagactgaag
13201 gtaaaattca accaagcaga attctgtaat gctttcatca cacacagatt tgttgctttt
13261 tgcctgctct cagaatgaag tgatgaatct ctagaggaag ttgatttact tcataaaaaa
13321 aaaaaccaac tgaaaattat ttcctatggc cactgactaa tgctagaaaa cattaagaat
13381 attcccattg aaaaaatatc tgcaagtggg agagaattag acaaggaggg gttggtaggg
13441 ggatggtgat aagcatctat tacatattat acaccctgtt atggaggctt tacaactgcc
13501 acctctgaaa actgggcata acctctcaat ctaaatgtat ataaaataaa atcacaggat
13561 agcttttaca tcagagcMgc aaaactggca aaatttaaaa gtctgacatt accaaatatt
13621 ggtaagaaca tgaagcaatg aaattctttt cctctaaagg acatagctat ggaaaaaaat
13681 tagggctttt ctaatacaat tgaggatgta cctacccaat gattctgcaa ttccgttcac
13741 taaatggcct ctgaaatact cgcacaaaag gacattacca gaatctttgc agcagcaccg
13801 tttataagag caaaatataa atttggaaaa acttaaatgt tcgaaggaga tgaatacatt
13861 taagtttttt tttttcaagg taattgagaa cctgcagtaa atattatggt ttcctgttat
13921 ttttaattgc taagtttaca atacccggaa tcagttctgc cttcaaagcc aagtgttcat
13981 tttccacgta tcaggaaaca catttggcat agagaccatc ccaggaagtt aaatttcaga
14041 ttctcagaat tagtagcaaa gtgcaatgtc agaagtgtcc agtgagaggc actgcagggg
14101 actgggatgg cctgtcttaa cttcatacat tttggggcaa caatacccat taaacttggc
14161 atatatacta gtcctcaggc taagaaataa gataggacac aaatgcatct attcataaag
14221 tgaaaatgaa aaaagatagc ataaagattt agaaatacct ttcaacactg ctcatagaaa
14281 taattctgaa tgcaaatcat atgactttta taaaaatagt aacacttttg ttttgttttg 14341 gatgaggaca taaacgctga agaatataca tatacagagg aacctcgttt actgctgata
14401 gtaggggaaa taaataataa tctctattta tagcttaaga aagaggtcct caaagagtgg
14461 gagccctatg ggtccctgag agacccttca aaaagatctg tgaaatcaaa actatgttca
14521 tcgtaatatt aagaccttat attccttttt tattctcatt ctctcattag tgtatggtgg
14581 accttttcag aagctatatg acatattata tcatgacact gattgcagaa gcaagtatga
14641 gaatccagtc atcttctagt aagccagaca tcaaagagat ctgcatctat gtagaacaat
14701 gccgcttttc tcaataagcc tgttttagaa agtagagtta tttttcataa attgtatgat
14761 atttgcgtta acatgtaatg ggtttattgt cacttaaata agaaagtaaa cgtttaaaaa
14821 ttctcccttt aacttctaat gtagtaatat tgacaggcat aacctacata gacaaaagca
14881 ctttggaatc ctcaatactt tttaagagtg tagaaatcta caaaccactg accttcagcc
14941 tatcacagga agctttgcta ttagcacaat tattgcatct ctgctcctat ggttgctttt
15001 gtctcactgt ctctgatctt tcaaagaccg ttgggaagag cttgaccagt aatctattga
15061 atggagatta cattttgaac cttttcctac aactcagtgc cctgtgggat gactctgggg
15121 tgtctcctga tggctagggc aacaggtccc tgttgacatc accttatcgg gaagttttag
15181 acaggaacag tcttcaggct ctgaagtact tgaacaccat gggattcctg ccttacagaa
15241 gttaatgagc acgactcagg cagattcata attctcctta gaagccattt gggatggctt
15301 ccactttggg gtcattccac ataggccaat gcagagcatg cagtaactgc tcaaatagga
15361 tttggaaagg aatgaataat tcatttagac gttcaacttg gaatagactt aagcagacac
15421 tcctggtgat gaaggactta gatgccagaa aatcaggctc aaagactttc aagccacttc
15481 ctagtgtgat gtcacattcc ttcctacgct ccactgggga aggcaggtct gccccgccca
15541 cggtggcggg gaaataccta ggcatggaag tggcatgaca gggctcgtgt ccctgtcata
15601 ttttccactc tccacgaggt cctgcgcgct tcaatcctgc aggcaggtag acaccgggcc
15661 gggagtctgg ctgagccagg catgggtggg gccctgacag taggagaggt gtgcaggaaa
15721 agacgtggca acaatgtgtg ccaccgcagg ccagggatca ggccccccag gccggccccc
15781 gaccggctag gtgaccatgg gggagccgac tccgtctctg ggtcgaggag tggagctcgc
15841 ggctattttc agctccagcg gctccctgcc ttcctttctc ctttcccgct ggcccttgcc
15901 aggtaggcct gccctggctg ctccccagtg agcgggtgtt tggggtttct gtttagaccg
15961 ccaggctcgg gtggatcccg aggacacagg cgcgcagggg aggctccgtg cgccgcgagc
16021 ggggttgggg tcccacgtct ggaacccagg ccgcaggctg cgctgggggg cgccctggcc
16081 ctcacggggg ctctggacac cagcctgctt cgctgtcagg tggcagaagc agctMccacg
16141 Mggtccccac cgccgccgcc gcctactcct cgcccatcct cctctgcggc ggggcgagct
16201 ccctgccctg gatcctggtc gggcgcccag acgaaggaga caggggaagg gcagtctttg
16261 gggaaacgtg gggccaaagt cggagggctc cccaggaaaa agggaaggtc agcggcctgg
16321 gcggttgtct ttgagattcc gaggtcgccc acgccggcgc ctcgggcccg ccctactgcg
16381 tcctcccctc ccaccctctt ctcccttcct tgcagcccgg tttggggatg tggtccttgc
16441 tgctctgcgg gttgtccatc gcccttccac tgtctgtcac agcaggtacg ttccgtgtgt
16501 cctccgttcc cagaggctgc ccgagtccac aggctcctgg cctgtcattg ggagcccccg
16561 gggatcgcgt cagcccgagc gcggctcctt cccctcccca gaccgccagg cggagttccg
16621 cggaagagga aacagagaac cNgctccacg tgctcggatg ctcagccctg aatgtcgcct
16681 ttgagcttgg aggtgacttc ggggagggga aggagttagg caaattccaa gtgaagactt
16741 gagtaacaat gctcaaatgg aattactaca ggctatttta taagataaag cgttatttta
16801 tgacacaagg tgaaagcaag gaaaccgtca atagaacaaa tttcttctaa gaaatttggt
16861 atggccgggc gcagtggctc atgcctgtaa tcccagtact ttgggaggcc aaggcgggcg
16921 gatcacgagg Ycaggagatc tagaccatcc tggctaacac ggtgaaaccc cgtctctact
16981 aaaaatacat taaaaaaatt agcYgggcRY ggtggcgggc gcctgtagtc ccagctactc
17041 aagaggctga ggcaggagaa tggcgtgaac tcgggaggcg gagcttgcag tgagccgaga
17101 ttgagcctct gcactccagc ctgggcgaca gagagagact ccgtctcaaa aaaaaaaaaa
17161 aaaggaaatt tggtagaaat gaactttaaa agtgaaccaa attttttttc ttaaacaatc
17221 gttttgggat gaaatacctt ttactcaaga cagagtaaaa taactgggtg gcagagcaga
17281 aacagaaaag acaagaaggg ttgatttact ctgtaggtga gtacagagta aagaactctg
17341 tggatgaaaa gaactaaggg tcgtagaata gaagggaaag agggaaatca ctcccgatgg
17401 ggaggtttgt gaggagggaa cggagtaaat tctgttttat ggatacattt aaagaacttg
17461 gaattatact ttataatcag caggctattt ttaggaaact tccagactca agaaactccc
17521 aaataaaatt tcaaattggc tggaaaattg aagaggcatt taaaaaaact aacagtaaat
17581 aaaactgaag ttttctttca tggataattg ttttgttttg tttttctttc cctagatgga
17641 tgcaaggaca tttttatgaa aaatgagata ctttcagcaa gccagccttt tgcttttaat
17701 tgtacattcc ctcccataac atctggggaa gtcagtgtaa catggtataa aaattctagc
17761 aaaatcccag tgtccaaaat catacagtct agaattcacc aggacgagac ttggattttg
17821 tttctcccca tggaatgggg ggactcagga gtctaccaat gtgttataaa gtaagttcct
17881 aatttaaaat agaactaact cgtgtgtgta tgtataaatt attttaggaa aattcttaac
17941 gaacatagaa aactcttgag aagaattatg ttgttgtatg tttttataat tgctacaaga
18001 caatttccag tgaacacatt tttaaacaga acagatttgt aaatcatttt tggaacctga
18061 tatgcatctt tccctatgga aatggcacct cagaccagac ccactcacaa agtgtgtttg
18121 tcccagtatt attgctgcca tctttctttc ctgttttctt tttcttttct tttttatttt
18181 tcttttttat tttttgagat ggagtctcgc tccgtcacca ggctggagtg cagtggcggc 18241 gatctcggct cactgcaacc tccgcctccc aggttcaagt gattctcctg cctcagcttc
18301 cgaagtagct gggattatag gcgcttggct atatccgaag tagctgggat tataggcgca
18361 agccaccatg cttggctaat tttttgtatt tttagtagag atggggtttc accgtgttag
18421 ctaggatgat ctcgagctac tgaactcgtg atccgcccgt cttggcctcc caaagtgctg
18481 ggattacagg cctgagccac ctagcccggc cgctgccatc tttcttgaaa tgccaaaagt
18541 ttttgtggga aatggcacat ccagatagga atgagcctcc tatgagcgct tttcacgagg
18601 aatctgctta aggcagggag taagcatgga gtatgttcca gacctcactg gagaacctgt
18661 gctaagaaat atgaataaca caggcctgct ggtgactgtg gtcagctgga aaRcacatgc
18721 ccctcaaagg tagctgtcta ttcaggtcaa gcccatcttc tcacttttca agggaatatg
18781 gaaatcggaa tttgtgtgtg caacttttta taatttgtaa agctttgtgg ggcctgaata
18841 aaacacatct gtRgaacaaa tttagcctga gggcccaatt tcgtgacttt cccacactgg
18901 cttgcatgac cttaacaaat tacttgatct ctctgagcct tggttttttt ctgtaaaatg
18961 gaagtaatgc tggcctgata ggcttgaggt gcaaattaac tgagatcagg tgtgaagtag
19021 gtactccatt ctctcgctct tgttttgatt ccgcgatatt tgccagcccc tttctgtgtc
19081 ccagcatggc ccctgtccca ctctgattgc tgctagattc ctcatttcta aacaccagac
19141 agactaaatg cacaaaattg agtggttcac aagtggaagt ggtcgttagc tctgcctggc
19201 tcctttccaσ agatttagtt gctaataaac cgctcagggc acgtggaggt ctgctgtcct
19261 attttagcct aggctgtgaa ttattaacta gtagcctagg ctgtgaatta ttaactagac
19321 ttgaagatca tacatcacat aaatgaatct ggatgtcgaa gctagactta aactatttaa
19381 atctgggagc tgtgaaatga ggaaaagtaa tctttaatag aaattgacga agatattatc
19441 tgccatgaaa gaaaatgaac atgaattctc caagactttt attactaaca tccagatagg
19501 atacgtgttt aggaaactgt atatttttac tttttgcttt gaaataattt taaatttaaa
19561 taaattttgc aggaatagta tcaagaactt ccttctaccc tttatctaga ttcctcgttt
19621 ttaagaatat atttttacat ttatcttata attttctctt tcacaatata tatgatataa
19681 attacaaaca atatttttct cctaaaccat tttttaaacc atttcagttg aaaaaactga
19741 atactgcctt agcccttaat catcataccc tcttagccct taatatttca atgtatattt
19801 cctatcaaca gtgtatgttt cctatttcct ttcaatgtat atttatttat ttcttacata
19861 atcatagtat agttatcaaa ttcaggaaac ttaaacatca tataatacct taatctataa
19921 tctatattct aatcttatca atgatctcat tgaagacctt ttataatgtt tttctttctt
19981 ttccagtaca gttaccaatc tgggatcatg cattgcattt ggttgccatg aatatttaat
20041 ttcttttaat ctggaacagt tcctcagtct ttgtttttca tgatactgac atttttaaga
20101 actgtaagca attattttgt attacctcct tcattggggt ttgtcaggta tttcttcatg
20161 agtaggttca gccattttgg ctggaatgct aggtgaggct ttgtgtcctc ttcagaatat
20221 tactcagagg cacatggcgt ccacttgccc ctagttggtg atgtccattt tgatcactca
20281 gttaaggtgt tgtccagttc ctccactgta tgaataccat ttgtcctttt gtgatgaatc
20341 atttgtggat gcttagtgct ttgttagagg cagagggttt gcacagtgct gtgaaaatga
20401 tttgaaaaca tttgaaaatg agtggaatta tttgattttg tgatttgttt taaagagttt
20461 atgaggtctc aatctgtctt acaggggtag agacagctgt catagaatac atgtaaacct
20521 aactgttttt gaaaaacatt ggtgtgacac ttccataggt ggtttaccaa atttatcaga
20581 tgagtacaag caaatattac atcttggaaa agatgatagt ctcacatgtc atctgcactt
20641 cccgaagagt tgtgttttgg gtccaataaa gtggtataag gtaaaaaaga attttcttat
20701 tgatattttt cctccttttc tttaaaaccc actgtttttt ataggttaag ttgtattttt
20761 taaggcagaa ttggtaaaga aaRttgtgtg cctaagatag attagttagc tagcagtcat
20821 tgataacgtt accttcctaa ttactgtttt taaacatttt tggttattat agctttgtaa
20881 tattttatta tttggatcca ccaccttcct ccagttattc ttatttttca ggcttttctt
20941 tatttttcta acattaatta tatttgttta aatgcatact atgtgcacat ggttcaataa
21001 tcacaaattc taagaggtca ccccctggaa aacctctttc ctgctaccgt tccatatttg
21061 ttctgggctc atcacacctt cctcaactgt ggctaccatg attagtgccc tgtgattatt
21121 cttgtatgat gctatactag caaataaaaa tatatagtct agctctttct agcccttcct
21181 tttttacgct catctttctg cactttgtgt tttcatcttc aaaagttctc ttttcttgat
21241 gatcctggca tatgttgaca tagaaggtaa ctcttggcat ggaggagcac aggctagtca
21301 tttgagattg gaattagttt ttcctgcttg ttaaYgcctg ccagcacacc cctctgggtc
21361 atgagttttc tttatgggaa gattttcatc tattgattca atttctttaa tggtgaaaga
21421 attacgcaaa tttcttactt tctcttgtgt gagtttggta agattttgtg tcttaggaag
21481 tttctcattt cattaaaggt ctcatatatt ctggaaaatt gtttagcagc tcttctcttt
21541 taatgtctgc agacatcaaa accttcaaag taaggttcac cttcagtcat tattcattct
21601 ctcttacaca catacacaca cacgtgcaca cacacacaca cttacttgat tagtttcatc
21661 agagacttgt cagttctagt actcttttca aaagctaact tttgactttg ttgatccttt
21721 ctgttatatg tttcatgttc atttaggttg tttagtttcc ctcttttaca agaaatgtgg
21781 aagtgagtgt ccttatacct gtattttaag gcacgtttgc cagtgaatgc attcctttaa
21841 gattactagc cctagaattg ctcatttgta gggcatgcag atgaacaaag tattcaactt
21901 tgttgatgtt acacaaattg cttcacagaa ttttgtatca gtttatactt ttgccaggag
21961 tattttattt tactttattt tatgacagag tctcactctg ttgtccaggc tggagtgcag
22021 tggtgtgatc atggctcact gcagcctaat tcctgggctc aagtggaagc ccaggtaatt
22081 ttttaaattt tttgtgtgac agaatcttgc tatgatgccc agactggtct cgaactcctg 22141 gcctcaagtg gtcctcaggc cttggcctcc caaagtggtR ggattacagg catgaaccac
22201 catgcatggc tcaccaggag tattctagat ttcctacaac cttgtgttga actttgtatt
22261 ataagccKtt gatttttaaa atcaRtttgg tgggtataaa atgtaccttt ttattttatt
22321 ttgcttttcc ttaattatta gtgagattga ccacattttt cagtttattg gccatttctg
22381 gatcctcttc tgaactgccc actcatatct tttggtatat ttcttatttt acttttcatg
22441 ccattttctt gtgacttata ggagatttta tatatttata tatcctgggt atgattgttt
22501 gcaatgcatt aaaaaaaccc cttttcattg aagtataacg tatacatata aaatgcagaa
22561 atcataattg gacaagcttg ttggattatc agaaagtgaa catacctttt aattaccctt
22621 tcccatgaaa gttaagaaag aaaacattac tagcacctcc gaaggcccac ctcttccatc
22681 ttgcaaaaac tatgcctccc tagtccccca aataaccact tccctgattt atgctatcat
22741 agattggatt taccagtttt tgaattttat ttaatttgaa taaaatcata tgtagtgttt
22801 atgtctagct tccttggctc aatagcaaaa cagtgggaat catctatgct gtttcatgtg
22861 gctatatttc atccattttc tttgctgtgt actatttcat tattattatt gttagactct
22921 tgagtcattt ccaacttctg ggtcttagaa tcaaagctgg tatgaacact ttcctcactt
22981 atgaatgcaa ttttgtggga catattacat gagagtgaaa tagttgggtc ataagggtac
23041 gtagaaaatg ccaaaccatt ttccaaagtg gtgccaatta acagttccag cagcagtgta
23101 taagagttat ttatgcccct atacctgaca acacatggta ctattagtct ttttaatttt
23161 tgctatttgg ataaatgagt aattgtgtct catttcagct ttaattaaca cttccctgat
23221 tactgataat gttgatcttc tttaaatttt cttattggca cttggatgtc tgtgtgtgtg
23281 tgtgtaattt ttttctttga gtgcttgctt gtgaaaattt tttttgagac tagctcttgc
23341 tctgttgccc cggctggagt gtggtagtgc aatcatagtt cactgtaacc ttgaacccct
23401 gggctcgagt gacccttctg cctcagcctc ctgagtggct gcgggttacc ttgtccagga
23461 ggtatcattt ttttttttct gtgaaaagcc aaataataaa tattttaggc attgtaggcc
23521 ggatggtctc tgtttcaccc actcaactct gttttggaag cacaaaaaca gttgtagaca
23581 atgtagaaat gaaggagtgt ggttgtgttg caataacatt ttatttacaa aaacaggtgg
23641 ttagccacat ttggcccgtt gtgtggtttg ctagcctctt gtctatttct cattgatttg
23701 tagtagttct ttatagatct ggatatcagt aattgttaca atgtgtcctt ctaagcaatg
23761 gctaaccttt ctactctggt aatgaggtct cagacttcct agttttaatg cagtctgatg
23821 tattgatttt cctttgtgat tagtactttc tgtgacttgt ttaagaatct ttttcctacc
23881 cctaagtaaa aagacctttt ttcctatatt ttcttcttga agtttcattg tttttctttt
23941 tccactgatt tttaagtgtg tagtgttggt agggtcaaat gtaatttttt tctctgtgga
24001 cttatagttt acctgttctt ttcacgttgc tttgcatgca acgtaaatca tattggtctt
24061 tgtgtgtaga tctgtttcag aaccctctgt agcattccct tattctattt ctttctttct
24121 ctttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
24181 ctttctttct CtCtCtCtCt ctctctcttt ctttctttct ttctttcttt ctttctttct
24241 ttcttctttc ttccttcctt ccttctttct ttcttttttt ttttcttttt tcagatggag
24301 tctcagtctc tctcctaggc tagagggcag tggtgcggtc ttgactcatt gcaacctctg
24361 cctcctgggt tcaagccatt ctcctgcctc agcctccaga gtagttggga ttacaggtgc
24421 acaccactat gactggctaa tttttggtat ttttactaga gacaggattt caccgtgttg
24481 gccaggctgt ctcaaactac tgacctcaga tgatccactt gtctcagtct cccaaagtgc
24541 tgggattaca ggtgtgagcc agcgcatcgg gcccttatgc ttgttaatta ttatggcatt
24601 agataagtct taagttttgt ataagtcctc tgcttttcct ttttctgaaa tgttgccttg
24661 gctattctaa cttctgtttc tgcagcactt ggagatggac tcagggctat gactagcaat
24721 cctaagtgag catcggattt gatcctctgg atcttttaaa aattctgatg ttcagcctca
24781 ccttctgcta actgaagcag gtcacccatg ggtggcgctt agatgccttt attttaaaaa
24841 caacccctgg gcttgcaaat gtaggcaaaa gctgagggtc agcagtgtaa gcaggagggg
24901 tcacctgata ctataccacc tgctcagatt tggtgatcca ggtatggctg tttttgccac
24961 taccatgtgc tcagacctgg aatcactctt tgggcctcag tgttgtcatc tgtaaaacca
25021 gagggttgga atcaattctg caatatctgg agtctgtgat cttcttggtg ctgtgccaag
25081 ggatgtcata tgtcttcaaa gaagttacaa tttatcagag gaagcagaca agtaaactaa
25141 gaattttatt acagcatgag gtgaacataa agaaagcaaa actagagcag accctgggaa
25201 tgtccatggc tatgcttcct ggaaaaggtg actttgaact gtgcttgaag agtgaacaca
25261 gttagcctgg tgggtacggc aaggaaggtc agtaattaga gggaagcagc aggtgcaaag
25321 gcgttgggtg agaaagagaa tggtgtttgg gggccttggt tagagtttag ggcacatRta
25381 gaaagatggt gctagaaaat aaacaccatt tatgccaacc taaagcattt caacagtgaa
25441 tcctaccatc aggagaatgg catgagcaaa ttcacatttg agaaaagtcc ttctgtgggg
25501 ctatagtgaa tacattggaa ggccttgaga atggtggcat gctgatcatt tggactatcc
25561 tagaaatcaa gttaagaagt gcggttcatt tcagaaagtt ataaagtaga actgaaaaat
25621 tagggaaaag gaggaactca tgtctgaggg cccctaattt ttctaattgt aaggagatgt
25681 tatggggaaa atttgaaaga gtaatgtaag taaatagatg gagatgtaat gaatttgtag
25741 tggtaccaag acccctgttt atgtgattat ctcctatagt gctctgctct ctggttgaag
25801 gcttgcagga gagggatgaa gggatccatc agaatgggtc tttgcaggtg aagatgctgg
25861 aaggacggag ggctgcagag ttgaggtact ggaagggaag tgattSaagt gatggacacg
25921 tgaatccagg atggacagga aaggaaatga tacctgaaag agcttggaaa ttagacaaaa
25981 gtagagaggt caggtgggct aattccagtt aagaYagaaa agtgagttga atggatagaa 26041 agttcaggtg gaaaagtgta atgcccatgg tgagtctttt tatcctgtag aggccataaa
26101 actaaaaaga cacaggaaca aaatgaccat accaccttac attttgctga gtcacctact
26161 gctaaggctc tggatggaat tccatgtctc cagctggctt tgctgaaagg taaaggtgag
26221 gatggaggat cttcctgctc tttctgctgg aaagcagagc cctggagaca cggaaatttc
26281 tccagcagca ttgaagtgtc cagtctccag ttctgtggga gctgagtatt ccactttatt
26341 tgttggggtg gctcttcctg atgtggcatt acttgacaca ctggagttgc ataagcggca
26401 actcctggtc tctgaattgc aggtggtgta tttcagagtt gattccccac tttccagatt
26461 gtggtagagg tagcRgctct cagggcaagc tacttctgca gtgtggttct ggcctcgatg
26521 ccacttcctg agtactttca cagatttagc aaagcaccta gtatcttgtc ttgaatcctt
26581 ttctgcataa aatatagaat gatttttgtt tgctaaatcc agacagagat atatggcttc
26641 atggctctgt ttcaaagatt aaatgatcta atctatccac gaagcattta gttcagcatg
26701 agtacataat aggtacgtaa taaataaata ttagagatta ttatgttaca ataaaggaat
26761 gaatgagctg gaatagggaa tcagtcagaa agtaataWat ttaattttaa gaattttgag
26821 acagaggttc tggataatgg caaatcccta cgaaaatcct ggcttacgtc tgggagaatt
26881 gaaaactgaa agtccccagg aagtctttga aattgaagag cttacagagg acaaggtttg
26941 ggtattaaga catctgtcta cacctggaaa agtggtaatg tccccaattt tgtttttgtt
27001 tcaatcccaa attactcctc agcacagtgg ttttgggtcc cYatcactgt gctcaatctg
27061 aacttgctga agttacttcg cgctcttcag ttgctaaatt gacattcatt ttcaacctga
27121 ttgtggcatt caacattgct gggcactccc atcagctagg aactcctttc ccatttcctt
27181 ctaagactta ttctttgtct ctgtttatct tttttatttt tatttttttc tggtgcttcc
27241 tttgtaatca tcactgagtt cttttcctct atatttgggt cttaggattt gaggttcccc
27301 atggtttcag ctgcggtcat cttctgtgct cgcttttgct tacattcaag tggatgattt
27361 atagaaccat ccgtttggct ctatattctc catatggctc ccagttctct tccacttgga
27421 cctttcttcc aatctccaga tttctttgtc caaccgtcta atgtacagtc tccttagacc
27481 ctcccatccc caccactcac cccatgcacc atggttagat ctatttttta atcttaccct
27541 aaataggatc attttcttca tttctttgca ttccttcttc ttcttagtaa cacctttgct
27601 tacctaagac tgtagaagtc ctgctccctc tgcatattcc aaatttgtYa ctaaattctg
27661 tggactggaa ctgcttaaaa taattgtttt ttgtttttta cttgctatcc ctacttccct
27721 gccttagttt aggttccatt tggtctcagt ttatggaaat aaaatctaaa tggtctttag
27781 cattgcacta ttttaatcct ttaaactaca cagcaactaa aggatcWttc tcaaaagaaa
27841 atctgattgt cttattctct tgctcagaaa gcYtctgatg ctcgtctcct cttcatggtt
27901 ttctgtgaca ggtctcctga ctgcctcacc agttttatct ccatcactat tctgtaccca
27961 ctgcatctta gtaagaattc tcaaggctat tttgtgtttc tgaaatattg tacatgctgg
28021 gtcaggagtt ttcttcacgt tgcctggaat acataaggca ttcaaaagtg gacgctattg
28081 ttcttaacat tttaatttta aatcttgtta gtgagacatt aYcctaaaga ttttaaattt
28141 aaatccaagc tcattgagag tttaaacttt gaaataatgt tccagtggat cagaatagag
28201 gYagtctaag ttatagcaaa gcgacagaat gKccctcagM tgcaaggctg aactttaaga
28261 tgattaaaat atgtatatct tgaaagaaag aatgaaccca tcagaaagag gactgctcag
28321 ccatggaagc acagcaaggg aggcccagag actgtgccta gccagagact atccagggca
28381 gcctgtccag ggaagaggtt tatgaaatgt gaggactaga cattgtactt tgtttgggct
28441 gagttcagtg gcttatgcct gtaatcctag cactttggga ggctaaggtg ggcagactcc
28501 ttgagctcag gtgttcgaga ccagcctggg cttcatggtg aaaccccacc tgtactaaaa
28561 aaacaaaaaa ttggggtgtg gtggcacgta cctgtagtcc cagctactcg ggaggctgga
28621 gtgggaggat cccccgagct caggaagtgg gcgacagagc taagaccctg ttccagcaaa
28681 aaaaaaaaaa aaaaaaaaag tgcttgtctg tatcctaaag aaggagacat cacaatatca
28741 gagtctgatc cctttataca tctaactctg attagtaatt cccattttgt ttgacaagca
28801 gttgtcagat tatgagttgg tttcccatat caggtattta tagggaaata atgtaagcct
28861 tataggaagt agcatttcac attataaata aaccaatgct tgtttggcat taattattta
28921 ctgcatcctg ctgggcggct ctattcatgc tgttccaggg gtggagaatg aagtgtgact
28981 ctgaaccatg cctaagtgag gagagagcct aacacttggg caggtaaata tttatttaat
29041 taggagtttg catgttgatt ttatctttta gattgtgcac ttcctgagga gagggattgc
29101 atcttagtcc tgcatggcca ggcctgtcac agtgcaggca aactgcagga attcaaatgt
29161 ttgaatgaac aaatggactc aattagctaa gcagtcactc tgtggactgc agcttcttgg
29221 aggacaggga gcaggtttgg gagaattcag aaggtggccc aagggatgga agaactggtg
29281 attagcatga gaatgtgagc ctaggacagg acagagaaac agtgaggctt gccctctggg
29341 tggttgctgg gagagaaagc attcctgaga ctcactggtc ttctggttgg ttgggtgtga
29401 ggttgttgcc ttgtccatgg aggaggcatg ggaagcggga gaagtgatgt gacatctgcc
29461 caccataaac ctggccagct tcctttgatc actgttcaga ccttcaaatt ggatgttggt
29521 gaagaattat tttggacttc tataa gtcc aatgcttgat aagtgcagaa agtgtaattg
29581 ggcccgcaag gcagtgggag cagttgttat tcacctgggt ttccagtctt ggcagagggt
29641 cttgggccat taagcgggag tccactggca gacatgggcc cctgaaggtg gaggacattc
29701 ctgcctgttc atgtcctcct gcaaaaaact gacccaggct cagttttYct ccatgaagtc
29761 ttccttccaa ctcacgtagg ccactctcct ctcaagtcct actagactta ttgtttgtat
29821 cattcacttc agcctgtaaa atatcctttg tcaaatctgt gtatatctat atacacacac
29881 atgcacatat atatgtacac acacacacat atatacacat tatatacaga ctaggcaggg 29941 aattctgctg cctatctatc catctatcat caatctatca tctacctatt tttctattta
30001 cctagctagc tagctatctg ttgtcttcca gttagactgt aaattaccta aatWctaggg
30061 atcacacagg tttctaagta ttcattgaat tgaattttgt ttttatttgt attaggactg
30121 taacgagatt aaaggggagc ggttcactgt tttggaaacc aggcttttgg tgagcaatgt
30181 ctcggcagag gacagaggga actacgcgtg tcaagccata ctgacacact cagggaagca
30241 gtacgaggtt ttaaatggca tcactgtgag cattagtaag tatgctcatg tatgcctgtc
30301 gccttgtatt ctcttggctt tgtgtgaact ggcttctggc tttgggtttt gggctttgag
30361 caggagtgat tctaggtctt ggtttccctg aaggctagta ggctctcaga cctgccactg
30421 ttagaatcag aaggtgggaa gagtgaggca gaagggcatg agcagcttag tttcctcttc
30481 tgaacaacag aacactcaaa actcttggtt gatttgtgaa aattaaatga gatcatgcac
30541 atagactagc tgctggggta cctgatgaaa cacaagtatc tagacaatag tagatgtgat
30601 gaacatgact gtcattcacc tcagccttca ttgtcgtgaa tattcMtgcg ggccttccag
30661 ctgaggcctc ccctgcctca agtgccgcag agctcagagt tctggatatg gtcctgggat
30721 atcctgctgc tcatggacct gtgttctcag cccagagcag ccagctctct tgaacatatg
30781 cctggaggtt tgaaagtaga atcttagggg aagaagaaac cctaaaagta aattagctca
30841 agccactaat ttaatttaat ttttttaatt ttcaattttt gtgggtacat aataggtata
30901 tatatttata tatagtatgt gcatatatta cataataata ggtgtattat atatataata
30961 atgggtatat gatatattaa acacataata agtgtatata ttacataata tgtgtatatt
31021 tataatccat gagcatagaa tattttttca ttttttggtg tcctcttcaa tttctttcat
31081 cagtgtttta tagttttcat tatagagatc tttcacttct ttggttaatt cctaggtatt
31141 taatttcgKt taattcctat gtattttaat atttttgaaa tgatgatatg gttttatgtg
31201 tggctattgt aaatgggatt acttgtaaaa tatcttttca cattgttcac tgctggcata
31261 tagaaatgct actgattttt gtatgctgat tttgtatcca gcaacttcac tgaatttatt
31321 agttctaata gttttcttgt ggagtcttta ggttttccca aatataagat catatcattt
31381 gccaacaatg ataatttgaa ttcttctttt ctaatttgga tgccgtttat atctttctct
31441 tgtctgattt ctctagctag gacttccagt acaatgttga ataacagtgt tgacagtggg
31501 catcctcctc gtgttccaga acttagag a aaggctttcg gtttttcccc attcagtatg
31561 atactagctg tgggtctgtc acatatggct tttattacat tgagacatgt tctttctact
31621 tccagttttt tgagggtttt tatcatgacc tgctgaattt tatcaaatgc tttttccgca
31681 tcaattgcaa tgaccatatg gtttttagcc tttattctgt tgatatgatg tattacattg
31741 attgatttgc aaatgttaaa ccatccttgc atcctaggga tgaatcccat ttggtcatga
31801 tgaatgatct ttctaatgta ttgttgaatt ctgtttgcta gtactttgtt gaggattttt
31861 gcatcaatat tcatcagaga tacttgccta tagttttctc tctctttttt ttttttgatg
31921 tgtctttgtc tggttttggt atcagggtaa taactggcct cataaaatga atttggtagt
31981 atcttctcat cctctatttt tttgaatagt ttgagcagga ttggtattag ttcttcttta
32041 aatgtttgtt agaattcagt ggtgaagcca tccagtccta gacttttctt taataaagag
32101 acttctttct ctttaataaa gatactttat taaaatttct atattgttac ttgttattgg
32161 tctgtttagg ttttggattt cttcctggtt caatcttggt aggttgtatt tgtctaggaa
32221 tttgcccatt tcttctagag ggatttccta ttcattggca tacagttgct catagtagcc
32281 attaataatc ttttggattt ctgcaatatc agttgtaatg tctccttatt catttctggt
32341 tttatttatt tgtatctcct ctcttttttg cttagtctgg ctaaaggttt gtcaattttg
32401 tttccctttt taaagaacca actttttgtt tcattgatct tctgtgtttt tttcatttca
32461 atttcattta tttcttctac taattttggg cctggtttgc tcttgctttt ctagttcttt
32521 aagatacatc attagattgt ttgtttgaag tttttcctct tttttgatgt aggcacttat
32581 agctataaac ttttctctga gtactgct tgctgtatcc catatgtttt agtatgttgt
32641 gtttccatta tttgtttcaa gaaatttttc agtttccttc ttaatttctt cattgaccca
32701 ctggtcattc agaagcatac tgtttaattt ccatgtattt gtatagtttc caaaattcct
32761 ctcgttattg atttctagtt ttattccatt gtggtcagag aagatgcttg atattattcc
32821 aattttttca gtgtcttaag acttgttttg tgacctaaca gatggtctgt ccttgagaat
32881 gatccatgtg ctaaggaaaa gaatatgtat tctacagcca ttggatgaaa cgttctgtaa
32941 atggatctat tagatccatt tggtctatag tgcagataaa gtcagatgtt tctttgttga
33001 ttttctgcct ggaagatctg tccaatgctg aaagtgggat attgaagtct ccagctatta
33061 ttgtattgga gcctatcttt ctctttagct ccaataatat ttgtttttat atctgagtgc
33121 ttcagtgttg ggtgttatat cctcttgctg aattgacctt tttatcatta catagtgact
33181 tgctttgtct ttttttatag tttttgtctt gaaatctatt ttctctaagc atagctactc
33241 ctgctctttt ttttgttttt gattgtcatg gaatatcttt tttcatacct ttattttcag
33301 tctatgtgtg tctttatagg tgaagtgtgg aaacaatcaa tgggtcttgt tttttcattc
33361 attcagccat tctacatctc tttattggag agtttagtcc atttacattt aatgttatta
33421 ttgataggta gaacttactc ctgtcatttt gttatttgtt ttctgcttgt tttggtcttc
33481 tcttcctcct ttctttcctt cctgtcttct tttagtgaag gtgattttgt ctggtgatat
33541 gacttgattt cttgcttttt atttttttgt gactctattg cattttttct ggtttgaggt
33601 ttccatgagg cttgaaaata ctattttata acccattatt ttaaccggat aacaacttaa
33661 tattgtttgc ataaacaaac aagcaaaaag aaaactaata aaaattttac accttaactt
33721 tattcccctg ctttttaact ttttgttgct tctatttata tcttgtactc actacacctt
33781 gaaaagttgt tgtagttatt atttttgatt ggttcatcat tcagtctttc taggataaga 33841 acagtttcac accacagtta cagtgttaaa atattctgtg tttttctgtg tacttattat
33901 aaccagtgag ttttgtgcct ttgggtgatt actcattgct cattaatgtc cttttctttc
33961 tgattgaagt actcccttta acatttcttg taggacaggt cagtagatga aatccttcag
34021 ctttcgtttg tctgggaaag tctatttctt cttcatgttt gaaggttatt tttgtggata
34081 tgctattcta gggtaaacgt ttttaaaatg tgtcatgcca ctcctggcct ataaggtttc
34141 cactgaaaag tctgctgcta gatgtattag agctccattg tatgttattt gttccttttc
34201 tcttgctgct tttagaatcc tttctttatc cttgaccttt gggagtatga ttattaaatg
34261 tcttgacgta gtctcctttg gattaaatct gctgggtgtt ctataacctt cttgtatttg
34321 gggactgata tctttctcta ggtttgggaa gttctctgtt atccttttga ataaactttc
34381 tactcttttc tgtttctcta cctcctctgt aaagccaata acttttagat ttgccctttt
34441 gaggctatct tctagattct gtatgcaatg cttcattgtt ttttattctt ttttcttttg
34501 tctcctttga ctgtgtattt tcagatagcc tgtcttccag cctgctaatt ctttcttctg
34561 cttgatacat tcctctatta aaggactctg atgcattctt caatatgcca attgcatttt
34621 ttcatttcca gaatttctgc ttgatttaaa aaatcttatt tcaatctcct tgttaaattt
34681 atctgataga attctgaatt ccttttctat gttatcttga atttctttgc gtttcctcaa
34741 cacagctatt ttgaattctc tgactgaaac atcacatatc tctgttcctt caggattggc
34801 ccctggtgcc ttatttaatt catttgagga ggtcatgttt tcctggatgg tgttgatgct
34861 agtagatgtt cttcagtgtc tgggcattta aaagttaggt atttattgta gtcttcactc
34921 tctggactta tttgtacttg tccttcttgg gaaggccttc caaaggattt gagtgtttcg
34981 atcaaagctg tatctgcttt agggggcacc ctaagcccag taatgctgtg gttcttgcag
35041 acctgtagag gtaccacctt gatgatcttg gacaatatct gggagaattc tctagatatc
35101 aggcagagac ttgttctctt cccttacttt ctcccaaaca aacagagtct gtctgtctgt
35161 tctgagccac ctaaagctga tggtggagtg acacaggcac cactttggcc atgaccacta
35221 ggactgctgg gtcagacctg aagccagcac agcgctgggt cttgcccaag gcctgcttta
35281 cccactccct ggctactgct tatgtttgct ttaggccctg gtgctctaca atcagccggt
35341 ggcaaagcca gccaggcctg tgtccctccc atcatggctg attgccactg gcaaggtctc
35401 tcaggccctg ggtggatcca gaggtgccat ctaggagtga gggattagag taaacaaacc
35461 ttagaagtct accaagtgtt tttttgtact gcagctgagc tggcagtcaa accacaagac
35521 gtagtccttc ccactcttcc ctcccctttc caaaggcaga ggagcctcag catccatagc
35581 cagtgccaca gccggccaca aggagtactg ccagactacc gcagattttc ccttaaggtc
35641 caagagctct taagtcagct tgtggcaaat gctgccttcc tgggactcac tcttcagggc
35701 actgggctcc cttctggccc agggcatgtg cagaagtgcc atccaagatt caagtcccag
35761 aatcagggac ctcaagagcc tgcttcatga cctaccctcc cctgtggcta tgctagtacc
35821 tgaagtgcaa gacaaacttt tccttctgct tttctcaagc aaaaggagtt ttgccctata
35881 atcactgcag ctaataatgt gctcagtctc acctaaagcc agcaagtttc agatgctcac
35941 ccaaggcatt caatgtaata cctggataat tgctactgat tattcatggc acaaggactc
36001 ttaagttagc aggtgatgaa tgctgcaagg actgaatcct ttccgtcaag gcagcgggtc
36061 cccttctggc ccatggtatg tctgtaaatg ttatctggga ggcctggaac aggggcttca
36121 tgactctgat cattgttctc tcttgctgtg gctgagctgg catccaagat gcaagtgaag
36181 tcctctccgc tcttccctct cctctcctta agcagaagga aagcgtctct tttatagctg
36241 caaggtgtgc agtctggggt gataaagagg ggtgatgccc acactccctt ggctgcccta
36301 gatgggaata ctgaggtata ttgcatgtcc cactccagtc caccgtctct gggcagcact
36361 aggactcacc taagagttgc agtccctgtg gcccagactg cctctcaagt ttacttagag
36421 acccagagca ctttagcttg tggtggtaag atttacagga actcaagttc tgatcactgg
36481 gattaacaat tccctctgtc tagggctggt ttaaatgttc cctccatgag cccgtggcag
36541 ctgagtttgg tccagttttc ctttctgttc taacaagtca gcattgagtt cagtgcctca
36601 caattgtggt gtcctttctc ctccagcaac cagagacact ctcagtacca tgccgccact
36661 gtcaggggtt ggcgagagtg gcattggtga ttgaggactg ctttttctat ctcattggtg
36721 tccttttctg tgatacagat ttaaaaccag atactatgag tgatttttgg ttcttatgaa
36781 ggtgtttctt ctgtgtagat ggttgttaac ttggtgtcct tgtaggggag acaattggcg
36841 gattcttcta ttctgccatc ttgttccaca ttctctcccc aagctataca ttttacagag
36901 ttccaggagg gKagcaactt attcaaggtc acaaaSctgg ttattgtcag aaacagagcc
36961 agagctctgg cattcaatgc ccaggccagc attggttttt ccaaacacac tggacaagga
37021 gttcctgctg tggtggcttt tgctctttct ttagtagaaa gttgttttct atatttactc
37081 atctagatga gaagaactaa aggctggata cttctttgat gtagaccttc ctatttgtca
37141 ctagtttcca tcacacttca gagtactagg ggagactgag ctaYttctgg gtggtgtgga
37201 tccctatggg gatctggtca gcatgggtgg ctccctgctg cctatgcagg acagggccct
37261 ttactctgta cagtccagtg actccctgaa ttccagctgt tcttctagag agcccgttct
37321 agtcctccta tgttctttgc agcaactgct catttgattt aaatattttg gggtggtttt
37381 caattttaat tgttcatgct aaaagcacag tcattaagaa aattaattgt acaaggtttt
37441 tttgattttc ctgctcttgg gttttctgct gaccattatc tctctgaaag aaagcacctg
37501 cctcatcttg ttcacagttg aatccctggc cctgagccca gtgcctggcc tagactaggc
37561 acagatctat ttattaagtg aatgattgac tactataatg cattaatgtt acattggtaa
37621 ctgaggggaa attttgtaag gtgaaattgc tcaggtaaaa tgaagaatcc cttaagaagt
37681 aactgggttc agtagtcact acttcatgtt caataaacat ttatttatga tctgttatat 37741 gccagtatta tggaaggtcc tgataattca aaagtgaaaa gcattgtttc ttctactatg
37801 aaactgtcag acatggtgat ggtgaatcta ggggttaaat ggatcatttt aacattatgt
37861 gctaagggta gagccacaga cagtgtttgc ggagcaggaa aagaataaga agggtccgtg
37921 ggtggcacgc aaatggtctg ggaaggcttc caagaggaaa ggagttctca gctgaatttt
37981 gaagaatgaa taggattcac aaaagtaaag gagggtgagg aggggtctct aggcagagag
38041 aacagaggga acagtatagg acaaagcatg gaagtgttaa gcattatgtt tatgttggat
38101 ctaaaatgac tttcattaga tcctatgtga gtatggggtg gggagggtgg gagctgaggt
38161 catggagtta agcagggcaa ggtccagggg actgtttatg cataggcttt accatgcagc
38221 cactgaaggg ccctgggacg gtgcaaatgc agagtcattg ggctgcattt gtgatgggag
38281 acatcagtat tgagatgatt tgaagccaga gttgaagagg gcctggcagc ttggagacca
38341 cttaggaggc tgataaaata tccaaaagag tgctgatagt ctcaacttgg gaagaggcca
38401 tgggggagct ctccttcaag caatcattta agaactcttt gctgagtact gaacaaagct
38461 aggttctgtg ccaggcagag agaacatggt ggtgaagaaa acagccaccc ccactgctct
38521 gatgaagctt gaaggctgaa aggaaggcag agaataatca gataattcac taataagatg
38581 tgtaattata gggaagatga aagcgtgaag gaaaggaaaa atctgagctc aaacagacca
38641 gggcctcgtg agaaagcagt ggctcaggga aagctttctg ataatagtga tgctgatggt
38701 caggaagcat tatgtggatg atggagttgg ggagattttt ttccagactg aggaagtagc
38761 aaatgtgaag accctggcac aagagggaac ttggagtatc tgaagagtag aaagcagggc
38821 tagagtgatc ctgaatgaga gaaattatgg caggtgatga ggttgggtaa gtagtcgggg
38881 gccaagatca agtaggaacc agcaattcag agtaagtagt atgaatttta ttctaagaac
38941 aatgacaagc agccagacag atcaaaagca ggagagtagσ atgagttgat tttcatttct
39001 gaaacagcag actggccgct gtgcacagaa tgatccattc cagggtggat cagaagtgca
39061 ggtRcagaag cgcaggtaag gcatgaaggc acaggtaaca tgatgtcatt gaagatggag
39121 agatatggat gggttcaagg caccttaaga ggtaaaaccc acagatttag tgttggactg
39181 aatatgggga gaaatatggc aaggtcaaaa aagttaacca ggctttttga catgcactat
39241 tgactggatg gtgatgctat tcagtgaagg aaaatggctc tggaggaaaa ccagatttag
39301 gagtgagatc atgagtttgg tcattgctac gttgagtatg agKtgccttt ggatggtgga
39361 ggtccagagt aggtcatggc ctgtatgggc atggagctta gaggaaggac tggagacatg
39421 accttcaaag tcattggcct tgaaatgata tttgaagtag tgggtgtgaa tgagattgct
39481 taggaaaata atggaaaata gaaggcttag aagtgaagaa aaagacagac tgagaaatga
39541 ggaggcaaaa gtagttgaat ttggtgattg acaagttgaa gaaggtgaaa gaaaagctgt
39601 tgcctagaat ggcttctgga ttttacatgt gtgtgatcta gtgggtgatg atacattaac
39661 aagctgggga taacttttgt ttgggacatg ctgcatttaa atagtttgtg gaatgcacat
39721 ttattattgc catcataaaa gatatgtatt tttgcatttt tcttagctcc tctcttacaa
39781 cttttccata tcccactcca aatatatagg aggaatactg gaactaagta ggtgatcgct
39841 aaattttggc agacaaatgg gagaggaaag aagtagagaa agactgaggg gcagggagtc
39901 cagggagtca atacagggag ataatgctaa agtttggtgg taggatgaaa gagttagaat
39961 aatagtagaa gaggacggga tataaaataa tatggaaatg cagagttgga ggaggaagag
40021 gaaaactgaa gatatgatga accctcacag atccctcatc caactttgac aattatcaac
40081 ttctggatag acttttttca tctttacctc tacccattcc caccagttcc caagattatt
40141 ttaaagtaat tcaaaaacat gatatgtatt tttccatcta cataacattc ttataaggac
40201 aaaactatag aaataggaaa cagattaatg gttgccatgg aacaggaact gcatgaggga
40261 gttttttgaa ggtaaaacaa gagggttact atttctctca agctagcacc taagccaggc
40321 ctttgtctat agccactgcc tgcaaagtgt ttttggatta ttaagtattg agattttatt
40381 ataaaagctt attagtttat attataaaga atatagttta tggtttatac caaaatatgg
40441 ccaaaatgaa ctctcttgat agctcagctt ctagcttatt ttttttttct tttttggcaa
40501 ttcagttact tctggttgaa aatgtgtatt tatggagtga gattttgacc agagcttatt
40561 gatggtctgc tctgttgggc ttcatgctat tacatcaaag tacttgggaa tgtatcatac
40621 gtgattctaa tgcaatttcc tgtgggtatg atttcttagc agaaagagct ggatatggag
40681 gaagtgtccc taaaatcatt tatccaaaaa atcattcaat tgaagtacag cttggtgagt
40741 aaaattattg aagccattga aatcaccagg ggaagagctc attatgtttg catattctgg
40801 tgaatatttt gaatgttaag gatgaagata aatcctatac acacccagtt tccagctttg
40861 gatatacStg agctcatggg gagaggaatc aaaataaaac accagagagc cgaagcRtgg
40921 aaaagttgtg gtagcagaga agtctggcaa tgaggactat gggcccaaaa tgattattat
40981 aaatctgttt atgcaaaggc aatgaaaatg caaataattc ttcagacaat acataatata
41041 atataaaact actattaaat aatgttgacc aggagttctg gattatatta cctcacaatg
41101 caagatatat taMaggagtg aaaaaaatta tgatgttata ttccttaatc tatatggaaa
41161 aggatcaata agcattgcct caatttgtga tctaagtaga taaaaaggca tcaaattact
41221 ttttaaatta aaaaataatc actagtggcc aggcacggtg gctcacgcct gtaatcccag
41281 cactttagga ggctgaggca ggcagatcat gaggtcagga gatcaagacc atcctggcta
41341 acacggtgaa aacctgtctt tactaaaaaa tacaaaaaat tagccgggca tggtggcagg
41401 cgcctgtagt cccagctact tgggaggccg aggcaggaga atggcgtgaa cccgggaggc
41461 agagcttgca gtgagccgag atcgcgccac tgcactccag cggcgacaga gcgagactcc
41521 gtctcaaaac aaaacaaaac aaaacaaaac aaaaaaaatc actagtaaaa taaatatgtt
41581 gtattacatc tgaaaaaaaa gcaaattaga caaaaatctc aagatctcac aaaatagaaa 41641 gttttatgtg tcttagtgta tcaaactata taatgctaaa agtctcagaa atacaataca
41701 acaaaacaac acaattgttt cagttgtagg gggagatttt aacatactct tgctttgaga
41761 aatttactag gaaagtaaga gtctacatgg ttcgaggaat agtaaaag taatgtgtct
41821 aatacataga tcactctcag aaacatctat gaaaaaccag agtccaaaag aggaaattgt
41881 acagatcatg gggtataata acgatacagt aaatgtaaaa atttatatct aaaccaaaac
41941 aataaaataa tcgcacttaa taagtatgtg aagtgacgga tgttaatt agcttgattt
42001 aattattcta caatataaac atatatcaaa acatcacatc gtacccataa atatatgtaa
42061 ttattatttg tctattaaaa ctaaagaaaa atttaaaaac ttaaacaaca acaaaaaatc
42121 tcttaattat ttgcattttt gattagagag ccaaagccat agttaaagaa tatttagaaa
42181 ataatgatag tgagaatacg tcatatcaaa tttcatggca tatgaccaac tctaaacaag
42241 tttatatctt taaataacat tattattagt aagtgtggaa ataattaaaa tatacaacta
42301 accatttgac tctataaaag gaccaactaa acaacaagaa agaagtaga aaataatgaa
42361 tttattaaag gaaaataaac taatagaatc tgtcccagag t tggttaaga acagaagagt
42421 tgaggtgggg gttggggaga aagttaaact tccagcaaat ctaatcccca aagtgcagag
42481 acacccaaat ataaaaaaat tagaaatatg ggaaagctta t ataaaacaa caaatggtaa
42541 gagataaaat ctgtttaaat gcctctaggc ccatatgttt ttaggataat tcttttaaac
42601 tttcaaggaa ataataatac ctataataaa ggataattgt ctacacatta ctcattatgt
42661 gaatagtctt aaaagacaaa tttggctgtt ttatctctct taattgactt tctttctcta
42721 ctcctgtctt tggaaattct agccaatgta tttagacaat taaaaggcaa gagaaggagt
42781 tttggaagtc ttggagggag gaagataaac ataactttta aaacatgatc tactggtttc
42841 tacttagaaa ttttgagaaa attaagtaaa aaactataat cactagcatt ttcttattaa
42901 tgttatttta atacaaaata aacattcaaa gctaatagca ttttacatg cctgaaatag
42961 catatattat gtaatcaggg aaaacagcat tcacaattgc aatacaagaa ataaaacagt
43021 aaggaacaac tgaacaagaa attaggagga cttgcctaca tgattaaaaa tgcagcattt
43081 tatcatttta tagatggaac ataaaagaat atgtgtttta gtgaaatttc aaaagatgtt
43141 cctaaataga aacactcagt attaaaaatg ttatttctct tagattaata tacaagttta
43201 atataatacc aattaaatta ccaaatatcc taaaacttgt caaaacatgt ctaaaatttc
43261 tgtcaaaaat gctggaaaca gttagccaag aaaaaattga tagaagaaa aaagagccat
43321 ttccttgtaa gtattaaaat atattataaa gatagagatt attagtatgt caacaaaatt
43381 gctgactagg ggctcctagc actaattccc gtacaaaagg gccaaaatat aaaataaata
43441 gctacatttt gactagcgtg tctgaaggag ggcgctggag tgcagcatgg aaatgatgga
43501 atccctgtgg agcacagaaa cccaggatgg cagcatagag aggggaggaa atcacccttt
43561 ctctgtcact ctgtttcccc caccaagatt gacttggagc caagagaaac ttctctttgc
43621 agggaaaagg taagcagaag gcctctgcca ccttcattat taccacagac acctgcagtt
43681 cttgctacag aagaaagctg cagtcctcac aggtcctgag cccagtttgg ggagcagcct
43741 ggagttctca tggctatatt gctccagtgc aggaaactac attgtgcata cccttatccc
43801 ctatgaccca tgctgctaca tcatgccact gtcttggaat tatagctact gctagagtga
43861 gtcctgttct gggggccagt agccactgca tctctccatc cccaatgctt tcccgtcatt
43921 tcaccatgtt catacaggtg gctacaactc caaaatcctg gttacttaga gtatgggccc
43981 tatgaaatta ctgtgatcct ggttcccaaa tgcacatggt gccctgcttc ctgtatggac
44041 aggcagtcct gcacaactgg ggaagctttc cctagccagc agacctactc tgctcaccct
44101 catacccatg agggtgtaca tactcaccct catcctgaga accagcccag tagccctgca
44161 cctggcaaga cgacacccct tttccattgg acctactgtg tgtgcacaca cacccttggc
44221 ctgagaacca acatggtagc ccagcaccct gcaaagccat gccactgcca gtacaaactc
44281 ctgcagccta ggccactgag acactcaaag atactgcaga tgtggattgt agctgaagaa
44341 actgcatgaa gactacactt ctgtctctgt ctagaaccaa agccaacata ccttatccaa
44401 ctgacatgct aggatgcatc tacagaaaaa gtctttctct aataaagcta cttcataaaa
44461 ttagaagagg tgactgttgc accagaagtg cagctatcaa cataaggaca caagaaacat
44521 gaaaaaacag gaaacatgaa aaaacaggaa acatgatacc tcaaaggagc acaataattc
44581 tccagtaaca aacctcaaag aaaataagat ttgctaaatg cctgaaaagg aaggaatcca
44641 aaataatgat cttaaggaaa cccagctaga tacaagagaa tacaagcaaa taatttaatg
44701 aaatcagaaa aacaatttat gatctgaata agaaattcaa σagatagata ttataaaaaa
44761 gaaccaaaga gaagtctgag cttaataatt caatgaatga aataaatgca attgagaatt
44821 caacaacaga attcaacaat ctagtgatca ttatataatg accttctttg tctcttctta
44881 taatttttaa cttgaagtct attttatctg atgtaagtgt agctactcct gcttgctttt
44941 gttttccatt tgcatggaat atcttttttt catctcttca cttttcgtgt atatgtatcc
45001 ttactggacc tactgtgagt cagtgagtaa gtgagtctct tttaggcagc atatagttgg
45061 ttcttgtttt tttcttttaa tccattttgc cactgtatgt ctttgaatta gagaatttaa
45121 tccatttaca ttcaagatta ttattgattg gtaagaacat gactcctgac attttgttat
45181 ttgtattctg gttgttttgc agatcctttg cttctttctt tctctcttgt ttacttttgt
45241 ggtttggtgg ttctctgtag tcctaagctt tgattccttt σtctttttat tgtgtatctg
45301 ctgcagtttc tatcattgtg gctaccatga ggctaaaata aagactttta tggttataat
45361 aggctatttt aatctgatta caatttaact ttggtcacat aaaaataccc ttgactttta
45421 ttgtccccct aacagtttat acttttgttg ccttaattca catcattata cattgcgtgt
45481 tctttaataa ccaattgtgt ctgtagttat ttttgaccat tttgaccttt aaacttatta 45541 ctagagtctt gaaagattta catagcgcca tttcagaatt gagatattct gaatttgatt
45601 ttgaatttat ctctactggt tagttttcac atgtttttat gatggtaatt atcacccttt
45661 cactttcagt tgcagcattt ccttagggat ttcttgtaag gctggtctag cagcaatgaa
45721 ttcccttagt ttttgcttgt ctggaaggga ctttattttt cttacatttc tgaaagatag
45781 ttttgctggg tatagtattc ttggatagca gtttttattt ttgttcagca ctgaatataa
45841 tatcctttgt tcatgaattg gaagaattaa tattgttcaa atgtccatcc tactgaaagc
45901 aacttacaga ttcaatgcaa tccctactaa aataccaatg acattatttt gacagaaaga
45961 gaagaaacag tcctaaaatt tgtataggac cataaaacac cctgaatagc caaagcaatc
46021 ttgagaaaaa gaccaaaagg cccaaaacca aaaacaaagc tggaggtatc acactacctg
46081 acttcaaaat atactaaaaa gctatagtaa tcaaaacagc atgatgttag catgaaaaca
46141 ggcacataga tcaatggagc agaatagaga gtccagaaat aagtccacaa atcaacagcc
46201 aactgatatt tgacaaaagt gccaggaaca cacattaaac aagtaacagt ctcttcaata
46261 aatggtgata ggaaaattgg atatccacat gcagaagaat gaaactagac ccctatcttt
46321 taacatattc aaaactcaac ttgaaatgga ttaaagactt aaatataagc ctgaaactat
46381 gaaactacta gaagaaaaca tagaggaatt gctcatgaca ttggactggg caagatgttt
46441 tggataagat ctcaaaagca cagacaacaa aagttaaaat agacaaatgg aattacatca
46501 aaccaaaaag cttctgaaca gtaaaagaaa caatcaacag agtgaaaaca taatctacag
46561 aatgggagaa aatatttgta aactgtgcat ctgacaaggg gttaatatcc agaatataga
46621 aggaactcaa acagctgaat aacaaacaaa caaacaaaaa acaaaaaaca gaacaacaaa
46681 taatttgatt aaaaaatgga cagaagacat tgcttctggg attcagacaa tatcctgttt
46741 tcttgatgag gtgaaagtgt tacagatatt tgcttatgat aattcattaa cttgatattt
46801 ctattctata ctgtttggta catgtgtgtt atatttcaca atcatttttt aaaaaaatat
46.861 catttagaat aaagaacact ccttgaatgt tagaatttac taagctcatg ggacaaagtc
46921 cactgagact ataaattgat gaaatttgtg aatgtgtgta gaggcaagat aagggaaaga
46981 gagggaaagg gtgggggtta catttggtga agcagaaata tcactggatt tggtgttaga
47041 aatctagagt tcatatttca tttcttcctc taattaattt gggcaagtca ctcaatctat
47101 ctgaacttca gtttttgcat ccttaacatg aggataatag cccctcccct tttcctgcct
47161 tgtaagattg ttttgaagat tcaaagactg aaggataaaa tgcataaaat actttgtgaa
47221 ctgtcaagtt ctttgctagt gttactagga gtagaaatag catttgtgta cctgatgatg
47281 tttggtaatg catgtgtgtc cctttacaat ggttgtcctg gaaggccact tgccccttgt
47341 ggWctctctc cagggaaaga aaaaagtaga ttaacatttg cctagggggc tatttctggt
47401 aatcaaaagg tattcgaggc tcgagagtac gatgcacttg taatccagat gttaacaaat
47461 ttgaaagttt gtagaatttt cattgaatat tgatgatatt ggtttttttt aggtaccact
47521 ctgattgtgg actgcaatgt aacagacacc aaggataata caaatctacg atgctggaga
47581 gtcaataaca ctttggtgga tgattactat gatgaatcca aacgaatcag agaaggggtg
47641 gagtaggtgt tttgcttttt tgacttctct aaacgctagc aaggatttct ccatctaagt
47701 gaatctggta tcactactgc cttctcctct tgtttttgcc tctcaatgat tcatgttatc
47761 aatcccacct atcacatagt tagggagata tggtaaaaga ccaggYatcc ctgagagcag
47821 taagatccat ttctcttagc tactactcaa aattagtccc atttccattc agttatatca
47881 tgagccatcg gccttcaaag cttaatgccc Ygggcataca aagcaaacac tggaaatgac
47941 acaaatgtgt atattgcaac agtagaagaa agaaatagta gtatagttct ttgctatact
48001 aaacaagcRc caatggggac tcttagggaa gacagtgcat aatcattagc taattgaatg
48061 ggtataaact caagttatgg tggtataaat ggagtggtgt aaataaaact aatgaagtca
48121 gagggcagga gagcttgtgt tgggcctcgc agtatggata agttaggata cttggagagg
48181 aataggggaa aggcctttgg ggctgagaat ggtgtctgta gctaacagaa ccatacttcc
48241 ttgtcaccat gcagaagaaa atgcaaattt gggaatatac aatctacaaa cctcactggg
48301 ccagtcagca aagtattttt aggataacat gatggcccaa agtgttctca aagaaaacac
48361 tttatctcca gaaaacagat tataaaatat gttgggtaaa tctgactcat gtattaatga
48421 cttactcttt tcttttatag aacccatgtc tcttttcggg aacataattt gtacacagta
48481 aacatcacct tcttggaagt gaaaatggaa gattatggcc ttcctttcat gtgccacgct
48541 ggagtgtcca cagcatacat tatattacag ctcccaggta atactccagt gggttacaca
48601 ctgttcagag tgttcaaaac Satggccagg aaacacatct gaaggagcag tgactctaaa
48661 tgctcagtgt gaggcatgag ggtgatatta aagggacaaa ctcagtatga aatctaggga
48721 aaatctcatg caacagctca taatgttgtt ggagtgaggc tgtgatttta ttgcagtata
48781 ttttgaaagt gccatatttt caatacatcc agattttata catcaaaaca gaaagaaaac
48841 aaaagctttt ctttattaag cgtgattgcc aaatgttttg cttttgattt tcaactttta
48901 gatttagtat aaataatttg atataaagcc aaaatgccta tgtatatttt taccatggaa
48961 ctttgtaaaa ttatctgtag aggctgaatt ctgatattta agcaggaggg cttccaactc
49021 aatgtgtgta tacgaattgc actctgagta ccgtacagaa ctaattgatt atgcattgga
49081 agtaataaag tcagtgaaaa gatagtggag ggtgaagcca gaatcaggag aacaacttta
49141 aattcgtaac ctatcagggg aggtgtgtga aataccttgc aaaatgctgt gtggtttacc
49201 aagacagttg ttcttgattc tattaatatc attagtgtat gtgtststgt gtgtgtgtgt
49261 gtttgcacac gcacgtgtgt ggctagctac atgcaagaNa gNggacttga atttgctgat
49321 gtcctttaat gatcagttaa acctatgctt gcatacatca agctaaagcc ccaccaaata
49381 tttttctaga acctaacaga aaacacagtg gttgctgtat ggagttagca atcgtgcctt 49441 tgcccctgcc aagctcctgg cctcctaagt gcccgttacc tcccttagaa ttgcagtgaa
49501 tagggatctg tgcRtggcag cttgcagctc tgggtgtgca cattctctgc ttcacttctg
49561 tgtcctgaag gccagtgtcg ttctggcctc agctgcctta actgtgagtg agcacagcac
49621 cctctMctca ccctgagcac atggggaatc cttcttgggt tgcaacatgt ggaaggaccc
49681 ttgggttcat ctgtcaccac tgcccatttt ttctcttctc actggctttt ctttgtcata
49741 aagcatcctt ctccatcact ttcccccagt cagtcttgtg tttgccatct Ytctctctct
49801 ggtacctcta agaggttcat catctgtgct gcttttcttt ctgtgtcctc atccctcaaa
49861 tctctttccc ctttatggca tcaactgtca ttcctgagca ggtgcaaaca ggttccatat
49921 attgagctgt atactgtctt cccccatgac agctctgcgt ttccagctgt gtaagggact
49981 gc-agatacac tggctgatgt cagaaagcaY gtttaaactc tccaacctcc tggttctgtt
50041 ttttcttacc tttgttagtg ggactcctgt atcttccacg ttgttcaggc tcaaaatctg
50101 gggtcatttt atgccttccc ttatcctccc tcatgccaac acccaatgag ttgccaagct
50161 ctgtggattc ctcccctcct gcccattccc actaacgagc tggatggtag ggtgactcct
50221 gcσctacact ttaaggtcag gttttcaggc tcagatccta tcttgtccac ttaggagctg
50281 ggtgaggaca gcaYtgtcac tcaacctctc tgtgcccatg tctcctcatc tgggaaatga
50341 gge-ggatagc gacttccttc cacgactgtt gtaagaatca gctggaattt tcttttatac
50401 ttttttattg tggaatataa tgcatatatg tgttataaca tatgcacata tatggtaaag
50461 gaacacagaa tttctacatc acataacaag tcattgtata gcaaacactc atgaaactac
50521 cacctggatt aagaaaaatg cattgcctga aaaactcctg gatgttcttσ cctgatcctc
50581 ccctcctgat aatcatcccc ccaactttta ggaaagtcgt ttctttgatt ttctatctat
50641 gctgatagtc ctaataatac aatttatttt tgcctgtttt tgagttttat attaagagaa
50701 gtatatagta tgctttattt tcttaggtgt gggggcttat cagtgtatca ctgatatagc
50761 atgtagctta gttcattaat ttacgttgcc gtatcctagt ccattgaata actaggtcac
50821 aatttatcca ctgggctata aatatgtggt ttgcattgtt ttgagtttgg aactcttaac
50881 aaagaatact gctatggaaa ttcctgcttg tgtgtctgtg tacccatgta gaggcatccc
50941 tccaggatat atcatgaaga gtagagttgc caggtaagag tctgtcatta acatttctat
51001 ataatgccat actgttctac aatgtgattc accgatattt actgataggc gatgaaatgg
51061 aaactcccgg cttgacattc agggcctcct gatctacttg ttcccactca tttcccagtt
51121 gtcaccttca tctaccccac agaacagaga gccagatcag agacaaaggt gggtcttttg
51181 tgagctcata ttgtgatgaa gtaggtgagt ttgagacaag tgcagaaatg tgcggtaggt
51241 cagtgaggac aggttgaaaa cctgttttca cccaagcaga gcctgctggc gtttcctccc
51301 ttctgacttt ccattggctt acagcagaaa tgcagcctcg cttaggccag agacagagac
51361 tcagggtcca ccccagagaa aagagaagct gttgtaagaa gccttggaga gtccaggaga
51421 cctgaagtgg ttacaactta aatctgtccc aacctagaag tttgagttct ttactgaata
51481 aDatagactg aagctgacca atagcgattt ccatcccaat actgacttgt tgaacttttt
51541 gaaεagcactg tgttcYgaag gattctgagg ccaagtccaa gctcagagga gctaatgctg
51601 tgaccagtta gttaacacct gtcaagcttg tggagggatg gagtccttta tcccctttgt
51661 ttteaagctca tgcttcttaa atcccttagt tcctggcaat gctcatttta tctcaaatgt
51721 agagtatttt ggttctgttg acttagtttt gtttgtcctg agttcctagg aacttcaccc
51781 ttttaaatcc aaacctcttg ttggtttact tggggacaga gctaaggtta tagcttctcc
51841 atttgacttc cttaYgtttg ttaaagacac ctccagattt gaatcttatt tggtttttct
51901 gaagcagggt ctctagaagg ttgtttaaat tgggtgtgct cttccgtgaa ttcgcRtatt
51961 acttatgctc actcaccatc tcagttgaag gctggtagta gtcaaatgac tcagatggtg
52021 aataccacca ttaaccttta acaggacatc tagtacatca acagtgggct ccccatttat
52081 ttctatttca aaaccctgag tccctctgaa tgtattcatt gatgtcctgt ttccaatttc
52141 attc ctttt agctYgttta cagagcagag ggcatcagta ctctcgaagg caatgagtga
52201 agagcccgag aattttagag catcactcct gtctatgtgc cagaggcttt ctgagcctca
52261 ttagtattgt gggcatggtc ttcttatcag gacagttaac aaaaccaaga tctccaaaac
52321 agacactaaa tattcccaga cacgagtcgt cccaaaggga gaggtggcaa tgttacccct
52381 agaaagaatt ataacaaagg gcaaagaaga gtagaggatg aggaagcagg aaggatctgt
52441 cttatgaYtg aagtgagRgg ttctcacaag tgcccaggat tggattgggc accggtgtgt
52501 ggtgcagtgc Rtctatactg gctgcattgg gacttactca atgaattaat ttttttggca
52561 ccaaatgtgt tcttagttat tgtgccatgt atttaaagat gtgcaaYagt aaatgagaaa
52621 tcttgggcct caagatgttt acaacacggc gtggcctagg gcaggtggca ataagctctt 52681 taatgagtat tttatagcca ctgtggaaaa cattatagtg gttcctcaaa aaactaaaaa 52741 tataacaacc atatgatcca gcaatcctac tgctggttat atacccaaaa gaaaggacat S2801 tagcatatta aagagatatg tgaactccca tgtatattgc agcactgttt acaatagcca 12861 agatgtagaa tcaacctaag tgtccatcaa tggatgaatg gataaagaaa ttctgtcata ι2921 gatgtacaat ggaatattat tcatccataa aagagaatga aattσtgtca tttgcagcaa ,2981 agtggatgga actggaggcc attatgttaa gtgaaataag ccaggcacag aaagacacat 3041 attgcatatt tttactcatt tgtgagaact aaaaaaattg atctcatgaa ggtagagaga 3101 agaatggtgg ttaccagagg ctgggaaggg tagtggtgaa gcggggataa agagaggttg 3161 gtta-atgggt aaaagaaaaa aatacagttt gatagtagga atgagatcta gtgtttggta 3221 gcacaacaaa atgactatag ataggaataa tttattgtat aattcagtat aactagagga 3281 atgaatttgg aatattccca gcacaaagaa atgatgaatg tttgaggtga tggttatccc 53341 aattgccctg atttgatcat tacacattgt atgcctgtgt caaaatatta cacataccct
53401 ataaatatgt gcaactatta tgtacctata aaattttttt aaaattaaag tgctctagag
53461 gctcagaaaa aaaaaccctc ttcctcccct cctctgccca ccccaccatc cagtgaggac
53521 tggaggatga ggaaagggct gaagaaggaa gtggtgtgtg aggtgggttt taagaatggg
53581 gaggactttt cttcctgtct ctctcttccc cttttctaat tctttccttc ctagagggtc
53641 ttctttggtg gtatgggttt gggctgcggt gaggcagaag ccaagctgtt ccttttcttg
53701 gatgtgtagg aacatgtttt cagggacttg aggttccaga ggagctggtt ctgctccttg
53761 gccatctcct gcccaccact taggctcata attactctgc aatgtactca tgaaacaggc
53821 tagggtgtaa acattctttc tgagactgtg cctctcgcac aggcacccag cctggaaatc
53881 aatggcacag aaaggatgag gtgagagttt ggctcttggc ctgtcttgtg gagccagcca
53941 tgctggcttc cagaggggac aactgttggc tctttaagga tgatgggagt ccagctgttc
54001 aactttgaat ggctgggaaa gcagttacaa tatgattgta atcaagaaMg ggcagcagaa
54061 ccagctggag aaggtgcccc atgaacatac tcaggcgcca cctctggaca gtctcatgtt
54121 gactcagcag aacctggacg tgtgtgtttt gaaagcagtt ctcgtccagt tgggtccatg
54181 ctgcgtctac caccggaaac tagggctctg cagactttta ctcKtataag ttcccaggag
54241 ctgacttgtt tcctaacaat catggtgcag atcagattat tctgctccca taccactttt
54301 ttgactttaa agaaatgttt aagcagtgcc ctcattgaca tccaaaacct ttccatttgg
54361 cattcataat gtgatctgta ttagtaaagt atataatgga ctctttgttt cattattata
54421 attataatta ttattatttt tttgctgtca tttgtagctc cggattttcg agcttacttg
54481 ataggagggc ttatcgcctt ggtggctgtg gctgtgtctg ttgtgtacat atacaacatt
54541 tttaagatcg acattgttct ttggtaYcga agtgccttcc attctacaga gaccatagta
54601 ggtaagtgtg tgtaatcact gaaaaatgcc tcaaaattgg tatcctctta tacatataca
54661 acgatttcaa atatactttg tcatatttta ctacgttgtt ggcaaattta gggaaaggaa
54721 tctccttgga actgcctgtg ctttagagaa atgatttgtc cctaatcacc agcatcattt
54781 ggtcagataa ggcttgcagg ctcgtagtga ttgaggaaat atttgctaag ctgcaggagg
54841 agatcatctt ctaagtcctg ctgcaaccat gttacaaaag tttccacgtc catcctccgt
54901 ccactgcggg aaagtttctc cgaaaccaaa gtgctctcca tccatgatgt gtgctcagca
54961 cagtgggtac tttctcagaa tctgggtcat ggagagggat gagctgcctg cggttggagc
55021 tctctctagg ccctgtactt ggtgcctgaa gRgatttaag tcttcaactc tcagatatgg
55081 agagagatca aaccaagttt gaatgtgact tctccactta ctccctatgt aaacttagaa
55141 agatgtttaa ctttcttcta tttctcagct atagaaagga atagaggaag gaaggaagga
55201 gacagggagg gaggaaagaa agagagagag agggaggaag gaaaggagag agggagggaa
55261 aacggaggga agaagggagt ttcgtagaaa agaaactaaa gaaagcaggg gagagagatg
55321 gaggagaagg gaggaaggga agaaagaagg aagggaagaa aaaagaaaga aacaaagaaa
55381 gggacagtga ttaaatcctg ctttttgaca gtgggaataa ctgagttgaa gtacagggaa
55441 gcattcagcg gggcctgggc cacagggcgg cctctattgc ttgtctggag gtcaaaacaa
55501 atccccaaca ccacagctgt gggttttagt ctgtgggcct atgtcctgcc agtgctgttt
55561 ggcatagaaa tgcctcagtg tgatcctgac tctctgagag cctggcattt cccaccatgg
55621 tgcttgtgac tatgctactt ttgttttgtt ttgttttgtt ttgtcttaga acagatacaa
55681 tctattaagg ccttgcaaaa gtaataaatc tgctctaaag tcccctaatt agatgaaaaa
55741 agaagcctgg tgcagctgat ctgtgtggag atgcacgact ttataccttt taagtccaga
55801 ggcctgagtg acaagagcag gaaagggagg gaaactggtt gtctgagaac gttttaNggg
55861 ccagctaaaa cataaaagag gtcactggca tcaagtgctt gctttgcaca taaaatacac
55921 agtacggttg ttgcccacat Stttgataaa acgtggctat tcactaactt ggattttttc
55981 caaattaaat ttctgaattc agaattagca accctgagca atgtagaaag cgataaactc;
56041 ctttttaatg acaaaagtca tctgaacctt aagtgtccag tgcaacctga agtgctgcta
56101 gtactgtgga tagtccgac'--" gggcatgggg agggggtctc tggttttggc tctggcatct
56161 gcagaggccg ccccgtctaa gcacacccat gactgctctc tcctgcttgc gtctttgaga
56221 agaagacagt tcagtccccc. accactgatt gttttctgac acagagttga gtggttcagt
56281 tgctttctac tttttgacta acagaagcct gcgtcacttt acgtattctt cctggaagct
56341 caggccccRt ggtgtgtσtc: tctcactgtc tctctctctc actgactctg tcagtgactσ
56401 tctcactgag tcattgcgac tcccaggagc gtgactatag ctgtgactta tgggtgttgt
56461 gcagtgtgtg gggaagctgc tagtgaggtc gagtttagca ggaagagaaa acaggaatag
56521 tgactcacac ggagtagtgg gggctgggca gatgagagag ttaggcagcc ccgccctctg
56581 ctgagactgg gacgcagccc agattctgca acagtgggca gaggatttgg cgatggaggc
56641 taacaggcag ccaggggtcc tttttttctt tatttttatt ttgcttaatt cagaaaagta
56701 tgtgtgcatt ttgtgatgaa attctcYaca gctctgtcta cgagaactgc cctgtaatat
56761 ctctgtgtgt tggctttaac agtgagctac tgatgagatt ctgagattag tcccagatct
56821 tgtttatgtc cttgttcccc ttgaggatat tttctgagtt aaatcaggaa ataccgatta
56881 atggatgaaa atgagaaaga gagaaataat gtccttcgta ggataagtca tttaccctga
56941 ctaggttagc taagctgtat cactcaatta ataattaggt gtgcatgact caccatttta
57001 gaaggagcca ttgacagccc tagctgaagt cagcaagttc tgtatcttct ctagcaagcc
57061 actggagctt tacaaattct cctggcaggg gtgcatgtgt gtacgaggat ggaagggtct
57121 gtgcacggat ctcctagaga gatttgaaaa tgcctcgcct tactccagat aggtctttgg
57181 agaatgtgca tgtaggatag aatggctaaa acgaagacaa gccaaacagt tNgagtgatc 57241 aaagggaaac caaggggaca atgggaaaac aagtcggggt agagttaatg acacctttaa
57301 caattattaa aggtgaattt gcttttcaag ctaaagcaaa ggcaatgaca agatccactg
57361 tgtgccattc acaacaacct ttcagatttt catgagagaa catggctttt tctgagacta
57421 atttccaaag gcagattttt tttcccccac agggagtcct catttcaaaa gggcatggtg
57481 tagggaagct tgactgcaac aactttccca tggtaaatgt catagcgtgt tttgtgtggc
57541 ttttcttcta gtgttttcta tgcatattgg gggtaaaccc accaaacctc ctgcagttca
57601 gtaaaagcat ttgcgtggag gccagattga atctgaattt tccactgttc tggtttcatc
57661 aggcctaaaa tttagcaata tcatattgag agaaagtagg gaattgaata atctttagac
57721 agtatttcat agatatgaat ttatgtgaat gagcttttat atattattgc caagatcaag
57781 aaggacataa caattttaag ggagtggaaa tagactctgc ttctttgcta gggtgtggca
57841 aagttctgga agaacatgtg ggactggaaa tattgctggg gctacttttg gaaaattcag
57901 actgacacag ctgcacagga ctaatcaggg attagttttg tgaaatttcc tgctcccatt
57961 tctcatttta gtcacagcaa aaggagcggt ggacctgggt ttacatcaag gctatgcact
58021 caccagctgg gagactttgg agagatcgca cagtcttgct ggtctcagct tccttactca
58081 taatttgggg atagaaccat gtcccacacg gttgatcatg agaagcaaag ccgggaaatg
58141 ttgaggtgcc gttgcctggc aaggctcttc aaaaccagtg gactacaact tgatctcttg
58201 ctattaatgt attggtcagt aaat tatgaa ttagtcattt gaaagtgatg aaaagtcact
58261 acgttttgag aacatcagca agttctattt ctactcaaaa gcttagtcag acagaaagaa
58321 aaaaaagatg accaaaaaat tgggcacatt tgtacatttt gaatttttca aaggtgtgag
58381 actttcttcc tactcaaatg tcttctgatc ctgaagttgg agagcaacaa gtacctatat
58441 cctcagacac cttgtttaga aacagggaac agggaacatt cgcaaaagag agaatacact
58501 tagcacacaa ggtttgtttg tttgttttaa aaatcagaaa cagtaggaaa aaagagaaac
58561 agattgagag aagagagata actagtggca gggtctggga caagtggcaa taagcctgca
58621 tgtctgctgt agtttagaat agaccaggaa acactgtatt taccagagag gttattctct
58681 gtggtgaacc gagcatcaac tcacccagcc cttcatcaga aaccaaagga ttaatatgat
58741 cacattttta agtgggaaaa ttgaattcct tctccaaaag ttcagaaaca taagaaactt
58801 atgaaRtgtt tcttttccca ttttctatct atggaaaaaa aatcctctgg ctttggaaag
58861 tcaaatgtgt gctatgaaat ttcacacaga aaagtatcca cttatttgag cggtggccct
58921 gatcagtgac ctttatgatt ccacaaggag tttcagctat gttgggtttt tgccaattca
58981 agacacaaat tagttatccc ttttgtacct gccctgtgat cccactttaa aaagctgagt
59041 ctgatctcag attcatcccc aacatagata taagctcttt gagcctccgt aaaatcaagc
59101 ttcatttgga tattcggtga gcactgatga aggcctcctc tgcgcccggt cctgctccag
59161 tggctgaggg cagggcaggg agccaacgaa gtctccactc ttacacagct tcctttcatg
59221 atggggtggg gaggcagaca aggagtgtgc acgtgtgtgt gtgcatgcgt gtatatgact
59281 acatgtgcaa gcatgggtgt gcatgcatgt gcatgcgtgt gtgtttgtgt taccattctc
59341 tgtaagagat ggccaagaat ggtgagcagg gacccgaagg tcagcagtgg ttggtgtgag
59401 aattgatgga ctgagaaatg gtgttatgta aactgtcaag atctgtgcac attttcatta
59461 ctattatttg gacgaaagct agaagaatac aaggttttcc tttcccttat taatcttaaa
59521 atcacctctt tctgcaagtc tgctcatcca acaaactctc atataaagga aatagaaaag
59581 gacaccaccc ctctctagta cctactaggc tgtctgagtt tctaaacagc ccaaagctcg
59641 aaatcgcgtt ttccaatgag acgcccacac ttacctcttc ttccactcaa gccctctggc
59701 cctgctgaag tccttattca ttcacaggat tcctgagtag ggaattattc ctccttccat
59761 gcccttctga agctgcaccc ctgσaagact gtttaccatc cactcttaga ccctcacttt
59821 tttcccctca actctcccac cctttaaaat ccaggagctc cagcctggcc aacataacga
59881 aaccccgtct ctgctaaaag tacaaaaatt agccgggcct ggtggcgggc gcctataatc
59941 ccagctactc aggagactga ggcaggagaa tcgcttgaac ctgtgaggtg gaggttgcag
60001 tgagccaaga tggcgccact gcactccagc ttgagagaca tgagtgagac tccatctaaa
60061 aataaaataa aaaaataaaa taaaataaaa taaaatccag gagcggtccc atgttcattg
60121 tgagtttttt ttttcaagaa ctccagacca tggggatttt tgattcttgc tgtcttttct
60181 gttcgtttga ctctcgtcgc ctcgtagagt cttgtgttta acttctgtgc atgtggatgg
60241 tctgcccagt gaggtcttgt tca ctcttc attggccaat gcaggggctg cttttgaggt
60301 tgctcaataa atactgatga cgacgacatg cgccattggg tttgacttct ctcaacggca
60361 ctgcagatta ctagagtctg ctcaattgct ttttctcttg tttcacagat gtgagtctgt
60421 gggtttgtag tgatggaatt cactggtggg cctgaatcaa gagggagtca tccagttttg
60481 cctggtgcag ttaggacagt gcttcgtcat acaggacacg ctgagggtaa catgggtaaa
60541 tggctagagt ttcctgcttt ttgtttgttt attttagaga tccttttttt gtttgtttta
60601 gagatgtggt cttattctgt catccaggct ggagtgcagt ggcgtgatca tagctcactg
60661 catccttgaa ctcttttttt ttfctttccga gacagagttt tgctcttgtt gcccaggctg
60721 gagtgcaatg gtgtgatctc ggctcactga aaccttcgcc tcccaggttc aagcgattct
60781 cctgcctcag cctcctgagt agctgggatt gcaggtgccc accaccatgt ctggctaatt
60841 ttttgtattt ttagtagtga cagggtttca ccatgttggc caggctggtc ttgaactcct
60901 gacctcaggt gatccacctg ctttggcctc ccaaagtgct gggattacag gcatgagcca
60961 catgcctggc cacatccttg aactcctaag ctcccatttc agcctcctga gtagctggga
61021 tttcaggcct gagctatcat gcctggctaa ctttttgaaa attattttct ttggagagtc
61081 ttgttatgtt gccgaggcta gtcttgaatt cctggcctca agctatcctc ctgcttcagc 61141 ttgtttatta cagccatgca ccactgcgct ggacgagtct Yctgccttta attctcattt
61201 ctggccacat cacagggagt ggtggactta g-actcaaaag acgtggggta ggggtagggt
61261 tagggattgc agatgtgatg cagcctaccc agcctcagct tcactcttga gcattgggga
61321 taagaccacc tccctcaggg gtccatttgt g-agaggagat gatgtccctt ggcagcccct
61381 ggcaccaagt cagccaactg ggcactcaga acgtcatggaa cccaggccaa aggacaccat
61441 ggtagccgct caggcttccg gtttattaac atgagagaat ttggtagcaa caattccaca
61501 agcttgtcca attccttttc agatgggaag ctgtatgacg cctatgtctt ataccccaag
61561 ccccacaagg aaagccagag gcatgccgtg gsatgccctgg tgttgaatat cctgcccgag
61621 gtgttggaga gacaatgtgg atataagttg tfctatattcg gcagagatga attccctgga
61681 caaggtgggt tttaagtgag gtgtaaaaat aacaaataaa agaaggaaag cgacccctct
61741 gttcctccac tttactaatg gcggtgactc tgcctgcctt ccccatggaa ccacagagag
61801 tctatgacca gcgccccctg cccgtcagcc cccagccccc agccaaggag gttaggccca
61861 agctctttgc ctgctctagg ctcctccctg cc_.ccgcagtg cctgagattc ctgcttgcag
61921 cagcacgcgt ctcactttga gtgaggatat ggttaagcca ttcacagaaa caggtggcca
61981 gtgatgtagt ggtggctaaa ggactgaaag gtggcgagtg gtcatttgag cctcacatcc
62041 ctgagatgaa ctgctgggtg ttttccatgg gtttgaacaa tgtaaatcag gtcgtgctta
62101 aagctgattt tataaacctc gaccctactt gccccctccc ctccctaaat ataatggaag
62161 ttttagtgta cttttcccac ttgataggaa ggtggctttg gacagttcag ttaacttctc
62221 tcaacctcag ttgtctcatc tgtaaaatgg ggatggggtg cttccctgac tcagatgaga
62281 gaactgaatg agaaaacctg agaaggggtc cc-cggcatgg agctcagcac actttagaca
62341 ctcacacaac agtgctttcc tgtccctttg ttctccttct tggaaggcta tacagcaaaa
62401 tggctgaaat ctgaaataaa cattcttttc tagtcaccag taaatgccaa ttcactcact
62461 tattcaacaa atatttactg aaaacctcta tgtgatggac agtattctag gcactagaaa
62521 tatgaaaatc agccaagcgg aagggcctgt cc-tcagggag gttccagtct attcttattt
62581 cccatgagag gcaactgtag actgaatagc atctgcagag ctgggtattt agagaaacct
62641 ccctttccca agcaatcatc agggcatgtt atttggtttc taaattactc acataaatcc
62701 tggtcattta aataactata aagaacaaaa ggaaaacaca gattcaagat taatgcaaca
62761 tttcagctaa ctacattttc ctatcctttt aεaaatctatt tttaaaaacg tgttcatctg
62821 ctaatataca ccagaccttc agctagtctg gggatacaga gttaggaacc atcagatact
62881 tgttggccag ggaaagtgac atacaaagaa accacatgca aaacatgatt catgactata
62941 gaggaccaag gctccaggga aagccacaaa ggcttcacag aagaggtgac aaatattaaa
63001 aaaaagaaaa aacccaaaac ttgaattaat ccattcctga ctaagtcatg tttattttaa
63061 agtccatttt tggccaggca aggtggctca cacctgtaac cccagcacct tgagaggccg
63121 aggtgggcag atcacttgag gtcaggagtt caacaccagc ttgtggtaaa accccgtttc
63181 tactaaaaat gcaaaaatta gctggacgtg gtggtacgtg tctgtaatcc caggtactta
63241 ggaggctgag gcaggagaat cgcttgaacc tgggaggtgg aggttgcagt gagctgagat
63301 tgcatccctg cactccaacc tgggcaacac agjtgagactt cacttcaaaa aaaaaaagtc
63361 aattttctcc tggcctgttt caaacattct cactagcatt aagacccggg ctgttttaat
63421 tgtgagttct tctgagcctt ctttctttat ttccagccgt ggccaatgtc atcgatgaaa
63481 acgttaagct gtgcaggagg ctgattgtca ttgtggtccc cgaatcgctg ggctttggcc
63541 tgttgaagaa cctgtcagaa gaacaaatcg cggtctacag tgccctgatc caggacggga
63601 tgaaggttat tctcattgag ctggagaaaa tcgaggacta cacagtcatg ccagagtcaa
63661 ttcagtacat caaacagaag catggtgcca tccggtggca tggggacttc acggagcagt
63721 cacagtgtat gaagaccaag ttttggaaga cagtgagata ccacatgccg cccagaaggt
63781 gtcggccgtt tcctccggtc cagctgcYgc agrcacacacc ttgctaccgc accgcaggtg
63841 agcgggtggg aggacacgag gtttgtcacg cactgatgga gggtctatca ttgcgtggtg
63901 gctcacagct ggaggaggac acgtttcatc ggggccgtct gctctgaagc tggcagttgc
63961 gtactagtga gaggatctgt tgtgtttgtt gtcatttgtt tgcttcgatc agagctgctt
64021 cttcagggaa acacacggct tctgcagaag gccctcttta gcctatgggc ttattgacac
64081 atgcccactc actgaggcct ggatggatac agrcacttggg ccccttgaga acaggacatg
64141 gagggtttta gaaatggcag tggacatgcc cgjgaagtttg cccatgatgt ggcacccata
64201 gagtctgaga tgggagcctg tgctgtcggg ggaccacagg agggcagtct agcaccagga
64261 gagggttggc aaggatagca gtatttgtcc ac-gcctgtcc agtgtcttca gggccccatg
64321 ctcaggggtc atttgctgtg tctgcgtctc tctcactctg tcagtgcaga caaagagctg
64381 caaacacagc cttagcactt tgcttccaga agrcaagttaa aagtcaccta gaccagtggg
64441 gacccacggg agtggccatg actgcctctt ggrtcaccctt ccatgtttga gaggctttat
64501 ctgtcaaact aaagcaagca ggaatWcctt tt ctctctct tttagacaca tgtcaaccag
64561 aattctgagc agcctgtgag agacgcaatt acrcacacaga tgatagaatt atagtccaag
64621 caaggcaaag tcagtttcca atgagccaat gtgcccttgt cacaggccaa tttataactt
64681 aatgattaaa ggtttttaat actaaaaatt agrctgtaaac cctcatcact tttttccaag
64741 accctggcct gagggaatta ggcatagctc aaccttctga agctgtgggt tgttgacact
64801 gagacttagt aagcagtcag tgggggctgg aagggagtca gccctgagag ccagccggca
64861 ggggYgagag agggagccag agggtgtcag gaggcctgtg gtcttaggat ggcatgggga
64921 gcagggtRgg ttaggaggtg ctgtgccctc gt tcacaggc gatggKtggt acccagtgtg
64981 ggatggactt tcaggtgcta aggaacccac tσctgtcttt gaagagttta tgttccaagg 65041 tgacctcaca ttacacattt gtttagcatc ctatgrgaggY ctcgacttga cattggtcca
65101 ctctttattt aacatttgct ttttaaaatt tttatttcgg taaactatat gaacataaaa
65161 ttcaccattt taacaatttt taagtggcat taagtacatt cacactgttg tgcggccatc
65221 accaccatcc attccagaat tgtttcatcc tctca-agctg aaattctgtg cccattaagc
65281 tatgcctccc tattgccttc ccattgcctt ccσattgcct ccccattgct ctgaggtagg
65341 acataaaata cattttaaga ataacagcat taaaa-aatgg ctactataat tcattactac
65401 tattacattt ttgatacttt tcaataaaaa gaaagrtagtg acacatgttg gaaagaggga
65461 agctttttga cttataaaac tccagttaaa gaatttacca acagtgctgg tctccgggaa
65521 gtcagaggtt tccagaaaat accttttcgt ctgacgggtc agctttctat tttgctgaca
65581 gcctcgactg atgtcctgtg agtgtggtca ttcatttata aataattaat tgctagagaa
65641 tccattttct aaaattcaca ggcacaccct tcagagagga cacgtccccR tacctctccc
65701 actctcccca cactgtggct gcctctggct gcctccatcc tgcagaggga aatggctggg
65761 aaggaagggg gaagggtgct gagatgccct caaatctgaa tggggtgggt gtattcccca
65821 aatcctcacc aaaccacgag ccagtgacca ctcac-rccttt gcggtccaga tcttactgcc
65881 ccggggttag tcaagtggcc agaggtggtg cccactgccc tcagggggtt tcctggcgtg
65941 gcctggtctc acatgcactc cgcagaagga aggacgaagc gtcctcagcc agcccgcagc
66001 caccctgccc actccagcac tgcaggcagc cttcagagac cagcccagag aagagaacgg
66061 cagcgagtga ggggacagag tgcggaacag atcagtaatg cccattttcc tcttgggtgc
66121 aataggagaa acagcctgtt ttaattaaac tagcgaatcc tccatgagga ataacgactc
66181 tcatgttgga gagagaaatc gagatgcaaa gaaacttttt aaagttcYac taattcctaa
66241 tgaaataata gggatgcaat gcagcaagaa tacaaataat tgaagtagcc tggcatcacc
66301 gctgacatgt aggcaggttg gcaggtaaca gctcc-gctca tggtctcaag tccaaatttg
66361 tataagaaag gaggtttaag agttcaacgg ctaacjggaca aaaaggtagt ttatgggaac
66421 gctgaaggcc accctcaatt ctctcccgtt tctcc-agctg ggcttggcgc aaatatgagg
66481 tcaatggggt cctatcccta gcccttgggg gtgggctcca gaattctact ccaagcaaag
66541 tgaagtcagt ttccaaggag ccagtgtgcc ttcatcacag gccaatttat aatttaatga
66601 ttcacaaagt tttttaatac tatgaattag ctgtεaaaccc tcatcactcc tttccaagac
66661 cctggcttga gggaattaga gacccccctg ggaatcccca gggactgacc tggaggtagg
66721 gctgcgagcg gagattggac cagagaggtg aaatεacaggt gctgagtcgc tgggttacct
66781 ttacattcac cttcccataa tgactgagtc agccacaaaa cccactacct ttggtatctc
66841 ccctcaaata ccctgagtcg gctcatgaga gaggc-tcctgg gaaagaccca gtcacattaa
66901 ataaagggac cgggaaggtg tggtctttcc ccggaaggacc aagcaagatg aagatataca
66961 tgtgaaaagt gcttggcaaa cYgtgggatg ccatgaggag ctggcctgcc aaaatatgga
67021 atgtgctcag ggagcctcag tccccagggc cccccacacc catcagcacc ccatagtgac
67081 gcagaccact tcctgccacg tcatggttgg ttgacctttc ctcggcactt ggtcctgttt
67141 tttatttata aacttccctc taacacatgc ttgtttggta ttgatctggg gctgtgtaaa
67201 gtggaaaatt ccttcctggt ttccttgaag aacagaggct gttccagatg aggtctggag
67261 tgagctacag agggtgatgc tggctttagg agtggtggct gctgggtctg aatgttagag
67321 gccacacatc tccagtagta atattattct gggagatggg aactctgtgt gtggatgtcc
67381 cctcccatac acccaggaac ttctgagaaa tgctgctgtt cactaataca attccaccct
67441 catctcccag gctgtccctg gagaggagct ctcc-acttga gaaggacctc agagccctgg
67501 ctcttgtcat ccaaattcac ctttcctctg gggctcttat aggaaaggtg agagttgaca
67561 ctgctcacct gtgatcctct ggcataacca ccttgcaaag ataacccaag agaaatggaa
67621 gcctcaggga tataccacca gatgaactga cggcaaaggtg gaggttttcg cattcccatg
67681 gcaggtttcc ttatcagccc ccatctccca ccacatcaga aaaggagtaa atagatcttt
67741 cctgatttca ggcccagaac taggctcaag aaga-aagaag tgtactctca cgactggcta
67801 agacttgctg gactgacacc tatggctgga agatgacttg ttttgctcca tgtctcctca
67861 ttcctacacc tattttctgc tgcaggatga ggctagggtt agcattctag acacccagtt
67921 gagctcaggc gtagagaaga ggaggatggg ataagaactg gggccatccc catgtcatgg
67981 tgggtgagag ctggggccat ccccgtggtc atgg-agggtg agagctgggg gttatcccca
68041 tggtcatgga gggtgagggc tggtcggggg aggcatcccc aagtcatggt gggtgagagc
68101 tcggagcatc cccatgtcat ggtgggtgag atctgggggt atccctgtgt catggtgggt
68161 gagggcgggt ggtcatccac atggtcatag tgggtgagag ctgggggtat ccctacatca
68221 tggtgggtga gagctgggag catccccatg tcatggtggg cgagatctgg ggggtatccc
68281 cacgtcatgg tggatgagag ctgggggaat caccatgtca tggtgggtga gatcttgggg
68341 gatcacctgt catggtgggt gagagctggg gggatcacct gtcatggtgg gtgagagttg
68401 ggattcatcc ccatgtcatg gtgggctgag cccacatgga agcctgtgct tggacagcgt
68461 atgccctttt ctctgttttt ccacaatgaa caa taaact gtaaatgtta aaaatatcag
68521 taatttgtga aataaatttt attctcattt gagc acata aatcacaatt ttgtttgttt
68581 accatgcctg tcaaaatcac aaacattttc ttat cagttt aaataatgaa aactgatttc
68641 tgctaaaatc atctgacaat tagcttgtca acat caaat atttttcacc ttaaatccac
68701 taccttcgtg gtgtggtcca ctgaaaagtt gggc aaacc caacctgtga ttgaggctat
68761 agagaaacat gagggtcatg cacaatagct ttttttcccc acacttagta gatggactgt
68821 ttctcagtct gacagccacc aaagctttat gtcctgatga atattttcgt cctctcatσc
68881 tctctgatgg cctcatttct ccaaatttct tct ctcctc cttttttttt tttttttttt 68941 ttttttttga gacagagttt cgcttttgtc accgaggctg ggattacaag catgagccac 69001 cgagcccggt caaggctttc atatttttaa aactttgaag tacagtgaga aacataattt 69061 agtaagcaac tcagtatgca cacacggaat ggaaaaagct ctgttctatg ttatttgttc 69121 tattttgttc aagtctagct caatttttca aaatgctggt cacacjctcgc caacttgttt 69181 taataaccaa cttatgcctt tccactgcaa tctggagagc tcagc:ctctc aggctgctgg 69241 tccccctgtc aatcacgata ctttggctac tttgctttct tcaatcaaca aggctttatc 69301 aagaacttat ggctctttta attatctgac ttcctggtca atcagctttg tttgtggttt 69361 taaatgacca caggatagta gaagtgaaca taatttcctg cctgtgtaaa aggatgacat 69421 caagaggaaa agaaagcagc tcactgggtg aaggaccttg agaaagagat gaacatttcc 69481 tctcttgaga cacaggacaa acaaggtcac gcctgagctc ggcaaacaag gacttcggtg 69541 cctgcctacg gcgccattgc gccctctagt ggctgctgag gaaccgctgt ccagcccgaa 69601 gctcacagag ccccgttcag gctgccgcaa cctacctagg cggccagaat ggagacttac 69661 aggtgggcgg gcatcccggg gtgcacacat taccttctcg gggctctcca acttaaggcc 69721 aaggatatct ttcttctttt tcggctgctg agaaggtgga gatagtgcca ttttcgaatg 69781 tgttcctaac tcttgggctt ctgagactgt cgcagtctgt ccaagggtgg tgagtgggga 69841 tcagcaggcc ctgtttacta tgtgctcgca agaggggact gcggtcatag ggatttcaga 69901 gaggtggccc tggcgtcggg cccctggact ccagtcacaa ctcaeiccact tgctgaggga 69961 gtatgctagc taaatccctc ttgcaagtca aaaaccctgt gccccagttt cttcctctgt 70021 aaaaaaggga taatacaatg ttggtatcct tattgcccac tacaεaaaagg gccagagaat 70081 atgaacagga catttacaaa gtaaggatta attcgtacaa aagcccggtg aacggaaaat 70141 gtgtgtaaca tcacaaatga tctgatgccg ccaggtaggg gggcεatttac catgtgccag 70201 acagacccta agctaagctc tttaagtaca ttatctcatt aacagtcaat tatcctatat 70261 cctctccatt ttaaaatgaa gaaagtaagt gtgtaagaga ttagataacc cacccagggg 70321 taacacagtt gttagacatg gccccaggga agtgtatcac cggctgggta tttcacgatg 70381 ttacagcatt ccttttaaat tgttaggcat gataatggta gcattgttat gtttctaaaa 70441 gcatcttatg tgttagaggt gacatactga aacatttgtg aatgaaatac tatgatgtct 70501 cggatttact tcaaaataat ccagtgcagg gagtggtgga ggacatgagt ttgtgaaaca 70561 agactgccca tgagtgaagt tcattcatga aaacatagag cagttaaaaa aatttttaaa 70621 aacaaagaaa ctcgcaaccc tcagacactt acgcaagtct gctgtgaaat aagacatcct 70681 ggctattctg aagagccgga tgaaactaag gatggagatt tttgttttgc tttcaaaata 70741 taaacagctt tttcctccct gattatttgc tcattgggta aatttatgaa aacaggaagt 70801 tataaaaata ttcattatcc ttttggtgta tatatgaata ttcacataga tttgatcttg 70861 caataccaat cttagattta tgaattgcgt tagtcagggt tttctagaga aacagaatca 70921 atatgacttt tatatatata caaaattaag aactgtctcc catgatcatg gaggctgaga 70981 aggcccacaa tccactctct gtgggctgga gacccaggaa ggccagtgaa atatttcttt 71041 agttggagtc caacaccctg agaaccagtg gcgctgatga tataaatccc ggtctgaagg 71101 cagaagatga gatggttcag ctcaagcagt gagtgaggca gatcttgaaa aggggtggag 71161 aagaattcct ccttcttctg ctttttgttc tattcaggcc ttgaagggat ttggatgatg 71221 cccacctgct ctggggaagg ctcactgtct tactgagtcc attgattcct gcgctaatct 71281 ccgctgaaac acccttacag acacgtccat aaataatgtt taat ctgggc atccttcagc 71341 ccaggcaagt tgacatataa ggtaaaccat cacatggatg tttaggtttg ttctatttgt 71401 tacttttaca aacaaagtgc attcatctga tcatttgcct tag aaatt actggaaata 71461 gaagaattta tcttttaaat agatctattt atatctgatc atttgatgca ttcttccaaa 71521 tttccctcca gaaagcttgt accagttgtg actcccacca atgσ tggctg aagatgtcag 71581 aaagcaaaac ctattctaag gtgtcccagg ctcaagcctg agtt cctagt ttggtaatga 71641 cactggggaa tttcttgttt tatatatttt ttgtgcattt caa agaaat gatcaagaag 71701 ctgtgatggg atgtttttgg tcttgaagga cctagtaata cact tctctg tttcaaggtg 71761 tggctgtgca attcccagcc ccactagtcc cctgtcttgt atgt ttatcc attgtacctt 71821 ctctgctgct ggtgattctc agtagggcac gttctcaagc aggσctccct aggggtggat 71881 ggtgccattg cttccatcca gttggatgga tcctaaaaac ttaacaggcc ataacacagg 71941 ggtggagaaa gctcagagct ccaaacaaaa ggggagaacc atctggcctt tcccagtacc 72001 tactctagta gagcaggtta attaaaaaca gaagcaacca taagracctga ctggtgttat 72061 ctcttttccc agccccaacc aaggcaaaac aacaaaaaaa gccc_atactg agactcaggg 72121 tcttttgtgt ttatgattcc catgtgtgtg gtcccagaga gaaagaggtt ggaggaggca 72181 ggggcttgag gtcagcaggc tgcagtggag agctgctttc ctgtgaggag gctgaagtcc 72241 cctaaaacga agagaaagct tgggatgttg ggctattccc gaccctgctt tcatgtcact 72301 ctctctgatt tcatttcaca tatcacagtt gacagggcat agatactctc gagacttttt 72361 ttttttttga gatggagtct cgctctgtca ctcaggctgg agtgccgtgg cataatctcg 72421 gctcactgca acctccacct cctgggttca agtgattcta ctgccgcagc ctcccaagta 72481 gctgggacta caggtgcatg ccaccacact Ygactaattt ttgtatgttt agtagagacg 72541 ggggtttcac catgtttgcc agactggtct caaactcctg acctcaggtg atctgcccac 72601 cttggcctcc caaagtccta ggattacagg catgagccac cacaccaggc tctagagaca 72661 tttctaaagg ggatgcttgg aatcttgaga agcctgtagg tcttcttgta ggcaatcaat 72721 tatctgctca ttgaagtaag aaagccaagt acttgattgg gggcaggtgg gtgggcaatg 72781 gtaggacatt tactcccaga ccccatgctt gaaaatcaat tctctttcca gttttccaac 72841 ttttctgttt taagcaacat cagtcaggtg tcagaatgcc cacaaagctt ttctgattga 72901 atgagtaata ggtaggctct attttattct gtgtgaaaat taagggtctt tatctctcag 72961 ctcttaccat ggccaataaa taaatgcttt ggaaggtaca gctgtggcct tctctggaat 73021 tgaggaccct cagaacactg ctggcaccct agaccttcca cagagcttgg cccaatgaat 73081 gaatgatggg aacttggacg caagagcaat ggtgagattt gctcgggtct ctc-ctgccca 73141 agttaatttg catatctgtt gtatggcttc caagcaaggt aaggacaatt tggcctaatt 73201 ttatttgtat ctataatcca acctaggggt ttgaaggaca aatatcaaac agtggcagat 73261 ttctgtttca gtgttgagca ccgggtgtcc cttcaggcct tgttcaaggc agctcccaag 73321 agtccagtgg gcaacctagt gttaggaggt tgcctgtccc atctctctag ggtatgagac 73381 caaaagatgg gctttgtttg gtttcctgga aaccttgcct ctgtgaaaga gc-attcaggg 73441 atctcaaagg accaatcttg tacttccctc catgccacct gtctaccttc caagccaaag 73501 gtgcatggta gccactttag ggggaaatga gagaactcag gtagtcattt agccatacta 73561 ttcaaaagtc ccaaactggc cttttgtagt tttgttgtca ccttctgcca ctcattgaac 73621 acatgggcct cctatataga tacagaggtg agcatagagg catgtctctg ccctgatggc 73681 atgcatgatc taatagatgg aggagacagc cacaaggaag gggtgggaag atggctgggg 73741 gtaggggagt gaggagatgc agagagagag caggaggaaa atcatggaag aaagccattt 73801 gatgagagac tctctttttc tctttctttt taaaaaatgc aacactagtc ac-aaggggtt 73861 atggctgacc tgactgtgac acccccagcc cccacctgag gaagaggcaa cagctccggc 73921 acctgtttct gacctagggg ccaggtgatg gcccggctcc acaccacatc aggcctgagt 73981 gtgggaaagc gttgcggcca ggagccatct gggagcttga aacagagctg tgctctcctc 74041 tgagctgtct ggtttcaatt aaacccatgg ctaaaacctc caccaggcgt gtccatttgg 74101 gacattgttt tggcttattt agaataaata atctatcgtg gttttccctt ggtactcggg 74161 gaaattgtcW tcgggtgaaa ctagcctgaa ataagtactg agatcatgct tggaggtccc 74221 gctggcccgt ggggaggggt ggcggtggcg gtggtgcggg gtgRagggag ggtcggtcct 74281 gctttgctga ggacggagcg gcctgggaaa gaacggcctg tcttcagggc tcI tcctcgc 74341 ctcgctctgt ctgcccctga gggtctgtcc gccacaacac gaaccctgtg gatgttccag 74401 ggaggtatct ggtagtctga cctcagtgac aaagaaggga ccttacaacc cacggcagatg 74461 agcagcgtta agtcccaaac ccaagtgagg gctccagcga tWgccccacg tgtcccccag 74521 ggagcgccct ggtgtttttc cttcgcttcc taaagggatt ctaaaaagaa catgcaacct 74581 tgatttgtca ggaagcaata aaaatgcatg cagagagctg actggagccc ggsattgtaca 74641 tgcctccttc ttgcctcaga aacacagagg aatgaatgaa ttaaagacac aacaσtcagc 74701 cctaggcttc aggattggat gggtgaacat tttggggtag Kcttttctag ag-atgtgcca 74761 tcaaggtagg aagagtgtca aatgaaatct cactttataa tcacaacagc cccatagact 74821 gttgtggcaa gtggaagaga ggtgtagcca ggtaattgag ttcaaggcag catggtagaa 74881 acatgatttt ttttccccaa agtcaagccc tttttttcca ttaggtagaa gctcccttca 74941 gttatttctg ctaggtttca tagttttgca gtcacttctg gtgcttcgaa gagtcatttg 75001 gggtttatca gattcagctc tggttcatgt taaaacttta atcatttgat tccraagcttt 75061 tcttttcctc tactctgctc atgggagatg ggagctgaga ctagtgggtg gasitaaaggt 75121 ggtgatgggc tgctgtcaca cacctgtcct cttcctccat ctctcccacc tcsitttggag 75181 cagtgagaga taagggaaaa aaccatgtct acatctttga ctacatatga tggctctgcc 75241 tggggtacca caactgccat ccctgctcat tgcccaaggg catcaagtgg atggatggtg 75301 acaccttcat gtcctacaag Rggctcatat ctgaggagag accctggcaa aggtgggttt 75361 tggagggacc cagctgtgct ttcaggcggc catgcagtgg gtggcctcac atgcacacct 75421 gtggggcctg tgctgctttg tgcctggagc ttctagctca gtttcccacc acsigtctacc 75481 ttcaggtctg caggtgcgct ggggctccat ttccctactt tcttaggaat cagaacctct 75541 ggtggcatgt gcccaacttt gaggggagca tgcattcatg gcccactcca ttgggcaggg 75601 cctcaccaca ccacctcttc tcaagtctac ttttctctag ttcagggact cacgggacaga 75661 cagtacagtg aatctaccag ctaatcaggt gcacagcagg aatcaaaatc cagtcccact 75721 ttattgatgg cactcaaagt tttggaataa ttctcttggg gatctcccct caccccggta 75781 gagtgaggaa gaaataagct gttttcatga accaaacaca aaggcccaaa gacgacccgt 75841 gagctctcct catatgtgga gtggttgttc attggggtgg gggtgtgggt ggggccagtt 75901 cctagggaac atccctctca gtgggcttgt ggctggtgct cagcatgttc tgtcttcagc 75961 ctcagcctct gctgaagatc ttgaacaaga ggaaagatac tgtgtggcat ctgacaccat 76021 attttctaaa agaacttctg gaaaccaaag aaaaaagaca atagaaaaat ggacaaacaa 76081 tataaacagg aaattcaaag ccagaggaca ccaaataatc aagacccata ggagagccca 76141 atctcactaa taataaggga catgtcatta cacaatagtt actgctttat atcttgcaga 76201 ttagcaaagt ttaaagggcc tggcaatgtt ggtgaggtca tggggcagta gggatgcttc 76261 tctgttgaac ttactgctca ctggtagaat cactgtggag agagcattta gcccataatgc 76321 tcatagctgt tctaggcaca tagcctaaag aagctctcat tcatgcaaat aagggcatgt 76381 gcatacgaat atttattgat gtgttatttg taactgtgga attttggaag cagactaaat 76441 atgtctgtgg ataagagtac agagaagctg tgtacatccc ccaaatccac tattatctgc 76501 agtttaaaaa gaatgaactt cagatacatg tatgaacatg ggtaaacttc aacgccatgtt 76561 gataaaaagt ttcagaataa tatgcacaat atttatatta gttatatata gccaaaatata 76621 acatacaaaa cagattctaa gattgtctca caaggttact tgtgagttta tcεatagtctt 76681 attcacttcc agctttaatg taggatgctt ttgttacctt attctgggct caεagcttttg 76741 ggaacagctt atatctgaaa caccaaaggc cattgattct atgtcccaaa taaaagcctg
76801 ctattggctt gaatgacaat aacagacttt tattattgac aacaataata aaattgatgc
76861 ctattgcttg atactgtgtc tcagttagac ctggctttct atataggcag ttacctaccc
76921 agtaacattt tagagatgct gaaaagctgt gttgctctaa aacatctctg gcjggagacca
76981 gtctactact acatacattt ctagaattaa aattttaaaa tagttaatgt atgcaatcag
77041 caagagtatt ttattaatgt ctccaacagc ttcattcaca cacttgcaag ggrtacattta
77101 tttgattgca tttcaatttg atggctgaga tagaaaggag acaaaatgga agctttgtta
77161 taggaaagga gtacagaatt gacatttagt gtgggctgct gtgggaagaa ggjcataagtg
77221 ggcaccactc tggggatgac gttacaatgt tctttggaca aaaggacaag gaaggacaac
77281 tttgaatgaa tgcaggtgtt ttgtctaaac atataaacaa gtcacagcaa actacactcg
77341 gcatcatgaa atggtgctgc tgaccactat agggattcat gttttgttga gc-atttagta
77401 tgtgccaggc agtggctgca caagccttta caagaacctt ctgaggtata tattgcacat
77461 tcctatatat caggctttag agagttttga tcgctttccc tagtactcca tagtatttga
77521 acccagggct ggctgactcc aaaattcaat aagccatagt gcccctaagt gacagtttcc
77581 ctcctactct atagtttatt cccggagaat gtgtaagttt gtaatagact acactttggg
77641 tatgagcagt acattttctc acccttcctt tgattccact aggaagcttc ctgtgtgcat
77701 ttggctcctg tgagtccatg cccaggcttg gtcaacccta acatggtaca gc-ttgcacag
77761 tttgtaggca gctttgcaac acaggataga tgaacctaaa tcctcggaga ttcttttcag
77821 ctggattagg tgggaaaaat tgtctctctc ttgctccctc tcctactctg tcrtctgaaat
77881 gtgggtatag ctttgctggt agcagtcttt ccttccacaa ggatagattt tgttagcgtc
77941 aagaatgaat catgtcaaaa gtgaagagtc aagagataag cagaatcaga gεaaggaaaga
78001 gagaccaaga gagatctgtg acattgtttg agtccctgga tcctgtcatg cctgaattcc
78061 ttggaactct gaagtttagg agttaactat ttctcatttc tgcttaaatt tggtttctgt
78121 ttctcacaat ggaaataatc ctaacaaata caagcctcaa tatgttagtc ttttcctgca
78181 gacttctttc tgattgatat cactgtagca atgtgaattt ttctatgaaa tcatgtaagt
78241 ttctctcctt ggaaaagaga ttaaaaagcc atactaggtt tggggttcct atcataagtg
78301 tgtttgggta taaattatac aatggctcaa aagtaacata aaaaatttat ttttgggggc
78361 agtgcacact taaggcatga aatccggcgc ctcagtccac tgctgggatg ccactggtgg
78421 ccatcatctc ctcccaggct ccacatctga gccttgtaca gagcgatgtc attgcagacc
78481 ctgcagtggt tcagcctgca atctgggcat tctgggttga ggggggggca ctgagtccca
78541 tgcactttcc tggttttcgg tctgtgtctg ggtccctctt ccttggtccc tgggcagcgt
78601 ggtgaatgag attccgaaac ctggcgtctc caggctcctc caggttacca tgccaagaca
78661 tgggcttcct ggtgatctgt ggacctcgtg gaggggttca cgtgataccg cgcatagacg
78721 ttctgggctg gtagcccttt gaggtacagc tcctgcaaga tctggttctg acggacctca
78781 tcctggatca ccttctccct ggggtgtccc gccatggcct tggcattgct ccatcgggtt
78841 cgatgcgctc tctgctccct tgtgcctctc tccctggccc cgggcttctg ccttctccag
78901 gcaacggtgt cccacacggt ctccaggcta cagcactccc acagccccag ctcctggcga
78961 cccagccctt accccaaccg cccgtggaca cctccaggaa agggcttcct gtcacgggac
79021 agacccggag gtcatgggca tgtggttagg cctcaccttg gccagtcgtt tctctcccag
79081 cgagcagagg cgctgcttcc tcgtgctctc ccttctctgt ctcgggcctg cεagtttgctc
79141 cgtggttcca gaccaaggcc cacggggaag ccattgccaa atgcagaggc tggcgcggct
79201 ggctgagcag gcagcggagg ccgagggtgg gtgtccgtgg tcctgcgtcc ccgtgtccac
79261 agccaggccg cggggaccct agggtccgct ccttcgctgc ccgagcacgg tgcctgcagg
79321 ggcccctccg tggggtcgtg gatcgtcagg gccgcgtggg tggctgggcg ggggcgggct
79381 gtaggcagct tctaaaagca ggggctgggc gggggcgtgg ggggataggg agggacgtag
79441 tggaagttgg ggccccaacg gacatgaggg cggcagatgc agatcttatg aεagattcagg
79501 caggaagagc tcggcagggc gatgcccaag acggggtagt ggacggggac gεaattggttc
79561 agagacgggt agcagatggg gcagaaggac gagtaggtgg gctggaacag g-agcgtagtc
79621 tgcgggtcca gaaacggggg acggatggga ggaaagaaga gccgactgcc agggagctgc
79681 ggggtggcgc cgagcgggcg ccggggttgg gaggcggaga ggcggggcag ctttcgagtc
79741 attttcagcg agtgcaaagc tccctcgtcg gaacggtcgg agtgcgcggc gagcgcgggg
79801 cctgcgcggc ttttatctcc tcagggcgtt ccagggcgga acgtgctttg tgacctgcgc
79861 cccccgtgaa gccgggagcc cctcgcgagt tggcacaggg ccccgtctca gggtttagga
79921 gcgaacgggg aaatggaaga caaaggaaat ggggggacat agcaacccct attcttgtac
79981 cctgtagttt tgccctcagt aggcaaaggc tgatcagagg gctaggatac agttagaggc
80041 cgggggcctg ggggagcggc tctgagcagg atctgggaaa aggggacgaa gtcagtgccc
80101 caggcacctt cccttaagac agcgcagcgt tcaaagccct tcagtccttc a catcactgc
80161 gggaacatgc gcaattagac atgctaggtc cattttaccc atgggacagg a-aggaccaga
80221 gagggaactt ccataggctg gcggtggtga caaagcaggt ggggctagaa cttgggtcag
80281 gagagggcag gtaggaggga aggcaaaatg ccccaagcgc gcaccagcgc cttgcctctc
80341 ctgcatgtct ggacggggtc ctgcaggggg cgcgtcagag cagacctggg cgtttcctag
80401 cttacccttg gtccccgtat tccttggttt gaagctttac tctttaaaat acttttttta
80461 aatctttaaa tatttatttt atttcatttt agattcctgg gtacatgtgc atgtttgtta
80521 catggatata ttgcataatg gtgaggattt ggcttctagg gtacccatca ccaaaatatg
80581 aacattgtac ccaataggta ttttttatcc ctcactacca tcccaccctc ctccattttg 80641 aagtccccaa tgtctgttac ttccatcttt atgttcatat gtactcattg tttagctctc
80701 acttttaagt gagaacatgc agtattgtac tttctgtttc tgagttattt tacttagtat
80761 gatggcctcc agctccatga tgttgattca acggacatga tttcattctt ttttatggct
80821 atatagtatt ccttaccata ttttctttat ccaatcaact gtggctggac atttaggttg
80881 gttccatgat tttgctattg tgaatagtgc tgcaataaac atctgagtac aagtgtcttt
80941 tttaatgtaa tgatttcatt tcctttgggt agattcccaa tagtaggatt gctgggtcaa
81001 atggtagttc tctttttagt taattgagaa atctccacac tgttttccat agaagttgaa
81061 ctaatttaca tccccaccag cagtgtataa gcgttccttt ttctctgtgt ccttgcgttg
81121 tttttttgac tttttattaa cagccattct gactggtgca agatgatatc attgtggttt
81181 taattggcat atctctgatg atgagtgatg tttcatgtgt ttgttggccg agaaacaact
81241 tttaatgtat ctacttggca taacctagcc agacaaatgc tttctatagt tatgaaagcg
81301 gaattaaatt tgaaccaata aatgtcataa tcctctacta ctccatcact tctccccact
81361 cctagacaca taagctttag gaataagtga aagagtgagg gctgatccct aatgaggcag
81421 tgtggagcag atgggctatc agtgggtctc ttcaggctat tggctggtgc tagagaggaa
81481 gggcacaccc aggaagggac tggggctgtc actggtacac ttgggttgtt ctgatggtgc
81541 ttcaaaacac aagaacaagc caagcaacca cacaaatggg ggctaagcac agccatgctt
81601 tgggttaagc gggcatattg tcatcaaaga cctctccacc tttctctgtc ctgaagaagt
81661 ttgcccagat tgtgagcaca gcccgtcctg gttccatctg gggagtttgg gatgcttaga
81721 aaatttcctt ttcatacctg acatgcccaa ataaagagag atctctttct ttttctcttt
81781 ttaaaaggcc tgatttaaag actgcttaaa tcaacataga tgaattagat aagtcattat
81841 gcaacaatgc cttttccata atgactcaat ttctgaacat ggtgtgactt ggtgggttgc
81901 gttttgctct ggttgttcta aggaggggag cttagggcaa tgacctggga cagctctaag
81961 attttgcctt ttcttttagc tggaaccatg tgctagaact atcagagtat gaccaagttt
82021 tccttttttg cttggtttga cattgctgcc taagataaga catacagtac aggctgcaga
82081 aacacacaaa aattctgctg ataatacaca cttgtttcta tggccaggaa gccctgattt
82141 gctcacctcc tcaccaccat gaccaggtgt gaattcacag gtaaaagggc aagtttgttt
82201 actcctagtt gctcttgaat agagagttga ctttttcacc cccttggctt gtaactgctg
82261 agttcactaa taaacccttc cttttaaaag gggggaaaat aaaactaatg agaaaatatc
82321 ataggagata aagaagaatc ataagaaccc attgtggaag ttcaaaaaga aaccgttgaa
82381 ggtctaaaag ctcagaaaaa tatttagatc actgatgcta taatagattt aagtaaaaca
82441 gacaggggcc acaaagggta acattctaga atattttgaa caataaaatt tagtgtaagc
82501 cacttgaggg caccctttct gctctgcata tctcaataga ggctctactt ataaacgYtt
82561 tttaaaatct ctgggcttta aatttcttta tgccaatttt caaacagatt attgaaatct
82621 gactgaagaa taagcttata aacatcccta gtaatatatc catattgtgt ttaaaaagta
82681 tttttgagtt gagatcaata aactggtttg aagtctaagg tttcaaacat aagtaagaca
82741 tgaatcttga aaataactca attaagaaat aagtagaaaa gatttcaaca taaggcaata
82801 aaagataccc tccttccaca gcgaaatatc accttcaacc aaagtttctt tttcttgaat
82861 caattttatt atgtttaatt ttcatatggt gtaggaaggg caagggaaat ggggcatggg
82921 aggtcagaga gaactttctg gagaatgtga tccccacata aaggaatgtc ggctggaaac
82981 ggtggatggg gtggaggtgg atgtggccga agaccttgtc tcacacgaag aagaagcata
83041 aaatcatgag aagtgttcag agccccacaa agacttcaat ttctcaaaac atgaagtcaa
83101 gaatgaagag gggactagaa ggtggaggtt ggggtgaaga actcaagaac gaggagaggg
83161 agaagggtgt gggagccttg aacaggcaca gctggagaaa gacttagtgg tattacattt
83221 ttaaagattt ctctgctcat aaatacttga aaaaaaactt gaaaatgcaa aaagcacaaa
83281 gaagtcatcc ccaatcctgg aatataggca taaacacaga ctatttttat tttataatgt
83341 attttaacat ctgacaatac cagccacctt tatcgttata cttttgtcta cactttcttg
83401 actctttttg ttcattcatt agtgtcttaa gtttctattg gtattttgat tttaattgtt
83461 ttgaatttat gctaacttac aattttatgc ctctctagaa acaggtacta tctcttaata
83521 caatatttct ctaatatctc ttaatataac agtacttttt cacatagatc ctggcttaag
83581 tttctttaaa atttcttctc agaaattgtt ttgttgttgc tattgggaat gtttttttcc
83641 attttttttt ctcatagtta cttccaggct gatgaaatcc tggtttttct acttttattt
83701 taacttgtca actgctgttt attttatttt attggcagat ttattttgtt tatatagaca
83761 atcataaccg gaaatagtaa taaacttgtc tttttctttc cattatttgt ggagtttgtt
83821 tcttttttct gtctaatttt tagactgtct aaaattttgc ttaataggaa tgagagggga
83881 catatctcta tggttttact cttagctatg atgttggctg tttttatttt ctttaaaaat
83941 tttaattatt ttacatttaa attgttttaa attaaatgat cttctaggct tagttgacta
84001 aaagctttaa gttttgaaaa tttgtattga attttgtcat aggagtcttc ggcatatatt
84061 aagatgatta tatgattttt cttctttgac tttttggtat gatgaagcat attgatacat
84121 ttcctgatat taagccatct ttgaattcct gagtatacag tgtacttata tttgttaatg
84181 tgcttcattt atctaatttt atttggaatt ttcatttata tttgcaaatg aaattacgaa
84241 tgaatgttta catttactaa ctctgtcctg tagaaattat gctggcttgc caggtgtggt
84301 gactcacacc tgtaatccca gcactttggg aggctgaggt gggtggatca cctgaggtca
84361 ggagttcaag accagcctgg ccaacatggt gaaaccccat ctctactaaa caaaacaaaa
84421 caaaaacaac aaagaaacaa caacaacaaa gtagccaggc atggtggcag gcacctgtaa
84481 tcccagctac ttgggaggct gagacaggaa aatcgcttga acccaggagg tgaaggttgc 84541 agtgagctaa gaaagcacca ttgcactcca gcctaggtga caagagtgaa actctgtctc
84601 aaaaaaaaaa aaaaaaaaaa aagaaaagaa aagaaattat gctggcttta taaagcaaat
84661 tacaaacctt ttcatctttt aataagctct ggcagtgtta atataggctg gaaattattt
84721 cttctttaca gatgtgaagg caattatctg agtcaggtac tactttggtg attattctta
84781 aattatattt gttatttcta acacatttat tgatttgatt cttttttatt tctttaataa
84841 taaataaaag tttggtaatt tactcttatc tagaaataat gcacatataa ttttctaatt
84901 aattactata tggagatata atctttctaa aagcagttaa tgttctgaat gtatattgtt
84961 ctttgtttca tctctaactt tgtttacttt cactttcact tctccctcct gtgacttaac
85021 taggcagaga tgcctatttt accatctacc ctctattcca cttgaattta tcaatgcaaa
85081 cattttctct taaccaatta attttatctt taagtccttc tccctctttt ttttcaagtt
85141 tatttgtgac tctcatgatt gttttctaaa ttctcaggat aagtacttag caacttcatt
85201 caaatacttt attttttttt tttaagaatt aaacaattgc cctcccagta cagctttggc
85261 tgtattccag aagtttgcta tgcagcgttc ttctgggtat tttattaata ttgagatact
85321 taagttttga tttttgattt ttgagtttca ttttaaacaa tgttgNtgcc tttctttttt
85381 cctagcggtt cagtttgttt gcatgtaaca ttgttaatta tttctagcta tatttcatgg
85441 taatcagaaa acagagtctt taccaatcRt aatataatgt taagtaacct cttggcataa
85501 ctactgtact tctactggca ttagaagcaa gatgataatt ttcctattat aactttagtg
85561 tccagtttcc acattctcac atttctttac tcaccaattg ttaactgtac gggacaatgt
85621 tgagccaagc atgacgggga cataattgag gactgcagtt aatgtgctgt tgccagagag
85681 caaatgtaaa agggatcttc accattagcc tgtctcaccc tttgcccctc cgcgcttagg
85741 ggctggtaag ggtactgtca cctcaggggc aagagatgat gaggatttgg gctataggtg
85801 ttgaggattt gggactctgt tgtaagtaga agctggctag gatggctgag ggttcaatct
85861 ccttggtgga agacccaggg agactgtggc agtgaggggt gagtctcagg gaggtgagtt
85921 gctacccata caagcaaagc tgcttctgga gggcacactc aggatatcac agaggagtct
85981 ggggtccccg tcttggtgtc tggaatgagc actgggtcag gagctgatcg agtgtatgcc
86041 tctgtctgcc ctggtcttgc tggccattag caatgccact atgtggagtc actctctttc
86101 cttagggcaa tcaacacttt ttcccttttt cccctaaacc tacccttcta aggaagacac
86161 tgttggtgct tcagaggtgg tgtgactttc taaatgagga tggcctctca agaaaaccca
86221 tgtgattttt tatcctaact tatcttacat catagtagaa acttctctca ttttaaagga
86281 ctgctgctag cacacaaact caagttcaat ttctgggtag tgtccctctg gtagggtcac
86341 tcattacaaa agaataaaga aatatttcct gcatctttat tttctcttat gttggggcca
86401 caacaaaata atcacattta tgcctttaag cttctaactg caccctagtt gatttgctat
86461 ttgtatattc ttctctaata ttgtMtgtgc ctgtttaacc atctctgagc actcttttcc
86521 taaaatgtac attcctacac aaagctaata tcccattgcc tattaaaaag tatccaaaat
86581 ttattgagaa gaatgtcatt tgcatttaaa aagtcaactc cttgcctggc aatctaagac
86641 ccttctccct tatcctgctc ataattctac tgtctatcat tagttctttt cagctaatca
86701 tgctccaggg gacatgatga catttggcaa ctggagatca gtttcatgga ggtcgggtcc
86761 tgttacatat cccacaatgt gcagaacagc tgccgcccac aacaaagaag tgccaggccc
86821 caatgtcaat agttctgagg ctgagaaaac ctgctctaga caatgaggga aagggatgcc
86881 ctcagaacca cctgggggat tcccaccaaa tgattctgat gtgccccatt cctggtttag
86941 cataactgtc ctggaacaga gtaagttcat ctcctgaatg aagttactct cgtttctcca
87001 aacaccatta actgctcttt cctttggctt aattatatca ctgtagaatg gtttccagga
87061 atggcaattt tctttgattc tctcctacat gcacactctt tccattggag ggtctccttt
87121 gggaagatta agtgatgtga gaagcatgca gagcacctgc ctcgtcaccc agagtgtgag
87181 atcctccatg aaagggagtc tactctcctt cctttttctg tagtttaagc actttggaat
87241 ctgaggccat gcctcatgca actcacagca acacaggaag gcactcatct acagagtcac
87301 ccagtgagtc attcatacta aagtaatatc tcttttcatt tcaccatcag gagtagtaat
87361 gtggattcag taacaggcaa gtaacactct caaaaccaca agtatctcct gagagcagca
87421 aataacagag ttaaaaactt tcctttctga gaacattgcc tttctcagaa acgaaggtgc
87481 taaaatcact ttttcttgta aagtggtgat tggaagtaac cattgatcac aaatgctaat
87541 tcagcttctc taaaagacat gtcatctcag acatggtctc taggctattg tacccttcct
87601 ctcaccaaac acacatgcag gtaatcctct ccatgtgctc aagtctggag aaatgatata
87661 tctcacaagt ttacaccttt tctttaRctg aaataaatgt aacctgaaat caacacaaaa
87721 tccaaccatg tcttactgtt attcactaaa ggttcttaga accacaagat tacagtattt
87781 tgtggctact gggaggtatt ttcatttctt tttcacaaaa agacccagtt atttgactgg
87841 taccatcagg gttgattttt gtgtaaaatt gtgttttagt gtctcttaca ccccacacat
87901 acatagttaa tttatcaggg tccttgttat tatctcctct tctttgtaaa gttagactta
87961 aaaatataca agttttgaaa tgaacaaatg gctgtgaatt gattggctga gaatggtttc
88021 ttcatggaat agaagaaaga caagcgctct tttcactctg tgttcttaaa cagtcttcat
88081 gcttagaata tgattttaaa tttaaatacc tagttctcct atccataatt aacttgaaat
88141 gattactact taattttcca cctgaataca tcattttctt ttcctttatc ttttggatac
88201 atttttattt gtgtaccttc catgggtcaa tttaggaaag ttatgtacct tctttggccc
88261 ttagtttcct caaatccaga gtgaggggtt ttgactacat tagtggttct caaacctgac
88321 tgcacagaat aattaactga ggagcttgag gaaatacata atgcccagtt gattctgagt
88381 gagacccacg gggcagatca actcttagat tatttccaac cttaaaattc tgtgctctga 88441 caatacccat tctggcgagg ctggtgaaat tggcgagcca ttgatctcaa atggaatggt
88501 tagcttggtg attccagtgg cccgtttcat tacaggtatc aaaaaatctt taaaaagtac
88561 ctaactttgg gccaggcatg gtggctcaca cctgtaatcc cagcactttg ggagcctaag
88621 gcaggaggat tgcttgagcc caggagttcg agaccagcct gagcaatata gtgggaccct
88681 gtctctacaa aaagtttaaa aattaaccag atgtgatgga gcccggggta tcaaggctat
88741 agtgagccat gattgcacca ctgcactcca acctgggtga cagacagagt gataccctgt
88801 cacaaaaaaa aaaaaaaaga aagaaagaaa gaaaaagaaa aaaaaaagaa aagaaaacaa
88861 cacctaattt ttgaccctgc agttctactt ctaggcattt attcttaaga gattattaat
88921 ggtgtgccag atatctagtt ataatgatgt tgactccagt gttatataaa acagaaaaaa
88981 tgaaattcgg taatatttaa ataaattatg gtacaagcat acaataaaat atgatgcaga
89041 cattaaaata atgttaaaga aaagtattta tgtcatggga aactatttat agtataacac
89101 atgaaaaagt tggtaattta ttttaaaaat taataatgtg gccaggcaca gtggctcatg
89161 cctgtaatcc ctgcacttta ggaggccaag gcgggcagat cacctgaggt caagagtttg
89221 agaccagctt ggccaacatg atgagacccc atctctacta aaaatacaaa aaaattagcc
89281 ggctgtggtg gcatgcgcct gtaatcccaa ctactcggga ggctgaggtg gaagaatctc
89341 ttgaacctgg gaggcggagg ttgcagtaag ccaagatcac accactgcac tccaactggg
89401 acagcaagag tgaaactcca tctcaaaaaa aaaaaaaaaa aaaatatata tatatatata
89461 taKaataaca tttgtaaggt tatagagcaa aatgatgaca aaggtttgag tggtgggatt
89521 acaagtaatt ttgatttctc tcttttttgg ttatgttttc tatgactact attattgctt
89581 taattagggt tattttaaaa tcattctcta atctagctcc ttctagatat gcatgtttaa
89641 gccttaaact cttctctacR cctttgtgtc ccaaactgca ccgctatagt gcttagctac
89701 aatcccaggt ttacaagaag tactgaactc aaaccagcaa acatgggtgg gctccactca
89761 gggtcctgac ctaaggtcat cgaacacaaa tggaggaggc agattcctta tcaagagtac
89821 aatccaagac aaactgacat aagtgctcta taaatgtgta accaggatgc aggactcaaa
89881 gggaagtccc aagccaggag gaatgcacag agccctccca aaccaagtga catcggagaa
89941 tgagaaggtt tcccctggca gagaatggga ggacaaaggg ctgtagagat aatgggaaca
90001 taaacactga tttcttaatg tacacggcat atttgggaaa aatagaagat ttgggcccga
90061 gtgtcaagta tgaggataaa atgcatgtgt tgaagaagaa atctggggaa gtcccagccc
90121 ttactgtacc tttgtgtgaa aagaaaggta cctcctttgc agagaaaagt acctccttct
90181 ctgagcagac tcaagctcag cccaggtcgt gggacgaact tagtgattgg aggatgggtt
90241 gggttttagt tgccacttgc tccatcagct ggacacactc ctgcagtgta caaactgaac
90301 aacggctcct accacaatgc tgtgaggtaa ggatacagag ctcaaagaag gtaaataatt
90361 tgcccatatt ttgagcaagg acatgcatcc agagtgaaga ctcttaagca atgaatgtgg
90421 acatgattcc atgggctgtg ggaaccattg ctggttattg aggaggaaat gaaattgaat
90481 gcactaagac tagggcacac atggagaata aacaggaagc tattgaacgc tcctggtgag
90541 acatgatgag acctgaattt ggacagtggt agtgagtaat gaaagaagtg aagaagtgtg
90601 atggatattt tgtaggtagc atgagtgaat ttgcaggtga ggtgaagtga ggagggggag
90661 aaggaagact ggcttgatat gggtcttgaa gccatcggca tttgctgata gttgaaatta
90721 tgagaattta tgagagtctc tagaaagaga aggaaagaca gatccttaga aaatgcctac
90781 atttaagagg aatcagtgaa tgaacccaaa aatagcaatc agagtgaggg aagggacaca
90841 aagaagaaag tagggtgtca tggaggccaa gagtagagtg tcaaagagga agtggtcaaa
90901 gtgtcaaatg gcaccagtgt agaacagatg agagctgaga agatttcatt agcaagtcag
90961 tcagaaggca atccattacc ttcaatgagc agttcaaacc ccaaggttcc agggggtagg
91021 tgtgtggtgg gggcggtgaa ggctggagta gagctctttt gtaagaattt gggtagagaa
91081 aggaaggaga gaggcagggc agtggtttca taggaaagtg aagaccaggg aaggctttag
91141 ttataggggc atgtgtgtct agaacatgct tagagagcga gtgatacaga catcactatc
91201 tgaagctgat agatacagac gtcagaactg agacatagaa gaaccctttg aaaggtgaga
91261 ctgcattggg agctgggagg attgagaaat caaacctaga acacaagtgg aggggctgag
91321 tttggaaaag aggcatgctt ttcttaggaa ggaggagtgg ggatgaggga ggagatgggt
91381 gaaggttctg ggaaacgttg agttgtgcaa gagaggtggt gatggtgcac cagcaagagt
91441 cccttttctc aatggttagg aaatgagagc agtggcttat agcaacggac atgatgatgc
91501 attttcacat ctgagccaaa tagaacatct gaaaagatgc tgttggaatg gaaaggaaag
91561 aagctttggg tgagtagaag ggtcaatcag aagtgtggca ggcactctga ctgcagttgg
91621 ataacttgag gttgttagat ttgtgaggag aaaagtcatc tttatcttgt tcaccattcc
91681 attcccgtga tataacacag tgcctcgccg agcagatgtt caataaatat ttgtttaatg
91741 gatgtcttct gtacttgtgc taatcagtaa aatgaggtaa atttcaccag cacatatttc
91801 gtacccaatg gagaaaacaa aattagggaa agagaagaca ggggccatca caaaggcagg
91861 gtcattttgc tgttgatgct ggttaacatc cccccttatc actttcaagt gataaaagag
91921 ggagatatgt cactctgggt tcaaagacat tttccacttc agtccttttg tcagtttcct
91981 gttctcaaac ctgtccacca agctcagtgc agtccatcat acgcacagac aatttctgtt
92041 acttggtggt gggggtgcat gaccagcacg ggctacctcg ggatgggatg aagcatgggc
92101 aggggacctc ccaccagctc agcagacctc tgaggcccat ccatagcccc agtcctggga
92161 ctgctcttca ttaggggctg cccttgggta tcctctttgc aaaataagat ttttctcttt
92221 tagttttcag ttcaccttta atttctatcc tgtaattcta tacctatcta ttctctttgg
92281 catcatcact gctcctccac tcaaccccca tttcttttct ggtctttgaa gcatgaagac 92341 ttttcccctg cctggggtct acactggctt gtggtcaaaa catttgcccc agggacccat
92401 ggcttcacca aggtagctgc tgttccctgg agctcatctt acatgaaaat gtgtgaatct
92461 catttccata aggggtattc tcacccttgt tcagttttcc tgtgctgagt tacacatttc
92521 caaaatgact tttagggcat gattctcctg attgaatttc ctgggaggcc ccactgatac
92581 tcttctagca agtgagtgat tctcccagcc ccttttctta atgccaggct ggatgtctct
92641 ccggcattct ctggactcac acctccaccc ccagccctct gcatactttt gaactccttt
92701 caggtcatca gcttttctgt tccatcttga aggctacatt ttagaatttc cgatgtgtct
92761 tagaatggaa aaaaacaatg gctgattttt ctacttgttt ttctgaaaag caatcattat
92821 atacagatta tggcacccac aaatgacagt gttcaacaca aagacatgtg taagaattcc
92881 tctgtatttg aggtcagagt gtcttgcaat tttaataagg aggctggtga cttccaggtg 92941 gtggaagctc atttattggg tcatgtcact cactctgtga gtctttttcc tctcctagtt
93001 ccatgaagca gcaggctaga gagaagcgat tcacgtagtt ggtgaagaca ttacattttt 93061 atggtgctgc tgggtatgag agtttgtgca gcttggttag aataaggtga ggccaggtgc 93121 ggtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggtgga ttatgaggtc 93181 aagagatcaa gaccatcctg gccaacatgg taaaatcctg tctctgctaa aaatacaaaa 93241 aattagccag gcatgatggt gtgtgcctgt agtcccagct acttgggagg ctgaggcagg 93301 agaattgctt gaacccggga ggcagaggct gcagtgagct gagatcacgc cactgcactc 93361 cagcctggtg acagagcgag actccgtttc aaagaaaaaa aaaaaaagaa taaggtaaat 93421 tgggccaagg aaaccacaga catgccggtt gtagtgttgt gttagtggaa actcaaaatg 93481 ttgaaagaac gtcctttgcc tgtcctcatg gtggacttaa aacccacacc tctctctgta 93541 tggtacataa atgtagactg ccagtgacta ctgtcctcct tgccacaaat aagactgaaa 93601 aggcattact gccagtggga gaggccagta tgtgacagtt catcctatct tgtgacacag 93661 agatccctgt ctgtattaat ccactcaggc tgccataaca aaataccaca gtctttgttg 93721 tgtaaataac agttcggttt ctcctgaggc ctctctcctt ggcttgcaga cagctgcctt 93781 cttgctgtgt cctcatgttg tctttcctct gtgtgttccc atccctagtg tcttgcgctc 93841 ttatgaggac acaagtccta ttgggttagg attcatccac ataagcttat tttatcttac 93901 ttacatcttg aaaggcacta tctccaaata cattcatatc catatatact gggggttagg 93961 attccaacat gtgaacttgg cggagacaca gttcagtctt cacactgccc ttagtggaat 94021 caagagtgta ggcctaagta gcagagtggc acagaggaaa aacaccagcc ccacaaccca 94081 gtggtcatgg cattgaaaac attctctccc atgactctgc cttaccttga ggacattctg 94141 ttaagtgaaa taagctggtc acaaaaagac aaataccata tgattccact tgcgtgaggt 94201 ccctagagta gtcagattca gagacaggaa atagaatggt gggtgcctgg gccagtgtgg 94261 tgtataagga atggacgtta ctgttcaatg gatgcagagt ttcagtttag gaaaatgaaa 94321 aagttttaga catggatggt ggtgatggtt gcacaacagt gtgaatgtac ttaatgctac 94381 tgagctgtac acttacaaat ggttaagagg gtcaatttta tattatgtgt attagtcctc 94441 acaaattttt gaaaaggtta cgagctgcgg aatcagacct gagttttagc tccttgtcct 94501 ccttcaacaa tatgcacaac tctttatttt tctctagtaa gcctcaggtt tttgaactgc 94561 aaaatgggaa taatgtttcc tccctgggga ctaaaggaga ttgtgaagct aagatgtttg 94621 ataaagtctt ttgtcatata actagcattt ggccaatgat aactaataat agtaacaatg 94681 atagaagaag agaaaattca gggttcaagc agatgatggc atttgctttt gagtgttttg 94741 tctcttcatg gggtcaaagt aaactggaac cttgcctggg ctcagagaac taggatcagc 94801 ctccttgtca catcaggggc ccctgggact aagactaaga gtctccggca aaacttcaag 94861 ggaggttttt cagcactctc aaaagagtat gttgcttaat catgcaggca gtaaatccaa 94921 gaacatgctg gaagagtttg acagtcccag atgacactct agctgcattc tggtctctct 94981 gcttctggct tccacagctg ctcactgggt cctctgctgg ctccaaggcc agtcctgcca 95041 ggccacagta agtgaagaac ttggcctcct gctgggacat gttgtctgcc agtacagtgg 95101 gttttgaggc cccagatctg ggcccatgga agcttcaaag tcctggctct ctccacaact 95161 tccttttccc tcttcccttg ccatggtggg ccaccttctg agccctgagc tgcctcagca 95221 tcccaggtct tggctgtgga ctgttactgc caccctgccc acagtttcta agagccagcc 95281 cagagcctga cacaattcac tcagtaagga gtttattggg atattaagaa atgcaaatgt 95341 tcttgataag aatgcaaccc agaacttcca cttgatacta gaggagtggc tttcaaacac 95401 tggtgcagag cagaattaag catctttggg tctttttcct ccttcccata tgaggttagg 95461 tcctgataga gggggtttgg tggatcctga gaggaaactg tcctggggaa ggcaaggtgg 95521 gagaaggcct ggatagctgg actgggctgg gctgttcctg agaacatatt gctgtggggt 95581 tccttcttta ttgtgggcac caccctttaa tgccatactg ctcctccagg gctccagcca 95641 tggcatgcct cctgagaagt ccaggtggac cctggtccct gccctggggt caggcgtcct 95701 tcccctaccc ccatccaYgc aggcccagct cagttttgca aaggttacag ctccagtgac 95761 tagcgaggac tgctaatggt gcaactgcct tggggacacc atgggaggat gcatttggga 95821 Rtgatccctg aatgcctccc ccatggccct gacagttcct tgcaccatgt gtggggcaac 95881 ctttataggc cctccagcct cctgagctcc ttggttcaag agcaactgag cccagcatag 95941 ttagaagaaa agcctcctcc caggcctgct gacctccatt cacaggggca cggagggtcc 96001 cttgggcttg gagtaagatg gtttctcctg cctccaagcc ttctatgagg ILIRLI genomic sequence (SEQ ID NO: 4)
>2: 102527651-102626600
1 tgcaggattt gtatgtaagt atccaacaga caacacctgg ggtgatcctg tgaatgtaga 61 ggaagacgtg atcttaaatg gaccagggaa gtaagacctt aggatgtacc agccagctga 121 gtggcaggta atattgattc tcatgtttca ccccatgttc ggtcacttgt gagcagattc 181 ttcagttcaa ttctctggct agttaaYttg gtctgggagt cacaccagaa aatgtttctg 241 aaaataggta cctattgtga aaagtataat cctctttgct attgtgagta gtgctgcaat 301 aaacatacat gtgcatgtgt ctttatagca gcatgattta tattcccttg ggtatatacc 361 cagtaatggg atggctgggt caaatgatat ttctggttct agatccctga ggggagcggg 421 gagggatagc attaggagat atacctaatg taaatgacga gttactgggt gcagcacacc 481 aacgtggcac atgtatacat atgtaacaaa cctccacgtt atgcacatgt accctagaac 541 ttaaagtata ataaaaaata tatataaagt ataatcatca aattgttaaa atcatgattc 601 tcatgaagta gattgtgtct gttgaagttt aattaatgaa ggaaacaaca ggatgtcagg 661 actgaatcca taaggatctg agaaactggt atttccataa gatgttaaga taatattgat 721 aactgggata caaaactgct taatgtccta caatgtaata aaacaatttc tgttgtgttt 781 tgcatgagat agaaacaaaa atacctccca ttggtcagtt ttctacaaga taatctttaa 841 ctttacaggg ttgtaaaata gctatgcctg aattgttagt taaaacccca tttttttttt 901 tagagaaaac aatgatcctt agactcactt actagaaata tgttctagtt tttttataaa 961 aataaaataa aataaatatt tttattataa aataataaat atttttataa taaaaataaa 1021 aataaaataa aaaatattta ttttaaatat ttttttcaag catcagtata ccttattctt 1081 gttcaacttg gggaatggcc ttattcaaat tgggaatcct cagctcatct ttgtctttgg 1141 cattccagag aatgaatgtg tttgggaaat tgtgtcagct gagcagtgta tacagaaagg 1201 gacaggagac cactgaaatg gttcaggtta tagttagata gttcctgcca ctggttagat 1261 caggagagtt agatggttat agttagatag ttctttatgc tggcagtggg aaacaagaga 1321 agaggacata tgagggagat gctcatgtta ttgggaacaa tatttggctc ctggtagaat 1381 gttaggggcg agggagaaga ttctaatgtg ttgagttcgg gagccgctgc gccattaata 1441 aaaccagaaa ccttctacag tgctccaggt gggagccatt agcatcaaag gcgattctaa 1501 aatcagtcct gaaagctatt ctatcccttg ttctgcatgc agaacagctc ctgagggcct 1561 gttgagggcc cagggaaact ttggcccagg gccaaggaag gactggtgtt cccttttggt 1621 ttagctctgc tcacagacaa ctgcccagaa ggtccaggtt ccaagtcact gtgcaagctg 1681 acacgtgtga gacataggaa gctgttggga ctacagaacc cagggactcc aaaccctgtt 1741 taagtaccac acctgagggg aagaagaccc tgcttcccaa ttagtcagct gggtagaagg 1801 ctgaggattt ttgaaaagag gtagttggtt tagcctcagc tttctttaga ataatattgt 1861 ggtttgaaag tgtgcaacct cctagtgtca tcatttcctt ttgtccctga cagaactgtc 1921 ttcacgctgg aaataaaagt atgggacagg cttgaagcag agttgtgaag tagaagtttg 1981 ctaggaatcc attttttatc gaaagcccca ggcaactctg attaatttgg tctgggagtc
2041 atacatggag aaatactgtt ctaggagctc attcagctaa cacctctctc acctagaggt 2101 catgcgggga aagaaatgtg tattgcatta taattcatag tagactgtga ataactaata 2161 ggaaaagatt cctttcagct tctcctgtct agttaagttc cagcagggac acacctttag 2221 cttaaaggaa tgcattttag tggtgatggt ggtggtggtg gtggtgatgg tggtggtggt 2281 ggtggtggtg gtgtgtcttc ctaggtcctc tcaaatcaca tcacatggtg gagggataaa 2341 aagaggcagg taaaaaatag catttgttct acaattgatg aatgactaaa tgtcctcttg 2401 aacataaaga atttatattg gtaaaagctt ctctgctatg tgcattagta aaaacaacaa 2461 catcgtgccg ggcgcggtgg ctcacgcctg taattccagc gctttgggag gccaaggcgg 2521 gtggatcaca aggtcaggag atcgagacca tcctggctaa cacggtgaaa tcccgtctct 2581 actaaaaata caaaaaatta gccagcgtgc tggcaggtgc ctgtagtccc agctactcgg
2641 gaggctgagg caggagaatg gtgtaagtga acccgggagg cggagcctgc agtgagccga 2701 gatcaggcca ctgcaatcca gcctggggga cagagcaaga ctctgtctca aaaaaaaaaa 2761 tcgtttgctg atttagaact cttcttaaag agcctccata tgtttaaaga gccatgcctt 2821 atgactgtat gactataatt ttataaagcg ctttccctac agtatcttac taaatccttt 2881 cagcaatcct ggaagtacca tcattatctt tattttgcat attcaagttc tgaaagcctg 2941 gtttgctcca gtaagtagta gagctaggac caaaacccaa gttttggttg ggttttcagc 3001 cctgaatctt tcagccctga accttttcat agctgcctct gacttcacag ctcactgcat
3061 aaagccttct tcagacccat cctctgtcag catcgtctag tctagcctgt caggtatttt 3121 ggcctccaca ggagatccta ttctcaatgt ttgtaaatat ttagctaaat ctgtagcaga 3181 catctggttt cataatgaga aagagcattt ttgttttcat tagggaaaaa gagcatgact 3241 gggcgcagta actgcagttt tcatcgtgga gaaaaagaga gtgagacttg aacttgaaaa 3301 agtgaagcca agcagtgcag ttggcaggtg gagggtgggg aggagggaga ataaagacaa 3361 gtcaggagga gagagaggaa aatgatgcac agagaaagag ggaagaggca aagagaaagg 3421 aagggagcct ggacagcaga ggggtctcct tcaggaaaca gagttgaagt gaaatagtgt 3481 aatccccagg tggcaggtac aacatttctc agcacaatga ctctgaacaa cttaattctt 3541 tcttagggga agtagttaca cggaaagtgt aatgtgtgct gcacatttgt agttgtgata 3601 ccatcagaaa gaggtacttg ctgtggaaag aacttctcaa cccctccatg taatgaccct 3661 tggagaatgc attatcaaag cagagtcctg cagcctgaaa gtaaacagca tctacttaga
3721 aatacagtga catgtaaact ttccccaaat caacagtgaa accagtagca ataactttga
3781 tgaaacaaag gggcattgcc gagctgtcag gacacaacag agcacaacag aacagcccca
3841 ggtaaatatt gataaattag gttgatctgt gtattcttag tcatgggaag ctggggcaga
3901 taacgaaacc ttgtatgtgt cctttatagc tctgtctgat gagtttgggc gacggagtct
3961 tgctctgtcg cccaggctgg agtgcaatgg cgtgatctca gctcactgca acctctgcct
4021 ccctgattca agtgattctc ctgcctcagc ctcctgagta gctgggatta caggcacgtg
4081 ccgccacgcc aggctaattt ttgtattttt agtagagaca gggtttcacc atgttgatca
4141 ggctggtctc gaactcctaa actcatgatc cgcccacctc agcctcctga agtgctggga
4201 ttacaagcct gagccaccgt gcccagcctt gttttttttt aagtgatttt tgagggcagt
4261 tttatgggca gaaaagactc ttcgtgaatt tattttgatt ttaaaattac tattcaattt
4321 ttcaaagtta aaaatgtaaa aaatctagtt tattataaat tgaagaccag cttaaaaatc
4381 atataatacc atttatatgt ctagcacatt ttaacaaact tcaacactag gttactccac
4441 ttacaaattt ggcaaactaa atattttaag gtattttaaa ccgcatttat acatttactg
4501 tatttgattt ttcttcttaa gaactttggc taaaaccttc ccaagtaatg aattaattct
4561 tataaattta agttctctta gaaattttga cgctacatat aagcttaaat attggatata
4621 aacttagtaa ggatttcact taaaatcgta aatctaaaca atttccaatt ataccttttt
4681 aaaaaagagt tacatgactt attctaatgg gtcaatattt taggcatcac aaatacataa
4741 ttgcaaatat atagattcct taaattatac catggtcttg attcttatta catagatgtg
4801 tacatacctt tctacccagg tctaaatacc actgaattca aaatgagtct tgcattctaa
4861 gtacttcgaa attcttaatg ggtattaaaa agtgacccag ttgcttatgg ataaacctca
4921 taatttgcct tgatacttgg tcacaaatta aaggtcattc tactgacaaa ttacttgtat
4981 acaatctaca aaacaaatag catgcaattc tcattacagc acacgtgttc agactttaac
5041 aaagctgttt gaagtctaca tcatctcctg agttagagaa gccccaattg ccacatacag
5101 atacttagta ctgtcataca gagtcacata tctactggat tctacctgga tcttaggatc
5161 aagatgcttg tactcagaca aacaaattag gaaagtagcc tcctttgcag agtggtctag
5221 gggtgttacg agccaaaaaa tcattcacgg ttttatggtt aagaagtgag atgatctgta
5281 atgaaacctc acagagattc tgttaaataa caagtgccca aaagctactt ggaaaaggag
5341 tagactgaag agaaaatgag agaatcaaaa atagttttaa tttcctgtta gaatcatctc
5401 ctttacttta ctcttgcatg tgtaactgtg gaggagattg taaacattcc cttagctaac
5461 tgtacttgtt actcttgatc aacatccctt agtaactgtg tatatgtgat gcttcatgca
5521 ttagtcagag ttgagaacaa aaacagagta gctcaaacaa aacataggtt tatctgtccc
5581 tcatgtaaca acacatgggt agccaggtgc tctagggatg gtagatggat ctgcttcatg
5641 aagtcactca gaatccccaa ttcctcctac cttgctgctc tgccctgtgt ggtcctcatc
5701 tgtctcaccg ctgaagccac cttgcagttc acctagaaga gaatatgtac tgtttctgcc
5761 aaatctgtgc tatagatact agatgctttt aatggagagg ttagccaaga aacatgacat
5821 ttctcttata ggtaataaaa tacttctctc taaagaaata cttagtttaa aattttattc
5881 tgctatagtt ttagcagtag gataaaagct tagtttgcag aagcggaaat tatcctatat
5941 ttaggcaaag tgagctatct gtgtgttatg attagagaga ataccaagaa gtgatttcct
6001 tccttaaaat aacttctcYa aatttccacc attaactacc cattcttcaa ctctctcaat
6061 ttttcttatt cctcccatgg agggagtgca tgtatttaat tactaacttt actagtatta
6121 tataatctat gctccaaaat ggttagtcta caattagtag agggataagt ctttagggtt
6181 ggaaagaaaa aacagttatt aaagatctac tattgctgga tgtcatacta actcttctta
6241 cttattatgt tatttatacc acctaacagt ttgataatat tacccatccc cccgcttttt
6301 tttttaagag ataaggcata tatgacttat atagagttta ggggattttc ctcaagatta
6361 gacagttaga agtctcttgg gtgggagagc agttctaggg gaaaaggaaa gatMagaaag
6421 acaagtcaac tactttgagt aaagacctct ggctgagcag gtcattgtgt attcccagaa
6481 tttgtcacca actagttgtg tggttttgga catacccctt cacatcacct caatgtcacc
6541 tttggtaaag tgaaagaatt ggttgtagat attctttaaa ttatctttta ttcaggcttt
6601 ctacagccca attctctcaa ttgttgactt ttacttagaa ttttgggcaa acactagctg
6661 atacaatcca tttaccaaga tgtttatctg atgacatttt catcaagttt ctaaagatgc
6721 catattgtct ttctggcagg cttttggaaa gtgttcaaga tctcctgttt tattttcaca
6781 gttggcccct gagcctcaag tgtaagcaga gctgggctga gaggcttagg tcctcctggc
6841 tgatgtcact aggctgaggg gccttgggga agaaaacaaa tttctcccag attcaaccct
6901 ccaaccaact gcaggtcctg gaacagtgag taactccttt actcagaagc tgaacattaa
6961 aagtcttttc tgattcttac caacttggca cataagaaat acagtcattt cctcaaatac
7021 atttttatta tgagggtact gaacattgta tttattggtc atttgcattt tttgtaaatt
7081 gtagattttt aaaaacctct ttgtctgggt gcggtggctc acacctgtaa tcccagcact
7141 ttgggaggcc gaggaaggtg gatcatctga ggtcaggagt ttgagaccag cctgaccaac
7201 atggtgaaac cccatctcta ctaaaaatac aaaaattagc tgggcttggt ggcgtgcgcc
7261 tgtaatccca gttactccgg aggctgaggc aggagaatag cttgaaacca agaggtggag
7321 gttgcagtga gccaagatcg Ygccactgca ctagcctggg caacaagagg gaaactccat
7381 ctcaaaaaac aaaaacaaac aaacaaacaa aaacattttt gtattaacta gtaaagtctc
7441 ctgatacatt aagaatatta aagacaggca tatagtgagg tttttttgtt tagtttccat
7501 atgcctttta atttgtttaa ggatatagtc atttgtttag actataggta aggaatagtt 7561 atatcttttg ttccagaaag tttcagattt tgagggaata ttactattcc taaggtttta
7621 ttgacatata aattttaaaa atattatgta atgagagcta tatatatata ttcttttttt
7681 gtgcatttta tcatgggtac taggttaagt gtctgtttct atgaacatac aacttactta
7741 acatatgact tggaaacaga acatgcatag taaatgtttc tcaagtaaat aagtaaaagt
7801 atatgagaaa caaatgtgct gtttacatgt tgtcatagga atcatcttag cactaaatgg
7861 ataattagga tccaggttca tccttgggct tggcacaaat gagcttggac aatctgaaat
7921 atggatggtt gataataggt aattaggttt aaattatacc aggaaactga agaacattca
7981 gaaaatggtt acagataatt acagaaggtt gcattacaga ggaaaaattt ctcacagtga
8041 gagacaattg gcctcacatg cctttactga ggcatacatt gtgtcataat ttccttttat
8101 tgcaccttca acattttgaa gggaattaat tgtctgaatt aggctagatg tcattttttt
8161 cttggaatta gaagaaagat tgagtaaccc cttatgttta tctggaacat gtctttctgt
8221 gcatttaaaa atctcagagc ccttcagaac cttgcccgtg acccgtcatt gggaatatct
8281 taaaaatgtg tgtgtgtggg tgggtgtgtg tgtgtgaata taggaatgag ggaacactgt
8341 cgtagacaga tatatctgaa gcttatcttt tggtttaggg catttggtct tgcatcacct
8401 tttaagtctt atgctatcct tgacttttga acagaacaaa cttctagatt tttgtatgtt
8461 ctaagttctg cctttgcagt attagaggtc tattttccca gactagggac tggagtgttt
8521 aatcatcact gtcatgtaga cctaatatag aaatacaaat gcaataagaa aaatgttgag
8581 aaattaaagt cagaaacata tttgttgtga tacatgttca aaaataatat atttcattgc
8641 aggaaatagc aaatccagag aaataaaaag aaagaaaaaa aataatctgc atttctacgc
8701 atgcagctaa ccattgctga gattttggag tccttgtttc ctaggcacgt tttcctatgt
8761 ctgtgtgcac acatgtatgg gatgttgcat atgtgtatgt gtgcatgtgt ttacacatgt
8821 atttgcaggt atgtgttgat tattatacat tgagtcataa tgtatattac atttaaaatt
8881 tcctgttttt acggctttat taaggtataa ttgagatatg aaaaattgca tacacttaaa
8941 ttgtacagtc taagttttgt catatgtata cacaccagtg aaacccttac cacaatcaag
9001 ataatgaaca tacccatccc ccgtaaagct tctacacccc tttcgaagtc catccttcaa
9061 cttctcctac cgaatccaca ggcatccact gacctgattt ctgttactat aagtttgttc
9121 acattttcta gaaattgata taaatggaat aatacagcat gtgcttgttt ctctctggct
9181 tcttctattc tgcgtaatta ttgtgaaagt catccatatg attgcattta tcagtacatt
9241 catactattg catttatcaa tatgtcattc ttgttgattg tttatcatat tcccctatta
9301 tcttcttaac atctatagaa acttagtggt gtcaactctc tttttcttga tattagtaat
9361 ttgtgtcttc tttctttttt cctcagtcag tgtgactaga gagttatcaa ctttattagt
9421 cttctcaaca aaccagcttt tggcatcatt gatttttctt tattgttttt ctgttccatc
9481 tcactgtttt ctgcattgat ttgtattatt tcattttctt ctgttttctg tgctttcttt
9541 gctcttcttt ttctagtttt ttaaggtggt aaccaatatt gatttatgac ttttattatt
9601 ttctaatgta tgcctttagt gttgtaaatt tccctcttta gtggcatatc ccaaattttg
9661 atatgtagtg tttttgtttc catttagttc acaatacttt ctaactgccc ttttgatttt
9721 ttgtttgcac catgggttat ttaaaagtgt attatttagt ttttgcacat ttacaaagtt
9781 tctatatatt tcttttattg attttgtgat ttaattccac tgttgtcaaa taacacactt
9841 tgtatgcctt gatccattta acttattgag acttggtttt gggactggaa tatgctctct
9901 catggtaaat gatccttgta tgcttaagaa gagtgcttat tccagtgctg tcaggtggag
9961 agttctataa ataacaatta ggtctacttg cttaacaatg gttttcaaat tttctatatc
10021 tttacagatt tttctgtttc ttctatcaat tactgaaaga agaatattga catctctgac
10081 tgtaactcaa gatttgtcta tttctccttt catttttatc agttttttcc tcatgtattt
10141 tgaagctcaa ttattagaag cataaacagt attgttatat tcttcagata aattgacccc
10201 tttatcatta tggaataact ccctttattc ctggttatat ataatatatg gaataactct
10261 ctttattcct ggttatacat aatatatgga ataactccct ttattcctgg ttatatataa
10321 tatatagaat aactctcttt attcctggtt atgtataatt ttagagcaat atataatatg
10381 catatttttt gtctaatctt attatagcca ctccagccac gttttgattg gcattaatat
10441 ggaatatctt ttttctttct tttgctttga aacttgttgt gtctttgtat ttaaagttgg
10501 attcttgttg gcaaaatgtt gttgggtttt cctttttaaa tccaatctga gaatctctag
10561 cttttagttg gggtgtttgg agatcattta tgttaatgtg attgatagtt tgggcttaaa
10621 attcttctct tgctatttgt tttctatttg tcccatctgt tctttgttcc tcatttatcc
10681 tttttgtgtc ttattttgga ttacttgttt ttttttataa ttccaaattt tctccattgt
10741 aagatcgttc tctatagctc tttgttgtga tattgtagtg gtttctctag ggttatctgg
10801 agttagtata catctttaaa taacacagtc caccttcaag tgatattgta ccaattcact
10861 gataatttaa gagctttaca acagtgaact tccatttctc ttctctggtc tttgtgctgt
10921 tgctgtcata catgttgctt ctacacccct attataaaac ccacattata ttgtcattac
10981 tttYgcttcg aacaatcaat tatcttttaa ataatttaaa caataagaaa taaaagtctt
11041 tttatttacc ccatagatgc catttctggt gctctgcatc ccttcctgtg gatcagatct
11101 ctgtctggta tcagttcttt ctacttggag gacgttcctt tcacatgtct tgtagtactt
11161 gtctgttact gacaaattgc ttcagctgtt gtatgcctga aaaagttttt atttcgtctt
11221 cacttttgaa caatattttt attaagtaaa aaattctaag gtgacttttt ctttcagtca
11281 tttaaagatt ttattctgct tgcattgttt ctgatgagaa atctgatgtc accctctccc
11341 tagttcctct atagtaacat ggttttttct tttctcactt ttaagagttt ttctttatca
11401 ctatttttag tgtttgagtt tctgggtact tcagggtttt atacttttca tcaaatttgc 11461 aatattttgg cgttatttct tcacataact ttttttctgt ccttttgttc actcctttcc
11521 tcctggaact tcaattatac ttacattaga tgactcgaaa tttccccaca attcacagat
11581 gctgtatttt tttcagatct gttttctttc tgtattttat tttgcgtagt ttctattcca
11641 tacaatatat ttttcatctg aaatgtagct tttatctgta gatgttttat ttaggtcttt
11701 ttaaaatctg ccatatctct gcttaacaca atatttcata taggtttttt tttcacatat
11761 ggaatttgga tataatagct gttttcatgt ccttttctac ttattctatt tatctatgtt
11821 aattctttgc tagttttgat tgattgattc ttctctttat taagggtagt attttctgct
11881 cctttttatg cttgaaaatt ttttattgta tgccagacaa tgttaatttt aacatattga
11941 gtgctgaata tttttctatt tctataaata tttgagctgt gctctgaatt actgttatgt
12001 tgccctgaaa caagtttgac atttttgggt cttcctttta agtttttttt atgtgtaacc
12061 agagtgacat ttagcctgtg gttaatttat actactattg agacaaaact catgagttat
12121 gtcattttcc attttgaata gtgggcacag gtactatttc tgaccctgta agagttgtgg
12181 taattgttcc ctctgatcgt tttgggtggt tctttctttg accacagatc acttcctcag
12241 aagcatgaac tcgtcagtac tgagctgagt aactgaagag ggcgctgcag atatctctgt
12301 agtgatctcc tcagtactct gtgaactcaa gtcaccttag cctttccaga Stcccagctc
12361 tgattcctca tctcggagag accactggac ttcatctctc ttcctcttct ctttgccaga
12421 gttcagaaac tctccaggca gtaaccaggg caattgccag cctctttttt tgcttcccat
12481 ctctcaaggt tcaccgtcgt ccactgcctg atgcttatat cttgaaagct gttgattcat
12541 acgttttgtt cagtgtttag ttatttaagt caggagggta aatcttattc ctattactct
12601 atcttggctg gaagtagaaa tcacaaaact tgcctctaaa caaagtatat cacaaacatt
12661 ttctatttat ttaaatatta ttagtctaca tcattttgga tgactacaaa gtattttatt
12721 atttaaaaat accatatatt aattaatact ttatttttta tatttcgttt tttcctgcta
12781 ttgttacaat gttgtgaatg agcagataaa tatttttgaa tatccatgat tatctcaact
12841 gtattagtag aagagaaatt gctgagttaa ggggtatttt gatgcagatt tccaaattat
12901 cgtctaaaaa ggttgcaccg atttatatac ttattatctc tccaaatatc tgggtattat
12961 tattataatt tttttaaacc tccaagcttc ataagtaaaa atggcacatt tattggtttt
13021 aattagcatt tttatttctt ttgatgtata atattttaat tagtttattg aaaatctctg
13081 tccttccttt ttgaatttag tttatatctt ttgcatattt taaagtttag attgttgtct
13141 tttctgttat taatttataa aatatttgtg ttgagtgtgt gagtgcatgt gcatgcatgt
13201 gtatgcgtat gtgtgtgttt gtaacatttt catcagtttt ttgcttgccc tctatttatg
13261 gtattttcag atgtgattag atttatttgg tctttgacat tatgatttct gtctctatca
13321 ttgagtttag aaggYcaata ttattcctac ctcattacca aagaaatact taattctatc
13381 tgcttacaga tttaactttt ttctttttcc ttttaaatct ctaatacatt tggaatttaa
13441 ttttcttact gattaaactt tacttgtata tgtttatatt ttataatgat aatattaaac
13501 catttgtaat gcttaaatta aatattaaat ggtcataaca ccatttattt aaagcctatt
13561 ctttctttca ggtttgatat actgactttt tcatcatgtt gataatcttg tgatatattc
13621 ctgttaatgc tccattggtt tctacatttt ttatcctgtt cttataagtt gtctgtctcc
13681 tcctgtggct gttctatttt attttaatta ctgaaacttt attggacaat agtaagctca
13741 gaagagaata tctgtaggac aacagtaggc tcaaggagaa atcatctgtt ctcctaatct
13801 tttactattt ttcgtatttt cctgactgat cttcagtatt tctggaaaat tgacaagcaa
13861 tgcagatttt ggataatagt gcaggcttca ctttcattgt gcctgggttc aaatcccagc 13921 ttcttagctg actggcaatg tgacccagca aatttattta ctttggcatg gctcagtttt 13981 cttatctgta aagtaagggt aatagtagtc cctatattat aagtttatta tgatgattgt 14041 gtgggtggaa cccgtgtgtg gcacacaccg gcacttagtg agaagttagc tttgccattt 14101 tcctttattc ttcactttaa ttttagaatt attttgtcaa cttcaaaaaa gttcattatg 14161 aatcttatta ctgagtcttc tctagaagca tgacatgact cttcattcac ttgttttctt 14221 ttgcgtctct cgggaagttt tgcattttct gttgtgtata tataatattt gtacattata 14281 tctaactatc tatctatcta tctatctatc tatctatcta tagatatata tatatacttg 14341 cacaattata tccacataca ctctaagaaa taaggccagc agaaaatatg tgggtatgtt 14401 agactataat tatctctgag tattaggtta tgagaatttt ttcatttgta gtattctata 14461 cattttaaaa cttattaact gagcattact gatataaatc aataattttt aagtgacttt 14521 tgtgccctac tacgctggtg ctgtgtgctt cagactgaag ggcagtgcct gttagatctt 14581 atgtgctaca tgttacacaa gtactttggg aaataagctg ttgttttaaa aaatgtgtca 14641 tcaatttcta gagaactgga cataactttg aagcaaaaca attttaagtg gatgactaaa 14701 atccttcctg aaaacgcatg cctgtggtcc ctgtgaaatc accttttctc cccctttcct 14761 aatctccttt ccctcctaaa tctaaatttt cttgtaatgc ttcaaaatat ctggacttga 14821 tctcagaaga tattctgtca tgcatattga caggactggg tactttcagc aaaacaaagg 14881 acatctttaa atttttacca gccccagata gaagtgtcta gagttctaga ttttaggaga
14941 aatacagcca tgaaggaaaa tgttgacatt tatttcaacg tttcaacagg aggaaagaat 15001 gagaacacaa tgtacagatc agcctttcct ctcatgttct tacaatggga gaaggagaga 15061 gggtatttga gacaccaaag catgaaagcc atgacacagg gaaaatactg agaacataac 15121 ctacagatca gattttcctt ttatgctctt accatgtcat aaggcaaagt gcttgtttga 15181 gatttcaggg cacaagagcc actacagcag gaaggcgtcg catcatcgga acatttgtga 15241 tcaaagagaa gactgtctgc acaaagcacg gactgcagcc aaggggtcct tcacccactg 15301 ttctcacaaa tgcttgcctt tgctatcaca actgctattg ccagctggac gctgagtgtc 15361 ccσtcagggt tcatagagat ctgtctccct gaggtctctt aggtgctgct gctgaccagt
15421 agtaacttgg tgaagaccct cgattgtgag gacattgtgg tgaaatgttg ctttcttgac
15481 aaaacaaatg tgtttccttc tgatccatga acaaagatct gttgaataaa tattatgagc
15541 gtgtagaagg gagagacttt atctgatcag actagggaaa gggtgctttt aatatctgtg
15601 gaacaatctg taagatcgga cgtttcctct gataacagaa actccagagt tacaagagaa
15661 atggcttcct gacatcacag acactaaaag gccttctgag taggagtagc agttgaattt
15721 ttgactacta tgtaagggaa atacagtacc aaaaaaaaaa aaaacccatg gagatcaagt
15781 catttcttac tagcaagtac ccctgacttc tacgtatttg ttgttagatc cacaaagaat
15841 atagtataac ttcattttct atcaactatt agggatctat agtgccataa caaagtactc
15901 taaaatttat cagcttaaac agtaaacctt tattatctca catggttcct gagggtcagg
15961 aatctgacag tgacctagct tggtgattct gcctcggggg tgctcatgaa gttgtggtca
16021 agσtgttgac tacacttttt catctcggaa gacttgactg caactgaggg acttgctgct
16081 agggtcactc atgtggctgt tggcaggagg cttcaggacc tgtctgtgtg gagcactctc
16141 tggggctgcc ctcgagatgg cttctctcag agggggtgat tcaagagaca gagtcccaga
16201 caagtacagg atgccttaca taacctaatc ttggaaatgg cacgtgatca cttattccat
16261 attatattga tgacatagac ctgacctggt acagtgaggg aaaagactac acaaggatat
16321 aaacaccagg atgcagagat cagggggcca tcttggaggc tgcctgccac agctattaaa
16381 ggtaatttgt tgacaactca caatttctag ctacccagtt gctcattctt ttgcttaaac
16441 tattcaaggc tggtggggga catgtgaatc ctgttaaaat gtggaaagat ctaaatgtgt
16501 tttatagaaa aaattgagta aacttttttt gcttaataag caaaagaatg atgaggaagg
16561 aaggggcaat tgtgtgtgtg tgtNagagag agagagagag agagaatata aaaatctaat
16621 tttttaccaa aattattttt tttcttccgg gtgaacatgt ggctttaaca taacttctat
16681 tccacaaact caaaatcaag cacctctgtt aactcttaac taaacataga ctttttStga
16741 actttggaat aggagtaagg gggaagagtg aaacacacta gctttcatgc cttgtttaat
16801 ttctaatttc ttaaagagtg gacaagaaag agaatgaatt cagcaaagtc tttgatccct
16861 acagttcata ttcagacaaa taggagccaa ttattaaggc taactgcctc agtaaaataa
16921 aaaacagcca atttaacttc tgaacacagg aaggtttttt acccattatg gaatcatgaa
16981 agatctgaat gcacatgata tggtgtaacc ataaaataag gttgagtttt tgcttcctgt
17041 taaatctcat gagaacaagc attctgagtg aggggtgcgg taaagacaca cagggctagt
17101 cttaaaagaa ggtaaagttt ctggctatgt attaggcttg attagaattt tctggttaaa
17161 acgaattctc cttcagtttt gtttctttca tagatgctgg aattcctata aaagccattc
17221 agacatttat atttatgact tttctacttt ttaaaaaact atactcctcg agagaataaa
17281 ggagtaggtt ttactagaca ccatatttaa tgggttaaag caaccaagta agaagaggga
17341 atgttctaga agtgagggaa aggggattca tgcagacatg aaagtgaagc aaaggtaaat
17401 gtgacagaga aaaatgaatt tgccatctct ttctttcttt ctctctttct tccttccttc
17461 cttccttcct tcctccctcc ctccctccct ccctccccct Gtctctctct ctctctcttt
17521 ctttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
17581 ctctctttct ttctctcttc tttccttctt tctttttttt agccacagtt tcgctgttgt
17641 cgcccaggct ggagtgcaat ggcaggatct tggctcactg cgacctctgc ctcccaggtt
17701 caagtgattc ttctgcctca gtctcctgag tagctgggat aacaggcatc tgccaccacg
17761 cccggctcat ttttgtattt ttagtaaaga cgggatttca ccatcttggt caggctggtc
17821 ttgaactcct gacctcaggt tatccaccca cctcggcctc ccaaagtgct ggcattgcag
17881 gcatgagcca ccatgcctgg actatctgcc ttctttctaa aagagataaa gctttctagc
17941 tgcctagtac cttggtgaat ttgggctgag gccattcagc gacaagcact ggaaagaatt
18001 gaagtgctcc caagtacctc tgcaagggaa gaggggtgat gagcagggga gaggagagga
18061 ggaagaggac ctggtggatg gtaggaggcc atcaggtctt ccatgtgatg tgcgaatctt
18121 tagctaggta caccgtattt tagaaatgtt tggtgtaaat ggatttcttt tgcaaactgg
18181 agaggggact gagttttggg ctgatgctga gtggaacaga gatgggactc ctggagcttg
18241 agacacagga tcttggagaa aatgagcccc agaaatcagc agatgtcatg aggggactct
18301 gggttatcat aagctgtgga attggtatcg gatctgaact tgtttcttca aagtgcaagg
18361 aagaccagct aatctcttgg ttttgccaat ttagggcaat tttcaacatt acgaaaattc
18421 atttagtttg ggtgcagagc tcagatgtcc tctccatgtg gacacaaccc tacatgtgca
18481 cacacaaaca agcacttgag cacacatgtg tgtgcacaaa ccccactttt ctgcttttcc
18541 aggagcaccg tatgttattt cagacaaata agtttggcca actttgatct ttccattcag
18601 gtcactgatt gctgaattgc cacagatgtt gttctgccct ccttaggttc tagggcattt
18661 tcattaagga gagttacctc caagaggggt catggcaggc gagcaaacca tacttggggt
18721 gcaccattaa agacctccac ccctggggag cgatcctcac agcggagcag gacttggccc
18781 cttacaagtt tgcctagtct ctccctgaca ggtgggtaca gcagcaggag tctgaattcc
18841 acattttgca gagccctggc atagacggat cattcaagag aaacttcctt aagctgccca
18901 cggctgctca ggtcctcatg tctgcattca gatgtggcct tctttattac taactcagga
18961 ggaccttgat ggatgttagt ctccctggat ttgaaaacta tttatgggag cactgaaaat
19021 ggcattattc gttttgatgg caatcaagta cataaatgcc aatgatagag actgaaggat
19081 aagttccaca gcggatgtgg ttcaagtttc taaatactgc tgccatgatt ctcatgtgat
19141 gtgaaggata ttaagagatc tagaactagg atagaactgt agctcaacca tgctagaaaa
19201 aaattttttt aagttccact ctatttaaaa atatttgtgt agagacaaaa tctcactgtg 19261 ttgcccaggc tggtctcaaa ctcctggcct caagtgatcc tcctgctttg gcctcccaaa
19321 gtgccagaag ccactgtgcc aggccaaaaa gttatactcc tgagtaaaga ctactttata
19381 gtctcttgat aacctaccat aatttaaaga atattctgat tgctgtaaat ttctgtataa
19441 tttaaatctt aaggccgggg gcagtggctc atgcctgtaa tcctggcatt ttggggagcc
19501 aaggagggag gatcttctga ggtcaggagt tcgagaccag cctgaccaaa atggagaaac
19561 tccatctcta ctaaaaatac aaaattagct ggatgtggtg gcaggtgcct gtaatcccag
19621 ctactaagga ggctgaggca ggagaatcac ttgaacccgg gaggtggagg ttgtggtgag
19681 ctgagattgt gccattgcac tccagcctgg gcaacaagag tgaaactcca tctcaaaaaa
19741 aaaaccaaaa aatcttaaat ttgcagattt gtaaaatcct acatccctgt ccccacctct
19801 cttttcccat gatctttagt ttagttcctc aaggtcagga atgagtctca tcttctcttg
19861 cacctctcac agtgcctgac acaatattgg ggacattgat aagtattgtt ttgtgtatta
19921 cttaggcata ttttctgtgg ttctctagca gtggagaata aatgattgat gatcttatga
19981 agtcatagtc cacctaaaga ctgcgtagta cgcaaatgag tctaccatta tctcctcgat
20041 gtagattttc atcttttatg tatggtgact ctaggtaagg agaagaggtg atctagctca
20101 cttggtggga cgagcgtctt gacacaaatc cacaaaaaaa ggagagtaca cacagctgtt
20161 catttgtctg tgtgttgagg tgggggtggg ggaggtgagg ttgtattcac acagagaaga
20221 catcttagct ctgcacccaa accaaaacga gcgtcagtga tgttaaagat tgaaggtcag
20281 gtgctaccca ggttttgtta gtctcttgac ataaacatgg tgtctagata tggtacatat
20341 tatgaatcat tccatctttt caaatacatt ttgaagggtt tttttgtttg tttgtttgtt
20401 tttgagacag agtttcgctg tgtcaccaag gctggagcac cgtggtgcag tcttggctca
20461 ctgcaacctt tgactcccgg gttcaagcaa ttctcgtgcc tcagcctcct gagtagcttg
20521 gattagaggt gtgcaccatc acacgcagca aatttttgta ttttagtaga gacggggttt
20581 caccatgttg gccaggatgt tgggattaca ggcgtgagct accatgccct gccagaaggt
20641 ttgtttttat tttaaacaca attgtgctgg gtgtgatagg atgggtatat gatagagcag
20701 aaaatcacta gtatttcatc aatatggata gcatcctcca taggttactg atttaatatt
20761 gacaacaata cccttcacac gagagagagg ttagagaatt tgcccaaagt caagcagctg
20821 ggaagaggaa aactaggctg tgctctccct aaatctcatg ctctattata ttagggaaga
20881 ctctggcaga tggcacatcc tgattatttg aaagtcacca atatttttag aaattgcata
20941 gataattaag gttagtttat ccagaattct aataattgca gcacatgtcc ataaatctct
21001 attacaacca cctgagatag gccatctcgg gcatgtggaa aaagcccagg tatagacact
21061 ttggatcctg gatttccctt gtactggctg ctaccttggg taaggtaatt ctcctctctg
21121 aagctcctgt cagcttctga ggattgcgtg ggatagcaca taccaaatta ctgcacacag
21181 agcctggtgt acacttaagc acacgagatg tgtcaaagtt ttcaaaaaca ttgccaacga
21241 ggcatcagtt acaaaacttg ctgcagagtg agctgatatt gtgccactgc actccagcct
21301 gggtgacaca gtgaggcttt gcctcaaaaa aaaaaaaaaa aaaaaaagaa agaaacacca
21361 aataagcaac ttgctgcaga aatgggtact cttgttctag aaatgtgact atagggaagt
21421 tacaactacc aactcgcgtt aagggaaatg agtgacctgc cacctacatg gtgttaggga
21481 ggttttgctg agaaagtcac tcatgaagaa ggcaaaatat agttaagaca aaatgtaact
21541 atctatagag ataaggtaaa aattggaaat agaacttcat taaagatctt tcaaataggg
21601 agaatgtggt gaaaactgca gttaacattt gttaacagtg tgatcatcgg gttcagctta
21661 tcagtaacct ggttcctgtc tcttaactga taaagaaaat gggaggtttt taaagagagg
21721 ctggctgttg tatttagtaa agctataaag ctgtaagaga aattggcttt ctgagttgtg
21781 aaactgtggg cagaaagttg aggaagaaag aactcaagta caacccaatg agggtaagtg
21841 gctttggggt atttttcaaa aatactttta tctcaaaggg aacaaaattt tcacatacga
21901 atttaggtca ttataacaat aatattcatt gttatattat tataacatta tatgttataa
21961 taatatataa tatatataat atataattgt tataacatta taacaattat atattatata
22021 taatacaatt atataatata tattatataa ttgtaatata taatataatt atataatata
22081 tattatataa tataatatat aatatatcat atatgttata tattttatta tataatatat
22141 attatatata atattatata taatatatat tatatataat attatatata atatatatta
22201 tatataatat atttatatat attatatata atatatatta tatattaaat attatatata
22261 taatatatat aacattattg ttataatgtt ataacattat tatatattaa atataatata
22321 tataatatta tatttatatt gaggaaaaca ttcactcaat gacagaggga agacttagct
22381 ttccaaacaa tcttctgtta aaagaaaaac tttagctgaa ttaaatttaa aggagtttaa
22441 ttgtgttttg gtgccttatg caaatgaagg gcctataata taatatataa tgtaatatat
22501 ataacattat aacaataata atcattgtta tcaattttgc ttgtgagaaa agtagtatta
22561 ccaatgggaa aatcatggta cagattgatg aaatcccttg aaatcttgtt tgtgtaatat
22621 gggactttgg tccaacgtgt tggaaaagac ctggttgagg gtaagaaagg atgggagctt
22681 tatagtatac acacagagtg ctcatattct ggagttattc tttctgaaat ccacaaaatc
22741 cagcagtgta atctactcag atggagatga aggaaaaaaa caaaacaaat gaagcaagaa
22801 gctgctggcc aaaaggggtg aggaagcagg gtcataccca tctgcaagaa gaaaatagag
22861 aacggacatg agaggggtgg atatgaggat atgagaaggc cctcttgagt gagggccatt
22921 gtttctggag gggtggggag tgaatgactg atgtaagttc aagtttgttg cgggtgcctg
22981 ctttgatcct ctgcttggtg gctccattct tcttctctct gaaggctact tcaacagagg
23041 gtgcagaggt aaacatagca gaactggccc ccaaagcttt atccactgaa tgtcagtttt
23101 tcctttaatt tcttccaggc ataaggaaat cggaggcatg tttctgtctg gctataacag 23161 ttctcctact agatcctgag gccaaactat tcacatgcca ttgttcctga ataccattgt
23221 ggacataatc atctaatttt ggctattcca tgcagaggtt tggagacaga aagctctgga
23281 ctaatgcaga tctgcattta atccctgctc ttacacttac ttgttgcatg accttaagca
23341 actcatctat gtctttaaat cttgagtttc ttgcttacaa agaggtgacc agcatattag
23401 taataatatc atgtttagag ggtggtttct gaaggttaaa tgggtgtaag tgtttagtgc
23461 attactcagc cagcagtcaa cacttaatga tgtcagacct catcattgtc cttatttttt
23521 ttgttccaca ctctgggaac ttttatctct gcgccctgta gatatgctgc tgtgactgct
23581 gacttgaatg ttacgggatc cccagcagga tctgggattc tctctgttct tgaatgcgtt
23641 gtttaggtga ggagattgat tccaagttac ttttctactt gggtgcctct gtgtttggag
23701 atgtggccgc atagctcaag tgtatctggg gtgtcttcag ttttcggata cctgtttttc
23761 ctctaggaga attcttcctc tatgtccttt aaaatatttg tcctataatc acaagggttt
23821 atatttctct gcccactcct ccatacttcc tggttttctg ggagtgcaga ggcagacaac
23881 tgcaagggag agccccRcaa ggatttgggt gatgactttg agccaggctg acatccatgt
23941 ccaagggcaa atgcagtctg gttgggagga tacaatgcag gagtcttaca acagtggcga
24001 tgccaacatt gtgggagcat gcatgtgtgt gtgcacgagt gtgtgtgtgt gcgtgcRctt
24061 gcatgcgcgt gcatgtgcag tagggtccta ctacaggttg gtggaaaaga tccctctggt
24121 tctagaacaa aaatctaaca gcaaccaaga gtccagttcc aagaaagaga aaggaaaggg
24181 ctagttaggc agggcgtctg gattctgaat aggggctgag gccttggctc agacacagag
24241 gagaatggag aaatggggtg atgacagaga catctttaaa atatttgtgg gccaagggta
24301 ggatggcttc aacttgtctg ggatgtattt gtccttagca cgcttggaat aacatagcag
24361 cagcagcagc agtcgacact tactaagact gctatgtgcc agaccctgag acaagcactt
24421 tccacacacc acatcctgcc attcttatga tgatagtgct gtgaagtagg gatgaaacca
24481 agtccttgct gactccaatc ttgtacttcc aaccaatgct tgtgagggcc ccaggccccc
24541 tacagcaaga ctaaacatgg acatatgtgt ggctgggctg agtctgtggg attggctctg
24601 gagttgggtg tgtctgagcc ctgggtagaa agggatgcta tcctaatgaa aaaacacaga
24661 ataaagatag tgtccaccaa gatgtaactg agatttaaag aagacttgat aacttatcag
24721 ttgggtgggt agtcttgaat ttcaacaact gcagatccta tctaagacca cttttgtctt
24781 gtgacaactt agttaaacat gactttagtg tggatatcag tggccaattt tgagcccatt
24841 ctatgattgg aacaaaggct tccctgtcat aggtgagtga caactatctg gtctggtggt
24901 acaggggtaa aagaatttac taagacagtt gtagataaag aaaggcagat ttattagaga
24961 aagtatgaaa atacattaca aggttgcaat gggcagcaca gccagagagg agctgactgc
25021 aaagaaacaa aggcttgctg gatatttata ggatagttcc tgggctccag ggggctatat
25081 gcagtactga taatgccaag gttgtagtga gctaacttgc aggtgtctgg tgatagttgg
25141 gtgcYggaag attctgagtt atttgctcag aagagctgtg tgtcctgggc catgaagaaa
25201 ggcaaactta cagtttatct gctttctgtc tttgctttcc cttggtactg ctagtctgac
25261 ttttttttcc ctaattagga ttccgcacat cctatgcctK tctctcagga gccttgcagt
25321 caaagtgtga tggagtgtct gagggccgag tcattgagta atggggcctc tgccctctca
25381 gccccactgc cacccaactg aggcttcctg gatgagggtg tatgccgtgg ggaaaaggag
25441 tgggatgatg tggatccccc tggggttgca ggtcatcctc ccaaatcccc actctccctg
25501 tctacccaca ggaccagtca gcatttctct aattcctctt cactctgggg cattatgatc
25561 agaaaatatc atgtaccttt tgctgcaatc ttggctgaaa gaacctcaca ctatacttga
25621 atgtctttga tttaccatct gagcagagat ctcaaactat aaagaaaatc agagtctctt
25681 gatgcccatg ttcaggacaa gttttcttgg atttcatgac tctttaggaa cagtgagctt
25741 atgggtaaag accgagactt tagtgaggaa ttccctcatc atttttctct tcttgagcaa
25801 aaccttgtct gatttggggt tgtaatgtgc aaaattattt tcttttcatt tcaccttttt
25861 ttcttaagta gtggtttctg gaaatctgag ctgctttgtg caccctgact agtctgtgcc
25921 agatcacgaa cgtacacacc aactctcaag acaccagaaa aatcaccctt tagaggaatt
25981 atctagaaaa ctagccccta tgcaaagtga ataacctttt caaaatataa tctacattaa
26041 gacttttgaa actaacacat tcctcaatca tagcaaccaa atgaattact taaagtgggt
26101 ttggttcctg ctttcattaa gggagtattt tcaggaaatt agaggtctaa tgtaaacatg
26161 gatcctttag gtttttccat tttctttgtc ttcaggctgt ttgctgccac tttcatcctc
26221 cccttatctc agtctgccag tgatggtttg tgcctctggt cKctgggtca gatccaggac
26281 taattcactc acctctgatt tctagttcca cMcttatgac gaaagcattc ttaaatctga
26341 tattcacata aaaaaggatt tgattgtctt tggcatgtct ctgcagttag ttaatcatgt
26401 cttgagcaca gaaaaatggg aagaaaatgg aaataagatt tctttgatag gaggagtcct
26461 gctaagactt gtctgtccct gagctgagat atgctaattt accttaaatc tttccataaa
26521 ccacattctg aattccagtt tataaatctt tatcttattt cccgaacctc atctcatact
26581 ttttatgtRa tctggtgggc atagatattc tcttggtgaa cctgaggaaa tctagaatga
26641 caaaggatct aaaataagta acacagttgc tcaagttcct gggccctatg gtagaatttc
26701 cttcttcaga gaaggggaga acaaggtaga taaagaaagg agcatttcat cttgcagcag
26761 cttggaagat agctgggagt ttaattttta taaaaaagaa agcaatcaaa ccatccaata
26821 cagcccattt tcaaccaaaa gtatttcaga attacctgga gatttatcta aaattatgta
26881 aaaattacct agaattacct aaaaaaattg tacaatttca tttcccttct gttacatgat
26941 atggataccc agctactatt tattagtagt agatacagac tatttaagag acaaaatatt
27001 atattccaaa aagtgtgacc cttagaaacc aaaattccaa agaagagttc ttgtaattgg 27061 caaggctggc tctgattgag tgtcaaactt cctgtacaat gatggatcaa cttagaaatt
27121 tgatagattc aaagcattct gaaattgtac aactcgctca gcacttgtat tatttacatg
27181 tcttctgtta ttttccattg aatgatgttt tcatgtatac tcagctgctt ataagggcaa
27241 tattttaaaa tcagagcaat ttctttaaaa ttaaaatgtt tcagcccagc atggtggctc
27301 aYgcctgtaa ttccagcact ttgggaggcc gaggcaggtg gatcatgagg tcaggagWtc
27361 gagaccatcc tggctaacac ggtgaaaccc catctctagt aaaaatacaa aaaattaact
27421 gggcgtggtg gtgggcgcct gtagtcccag Stactcggga ggctgaggca ggagaatggc
27481 gtgaacccag gaggtggagc ttgcagtaag cccagatggc gccaccgcac tccagcctgg
27541 gtgacagagc cRgactctgt ctcaaaaaaa aaagtttcag caaaatactt tttaaaatgc
27601 actgtaatta ccctaacaat attacactgt tacagatagt ttaagaataa taaaaaatgt
27661 aattcataaa ctcactcctt taatacaaca aacctgatta atgttctgtg ttccttatta
27721 gactttctcc catgtatagc tttacaaagt ggtagttgat gagtaagtac aatttgtgat
27781 atttttttca cgtgagaaca aactcaatat gtcaattact tcatagattt ttaatttata
27841 aaaattttct catatctctt ataaaaataa aaaaagattt gatttcagta aacacacatt
27901 tggagagaaa gttgatcctc atataaactc aaccatagac cattcagtgt gttgcaagtt
27961 ataaatgcca tggaggaaaa aaatcaagca gagttaggaa gattgggagc acagggttag
28021 ttggtcaaag ggtgggagag gatagacctc attaagaaag tggcagacct cattgagaaa
28081 gtgagggagt gagtcacaca gacacctgga ggaagaaaat gcaagagagg gtaaacagtt
28141 gctgcaacac cctgaggtgg gagcaggctc gggaggccaa gcaacaggaa ggacaaaagt
28201 gcacgtgttg tgtagttaag attgggggtg tagcaggatg taaatcagag aggtgagagg
28261 tgacagaccc ccagggggtc ttcttgttca ttgcaagcaa tttggctttt gttgggtaaa
28321 gcagaggttt gaagagagga gtaatttgaa aggatcactc tagcttctgc tttgaaaatc
28381 aattataggg gacaagggaa ggatcagtgc aaagactagt gcaataattc aggcaagaga
28441 tggtggtggc ttggatcagc aaagatggcc atgagaagtg gtcacatggc tgagttctgg
28501 ctgtatttgg aaagtaggtt cactgggact tattggtggc ttgagattga tgtgctggag
28561 aaagagaggt ataaggatac ctccaaggat tttgatatgt gcagctgaaa aaagatgaag
28621 ttgccatcaa ccaagatgag aatgatggtt ggaagagcag attttgggag aagaacaggg
28681 attcattctt gacaggttat ttttgtgatg tctggaatat agacaagtga aggcattgag
28741 tcagcaggtg gacatgagaa cctgaagttc aggggaaaag tgtggacggc aggtgtaact
28801 gcaagagtgt aatcagtata gagatggtgt ttcaaaccag ttaactggat gacatcatgt
28861 ggggagtgag tgtggacaga gaagaaaagt gcttcaagga ctgaaacttg aggtggtgga
28921 gagaagagga gatgtgaagc agtagcctgt gggtcctgaa gaaagatgtt ggagaaattg
28981 ttccactttg acagaggctg cttatagctc aaggtaaggg gaagacgcag gactgaggat
29041 tcctaagcaa catggtggta attgacgata ttgataacag cataaagaca tcataattta
29101 aactaattat taacaaaatt gaaatttaaa gaaacaagta atgcaatgtt tccaaagtgg
29161 attcaaattc cataatatta ttgcaaaaca aacaaaccaa acaaacaagg aaaacaaaga
29221 aagaagggat tctaacataa aagaatttaa aaataagtaa atcagctcgg aaaactcagc
29281 aggctatatc ttcctggtgg ttagaaatat ctgcttatta aaaggtttca aaggtccttt
29341 gggaatagaa cttattgcaa tgtgtttggc tgtacatttc ttacactttt ttttttaact
29401 gaggagtcaa ttaaaatatc ctgaagtgac tgtccataga acacattttg aaaacacaaa
29461 tgctatataa tcacaaatat atctccctcc cctttgctag tgattgttac caaactgcct
29521 ctgctagcta ggattcaact ctttctctta acaactatgc tttgatggaa caattttttt
29581 agatacaaat attgtcaatg agaacaatta ttatacagtg cagtcacaga agagaaacag
29641 aaaagaaagg gaggtgcaac aaaatgaagg taaatattag ccttcacact taaatacatt
29701 tgatgagggg ataaaatgta catgtaggtg tggatttatg ggctgtgttt ttcaaacaat
29761 taccaaatat ttattaacca ccaactcagt gtaagctagt acactaggtg cctatagtga
29821 tccagcaggc tataaggcag gatttctgcc cttatagaat tttggggcat attctcagta
29881 tcttttgtat ctctcgccct cttttctttt ttttgtgaca caagatgtca ttctgtcatc
29941 caggctgtag tgcagtgaca tgatcatggc tcattgcagc cttgacctcc caggctcaag
30001 cgatcctctt gcctcagcct cccaagaagc tgggaccatg ggcatgtgcc atcatggcag
30061 actaattttt aaattttttg tagagatggg gacttactat gttgcccagg ctagtgttga
30121 actcctgggc tccagcagtc ctcccacctc agcctcccaa agtgctggga ttactggtgt
30181 gaaccatcac tcccagccct ttcttttgct ttgttatttt aaaaactttt ctttattctc
30241 tttctgttac cttttaataa actataagaa gtctttcaaa acaaaaatgt cttaatgtca
30301 gtgggttagg ttttgtcctg cattattttc ttttacccca tggtggggaa aaaagcaaaa
30361 aactgtttgg tgcctataca atgccttatc gcacagcttt ggtttgtgtt tactccagtg
30421 tcgtctttaa ggtggtgagg tcagtgcagc tggcctgggt cagaactcag ggtcacttca
30481 tgccagatgc tcaccacctc tgcagtgttg tatgcagaga tccaaattca tccttcaggg
30541 aaggatgaac acttattctc tgggatgttt tacagtgaaa atcagaagtt gctctattgt
30601 gccctcatgg cctagctact tccactcttt tgaagatctt acctggtctc atgggtttaa
30661 tttcatctat acagtgacat atcccaaatt tgtatctcta gcccaatatg tctcctgaat
30721 ttcagaagca Ratattcatc ctactgatgg gttcacatct ccagttttat gtctaatgag
30781 gtgtcaagct gaatatggcc aaaactagtg taatcctact ctaaaaccta taccacctgc
30841 catttcctaa ttcagtaact agcaacccta tttgaccagt tactcagggc cccaaacctc
30901 tcttgactgc tctcatatcc tgtccatcaa gaagtcctac tagttctacc ctcaaaatct 30961 atctgcatcc caatcatgtc tcaccacctg cacttccccg ccctggtcat agccaccgtc
31021 tctgtctcac ctggatacct catcccttgc cattcttaag agtgttttca cattcagagt
31081 gtttaatacc tacgtcaagt ttgaggtcat gtcactcctt agcttgaaac actccagtgg
31141 tcttcatcac acttaataaa agccaaggtg ctcagggtga ctcactcgca atctagtctc
31201 tacccctctc caaccagctc tcactgctct ggagttcctc atgccctgtt ggccatgtgg
31261 cttccctact ggccctcgga cacaccaggc ttgcctccat ggctggactt tcatgctgcc
31321 tgccctttcg acctgggctg tttattaaat gtctccttcc tagttggcct tcccaggaca
31381 tctggcctga aattgctctc ctcctgctgt atttttctcc ttaagtggat cacactctaa
31441 gatcttttgt aacttttttt tatttcttta tgttacttat tgtcctcctg taggacatga
31501 attccacaag ggcaggagat ttttgtttcc ct ttgctctg tgtggtgcat tgctgtatcc
31561 ccagcatctg aaacagtgat tggcatgaaa gaataaccct cactggttgt ctgggttcag
31621 tattttgctt ttctaagctc agttgatgca gaacaactgg ttttctgggt tcagtatttg
31681 cttttctaag cccagttgat gcagtgttgg tatgtgcggc catgttagat gttagaacac
31741 tgacatcctt accactgatg agtcaatagc cactgccccc gaccctcctg atattttatg
31801 gtccgagtaa ttactagatg catctacatt taaggctgca aacatgaatt tactggagga
31861 agcacagtgg tggtggatga cccaatctct ctctcaaact taccaaaatc accaaggaat
31921 cataaatcca cccctctttg catcttccaa gcaaaggaaa ttgtagaaaa cacaagtgaa
31981 actgtttcac agagatatca gcaatacata gcaaatttga gatgatggag attaagagga
32041 aaattaaatc attcttaagt ggtcaaggta aaaacattat tgtgYggttc gctatagtta
32101 catttaaaac agtccgaagt caaacaactc tagtctgaYt agtcttgtca ttgatatgtg
32161 ctgtcttaga attctccaga gagacagagc taataggaga ttatctatct atgtatctat
32221 gtatctacct aatctatcta tactctctct atctatttta aggaactgac tcatgagatt
32281 gtggggcctg gcagtctaaa agctacaagg caggctggca gactggaaat tcagataaga
32341 gttggtgttg tagtcttgac tctgaattcc ataaggcagc cagtcggaat ttcaggcggg
32401 gtttctgtgt tgcagtcttg aggcagaatt ccttcttctt tgggaaacct cagtctttgc
32461 tcttcaggcc ttctgctgct cacattccac agtgctgtcc ttctggccat ccttcatgct
32521 tttgtgttgc ctgtcccatt gcccttaatc ttatatggaa aaatggaaat aaattcagag
32581 cggaaactta tctaaaagtt ttgagggaaa aatgatcgaa accagaatta ttcacaggac
32641 aacttgttct atgaataatt tttgaaaagg aaccatttcc tctacagctg gcttattatg
32701 aggagcttga tgataaaata ttggcaaggc ctccagtgga catttatcgt gttgtgacag
32761 atcccagaaa tgaatctggg tctcccgact tcaatacagt tctcttctta ttacataatg
32821 agagaatatg attttctact cttttctttt actttacttg ttgagaaaca actaatattc
32881 aattaaaagc atcaatctta catattcagt tgaatgagat tcagcaatca tatcccccat
32941 gtatcatcat ccatatcacc atcccaacag cacagaaagc atttcttctt cccagagagt
33001 tgccctcaca cctttccaat caaatttcca catactctct agtttccagc atgatagatt
33061 ataatttgcc tattgttggg cttcctatag gtatgatatg taatatgtag tcttctgtgt
33121 ttagtttctt ttgcttagca taatttttca ggagcaaggc tttattattt ttttgtttgg
33181 aaaYgaactc agagttacat aacatgatgt t ttgacagt catcctatgg ttatatcagt
33241 atttccttcc ttttcattgc tgagtagttt acattaaaaa aaggatccat tctcctgttg
33301 atagacattt ggattatgtt taatttttgg tattatgagt atggcattta tgaacattct
33361 tttacaagtg ttttgtggat atgtttgtta attctcttgg gtaagggggg agttattgag
33421 ccatacagta gatgttcttt aactttttgt taggttttat atatatatat atatatatat
33481 atagtgtgtg tgtgtgtgtg tgtgtatata tatatggtgt atataattta tatacactaa
33541 aatacacaca tttttaagtg taaagttcaa taagttttga tacatgtata ctccattggc
33601 tttgttttgt attgctataa aataatacct gaggctgggt aatttattaa gaaaaagttt
33661 atttggctca tgattttaat ggctgcaaag ttcaagactg ggcaactgca tctggtgagg
33721 gcctcaggct gcttccaatc ctggtggaag gttaagggga ggtggcttgt gcagagatca
33781 catgggagag aagaagcaag gggtggggga gtgctaagtt ctttttaaca gccagctccc
33841 atgggaagta atagagtgag aactcaccac caagggaggg gattgaagga gggaattaat
33901 ctattcatga gggatccacc cccatgaccc aaatgctccc ccttaagccc caccttcaat
33961 attggggatc aaatttcaac atgaggtgag gagggtacaa atatccatgc ataccacctc
34021 tgaaaccatc atctcaattg acatattcca caaatctctc tcatactcct ttataagtaa
34081 ttgctaccct tcatcttcca ttctaggtac ccactcactg gccttgcagt ttgggaacat
34141 tatataaatg ggacgatata atatgcattc ttttaaaact ggcttctttc attcagtatg
34201 tttctaagat tcatcagtag ttcttttttt tttttttgct gagtagtgtt ccattgtatg
34261 aatatagaat agtttagcca tatatgtgct gacggtcatt ggtcttgttt ccagtatttg
34321 gctatatgaa ttgaactggt atgaacattt gtgtacaagt ctttttgtgt gcataagttt
34381 ttatttctct taggtaaatc cccaggaaga gaatttctgg agtgtaacac aagcacataa
34441 tcagaaactg ccaaactatg ttcactgtat catgttacac tccatcaatg atgcatgaga
34501 gttctaggtg tgccacatcc ttgccaaaat ttggtattgt cagtcttttt tattagctat
34561 gaaatagaat ctcgatattg tggagccaag atggccaaat aggaacagct acagtctaca
34621 gctcccagcg tgagcgacac agaagacagg tgatttctgc atttccaact gaggtactgg
34681 gttcatctca ctggggcgtg tcggatagtg ggtgcaggac agtgggtgca gagcactgag
34741 cgtgagccaa agcagggcga ggcatcgctt cacccaggaa gtgcaagggg tcagggaatt
34801 ccctttccta gtcaaagaaa ggggtgacag atggcacctg gaaaatcggg tcactcccac 348 61 cctaatactg tgcttttcca atggtcttag caaatggcac accaggagat tatatcctgc 34921 acctggcttg gagggtccta cacccgtgga gcctcgctcg ttgctagcag agcagtctga 349 81 gatcaaactg caagttggca gcgaggctgt gggaggcgtg cccaccattg ctgaggcttg 35041 agtgggtaaa caaagcagcc gggaagctcg aactgggtag agcccactgc agctcaagga 353- 01 ggcctgcctg cctctgtaga ctgcacctct gggggcaggg catagctaaa caaaaggcag 350- 61 cagaaacctc tgcagactta aatgaacctg tctgacagct ttgaagagag tagtggttct 352 21 cccagcacgc agctggagat ctgagaacgg acagactgcc tcctcaagta ggtccctgac 352 81 ccccgagtag cctaactggg aggcaccccc cagtaggggg cagtctgaca cctcacacag 353 41 ctgggtactc ctctgagaca aaacttccag aggaacgatc aggcagcaac atttgctgtt 354= 01 caccaatatc cgctgttctg cagcctctgc tgctgatacc caggcaaaca gggtctggag 354 61 tggaactcca gcaaactcca acagatctgc agctgagggt cctgacagtt agaaggaaaa 35521 ctaacaaaca gaaacgacat ccacaccaaa accccatctg tatgtcatca tcatcaaaga 355 81 ccaaaggtag ataaaaccac aaagatgggg aaaaaacaga gcagaaaaac tggaaactct 35S 41 aaaaatcaga gcacccctcc tcctccagag gaacacagct cctcaccagc aatggaacaa
35701 agctggatgg agaatgactt tgacgagttg agagaagaag gcttcagatg atcaaactac
35 61 accgagctaa aggaggaagt tcgaacccat ggcaaagaag ttaaaaacct tgaaaaaaaa 35821 ttagatgaat ggctaactag aataaccaat gcagagaagt ccttaaagga cctgatggag 35881 ctgaaaacca tggcacgaga actacgtgat gaatgcgcaa gcctcagtag ccgatttgat 35941 caactggaag aaagggtatc agtgacggaa gatcaaatga atgaaacgaa gtgagaagag 36O01 aagtttagag aaagtagaat aaaaggaaac gaacaaagtc tccaagaaat atgggactat 36061 gtgaaaagac caaatctaca tctgattggt atacctgaaa gtgacaggta gaatggaacc 36X21 aagttggaaa acactctgca gggtattatc caggagaact tccccaatct agcaaggcag 36X81 gccaacattc aaattcagga aatacagaga acaccacaaa gatactcctt gagaagagca 36241 actccaagac acataattgt cagattcacc aaagttgaaa tgaaggcaaa aatgttaagg 36301 gcagccagag agaaaggtcg ggttacccac aaggggaagc ccatcagact aaaagctgat 36361 ctcttggcag aaactctaca agccagaaga gagtgggggc caatattcaa cattcttaaa 36421 gaaaagaatt ttcaacccag aatttcatat ctagccaaac taagcttcat aagtgaagga 36481 gaaataaaat actttacaga caagcaaatg ctgagagatt ttgtcaccac caggcctgcc 36541 ctacaagagc tcctgaagga agcactaaac atggaaagga acaaccggta ccagccactg 36S01 caaaaacatg ccaaattgta aagaccatca aggctaggaa gaaaatgcat caactaacga 36661 gcaaaataaa tagcaaacat cataatgata ggatcaaatt cacacataac aatattaacc 36721 ttaaatgtaa atgggctaag tgctccaatt aaaagacaca gactggcaaa ttggataaag 36781 agtcaagacc catcagtgtg ttatattcag gaaacccatc tcacatgccg ggacacacat 36841 agactcaaaa taaagggatg gcggaagatc taccaagcaa atggaaaaca aaaaaaaggc 36901 aggggttgca atcctagtct ctgataaaac agactttaaa ccaacaaaga tcaaaagaga 36961 cacagaaggc cattaaataa tggtaaaggg atcaattcaa caagaagagc taactatcct 37021 aaatatatat gcacccaata caggagcacc cagattcata aagcaagtcc ttagagatct 37081 acaaagagac ttagactccc acacaataat aatgggagac tttaacaccc cactggaaac 37X41 attagacaga tcaacgagac agaaagttaa caaggatatc caggagttga actcagctct 37201 gcaccaagca gacctaatag acatctacag aactctccac ccaaaatcaa cagaatatac 37261 atttttttca gcaccacacc acacctattc caaaattgac σacatagttg gaaataaagc 37321 actcctcagc aaatgtaaaa gaacagaaat tataacaaac tctctcttag accacagtgc 37381 aatcaaacta gaactcagga ttaagaaact tactcaaaac cgctcaacta catggaaact 37441 gaacaacctg ctcctgaatg actactgggt acataacgaa atgaaggcag aaataaagat 37501 gttctttgaa accaacgaga acaaagacac aacataccag aatctctggg acatatttaa 37561 agcagtgtgt acagggaaat ttatagcact aaaagcccac aagagaaagc aggaaagatc 37S21 taaaattgac acactaacat cacaattaaa agaactagag aagcaagagc aaacacattc 37681 aaaagttagc agaaggcaag aaataactaa gatcagagca gaactggagg aaatagagac 37741 acaaaaaacc cttcaaaaaa tcaatgaata caggagctgg ttttttgaaa agatcaacaa 37801 aattgataga ccgctagcaa gactaataaa gaagaaaagg gagaagaatc aaatagacgc 37861 aataaaaaat gacaaaggcg atatcaccac cgatcccaca gaaatacaaa ctaccatcag 37921 agaatactat aaacacctct atgcaaataa actagaaaat ctacaagaaa tggataaatt 37981 cctgttcaca tacactctcc caagactaaa ccaggaagaa cttgaatctc tgaatagacc 38041 aataacaggc tctgaaattg aggcaataat taatagctta ccaaccaaaa aaagtccagg 38101 accagatgga ttcacagccg aattctacca gaggtacaag gaggagctgt taccattcct 38161 tctgaaacta ttccaatcaa tagaaaaaga gggaatcctc cctaacgcat tttatgaggc 38221 cagcatcatc ctgataccaa agcctggcag agacacaaca aaaaaagaga attttagacc 38281 aatatccctg atgaacattg atgcaaaaat cctcaataaa atactggcaa accaaatcca 38341 gcagcacatc aaaaagctta tccaccatga tcaagtgggc ttcatctctg ggatgcaagg 38401 ctggttcaac atacacaaat cgataaacat aatccagcat ataaacagaa ccaatgacaa 38461 aaaccacatg attatctcaa tagatgcaga aaaggccttt gacaaaattc aacaaccctt 38521 catgctaaaa actctcaata aattaggtat tgatgggacg tatctcaaaa taataagagc 38581 tatctatgac aaacccacag ccaatatcat actgaatggg caaaaactgg aagcattccc 38641 tttgaaaact ggcatgagac agggatgccc tctctcacca ctcctattca acatactgtt 38701 ggaagttctg gccagggcaa tcaggcagga gaaggaaata aagggtattc aattaggaaa 38761 agaggaagtc aaattgtccc tgtttgcaga tgacatgatt gtatatctag aaaaccccat
38821 catctcctta agctgatagg caacttcagc aaagtctcag gataaaaaat caacgtgcaa
38881 aaatcgcaag cattcttata caccaataac agacaaacag ccaaatcatg agtgaactcc
38941 cattcacaat tgcttcaaga gaatgaaata cctaggaatc caacttacaa gggatgtgaa
39001 ggacctcttc aaggagaact gcaaaccact gctcaatgaa ataaaggagg atacaaacaa
39061 atggaagaac attccatgct cataggtagg aagactcaat atcatgaaaa tggccatact
39121 gcccaagtta atttatagat tcaatgccat ccccatcaag ctaccaatga ctttcttcac
39181 agaattggaa aaaactactt taaagttcac acagaaccaa aaaagagccc acattgccaa
39241 gtcaatccta agtcaaaaga acaaagctgg aggcatcacg ctacctgact tcaaactata
39301 ctacaaggct acagtaacca aaacagcatg gtacttgtac caaaacagag atatagatca
39361 atggaacaga acagagccct cagaaataat gctgcatgtc tacaagtatc tgatctttga
39421 caaacctgac aaaaacaaga aatggggaaa ggattcccta tttaaσaaag ggtgctggga
39481 tatctggcta gccatatgta gaaagctgaa actggatccc ttccttacac cttatacaaa
39541 aattaattca agatggatta aagactgaaa ttttagacct aaaaccataa aaaccctaga
39601 agaaaaccta ggcaatacca ttcaggacat aggcatgggc aaggacttca tgtctaaaac
39661 accaaaagca atggcaacaa aagacaaagt tgacaaatgg gatctaatta aactaaagag
39721 cttctgcaca gtgaaagaaa ctaccatcag agtgaacagg caacttacag aatgggagaa
39781 aatttttgca atctacttat ctgacaaagg ctaatatcca gaatctacaa ttaactcaaa
39841 caaatttaca agaaaaaaac aaacaacccc atcaaaaagt gggcaaagga tatgaacaga
39901 cacttctcaa aataagacat ttatgcagcc aaaagacacg tgaaaaattg ctcatcatca
39961 ctggccatca gagaaatgca aatcaaaacc acaatgagat accatctcac accagttaga
40021 atggtgatta ttaaaaagcc aggaaacaac aggtgctgga gaggatgtgg agaaatagga
40081 acacttttac accgttggtg ggactgtaaa ctagttcaac cattgtggaa gtcagtgtgg
40141 cgattcctca gggatctaga actagaatta ccatttgact cagccatccc attactgggt
40201 atatacocaa aggattataa atcatgctgc tataaagaca catgcatata tatgtttata
40261 gcggcactat tcacaatagc aaagacttgg aaccaagcca aatgtccaac aatgatagac
40321 tggattaaga aaatgtggta catgtacacc atggaatact atgcagccat aaaaagatga
40381 tgagttcratg tcctttgtag ggacatggat gaaactggaa accatcattc tcagcaaact
40441 atcgcaagga caaaaaaccg aacaccacat gttctcactc atagatggga attggacaat
40501 gagaacacat ggacacagga aggggaacat cacacaccac ggcctgttgt ggggtggggg
40561 gagggggjgag gcatagcatt aggagatata cctaatccta aatgacaagt taatgggtgc
40621 aatacacaaa catggcacat gtatacatat gtaaaaaacc tgcacgttgt gcacatgtac
40681 cctaaaactt aaagtataat aaaaagaaga agtagaatct cattgtgatt ttaattgttt
40741 acatttatct aataactagt aactttgtgc actttgtcct gtgcttattg aacattgata
40801 tattttc tt tgtgaaatat cagtacaagt cttttcctca ttttaaaaat tgggctattt
40861 tatctttttc atatgaactt gtaagagtta tttatgaagt atagatacaa gtctttcatc
40921 tgatatgcaa attatgagta ttttgtctgg actgtggctt agtctattca aattctaatg
40981 atgtctttga agaagaaaag tttctaattt taataaagtc ccagctatga tttatttttc
41041 tttcatgatt agtgattttt gtatccattt aaaaaatatg ttcctacttc aggtttaaga
41101 tgttctgtta tgtaatacaa tccattttta tttcattttt ctgtataata tgaggtagag
41161 ctttttcaca tagagagtca atttttctat cattatgtgt cgaaggcagt gtttttcaca
41221 ataaacttat gttggcactt taatcaaaca tcaatttact atatattttt gagtctactt
41281 ctggactctc tcttctttga tcaacatgtc tgtctttatg cccataccac actgttttca
41341 ctatggtagc ttttatatta agtcttaagg tcaggttgtg taagttctct gactttgttc
41401 tttttcttta accatgtctt gggtattccc aggactttaa tttgccatgc agactttaga
41461 tttccataga agctttagaa gcagattctg ctgctgggag aataagttac actgacctca
41521 ggacaaaaga tgtacatgaa ctaaataaag gacgacaaat gcagaccaca gcaataaagt
41581 ctgtggaatt agtatgtgag aaattacaca atggtctaaa atattagtct tgaagggatc
41641 ttaatgεatga tttagtcatt tcacatgtgc aaactgttaa gactgctggc tgtttttcac
41701 atggccεacca gcccatttct ttttcctgag tgtctgcagt ccacagagct tcttctggct
41761 ctctatgctc catctgttct cggcccagga gttcccatgg gacctcccaa gggtgactca
41821 ggtctcstct tccgataaga taaaagaaat aagacagata ttcggggtag agatgtaaga
41881 gcatggtgaa agacagactg ctcctgttta gatccatata taaaagcttt attttttgaa
41941 tcccaaattc catcccttgg tcatctgtac tggttcattc aataaatatt tctgaggctg
42001 ggcatggtga ctcaagcctg taatcccagc actttgggag gtcaaggttg gtggatctct
42061 tgagccσaga tgtttgagac cagctttggc aatatggtga aaccccatct ctacgaaaaa
42121 tacaaaaatt agctgggcat ggtgatgtgt gcatgtagtc ccagctattc tggaggctga
42181 ggtggg-agga tcacctgagc ctgggaggtg gagactgcag tgagccatga tcacaccact
42241 gcactccatc ctgggtgaaa gagtgagacc ttgcctcaga aataataata ataatgataa
42301 taagtaaaca tttctgagca cctacttggt gctcttccag gcacatgagc tatatcaata
42361 gacaaasactc acaaaaataa tMttgccttc tggaggtcat attccaatgg ataaaacaga
42421 aaataataaa catgatgcat aagtagaatg ttagaagtga tgaatgcctt agaaaaagat
42481 tggagcaggt taaggagatg gggattggga gaggagacat tgcaattcaa aattgattgg
42541 tcaggaactc aaacaaatac ttggacacYg atagcagcat tattcaaaat agtcaatagc
42601 tagaagcaac ccagatgccc attaagggat gaatggataa acaaagtgtg gtaggcacac 42661 acagtggaat attattcagt cattagaaac aataaagtac agacccatgc tacaatatga
42721 acaaaacttg gaaagattat gctaagtgaa ataaggcagt cacaaagggc acttattgtg
42781 tgactccatt tataggaaat attcagaata gataaaccca tagaatcaga aagcagattg
42841 gtggtggcta tgggtttgtg gtggaagagg aagaatgggg acttcatgtt aatgggtatg
42901 gggttatact cggggatggt gaaaatgttt tgaaactaga tagagttagt ggttgtacca
42961 cattgtgaat gtaccaaatg tcactaaatt gtgcacttcg aaatagttaa ttttatgtta
43021 tgtaaatttc agcgcaattt ttaaaaatca gaagcaaaaa aagaacagaa aattgagtag
43081 ttaggctaag tctcacagag aatgtacagt ttgagtgctc acttggagga ggtaagttag
43141 ctcttggagg aggtgggtaa caggaagaag ctgtccaggc agaaggaaca atgtctgcct
43201 agtgccttca aggaacagca atgaggatac ggggttggag gggaggggtc agagaggtga
43261 ttggtggtgt tccatcgtgt ggtacctccc agcttctgta aagacgttgg cttttcctct
43321 gggtgaggtg gaagactttg gaggccccct tgatttgacc taggttctaa cagaatctcc
43381 agagtgtctg ttttaggaat atacttaaga gggtacaagt ggaagcaggg atagcaattt
43441 agaagcagtt attaaaatcc aagtgagaga ccatggtggc ttggacaagg atggtggcat
43501 tgagaatgga gagatgcaat tgcaggtagg atgtcctttg aagatgaaac cataagttgt
43561 cctgatggat tgcatgttca atatgtgagg aagagaagag tcaataataa atggagtctt
43621 ggtctgagcc aacattcagc atggagttgt catcattaca attagaagac aatgggagat
43681 gctgaatttt ctttggggca agggaggcaa ggaggctgga ggagatcaga agttctgttc
43741 tggagacatg aagcttttgt gaattccact tgttccttga atatatgatg gtttcttctg
43801 tttttgtttg tttgtttttt taaattttag attctaaggt acatgtactt gtttgttaca
43861 aaggtatatt gcattactgg tggggactgg tcttacccaa attgtgaata ttgtacccag
43921 taggtaattt ttcattcatc accccctacc ctccctactt ttggagtccc cagtgtctat
43981 tatttccatc tttatgtcca tgagtaccca tggtttagct cccacatatg agtaagaaca
44041 tgtggtattt ggttttctgt ttcttaactg gttcacttaa gataatggtc tccagctcca
44101 tccatgtagc aaaggacata atctcattct ttttatggct gaatagtaat ccgtggtgca
44161 taggtacaac attttcttta tctagtcaac cgttgatgga cacttgagtt ggttccatga
44221 ctttcctatt gtgaaccgtg ctgcagtgaa catactagta gaggtggaga ggtgtctttt
44281 ttatacacta atttcttttc cttagaaaag tagtgagatt tctgggttga atggtagttt
44341 tacttttggt tcattgagaa atcttcatac tgttttcctt agagattgaa ctaattgaca
44401 ttcccagcaa caatgtataa gcattccctt ttctccatat ccatgccaac atctgctgtt
44461 ttttgagttt ttgataatag ccattcagac gggtcttctg gtttttggag gggaggattg
44521 ggtgaagcaa gaaggagttt ggagggaagg agtggaggct tgagtgggcc tagagtttgg
44581 agtatgggca agaaggatcc cagagacaag cactttgccc acagctacac agctaatgga
44641 gctggggggc ccagcatatt ctccagaggc ccaggctagg ccgtctaggg gcatgcttgt
44701 tctgccccat ccactgcagg tcctgaaaac attttcatca ataaaaaaaa ataaaaaaac
44761 agaataaaaa tgatacccag atgtcctcta gtgaaatgag gggaaaaaaa acatccatcc
44821 ccRgcttatt gtgagagtca ctgaatgaga gcctgactca ctgaaattca tataagatta
44881 atgtaaccaa gttccctgtc ttttgacact ggtttacagt aagagcaggc cacacatggc
44941 cagctctgga gtgtgttagg acatttacat tttacatttc agtgtgatat ctgctaagtc
45001 aaatgaagaa gtcttgaaag ataccttcta agttcggaag tatttgagtg tcacattcca
45061 tatgccagca gttagttgtt gccctcaaaa cataaggttt tgtttgttct tttgtttttt
45121 gtttttttaa tggttatgta agtgaagtag attataaata ggcacataca ggatttcaaa
45181 actgtaacaa aattaagaaa aagctggttc aatgagStta gattctatga gattaatctg
45241 aaaagggaga gtagttatga gaagtcttaa aaaagtgggt gtttgccaga gaaacaagcg
45301 gacactggaa gatttctgat taagttggca gaaatttatg ggtgcttaaa atgccttgct
45361 ttattcatgt attagaagcc cttgcctttt tgcagtttgt cttaagttgc tataaactac
45421 tctctgttat gttgaatggt gcctgaatag tgagaagcca aaataattta gttcttttca
45481 aagaagaaat tatagactag cttattttaa taacccagtc caaattataa aaagaaaagc
45541 tttaccaScc taatctctgg tatagagaat gttctctttt tttagttgac attgggggga
45601 Raaaagcttg actttgaagt tcagcaagtc tggtttcaac cccagccaca actgggtgaa
45661 ctttgtcaaa ttacttaaac agtcttatcc ttgggttttt atttgtaact ataaaatttg
45721 aStgatgtta atgataagta ccacagagta ttgtactttg aatgaaaggt cttaattgtc
45781 aaatgaacaa ctgaattatt ttataggaag agttcaactt taataaatac tcctgcagaa
45841 tttcatcatt atgatgttaa aattgatgga agctttattt tttaaactga gaaactaatg
45901 cttacgtggc ctagtttaag aatgaatgct ccaacttaat acatgtttta aaaagatgtt
45961 ttgggaYacc aaatgtaaaa gaattccgag tttgtgttat tttattgaac aaacctattc
46021 agcacttggg gaatcgcagg cagcattgca gactcgctgg ctcctggctg tgatctcaca
46081 cccaaactgc aataatatcc tgataaaacg gacttccaca agtaggtcaa gaataataat
46141 gtgcagacct aattcctcta atttacggcg aacatctcat ggtcaatctc cccgcggtca
46201 aaggactgtg tatctcttcc tctcagagcc actccacagg ctgaaaggct gactaaaccc
46261 ctgacagata agagattcaa gagtagtccc agcccccatg gggagcaaag acgctggctc
46321 aaaaaacgta ctgataactc tcccttttgc agctactcct ttctgaacct tccacaagca
46381 gtggcagttg gattctgtga ttagtctagt cttcagagcc agccttcttg agttcaaatt
46441 ctgacttcac cccttaatgt gaagtgacat gggcaagttg cttaatctct ctgtgcctca
46501 gtgtccttgt ctgtaaaatg ggcatcataa taatagcgcc tgccacattg ggtgagtgtg 46561 agaatgaagg aattaataca tgtaaatcac ttagactgtg tctggcatag aggacattct
46621 aaagaaaagt tagctattat cattatatta ttatatgggt ctggaattag ttcctgaatc
46681 cttctgagat gtgatgactt ataaacgtag gttgagttta ctcatgatag ggtcatcgca
46741 actatgcata gctaaaatca aattttgctt ttcaagtttg ttttacctgg agccctagag
46801 ttcagggtta tggttttctt tgtcactccc cttgagggaa gcttcttagt cacactctcc
46861 ttctctttct ctgcactcta tgcactctag aaaagctcct tttttttttt cttcatccag
46921 gcagagaggc c-tactgggac ttaaatccaa ggagctgaaa tctgttttgg gatggggtgg
46981 agtcacattc tggaacctag acagagaatt tctaagttcc agaaagtgct gcttacttcg
47041 catttcctct cccccacctt tgcttttgaa actcctggca ccaatgctgc caaggctggc
47101 ggagctttcc tgagtggtgt ctgccaaatg aggagtcaag gaatatctgg aaaggcagcc
47161 tccaggtccc σgatgtcaag accatttaga actgaaagtg tcccaatatc ggggtacagg
47221 caataagcat tagttattaa tcagcctgag aagttgattc taaaatagga ggaaatgatt
47281 caattatttc c-tctcaaggg attactcaat gttgttttta tgtttaaata tt tatttgtc
47341 aacatcaaga attcttagta catgatKcac cagcattttt gaacaagtca tagatttggc
47401 cacaaatcaa atttcaggat gggaggagtg tctccccttt aaaatagaag agagtgagta
47461 gtctatgagg sgggacctac aaagactgga aactattctt agctccgtca ctgactccaa
47521 gttcatcccc tctgtctttc agtttgggta agcatcaatt acttatctaa aatttgtaat
47581 aagaaaagtc ttcataattc atgattgtgt ttatctttat gttagtaaat ttctatgttg
47641 gKtctattct tccccttata ttttaagaaa agaagtaaga aagtaaatga ttatttttct
47701 gaaagaaaaa attaatgtat ttattattat tcatagacct tcaactactc ttagaaagcc
47761 tttggtgact cctgggaaca agctgagtca ggaacaaaag tttgagggtt tggggttgag
47821 aataggacaa ttacttggct aatgctttag tctagttctg attttgctac tccttagttg
47881 ctttgtgatg actacttgca catgtgtctg tttgtgagtt atttttgtga gcatgctgct
47941 accagcctgt gtggatgtct gtggtttcac atgatacatt ttattttcta aagtctactg
48001 aattttatgg tttttttttc aaaaatagaa actcatattc tttccttctt aatttagttt
48061 ctttcaggac attctcatga gactggtgaa atataactgc gaagtagcat gataactgtg
48121 aaataRcatg atcattgtga aagctatatg acccaaaact tccataggaa taagtgcaat
48181 gcttgcatat ctgaaacctg ctgttacatc tctttgcact taataaatat gtgttgactg
48241 attcattctc σtgggtggtg ctgagaaagt aaaaatcatg gctgataaaa at tctgttta
48301 tggttttgtc taacttattt ttcagttgag atataggcta ctcttcccaa ctcagtcttg
48361 aagagtatca ccaactgcct catgtgtggt gaccttcact gtcgtatgcc agtgactcat
48421 ctggagtaat ctcaacaacg agttaccaat acttgctctt gattgataaa cagaatgggg
48481 ttttggatct tagcaattct cacaattctc atgtattcca cagcagcaaa gtttagtaag
48541 tattgccttc taagtataat ttaaattttt ataaattaaa taatttcaag aacatttacc
48601 ttgttttaag cagtttgctt ccagttgttc cagttgaatt gtaaactgaa aaatatattg
48661 cttttgtaca atcatttttc attacaaatc tatcagaaga aattctttgt aatgaatata
48721 tcatcagttt ggctttgcat attcaaatgc agcagaattt aatgtggtgc ctgcacatgg
48781 gaagtgttgt ggatgtttat tgactgacac acagtttgtt tagatagata aggctgcttt
48841 tccattggat aactgtgggg gatttagctc caaattaatt cattaacatt tcataagaga
48901 tcttaacagt tacttattct ttcccaaggt atcacagtat atgaccggct tctaaattta
48961 atcctagaag aaaatattga gagtataaga attatgatct tttcatttga tcatttcagg
49021 attgtcttta tatcttttat ttgcaggtaa acaatcatgg ggcctggaaa atgaggcttt
49081 aattgtaaga tgtcctagac aaggaaaacc tagttacacc gtggattggt attactcaca
49141 aacaaacaaa agtattccca ctcaggaaag aaatcgtgtg tttgcctcag gccaacttct
49201 gaagtttcta c-cagctgMag ttgctgattc tggtatttat acctgtattg tcagaaggta
49261 ttatgcagaa ggcNcccatc ttctttcacc ctgctcccct ttcttcagtg gttgattgcc
49321 tgagctgccc ttgctttcat tccttcccta gtcctttctg gaacagttaa atttataaaa
49381 tgatttgaat aaaagtgatt tggataaact tctaggaata ctatcaggtt gaKgtctagc
49441 tcattctgag ctatttggat ttacagttgc agggattgat ttgtagctga cttagagaaa
49501 aacctagctt tcctagtgac caagataact gagagcaatt gcttactttt ggctggaatt
49561 aagaacaaac tagcacagaa aatagtaatc tggatgtttt ccatctcagK gggcctctag
49621 taggtgaaaa ggggcttcta accttcaagt taagccacag aaggctgatg agattgtgtg
49681 cctaaaaatt aattactttt gttcacaaat tgttaaatgt tttgattttg tggctgtatt
49741 tggcacacac aaaatgtcaa atgaattaaa tcaaaaagca ggatgtatta gttaagggcc
49801 taggtctgag actagacaag tgtcaaattc atgctctgcc actagttaac tgtgcgatgc
49861 cagcaagtta cttctctgcc cttcagtttc cttctctgta aaatgcatat aatgtaataa
49921 tatatttcat ctcaaagcat tattgtgaaa ataaactaag gtaatgtgtg aaaagtgctc
49981 atcatcatca ctggtacaga gtaaactctg aataaatagt aattatcttt attacactgg
50041 gattacagca ttacagcaga tgtagtgtat gaataaatgg tgaagaagtc attgttaggg
50101 ctactatggg ggctatgttt ttagctcaag tgtaacaaaa aagtatttaa actctagatt
50161 ttaatgttta tttttaaata ataaaataac cattatgtat attgatggtt tttaagaaga
50221 aaagcaatat taagtaaagg ctgaatttag attaagttat ttcacaatgc taagtgactc
50281 ttttaattgt σtgacttatt ttaacagtcc cacattcaat aggactggat atgcgaatgt
50341 caccatatat aaaaaacaat cagattgcaa tgttccagat tatttgatgt attcaacagt
50401 atctggatca gaaaaaaatt ccaaaattta ttgtcctacc attgacctct acaactggac 50461 agcacctctt gagtggttta aggtaagaag aaatttggaa ggaaatagat gaaaattaca
50521 caattaaaat agacacaagt ggccgggcac agtggctcat gcctgtaatc ctagcacttt
50581 gggaggccaa ggcaggcaga tcacttgagg ccaggagttt gagaccagcc tggccaacat
50641 gaggaaaccc catctctact aaaaatataa aaatcagctg ggtgtggtgg cacacacctg
50701 taatcccagc agcttgggag gctgaggtat gaaaatcact tgaacctaga aggcagaggt
50761 tacagcgagc ccagattgca ccactcactc cagcctaggc aacaaacatt ctgtcaacag
50821 ataaataaat aaaagtgaag aattactgag aaggaaatgg aatttcttat ttcagaattg
50881 tcaggctctt caaggatcaa ggtacagggc gcacaagtca tttttggtca ttgataatgt
50941 gatgactgag gacgcaggtg attacacctg taaatttata cacaatgaaa atggagccaa
51001 ttatagtgtg acggcgacca ggtccttcac ggtcaagggt aagctactga cattaatgag
51061 atagaatact acgtgaaaga agtcgaagtg ggaacagcgg tgcccttctg gttgggtttc
51121 ttgcacttct ccctcctccc tttacttcct cctgctccat cttatcttat acattctgaa
51181 ctatgacgca aagaggtttt ctgaacacac tatcaagatt taagaaattt cagggggaaa
51241 ttacattact aattcaaagc cacatctgtt ctttattctt tYtttgtgac ttaattttcc
51301 aaagataaag caatctgaat gctaacttaa cttacttttt ttgaatggca atacaactat
51361 ttggagagca aaacoagctt tttttttttt tttctagttt ggtgtcagag tttctgcaaa
51421 ttaaaaaaga gcttaatctt tagtaatact cattggattc aaagtYtaat gagaggcttt
51481 gtgatggtat acta-tggtgt acataaatgt tgtcgagtgg tttttaatct ttgtttgcaa
51541 tactttcaac atcatcaatg gccttgagta agtcacttca ttctaaaaat gtgttttcca
51601 agttatttta aattttataa aagcttattt aagggaaaga tttcacaatc atagcttatc
51661 aatctacaaa ggattggggt ctccttagca caagtcgatc tacagacgta gatgtaatag
51721 cccctttacg tatgacagtt ttttcagggc aaagcaatat tggagacaaa tttttggagt
51781 ttttcaatac tccaccgctg taaaataagc atcaccagac cacattccta tcagtgcctc
51841 tttctgttta atatcaaccc ttacagtggt ccttaatcac actgtcatta aataaatgag
51901 catgaaggga tggaggattg cagcagtgct ccataagcac tgcccgtctt tcagccttag
51961 tggtcacagg agtcagaatt ccgtacgggg aagatttcac tgaggatggg ccaccctagt
52021 ggagaactgc gagcaaatct gtggactcat ccatttatta ttttcatggg tcttttgaaa
52081 tcttctctgt agtcttattc ttattctgta gaagagtagt tttctaacaa ctactaggtc
52141 atgtaattag ttttatgggt tggatctgca tttgtttaag tgatatcaga gaataatgat
52201 attaaagagc atcataggta ataaaagaaa gttttattta agtgcctttc tgtttcgtgt
52261 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttt gtcattatgg gttattgtca
52321 gaagaacttg aaaaacattg ctatgaaata gaatagaaac atgaaaatac aagctttata
52381 ttgactagca ttcaatgctc tcctaatatt tatatttctt tttgtcttta agatgagcaa
52441 ggcttttctc tgtttccagt aatcggagcc cctgcacaaa atgaaataaa ggaagtggaa
52501 attggtaaga aaatttatca gaatgctgta aatattgcct ggaaaaatcc ttccatatga
52561 cccctgttct gaattccctt agcaggggtc aggcaattag cataaggaac cttgaggagt
52621 aagtgaggtg acatccctga aagcacctgc cccaagcatt tgctaatatt gggaacaggg
52681 acacagcaat tgcagtgttt acatttgttt attgtacttt gtaattcatg atgctttcat
52741 gtatgcatct aatttcatct tcatctctat cccagagctt gggatggaga cctgcagggt
52801 gttcattctg ggcaatggta gccagatccg gtaaaacatg tttatcttca aagtagctta
52861 tggagagatg aagagagttc tgtagaaaga tgtggaagag ggcagttgga aagaaactct
52921 aatttctagt agagggcaat ccttttacta gaaatccttt gtaatgtggg gttggtgaag
52981 gcagaatcat tggccttgtt agtttcccat gcagatgaga atatagtggg agctgagctt
53041 caaacccagc tgggtgaatg aaggtaatgg aagcagggag gaggcaagag aggacataga
53101 aagaggaagg tgctagagat gagggaggga ggtcctggtg gggtgcatac taagtgttca
53161 gtaaggtttt ttttttacat taaatgggat aaaatgccag tcgcagaagt taattttatt
53221 ggtgaatgtc cttsctcccc tctaggaaaa aacgcaaacc taacttgctc tgcttgtttt
53281 ggaaaaggca ctc-agttctt ggctgccgtc ctgtggcagc ttaatggaac aaaaattaca
53341 gactttggtg aaccaagaat tcaacaagag gaagggcaaa atcaaaggta tttttatatt
53401 gaagagaacc atcctcttcc ccttgcacat ggtttgcacc tgcaaagtag gcattaaaag
53461 taacaggttg ctttcttagt ttcagcaatg ggctggcttg tctagacatg gttttaagaa
53521 tagctgacgt gaaggaagag gatttattgc tgcagtacga ctgtctggcc ctgaatttgc
53581 atggcttgag aaggcacacc gtaagactaa gtaggaaaaa tccaagtaag gagtgtttct
53641 gagactttga tcacz:ctgaac tttctctagc aagtgtaagc agaatggagt gtggttccaa
53701 gagatccatc aagacaatgg gaatggcctg tgccataaaa tgtgcttctc ttcttcRgga
53761 tgttgtttgc tgtctgatct ttgtagactg ttcctgtttg ctgggagctt ctctgctgct
53821 taaattgttc gtcctccccc actccctcct atcgttggtt tgtctagaac actcagctgc
53881 ttctttggtc atccttgttt tctaacttta tgaactccct ctgtgtcact gtatgtgaaa
53941 ggaaatgcac caacaaccgW aaactgaacg tgttcttttg tgctctttta taacttgcat
54001 tacatgttgt aagcatggtc cgttctatac Stttttctgg tcataatgaa cactcatttt
54061 gttagcgagg gtggtaaagt gaacaaaaag gggaagtatc aaactactgc catttcagtg
54121 agaaaatcct aggtgctact ttataataag acatttgtta ggccattctt gcattgatat
54181 aaagaaatac ctgjagactgg gtgatttata tgaaaagagg tttaattggc tcacagttct
54241 gcaggctgta tgggaagcat ggcggcatct gcttctgggg acacctcagg agctttactc
54301 atggcagaag gca-aagcaaa ggcaggcact tcacacagta aaagcaggag cgagagagag 54361 gtgccacact gaaacagcca gatctcatga gaagtcactc actattgcaa ggacagcatc
54421 aaagagatgg tgctaaacca ttcatgatga actcaccccc atgatccaat cacctcccac
54481 caggctccac ctcgaatact ggggattacc attcagcatg agatttgggc aggaacacag
54541 acccaaacca taccacacac attatcattg ttaRactttg taaagtattt aaggtacatg
54601 gaacacacgg gaagtctggt agctcagccc atttctttat tgcatctgtt attcaccatg
54661 taattcaggt accacgtatt ccagggagcc tttcttggcc ctcagtttgc agtatacaca
54721 ctttccaagt actcttgtag catcctgttt gtatcatagc actggtcaca ttgccttacc
54781 taaatctgtt tgacagtctg ctcaacacga ctgcaagctc catgagggca gggacatcat
54841 ctcttccatc tttgggtcct tagtgcaata cctggcagct agccagtgct cagctaaata
54901 tttgttgact gaataaatga atgcacaacc aaattattga taccaaatgt tttttttgtg
54961 tacatttcta cttctctagc tataagtctt aattatacaa caaaatacta tttttatatt
55021 tatgtttggt aaattcaata actt tcctca tcatttggaa agtcaaattg tttattgctt
55081 ccctacagtt ttttctgaat ctagcaggat tttaatgata tcattataat ttgacacaat
55141 aaaaggacaa catgaaactg atgaatcttt attgggttaa tttcagacac tatataatct
55201 tttaaaaatg taacattctt tttt tatat aaataattgg tggcatcaca aatagccaaa
55261 gcagggtgga gagagtgatc cttcctgggt gcaggcaaga aggggatatg ttttctacag
55321 agttttcaaa acagtgataa agctgtctac aagtcattgt gctttttatc atcactatgc
55381 ccagacaatg tgaaacatca gag tgaagt gctcttccca cagaggtgga ctgatccttc
55441 tccccactcc cttggtgtgt ctctgaatgc aatgttgtct tggaaaacag ctttccaagc
55501 atttcactcc tgagcacttg ccagtttcct cacttgttct tcacatatcc aggcaaagac
55561 atcctgtttg ctatatgaag cattgtatcc cgtataaaag gaaggaaaga gagaaatata
55621 tttttacact catcactcct caggggctgt acaatcatgt agaaattgtt taatgtgcYt
55681 gtcaaatagc caaagagtgt taaaccctga gttcccaccc atgtgtgtgg tatggttagg
55741 attcatccag atacacagag agaggcacaa caggaggaga aaggataggg gtgtggggac
55801 agcgggcccc caatatggtg taat cgtggc aggtctctgc ctgaagtgct atgtggggtt
55861 tttcttgttt taattttgac tttaacccct gatttgtaag tttttcataa aataaacaga
55921 atcataactc atgtagatgg ctat agtgc cgtagtgttc tgtgggtctc tggtgtctgc
55981 cagtgataag tgtggcaccc caggaaggct gtggacccca tcaaggtgct atgtgagggc
56041 catgcttggg gtggtggtgg gcccagtaga ccctgcagcc atccatccag cctgcccacY
56101 cacactgccc ttgtgtactc ctgctttgct acgttatcat tgatcaatgt ccctggttac
56161 ctatgtgttt gaattatctt cRtgttacag gtgtttaatg attttgctcc ttctagctta
56221 tttgtatttc acctgttttt ctttaaatca acatggttac actctgtttc agcaactgta
56281 taaattaaac acaaattatt actactgcta ttgagttgtc atgatgaatt cttttttatt
56341 tctgaaatta tagcatttct tgaatttaag agaacaaaaa cttgaaaggc ctatgtctcc
56401 attttattaa ctattactaa atacatattt gatgctcata ataataatac acatttattc
56461 attatttcct atgtacaagg actcatctgc ttattttaca tttaactttc tcatttattt
56521 tctcaatact tcaaagtaaa agacaaagaa agttgaataa cttgcgaaat actacagtta
56581 tggagcaagg attcaaacac agccagcatt ttcctagcta tatgtgtata cagaaagtaa
56641 tgttttgtca tcacatacct gaattactta tacttttata aaataattca cacttacgaa
56701 gacttcctct gatgtcttgg atcaacttct ttcctctact tggaagcgtc cagccaatgg
56761 catggttact tcccagcaat ccccacagga agtacacatt cctctgtgca tccagctggg
56821 gattttagag agagagtgac ctggaaagga atcctgttga aatgatttac ttacggagtt
56881 ttcattattt aacctgatga cagtaagctc tttgtcaatt ttcacttttt ccccccaatt
56941 ttgtgtcaca tcaccttgat aattcttgat tccatactgc tggtcattga gagaactgat
57001 aaactattag aggttgtgga ggaattcgtg aatatgggcc agtgattttt ctaccttaaa
57061 actgggagcc catgcatgga gacttaagac ggaaaagaac cgtatcagca aatctcattt
57121 gagattcttc tcacattcat cagtgcatat gcatgttgca tctacatttt gtgaagcaag
57181 gagtactagg aaaaatttct gggttggttg agtaatgttc accatgagag aagtatgggc
57241 tatgagtagg acctagaact tagtaatttg acttttgaat tctttatcaa agacgcttta
57301 gccacttagg tgactcttgc ttcttctcct acctcccaca ctgctaagcc cttagaggca
57361 acaagtgtct cagacccgtt gatgccttct ccttaatgcc ctgacagcac cttgtccgtt
57421 cctttctcat tattgcatga gttacaaccc tctgcatctt gcaacccaag taccacactc
57481 cattcttctc tgagtgccca tagtttcttt ccacagaaac aaactttctg ctaccatcag
57541 attaatctct tgggaaaacc actcaagtct ccagtgctcc tgtgaccttc agaataaggc
57601 aatctgcctt agttggggtt tcaagtctgg acagaacctg gccctgacca aactttctaa
57661 tcatatcttc caccaattcc ccaaactggg ttattccatt tcctcagaaa acacacttcc
57721 tctctgcact taggcttatg gtattctctc tgcccaggtg ggcatttcct tttttgcatc
57781 tccctgaatc ctactcatct ttcagaggcc tcctcctcct ccaggaaggc tccctttccc
57841 agtcctgcat ggagcaagct ctccttctaa actcctctgc cagcaaaaat catgcttttg
57901 cctcccatct tagttaagtt gacaagtgtc tctctgcctc ttttgccttt gagaatgccc
57961 tataatgctt agcctgatgt gttgtagagg ctcaataaat gtgactgtcc tggtacttaa
58021 agcagccatg aaaattccca gtgggtatat cttatgtgaa attcttgtac tcccaaggga
58081 agccaacatc catgtatcag tttattatat cttgtttcag tagtaataat aatctttttc
58141 tttcttttga atagttgatc atcatagcat ctactgcata attgcagtat gtagtgtatt
58201 tttaatgcta atcaatgtcc tggttatcat cctaaaaatg ttctggattg aggccactct 58261 gctctggaga gacatagcta aaccttacaa gactsggaat ggtaagtggc aaataccaag 58321 tttttctccc aaagaaaaag tcccataata actgttggtt acctgtctat taatctttca 58381 gtagctaggc tgctaagccc agattccatt ttgcttgcta atctgttatc agtgagttgt 58441 gtttttggat tttcttaaag gccattttcc atcctgctat gtaaatcctc acggtcctga 58501 gatccatctc aacagctcac ttttcttccc cgataggatt gctattccta ctgagttccc 58561 aataacagaa tctgccccaa gcccagaaag gtgtsaattt cataatgtat cggtaagaca 58621 ttatgaagtt aaacacagta gcaaaattgt tcctgttttc cagatgtgag caggttagaa 58681 aggtccatcg gaatgcatgt gtgttctacc tgaaεaccctg atctgtaaag tctaacccag 58741 gcacacaagc atgtgcatga aaggagtcag ttctgcctgc tagatgcaaa cttcatgctt 58801 acatttggag gcagatacat gttgcatttt tcaaacagtt gactgaagta ggagctcatt 58861 gtttgatctg tggaaaattc agatccctta aaaaattcta tgcccttgct actattagct 58921 ttaaattttt tcacttcccc aggggagtat ggggsaacca aagatgaaac caaagtctat 58981 tcagcacaga aggccccctt agtcatagat tattεaatcaa aattgatgag atggacaggt 59041 tcttgtccac ttttttgtta tttagtctgt gacagtaaaa aggagaaaca ctttgggatg 59101 aagactgtta tttcctgata gtgttttgtg gcagtggttt gacgtcaaca tctcttgagt 59161 ctagaatatt ttggaggatg acatacattc accascagcc ataaaacttg gagaggaatg 59221 tcttcaaaga gtccagtgag aatttttaga atcaagtaag aagttgtact tcttgttttc 59281 attttcagat ggaaagctct atgatgctta tgttgtctac ccacggaact acaaatccag 59341 tacagatggg gccagtcgtg tagagcactt tgttcaccag attctgcctg atgttcttga 59401 aaataaatgt ggctatacct tatgcattta tgggagagat atgctacctg gagaaggtaa 59461 agctattgac atacattagg gacagaaatt catgcttatt aaaggctgtg aactaggtgg 59521 ccttatccct gcattggata atgaattgca tttac-tacca caggccttaa gaccagaact 59581 ttaaatattt atccagaagc agacacttat ccttcaatcg cccctctccc atcattgtcc 59641 tggtgatgag atcttcacag taatgttggt ggtgtgaatt cagagttaga agtcctttgc 59701 ttcaaggact tagcaaacca tcatccctac tttattccct tggtccccca ccaggataac 59761 tctgccactt cttaattctg tccataagat ttgaaagagg acttaaaaat tgatgaRttt 59821 tgttctggta gccataggca ctagctgaaa taccttaaaa gtactcagag agtcttcatg 59881 actttcttta tgttggtgaa acatttgcaa atttatattc tcaccagaac aaaaagaact 59941 atagcttctg ttccttaata ttcctaccca attttatata cttttgacag ttttatcaca 60001 actcctgtgt ttgcagtagt tatttttccc ttcccttcat acatttatgt ccagtacctg 60061 tggaccctcc ttgtgaactc ttctctaatt tctcacagac caggaagggt ttggaatata 60121 actggggctc agctatcaag ggcctaagca taatsaagta aatgttcagt tttacatttt 60181 aaactcattt tactaagaag aggaattcac atgcctatag atgtaaaggt atgaacaaca 60241 ggtgactttg gtttaccctg gaatatctgg gaatgctaat agcctcaata acggctcaag 60301 agacttgtga aagatacaat ttaggagaat ctaatgcatt tcttctctca aggctctctt 60361 cttcccccat tttcccactg gccacccatg caggtagaag taatgagtaa tgctctcaaa 60421 cactcttttc atattacaaa tgtactcaag aacctgcagg gactcctgtt gtttgtgagc 60481 tcaacaatgt gccacatctg gccacaagct cttcacctct tctttttcag tcYatccacc 60541 taagttctag ttacacttct cctcagccaa acccsgatgc tagctctctc acactcaagc 60601 ttgtgctgcc ttcaatgtgt gacaacatac taatctggaa tggttttcta cttccYtctg 60661 tcaatgcatg tcctctgacc tttcctcaac caaaataaat gaaacccaac aacaccaaac 60721 ttcactcttc acttaggaaa gttcatgact gactεaaggta ctgtctatag tctcatgcaa 60781 cttaccttgc atttgcccca tcaaaatcct ctctgcacca ccattccatc cagtggccct 60841 gggtggctga tcatcatgga atccattgca cccttgtcct ctgctccagg ctgggtttgg 60901 ccaatgggag gcactggcag gaggtcagag ggtggtcatg tacctgcctc tccacgtggg 60961 gcttctggag cagctgtgct tctccttctg ggagcacctc ttctcagctg gcctgcctca 61021 tgcatctgca atccctcaga cacccgtctg tgagsatatc ttggattgtt ttattcacgg 61081 ttgtgctttc tcctgttgca gtgaggactg ggtatttcat gttctttctg agtccaccca 61141 gagctaattg gaatcaccat ggtgtctacg ctgtataaat gccaaatggg aaaggggatc 61201 tattgtccct tgagattttt ctagtttgga tcaastcagt ttctacaaca gagattaatg 61261 ggggtgaagt aaagtcagga cttactttcc tagagacttt ggacaatttt gaggggcaaa 61321 gcttcctgag tttgtgattt ttaatatgtg agttaaaatt ttaagccatt gaaaaacata 61381 taagcaaata ttctaagaag ataatatgta ttctaagaag aatgaaccag aattctaagt 61441 ctctaatgca acaatagact aaatatcttt acattcccat ttacttggaa ggactctgtt 61501 ttagttaaga ctaagctacc tgggaaataa aaagaggaca ttggggctga tattctcaca 61561 aatgaaagga acacaaagaa caaaacgggt tctctatcca cacatacttc cacttctctg 61621 agtaagtgac ttgatgtcag agaatctcac accagattat aacaataaga cttttaaatg 61681 ttcaggatgt ttatgtttaa agcattagac tgataagaaa tctgatctat ttcttgtatg 61741 actagatgta gtcactgcag tggaaaccaa catacgaaag agcaggcggc acattttcat 61801 cctgacccct cagatcactc acaataagga gtttgcctac gagcaggagg ttgccctgca 61861 ctgtgccctc atccagaacg acgccaaggt gatac-ttatt gagatggagg ctctgagcga 61921 gctggacatg ctgcaggctg aggcgcttca ggactccctc cagcatctta tgaaagtaca 61981 ggggaccatc aagtggaggg aggaccacat tgccaataaa aggtccctga attctaaatt 62041 ctggaagcac gtgaggtacc aaatgcctgt gccaagcaaa attcccagaa aggcctctag 62101 tttgactccc ttggctgccc agaagcaata gtgcc:tgctg tgatgtgcaa aggcatctga 62161 gtttgaagct ttcctgactt ctcctagctg gcttatgccc ctgcactgaa gtgtgaggag
62221 caggaatatt aaagggattc aggcctcagg tttcatctgg taactttcct tccatttccc
62281 tgcttctggg tggatgcaaa atggccagaa atttttctcc tcaatcctcc accatcctcc
62341 agccaccatt ttcttccctt ttcccttttg cttgcctgtc ttcactgtgg tgtgggatgt
62401 tttcactact cttttttcct ctctctctgt cttgctttgt ttctcctcat tcttgtcaat
62461 aatctgaata gcaaactaat cattcgagag tagattttca cgtcacttga agaacattct
62521 gattccctca ggcagaatgt cagttgtaaa tcttgttccc aacatgccag attttcttta
62581 ttttctatat atatatataa tattttatat ataatattat atataatatt ttatatataa
62641 ttttatatat aaaatattat atataatatt atatataata ttttctatat aaaatgtgta
62701 tataattata tataattata taaaatataa tatagaatat ctaataatgt ataatatata
62761 acatataaaa ataatattat ttaatatata atattttata tataatattt ttatatataa
62821 tataatatat attttatata taattattaa ttatataatt aatatataat atatatttta
62881 tacataatta ttaattatat ataattaata tataatatat cttatacata attatcaatt
62941 atatataatt aatatataat atatatttta tacataatta ttaattatat ataattaata
63001 tataatatat cttatacata atatatataa atatattata tataatatat attatatata
63061 atattatata taatatatat tatatatata aaa ttatat ataatattat atataatatt
63121 atatatttta tatacaatat gatatataat ataatttata tattatatat atttatatat
63181 aattattata taaattatat aaatataaat tat tattta tatataatta ttatataaat
63241 cattatataa ttattataat tataatatat aat ataatat aatattatat ataatatata
63301 gtattctata taaataatat aacatatatt tta tatagaa tattatatat aatataatat
63361 atattttata tagaatatta tatataatat aat atatatt ttatatagaa tattttatat
63421 atataatatt atatatatgt atttgagaca gag tctccta tgaacatact tgtggactta
63481 tgattttatt ttgacactta agagtggtca tagggtaggt gcatatttaa ctttcagaga
63541 aacttataca ttgtttcgca aactaattgt act actttac attcccacca gttgtgtatg
63601 agagctctgc tgcttcattg cctcaccaat aat tggtgtt gtcaagtttc tttatatttt
63661 aacaattttc acaggtgtta gatgaagatc accatggtct taacttgaag ttccccgact
63721 catgatgatg agcccttttc atgttttcat tg ccattcg tatatatttt ttagtgaagg
63781 caaaatattt tgccttattt aaattgtatt tct ttttata ttgttgatgt gtaggaatta
63841 tttatgtatt gtggatgcaa gttctttgcc aga tagatgt aaagtgagaa tatttccagg
63901 gttatctatt catttttaag tgatgtcttt gtt tagtaga catttttaat tttggtgatg
63961 tccaattaat caatgtgtcc caaatggcta ttt ttttttg tgtcctagct aagaattttt
64021 tttttttgcc tgtccaagag catgatttat ttatttattt tttgcctgtt caagggtctt
64081 ctctgtattt ttatgaaata tttacggttc tag-cttttat gtttaggtcc atggtctatt
64141 gtgaattgat acttgtatat agaacaaggc aaggacaaag ttcttttttc tgctgctgct
64201 tcttctgtag aggtacccag ctgttccagc aatgtttgtg aaagactgtt ttttccccac
64261 tgaattgaca tggtgctttg ttaaaaaaat caattgacta gatatgtgtg gatctattag
64321 tctactttct attttgtatg tttgtatgtt tctgtgaata tcacattgcc ataattacta
64381 ttgccttatt ataaatcctc aagtcagtat aagtctctca actttgttca tctttgtcaa
64441 gattgcccag acaggccggg caggtggctc acc-cctgtaa tttcaacact ttgggaggct
64501 gaaatgggtg gatcacctga ggtcgagagt tcaaaaccag cctgaccaac acggagaaac
64561 cctgtctcta ctaaaaatac aaaagtagcc aggjcgtgata gtgcatgcct gtaatcccag
64621 ctactcgggc ggctgaggca ggagaatcgc ttcjaacccgg gaggcggagg ttgcagtgag
64681 ccgagatcgc gtcattgcac tcactccagc ctgggcaaga agagcaaaac tccgtctctg
64741 tccggacaat cctagattat ttgcattttc atatgaattt tagaaacagc ttcttaattt
64801 ctttgaaaaa ttttcctggg atttggattg aattgtatta aatatataga ttctgtaata
64861 tatagagtct aaaaatatac agtgtggaga atagatgtct taagtcttcc aatccgtaaa
64921 cgtggtatat ccctttatta cttagatgtt tcatctctgt tagcaatatt ttgtagtttt
64981 cacaggagat atctcatata ttatccaatg aatttatact ttggtatttt gatttttaaa
65041 tgctatggta aatggcattt ttaacaaact tcacttttca agtttccatc tctaatatat
65101 agaattgcta ttgattttta tattccatga tcttgataaa cttaatattt ccagtagttt
65161 ttttttttgt agatttcaaa agttggtcta catataatta tgctctctgt taaaaccagt
65221 agttttaatt ctttcttctc aatctttatg ctttctaatt ttatttttat ttcttcactt
65281 gttgcaaagc agttgtccca ggtgggagcc aaaatcctta tctcattact aatcttagga
65341 aaaagtaaaa tgtttcacta ttatgaggtc acctgtaggt ttcttataga tgttctttat
65401 cagattaaga aagatcattt ctactctcgg ttttctgatc gttattaatt cagaaagggt
65461 gttgaatttt gccagatgct tttatttgca tttattgaga taattacata tttttattta
65521 ttatgtggtg aattatctaa attgggtaaa aagaattaaa atcattgtcc aattgaacat
65581 tttgcctgtc ggctatgggt ttcccttttc ctttggttaa ataacagttc tgccacaaaa
65641 taaaaatcta gaaacacaca ttcccctttg gcctccttaa aaaaaattaa aacttcaaca
65701 attgcacccc tctctattac ttccctatag tgsactccca tccttctggg aaagcaaaaa
65761 gcctggggcg catttgtgta cttgagacgc ggsgcccctc tcaccttcgg catcccccgg
65821 ggacccctct tccaccctca gccctcccct cctcttcctc tgaagagccg ggcggccgct
65881 gcggccagcg gtcctccctc ctggcatcct ctgctgtgaa ccgcggcctg cagggtgctt
65941 gcgagcggcc cgggcgcgcc cccttccggc cccgcaggtc acccggctac agcccgggtt
66001 ttcccgggac ccgcgccgcg cggctgggca ggεaagcgcca gacgcctggg gcccacgccg 66061 tccgcgggaa aagggcaagg cgctgggttt tccagcagca acctttggac cccgcgatcc
66121 agtagctccg gtaactccac gcggggcgtc tgggtggagg agccggrtcct ggagcacggc
66181 tgcgaggagc acccggaccg gagggtcccc agaccgggac ctccga-gtca gggaggattc
66241 tacgccaggg agcgccccag actgagagcg ccccagaccg ctacac-tccc ggacccggag
66301 cttcgcccga ccgcgggcag tgcccacctg cagcctccac cggccgrgggt tagcagccag
66361 gagctgccag acgcctgaca ttcttctttc tgttcctact ttttttcctt cttcttcttt
66421 tttttttttt ttgtagccct ctctgggtgc cttatctctt taatca-cacc tctctttcac
66481 tttccacggt agtcaggagg cggagatcgc tgcttctcac ctactttctg aacttggcct
66541 ccgcagtcgc gacctggcgt gaaggaggag ctgccgcccc cgcccc-agcc tcggggacgc
66601 ctctctgaag gtaagggtgg gctccgctgc cacccgcatc ccctcc-ccac cccccagagg
66661 aagggaagac caccatccgg ggagggattc tcaaaacaag atcaat taag agagagagag
66721 agatagtgtg tgtgtgaata cgtgtgaata attgatgaga cagcatcctg tctttctctg
66781 aaagtatagt tttagaaatt aagacatccc caattatttt ctggagraggt gagaacgact
66841 gaaataaatg ataacaatag ttgtcatttt ttaagtgctt actgtgrtgcc tgacactgta
66901 gaaaattttt agatatctta ttttcactta atcctcctaa gggcca-catg aaataggaac
66961 tattattatg ctttaataaa agggaggagg aattccgtca tttacccaag agtatccagc
67021 tactaagtag tagatcccag atccacacct acagtttttc tgattccaga gcctttgtct
67081 tttttctgcc cagccttggg aagttaaaat gcccagcacc ttgcatcgca gttatcagac
67141 aaattaatga ggtgtcaatt gcagccagat acagagatcc aagattattg tattcatttc
67201 actgacttcc cttgcttcat tctcaagacc ctttgcaaat actgattttg tgtcatacac
67261 agtgctgcta ttgggagcac acctctcaac ctcagggcct tggatgrggct aggaggggta
67321 aatttgggga attgggtttg tgcaggttct ggggacagtg ttttc ctct cσctgcacaa
67381 atatacatcc aaaggctgag aactaaggct aaggcctagg aatgtgrgatt gaaaaggcag
67441 ggtctaaatc ccagcacttg ggaggctgag gtgggcggat catgagrgtca ggagatcgag
67501 accatcctgg ctaacatggt gaaaccccgt ctctactaaa aataca-gaaa attagccagg
67561 catggtggca tgcatctgta atcccagcta ctcgggaggc tgaggσagga gaatcccttg
67621 aacctgggag gcagaggttg cagtgagcag agattgtgcc actgcactcc agcctgggcg
67681 acagagtgag actctatctc aaaaaaaaaa aagaaaaaaa agaaaa-ggca gggtccctgc
67741 cttcagggac ctcaccagag agtgggagct agtccaggag tgatggraaac acctgcagag
67801 tgatggagac gggcttggac ataggcatgt gccatttggg gctgttgcag ttggagagct
67861 tccttgagaa ggcaaatact gagccaagtt gaaaggactc taggga-cctg gcatctggga
67921 taagtgggga gggtggccca ggtagcacag gcataggcag atttggrgggg aagcataagg
67981 ctaacaacag acacttgtgt gacaaggact atgaggtggc attgat tttc ttggccttac
68041 agatgagaag ccagattcca cacaaattat tttgtttgtt agagtt taag cgtgtgtgtg
68101 tgtgtgtatg ttatgcccca agatcatttt ctcσtctttg catttgrgttg ttttatcatc
68161 tcacaggctg agtaaaacga ctatgcatgg aacactgtag aagaaa-aatt atattaaaaa
68221 aaaactggtg ttatgatttt catccaggca ttttgtctca ggagttgctc gattgtatgt
68281 gttgctaatg agtgatttat attgaggcat ctacattgat tcatgtgtgt ccttgtgaat
68341 agctgtaatc tgaggctggc catttcactt cctcaaatct caggtt cctc attagaaaga
68401 gctttgaaat ggctctttcc ctgtacatta tgtgtttctg tgaatt actt ttagagaaag
68461 gtcagtttct cagggtggga cccataaaca agggcaactg ggcagagcca ggggttcagg
68521 tgactgtttg gaccctctgg aagggctttt tactgtgctg ccttggrgaga cagagtggtc
68581 agcttggaac tgaccttaag cctaggtcac ccaatttttg aaggaa-actt ttttttttca
68641 tttagagaaa acttcatgcc tttgggtgat taggtaagtt tgtgactatt cgttatgtgt
68701 gtgtacacac acgtacgtac atatgtacat gcacaaatat ttaatatgtc ttagacacac
68761 caaatatatg catttaagat gtattaaatg tactttcctg agaata-caaa taagtgccct
68821 acgtcggcgg ctctcttcct gactgtatgt tagagtcacc tgcggagttc tgaggactca
68881 agatgcccag tctgtcctcc agaccactgg gtggagcccg ggcatcatta tttttttcca
68941 aacttgggtg agagctggtg gcctagactt cacattagtt gctaaaacat actttccaag
69001 atatcatgcg ttaaaaagca tttcaaaagt agattgtgca gatgtgrccaa tggatcagat
69061 gatcacctag attcaaaatt atgtatattt tatggatgta attcat tcaa taattcagca
69121 aataacaaag aaacaagcag acataaagtg aaaatatgac agttagrtgat aagtgctatg
69181 aatagaaaaa ctaaacatgg gagggtagag gaacattggt gtgtgtgagc atgtgtgtgt
69241 gtgtgcgtgt gtgtgcatgt gcatgtttgc atttggaaaa gcatgc tgtg ctagacttgc
69301 agtagagtgc tcagggagga cctgtacatt ataagctagt gtcagcaaac cgtaggggaa
69361 atacaggatt atttaattaa caatagagaa gtaattagta ggtatt tgag gaaagtaagt
69421 ttagttactc cctatcttca tgtcaatcaa gaaaattaat tgttggrtgga tgaaaaaagt
69481 taaatataaa aacaaaacaa aacaatactg agccataaaa atgaagraaac tatgtaagca
69541 tctatttgac caccaacagg aaaggatatt ctacacttaa aagcaa-tgaa aacatctcaa
69601 agcaaaagaa tgatcggttt gactacatca atataaaatt tgtcat atat tagcataaca
69661 aaagagagaa agtaaacaac aagttagaca aacatctgag aactggracaa aagacataaa
69721 gagatggttc ataaacatga aaataaaatg gctgataata agtgat taat atttgcctca
69781 tttataccca aagaaatgca aattcagaaa acaatgagat accatt tttc cattttggct
69841 gtctaattac attttaaaag taaagctgct cagtgtgctt ctgggtgtgg tcgatagatg
69901 ctgtcttgtg ctattgagtg agagaatatg aatattgcaa cacttctgga atgcagtttg 69961 tcagcatgca tctgtcaggt ttcaatgtag tcttcaactc aatcactgta ctgccatcga
70021 gtaacatcca ggaaataata agaaatgtag acaaataata at-agctaaca tttaagcggt
70081 attaccattc accagacact tgcaatagta actcatttaa ctttcacatc agttccagga
70141 gatggtatta ttatcccctt ctatagataa gaaaattgag gc-acagaaca ggcaagtcag
70201 ttgcccacag tcggttagct ggttgaaggt agaatggaga ttcaaatcca cccaggctgc
70261 cacctgagcc catcctgcaa aaaaactgag ccatcctggc tt-acctgtga agatggtcat
70321 gtgattatct cataatacat ctggtaaatg ataatatatc cat atgaagt aatattaggt
70381 ggcaattaga atggttttaa caaagagttt tgtgacacag ga-aaaatgct cattatgtaa
70441 tattaggtgg aaatgcagga tatgcaatct tttaaacatc ttttattttt tgagaaggag
70501 tcttgctctg tcacctaggc tggagtgcag tgatgagatc tcggctcact gcaagctccg
70561 cctcccggat tcacaccatt ctcctgcctc atcctcctta gt-agctggga ctacaggtgc
70621 ctgccaacgt gcctggctaa ttttttgtat ttttagtaga gacggggttt caccatgtta
70681 gtcaggatgg tctcagtctc ctgacctcat gatccgccca tctcggcctc ccaaagtgct
70741 gggattacag gcatgagcca ctgtgcccgg ccaaacatct ta-attatgtg acaacattta
70801 taaaaagtac aagaaaacat gttaaaatat tatacatgtt gagattattt tcttctttca
70861 gtcttcattt tgtaaatctc ctacattgag tgtaaattgc tttggaaatc agaaaaactt
70921 taaaaagaaa gaaacttaag agttacggaa aagcaaaaat attgatgtta aacataacaa
70981 ttaaaaaccc ttaaaattct tacatgtgag acatttaata tttatattct tctatgccta
71041 ttttattaat acttgctaga gtatctgtta catttatcag aa-fcatctctt tttctggaaa
71101 tgaattcatt atttaatata accttaatct gttaaattca cacataaaac ttaagtacat
71161 taaaaatttt acatacacac atccacattt gcagaatggt gtgcaaatac cagctaattt
71221 ttgtatactg agatcttaat atgtttcata ttgaaactca gagttaactt gtcagtttgc
71281 tgagccatct cctgataact ttgtctcttg gtagatattg aatatttttt ttaaagtggt
71341 gctttttata aggttacatc agtcttaatc agagtgacat aa-aggaaata acatttttta
71401 ttctatccaa gataaaagaa taggcagagt taataataaa atgtgtgtgg aggtagtggg
71461 ggaggtttca aaccatagac ccagtctaat ttgattatgc acagttggta ctttccattc
71521 atacttgttt ctttggcctt tacattattg attattatct ct-fcggaaatt ccaccaaata
71581 tttggtgatt tttccataag gatgtatgtg aatggtttgg cagcttagcc attaagcttt
71641 atcctggatt caggcattga caactctgtt tttaggatgg aagatgagta gttgttggtg
71701 agaggggcat tattctgagc tgagaagctg ccatgcactc aggaagtctc cataagcctt
71761 agatggttta atcactcaat aattccagaa acaggccttc ttatcatctc cattttggta
71821 atgaccaaat aggctctaag acttgctcaa gttttgcaca gcttgtcagg actcaaactg
71881 gagtggcagc ccaggtttgt gtgtttctga aaccagactc tgeccatcagg ctgtgctccc
71941 tgcactcagg atggtaaaca agggatatgg tgttgtttat gc-agtattta gactctgaat
72001 ggtctccact gtgggggatc cttcctccac tgggctcaaa gttgtaatca gaactccgaa
72061 tgctaggttg cagtaggatc aaagttcaat gcagatctta gttccactgg gacacagtca
72121 atgtaaagga ggggtctgga gtgtaggaga ctgtcacttc ate tctccat ttccctaaag
72181 taaactcata tgggcagcca cagacacaYg cgaacacatg catacacacc tatgcctcag
72241 tgacacatgt tagtgagtgc tggccatgtg ctaggcatcg tgcctggattt tagtgataca
72301 gtgaagagca aaatagactt agtgcctaga attatgaaag aattatgaaa cctacgttct
72361 gaaggaggaa gatggagttt taaaaattca accctaaatg aagatctcat tacaattcag
72421 gaatgttttg atgtgaaaac acacacacac actctgttac atgggcagaa ctgccataca
72481 tagctcagca tgtcacagat tgtttattca tagaatggta atatttgtag cagtactatt
72541 gttctgaact ttggccttgg aagcaggatt tagtagacca ggccctgaaat tcttcagact
72601 ctgttgtatc agagaaataa attattaggg atttcttcca gaagaaaaac ttcattgcct
72661 tgaaatttta ttaattttat atggctgaaa gttctgagaa ttggttacta tattaaggat
72721 tataaaaatc ttctaggttg tttttttaaa aatctgtgtg ccagaagatt tttaaacYtt
72781 cataagatag gcacactttt gtttgaaagc tttggctgaa tctgttttat tctgttttcc
72841 agagaagcca tttgaagcag aatccaaacc atgaattgta gagaattacc cttgaccctt
72901 tgggtgctta tatctgtaag cactgcaggt aagtgattat ac-atactctc aaacatattt
72961 catgagtaat tgaggaagaa tgtcaaagtt ttttttttta tgtggtggct actgaagatg
73021 ctgaatttat tcagaaaaga aaagattctg cagtctgagt tc-atgtagtg agagcagagt
73081 gaaaaacttg catcttgaaa taaattacat ttgtctgagg tg-aaaattta tttcatgtta
73141 tttgaaactg aggaggtggc agccatcttt attattgggt tt taggaagt ttgaaacaca
73201 ctttctcctt cctgagaggg aggcaaagat tcatctcatt atttaggtaa taatgagaaa
73261 agtaaacgac aaatatatta gacagcttaa aaaaattaga gtgagacaga atatacaaaa
73321 aagagactgg ctagaccaag gagctcaagt aggcttcata gt-agatgtca aatgccaatt
73381 ttaatttatt agcagtgatt gcctagagtt tttttttttt at"ttgagaag gattctgaga
73441 cttcattctt tagcgttcca tgattgaata gcaaggcatt cc-fctaggctt tgggggagaa
73501 agtgggagca caaatattaa tttgccttga tctattatct aggagaggga aacacatggg
73561 ctcatttccc tactttgata attactgctg aagagatagc tg-aattaagc ttttggtact
73621 ttcaaataac acaggtccaa tctcagggta tatttactta cg-fcgaatcca tttattattg
73681 agatccctgc aatggaaccc tacccagatg ataaaagaat gaggtagatc ttcatttttt
73741 tatatgtaat gatctgtcaa acaagtgagt ggaaaagcaa ggtacaggaa aatgtgtcat
73801 gagttccatg tcctgtggac atacactaat agccttactc ctcattataa tgagagcatg 73861 tttcaggcac agaaacagcc atgcagccag ttgtgcaaag ttgccaagct cccagctgcc 73921 tgccctgaag agcacttttc atgaatgttt cactctaggg agacatgaca atgttctaca 73981 tgtaggattc actgaaccta gttgagttta aatgacaaaa tgctatgatt gtccaaactc 74041 aagacagttt caaacacaga ctttattcca aagggcattg gttgt tggca ctgctgggtt 74101 cttatactgt gtttatggaa caataggagt gcctattttg gcact tggaa ctccacaaac 74161 cttgaattcc acttatttat cccatcaagg accatttcca acaagcatta tggtaatcaa 74221 caaagcctct aatggtaaac catgattaga tatccaaagc ttctagctgc ctgaggaggg 74281 gggtggtgtg gaStttcaat tatcaacctc ccacctctgg agagtgtgta attcacatta 74341 agtttcttca aatggtaata cttccagaga gcacatgtcc atccaaacac agtcatatgt 74401 gtttatagaa gctttttaag acaagcgaaa acctgaaaac ctagaaataa gccaatatcc 74461 aacagacatt tgtttaataa accaaatccc caacatgcat ccttttataa aatggataaa 74521 ttgcgaaatg gtaacacgat tagatactac attacaatga gaaaagaaca catcactgct 74581 acagcatgaa tgcatttata acaatcatgt caaaataacc cagacataaa ggagcacata 74641 ttgtatagcc tatgcatttt attatattaa ctctaaaaca ggaaaataaa tgaactgtta 74701 atgactcacc agggttttgc atgtcaattg aagctgacac ccacatatac acatgtatca
74761 caccttctat gttgaagtat tagtataaaa tagagattgt attgcaacca gaaaacatga 74821 agttggtgct ccttaactct tgtgttttgt ggtagattcg acatccatgt tttcaaagaa 74881 tgtgtattag tccattctca tgctgctaat aaaggcatac ttgagactgg gtaatttata 74941 aaggaaagag actttattga ttcacagttc tgtatggctg gggaggcctc aggaagctta 75001 caatcatagt ggaaggggaa gaaaacatat ccttcttcac atggtggcat caaggagaag 75061 gctgagcaaa aaggggaaaa gccccttata aaaacatcag atcttatgag aactcactca 75121 ctatcaggag cacagcatga gggtaatcac ccccatgatt aaattacctt ccaccaggtc 75181 cctcctatga cacatggggc ttatgggaac tacaattcaa gatgatttgg gttggggtat 75241 agccaaatca tatcattcca cccctggcct ctcccaaatc tcatgctctc acatttcaaa 75301 acacaatcat gcccttctaa cagtccccca aagtcttcac tcattccagc attaactcta
75361 aaatccaagt ccaaagtctc atctgagaca aggaaggtcc cttcctatga gtcagtaaat 75421 tcaagagcaa tttagttact tcctagatac aatgggagta caggcattga gtaaatacac
75481 cccttccaaa tgggagaaat tgactaaaac aaaggggcta ctggccccat gcaagttcta 75541 aatttaatag ggcagtcatt aaaccttaaa gttccaaaat agtctccttc aactccatgt 75601 ctcatatcca ggtcacgctg ctgcaagagg taggatccca tggccttggg cagctatgct 75661 cctgtggctt tgcagggtac atctttcttc ctggtttctt tcatgggctg gtgttgagtt 75721 tctgggcttt ttcaagtgca tggtgcaagc tgtcagtgaa tctatcatcc tggggcctgg 75781 aggatggtgg ctttcttctc ttaactccac tagctgtact ccagtgggga ctctgtatgg 75841 gagccccaac accacatttc ccttccacac taccctagca aagattctac atgagggttc 75901 cacccctgca gcaaactttt gcctggacat ccagcatttc catacatcct ctgaaaccta 75961 ggcgtaggtt cccaaacctc aattcttgac ttttgtgcac ctgcagcctc aacaccatgt 76021 ggaagctgcc aaggtttggg gcttgcaccc tctgaagcca cagcctgacc tggtatcttg 76081 gcctgtttta gcaatggctg gaggggtagg atgcagggca ccaaatccct aggctgcaca 76141 cagaaaggga ccctgggccc atcccaggaa atcatttttt cctcttaggc ctctgggcct 76201 gtgatgggag ggtctctcat gaagatctct gacataccct agaggcattt ttccccttgt 76261 cttggcaatt aacatttgag tcctcatttc ttatgcaaat ttctgcaacc agctttaatt 76321 ccatgccccc cattcccacg aacatggatt tttctctcct accacattct caagctgtga 76381 attttccaaa ctcttatgct ctgtcacctc ttgaatgatt tgctctttag aaatttcttc 76441 ttccagataa tcgtctctca agttcaaagt tccatagatc tctaggacaa gggcaaaatg 76501 caactaatct ctttgctaaa cataacaaga ttcacttttg ctccagctcc ccaaaagttc 76561 ctcatctcca tctgagacca cctcagcctg gactttattg tccataacat tatcagcatt 76621 ttggttaaag ccatttaaca agtctttagg aagttccaaa cttttccata ttttcttatc 76681 ttcttcaaac tgttccaact gttccaaact gccctccaaa ctgttcccaac ctctgcctgt 76741 atgcagttcc aaagtcactt ccacattttg tgtatcttta cagtagcacc ccacttctgg 76801 taccaattta ctttattagt ccattctcac actgctaata aaggcatacc tgagaccagg 76861 taatatataa aggagaaaga tttaatggac tcagttctgc agggctgggg aggcctcagg 76921 aaacttacaa aagggggaaa agccccttac aaaaccatca gatctcatga gaactcactc 76981 actatcatga gaacagcatg agggtgactg cccccatgat taaattcaag atgaggtttg 77041 gatggggaca cagccaaacc atatcagaat acttctatca catcacttcc tctttatgtt 77101 gtggttaaca attttgagtt aaaaccagac tgctgctttg agaaacaaac cctgactata 77161 gagaaggcat tctgtccatg tcctaaggga aatgtttcgt tcagtttaaa tactctcatt 77221 ctcaaaatgt ggtaaaagtg cacccgagag tcactggagg gtagattatg agaaagaccc 77281 attaatgctg aacttgaagt accacaagtg ccgaaagagg ggaacgagca cctaYcctgg 77341 gtagatgatg gtcagatata tttccaaagc cagagaatct gggtcaattg agaaagaggg 77401 aaagtgacag atatgcaaat ttggattgat attatattaa tgaattcttg attatccaca 77461 tggtgaccta cagtaataat aaatgtacac acactgtaag ttacataggc acacttttaa 77521 ccatccccac acttaccagg gaatgttaga taggcagggt gaatgcaagg tgagtgagat 77581 ttctgatggt gcagaggaag aacgccaagg ttgctagatt tcttgttttc ttttctactg 77641 agactcctca gcagggtata ttttgaggta ggtatggcag caccgtgact tctgtggctt 77701 tccctatgaa gaagttgtaa tgtgtaatat tttcttctaa gaggtgacac aattatcagt 77761 cttctagcta tggttggtta agttctgata ccttcctgtt ggggagaaac tgtcagaagt
77821 tgtgttttca tctatgttct gaaagtgcct tatcctttct agtgttggaa agat tgacgc
77881 aaaaataaag aacccacagg aaattgacac cgagatttct caggactttc ttgctaacct
77941 tgcttcttca cctaatgcat taggagacca aaaaaagtta ccttgtcatt ttggtttttg
78001 tttttattta ttttacttta ctaatcttYt gaagaatctt gtacttcacg tccccacatt
78061 actgtggttg aaggggaacc tttctatctg aaacattgct cgtgttcact tgcacatgag
78121 attgaaacaa ccaccaaaag ctggtacaaa agcagtggat cacaggaaca tgtggagctg
78181 aaccσaagga gttcctcgag aattgctttg catgattgtg ttttggagtt ttggccagtt
78241 gagttgaatg acacaggatc ttactttttc caaatgaagt gagtaaccct ttct tttcaa
78301 aatgtatttc acagccctct tgtcctttgt tcagcaactc aaatatgcag taat ctgaaa
78361 ggtcagataa tcaScacatc cttttctttc ctactcttcc tatgacatga aatacattct
78421 Wtgttatgga acaRaataag tttatctctc tctgcttatt ttcttagtga cctt atgaa
78481 aggagattac tttgatagga tttcctttta ggggatcctt accaatgaca agtgacgatt
78541 gcatgaaagt cagttttaaa attcagctgc tcctgttgtc tacatgcccc cagt caaatg
78601 aaatcagcag ctcggacttc acgataatat taatgtgttg cgaatggggc agtgtcagct
78661 tcctgggtgg catccctggt ggggagcagg gatggggttg atgcagaaac accc tagtcc
78721 agtctgcagg ggctcactgg gagccaggtg gcagtgctag tggaggaagt gtgtgtctgg
78781 cagccaatcg caacccacag ctggcggcag tgagagaggg caacacggaa gggc tttgca
78841 ttttactcat gaggtggccc tagattgtgc cagaatactc gaaattgggt tgcataactt
78901 ccatgaaatg agcacagcca actgaaagca tcacccacac ttaccgaaca tgtt tctttt
78961 tagatgtacc tacctacata tgtaggtagt tttatagaga cttgagactg acctgtaaga
79021 aatagctcag ggccagctga aggtgatggt gtgtagattt catatgtagc agat ttcttt
79081 tagaagcact tctagagtga gtcctgatca ttatcaacca tgctgttgag agcagagtga
79141 gctaccactg tgaaaccttg gtagcacttc tgtRgttttg caccaaatca ggtcattttt
79201 gtttgttttt atacatagga actcccaggc atcagaaaaa aattaaataa ctct tttgat
79261 aaaaatcagt acatctttag atgacctttt aagagtgata attacagaaa tgggtcacaa
79321 ctgggatttt tcataacaag ctaaggaaga atgaatactc acaaatgggg taaaggaaaa
79381 agaacaacaa acaccgNccc ccccaccaca aacttccaac tcctgattga atgaaggcac
79441 aatttaaagg aataaagtat tctggacagg cctgagagag cacgttgaga ggaacagcca
79501 ggcatctatg atcatcactt ggagataaca gaagcaaatg gcattggcca tctt tctgat
79561 aYgggtagta gagaatacag cctggcttag gaagcaacaa tggaagcaag agat tgaggc
79621 aggatgtcag agagaggtgt ggagagacag ggtagcagat aggagatgct aagaaaaatg
79681 aggtgtccca gagtggataY tggagactga tcactatgag agtaaagtgW tgagrgagaga
79741 agcagctttg acaatggcct tgaaaataaa tgggattcta catggaagca ggttgtttta
79801 gacacccagg agcatagaag atacagacat attcaaatat agcataatta gtaagcagta
79861 tttactgcag atgtgtgtgt atacacatat gtgttctaac ttaRgtgtgt aacc-ctttgY
79921 agtttgatgt gggatctRtc agtgaacaga ctttacacct gaaaatttcc cRtt agaaca
79981 gtaattcttt aatttttagg agtacattgc taataatcaa atgccactga ggactgataa
80041 tttaatcctg cagtgaaaat cactttatcc caccaaattt taagaacgaa atca-actaag
80101 aaggaagggg atacaaaagg gataRttttc aatgatagag atgaagaaat gaagrgtagag
80161 ggaaatgtac acacagaaat ctaataaacc aatcctaggc tgacaggcag caag tcagc
80221 ttggtgagca gcctcagaag tgggggctgg tgtttatccc ctggtgtctg tgga-caaaaa
80281 tgagtggttt tcataaccag gatgggctgg gcctgcagca ggaaagtgtg gtca-cagctt
80341 tgggtcagtt ggcctcagtg ttaacccYag ccttggagct cctggatggc aggtgcagtg
80401 tgttgttgat tgtttcagtg ttcccagagc agtgtcctgc acatggagtg tcatcagtcc
80461 tctagcattt gttgagtgtt aggaattgag gattacagag gtagagaaca atgtagtctg
80521 aaaaaatggg gatattcatg taccctattc cttttaagca acaagtcata gagatccaga
80581 aatctctatc tctccaattc attgaggtca aagttgggga gacattacga aaacacactt
80641 gagaagaagg tgctgccaat gggatcctga atccatttca agagccaggt agctctatca
80701 tgtcccatgg ccatggaccc actgcctata actgtgacaa cagcctgcca cattctccag
80761 tcacggccaa tcttttataa attcatgccc aaggtgaagg ggccagattc attcjgattgt
80821 gaaagtgtag aattgtgcag agcacttctg gcctctgggg ccaaatagat gtgc tttgt
80881 atcctggccc catcttgtag caagtgtgtg gcctgagtga gttgtttaac ctgtctgaga
80941 tttagcattc tcatctgagc ctaaggaaaa tagtcatctc ccttgcatgt acatagtcta
81001 atacctggaa ctcagtaagt gttagtcttt tcttccttct atcctattgt agacctaaag
81061 gggaactgga agagcctaag gtgggcacaa atgtgtcagg catagaggat aacttaaaaa
81121 cacgcatctg ctgtatttag caaataaatc tatacatcac aggtgcagtg gaagrcaaaca
81181 tgaaatttga aacattttct ctttaaaatc ttcatttaaa aaatactgta ttgttttcca
81241 attccagatc accttttttt gttgttgttg ttgttgtttt tttgagatgg aatttcgctc
81301 ttgttaccca ggctggagtg caatggcgcg atctccactc actgcaacct cσgc:ctcctg
81361 cctcagcttc ccgagtagct gggattaccg tacccagcta atttttgtag ttttagtaga
81421 gacggagttt caccacattg gccaggctgg tctcaaactc ctgacctcag gtgatccacc
81481 tgccttggcc tcccaaagtg ctgggattac aggtgtgagc cactgcacct ggcc-tagtga
81541 tagtcctgat cactaatttc tgatcaggag taacaacaac tataaaatct attcacactc
81601 acttttggtc agtaaggcat ttaaagagct aattcaatta cactgagggc agcsactcca 81661 gactttggtt tattcaacag taaaagaagg ggattggaag aagttgcctt gagaaacaaa
81721 acctaatata tatatacaca catttagaaa acaacatcag gagtttatag accttttgaa
81781 accaaagcca ccctcccatc ctgggccaag actctctgaa cttatccatc agtgaagatc
81841 actgacattg taaagatttg cttttctgac atccataata tattgtctgc agtaggatat
81901 gtgcgtgtgt gcgtgtgcat gtgtgtgtct ctgtgtgtag actgcttagg ttcattta
81961 ttaccccctg ctcccatgac agtttttaaa gttcttgctc ttctgaatca agcggaggca
82021 gagcagggtt tgcacatcaa tgaatcaatc tctttaataa aaataaagga aaaatattgt
82081 aactggttac taaagggaag atgggtgata tttgcaaagt ttctgtagca t ataaaata
82141 cctttacact tttattccat agaaattata ctcagaaatg gaaattaaat g catcagaa
82201 gaaataaaca cagctgtttc actgaaagac aagtaactag taaaattgtg gaagttaaaa
82261 aattttttca gataacctgt gaaaacagtt actatcaaac actggtcaac agcacatcat
82321 tgtataaggt aatgctttta taatatttta actttaagac ttgatggaaa agataaaatt
82381 cccaaatgag gggctgagag ctaccattct ggtctcataa caaataagct gcctgatccc
82441 acatggctca cttgccctgt ttgagccaag tatcctcact ggcttgttgt caagagctga
82501 tacatagtat taaaatatgt tccacagtag tttccctgga tttggtgttc a taaatgat
82561 cacagtttct tctcccacac tcttccttca ttttccttct ctttcgataa gttagttttt
82621 aggaatgcta gtttaaggat ttccattttc tcctgtcaca tgtacttaac atgtaaaact
82681 caattgtata tgtttttctg aatatattag ttcattttat aaaattggaa tggtaatgc
82741 ttttataata ttttaacttt aaaactgaaa aatgaagaaa gcaaaaatca c cataaatc
82801 catcacagac tttttttttc tgtgaagcat ctgcttttta aaagtggtat attttatttt
82861 tttatgtttt ttcctctaag aattacgttg tgactatccc ttcacatctt t aaatgatct
82921 tctaaacatg ggctttcagt ttttatgtgc ctggtttcat ctaactaacc c ccttgtttc
82981 gtctaactaa tcccattgtt attggacatt tgtgaattgc ctatttttca c tattattta
83041 aaggctaaaa tgaataccat ttccacaaat ccttgggtgt ttatatgatt tgtccttcaa
83101 ccaaatccct aaatgtagaa ttactggatc agaggctgtg agcatgtttt t tgtctttt
83161 tcctcacact atcaaacttg tctccaggga gctctgccaa ttttacccca c acttgaaaa
83221 aagaatccca attttttgtc acctccacaa cacagggaaa taatggtccc agaatgttta
83281 aaatttgata tgaaaaattt ctaaaactcc tagtggtttt ttcacttttc t tagtaataa
83341 attaaacttt tgtatatatt tattgcatct tactgcaatc aggcaatttt g tgggttgcc
83401 tgtttatttt tttctgtttt cttcagttgg tatacctttt acctgttgaa t tttaaaagc
83461 tcttatacac catggaatac tatRcagcca taaaaaagca tgagttcatg t cttttgtag
83521 ggacatggat gaagctggaa accatcattc tcagaaaact aacacaggaa t agaaaacca
83581 aacactgcat gttctcactc ataagtggga ggtgaacaat gagaacacat ggacacaggg
83641 aggggaacat cacacaccgg ggcctgttgt gtggggtggg agggtagggg tgtatagca
83701 ttaggagaaa tacctaatgt agatgacaaa ttgatgggtt cagcaaacca c catggcacg
83761 tgtataccta tgtaacaaac ctgcacattc tccacatata ccccagaact t aaagtataa
83821 taaaaaaaaa agctctttta gaccacgcta taggaattat atatacacat acatagcgtg
83881 tgtgagtgta gtgtgtgtat gcataaaaaa catacgcact cccatccaca c acatacgca
83941 acacaaattg tgtagttcag gggtccccaa tccccatgcc actccccctc actaacatta
84001 ccacctcctg tgagatccgc agctgcatta gactctcaca ggagtaagaa ccctattgtg
84061 aactgtgcat gcgaggaatc tatgttgcat gctccttatg agaatctaat gcctgatgat
84121 ctgtcactgt ctcccatcac ccccagatag gaccacctat ttgcaggaaa a-caagctcag
84181 ggctccactg attctacatt atggtgagtt gtataattat ctcattatat a-ttacagtgt
84241 aataacaata gaaataaagt gcacaataaa tgtaatgcgc ctgaatcatc cccaaaccaa
84301 ccattccccg ctcaacccct gcccaccctg gtccatggaa aagttgtcat t catgaaatc
84361 agtctctgtg tcaaaacggt tggggacagc tgatgtagtt tatatggaat a-acaaatctg
84421 aataatatga ctctgtcgtg gaaactttaa agacctataa gagagtggtc tgaacagaac
84481 ttgggaaatc tgaagcgagt gatgataata tccttgaaat ttttgtttgt grccttatgct
84541 tgaacactgt ttacttgtga tttccaaaga cagctcttat ctgaaatgtt ttctaaacac
84601 tcgaatcagt cctgagttga ctttattcta tttcccatca atgtacaaat grtgttacagt
84661 atatgtaaat tagtgaggct tggtgtgctg agttttaaga aattccgttc 3"ggtgcagtg
84721 gctcacacct gtaatcccag cactttgtga ggctgaggtg ggcggattat taggtcaggt
84781 gatcgagacc atgctggcta atatgatgaa accccgtctc tactaaaaat a-caaaaaatt
84841 agctgggtgt ggtggcacat gcctgtagtc ccaactgctc gggaggctga grgaaggagaa
84901 tcacttgaac ccgggaggca gaggttgcag cgagccgaga ctgggccact grcactccagc
84961 ctaggggaga gagcgatact ccgtctcaaa aaaaaaaaaa tgaaattcca a-agtgcagct
85021 atttaaatta tgagcattgg tgcaccaagg atatttagct aaacaattga crcacagggct
85081 aagtattcta agcctgttga ctgatcatga cttcacccga gagcaaggag grctaattcag
85141 tagataattg attggaaagg aaaatgaaga gtctctgatc ttttctatag crttgaaaaaa
85201 ttagtttggc tttataaaat tttgacttat acataaataa tttactgacg tgaggtacac
85261 atgtgggtgc ttcacgggca cattctatgc acaatgggtc tagccccagt grgctgccagc
85321 tctgagggag aagtctgtgg gcagtaggtt ctccttgctt ggtgtttgca graaacagtgt
85381 ccaatggtca aggatggcca ttcagccccc agacatccca tgtggtccct grcatggctct
85441 gggacctacc tctgggtgtc agatgtgctg gattgaagaa agtggcttta ttacaattag
85501 tattaattcc tgtgacatgt atggaaatgt gtgtgWgaga gagagagatg tttgagtgta 85561 cctatggatt tgaatattgc tgatgcattt ctaatcagct cgctggcttc tgatggaggg
85621 tgtcaaaggt gtgggtggtc tgctagctac tcattctctg agtaattctc cacccatccc
85681 actatccacc ccttggatgc atagtccaga atacacaaaa ttggactgaa catgtatgaa
85741 atagagttgt gactcaagca agggtttttg aagtagtgtt ctctctctct ctctgtctct
85801 cgctgtttct ctctctctgc atgtgtgtRa aagagagaga tgaaagaata ttgatgaaag
85861 cagctacagt gctcatattg ccccatgctc tacttcccag catatattaa taatgataat
85921 catgccaaca gcaatgggat cgcatttaat tgtttcagta aaagtagtac caagtaactg
85981 ggacatatgt ccaggaattg ctactttcca ttcttttttc ctttttctct aaagatcttt
86041 aactcaaaaa tttggatcac tgtaatatca atttggcttt tacttaaagt attttaactt
86101 gttttattaa aaacagaact gtaaaaagct actactggag aacaataaaa acccaacgat
86161 aaagaagaac gccgagtttg aagatcaggg gtattactcc tgcgtgcatt tccttcatca
86221 taatggaaaa ctatttaata tcaccaaaac cttcaatata acaatagtgg aaggtaaggg
86281 aaatcttaga attgggaaga aacagacgta ttttagtaaa atggaatttt ttcattcttc
86341 aaaactgtgt aggaattgag agtccactta gttggggttg tgaccacacc actagttcaa
86401 atatgatggt caaaatcttc attcYggtgc tcctctactt ggctaaataa acctttcttt
86461 ttggcaggaa atgaaaatct gtatgaataa acctcacatg agtcagctct ctcttatata
86521 tgaaatttga gtaaattgtg gaatcttttg ttgttgaatt tacattttca ctttacaagt
86581 atttagtgaa gatatctata ctcaataaac tgtacttagc acaaggaggc agggaagcaa
86641 ggaagtatga gatgaagtga gcactgtact attctcaagg gatttgattc taatcaggag
86701 aggcaataag ctacataaag gtgtatgaaa cagcatcatc tgtgaggctg caagagtgca
86761 gggggaggtt ggaggaagga cagatgcagg aggctccatt tgacctgggt cttggagggg
86821 gagcctcatg aaacagtgac ctgctggggg aagggatctc cactgggaga gtgtaaggaa
86881 cactgatgtg ctggtgggag gggagggatg atggacccag gctgtgtgtg atggaggaac
86941 agaatcctgg gacattaaag gtatttaatt aaacctcacc cagtgaagat attcatcata
87001 aggcacagcc aatgattgat catccagtcc cttcttggga actatcaagg aaatgaccaa
87061 atcacacagc agtgtagtcc agattttaat atctgattgt tgaagtcttt tttttccatt
87121 gagtccaaat atcccttctc gtagcttcca accactgatt ttgatttgcc ttcaagaatt
87181 tcacagatta aatctggctc cttcttaaaa tgacagctcc tttcgtgatt tgaagacagg
87241 ttgcttatcc agtctggatt tttttcccca tcatcctgag aaactggaaa ctgtaacact
87301 tgtgtgggtg gcttgttcaa caaaatctgt gggctcacat ttgctacagc ctttgcttta
87361 gcaacatctt tcttcttcac tacaaccata tagctatata cacccacatg ttgccacagt
87421 aacaaattat cccaagttta gtgtcttcgg taaaatcaag gttttgccag aattgcttta
87481 cttctggagg ctgtagggga aaatgcgttt cttttatttt tttatttatt ttatattttt
87541 gagatggagt cttgctctgt tgcctaggct gcagtgcagt ggcgcagcct tggggctcac
87601 tgcaagctcc gcctcctggg ttcacaccat tctcctgcct cagcctcccg agtagctggg
87661 actacaggca cccgccacca ctcccggcta atttttatat tttttttagt agagacgggg
87721 tttcaccgtg ttagccagga tggtctcgat ctcctgacct cgtgatcccc ctgccttggt
87781 ctcccaaagt actgggatta caggcataag ccactgcacc aggctggaaa atgtgtttct
87841 ttgcctttgc tttctccagc ttctagagac cacttgcatt tcttggcttg tgccacttca
87901 tttcagagcc aaacacattt gcttccctca cctcatctcc tttttgactc tgacctttct
87961 gtctccctct gatgaggacc ttgagacagc attgtgccca cctagataat ccagggtgat
88021 ccccctatct caagatcctt aatttaatca cacctagagg ttccttttgc catgtaacat
88081 atYgtattca caggaactca ggagtaggat gtgggaaact tcagggtcta ttattctgcc
88141 tgccacagcc cagaacctgg gaaacccata actgaatttt aaactcaaaa acttaaattc
88201 tgtgtataat catctaccct aaactctcca actttacttt cctacatcta tttttaatct
88261 catataaatc tctgttactt tgatactttc agaacctaca ccctctttcc caccatcttt
88321 gctttctgcc catcagcagc tctttccttc cttctttgat gaagctgtag gaatatccat
88381 tattaaaagg gtgcttgtta tgggccaggg atagtgccaa gtactggagt tgaatcatgt
88441 catataatcc tcacaacagc tctgtgagac tgtggccttg ggtgagttaa tttccttagt
88501 tcctctctgc ctcagattcc tcatcatgaa atgggacagt aatggttcat ccctcgtagg
88561 gttggctgac aatgactgag tgagtgtgtg tacagctcta ggatggctct agggacagta
88621 agagttctgc tgtaatgacc atctcccact gctaggttcc caaacctcac ctgcagcaca
88681 agctattctt ctcccataat tgtccatctt atttttcttg tcttcttgga gaatgtcaac
88741 tgagtctctc aggactccac tcaaatgtcR ctcctccttc atgcccccat ggcctcttgt
88801 ttgtatttct gattgctgtc agaattgcaa tacatgtgtg tctctgtcaa taacttgaaa
88861 ggtttctgga aaggtttgca ctgacttctg ttcctcatct ttgcatcttg gatacctaca
88921 attggcactt ggcacataaa ggtgctcatt acatgcctgt tgtgtgcatc actgagacag
88981 aaacaactcc tttgatgcca catacaacaa gaagtctaga cacttcacca tcctggctat
89041 ttttctttgg atttggcaaa gtttgccacg agtctacaga aattagagct tggagttggg
89101 gaagacagcc aggaggtgtt ctgacctgtg ttgaggacag agaggttctg agctcgtgcc
89161 ttctccatgt tgtgtcttta ttacagtccc cttgccttca cagatggaga tctctcagct
89221 gctacatagt gactgctgta gtggtggaaa ggtgtgatac ctctcctccc catcctaagg
89281 gtcatggcaa tgttcccata acaaaagaca gattaacaag gggcaagcaa gttttatgtg
89341 acatgggagc cttcagaaat gaagaccctg gggccgggtg tggtggctca tgctggtaat
89401 cctagcactt tgggaggccg aggcggatgg atcacctgag gccaggagtt cgggacaggc 89461 ctggccaaca tggcaaaacc ccatctctac taaaaacaga aaaattagct gggcttggtg
89521 gtgggcacct gtaatcccag ctacttggga gactgaggca gggagaattg cttgaaccca
89581 ggagatggag gttgcagtga gccgaggttg tgccattgca ctccagccca ggtgacagag
89641 caagactcgg tctcaaaaaa aaaaaaaaaa aaaaaaggaa agaaatgaat accctaagac
89701 tcagggaaac ccgttttttt ctttttaaat gcttaggttc tagaagcatg gacagccatg
89761 tagaaatgtg actggacaaa agggtatgac ctaatgctaa tggactgagt ggggaaaccc
89821 agcaagacct gtccagattc ttcttggcct ctctgttata tttccttttc ctgggtagag
89881 ggcagagggt cttaagactt actgtcagac caaagaaggc caaagaattt atagccaact
89941 cctagacaga aaggcaggag aaggttagag tcatgcttct aggttctatg gcttactttg
90001 gggaaaagga ttctagtttt tatgatctgc ctttgggaag agggagtctg gtttctgtga
90061 cttgctttgg ggagaatgga ggcatgaagc aggagggtca gagagatctt gctttttgag
90121 gctgctttga ggccttccaa tgtcgttgag tttaaagtac tcagcctgcc aaaacaccat
90181 actttgggac tgtttttgga gcccaggagt tccattgcct tcagcttgtg ctcgtgaatc
90241 acagtcacct gaattcctac tgggcatctg ccactttcct ggtcttatgc tctggctgat
90301 cgggtggcgt ctcctcctac tgctgacaac ctctatgcca ttttgactct gatagcctcc
90361 taggtaggct ggccatgtca agggcatgca ctaagatgtt gtcttccttc catgacctac
90421 atgggactgc acccttcact ttacaccagt tgtgcaaact cagggctgat ctggatttcc
90481 aatgatataa tttgagtgtt agtagacagc atcctttgct gaagatgtac ttcacactgc
90541 cccttctcaa gtctcccatg taagtttctg ggggaaaaaa tggatccaga gaaaggtagt
90601 cagtagcagt tttccccctc aYaccgaaat tgcctcctgc cctttgtctt tgaattcaag
90661 ccggtgttgc ttcttactgt cagacctgag agttagttct ttccctggat acatctcagc
90721 tcctcctgcc tgtttgccaa cattccaggc ttgcccagag actccaaatc ccaggataac
90781 ccagacctga ctctgaactc cggagtccac tgtgctggtt tcattctcct gttcttgctc
90841 acatatctgc ccactgcatt ctcaactgct cactctggca ctgcactttc tgagagggct
90901 cagggaggtg tgggagctgc aggWgcactc ctgagtctca ctgtactcca ctcaaccagg
90961 cattctgctt gctgagcacc tgcaagtccc agaagggatg ttctggacat tgcttgggaa
91021 tgcctccaaa gcagtggggc tactagcagg gaacagtcct ggtcatgagg aaagttacca
91081 atgaggatat cagggctaac aataacttga ctatgcacca gttcaaatct atgaccgcag
91141 ctgctcttag ggtttgcagt tgccagctgc cttaagcaag agcctgttgg gtgatgactt
91201 acttcccaag catcaccaga tggggactga gggggcagaa tttatgtgca gtacttccag
91261 tcggggtcag aagccactca ggagcagaag tagaacttgg cctacaggca tgaacttaac
91321 agcagggcca gggccaaggt gaggttcctg gggcacaata ttgaagggac actgctctca
91381 gcatcctgca agggaacggt gggcacatag agtgagggat ttgcttttct caacctgtct
91441 tggccctgca acctgtaaat ccatcactgg ccagctgagg aggacagatg gagagaatcg
91501 agacagggca gaaaggctct tcccagtgat tttgcatggt ttgactcttg cacgtttgat
91561 catctgagag tcaggctgca gtggatgggc atcttcctct gccttttagt tgaattgagc
91621 agaagctgca gatMtgagtg agagaaaacc agatacaagg tgctttcaac atctgtgacc
91681 tttagttaat gcaaatagga ctcaagtgaa cgtaaaccag taactattgg aatctttgtt
91741 acatgaaatg agcatattat catagatgct tgtcataaag aagctcaagg caacactaat
91801 acatttgtct tttcttttgt cacttctaga tcgcagtaat atagttccgg ttcttcttgg
91861 accaaagctt aaccatgttg cagtggaatt aggtatattt caatatacat atattctgca
91921 tttataagta ggggacataa tagagccttc caagcgtaaa tatgattcat tattgaatga
91981 cactggatac acatttcata tttactgaat aacattacaa aactaagaRa agagtgccat
92041 tttttgaatg ttgccacttt taacctgact taaaagtggc aacattttaa agttcaagag
92101 acagtggaac tgcctgtggt ctgtagacta aggtttttgt tgtgctgtgt gtggcttgtc
92161 tttaactctc tctatggtca tttctaaata tgaaaattta ggccgggcat ggtggctcac
92221 gcctgtaatc ccagcacttt gggaggccga ggcaggtgaa tcacttgagg tcaggagttt
92281 gagaccaacc tgaccagcac ggtgaaaccc catctctact aaaaatacaa aaattagcca
92341 ggcatggtgg catgcacctg tagtcccagc tactcaggag actgaggcag gagaatctct
92401 tgaacccagg aggcaaggtt gtaatgagct gaaatcacac cactgcactc cagcctgggc
92461 aacggagcaa gactctatct caaaaataat aataataata acaataataa atttaaaaat
92521 tccgtgagag cactctggag agatgagtca aactaatttt gtggtgtgaa tgtttgatta
92581 attgattcac tttgaatcaa ttgactgaat tgattgtata tttggagttt gtctagataa
92641 gtcttatgaa tcaacatgtc caattgagta atttctttca aaagagaaag gaaagaaaga
92701 aaggaagaaa ttcacatatg ctaaatatgc taagccaggt atcatgctag gtcattgaaa
92761 tatattgttg aattaaatcc tccaagcaac actgaggcat gtattctcat tttatgaatt
92821 aaataattga agtgcaaaaa ggctaagtaa cttgtctaaa gttaaatcac taaaaagtgg
92881 caagtctctg tttggggact ttgcttccaa agtccccacc ttataaccac agttggggtc
92941 acagtggttt atatgaccac atgggcccag tgcagctggg tcctatgcca tttgtacatg
93001 aggtttacct gctttatatt tttatttatt tctgtctttg tctttcttat ttttttcttc
93061 tactcagtgg ggcttaactt gtatcttttg ttctagtttg ttgacctgaa gagttagata
93121 attaatttta attatcctct ggtagtatat accttcaaac tccaagtttc cctgtaaaca
93181 ctactttagc tgtttctcat attttcattc tattcagttt aaaccattac ttaaaatttc
93241 ccttatgatt tctttttcca acaaaaaaaa ttggtatttc ttaatttcca aatatttggt
93301 gaactttcta gttcttgtct cttattcatg tccagtttag attcattata gtccaagatt 93361 atacacagtg tcatttcaac cttttggaat ttgtagtgac ttacttaagg cccacagtat
93421 ggtatatctt gctgaatgtt ccaagtgcat ttgaaacaaa ggtatattct ataggttttt
93481 gttttattat tctttaaatg tctatttggt taagttcatt aatggtgttg ttcaaaaaat
93541 ttatatcctg actaatcttt tatctgcttg ttccatgtgt tgctgaaaga gatgtgaata
93601 tctccagcta ttatggtcaa tgtgtctcta tctcctttag ttctgtcaat ttttgtctta
93661 catagtttgg agctatctta tatgcataca cggatttatg ctcgttgaat taacactttt
93721 atcattatga aatatctctc tttatctatc ataacacttc ctctctcaat gtgtagctct
93781 gtcatatgaa ataatcacac aagttttctt ttgcttggaa ttggcatatt tgtctttttt
93841 taaacatccc tttactacta acattttttt ttgttctata cataagtgtc tctcataaac
93901 tgcatgtatt tgggtctttt ttgaaatatg gtcagtatgg tgtttagtcc atctgtatat
93961 ttaaaattac tgttacagtt gctatatcat atatgcatga tatacaaata ttcaatttat
94021 tctttttaaa ataaattaca ctttgttgaa aatgaccata tttccatcca cttgtttatc
94081 ttttcctcta ttttctttca aacagttaca gtttttaatc tgctaaattc agcatctgta
94141 ggtctgcttc tattagctgt cttttctatt gattatggtg cacattttct gtgtctttgt
94201 atgtctctta actttttatt gttgttgatc tttatgtatc aaacaattaa agtgaataca
94261 gtttgtgtta ttttttctta caagtaggta gcctgagagt tgagtatctc agttgactca
94321 gaattgagtt ggggtggctg ggatgtaggt atgttcactc caatctgtct tcatctctga
94381 tagctggtga gggagggggt gctgcagtca tgtgtttgat gcaggcctct tctctaatga
94441 gacttgctct cctgattacc atgagactgc aagtgatatc atacagcctt tacatccttt
94501 tacgctgtcc gagcgcttag cagtaattct gcaagcctgt gcagctgccg agagcttcac
94561 tggattttct tgtttctatg agactctttc tgttaattac aaaccaaagc aaattcttcc
94621 atggaatgaa atggccacct atcttagctc accctagaaa ggatccttct taagtacgct
94681 tgtagttcaa aaatttctct ttattttctc tgtactttga tgtctttaat gtttgcttaa
94741 tttaattttt ttgtgattta tccatttggt ttatctagaa gtctcagtga gagtattgtc
94801 ctgatgctac gaaaagaaag tacactgatc actctaagtt ttaatagttg attaaaaaat
94861 aaatgtttaa aaagaagcca aatcatgttt tgatgatgac ttgtaattgc tacctatttc
94921 ttctgcttta tatattttgt tttatttaaa gcaaggcata tttattctct ttctgggatg
94981 gagcaccacg ttttgcttta ggttaacata cattgattat attgttttga aacttttaag
95041 aaacctgagt ttcaaaaatc agaactttag ttgccaactt ttaccaggaa aaaacgtaag
95101 gctcaactgc tctgctttgc tgaatgaaga ggatgtaatt tattggatgt tYggggaaga
95161 aaatggatcg gatcctaata tacatgaaga gaaagaaatg agaattatgt atgtatgtgt
95221 aatatatatg tcatgatata taccatataa caatcatata tattatatat aacatcatat
95281 taaaaacact gggtggctga tgtgtatttt gggctagttt aaattataat tataatggac
95341 atattttRta attatagtgg ccatacccta ggtggacgca ttatgcagaa atgtattgcc
95401 aagatctaag ctggaaaaga aggtccatga gaaggccatt gagggtattt agcatcacct
95461 tataaagtag cacttggtca gtcaggatcc gatggggatg gggattttac ttagcttctt
95521 agaaaagggc agttgcctag gccaagcttt tttttatttt gaaaaatttg ttaagttgtt
95581 tatttttcta atgggccaaa aaggctccaa atggcatgca tattgatagt taaataagcc
95641 tatattcttc cattaaggaa tggtcaaact tataaaaaga atcagtctaa acatatagtc
95701 acctaagctt ttctgaatga ctttgggtca tactgtaagt attcattatt atactgatac
95761 actactcagg gtctagtgag tgctgagcct aagttgtcta ccacctttgc tgcacttgtt
95821 gagttttttc ttctgctttt tacacatttt ttggtacctt ctttgttacc atgcttgcag
95881 ctctacattc ttgctgacac ttgtctacaa gctctttaca ccacaaagtc tggcttcttg
95941 cccgggagca ggcatgtggt tcatgcccac tacatgttga attcatttga aatttgtgga
96001 tctcctgcca tcatatctca tcctcagcca ctggcctcca tttgagtttt gtatttctcc
96061 ctttggataa tctctttcta atttttagag gggtagaaaa ccacagtgaa tttcttagaa
96121 atgcagctta agctacaaaa gcagRgaggt ctttctttat agttgggtgc acacaccttt
96181 gatatcatct gttttgtcct ctcaatggcc tcctgtgttt tacttctgga tttcattggt
96241 tttagatggt tgttatttct ggatgggtga cttaggaaaa gaattacatt ccaaaatgta
96301 cttgaggcag ttggaggcta cagtggggct ctgtgtcccg ggtcctagat atccctgttg
96361 ctaggaatgt gggcacatgg ggcccatgtc tggctgtgtt gactggtgta gctatcagag
96421 cctgtcattg gtgggggaag tggatgtcat aagtgtttac ctggcatcaa ccacaggaca
96481 acttgaatcc tttaaggaag agaaaaagaa cgtgctgcca gtggctttct caagtcattt
96541 tctgacactc atggaacaac ttaactggca cttctcatgt gcctcggggt gcttgagaac
96601 agtgttatgt tttttaatgc tgaacacatt aaaccagttt gttggattcc atggacaaat
96661 gtaatacgaa tctgcatcta tgctaaacaa cttacagcct tgtcataatt agtgggaacc
96721 actctgtgga aagaacccca agttgttagg aagagagaag tagagaaaaa taattgagag
96781 agaatatttt ctYatatttt caacttagca tcatgatctt ccagccattt aaacttcagg
96841 taattgacag caccattccc aaatggcctc aggagggctg tttctgtcag ttctgatgct
96901 ccacggagga ggggacgttt attgtagtcc atgctttaag agtactggcc agaaagggaa
96961 gaaataatgc aggcaacatc acagctgcct tcaagcattt taaacatgtg aattMccctc
97021 tcaagggtaa cgaacagagc ctactgctaa attattttgc cctYttacag gactccagaa
97081 ggcaaatggc atgcttcaaa agtattgaga attgaaaata ttggtgaaag caatctaaat
97141 gttttatata attgcactgt ggccagcacg ggaggcacag acaccaaaag cttcatcttg
97201 gtgagaaaag gtgagaaaga tttatttttg gaagttttga aacttagctc attgctactg 97261 agagacattt caaagatggc cactttctca ttttccacac cagaacccag ctcctgagag
97321 gggaaatcag tcacctcatg tcacaggcat tcagtggggc ccctctgtct catgatgcca
97381 agcagagaat gaaaacagaa ctcattcacc tgctctcaca gtcatattcc atcccatgtg
97441 gaaatcgggg ggcctgaggc ttggagatac agatgctgag agtgaggctc atggggaggc
97501 catcaggaca acccctgcac ccagcactgc acccagagca gccagagggg agtttgcaga
97561 tctgcgtggg gtgaggccag tgcaaacttg gtgtgactgc tgctccagcc tgcctcagca
97621 gggtaccagg ctcagggtcc ttgtgtgtgc tcattcattc attgcctcct gaacttggca
97681 agcaggccat tgatagccct gatctgtggg Mtcttaaagt ttttcagtgc tcacctgatg
97741 gagggcccca gggtcgccat ccctttcctc caccaaagta gcacagccca gggccttcag
97801 cccagtagct gctcagaaat ggctgtgact ggagccagaa agctgtgatt tccaKttgtc
97861 actactcatt cactgttcat tcccaggctc caccatcaac tccctggata tgtagagaaa
97921 ggtcaagatc tgcaagagag agagaaaggg agagagacag agactaacac acccagagac
97981 agatggagac ggagagagac agacacagag agaggagaaa gagagataca tgagatggag
98041 ggacagagac aaacagacaa ctctagagag atgaagacag aaagagaaag agaaagagag
98101 acagagacac agagagacag agaaatgaga gagacaggga gagacacaga gacagaggaa
98161 cagagaaaga gggagataga gaggcagaga catgaaggga tgcaaataca gagagatgag
98221 agtgaaacag acagagagac agagtaaggg agagatacac acagacacac acaaacatgc
98281 agagacagcc acacacacag actgggcctt ggctttgtga gaaacggaag gagtgggaca
98341 ggaagagcac aaaggctgga aaccccctcc agctgggcta tcctggtgcc caggggcagc
98401 tcccccagca cacatgtttt agagccgcct ctctaccata tgcactcata acaacagctc
98461 acatcccata catgttaatt acatgacagg atctgggtga agttcctgcc atgatctcat
98521 ccagtcttaa cgacaagctt tatagaggtg aagaaacttg cccagggtca cacggcaggt
98581 gaaggtattg aaactcagac ccgattaaat ctggaatctg tgttcttacc ttctgcaggg
98641 cttgtcgcct gtggtcttcc acccctgtgt gattgcctgt gctgtggtcc actcacttgt
98701 gagggagYgg ggctcaaatc tttgttggac catcacctgg ccaggctttc ctggggcctg
98761 ctcaccaccg gatcacctct cctttcttag aacagggcag gactgtccta ttcctgccct
98821 agacgcttct ggccagtcaa ttctcctgct gctgctctca caaatgtagg tttagaaatt
98881 ggggctcaca acccaccatc accccgtgcc aatgtgtgcg tgcgtgtttt tgcaaatgtg
98941 tgacacagtt
WASPIP genomic sequence (SEQ IDNO: 5)
>2: 175603701-175699600
1 ccccccaggg ctctggacac agatataaac cttggtgcag ccagcagtgg gggatggaaa
61 tgaggagaaa aaccagactg ggtagggccg ccatctgctc tgacacacca ctgggagggc
121 tctcaggacg ccctgggccc caggggaaag tgttcttgga aacttacagg tgtgcagtga
181 atgtcagttc cttttctctc agttccccRt gagtcaggtt tgaagatggg acaactgctg
241 aggtttggct gagggtggca cattcctcgc ccttttgcag ctgtggtgga gcggaaaact
301 ctgaattgct ccacacactt gggtgcaaga gatgtgcacc cctttttcct gcctctggga
361 tcccctcttc tttgaggagc agcgtatctg tctctcctgt gaaacagtgg cttccattgc
421 tttcctttct ggataattcc atttctttcc tgaagagcca agaactttct tttttttttt
481 tttttgagat ggagtctcac tctatcaccg aggctggagt gcagtggcgt gatcttggct
541 cactgcaacc tccgcctccc gggttcaagc gattctcctg cttcaggctc ctgagtagct
601 gggactatag gcgaacgcca ccacgcctgg ctaatttttg tatttttagt agagacaggg
661 tttcaccata ttggtcaggc tggtcttgaa ctcctgacct catgatccac ccacctcagc
721 ctcccaaagt gttgggatta caggcgtgag ccattgcgcc cggccaagcc aagaactttc
781 aaaagtcctg gttgaacttt ttccaggaca gcttataaaa cacacagaag ttctgagagc
841 tcattcactt gagcatacga gagtctgaaa cctcagagca aaaggctagt tttctttcca
901 gagaggaagc gcagggagaa agcaccctct tcttctatca aatatgtctc caatagaaat
961 aagaacaggg cacaaattac cacatcaata atttaccctg ccccactgga tccccaatcc
1021 ctctgggact aacttagaga gccttgaaaa atttccctct cagcccgttt cttcagctac
1081 aaacggtgct gatactgagc ttacaaagac attgtgacta ggaaatgaaa tagctatttg
1141 tgaagctcaa tacttagggt tctaataagt atattttctt ttcttttttt cttcataaga
1201 ggaattgcct gctttcatgg aattataata tctgaattgg gtggctcaga ttacaggggt 1261 ctgagaacag aacattgtgc tgggggggtg gggtggggga aggggagagc aagtggggaa
1321 ggagcagggt ggggttccca gaggcttgtc tccccttctc tttgcgggga ggtgaggagc 1381 aggactgggg ggatatggaa ggagcaggct ggggctccca aaggcttgtc tccccttctc 1441 tttatggttc tgagcaggtg tcttaggtat tgggaggccc ctttgtatct tcaacggtgg 1501 ctccaaacct gactgatcac taaaattacg tggagaatct taaaacattc ctaccccagc 1561 cccttacagc cctttctctc tggctaagaa tctgattcag tagggctggg taagatgagt 1621 gaaaatgctt attttttaaa agtccccacg tgattctgat gaccagtaag gtttgattta 1681 ttattctaaa atacataaaa tatacgctat tctaaaatat attcctgcct gaaagtctga 1741 tagtgaaaaa tatgtccata ttatctcagt gaggtgcata aagagtagtg cagggaagcc 1801 atgagctgcc ttgacttccc agaagggaag atacttctgt gccactatca aaaccacacg
1861 gacattgtgg catacttcat aaagcctgag tcctgatttc ttttctgtga gaaaattttc
1921 atcaaggtag ggaagatcaa agcctaccaa gtgccttgct caagtaatct gagctgctct
1981 cattcccaaa cactttcatg agggagacct tacttttttc ttttcttttc tttttttttt
2041 tttttttgag atggagtctc actccattgc ccaggctgga gtgcaattct gcgatctcgg
2101 ctctctgcaa cctctgcctc ctgggttcca gtgattctcc tgcctcaccc tcccgagtag
2161 ctgggactat aggcacacgc caccatgcct ggctaatttt tgtatttttt agtacagaca
2221 gggttttgca atgttggcaa ggctggtctg gaactcctga cctcaggtga tttgcccgcc
2281 ttggcctccc aaagtgctgg gattacaggc atgagccacc gttcctagcc cgaggtagac
2341 ctttaattag taatttcttt ttatgtgaaa gtaaatcata atgaccagaa acacttgaaa
2401 cctttttttc ttctctatat tctctctttt gttccagtta ttgaaagcat gggaacccct
2461 acctctctaa gatgcaacct ctgagcattc tgggtttttt tgtttgtttg cttgattttt
2521 ttgagacgga gtcactctgt tgccgaggct ggagtgcagt ggcacaatct cagctcactg
2581 caacctccac ctcccagatt caagcaattc ttccgcctta gccccctaag tagctgggac
2641 tgcaggaagg agccaccatg cctggctaat tttttgtatt tttagtagag acaggttttc
2701 accatattgg ctaggctggt cttgaactct tgagttcaag tgattcgcct gccttggcct
2761 cccaaagtgc tgggattaca agtgtgcgcc accacgcccg gcctctctga gcattctgat
2821 gagagaaaat atgaggataa taggcctgag gactgtgaac tggctgctga gagggtctat 2881 tagaagccgg ttaatcagat ttatttccta actactagat tagatcagca cgctgagaaa 2941 atgagaatta gagttttggc ggaagagagt ttggggaatc aaaagaattt gggagcattt 3001 aacatttaga gaaaggctca gggaggccag aggacaggag agcaccgtga gcctaggtgg
3061 ggaggaagag ggaggggcca gagactaaga agatcacaga ggtagaaagc ttccaaaaat 3121 aataattatt tccctcagtc ccttatggtt cttgccagcc tattcccatc ccacatttcc 3181 ctcagctctt gtctctctct catcctggta gaagtgagaa tcaagctagt ttcttgagct 3241 agtttcaaaa tgaccaaagt ggaagtctag gaaacccttg gatgtagtca gtaaaatgcc 3301 caaatgtctc tacagctttg tgcctttgta gagatgcctt agtggggccg tgctcaggga 3361 tctttcacaa gcattctgga gcttggagga catcttcatt actcacattt taaaaaacgt 3421 ttaaataatg tctgtctatg ctgtttgcgg tgtgtgtatg cattttgcat tttttaatag 3481 ggctgggata ctgaagtcat gttgaaacaa aactggctca ctactgttaa gaggtttggt 3541 ttttgagttt gctgtcattt atagcaggca aacaaaatct aaaaattaag tttcctgatt 3601 ctaagtgcac tgacttacac cttttcaaaa ggaacaaagg atgtactgaa agtgaataaa 3661 tgattgcagg gcttcagaca ccaactttaa cagcaccaag tagtaaaata ttactagatt 3721 tttttatttt tgtctaaaaa gttatgctta ggccaggcgc agtggctcac acttgtaatc 3781 ccaggacttt gggaggcaga ggcaggcgga tcacctgagg tcaggagttg gagatcagcc 3841 tgggcaacac ggtgaaaccc cacctctact aaaaatacaa aattagccgg gcgcagtggc 3901 acatgcctgt aatcccagct acttgggagg ctgaggcagg agaatcactt gaacctggga 3961 ggcggaggat gctgtgagct gagatcgtac cattgcactc cagcctgggc aacaagagta 4021 aatctccgtc tcaccaaaaa aaaaaaaaaa aaaaaaaaaa agttatgctt aggacctcat 4081 tggatagaat taacattcta taacctataa cacttatttc aatggggtta agtttacttg 4141 ggggtactta gcataggata gtcaggaaga cttttctgca ttttcttata ataatgatgg 4201 tgatatcaga agttctcact tccagcctgc tgctgtaagt actcccttga gacatccttg 4261 actgggtgac ctggaggaag cagatggact gttcccagga gcctgaggtg cacatcactg 4321 tcagtttctg ccctgggcca tgaaatccca aactgaagtc cattggccca aactggtgac 4381 tgagtcacac aggattgttt acctgacttt ccctcttttc ttatttttat tcttttctca 4441 tctcttgtgt aaaaaaatga aatatacttt gggaggccaa ggcaggagga ttgtttgagt 4501 ccaggagttc gagaccagcc ttggtaacac agtgagaccc tgtctctaca aaaactttag 4561 aaattagcca agtattgtgg catgttcctg tagtcccagc tactcagaag gctgaggcag 4621 gaggatcaca caagcccagg aattcgcggc tgcagtgatc catgattgcg tcactgcact 4681 ctgacctggg tgacagagtg agaccctttc tctaaaacaa aacaaaaaca aaaaaaccaa 4741 atgtataaaa attgttattt caaaataaaa acagaattgt ataaggaacg cccaggtaca 4801 catcacccag cttcccaact attattcaca gccaggcatt tcctaccctc acttccttac 4861 ttctactgga ctttttggag acatttgagg taaatctcag atgtcatatt tctgctataa 4921 atatgtcagc atgtgcctct aaaaaatact aactctttta gaagacataa ccacaatacc 4981 tttatccttt ctaaaaatat tgacaataag tccttaatat catcaaatat ccagtcaggt 5041 ttaaatttcc tcaatcattt tataggtgtc attttacaat tactgtgttt gaatcaggat 5101 ccaaacaggg tccaaacatt aatcatttta atctataaat gctccttctc ttaagtacat 5161 tttaatctaa gatgctccct ctcctttttt tttgagacag agtcttgctc tgtcgcccag 5221 gctggaatgc agtggcacag tctcagctca ctgcaacctc cgcctcccgg gttcaagcga 5281 ttaacctgcc tcactctcct gagtagctgt gattacaggc gcgtgccacc atgcctggct 5341 gatgtttgta tttttagtag agacagggtt tcaccatgtt ggtcaggctg gtctcgaact 5401 cctgacctcg tgatctgccc acctcagcct cccaaagtgc tgggattata ggcatgagcc 5461 accgcaccca gcctcctttt ctgttattca ctaagccagg tcatttgttc tggattttgc 5521 tgactacaac cccatggttg tgtttaataa gttgctttct tccctgtact tcctgtaggt 5581 tgggtgttag atctagaggt ttaatcggat ttgatttgtg tttttggcaa gaacacttta 5641 taggtggcat tgtatacttc tgtaggaagg cattttgctt atctcttttt ttgtgatgtt 5701 agcagcaatt aattatcact gtctagaata ttttctttct tcatttttga tcacccctca
5761 acccaaccat caagttacac accccttcag accccctcct cacaccaact ctctcctttg
5821 tactgtttca actgattaga aaatgattta cttgaggccg ggtgtggtgg ctcatgcctg
5881 taatcccagc actttgggag gccaaggYgg gtggatcacc agaggtcagg agtttgagac
5941 cagcctggtc agtatggtga aaccctgtct caactaaaaa tacaaaaagt agccaggtgt
6001 ggtggcgcat gcctgtaatc ccagctactc tggaggctaa agcaggagaa tcacttgaac
6061 ctgggaggtg gaggttgcag tgagctgaga ttgcgccact gcactccagc ctaggcaaca
6121 agagtgaaac tccatctcaa aaaaaaaaaa aaagtaaaga aaaagaaaat ggttacttgg
6181 ttctaaattc atttcacaga tacagtctcc atgggaaata aacagaatgc tcattaacct
6241 tcagtgtatg tacatagagt tttctaagtt cccacttaca gcagctattt ttggctgtgt
6301 cctgttttaa gtgctggtag ggcctcctcc cactataggg gctgatcagc cactcactat
6361 ttgaagcctg ggtgttttct ggggagctct ttctcctcat cataatgagg acactcttgt
6421 cctttggcct tcaggtgatg tattaggaag ttattagagc tgcagtggcc ctcttctgac
6481 catagaggca agctttagga ttaaaaccga tgtgcccagg atgatgggtt gaaatgtgga
6541 aagagtctag gtcctcagta agacactgag tcactgaatt attaaatagg agaattggaa
6601 tttgtgaatt ttctctcttg caacaaaaca gttcccgagt ttcagactga atgtacaagc
6661 ttagcaagca gagccaacct gcaaatgccc tacctccaca cttcttattc taggggatta
6721 tgaatttaat ctactttagt tgattacttg cagctgcaaa caaccaagca gacacagtga
6781 ttaaatacaa ataaatctat tctatgtttc tgtttactat atatttaaag ctttgatgga
6841 gagaagaagc caatggaaac tgaccttgag ttttccataa aactgaactc ttccttgatg
6901 accctaatag agctaaaact atgattgaga ttgcacaaag cattgaatca tcaaaagtaa
6961 cgtattatga tgtcatatat taaataaact cagcttttgg taggatataa gttgaaaaag
7021 cacacagcaa cttaaaagtg gagatggagg cttagaaact tctatgttgg tgagaggagg
7081 tggaattaga atattttcca aggattattc tcaaagcaca taactgagaa ttgactttga
7141 gtgttggcaa taaaggaaga cttttctcct attacgatat gctagacata acattcttat
7201 taaagtaagg aggagaattg gagtttctga atctcctcct ttgcaacaaa acagctcccc
7261 tgtttcaaat tgaatgtaca agattagcaa gcagagagat gaagatttaa gaaaaaaagt
7321 atgggctggg tgcagtggct tacacctgta atcctagcac tttgggaggc cgaggctgga
7381 ggatggcttg agtctaggag gtcaagacca gcctgggcaa catagcaaga ccctatctct
7441 acaacaaata caaaaattcR ccgagtgtgg tggcgtgcac ctgtagtcct agggacttgg
7501 gaggctgaag tgggaggatt gcctgagtct gggaggtcaa ggctgcagtg tgctgtgatg
7561 gtgccactgc actctagctt ggacaacaga gcgagaccct gtctcaaaaa aaaaaaaaaa
7621 agaaagaaaa agaaaaaaag tatgatgttc aaaatctatt taagagggag ccatagagct
7681 tgagaaagca gaggatagct gatgatctgc cctgttcttg ctcctgcttc ttRtattttg
7741 cattcccaca ttgtgttgta tggaagcaaa acatcattgt tttactggtg agtagattgc
7801 acctttctcc ttgcagacaa ggtggtgaca gcaaccggtt ccaggaagcc cctgRtaaca
7861 acccttcttt gtgttgtgtg aggaagctat ggctcataag tgaMctcagc agatttccca
7921 cccactacgc tgggtccctc aactcacaga gactcattgt taagggcttt cactctgaac
7981 agctgctggc gcttgctggc ttcattcact atgaagatgg tgatcaaaca ccccagattt
8041 caaataatct gtcctatgat cagaccatgg gtcagcccat ttgccctggt gtctgattag
8101 gaaagtatga tcactgtcac catagaacaa cgcctcccaa cttctctacc cacttggatg
8161 ttttccccac tcacttcatt gttttggata tcactttaga ttgtggccct tctctttctg
8221 ccagaagcaa aattccccca tgtgtctaca gtagaaatgc cctctcttca gggatcatgc
8281 ctgaaattcc atttcgtcaa ttaaaattag acaaagtatg gcaggagcct agctcccttt
8341 gaaaagctac ctacctaatc agtattccaa gtgatttaaa cgtccattat cacaataaag
8401 ttcaaagcct ttaaagatgc atgaagtgat gcattcaagc aggtgaacat tacttgtctt
8461 ggaaaagtca ctggagggtg gaaggcaggg ttagggttca gcttttgaga ttagataaga
8521 gcaaagagca acttcaaaac tccctggggg caggcttgct gtcaccagtg gtggggcagg
8581 cagtgggctt actgttctct ctgacactgt ggcttgtgtg accagggcac agaatatgtc
8641 agaatcttgg gtatcttcta tggtacttag ccccgtgagt cagatacacc agaggtgctg
8701 aggggatgct tgtagactcg cttttacaga taactttcac gtagatctaa tgtgtgtggc
8761 acaccagatc gatgcatttg caaccacctt cctggtccac agcgtcaaaa catgcctgaa
8821 atgccaagaa gaatgtttgt atttgagcat aatttttcag ggaggcagKg ctttgatttt
8881 cctgattttt ttgtgtttca tttttttaac ctgactatgt agcaagaata ttagaaataa
8941 aatttaggag aggatagaca atccttgggt gtatggagac agggaatggc tcccggcagc
9001 tgaataaata gcatgcatgt atctggcttt ctgggcccta cccaagcctt tttacaacta
9061 ccaggtgttt tatagacaca tttttctatg aagtagtcaa actgtaaaca gcatgaatcc
9121 tgaatgataa tcgtgtctta ataataataa aagaaagaaa ataagagaca agcatcacga
9181 ttttcccaat tgaaatgtct tttggttttg cctttggtgg cacagggtca agggtgtggg
9241 ggcatttgtg tggcattcac tattctttca acctgtcctg attatggaac cctttaaggt
9301 ccgtccactt ggaaccacgg tgctctgaga ggacgctgaa ctcacagcag cccacacaca
9361 attccagtga tactactgca atgttttgta cacagaatct taggtttgtt gggtaaatgt
9421 agcatcatat tttgttttag caatttgtga acagtcttgc ttctcttcac acttataagY
9481 tcatcaggct aaggattaaa tcgtatgcac ccaaatacct cttagtatac aaacgtctgc
9541 actcagtagc gtttctggct gagcaggtgg aagaagggcc acgttcgcca atgtcatgag 9601 gggccagcat ctttaacctt cacgcccaca tcaccagcct tgccttcttc acaacagaaa
9661 tgttgtccca cttcctttcc aggtctctca gattcatggt acgagttgga aagagacctg
9721 agagattatt taggctaaac gtttcatttt ataaatgaca aaattagggt tgagcaaaat
9781 gtggtgattt tgtctgtgca aagccaagaa aaaaaattag agcctcttaa aagtcatttt
9841 tcccctgaaa taaagtatct tcatttcact gttaaatata tgtcctcatg tagttgctat
9901 aatcaaccac ttctcaagaa aactctaaaa gctgtatttc ccatatgaca catttcagaa
9961 tattacataa gaagctctca ccaagacacc aaggtaaaat atatatgaca agccaaagac
10021 aggtgccata aaaaaataag aaatcttcaa aggggaaaga aattccaaaa gtggcaacat
10081 gacaccactc attctctgcc tactttcgag gtaagacgat gttgaagttc tgagggggct
10141 cagtaaataa cacctctctt ccccctccag gtcctgcaca aattgaaaac ataaaaggta
10201 gcagatggac tcaaatgcca ccttcatgac tgaggtgcca agctggaggg caggagttgc
10261 cctctggtcc tggtttaggc tgaccttctg aacggggcct gagggcagga ccacacgggc
10321 agggatcaga aaggagctgg aggagagctc agaagggagg gcgggcccag ctctcttggc
10381 ggccaaggaa aaagcctggc atgttagagc tggtgcagga ctctccaggg tgaccgagcc
10441 acccagaaga gggaaaagcc attctccata acaaaaagtc aggaccggct gaaagcccct
10501 cccagccctc caccctcctt cggcggggct tctttctgag ctttgcccca tccctgcccc
10561 gtgctggtga ctggtgtttg gctccctcct agagaaagag atgggcctgg gttggttgag
10621 agagaaagag agagaaaggg agagacagag agaaggctta gctcttgtcc aacagggcca
10681 cctagaggga ctctcaggct tgagcgggag aagcagagtt ttgaggcaga gctgatcaag
10741 ggaacctcaa caaacaaccc cagccatgga ggcggcggtg tctttgaaga ccccatgaga
10801 gcatcaaaca agggagagag gtaactttaa ataccacaac ctagcccagg aagaaagaat
10861 gggccctctg agacgatcaa ttaattaaga gcttttctcc ctttctccct cctcctcctc
10921 ctccctcttc ctgctttgag cctggaacaa atcatggtag taaaatggcg gcagagagct
10981 agtaatgtgt ctgcaattgg tgggttcttg gtcgcactga cttcaagaat gaagccgcgg
11041 accctcacgg tgagtgttac aattcttaaa agtggcgtgt ccggaatttg ttccttctga
11101 tgttcggagt ttcttccttc tggtgggttc gtggtctcgc tggctcagga gtgaagctgc
11161 agaccttcgc agtgagcgtt acagctctta aggtggtgtt tctggagttg ttcgttcctt
11221 ccggtggctt catagtctcg ctggctcagg agtgaagctg cagaccttcg cagtgagcgt
11281 tacagctctt aaggtggtgt ttctggagtt gttcgttcct tccggtggct tcatagtctc
11341 gctggcttca ggagtgaagc tgcagacctt cctggtgagt gttacagctc ttaaggcggt
11401 gcgtctggag ttgttcgttt ctcccggtgg gttcgtggtc tcgctggctt taagagtgaa
11461 gctgcagacc ttcacggtga atgttacagc tcataaaggc agtgtggacc taaagagtga
11521 gcagcagcaa gatttattgc aaagagagga agaataaggc ttccacagtg tgcaagggga
11581 ccccaacagg ttgccaccgc tggcttgggc agcctgcttt tattgtctta tctggcccca
11641 ctgacatcct gctgattggt ccattttaca gagagccgag tggtctgttt tgacagggtg
11701 ctgattggtg cgtttacaat ccctgagcta gacacaaagg ttctccacct ccccaccaga
11761 gtagctagat acagaatgtt gattggtgca ttcacgaacc ctgagctaga cagagggtgc
11821 tgattggtgt gtctacaaac cttgagctag atacagagtg ccgattggtg tatttacaat
11881 cccttagcta gacataaggg ttctccaagt ccccaccaga gtagctagat acagtgtcga
11941 ttggtgcatt cacaaaccgt gagctagaca gagggtgctg attggtgtgt ttacaaacct
12001 tgagctagat acagagtgct gattggtgta tttacaatcc cttagctaga cataaacgtt
12061 ctccaagtcc ccaccacact caggagccca gctggcttca cccagtggat catgcaccca
12121 ggccacaggt ggagctgcct gccagtccca cgctgtgcgc ctgcactcct cagcccttgg
12181 gtggtcgatg ggactgggca ccgtagagca gtgggcggcg ctcgtcggag aggctctggc
12241 cgcgcaggag cccatggagg ccggtggggg aggctcaggc atggcgggct gcaggtcccc
12301 agccctgccc ggcgggaagg cagctaaggc ccggggagaa attgaccaca gcagctgctg
12361 gcccagatgc taagcccctc actgcccggg gccgcagccg ctccgagtgc cgggcccgcc
12421 aagcccacac ccacccggaa ctggcactgg ccctggccca caagcacagt gcgcagcccc
12481 ggttcctgcc cctgcctctc cctcctcacc tccccgcaag cttagggagc cggctccggc
12541 cttggccagc ccagaaaggg gctcccacag tgcagcggtg ggctgaaggg ctcctcaagt
12601 gccgccaaag tgggagccca ggcagaggag gtgcggagag cgagccaggg ctgtgaggac
12661 tgccagcacg ctgtcacctt tcagtaggtg gacgacaaga aaagatgtct cccgcccctc
12721 tttacctggc ttcctggctg cagaaggccc cacacaggtg aagggagaag cttcaacttg
12781 aaatctggtt ttaagaattg attatgggcc aggagctgtg gctcacccct gtaatcccag
12841 cactttggga ggccgaagtg ggcggatcaa gaggtcagga gattgagacc atcctggcca
12901 acttggtgaa accctgtctc tactaaaaat acaaacaatt agccgggcgt ggtggcaggc
12961 gcctgtagtc ccagctactc gggaggctga ggcaggagaa ttgcttgaac ccgggacgcg
13021 gaggttgcag tgagccgaga tagcgccact gcactccagc ctgggcgacg gagcgagact
13081 tcatctaaaa aaaaaaaaat tgattatgac acaaaactag atattctaac ttctcagttg
13141 agactgttgg agacttagag tgactatagg actttttatt acttaagagt gattaaaacg
13201 agttgtaaga ttatggagat tttcattctg gagcaagaga agaacttttc ccctattgag
13261 taatctgaaa aggacagcgg gaatcaaaaa caaggttgct ttctcctttg aatatattgt
13321 tttcttcttc aaatctaaaa atctgttgat ttcatgtttt cccttttatt tctctaaccc
13381 actgaaatgt gattgcttct ggtatcccta agtttatcaa gcatactact aaaccagcat
13441 ttgggacatt aagaacactg gacactccaa ctaaccaggg gctgaatcct actgactgca 13501 ctcgctatgt tttgtccagg tggcacggtg cctgggaagc aactgcaggg ctgttcctcc
13561 agcagtttat gaactcaaga agtaaaatga gaggagaacc cagggggcac caggctgctg
13621 cctcttggtt ttggttcaaa aaaaaagaaa agaagaacaa tgataaatgt attacagtca
13681 gtaaccgttt ctgatttaca ctcaaggtgg tcttgctatg atctcaaagc gctcttccag
13741 caaacagcac tgctattaaa acctgttggt gatacaaatt gtttaagaat aaaaatcggc
13801 tgggtgtggt ggctcacacY tgtaatccta gcactttggg atgctgaggc gggtggatca
13861 cctgaggtca ggcgttcaag accagcctgg ccaagattgt gaaacacctt ctctactaaa 13921 aatacaaaaa tacaaaaatt agccaggcat ggtgacgggc acctgtaatc ccagctactc 13981 gggaggctga ggcaaagaat tgcttgaacc tgggaggcgg agtttgcagt gagctgagat 14041 tgcaccactg cactccagcc tgggcgacag agcaagactc tgtctcaaaa aaaaaaagaa 14101 taaaaattaa aaacacacac aagaaaacaa agtaaaactt gttggtgagt aaaccgaatg 14161 aaatatgtta aatctctgtc caatcctgtc caaagtcagg cagaggaggc caacttgagt 14221 acttatcacc atctcccagc accttttgtt gtttgattag aatagattcc ctctgtaaga 14281 cattaatgat ttccaaggct gctttaagaa gtttctttgt tatacgggaa gtgattgaga 14341 actggcaatc atgaatctgg ctgtctctgc tcaggagctt aaagactgtt ctgatgacga 14401 taattacatt tttatgaata tcctgcctag agagtaacaa ttttactatg tcaaaccgca 14461 ccacacaaag atgcatcaat ttcatctgca atgaaaaata gagcctaata gtacagttat 14521 atttatatga tagtcaaaca tcaagatgta acgtaagtgc ttcaactaaa agaattccga 14581 tcattattta accttgagat gattaaggtg aaagcttgtc agcttccatg aattactttt 14641 ttcatgattt ttgctgtttt ggtttgattt ttaaaaatcc ataattaaca tttattaaca 14701 tttggattct actccaacct ccatgatgtg tgggcaaggg aaaaacaaca acaaaaaaga 14761 tccatagata tgattaatgg tcaaagagag agtattaggt aattataagt cataattatg 14821 ttcttggtaa aataccatac taactggttt tctcctttct ccttttctct gctaagtttc 14881 ttcaactata atgcaaatta tggacaatgt atttaggtta gatgctatac atacatatta
14941 atttaataca aagaaaactg tttcattgtg attgtgcacc agagctatgc caagtgtggt 15001 ctgagaacca gcaacattaa gcattactca aaaacctgtt ggaaatgcaa attctcaggc 15061 gttaccccag atctcttgaa tccgaatctg tagcagtggg cacaggcccc cgggactctg 15121 tgttaacaag ccttccagga ggtgcgatga gRtgtgagaa tcactgctcc agcatcttgt 15181 aactcattct cccctggcta aagtgaaaca taggtaagtg tggaggctgc aatcccagca 15241 acgctgtacg tgttccctgt tagctggagg agggggcatg tgttcctaga aagggggccc 15301 aagcgaacag cctgttttgg ccacgtctct tgagtccagg ttcctctcca ttgggttttc 15361 tcttctcttt aaatctcctg aggtcccagt gtgccccagg ccatagtttc ttcccattac 15421 cagtcatagt tgttgtttaa cctctgtggt aggaggggtg tttatgatac tcctcatcat 15481 gtgaggactt ccaccactct gaagcaccct gttggtgctt cccctctatc actgagactt 15541 catttccttg acatcatctt gagctgctta aacatttttc tttttcccag acggagtctt 15601 gctgttttgc ccaggctgga gtgcagtgac atgatttcag ctcactgcaa cctccgcctc 15661 ctgggttcaa ggaattatcc tgcctcaacc tcccgagtag ctgagattac aggtgcccgc 15721 caccacaccc gggtaatttt tatattttta gtagagacaa ggtttcacca tgttggccag 15781 gctggtcttg aactcctgac ctcgtgatct gcccaccttg gcctcccaaa gtgtgcttaa 15841 acatttttaa catccgccgt gatactcttc tatttttctt tatggcagaa gtaacactat 15901 ttaccttttg acagcacaat ggaccaaaat tgtttaccag aactcaccag aaagtggcat 15961 ggagaggggc cacacattgc caacacactg aaagaaacgc agtagaacac acactcagta 16021 cagagtgctg atgctccctg gccgggaccg cacagtgctg ttaccgtagg agttttcttt 16081 ggcagagagg atagggtagc acgtagcatg agggaaaagt gtcatcagaa tttggtgaca 16141 gatagataga cagatataga gatatttttt attgtggtaa gaacataaca aaactcacca 16201 tcttaaatat ttgtaagtgt atggtgaata gtgttaagta tattcacacc gttgtgaaac 16261 agatctccaa actttttaat cttgtaaaac tgacactcta taccttttaa acaactccca 16321 cttcccccct acccttagcc cctggcaacc accattttac tttctgtttc tatgaattcg 16381 attactttag atagctcata aaaatgaaat catccaggca ggtgcagtgg ctcacacctg 16441 taatcctagc actttgggag gccgaggcag gaggattgct tgagcccagg agtttgagac 16501 cagctgggca acacagtgag atccccatct ctgttattaa aaaaaaaaaa gaatcactca 16561 gtatttgtct tttcttgaat ggcttatttc acttagcata atgtcctcaa ggtttaccta 16621 atagaaacat ttttgaagga acgcatattc gagacaatag cattctaatg aatcagcaca 16681 catgggacag tgttaaatga agtgaatcag tatgacaaaa agtgaacacc atcttggtga 16741 tttaatcttc gtattatttc atatattctt ttttgtttta atttatgcag gcttggctgg 16801 gtttggtggg tcatgcctgt aatcccacca ctttgagagg ccaaggcggg tggatcattt 16861 gaggtcagga gttccagccc agcctgccca acatggtgaa accctgcttc tactaaaaat 16921 acaaaaatta gccaggtgtg gtggcatgta cctgtaatct cagctactca ggaggatgag 16981 gcaggagaat tgcttgaacc cagcaggcgg aggttgcagt gatcccagat tgcatcactg 17041 cactccagcc tgggcgacac agagagactt tgtctcaaaa ataaataaat aaataaaaat 17101 aaaaatgaaa tggatgcagg ctccatcgtc tatggagatg gactcatcca cattatttca 17161 tatatgctat atattttaat actttttttg ttttattttt tagtccaggt tccaggctta 17221 tgaatacatt gttttagagg cccagtgcaa gggcaaaatc tttagagtgg tgcttctgaa 17281 atctgagtgt gaatcagaat gaccttgaaa tttgttaaaa atacaaattc cctgggttcc 17341 aagagattct aattttggta ggtctgaggt ggagcccagg aatcagcatt taacaagcac 17401 tccaggtgat tctttccttc tgagagacac tgcaagtcta aatcagcagg gtagagcagt 17461 gcctttgagg gtgaagcagt gaggctcaac ccctttcaca ggtgttgtac cttctttgga 17521 tcctcctgat gcattgtatc tggactttga ataacaatta atgtactctg cctagttcta
17581 gagtttctca tgtccttgcc tcagccccgc ccaaagacca caggcttcct gagacacagg 17641 cattttgcag tattgacctg catatcctca gctgggttta cctcacgccg tctctgttgt 17701 gagaagatgc gcRataatat ttgtcaaatg aatgaagaca ataaggacag aaatccaatg 17761 aaaagaatgt gactgaaaga gtcagagagg aatttagtct tggYctgtga gcccaacagc 17821 tgtgaggcct taagttactt cctctctcag gccttagccc tgtacctgtg acatggggat 17881 cagtttcttc ctccttcctc tttctgaggg ctgctgtggg gtacaaatga cataaggtat 17941 gtaaaaatgc ctgaaaactg tggagccact cttttcaatt ttgttgaata tgattgtctt 18001 tttgctttac tgagtgttag gtagtatgat gaggcaaaga acacaaggtt tacttctggc 18061 tattaccgaa aagcgaatcc tattatttgg tatttaaaag agccacatgg cttttccaac 18121 tccaaggaga gtgacaaaga aatttagtac tataaattta tgataggaat ggtagaaata 18181 tcctataaat aatgaacagt acaaaggaag ggagattcaY aggaaagcaa attaactagg 18241 cacactgcag tttgattctg acatggggat ttcccgtaac ctgtaactgc ttaatgaaat 18301 gacttctggc ttctctgaga tcaccttaaa aggtagcagg tatctgataa gatgagctga 18361 aaagcaaatt tatataatat cctttttaaa acttcaaggc agggattata accaccccct 18421 aaactgcaaa gaaccaaaag aagttggatc acatccaaga agcaatgtgt cccaggtggt 18481 aaacgcagag ccagtccaca gtccaatgag gaaagtgagg acaacggagc aagttttcca 18541 ggaagctatg tttattcagt tgagccaact gcctcattct caaatgaggt cttccattgt 18601 cttggctcac taaggttctt acttatagga aatatcggta tttttttaaa ctgacaaatg 18661 aaaagttgac aatgatatta ctccccattc aaatttgatc aggcagcttt gagtttgaat 18721 tctcaatcca cttaaggcaa gtggcttgag gcaaatttct aatccactca ggctttgatt 18781 tctctatgta taatgataca aagattggca ataatatttg taaaaagcct agctcaaatt 18841 gtagtattgg tggtggttat atgaaaaaga atgtgttgtc atttagatac ataaattagg 18901 cagtgtcttc tttttaaaat tttttttatt gttttaagag atggggtctc tggcacccaa 18961 gctggagtgc agtggaagga tcatagctca ttgcaacctc aaactcctgg gctcaagtga 19021 tcctcctgcc tcagcctcct gagtagctag gagtataggc acatgccacc atgcccggct 19081 aaYttttaaa atttatttga gacagggtct ggctatgttg tcSaggctgg tcttgaattc 19141 cagggctcaa acaatcctcc cacctcagcc tcccaaagtc ttgggaatac aggtgtgagc 19201 cactgtgcct ggccatggta gcttgtcttg atggtataaa attactgttt tcattactgt 19261 gttagatgtt ttttcatttt cccatggtgg cctcctttgg gactgtccat gcttttgctc 19321 caagagtaaa tctcaaagga gcaagcatga gtaggaattt tccttgcatg cacacagcca 19381 gccaaacagc cctatgtccg tgatgaggtg cattccagaa ccagtggtag gatggggttg 19441 ggttgtacct actagctgaa gtttttatta gatgtagaat ttaaactcac acttggttct 19501 gggtctagta tttaaaaact tcctattgta ttatgtatat ctttgtattc ctagtgctta 19561 ataaattata gttcctcaac tactgtttgt tgatgatttg aataNtgtac aaataaatat 19621 cagggagtac aacagctcca ttaaatcatg tgggtttttc caattatttg ctgctatttg 19681 tttctggaac tgatctgaaa tagatagcat tttgatgtgt gacctttaac ttaccaaggc 19741 agacagaaaa caggaaaagg gtgggagtcc ctatgactaa aacgtttatg ttaagtccat 19801 gatggatatt ccaggtgttc tggtaggcat cttcctggcc aaaatttaag ctgaatttga 19861 gcgcaacgtc taataacggc tggacttgtt ttccagggac ctcaaaggta ttttcttaga 19921 taggtcatgt tctggggctt ttgactctaa tgcaatgtgg gcaatgcaat gaccatgtta 19981 ttttagagac atttacaggt cactcaggga gtatgaagga ggcaaacact ttggctctct 20041 tatatctgtc actcacagga agctggtggc ttaaagtttt taagacattt gttttggttg 20101 agttctccac cagaagttga gcaaggcaga attgcaaggg caggtccagg ttttgtgatg 20161 tctgaagctt tagacaatat aagttgtcct atttaagaaa gataatataa aatcataaat 20221 aaaaaactag atatgaaaat gagtatKtaa cttgaagccc cagctaggca cagtgtctca 20281 cacctgtaat ccttgcacat taggaggctg aggtgggagc cttgctcgag gccaggaatt 20341 tgagactagc ctgggcaata tggcgagacc acccctcttt acaaaaaaaa aattaaaaat 20401 tagccaggca tggttgcgca cctgtagtca gtcccagtga ctcaggaggc tgaggcagga 20461 ggattgcttg aactcaggaa tctgaggctg cagtgagcta tgataatgcc actgcactcc 20521 agcctgggtg acagaatgag accctttaaa ataaaaataa taataaatag ttagaagcca 20581 accccccccc cNccgccttg caactggggg atcctacagc ttgagcttaa ttagcttctt 20641 ataaatgcac ctgtgtaata atggaagcaa cattttaaga caaaggtact tgtgctataa 20701 cgttgatgag tgggacattt ctaaacattt accagtatga gaaacacgta catgctaaat 20761 gtaactcgac atagacatta aatgccaagt gttcaggctg cagggaagtg agactggggg 20821 aagacaaagg agaagggaac tggtgactat taggtaccca gggagccttc agttagttgg 20881 aatgtttaga aaactgggaa tccttgaatt taccttccaa attaatcaaa acccaaaaga 20941 tataacttat tggtcatcaa aaatctttcc aaatactgtt tttttcaagg ttcctgtagg 21001 tttaacaatt tttaaaaagc gagtgtaatt taccatgaca ttgagattag aaagaaagca 21061 aataaattac ttaagggggt aagaacctat aaaatatgtg tcttctccac tagtagcaag 21121 ccctctatgg cttgggtgac tgaagttgcc cccatgcctg tttggaatgg gtgctggcct 21181 ccttacctgc cactcagaga tcacttgacc actacagtca cggtggggat accagttaat 21241 aggtcatttg tggtgaagct ggtaaacagt aagtgctcaa taaaaactta ttaaatgaat 21301 gaatcaaata aataattcca ctttgaacaa acgaggccag acttaaagca atttttattc
21361 ctaaagattc tgcaactgaa ttttgtcaag acttctttat ttatttattt atttattatt
21421 attatacttt aagttttagg gtacatgtgc acaatgtgca ggttagttac atatgtatac
21481 atgtgccatg ctggtgtgct gcacccacta actcgtcatc tagcattagg tatatctaaa
21541 aatatggaac gcttcacgaa tttgcgtgtc atccttgcgc aggggccatg ctaatcttct
21601 ctgtatcgtt ccaattttag tatatgtgct gccgaagcga gcacttgtca agacttcttt
21661 gcgtttgaga attctgtcat gaatatggcc taggtttgat ggcaaaatga ttaagaaatg
21721 aaatggagtt aattttcatt gagtgcctaa catatgccag gtatcttgct tgagttttgc
21781 atatttactt atttatttta aaatttattt tttttcaata aaccacctac aaagcttctg
21841 gatgtgtatt atttaagctt tgtaaccatt ttgcacttga ggaagctaga actcagactt
21901 aaataaYttg tctatggcct cacagggagc aagtggcaga gccagaatcc aaacgcagat
21961 ttgtgagtgc acggcttttg ctgtgacgct gtaacctctc atttggcctg ttctttccag
22021 ccaatgtgaa agacacataa aacagtgata gagagagggg caggaaagac tatgaagatg
22081 ggacagtaca gtgagaagtc acatcattta gggccttaaa ttgcccatct gtaagcccag
22141 acgtttggac tggatgacct ctgagtgggg tgaccacacg gccccatttt ccaaggcaac
22201 ccagacttat acctgctttg ccactgcaac tattagcacc ccttccactc tcaaaaatgt
22261 tccattgtgg atcataaatt ctaaggttgc cccatctgcg aagttctggc tcttaatttc
22321 tgttatttca tactgaacct aataatactt ctctgatgac tgaagcacgg taaaatttca
22381 ttttccaggc ctggaggtac agggaggatg gtaggtgagg tgacccttat gtagaagttg
22441 ctttgcattt ctgatatgga tattttttca atctaggagc tagtgctcct ttcctttaaa
22501 agtacactag tagatcccct tctagtggat ttggctccag ttaatttggg atcattatat
22561 aaatatttgt ttcctacttc acactaatag tggctactcc ttattgagtg cttacactaa
22621 ggctaaatgc tgagtgcatt atctcattta atgcatatat taatgctata agatagttcc
22681 tcaccttata gataaggaaa caggtttagt gaagtgactt gcaagtaaga cacggagcca
22741 ggtcttccta agctcttagc cattcttcta tattgagatc tgtatgtata catacagcag
22801 ataattaaga aagttatcag actcctaaat tcccattggc ctttcctgta tttatcagta
22861 tccatgccag tctttgtaat ttcatcttcc attgcttcag ccatccatct ttacctccta
22921 gtacaaacat ctgcctcaag taaacagatt ttgactaaga tgcagattct cggaaaaaac
22981 gaagatggga ttagcaagta ggtacaatga atatttactt acttatacaa accttttttt
23041 gtttgtcttt cttttccaca gtttaaaacc gaaaacagac acttgttttt ttgtttatat
23101 ttacataaac aatacttaaa agaaaaacca ccagttgaca ccatatcatt ctgcttttct
23161 ttattgtctg gctaacttac aaagatgcag atgtctaggg tagtctctac cctaccactt
23221 acactatcct gatgacacag atagcaaaat gtgtctgttt acatagtgca tgRtatgaaa
23281 aaaaagtttt tcttcctcKa cggtccttga ctataaggag ggaaaaatta atttcatgcc
23341 aacatttttg gggaacttta acaatcatcc catttctgct actaaaataa caaaactggt
23401 attacacttt aaaatataaa gacctaacag tttttacaaa tatgcaaata atctactact
23461 tagacataaa aaaaagttga tttcttttaa atcacaaagt aaggcaccat tggattaaac
23521 atttctcctg gcttttacta aataaaatgc atagtgaaat aaatactgaa cactgagttt
23581 taatactgta atacatttca atataaaata agaggtgaat gtKaaaatac tgtattacat
23641 gttgaataca tttatctgaa aatgttatWa aaaaacacac atgtaagctc tgatttcagg
23701 gaagaaaaat tcatttttgt aattttccat agtttaagat tttaccacag aacttattca
23761 tagttttaga tgcaattagg ttgcaaactt tcaaagaaag ggtgtaggtg tattaatgaa
23821 acagtcactt aaacactaca ttcWaaaaca atctattctg gatgaatggc aactttgagc
23881 tatcaccctg tttcagattt agaacggtac ctgccaagtt cagatatgca aaggaattgt
23941 ccaattctta ctacccctta taaaattcag acccactttc tctgagtcag acttttctcc
24001 gtcatatttt ctaggaaggg caaattccat cttttgtgaa atgggtcatt aggctttatc
24061 atagggatgt ttttcactgt tgaaatcaga taaaagaatc ccaaataaat gatgctgcta
24121 aattaccaaa ctgctagaga ttaaaaaaat ttttttttaa aaagccaaca ctttgccaag
24181 cttgttataY cttattattt cttgattctc tttgagtaaa aagcccaaat gactgtatgg
24241 aagagagatg aatggtagag gagagaggaa acacaggttc tctaatgtac taaatcagga
24301 ctttggcaag gaagttatag aaatataata tattcaaatc agtaacttca taatttatta
24361 gacatcccat ttattagaac tctaagttct tttgctttta tataaatgaa acatttattc
24421 tataaataga aatgtatttt tcagaatttt ctttgggttg gtttcttggt agcatctccc
24481 agtaaYacat gaataacata ctgaaaccat gatacaatgt ttaggtagat atacatatac
24541 atatgtggtc atgtgttttt aaaaaacaag taatggtaat tttaaacaaa accatgtaaa
24601 atatctaagt ggaaatattt tttcccaact ctatagctag atttaaaagt cccagtaaaa
24661 ttttgtaaac aaaatcatat aagaaaaggc aaggctggct cttccctatg gtcctttagt
24721 ggagctatat ttgcatagat cctagacaaa tgatgcaaaa caaattccct ccaatttcca
24781 ctagcaatct ccctaattcg ctcaaccctt acataagcat cagatttaga tttttagagt
24841 tttgcccacc aactcaaatc ggttcccttc ttcttccatg tttctgattt gatatMtttt
24901 cctgactttt ttcccctcct accaagcctt cctagtctct cccagcctca ggagcttgct
24961 cagccagaaa ggaacaaagg ctgcttccat ttcacaaggc agaagtccag ctgacaagtg
25021 gagtgcgtga gccagctggt tctgagccca gaagtcccga caggctttcc atttgtttcc
25081 aatggcttta ttccacatga ctttagtaaa ccgtactSaa tcaatttctg accttggtac
25141 tttgaagcaa cacttgtata cagatattaa gggaagaggg aagttaaggg aggaaaatcg 25201 aaggtcaaac tgtgtgtcaa acaaggtgct gggtcctaat tttattttta gttgcctctt
25261 gaatcgctca agcccatctt gccttttttg ttttttaaac aagaggtttc tgcactagct
25321 tccatcttcc agactcgtgc tgtctaatcc agtagccacc agccacatgt ggctactgag
25381 cacttaaaaa tgtgactagt ctgaatggag atgtgcggta agtgtaaaat acactctgga
25441 ttttgaagat tcagtaccaa aaaataatat aaaatatctc attaaaattt tatgttgatt
25501 acaggttgaa atattttgga tgcatattaa cttcacttgt ttaaaatata ttagaaatgt
25561 aaaaattgta tatggggctc acattatatt tctattggac agctctgtcc tagagccaag
25621 ctcggactgc caaagattgg acatcctgtg actgcaagtt tccagtgagc ccttactcag
25681 cagcttgctt aggtggtctg tggttcatag aaacagagag gaggccaagc atgcgaaaaa
25741 ggaacgggag aaaacagctc tcagggactt taataattac agtctgtaac aaataagcag
25801 tgaatgtttg aatttggttg gtggaaagct gggatgcaag tcatctctgc ctattacgac
25861 aaaagcctat cgaccccagc agccagcaca ggcaggctgc agctgaagca agcaatagcc
25921 tggagaataa acacaatatg aaaagctagg tgcatttctt accgattccc acccacacac
25981 gcatattccc actccccctc ccacctttcc tcctgcccat acatgaggca caagggaaga
26041 agcagggagg agggtatgca gttcttagat agcaacagaa gcagctcttg agcttgggta
26101 gagaagagca ggcaaagatc acctcgggat gggagggagt ggtggagcac ccctttctct
26161 tcggttggat ccaccttggt gaaaaaacag acaaaatata attttggtta gaaagctgat
26221 gttctcatcg tggaaactcg gggatggttg cacgggtacc cactacctca tccctatgac
26281 cagggctgtc agctaactgg cgtatgttgt ggatgagaag tgagaggtga aaacaagcaa
26341 gtaatgttct gaataaacat catggtgggt gatccatcac tggctcccaa gtacttgcac
26401 aaagttaaaa aaaatcattt tcttcttatc acagtgtgtg cttattatag atttagaaaa
26461 tatggatgag taaaaacaaa gaactcaccc attcctccag cacccagaga taaccaatta
26521 tgtgtatatt ttttacttag aaacagttcc ccgttttctt ccagaaataa gatcatatag
26581 tcagtttgaa catctttcga aggcattact ctttgcaaag attattaatg acagtctgca
26641 ttccaaaata tgactacact acagtctacc tagtcaattc ccttttgttg ggcatttagg
26701 tatcttctaa ttaaaaatta gaaagctttt ctgacagtag ccattctaat gggtgtaaag
26761 ttgtatctca ctatagtttt atttgcagtt tcataaaagt tagtgatgtt gaacaccttt
26821 tcaagtactc tgtcgatgtg ttcttttaaa agttattcac ggcccagttg cagtggctca
26881 cgcctgtaac cccagcactt tgagaggttg aggagggatg atggcttgag ctcaggagtt
26941 tgagaccagt ctgggcaaca tagcaaaacc ctgtctccac aaaaattagc cgggcatgtt
27001 ggtgtgcgcc tgtcccatag tcccagctac ctgggaggct gtggtgggag gatcacctga
27061 acctgagagg tcgaggctgc aatgagccaa gattgcgcca ctgcactcca gcctgggtga
27121 cagagtgaga ccctgtctca aaaacaaaat aaaaaccaaa accaagctat tcatgggcta
27181 tcagtccact gtaactaggc ttaaaaccca ttcacataaa aaaaattcat ttactacaca
27241 aacatttgtt gaggatttaa caggtgtttg gcatgaggtc aggtgctcag atgttgtgaa
27301 caggtctaac tggggcatgt gtcaatcagg taggtctgct ctaaccactg ctctgagact
27361 cagtgggctg gaactggcag attcctcaag taggcatctt gatagggacc ctactggtcc
27421 acttagggat ttctgagaaa gaaccaaatt tctgagcaag gaagggagtt aggagaaaac
27481 actgaaagaa gcacctcttc ctctcaccat cccaaccaaa tattttcttg ggcaggcatc
27541 tgagaaaaga ctcatctgga tgtaaaccag acacctatca tggggccttg accatcaact
27601 gacccgccac aagtggttag tagaatgagg gctggccttg tccaaagctg taattagagg
27661 gcactccaag tgcattcggt actgctcagg gctgtctggg tgcgctctca ggctgtgggc
27721 ttggaggctg aggctgctgc agagcagagg aaaacttggt actcgacggt gccttattta
27781 tttttgttag atgatccatt atcattataa aatattaaac atgcctaatg ctggaaatat
27841 ttaaggcaaa tctacaaaaa aattttggta gactgtggaa attaattcac caatttaaaa
27901 actactttta ggcgaggcat ggtagctcat gcctataatc cagtgctttg ggaggttaag
27961 gcaggggact acttgaggcc agaagctcaa gaccagcctg ggtgacatag agatatcctg
28021 tctctataag aaaattttta aaaagaaata cttgaaaatg ccctttatgt ttcaggctct
28081 gtgcccctca aggaaggtgc aatagtgagc aggacacagt tctagtcctt acattgccta
28141 ctcaagtctt aaaggaggat gggagaagat atatgcttag ctattccatt aaagatctag
28201 agggtacagg gaagatggtc tattaccaat ttaaaaatag aaataatatt tagaataaga
28261 agcaaataat aagttaggaa aaatatttgg agtctatatg aacaactcct taaagtcaat
28321 tcatttattg gtgcccaaga aggaagaagg gctgtactct tatcaaacag aagcccttct
28381 tctggtgcac acacacacac acacacacac acacacacac acaccattca aagatatctg
28441 tcccatgtga aaacttactt ttcactaaca cttttttttt ttttttgaga tggagtttcg
28501 ctctcgttgc ccaggctcaa gtgcaatggc gacttctgct caccgcaacc tccacctcct
28561 gagttcaagc aattctcctg cctcagcctc ctgagtagct gggattacac gcatgcgccc
28621 ctatgcccgg ctaattttgt atttttagta gagacaggtt ttctccatgt tggtcaggct
28681 agtctcgaac tcctgacctc aggtgatctg cccacctcag cctcccaaag tgctgggatt
28741 acaggcgtga gccaccgtgc ctggccttca ctaaaaattt caatcatcaa ctcttgtata
28801 ataattttat tatagctata cttcttcatt aggtattgtc tatgaatgca gtcttccaca
28861 gaaaσaaatc ttttcaggaa ttaaagtttt ccttttaagc agtagtattc tgttttcttc
28921 tagcatttgt ccatggaaat tttcctatat tttctaactc tttaaatttt tctacagagg
28981 cacaaagcac agtttgactc aattaattta attccattta acccaataga aattcaaccc
29041 aacagaaaca tctggtgttg tcctgcgctg tgacacacag cacagccatg ttcctgtctc 29101 ctcctctgac ctgggactgc catctgtcac ttctctccca tgtcagtgat tttgcttctc 29161 accagtctta actttagctg ttattaatct cctataaggt ttggaaccaa ccaaccaaaa 29221 attactttaa actgtgttag gaaagaatca gtaggctttg agtacatgta aggtgctctg 29281 ttagggagtg gggccatcgc taggggtgtt gtgacatatt tgacttgttt gcttaagttt 29341 tctctatttc tggtttggga atttggctct gaggctaagg ctgccacgaa cctcagcctc 29401 atggatgaca tatgcatatt tcatgctaat tctttcttcg ttgtatacat ttttttttat 29461 ttttattttt tttgagatga agtctcgctc tgtcgcccag gctggagtgc aatggcgcaa 29521 tctcagctca gtgcaacctc tgcatcccgg gttctagtga ttctcctgcc tcagcctcct 29581 gagtagctgg gattacaggc acacaccacc atgcccagct aatttttgta tttttatatt 29641 tttagtagag atggggtttc accatgttgg tcaggctggt ctcgaactcc tgacctcgtg 29701 atccgcccac ctcagcctcc caaagtgctg ggattacagg cgtgagccac catgcccagc 29761 tattgtgttt ttttaaaagt aaatttcaga ggctttccag caaaaccctg gaaagcctgc 29821 tagacaaatt ctcaaagagc tgtaacactt cctatacatt tactgttata aaattccagt 29881 ttgtctattt ttcctttctt gttgacattc ttcttcaatg gaggaaaagc aatttagttc 29941 tttatggtag cattacctac attagcagaa caacagaaat aatttaaatg tccatggtaa 30001 tggtaaatta ctatatgctg aaataaaaac catgtgataa catgggcact atttactaag 30O61 caatgttatg taaaccccgc caaaaaactg tacatcgtca ttataactac ataaaaaaac 30121 agaattatat ggataaaaaa ttggatgaga atctggtaaa atgaaaatat ctattatgtg 30181 gagagattat ggatatattt acattttcat gtaatgctct gtaaagctat gattacaata 30241 cgtttaaaag atcaaggcag ttaaagggag tttttgttat aattaatcag acattatgcc 30301 aatttcaaaa ctagaaggaa tagaagatgg ctctacttgt gctgtctcag gaagatgaaa 30361 acagaggaag acgtccaaag aagtaaaata ataaaattta atactagcaa accacggtat 30421 tttgagcttg taatgacaca ttaaaataac tgtttctcat atgcattctg ggcatctgca 30481 atttcctcac tgcctgtgga aggggaattt actagaatgt agatggctcc aaagggttct 30541 ctaccccact Scaggcaaga agcctggact ttctatatag cccgagtgtc actcaggcta 30601 ctcaagcgtg aatcttcaaa aaccttggca gaaatactca ctccggcttt cgtttcttgc 30661 cagtttgctg ggataacttt tggtcgtttg tacatatggc tctggaggtg gcaaatcgga 30721 aatcggatgg aagtagaatc tgctttccca ctcatctggg aagagaaaca agcagtatct 30781 tcagtgacag acaatgtgct atgaagactt acgtaacgaa aggcacagaa tgaaagagag 30841 agaNaaccac agacatcagt gctagttttt atgcctagaa gtttacagaa aagctggaaR 30901 tgctacaaag gtcacgaatt agtacactga catatataca gRcctgcaaa tcaaagcaaa 30961 gtggttttag tgagagtgat taggatccag ccagtccctc ttaggagctg ggggctaagg 31021 tatgggacac ctttttcccc attgataaca atggcagaga taggcaactt agtatctgca 31081 ggccgtcagg cctcttacct acagtgaact gtttagaaat gtacataata agaagctata 31141 aaaagattct tttcagaatc ctggaatctc tggaaagtta actaaaatga gacccaaaca 31201 aagaacagat cagggaaaaa tgatccgcct ttttgggaag tggggaaggg ggattactat 31261 ttttaatttg aaatcatggt gggccttaga atggttagat agttagatca gtgcaatgga 31321 gtgtgataat gatggaacaa gaaattaaac gcaaacaagc aaaccacata tacaaacaga 31381 tttaccattt agttgctgcc ctatagccca gggagctggg accacacctc accttcacat 31441 ggagagtctt ggaagccatt tctaatagat gttgatggtg gaggtggggg aggtgcccca 31501 gcactgggcc tatcaggagg aaggggaggc ctgggtccac tcctgggact gtctactcca 31561 ctcctggatg gcaactgagg ggtagcaggc agggcccgag atgtgctgcc gtttctgctt 31621 actggaggag gtggtgggag ggggcctgga gcaaaaaaag acacttagtg cagaacctta 31681 catccacatt ccattaccRt ggtcaccatt ggtgtacagc tgatgaggac ttgctggaca 31741 catgcccttt aattagggtg attttctagg atatttggct gagaaatgag taaacacaca 31801 gaaacacaaa aattgcacat gtgtacacat gtatatgcaa aacaagtgca tactgatagc 31861 taaatgggtg ttttggcttt gaattagcac tcagattgga gatggcacag tgaaattgaa 31921 aacaggtgaa aatctgttta cacggacaac cgtatattta aaaaaacatt ttataatcct 31981 ttaaagagct attgaactaa ttactgtgac atgatgaaag aattttttta aaaagaataa 32041 gatagttatg aaattatttt aggtcttcag aagaacaaag Ktctttaaat gcatagtttt 32101 gttgttaatt acagaagcat gtttctgtga tgtatatgat ctgtttccag gcagaagtgg 32161 catcaggaaa ccaaatacca gtcatcctga gagcagtaag agtttcttct tggttcttcc 32221 tctttgggga ggcagataaa cacagggagt gacaaacagc taatcaacat ccatggctat 32281 aaatgctaat gtgaatcttg accctgagca agctggtacc ctatggaact tggtttccta 32341 gctgtaaaag agtgccagat ggtcacctgt ctcacagcac tgctgccagg aaaaactagt 32401 gaaaatgcaa ataaaaaata ctatgtaagt acttgaaacc attttttaaa aaaatgtagc 32461 agtatggtat aaccataagt ttttaagttt ctaagaaaaa ttcaaggaaa tttttttgat 32521 aatacaaaag aaaaccatct tgcttttcct atcctccaaa tgcaggggct atttgagtag 32581 taagtaaatt aaaaaaaaca aaaccaaaaa cttgagcatt ttccaatgta aatcaaaatg 32641 gccttagtaa ttatgcctgc tcttcagcag tgtgttccgc ttgtaagatg ctgacatttt 32701 atgtgaatac aatgtcttaa ggtgctataa ataaatatct tattagctat agattcagaa 32761 tccaattagg aaccttaaac tgaacaacct gcccactgca gatatccctg acagaaagtc 32821 ttggctccaa cattttacag aggtgggagg cactgcccag ccctgattgg tctctcaagg 32881 agtcttcagt gcctcacctg ggagtggtta tttattaccc tatctgcttg tcattgctgg 32941 agtcccaggc agcaagagtt gatttactga ggaaaagtgt ctcatttgct gtggttttaa 33001 cttcattggt gataccacca cacaactgtc actacatgca aactcaactt ccaatattat
33061 ggggccctgt actacgtaac ttcatctcat tttcttttta aagtaaatgg tcatgttcat
33121 gttcctaact ctccaacctt gtggcaccct gctccaaatc ctggcaggca caatagaaaa
33181 gaaaacagat ttctatttcc cactggcaga ataacagaaa tgatcattta ttgaatataa
33241 ctatatgcca ggaaataaga taaccactat acatgcttgt ctcatttaat tcttataaca
33301 actctgagag gtacagggat aggagacaag gcctcagagg ttttggaagc ttgaaaagct
33361 catcagaaga ctgagtggag gagccaggat ctgactccaa atctattaga ttccaaggcc
33421 cactccccat aacactgaag ccaaacaact cagaatacac agggcctttg atgaactctc
33481 atacgctcct tgtgggaatg taaattggta ggaaattcct ggaaggcaat ttggcagtac
33541 ctattgaaat ccatagttta ctatgcacac tcactgaccc agatattcca cttataggaa
33601 ttaatccaaa ggaaatacag agatgtgtac acatattttg ctacaaaaat atatcactgc
33661 attatctgca acaggaaaaa tctagagatg gcccatatga ccaagtgagg ggattggtta
33721 aataaatcaa ggtacatttg taggatttaa tattaggtag ctgttacaag tcaggctgta
33781 gaataatcat atcagcaaac attaatgaga tactgttaaa taaaaagcaa attagcaaac
33841 aatatatgta gtgggatacc aagtttgtaa aaacatgcat tttaaaaaga ctgaaaggac
33901 acattaaaag aatgttatca atgattattt ctggatagtg gtggtagaag gattaatttt
33961 aattttcttt atatttttca gtatttctat aataaacaag tatgacttac gtaatcaaaa
34021 gaaataataa atgttatatg tcaatgcctg tcatattttg gggaagattt aatctgctga
34081 ctcatccatt tggtagggcc atggcacaat ggtttcaagg tgtggttctc acattctgct
34141 gcacactata atcaccaggg agcttttaaa tatcctgatt cccagtctgc accccagacc
34201 aattatgcca gagactccgg gaagggaccc aggcattggt ggtttttaaa gctccgcaga
34261 tgattccagt acgtgagcaa gtttaaagaa tggtgattat gaggttcctg aggtcacagg
34321 gtcaaaggtc tcttatctct gcgtaaagga aaaaaatgcc ccatttccag acataataag
34381 gtctgtacga tgagattcaa ttttaaaagt gggtggttct actgagttca tccataacca
34441 ctataaaacg catcaagtga gcatattcta ctaaaaatgc ctattataat tcggagaggg
34501 caaactctag gcaatcctca catttccttt catactctga aagtttgtcc ctcagatcaa
34561 ggtttctcaa ctgtggatgg gggcattgga agggtctcag atgggcttca gcaggctctt
34621 caagccatgt gacagcaggc aaattttgag tttatgcctg agtatttttg taaagatagt
34681 ctataccttt atttgattct ccaagggatt tatgtaccag agattacaaa gagcaaaatg
34741 gactttttaa acattagtct ttaatgaata gggaaatggc ctcaaagcct ggcgaatgaa
34801 gagagaagta caggagaagt tcattagctc ttgaagaact tcccctcttg ttggaataac
34861 agagccctcc tgcgggaggt ggggacttat tttcccaatt aagaccgccg aaattctctc
34921 tagggaggca gggtagtgga ctggcaagta cacttcagag atggaagatg aaagttcttg
34981 cctcttcttt attaactagc tcgtgaccat ttaactttat tagctactca gtgtcctcat
35041 ctctaaaaca ccaacagaaa tattggtccc actttccYcc ggggtttaca cgaggtcacg
35101 atcacacgtg tcgtgtgcca cttaaaagca caaagcagtc tgagtttact tatgcctgct
35161 tttgttagac tatcttgact gacaggatta ttggtacatt tgggcaggct gggttttgga
35221 agcaactcac tccacgtctt gtcatacctg atcggcctgg cgggtccctc actggaggtg
35281 ggggtctctc actgggcggg ggaggaagag gacctgaacg tcctggcgaa ggtaacgggg
35341 gcgtggacga actgagggac agattccgct gtgggagtct tggggtttcg tcattgccgc
35401 tggaacttgg aggcagagga ggcggcccgg gcctgctggg aggtggcggc ggaggtgggg
35461 cctgtgagga ggccgaaggc cgcggagtgg aaggcactgg aggcttgttg ttctgaggag
35521 gaggaggggg aaccgcttcc ctgtggatgg agggcctgtt gcccactgga ggaggtggtg
35581 gagggggttt gtcatccaag gccctgctgg gggtaggcgg caggggaggc cggttggaga
35641 agggcgagga ggagctcaag ggggactgac gtattgagcc tcctcccaaa gcagtgccgc
35701 ggtttccagg gaaaggggga ggagtgggcc cggggctggg ctgcctgggg cctccgggca
35761 ctggtgggga cccccggttg tgcggacttg attgaatggg tcttggagta ctaggtactg
35821 gaggaggaat gctatcaggc tttgagccca cgtcgggcct tgggggcggc attcggttcc
35881 tctgaggctc tgggggacca cttctgtggc ctggagaagg cacaggaaac ctccctgggc
35941 cacttggggg tgaaaagggt ttcgcagatg tggatcttcc tcccggtggc aacaatggtg
36001 gtcggcttcc tccagaatct gaagaacagg aaaacaaaca tcagttagga aatcaggaac
36061 cctgaagaaa tcagagagct agagtctgtt cccagtgact ggaagtccct tcctcagagg
36121 gctataaaat acaggaaact attatttata taaattgggt tttgttggtc cttcttggga
36181 gcagaaaatc gaccaWagct ctatttacct gcgagtccca acttctacag cctatgagct
36241 ttcaaaagga ttctgcaaat atctcttagc attatgtata ggcaagagcc aggatgaagt
36301 gggcgagagt tctggtgaga tgcctattca ttatgagagg acaagaacaa gatggcattg
36361 gtagaatcat gattttcatt tttcctcatc accatctctg tctcccagcc cttgtacctc
36421 tcagttttga aactaagtca gctgtcttag gtgaaaaaat taattatccc aatgtaaatc
36481 tccaaatgtg agggcttatc tagtccctat gaagagaaat gccccaaaaa aagtggaaaa
36541 Mtgtaagggg aaattataag aaaagagtta tgactgcaat aagaaaaaac taagaaagga
36601 aaaagaacca tcagtaaagt ttaattgtaa gagttgacac cagtggatgg aattcatcta
36661 caaagaagca ggcaactaca caactttttt ttggtaccac gtcaacctct gcttcagtat
36721 tggcaggaca gaataatccc ataactgctc tggttcaaca agggagaaac taaaggggga
36781 accaaagaga tggaaaattt caaaccacca tcccagaatc tcttggaact caaggtaatt
36841 ctgaaaaaaa aaaaaaaaat ctacccattt atgagttaat aagtgtacca aataattttg 36901 agcacttgct atgcgcctgc cattaatcta gagactagag acagaggagt aaacagaata
36961 gaaaagattc tgcattcctg tagtttacat tcttgtgggg ggagataaac aataaaccag
37021 gaaataaata ctttcagata attatatgta ctaaaaagac actaaaatag gccgatgaga
37081 tcaagagtgc ttggagaggc cagggtacat ggagtggctg gggacagctc ttctgagaat
37141 gtgacatgtg agctgaggcc tgacaagaag gagtcagcca cggaaagatg aggaagacca
37201 gcactttggg cagggttggc cagcaggtgc agaggccctg aggtgggaaa gagcttcaag
37261 ttcaaaaacg ggcccatgtg cccggggcac agtgagaatg ggagagatcc atgggaagtg
37321 gagcctgagt ggccagcagg ggttagtcac aaggagccct gcaggacaga aggggttccg
37381 attttatcta aggcacagga agaagcattt ggacagatgt atacagtgga gtatcatgaa
37441 cttaagagag aactttcttc ttcttttttt tttttttttt gagacagtgc ctcctctgtt
37501 gcccaggctg gagtgcagtg gtgcaatcac ggctcattgc agcttcaact tcctgggctc
37561 aggcaatcct cccacctccg cctcctgggt agctgcgact acaggcaaga gccaccatgc
37621 ccactaactt tttgtttttt tttagtagag acaggatttt gccatgttgc ccaggctgtt
37681 cttgaatttt tgggcttcag ccatctgcct gccttgacct gtgaaagtgc tggaattata
37741 ggtgtgagcc accatgcctg gcccatttta ttattttatt tttctttgtc ttttgcctta
37801 atttcttcac ctgttgttaa agtactaaat gtatacattt atcagctgcc ttaaatcctt
37861 ttggtgagtt ttaaataaat ttaaattcaa atttaaatgg tggtctggca agatagaacc
37921 tctcatgtga ctgagtttct ctctagattt ggaccattca gtgataaaat agtaggctaa
37981 ccctgaggat tcagtgattc catattcatg taaatgtgag agtttcattc tttcccaggg
38041 gacatcttat aaaaggtcta aaaatgaaaa ttattataac atgatcaaca ttacaaaagc
38101 agttttatgg taaaatttct tgagtttctg tagtagctgg gagagagcct catgccctct
38161 gcaaagtttt ttatctaggc attcatgagc aagttcagtt tttttctacc atcaggttca
38221 tagacaatcc tgaaggactc atgtccatgg ctccctgcag agactcctga gaaccactgg
38281 cactgaaata ccaaatatct gtcatgcaaa acactttttc agatttagtg agatttgtaa
38341 tcatattcca caagaYgtgc tccatcgtgt ttgaaaagcg gctcacaagt atttactcta
38401 ctagacagct gggctacctc acaaagaaag ctgaatctgt caggtcacca ggcagatttc
38461 cagggccagc aagttctatt tgctcctccc ttttcttccc actccagcta accctttaga
38521 aaagtaaaaa aaaaaaaatg tacaggttac ccccaaagac actgggtgaa aatttcatag
38581 ttctgtgtag ctgtctgatc ctggttaata ataataataa agcctaaatt gagtctctta
38641 taaaacagtg gtaatattta aaacaatgta caatatttta ataagggcga agagccttag
38701 aggctatgac cagcctccaa actgccaaac tctgccttgt cttcagtcac tcagagacag
38761 ggaaactctc cttaccatta tccctgttgg ccgtggatct cagcttcggc attccagcct
38821 ggaacaatcc tcccagacct ggaggtccgc cccctccaaa acttccaccg cctccgccac
38881 cacctcctcc gccaaatccg ccgcctccac caaagccacc accaccgcct ccagcaccag
38941 ctcctttagg ttctgtagaa gaagagacac ccgacagact atgccccctg gtctggccca
39001 ggtaaaccat aaaacaacag tacaacaggg agctggccgg ctctcggcct ccagtggaca
39061 actgggattt cttcattaaa atgcaggatt ttaagagttc cctcagctca gtcagaactg
39121 cccgctccag gcagtcccaa gcccagtggt ggaagaaacg aaaataaagg atgatttgtc
39181 cccacactcc ccacttgact ggctgccaca tgggtcagta tctgtttgtt ccgtatccta
39241 agatttggca aatagaagga tcttcaggct gggtgcagtg gctcacacat gtaatctcag
39301 cactttggga ggctgaggtg ggaggatcgc ttgagccagg gaggtcaaga ctgcagggag
39361 ccaagactgt gccactgcac tccagcctgg gtgacagtga gaccctgtct cagtaaaaag
39421 gatcttcaaa gaaagagggt cgcaagggag gaggagatgc cataaaaggc gagaagaaag
39481 gaaagagtta aaaagaaaag aaaataaaat atctcataat ttcacaaata tacaaatatc
39541 caggctaggc acagtggctc acacctataa taccagcact ttgggaggct gagactggag
39601 gatagcttag gccccagaag tttgagacca ccctgggcaa caaagtgaga cctcgtctct
39661 acgaaaataa acaacaacaa caaaatgtag ccaggcatgg tggtgcacac ctgtagtccc
39721 agctacttaa gaggctgagt gagaggatca cttgaaccca ctgaggctgc agtgagctat
39781 gattgcacca ctgcactcca gcaaaaaaaa aaaaaaaaaa acactaagca aatatccaca
39841 attgagttat actttttccc atcagtattt ttcattttat gtgttttttc ttaaaattaa
39901 gaacaaattc actaagcagt attaagcctg cttttttcat ttaacacttt gttagcactt
39961 cttgtgtcat actctttgaa aacatgagtt taaaggattc tattgtattg tagaacatga
40021 atgtattaca ttaaaattta tttaactact catttgatgg ccctttagat tgctattaat
40081 tttttaatat catgaagccc aatagtaggc tttagtaatt taaacattct ttgcaatttg
40141 agagggtata aagatcttgt tttattttga atttatctgc aaaaaattgt gaaagatttt
40201 gatgggaggc aaacaaacaa acaaacaaaa agattactga gtattctgtc tagtcttctg
40261 ggttactttc cattgtcttt gagccacagt atcttatcac tctgaaaggc atagaaaact
40321 gatactaatg caatggtatt tgtccaaaga agtgcaaatt agttgtgttt aagccatgct
40381 tataccctct ttaaaaaaat tatctcttaa tttatgtatg tatgcatgtt tgtatttatg
40441 agcttaaaca ttatttaaag tcctcttccc aaaaaactat gttgagtttt tgataaatag
40501 tatatgaaat ctacaaatta atctgggaga actgatactt ttatgatatt tagactttcc
40561 atttggagat gtggtatatt ttcccattta tttatgtctt ctggattttt tggcaaagtt
40621 ttttagtttt tatgatatac attacacatg ctttttgtta gggttacttc aaatgtattt
40681 ttgtttgctg aaattgtgaa agggatgttt ttcctgttat attttgtaat tggttatttt
40741 tggcaccagg aaattgtatt taatatctaa taagccactt tgctatgttt tctaaataaa 40801 atttactaaa aatgtattat cttgcatttt ctagtatgca catggtcttc aaataatgac
40861 agtttaaagc ctcctcttct ctaagagttg tatgtcttat ttctgtttta tataagtaat
40921 tactttgatg ggtaaatttc cataacaatg taaattatta acgtttctaa aggcaatcat
40981 gttctgatat taatgagaat ccctctgata tttcaaagtt aatatgaatt attggtttga
41041 aataggtttt ttccctttct aaatattcag tctgtggatc cttctatttt aggtttacaa
41101 gaatttatta tagcatgaaa ttttatcaaa tgcctattca agatctactg aggctttttg
41161 atggtctttt ttatttgata tgatggatag actttctaac attaaaaatg ggataggcca
41221 ggtgcaacgg ctcaσacctg taatcccaac actttgggag gccaaggcgg gtggattgct
41281 tgagctcagg agttcaggac cagtctgagc aatatggtga gattcccatc tctacaaaaa
41341 atgagccaaa tgtggtggtg catgcctgta gtcccagcta gttgggaggc tgaggtggga
41401 ggatcccttg agcttgggag gtcaaggatg cagtgagctg tgttcatacc attactccag
41461 cctgggtgac aagacaagac cctgtctcca aaaaaaaaaa agggggataa accctggtgt
41521 tggtgaatta ttcttgtaac atctgattga tttagatttg ttttttggta ttttagtgtt
41581 ctcttatcta tgatgataag tggtccataa tagggtttct taattataaa cattttggga
41641 cagataattc ttttttgtgg gtggctgtcc tgtcctgttc tttacagaat gtttacagca
41701 tccctggcct ctacccacta gatgtcagta gcagccctcc ctgtccccca aagtagtgac
41761 taaaaatgtc ttcagacatt gccacatatc ccctggaatg caaaaatcac cctcagttga
41821 aaaccactaa tgtacagctt tcttttttta tgtgctgcct ttgtcaagtt ttgacattag
41881 gatcatgcσa atttcattac aattattaga cagccttcca tctcttaata tattggggaa
41941 tgacttatac agcatttgaa ttagctgttt cttaaaattt gaaagaattt gctaataaaa
42001 taatctggct ccaaaacttt ttggagagaa agtaatttaa taaagttttt atcttttccc
42061 ttgctcattg aggtttcctg aataaatata tgcttttctt agaaaagtac tttctttaat
42121 atcttaaaac attttagcag ataactttat tacactactt taattttaga aaatatgctt
42181 tgaatctctt attttatctg ctttctgagt tccactttta ttcattttta tttccatttt
42241 ctggattagg tttatcataa atttgtgtta gttctgtatc ttttctagat gtggagcttt
42301 ctgagatgct tatggtagct ctgctgtgga agaaataatc tgataataac tgacaagaat
42361 tacttcacct aacaggataa atcatataag actaacaatt tctagaagtg tatgcaaaat
42421 tgtttccata taaaatttaa aaattttgct attaacatcg cccttgtcat tcaaacacta
42481 ttcattgatg aatgacacat tttggaatac tgcacttcac aggacacgtt tacatggtac
42541 tgaaacttta gagggactcc tgcactatca gacatcaccc attactgttc ttttttttgt
42601 ttttttgaga tggagtttca cgcttgttgc ccaggctgga gtacaatggc acgatcttgg
42661 ctcactgcaa cctctgcctc ctgggttcaa gcgattctcc tgcctcagcc ttccaaatag
42721 ctgggattac aggcatgcgc caccacaccc ggctaatttt gtatttttaa tagagatggg
42781 gtttctccat gcctcaggtg atcccagcct caggtgatcg acttgcctca gcctcccaaa
42841 gtgctgggat tacaggtgtg agccactgtg cctggcccat tagtgttctt aacctgcaac
42901 atctgtccat ctttcagaaa gagaagctaa agctgaggat taagctttca gattattttt
42961 tcagtaatta aactgtagga cagggctgag ttatcacaca taaccatggt caacattttg
43021 acatacagcc cagggaagtt tcacatgcaa acagatacaa aactgtggat aaacactgct
43081 gcttgcaaag agcttgtgac agcagtatag gtgtccagtt gagtgtgtgg acaagggcct
43141 gcactggact gtatcttcct tccatcaagg aaagcacatt attaaacatc atggaagaga
43201 gaaggactaa cactatttcc attaaataag agaagtggac attgaagaat acaattcttc
43261 aaggtttcca ctagtggatt caggaatagg tctagactgt ccagcctcct tcaacagagc
43321 cctaggctcc ctcttgcagt gaggagaacc acaggcctct gtcctagagg tcagctcctc
43381 tggcctcata ccagggacca tgattcagat ggctattgga gggcttggag ggctgaggga
43441 ttagagggaa tatattataa ccacattcgt tttgtgggca ttttgactta caagtcagac
43501 tgtgtcaaga gttaaatacc ttagttcctt tttttttttt gagacagagt cttgctctgt
43561 tgcccaggct ggagtgcagt ggcacaatct cagctcaccg taacttccac ctccttggtt
43621 caagtgattc ttgtgcctca gcctcccgag tagctgggac tacaggcatg tgccaccaca
43681 cctggctaat ttttgtattt ttagtagaga tggggtttta caatgttgtc aaggctggtc
43741 ttgaactcct ggcctcaagt gatccacccg cctcagcctc taaaagtgct ggaattacag
43801 gtgcgagcca ctgcgcccgg ccatagttcc tttttgaaag cagtgcattc tcactcgcag
43861 cactttgccc ggtaacagaa caacattcaa aggccttatc taggtctttc acttttcctt
43921 tttcctccca aaccagtagt ccacctaact ctgatccttc ttcttccttc tctactcatt
43981 aggtatttct cccagaaagt tccctgaagc acttctaatc ctttactttg caaagattct
44041 gcctcattat tcacttgttg acaaagatcc atctggtgat tttggaaggt cagtctattt
44101 cctgttccgt ccaaatggga tctgtagtct aggatgaatc ttggggacat ctggcaggca
44161 aaggaagggt ctaggaatgt gaggagacag gcttaagatc tacttattaa ttgccagtag
44221 aattctagtc atggattatt ttttgtcctg ttgtaaatgt taataagtag ctttgttcca
44281 gaaagtacct cagacttagg tgggttgata actgaagttg tgacctcatt ttctttctct
44341 ctaagctcct aataattgta tcttacactt gaattacact ttccagacaa caaaacattt
44401 tacaggcatt atctcatttg aagctcatga caaacttgtg aggtcaatag aacatgtatt
44461 atcatctcca ttttaaaatg aagaaaacaa ggcttggaga tggtacagga tggatgtgcc
44521 aggtcttgaa cccacagctt ttgattccaa ggctagggct ctttccatat tttatgctgc
44581 ctcctcatct gtggtgccag gagcaatggg ttaatctcca gaaagtgttg tgaataatgc
44641 agagaattgc tgctgtgtat gtcttggaca aagaattatt atactggctt cttgcagcat 44701 tagaggggaa cccaagccaa agctgcggcc tacagggagt gatacagtcc cttattttgc
44761 tagctttgca gctgttgtta accaaaaaat aaaataaaat aaaaattgag tggtgagggt
44821 agggttgatt attaggccat aaactgttcc tctccatggt agatagcctt tttttactta
44881 ctgtccagta ttggtgcact tctgtcattg gtgaccgtct tctttagttt cttccctttg
44941 ctgatatcag aaaggagagc atttctccca gcctgctctg tcttattcaa ggtaggcttc
45001 tctgtattgg cctgaaaggg agccatacaa acaagtagtc atctcttggg ttaaaatcat
45061 gcattgtaac actcggctgg gaaaggttgg gtacgggaag cttgttgtta aggttcttgg
45121 tgataggttg taaattctcg acaagtttta gaccccatat ctttcttttt aagatccaga
45181 cgtttggaag cagatgcagc aataaattat gttcattttt aagggaggaa gagtcagtcc
45241 ttgattaaag tctctgaaaa ttcagaccac aatctgactg aaactaacag ggccaggtta
45301 gggtgagatg actagacacg agaaaagaat tttaagtctg ggaggattct gcaggacatt
45361 accagacgtc attcactaga gggtaccctg aagaataact tccttttccc atcttttaga
45421 actaccccag tgcaagggaa aaactgtctc tagcaaaaag agtcagctgt atgtttttta
45481 aacccactaa agttctagaa aataattccc tctgtgtata ttgccaaaga tgcttttttt
45541 ctctttttaa gtcagattta ttaaggtgta atttacaYat agtgaaatca ccctttttag
45601 ttacagctct atgagttttg acaaacatat acagttgtga aaccaccgtc acaatcaaga
45661 tatagaatat tttcattact tcaaaagttc cctcatgtcc tgttggcatg aggtgtttct
45721 gatgtttaat tctgatgaaa gcttagctca tggaaattgt ggaatggaca aaaatgctgc
45781 tttaacatgt ctgattattt tcttatattt ccagaattcc taggaaagat ccctacctac
45841 tatgaaattg ggatcttgtt ccttcaggga gttggggaca ctaagagacc agcaaatgga
45901 cttagatgta ggcacctgcc tgtgtgcctg tgtctatcac acttggaaac tggctaggtc
45961 ttgtctgtct cagggagagt ctggctgccc caaacccaca ggtcctttct aggctggccc
46021 cagcccttct gacagggata tgatttcaga tttgccagtt agggccacag gaggaaaagc
46081 tggggaaatg tatggctcaa taccttaccc agcctttaaa aaacaatttt tttttagaga
46141 cagagtctca ttatgttgcc taggctggag tgctgtggct attcacaggt gtgatcatca
46201 tgcaatacag cctcgaactc ttgggctcaa gtgatcctcc tgcctcagcc tcctgagtag
46261 ttgggattac aggcacgagc tactgctcct ggcctaactc agccttttat tagcagagtt
46321 agaggcaaag gaagaactca gaaaaaccct gaagtaggct aaccagaatt gcagtggtaa
46381 agttggaagc atcttgaaat aactaaatga tgaagtatta cttgcttatg ataataatag
46441 ttaacatata ctctgtgcca ggcactgttt tcagcacctt atgtgtatta cttcatttag
46501 cccttatcaa ccctgtgagt tattatttcc attttacaga caaggaaact gaggtatagg
46561 gagtttaaat catttgcccc aggcacctag ttagttgagg aggagctggg attcaaaccc
46621 tggcagtcaa gagccttccc tacaagctga tagaaggata aatgtgggct ctaaaatgcc
46681 cctccccatc cagccccaac acaccgctga agcatgcttg ttaaaagttt ctctgctgtc
46741 cttccagaaa tgctctctgc atacacagtt tgcttttgct aatgggattc tcctctattg
46801 ttctgcaact tgtttgtttt caacttaaca tactttggat gtcctggaaa agagctctta
46861 aσattacctg ctgtcttcat tttaaggatg aaaaaactct gaggcctaga gaggttaagt
46921 gatgtgtcac actggatctc ttaacagttt tgggtcagca accttcagta gcctcctgtt
46981 ctgcctcaaa atttattttg acagctgacc tccctgggtg ctaacttctc tcatgttcag
47041 ggcccttaat tatgttgttt cacaagggca gtgttctatg atggccacca acccaccttt
47101 tccctttctt catctctata ttctatttat ccaaaatctt gctttgaatt aggtaacaac
47161 ggatagaaat gagttgataa gataagcaag gtttcccaaa cttcaagcat tctggtataa
47221 gattcatgat ttttgtcatc ttctcatacc acctgtgtta tttatttaat attttttatt
47281 aagtcagttc actatagccc acacttttgg ggaaacatgg ataaatgaat cctgctatgt
47341 aagccagatt ggaggttctc aaacttaccc atgtgaagga ccaacttttt ttttgttttt
47401 tgtttttttg cgacagagtc ttgctctatc acccaggctg gagtgcagta gtgcaatcac
47461 agctcactgc agccttgacc tcctgggctc aaacaatcct cccatctctg cctccagagt
47521 agctgggact ataagcacgc accgccatgt ctggctggct aatttttaac attttttttg
47581 tagatatggg ggtctcgcca tgttgcccag gctggtctcg aactcctggg ctcaagttat
47641 ccttccaaag tgcacgcctg gccaaggacc agtcttttga aaaatatttt catcaggaac
47701 tgacgctttt gtaaaataac aatgaattat tagaaaaatg aattagtttt ttaaaaaaga
47761 cacacaacat ccaatcttag aaacagaaaa ctactgtcaa attgctagaa atgcttctaa
47821 atgcttactt tcaacttttg tcctcatcac tttggggact cttaaaaagc agttggaagg
47881 ccacactctg agtaacaata agctaattaa taggcagttc ttctcactag gtttcaacct
47941 cagatgagtt atataaatgt gtctcatgga aacctggggc aagaaacttt ctctccaagc
48001 ctcagtttcc ccatgtgaaa atggtgaaaa tgaaggaacc atcagtgtga ggctcctcct
48061 cagtgaaggc ttcacaagct ggagagggct ttgtaacaga gcgtatcttg gggcctttcc
48121 atatgaccaa gtggagagtt gccaaattcc tgaagagggc acactaactt ccccaaagag
48181 gtctatcaaa ggagcaggat gagccgggca cagtggctca cgcctgtaat cccagcactt
48241 tgggaggccg aggtgggtgg atcaactgag gttaggagtt caagacaagc ctggccaaca
48301 tggtgaaacc ccgtccatac taaaaataca aaaattagct gggcatggtg gtgcttgcct
48361 ttagtcccag ctacttggga ggctgaggca ggagaatcac ttgaacggga ggtggaagtt
48421 gcggtgagct gagatcgtgc cattgcactc cagcctgggt gacagagcga gactcaaaaa
48481 aaaaaaaaag accaggatga atccactgaa gaaattcttt caggaaataa acatctaaat
48541 gcctaaatgc aagtatagat ttaaaggagg atgtgaatgt gtatggcaga ggtggtggag 48601 ggagatattt gtcaaaaaca gattgggaag aagaggggaa aaggcagaaa aaaagaaagg
48661 agtgagaccg gaagacactt taatggaatg cactgcaggc agagacctgg gtttctagac
48721 cgtccagccc agaagttaaa ggccagacat tgagttcatc tgaatgaaaa cagtgcacac
48781 tggtctcaga actgatcctg caaaccctat cttgggccag cacatgtccc tgcgcagatg
48841 cggcagaaaa cacctcatca gccacattcc acccttgtac tatccatcac acgagacctt
48901 aaacaaacaa aacccttcgt gttgtttgta tttgctgggt ttcaggattt ggcttaccct
48961 gggcactggg aaagcctgtt gtatcacatg tgagccagaa tgcaaacaca tttaatacaa
49021 acacatgcac gccaggtttt ggcttcattt ggcttgcttt atgcatagaa agtgtttggg
49081 gaggagacac tcaccagtgc aaacgtcggg ggcggcgggg gtgctggagg gggagggaca
49141 ggcatcttgg gcagttatgc gttcaacagt cttgctgata aatctggaaa aacaagaatg
49201 cgatcatgta ttagatgtaa tcttagtaat actgtcctaa tctgtcttca ctttcccacc
49261 aaagtgacag ctccacctag ctcaactctt agaagagatg ggcttacctt tacacctcac
49321 tgctaaaaca ttactgttct ggaaggatcc cggcagaggg gcttctgacc cgaggtgctt
49381 ggagagaatg gaggccacat ccagtgcctt actcggctcc attcccccac ccactacagt
49441 aggccatgac cgacccaggt gggσccagtt aagcaggaag gtctcacaca actgctagga
49501 tgtatcctgg ccaagtttca ctgaaaacaa attcacttca agtggcttct cctcttcgct
49561 aatttccatg acaatccttt catgctctcc caccccctct ggctttctcc tcccattctt
49621 cctgacattc gccWagtctg tgtgtgcact gcaggaatat gaaaatgaat ctacttctag
49681 tcccgccctc aaagttccta gtcctccagg gagagggcat ggagaatgtc aggtggaaag
49741 cagggagcag cagctgaggc ggggtggacg tgtKgggggt caaccttatg tttggagcac
49801 tcaaagacca gccatcccta tctctgtgct ccttagcatt tcctcagagg atctaagcga
49861 aaacagagcg ggcatgagaa gtcagaccta ggactcccag gctgtttacc agaaatgcat
49921 ttcatttaga agagcctgtc ttagctttgt ttgggtaaaa aattatatat aaataaaata
49981 aaaaagaaga gcctttctgc agagtgtgct tgctctgaaa acaaagggaa gaccagattc
50041 cgtagctggg taggaaagtt tagggacccc aggtgggtga gggggcaggg cggagagggc
50101 agcctggcaa acaccagggc caggagagac gatggccagg aagtgcctgg tgagttacac
50161 cagccaggag ccctctcccc atttcctcta atccttgcag tcctgttcct tcgcctcact
50221 agaacccctg ctccctctgc cctgtctagg acaacgcctc acccactgtt ctcatcccta
50281 agcaatgcca gcttctccca ccccatcctt gctacacaaa ctgtggtcct ggataggcag
50341 cgtgggcacc acccagaagc tgttagaaat gtcaactccc agtccctttt gcccccagct
50401 gaattcgttt cagcatttta acaagatccc tgggtgattc atacgcacta aagccctatg
50461 tagagatcga gccttaagcc agcgggcagt ctgggtcact ggccacctga ataacattat
50521 ttctacagga catgtgtccc aaattttaaa ctgcagaatt atatttcttt aaaaaatttt
50581 tttaaatttt tttttggaga tgaggtcttg ctctgtcaca caggctggaa tgcagtggca
50641 taatcatagc ttactgttgc ctcaaattcc tgggcctaag caatcctcct gcctcactcc
50701 tgagtagctt agctaggact gcaggcatat gccaccacgc ctggctaatt tatttttatc
50761 ttttattttt gttgtgatgg gtcttgctat gttgcccagg ctagttttga actcctggcc
50821 tcatgcgatc ctcctgcctt agcctcccat agtgctggga ttacaggtgt gagccactgt
50881 gtcaggcttt ttaaactccc aatagtccct taattgcaaa aaacaatttc ttagaattta
50941 aaatattcat ttagttcaac cactacaagt taatgtggaa aactgaaacc taaacaaata
51001 ctttctattg agataatgct aaatggcttg ctttctgtga acagaaatgg actggagaag
51061 ctaaaaaaga cactgctgga cttgtcacag ccgccgggaa acaagaatta agacagttYg
51121 gaagagtccc attcaaagtg ggcggtctag aaaatgaaaa ttttaaattc cacagcagca
51181 Rcagcagctc tcatgtatgg agaatctgct ggatccaggg ctctatcctt gcgtggtctc
51241 tgactcctaa gacagcggaa gccagcatcg ctgtgctcat ttgatagact cagagaaatt
51301 aaatcactcc ctaaaacacc ctgaagcaat tcattcagtc atgtcctttt gcttcctgct
51361 cttctgctgg ataacactgc ctcactcact cactgccctt ttaatggtct gataaacact
51421 ttcaggcagg cgaattagtg ccacagctca cctgttaact aggctggaat ctgttttcag
51481 taagagactg tctcaggcaa ggattctttt aaagtctgtt tcttaaattg ctctttctgg
51541 catgacatca attagtcacc catagggcca catgggcatt gtgagcagga ctgggtgcct
51601 gtgttagggg gtcctccatc aaggggcatc tccagcggca cattcagagg cYttggagtc
51661 agacgtctcc taggaccagc aggaacgaaa gggatctgat tcaggcctga ctactgcgaa
51721 agatgctgga gccaaatcaa tggtatgatc agagttggga aaggcttacc aaggaagggg
51781 gatagcctgg tctgcccggt gggcccaaga gatgggctgt gggaacagtg catccacgtg
51841 cttggttgat gaaaaatccc tcaagactat tttgtctgac tccacgttca ccgattaact
51901 ttctgtcatt ctgtgatcct aatatctagg aaagggtgga tattctggtc aactaacagg
51961 aacctcttat gggtatggtt gtcatgagtt cggctctcgt aacagagatc aaattgaact
52021 tctgtcctgc acagcttagg gggcagactg tggaatgggg accctttcag gggctgccac
52081 cctgaaaggc ctccttaatt attttacaat tctctgttgc tgctgtttta gtactgtctg
52141 tgcactaact gacttgtata ttaacttctg gatgacagct ccagggaggg cgtgttaact
52201 tcatggtcca gagggctagt gtgggagaaa tggcaacagt catggctggg gccagagcca
52261 aggccagatt gcagaaatta gcaggcaaaa acaaggttca gggagcaaga tgctattaaa
52321 gggtctgagg tattgaaaga agtgctgcct ttccttcctg gccacttcag atggacagtg
52381 gggagagggt ctacgggtga gggctctcac tttttagagg gtgatgcaga actaagtgct
52441 ctttcctctc ttcctctgcg aacttgtttg catggcttgc tttccctggc cccatctctc 52501 actcccctcc agattaactg tccctttcca atctcaatgg taacacagat gagggaggct
52561 gccatgtcct ctctcctccc ttctagctga acaactgctg ggcacggtct ggacttctcc
52621 aggctggggc ctcaagggaa gtgtgtgaga aaccccagac tccaatactg ccacctcact
52681 cagcccctgg atcaaagacc aagctcgtgt gccccaacac tgggcccacc ggccacacca
52741 ggcccacttc ttggctgtct ttccaccagc ctatggactc catggggtct tgccaatacc
52801 tggcacaaag tagggttctt actaaatata tatgcagtga aagaactgtg tatcacacaa
52861 acaagccgag tgcttgccac ttgaagggct cccagcatca ccccaccgca ctgtgagatc
52921 tgggcaaaag aatcagccct atttcagagg ggcttgctag tgttgcagac tggaacttac
52981 tttcctggca gcctccaact tccccagaga agtagagccc caaggccctg ggagaggagg
53041 gcttccctcc tctcatggac ttgacagccc acatcagagc cacagccaga tcttactgaa
53101 ggccttggcc ctagagcacg gatcctaaca gaccaggcat tcctgcctgg atcctcacac
53161 ccagagtctg tggatagaat tcaagggttc atgaacttgt atgaaaaaaa agtacatatt
53221 atttctacta agcactaact gaaatgtagc atttcctttg attatgaatg caggccacaa
53281 accataatat ctgatattct ttcacccata gttttcacgt gatatttcac atcatattac
53341 aactacacac caacaatttt caacatgctg gcaacgttta gatccattgc tagatcttgt
53401 tgtttaaacc attaataaag aagtacatat tttaataaat tagtttcctt tgtaattctc
53461 tgtattttat tttatgcatt taaacgtaga cacaaaaggg tccctttggg actgggagtg
53521 gtgacttatg cctataatcc caacactttg ggtggtcaag gtgggaggac tgcttgagcc
53581 caggagttta agactagctt gggctacaaa gtgagccctt tatctctaaa aataaaataa
53641 aataaaataa aaacaaatta aaattaaatt ttttaaaaaa aggagtcctt tgggctttac
53701 cagtgggttt atagaatgaa aaagggagaa catgagacct tggtcaggca aatttggttc
53761 tgaatccttg ctctgccacc tggcagattc agatgggaat ttgtttttcc catctgttaa
53821 atgggaagtt gctgagcaga ttaaatgaaa tggtgtgtgc aaggctttca gcatggcctg
53881 ggggagcaaa gctgtcagtg gacagggctt agctctgtcc ttcagagggt gaggatgggt
53941 cctgctggta caagctgctg agtgcctggc agaggaggga tggacctgga ggctagtctg
54001 aggggccaca gctttgctca gtggctgtgg gtggatctgc ctgggtggga atgaggctga
54061 ctgatgactg ggcctcccag catttggttc ttcccttgga gatgggagca tggcaggaaa
54121 ggcagctgat tcgggtgcag gagagacgca agaagggaag ggactcagca gcagtttccc
54181 agtgtggtca gtcatctcct gcatcagaat ctgctgtgcc tgtgtccggc ttcccagact
54241 agttgggctc tcagtagtgt cggatcacat gcctacccac ttgctgggcc ttgccctcct
54301 accccacccc aacccaagca atgaactttt aagaagtcac acttttcaga attaatttct
54361 ttttaagaat aatttcaatg ttaagtaact ttcatgatag aaaagccaga ctttctaaaa
54421 tctttacttg gtgtgttgac ttctacaaac acaaagaaaa ctcaagSgac agaaaaggct
54481 tttgttttca catacagtat tacggtctga actatgtccc ctgcaaaagt gatatgctga
54541 attcctgacc ctcaggacct cagaaggcaa ctgtatttgg agatagggtc tttaaagagg
54601 tgattaagct aaaatgaggc cattgggtga gatcttaatc caatttgact ggtgtcctca
54661 tacaaagagg aagagacatc aggcatgtgc tcacacagag gaaagtcttc aagtgaagac
54721 gcagtgagaa ggtggcaaac caaggaaaga ggcttcagaa cacaccaaac ctgcccacat
54781 cttgatcttg gacttccagc ttccagagct gggagaaaac aaatttctgt tatttgatct
54841 acccaggctg tggtatttta ttatggcagt cctagcaaat taatacacat ggttttaaca
54901 acatacgttt gtctattatc cattgtggaa acaataagat aatggccttt gaataaacta
54961 tccatcaact gatttctcag caagatattt ctggattgtc atacgttaaa aaatttaaaa
55021 atcagccaga accctagagt atgtaagtga ctgccaaagg tttatttaat aagtgaatga
55081 atcattcaaa aataatgaaa ttttaggtga aaatagctga agtaagggga gggatctagc
55141 aataaccctt tcgtaaggaa ctggctttat gggttgagag aacagagtga aataatttgc
55201 ataaatgact ttaaaaattt aattactgtt tcttctttgt tgcttacaca cacacacaca
55261 cacacacaca cacacaccac cccaacattt agaaattctg gacttcctag ttcattctgt
55321 gaatgaaatg gctggcatcg tttgtcttac tagaatgcta ttaggtcaac atcatggttt
55381 aacacttaca tttagacaac attcactgat cccagatcaa ctagggcatc ttgcagcctc
55441 gactcacttg ttaaacatgc aatgttcgct acaacgagca ctgtgagaga aagagaactg
55501 ctcagcccac tcccaacagt acaggggaca cattctcctc aatggcatgg ccaactagag
55561 gtcaaccata gctcacagtt cagtccagac gtgccccagg aaactcaggg tttcttcttc
55621 aatgtgctca tctaggaaag cagactcatc cctgaatgta aaatgattgc cttccttggg
55681 atcaagaaag tggggtagtt atttaaataa gctgtttctt agtttcatag ccaacttaca
55741 attaattcta gattgcactg cYtagggccc acactacaga atgacatgag gtggggagtg
55801 attcctaata gtccccagtg aacacagttg acaatcctcc aaaggccggt ctctaatccc
55861 aagtgggcag gggttctatt agagaagata agaagcagct ttatccaatt acatttatca
55921 ttaatttgga ctattcaaaa atataaagca ttttgctcta taaatgttgc taaaagtaac
55981 ccttaaatac tatcatacYt aaaatgaatg gtggaatatt aaacttcttt tccccaaaaa
56041 gattgaatca atagaggaat attttatttg ctgggggtgg gggagggtat cagaaataat
56101 ataactggat agattcaaaa atccaactgc tctcttgccc tcattatttt ctatttttat
56161 ttacatttat ttattgattt tttttttttt tttttgagac agagtctggc tctgttgccc
56221 aggctggagt gcagtggtac gatcttggct cactgcaacc tccacctcct gggttcaaac
56281 aattctcctg cctcagcctc ccgagtagct gggattacag gcgtgtgcca tcacacttgg
56341 ctaatttttg tattcttggt agagatgggg tttcaccatg ttggccaggc tggtcttgaa 56401 ctcctgacct cacgtgatcc acccgcatca gcctcccaag atgctatgat aataggcatg
56461 agccaccatg cctgaactca tttatatttt actttatata taatgctctt aactcatttt
56521 catctatgta tttcttgagt gcttttggca tcttcaggtt agttttttgt ttgttgttgt
56581 tttcttcaag atttcttttt tttcttttat attgtagaga atacaaaaat atacaaagat
56641 gaaaaaaaaa agcactgaag ttgtatttaa ccactaaagg aagcactgaa taataattaa
56701 tttttatatg aaaaagggtt gggggtaata accagaggta actctttgtt attttgatac
56761 atgtccttcc agcttataag tacatgtaca tctctctctc tctccctctc tctctctgtg
56821 tcacacatac acatatacac acaattgttt gacaaaaaaa tattaacaga acaaaattta
56881 taatacatgt aacacaaaag tgttttcctg agaaaaggtt tttaaattca tattgagtta
56941 ttacaaccat aaaaaataac tgcaagggca ttcattacaa agacagtgaa tccactccaa
57001 gtcaccctgc aaaaataaaa tcatcgagca aactcaaatt gctgctaaga cggtgaattt
57061 taaaaagcat gtcgttttgg gattcctact caattattct tgattctatt ctttagatac
57121 tcctccatga tgcaaactta gctggatgta tttaagatct gaaaaccatt agaactaatt
57181 aagatgaatt tggctttgtt cttcaacttc ctgtaaaaaa tgctcaacag gaaaattgat
57241 gctcgcagta aaccacagtc atcctgtttc tttaacacaa tcttttcaca gctgcagttg
57301 cctggagttt ctattttatg acgcgagtca ctgcaacagc tctaccatcc cttcccccca
57361 gcatgtggtc tggccatttt agaaactttc aatacctttg cagaaaggtt cgtttctatt
57421 attgctactc ttcctctctc caagctgaag gtccttgctc agagcaataa gccatggata
57481 caagagggga aacagaaaag gcagctggac tccagaggaa gcaaaaggca gagaagagga
57541 aaacagcttt attagcaaat cagcagcctc acccagttgg ttcttatgca ttgttagtct
57601 ccatttgagc tgaatgtgga gcacacgctt gccatacaca gaatccctca tttctcaaaa
57661 tgtactgctc ttttctcagt caatcatcat tgaaaaacaa tacttcagca acgtctgatt
57721 aggttgtctt cttaatggta aatgtcaatt taagtctgct gaacctagaa atgcttcttt
57781 tatagttctt ttagataagg aggtgattta ttttggcggg gagtaggaaa ggtgtttttc
57841 aaagaagaca ttttgaagca tctcKaacat cactaagact ggctaggagc ttggacacaa
57901 ttttactgca agagtactgc tagggaaata aaggttgcta tgaagtaaaa ttatttttta
57961 atccactatt gtgcacattt aattttaaaa ttaatacaaa ttcacagaca tcgaagaccc
58021 ttttaatagt gagaaaatga aggtgagctg aatgacacgc ctacctgtca ttatttaact
58081 gaaggaaagg gaaaggaaac atttttattt tatccatata attaaagagt agcaggtttt
58141 ctcccatact tcccatctct ttaaggggtt caaatctcca agctaaaatc tgcctaaatc
58201 gctatcacca catttagttc taccagagga ttaagatgtg ccactgtttc tctctctctc
58261 tttctctctc tctctctctc acacacacat acacacacag catatatgtc agcacacttg
58321 atatatactg tattcatttt atcattgaaa gtacagcttt atgatataag cagaagtgtc
58381 accaagttta cctctgaaga agtgaaaaga cttaaaaagg aaaatatctt acttgagatt
58441 gttagtttta aagatattta ctgttgctgt gacatttaaa gcaaaacatt tgtaatctca
58501 gattcccaag gccggaaaag cacctcaaga aatcatactg gctgggtgtc gtagctcatg
58561 actataatcc cagcactctg ggaggccagg gtgggaagat agcttgagcc caagagtttg
58621 agaccatcct gggcaaacat agtgggaccc tcatctctac aaaaaaaaaa aaaaaaaaaa
58681 aatatatata tatatatata tatatatata taattaactg ggcatggtgg cacacatctg
58741 tagttccagc tacttgggag gctgaggtgg gaggactgct tgagtccagg agtttgaggg
58801 tgcagtgagc tgtgatcatg ccattgcact ccagtgtgga tgacagagca aaaccctgtc
58861 tcaaaaaaaa aaaaaaaaaa aacagaaaag aaaaagaaaa acagaaatca tacaatttat
58921 aatgttgctt ccaagctgca cttgtgaaaa aaagctctta caattcagat aacttcctcc
58981 acatttagtt gttaggtggc cttgggtaaa ttacttagct tatgtaagtc cggttttcaa
59041 aataatagca cctacttagt agggttattc aagagttaaa tgaaggagtg cttaataagt
59101 attagccatt ttcaaaaaat aaaataagca aaggtgaaga acgtaacaca aaataagtgg
59161 tcagtaaata tcacagtctt tccccctatt taaccacgag aaagagaaac catgagctga
59221 tttaaatcag cctatgtgtg tacacccatg caaacttcca tattacaagt gaatggtgaa
59281 gggagatgtg tataaagtgc atttcaaatt tctcagaaaa gcatactgat taaggcattc
59341 cttattctag tattttttta cagttttaat tttcaggaca gacagaggta tttatggaag
59401 tccaggagaa atgctttctt caacaacaag cacatgttta acaatttgga caaaatgagt
59461 caaaccttaa agcagaaata tatcataatt taaacagcca gaaacttcca aagtaaatga
59521 tgtgtgttca taaaatgtta agaaggcttc aaaaggtcat aacacttaaa gggtccagga
59581 attcagtatc acttcatctc atattttagg taggctgggg aacttccagc ctacaggcca
59641 gatttagaat ttgatcagat ctgaagttgc tgctcgatcc caggaactaa ttttcaccac
59701 agggagttct ctgaatattt cagtccaccc agagtatgtg taacccttaa aaggttagat
59761 attagagtag ctgaagcgct atgagcaaat agcccatgaa taaacttttc aaagagcaat
59821 agaaaacctg acttagtgaa aaatgacttt caggtaagtc atttaatgac cttagactga
59881 taaaaggaag agttttgaca tgatgatatt ccagtacaga agaacaaagc ttgataaagt
59941 taacacatag cactgtagtc caagtgaatt gtaagagtat gatttccaca cagatcaacc
60001 tcaaaacctt ttcccagttt ctcatcttcc tttctcactg tcctgtccta ttctttcccc
60061 agtctttcat ctttctctct accaagctgt cttactttgc ttagttagaa tctttcagta
60121 gccttttcat ttaccacctc tccattctct actacatata ctagttatgc cattaaatta
60181 tttaaaataa cttgtatgcc tgtaatccca gcactttggg aggccgaggc gggcagatca
60241 cttgaggtca ggagtttgag accagcctga ccaacatgat gaaaccctgt ctctactaaa 60301 aatacaaaaa caaaaaaaac aaaaaacttg tacttagtga ctaaagttat atgtgccttc 60361 tgagtttttt aaagctttat tttatatttc ttcacgggga gaaaggaaca taagtcaaat 60421 tgtttcttcc tacatattct agaaaaaagt tttttaatgt aaaaagtttc cttagttctg 60481 ctctataagc ctctgagtag atggcttgaa attttaaaaa tcacaatatt ttatgccaaa 60541 acattaatca tattaaacat aaagttataa ctaatgctgt agaatttgat ttgcgatagt 60601 aattgtgcac acactgttat aacaggaata gacttattct aaaagacaaa tcgtattata 60661 aaagactctg cttagaaatg gtttagtttg agttttgaac ttaaatagca cattggcagc 60721 aacagaactg caacagctta gttccatggt attttcgttt gaagcttcca atggctcctt 60781 gtactttaaa gcacttattg ttgctggcca caccaaagat tcaaaggcag ttgtgtggac 60841 aactgtatca tacaccaaaa ggatatattt accgacataa gcccccaatt taaatgggaa 60901 aataaattcc tgtggatcca aacttgtcca gtggtcaaaa aaattctatt gaaaatcttg 60961 cttacatttt ggctcaaagc ataagttatg aatcattcac aatcaccata gtggtgaaac 61021 tagcattctg ggcaacagga atagctcaca tggtgctcta cagaaaaatt aaacaacttt 61081 atcttgacat actatggtcc a taaaagcc atttagttct tccctgtagc tgataaatga 61141 aataaactta gtttgaatat aatttttctt accgttaaag ggtactgcag ggagccatgg 61201 tcagggacac aggcagacag agggccagcg ggacaggagc caagagagaa aactgtccct 61261 gaaaaaggta tcatcttcta acgcaagtgt ggggtcgttt ttggacagcc attttggaca 61321 agctctggcc tcttgttaaa tgtgacatac tgagtcagag gcagacgtcc ttctgtggtt 61381 attcgcttcc tgtctgatta a ttgttgtt tgttgttcct tcctcctttg ctgcagaaaa 61441 agaaactaga ttggttttgc ttaagaagca agcaagaaaa aaaacctaaa ttaaaaaaaa 61501 ttaaatgttt ctcctcccca caaggtgtaa tacacagcta tttggtacag tgacaagagg 61561 agatgagcac ctccactcag tgaagagtcc aactttattc tagatattcc cacaaaaata 61621 actgttcatg gaacttgaga ttcctttagg aaaattatat ttgaaagtat cactgtaaat 61681 actgactatt ccattgagta atagggaaaa gagtcactca agaaagaaaa gctcttacct 61741 accttacctt atcgcttcat taggctaagg gcttcttctc atttacaggg cattcaagtg 61801 tgtggggaga aagttacaaa tgcaggtaaa gagagcaggt caggtgtatg aaggcaaatg 61861 aggttctttt tttggttttg ttttatttat ttcttttttt ttagagagac agtcttgctg 61921 tcacttaggc tggagtgcag tggcgtaatc atagctccct gtggccctga cctcctgggt 61981 tcgagcaatc ctccagcctc agcctcctga gtagctgaga ctacaggcat atgccactgc 62041 acctggctaa tttattttat ttttatattt ggtagagatg ggatcttgct ttgttgccca 62101 gcctggtctt gcactcctag cttcaaagtg atccttccat cttagcttcc cagattgctg 62161 ggattacagg cttgagctac catacttggc agcaaatgag ttttgaaacg tgattttggt 62221 gcccaagtca gggtaataat atacagctta agtcagctgc agatccatag ctttctatgc 62281 caaatgtttc tgtcccccac acttaatggg ataacagtaa ctctcctaga agatgcttga 62341 caaaagcata gagataaaga gggtggaagg aagaaagtca gatttctcat tattaaagaa 62401 ctcaagaggt ggatggcaat ggaatacatg tagaaaacat tttatcaaaa ccttgagtta 62461 tgtatagaac gatctgaaaa tgctcataat tttttcttaa cccatcttaa aggttcagac 62521 ttacatatgc aacacatagt atataactct gagaaaacag taacagtcaa agaatttaaa 62581 agagaggcat atttcagaaa ctagcttcat tgtaaaatct gaatgttggg tcctgattct 62641 gctaggatca gaggccagag gcatgaaaag aacgtatgtt gtctaacatt gccttacctg 62701 taaagtgatg gaactgggct agatgagtaa ttttcaactc aggtagctgt tgggggtggt 62761 gagcagtgag tgggaatggt gggggcaggg gcctgtagca ttcagtgggt ggggccagga 62821 atgggaaatt tcctatggtg cttatgacag tcccacccaa aataccagaa gtgctcctac 62881 tggggagtac tgggacagat gatgtctaag gatcttttaa actcaaaatt ccctgagata 62941 ggagtctaat tgcatgagca gattcatgat gccaggccat gggcacagtt cctggagtgg 63001 agtacccaag aataagtgac tgagagtcct ctgctttgcc tggagcccct tgaaggcagg 63061 gaccgcctct tgtctaactc tggcctggtg tccacccgtg acttaggtca caaataaata 63121 cctgcaggca tggggctgga cagaggtgga ggcctacagc tatcagccac ttcccgcgat 63181 acaaaccctc aggaaaacag aaaacttgat caactattaa gtaaatgcct gagtgaatct 63241 ttggggaagt ctaattatag ttgggtctaa aaagagaaca tgggcgatat gacaatttct 63301 ctacgtattt tcagaattat tttgaagttc tctaagtaag acaccccaaa cacacacaca 63361 cacactctct ctctctctct ctctagctat ctctctctct ctctctctct ctcagtacac 63421 ataccattca tggctatttc catcccttag gggagtggtc cctaaccttt ttggcaccag 63481 ggactggttt tgtggaagat aatttttcca cggagtgggg gcagggggtg gggatggttt 63541 caggatgaaa ctgctccaac tcagatcatc aggcattaga ttctcataag gagctcgcat 63601 gcacagttca ctttaggatt cttgctcctc tgagaatcta atgcgcagct gatctgatag 63661 gaggcagagc tcaggaggga acacttgctc accagctgct cacttcctgc tgtgtggcct 63721 ggttcctaag gggccataga ctggttggag acccctacct taggaaaagc tcacttagaa 63781 gggagtatgt cacctagaag gctgcagtcc ccaagacatg caagggagta gttgtgtagt 63841 ttgagtctat tcctacagtc aactttggac acatttatca ggtgtctact atgcatgtta 63901 ggacataaat tagataatgt tcctcccctg cttaaaaccc tσcaatgact tctcatttca S3961 cttaaaaagt ccaaactctt aggtccacag ggacccacga gatctggccc ctccttaact S4021 ctctgccttc atctcaagta atattctgcc ttgctaattt accttccaaa tctttctgtt S4081 ccttaaatgc accaagctca tttgcatctt caggcctttt acttgcaagc ctggtactca 54141 cgcctggtac actcatcttt ttgttccttt ttattcttca aatgtcagca aaaatgctct 64201 ccctcatgac ccatttctgc tgttttcttt tatgcatagc atgcgtcacc gcttgacact
64261 gtcttattta tctgtttatt tacttgtatg tttctctcca ctagaattca agctctatga
64321 gagcagggac cttgtccatc ttgtttctgc tgttgcttca gcatctaatg caggtgtttg
64381 actgctgttg cttcagcatc taatgcaggt gtttgaaaat agtgtttgtt gaatggaaaa
64441 gaaaatcaat gtttcttacg aattctacta cagcataatg ttcctttttt tttttttttt
64501 tttttttttt ttttgagaca gagtcgtact ctgtcaccca ggctggagtg cagtggcatg
64561 accttggttc attgcaatct tcacttccca ggttcaagcg attctcatgt cttggcctcc
64621 ctagctggga ctacagtcgt gcaccaccac gcctggctaa tttttttttt gtatttttag
64681 tagagacggg gtttcgccat gttggccagg ctggtctcca actcctggcc tcaagtgatc
64741 tgtccacctc agcctcccaa agtgctggga ttataggtgt gaaccaccac gctgcccagc
64801 ataatgttcc tttaaaagct taagactgtt ccccctgaaa tggtaaataa caaatgccaa
64861 gactagactt aagccttctt gggagaagct gttaaaggga aattttccag agaaaaggtc
64921 agcaggtaaa acccttggcc catcagtggg cctggcagtg caggcagagt cttatgcagt
64981 gcaggtggct tacaccattg ggcaatgtga agagaaaaat ggattaagaa aattgaaaac
65041 aaatagaaca atcagaaagg aaggggggga aataaaaaga taaagaaaat aaggcaagaa
65101 aagctggaga tggggagaga tcatgtggtg ggtagaggag agctacaacc acactgctga
65161 cctcagaggc tttggaagcc acctctgσag tggatgaccc acaggtgctg gatgtaacag
65221 tgctgtctgg ccttccgcag tgaagcggag ttctcagctc agtgtcagct tttccagcag
65281 ccacgttctt taaaaagaaa agaactttaa ggctgcagga gacttgcaga gatcaaagtc
65341 tacatcacca cttacagagg aagaaacagg ggtccagaga agttaggcat cctgctcatg
65401 tcacacagct ggcagcagca gagcagtggc caaagcctgg gctccactcc actgtccagc
65461 gccattaatg tctttagcct catttcaggt tcgggtgata ccacctacct cctttctgta
65521 agtacaagaa gaggcagaag aaagagggtg gagagaaagg ctgtgatgcg gatgggagag
65581 gttgttatac tataaccaaa ggcctgagat aagtggattg aaagcctgga tgaataaaga
65641 caatcacaat tctggactta aagagaattt taaatgcgta tctctttccc atttaatatg
65701 catcagtctg agcttaatga cagagtaaaa caataaccaa taggctcgca gaccaatcac
65761 ataaagaatc ctccatatta atctatagaa ataaaaaacc aagagcaggc agaagattat
65821 aaaacaataa tgtaggtcta gccagtgtag aaaaagtgct gaagaatcac agcctcctgc
65881 cgtggccccc agtcaacatg gactgaatca gtgcaacagt ggcatgtgta aaatatggca
65941 acataagttt taaataattc tggtttttca agttgtgttt ccatgactac ctgttatggt
66001 gcagtatttc cccagtagtg gaaaggtgtt ttataatact gcatcccgca gttctaaaac
66061 ttacattatt ccttcttata ctgcagaatg actccttata gatttttagg gtgaaaaaga
66121 aacactacca gattaaagat atgcattagt tgtaagaatc tattttcaaa atgttaaaat
66181 atgggaatta tttgatttaa aagagcagaa acaaaggaat aatcctctcc accacataat
66241 tatcagtaca gctacataca gggttgatca tttaaaaata atctcagaaa catagataaa
66301 ttaaaaacaa accttgtagt attctgcacc ctgttaatat aaattgatgt aatcttactt
66361 ggggaaaagt ctgcagtgta ttctgttgtg ttttggcagc tcagcaacca ttccccctac
66421 ttataatcac gtccatttgt ttgtatggag aatcatcccg tgctcactct caaaccatgt
66481 gcatccagag gcattcactc ccattccaga cagaggaaaa gcatgtgatt caaggctggc
66541 taatcagagc cttgcattca tttggcccta gagacttctg gtgatggctt gtgatcatca
66601 gaatcaagga aaYttgtagg ctgaggcgag ctctatccct gagggatgag gctggaacca
66661 gatctgttga ggatgtaggg gatgggcctg ctgcactcat cctttgacca catggggtct
66721 aaaaccaaga ccaacaaaat gggaattgga agagggagaa aaaccaagtg ctggtgttgt
66781 tggttgagcc ctgaatctat ctataactga agatggcctt tttctagacc tttaatttat
66841 gcaaataaat tctctatttt atttaagctg gtatggtcac gttttctatc attagcaatg
66901 caaagactct taagtgataa aggaattggt actagaagtg agtgttgaat gtgactaagc
66961 ctaaaatgtg caactggctg atttgaggtt ggggaaggct agcgcaggct ggcctggact
67021 ggaaaattgg cagtccttgt taagtgacaa caaaatagct agttatgctg ccacctattg
67081 actcctcggt ctgagacagg agcctactca tggtacacca ttaatggatt cactggaaaa
67141 gcatttagaa tggtgcagtg tgttggctat ttcttgtgtc ttttagtaag atccacagga
67201 aagagataaa tgtaggctca aaactgacta gaggcacaga gggaaaaaat acggctttgt
67261 taagagaggc ctttttttgg ctgtgatctg caaccaagat gggtgagagt caaataattt
67321 ggagacttgc aggttggaaa acccaaattc tctacagcat gctaacatta gatagagtgg
67381 ggagggaccc gatcataatc ctgagagaca caattccaaa caccagaatc ctgaatactg
67441 aaatcccaaa agatcaaaat cctgaaaata taattctgga agaaataata gagaattatt
67501 tgaaagatat ttatttacat tttaaaggag gatttattta agaaacatat aaaaacatga
67561 cagaacactt cataggccat tttacacaat aaaatagaca ataataacac aaatattttt
67621 gcaagcataa acactcaggt attccaacga cagtagcaca ggtatagaag ttataagcag
67681 acatctgtat tcataaagaa atagggσaag aagagaagtg tacaaatgca tatcactaca
67741 gttggtattg tttgtgccca gctttataaa tttggtcatc tgaaatactg tgacaaagaa
67801 tcttttgatg agatcaataa aaaactgtga catgcagtta ccacataggc agttgcccaa
67861 agagctgaga tctcaagaaa ttttcttcac aaacgcagat ttgtataaaa ggccatctct
67921 tcatttattg aggatgtttc aacattttta tgtatatgcg caatgcttac acacaaagtc
67981 aatgctgtgc tgatgcattt ttatggagtt aaatttgcaa aaaaggcatt taatgaatta
68041 gaattttcca aaagtctctt cacaatgtat atgtccagta ttggaaatga tgaaaagatg 68101 aaatagatgg catagtgaat tataaaaaat catgctgaaa ctttaaaata gtggaaaaaa
68161 aactaaaata agaaaaagaa ctaaaaagaa aattcaacat atgaaaagag tattatgggg
68221 atagattatg ggcaattgca tggagatagt ccgaagagct ggcctaacat gatgcagcta
68281 ttctgtgatt gtgattttgg ggattttaga tgttcaggat tttagacttt agagatttat
68341 actttaggga ttttcatctt tgggaatttc aacattYggg attatggtgt tctggactgt
68401 gtcttttggg attatgatcc agatctggag taactctact ctgactccag gaatggaaag
68461 tgaccagccc tggctaatta aagccttggg ttccctggct gcagtgactg gttcagagac
68521 tacttttgaa ccaaggagat gtagtgagac ttattctaag gtgtgtgggg ctgaattggt
68581 agtatgttat ccacattaga ggtgtggggc tggaatggca gtattatacc cacattatag
68641 acgtggagac tgagcatgaa gccaatgcag taagagcgag gggagcctga gactcaagag
68701 gtacagcaat caaaagcaac atgtgggcca gcgcaggggc tcgcgcctgt aatcccagca
68761 ctttgggagg cagaggcagg cggatcacaa tatcaggagt tcgagaccaa tctgaccaac
68821 atggtgaaac cctgtcccta ccaaaaatac aaaaattagc tgggcgtggt ggggtggtgc
68881 gcacctgtaa tcccagctac tcaggaggct aaggcaggag aattgcttga acccggaagg
68941 cggaggttac agtgagccga gattacgcca ctgcattcca gcctgggcga cagagcaaga
69O01 ctctgtgtca aacaaacaaa caaacaaaag gcaacgtgta gatgttactt ggatcctgag
69061 tcaaataaac taaaaaacaa aaatgaggca attggaaatt tggatattgt tcagatattt
69121 aatgatatta agatattgat aattgttagg tgtgataatg ttactgtggt tatattgtat
69181 tttacaaaga atccctaact tttagagata tatactgaaa tatttgtgga tgaaatatga
69241 tgcctgggct tgtttccaaa gtaatataga aaaggaggga aagtgggtag gggtacaaat
69301 gaaacaaaat tgatcatgaa atagccattc ttgaagctgg gtgaggagta cacagcagtt
69361 tgttacacag ttctgtctac ttttcatata tatttaaaat gtttccataa caaaaagcat
69421 taaaaaaaaa agacttgtgg ctcattccct tccttatcca ctagaggctg ttaaagaggt
69481 ttgcttaatc tagtgtaaaa atgctcagac ttgtagaggt aacttacaga gttacagaag
69541 ttacctttta cttctcaaaa taatttcttt tgctcttgga gaaactggat agaatgaggg
69601 ctcccctaca atggtcaaag aacaagtggt tcttcccaga aaaggagtaa actctcaaaa
69661 tctgaacacc cattattagt ggcaataaaa aagtaaaaat aaaagtccaa ccaacaaaag
69721 aacagaccct tttttctaga tcagcactgt tcaRtagaaa tataatttga gttacgtgtg
69781 caattctata ttttctacga gctatgttag aaatagtaaa agtaaatagg tgagattgta
69841 atattttctt ttaacacact acttcaaaaa tagtatcaaa aaaaccaatg aaaatccccc
69901 caaatagtat cattataaca tgtactaaac atttgaaaag aactatgaat taggtatttt
69961 atactctttt tttcacaaga agtcttcaga aactggtgtt tactttacta ctggcagcac
70021 ttcaagtgct ccagagccac taccacactg ggcaacacaa ctctagacag tgagggcctg
70081 acacgcaggc cccatcttac tcatctttta tgctggcagg atgcctgaat gacacttaac
70141 agatgttcaa tcaatgtcag tcccggaaaa gtcttggtcc acctagagcc aactctgcgc
70201 tttatagtta taaattctta ggaagagttt attctgcttg aagccatctc ttaaaacaag
70261 gaattgacta ggtattgttg gatttgtggc cagtagaaga gctaaattgg cttctcttcc
70321 ccgaggtctt agtgctaaca cttctagtac cacatgtgaa gagatactgc agtaaagaag
70381 ttttaaatta agggctcaga aaaaatacat tgccttagtc tgttttgtgc tgctgtaaca
70441 gaatactggc gactgagtaa tttatgaaaa ggccagatac ggttctggat gctgagaagt
70501 ccaaggtcga ggggccacat ctggtgaggg ccttcttgcc gtgtcattac catggctgaa
70561 ggcaagagag catgcacaat gagaggcagg gaaggaagga aacagaattc atccttttat
70621 caagaaccca ctcttgtgat aactaaccta gtcccatgat aaggacatta attcatttat
70681 aagggcagag cactcaggac ctaatcatct cttaaaggtt ccacctctcc tttgggaggc
70741 tgaggcaggc ggatcacgag ggcaggagat cgagaccatc ctggctaaca cggtgaaacc
70801 ccgtctctat taaaaataca aaaaattagc tgggcgtggt ggcgggcgcc tgtaatccca
70861 gctactcggg aggctgaggt aggagaatgg agtgaaccca ggaggcggag gttgcagtga
70921 gccgagatcg caccactgca ctccaacctg ggcaacagag caggactcca tctcaaaaaa
70981 aataaaataa aataaagaag tcccacctct gaacatggtt gcattcagga ttaagtttct
71041 gacaaatgaa cttcaaggga cacatacaaa ctacagcatt cacggactca aacacttcag
71101 tggctttcca ttttatacca agtaaaacct aaagtccttg ccatgactag caaggtcctc
71161 gaggatttga cactccccca cttcccctct ccttccttga cctctttccc taccttctcc
71221 ccccatctct ttgccttagg gattttgtgc ttgctgtccc ctcttctgag gacactgttc
71281 tcttggctgc tcccctcact ccactcatgt tctgcagtat ttgtgcctga tctgctcttc
71341 ccaccagaga ggcagctcca cgagggcaga gtttgtcttg gtcactgctg ctgccccaac
71401 aacttagaac agtatctggc ataatgcagg tgcttgaaaa tatttgtaag tgaattttac
71461 aagcttccag ctctaagttt agttctaact ttcacttaac ctggggttgt gattatgctg
71521 ctccacgttt ggctctaggc aaaaaggtgc caggataaag tggaaattgt tagatttgct
71581 ctccaaaaag acctggggag gctcttgctt ctcccaacag gttgacacaa gacagccatt
71641 taaaaagaca ataatggggg gccctgccaa cagatttaac gactctttct cacgcagggc
71701 tgtttgccag tgtcaggaag agaatgagtt agaaaatagt gagatgactg acttggaaaa
71761 gaggcagggg aaccaaacta gggtgaaaaa aaagaggccc aggactatct agaaaggaca
71821 gtcccataac ggcttcacgt actcatatcc aacaaatctg cattctatgc ccctgtgtgc
71881 ctgatgccag taccctagat gctgaggaca cagcgtggaa gttcacctct ccatgctgag
71941 tttggcagtt ttgtgctcag caaaaaccaa gaaacaaaaa gcaaacaaat acaagtgctg 72001 aggttggaac atcacttgcc ttatttcttt gaagagaaaa tgatttcaca tgtggaaaga
72061 ccattcatgt ttttttcttt tttttttcta agcactatct tgtcttaggt aatttaatta
72121 aaatgcaaac atttcccagt taccagcatc caatataagt ggcccccagg ggaaaaccca
72181 tgtgaatgat agaaagaggc ttcttgcaac ccaagggaga aactggtgga aagccccatt
72241 ttcacatcct gccaggtaca tacttgtgca cacacactga gagaagctgc tggcatgaag
72301 atagctgtgt gttccctatg gttgctaatc attaggtata aaggccagaa tgggccttta
72361 caattacttc tgggctggtg aaagtagcca tattgttcct tattcagact tctctgtagc
72421 taaatggcta ctcagtatca cctgctggag gacagaacta tatggacact aaaggcccct
72481 cccttggatt ctcaggaaca agggtaaata gctctgcacc tctgggcctg acaccaccca
72541 tctgaacact gtgggaaggg ctcagtgacc taagactccc ctaggggccc tctgactgca
72601 tataagccag gcctggctag tgcagctgcc tgggagaggc agacccaact actctgcagg
72661 tggacagtaa atggtgggca tttgtgagtg ccataagaat ggggggcctt cctgggattc
72721 agatgatctg caatgtacca cactgtctca ctcagtaaag aattgtccca caggaccttc
72781 aaaggtcctg ttacatattg atgtggttga aaaaactatt tctagttatc tgagcctaga
72841 ccttaactcc aatttataYa taaactcaaa atagttattg cactgttgta ttcattccct
72901 gtattttccg gtaatgcaaa tgtcatacaa atgaaatact ttgttttgtt cagatattta
72961 ccaagagtta gttgcccctt tggaaaatca tgagcccaag gacaatgtca atggtgttac
73021 tgaagtcttt aactcaagag agcctgcaat ggcagctgtc acacccaccg tgatcctacg
73081 catacacgca aacacctgac catgtacttt tgttttctga tgagttgtac ctgatcactt
73141 acaaactgaa gttattttat aataaattac tttcatttct cttttaaatt aagactacat
73201 tgatttggag ggaaattgtg tgtgaagtca gattatttta tttgtgaagg ttcactgaag
73261 attttgaaga gggcattaga aaatactgtt attacaagtg ggcacggggt cagtcggggc
73321 tgggagccac tgcttctggt ggtcctggga tgtctacatg tgcctgagct ccgtttaaag
73381 tcatgaaagg ccaatcagac gattctgctc atccagcctg ggcagtggag accaccacag
73441 ctactcacct ctgatcctgt gaaggagctt cacattttgt taccaaacat atcacagagg
73501 cgtgggtgat tctttctcct gtttctcagc agatcctgct tttctcagtg gcttggccag
73561 aacagaattt gttctactcg aatgacccca gattccctcc aagaacttcc ctcctctcat
73621 tcagcttctc tggattcttc aaatgactga ctggggaaac agattgttgg aaaaacactt
73681 tcgggttgcc tcgatggggt caatacctta tcaggccaca ggaaagacaa aggaaaatgc
73741 ttcctgctgg agcatgtgca catatgttgt tcctttaact ccaaatacgt atgcaggggt
73801 ggtggtagga tcagaaaatg tgtgatcaga aagtgaccag ttccccacca ttttgtgtgg
73861 gttttatttt ctttctgctc cgtgttgact cttttcccca caacacggaa gctgcttaat
73921 ccaaagactt ggaccatttc attctgtttc agatccattc caacaaaatg atcagttggt
73981 ggcttatgta aaaagcagct ccatgactac atttaaatat tgactagttt gggaataaca
74041 aaccacaaaa atttggggta taaaaaccac atgtggttta tgttttgtag gacaccctca
74101 ggaagataaa tggacaaagt agaaaaaaaa tataaatggt ctctccctgc ctcaccccca
74161 ccatcattaa ataaaaacaa aaaacacaca aaaataaaat gaaacaatga ttaaacaaaa
74221 ctcaagctgg gtgctactcc tggctttgga tggcagttgt gtcttggcaa ggcaagttaa
74281 gtagtggtct gggaactgtg gctaaggtca acgtgtcaga atagcccgac ataacctcca
74341 ccttggtcaa cagctcaccc agctcctgac cacggctcct ctctgtcacc agcacttcct
74401 ccttccagat gagcttctcc aacctctagg tccctgcagt cactgacctt ttcccccaga
74461 tctggcccca cactcaacct cccggccctc ttctccagcc aaaagaaaaa cgcacaaaac
74521 tgtagatgac tttctagaaa tagaagtgtt ttataatctt tgtgtgtctc taatgccact
74581 gttaactagc gagcagctgt gctagggctc catgcacagc agccattcaa caaatactca
74641 gtatcttcat gttccaaggt tgctttaggg gatactacaa agattaaaca gacaaaattg 74701 tccaccgtca tggagcttac actcctatct gcgttgatga tgtgtggaag gaaatttacc 74761 ctctgtttta tgctgtgcag gtgttcattt aggcccagct catattatat tatgaagagc 74821 agcctcacca agatcactgt cagagcagca ctaatccagg caaactagga tgcaaatgga 74881 aagggctcca aagtcctttg ggggttagtc gtttcaatcc aaggaccatt tccataaaac 74941 aaaaacaaaa acaaacaaac aaaaaaactt gatgatatat tgctaggcca gcccacaaaa 75001 gtatatttag ttcataatgt cactaaacta aaacttcagt tctgagtcct caaaggaaag 75061 gactttaagg tggtatcagg aggaggagga gggagggtcg tccctctctg gggctcccca 75121 gcctcagctt ctgcctctgc ccccaccttc aggccacctc caaactttcc cttggtctca 75181 tgcaagacac taaggggctc ctgtccccca aatatttctt accctaaatt gtaattccct 75241 ttcctgggat aagatgatct cattgaggca tcaggaggaa atcaagttgt cttttattta 75301 aaagagaaga gaggtgttaa cccatgttaa cccatatgat gttgaatttt tttgagatca 75361 gagaagacat ttagttggag gaagacacca catagtacag tcacacactg tctagggtta 75421 actttgttaa gtttctccca cttttcatag tttgattcct tcacttaaat aactttattt 75481 ttttttgaga cagattcctg ctctatcacc caggccagag tgcagtggca tgatcaactc 75541 gctgcagctt caaactccta ggctcaagca atσctcccac ctcctgagta gctgggacta 75601 caggtgcatg ctgcctcgct tggctaattt ttacaaattt tttatttttg tagagacgta 75661 gtcttgctat gttgcctagg ctaccttcaa actcttggcc tcaagcaatc atcctgcctt 75721 ggcctcccaa agtactggga ttataggtgt gtgccaccat accccaccta tttttaaaaa 75781 tcacccatta atacccagag aaaaccagtt atcatcttag aatttctttc cagtgttttt 75841 ctttcttttt gtgtttgtat ttaaaatggg atcatacttt ggatgtgtac gtgcgtctgt 75901 atatatcctt ctttttcaca tttccccata ttattctctt aacacaattt taatagttgc
75961 atatctcatt ttctggatgt tctattatct atgtaaatat tttttattgt tagacattta
76021 aattgcatcc aatttcatta ttacaaatcc tattataatt aatatacttg catctgaatg
76081 ttttgtaatc attttatagt atttccttag gataaatttt tagagtacaa tcactagaag
76141 acatgaacag ttttttttta aggaatcttg atacatacga ttaaattatt ttctcaaagt
76201 tttagcttgc atactcccat cagtactcat ttcttctttt taacatgtgc tattatgacg
76261 tttcaaaatc tttgccaatt tgataggttt atttattgtc ttctccatta ttagtatatc
76321 ttactccatt agtggtttgt tatctggatt taaaaaaaaa tcacagggat ttagtctttt
76381 ccttatttcc tcctatttga acctaaaggt tacctaaaag ctccatgatt tttcataaac
76441 aaaataaaat attctaacca ttcgtagact gactgggtgg aaggcagtga ccgtttctgt
76501 gtgtttataa aYcaaatgtt cataaaccaa ggactacctt tattttatta gctgtggcta
76561 attttgtgca gtctatgaga atttttacca ctgtaagaaa tgtttctatc ccatgctggg
76621 aggagagggt aggacctcta ggcacatctt accatagctc ttcctgcctc aaaggcaaaa
76681 gcaggaatgc cttggtttat gttatgcaca tgcagaNgtg taaacttcta aagtctaagg
76741 tacagaaaac agcagttgtg accctgagtc accttatttt agtgttcaca agaccaaagt
76801 tcccagaaat caaggtgtaa tttaggctga cctaatgaat actcaagctt ctctcatttt
76861 taccattttc attagccatt atgcaaatat tttagaaaag gtagaatcta gtttagaatt
76921 tttttatgat tgcaaacttg atgataaaaa cctcttttga gcacaggtca ttcaaagcaa
76981 ctctagcagt ctacttggtg ggctgtaatt tccagttgtc ctgggctaga aggacaactg
77041 atctcctttc cacctggctc ttcccaagtg aagacctgtg acaggatgtt cctcactttg
77101 cacagttctt catcctgcac ttaggagata tttgatattt ctaaattaga caggcagatg
77161 ctttgagatg aagtgcctgg tacatactaa acactcaaca acattagcta ctattacgat
77221 tattaagtga gcagaacttc tccccagttc gtgctacttg gtaaaagagg aaacaagggt
77281 aggttgggca gggagggcaa gattgataag taagaaggca aacatgggaa cacagctggt
77341 aaagtggctc cttttgttta cagagggata attcaatgca atgtaagaat gaagactttt
77401 ataatgctga gttatgggtt attttttaaa attttaaaca aaaaagaata aataatttac
77461 tctttgatat ttgaaaaaag taggtgctaa tcatttgagt ctccatttat gtcatttatc
77521 taaaactcat tttcagatac acttagccct atttaaaaaa gctgcactga tccattcaat
77581 ttgtgctggt cactctcatt cactaatacc tctgtatttt tgtgtaattc caaatatcac
77641 tagactcaat gaacacaaat tcagaaagaa aatgccctac aaatttccta aaaacacagt
77701 tgctcctaaa agttaagaaa cRgggattaa taagttggtt ttatgttcat taacttgttt
77761 tcatttcacc tggagagagc cattgctaat tagtagttaa gttaaaattc caagagccga
77821 atgccgagcc acttgtctcc aaatcctcca ctgcagagaa caggactcct cttcatttca
77881 ctaagaaaat gttcaaaggc ttttcggata gtctcaccca actagggaat ggaagactgc
77941 ttattttcaa gtctgcttta ttctagtggt tgaggagtaa acaaagagaa cagtaaacgt
78001 ctgggaatgt tttcagaggt gacacataaσ aaacagagag aaaataggcc ttgaggcaag
78061 atctgattta actacgtaag tgagaaaaaa aaacatgcca caattcctat cattattccc
78121 aagttctgcc accacaagct gatggcattc tgacgtgaaa ggtactagtg ccaagagtca
78181 aataaagctt tggcaaaatt gaacaccaca cagaaaacag agtatccaac tctcattgtc
78241 agggcattca tggaaaacaa gtatgaagat caatatgaaa tcttattttc caaagtacaa
78301 aggcttctgt atacagaatt tcctactatc caagctatac tcttaacctg ctgcaaaaca
78361 ccttgtggag gtacatctta ctcttcacta gcattgttca ctgcaatgct ttccaacctc
78421 tgtttgcacc aatgttgaga ttaagttttc tcctatgttc cctctgcccc aatatcttga
78481 gaatatagat gagagtttct cagaagttct aagatgcaca aagatgagaa tatctcaaaa
78541 atatttacag cataagtaac atggagaagt tcaagcaatg gagaacaata gcgacatata
78601 ttcattctac tctggattct gtgacatgta tataatcagt cttaaaagcg cagctttaaa
78661 aaagttttaa agttatgact ttattctaaa atgccaccaa accataataa agacagtgta
78721 caatatatta cttagggaag aaactgatac ctgttattgc tttgctagaa tttgggctta
78781 aaaaaaaata aagttgataa aaggatgggt caattcagtg gtgatttgcc tcaaggataa
78841 ctcctcccac ttcctataca aaataagcaa ttacattaaa aaaatacagt cagaatttta
78901 tggaatcaca tcagttttta atgtatgaat cagagaacat aacaatcact ataaatgtag
78961 catggttatg tattttaagt ctctagtcct attttcctta gtgtaggcat aaaagttctt
79021 aaaggcttag aatttactct taaaatacta taaaatatta ctatttttat gacaaaagca
79081 atttatgaat ttatggaaaa ggaaatattt ataaaatatg ttagtaaaag cactgtttat
79141 gtttgtatag caacatttaa aagtattcaa aggtcattca ttgctaaaaa tatttaaagc
79201 aaaataaaag ggaagttaaa aacagcttca cttaaacttg cagtttctaa aacttatcag
79261 gacccaagag cctggaagta tcaaagatta agtggaaatc catattcaaa agagttctgt
79321 ggaattctta taaagagaag agcaggcaaa ggtcatcgga ggacattatt ttagctgaaa
79381 ttctgagtat cattcaaaca ggggagccaa tgcttggtat taacaaagtg ctgttttcta
79441 ctgctgagct cagatgacag cccaccctct atttgccaaa attagtggat gagaaatcat
79501 ttcatgaact catccaaaaa catgaagtgc actaataaag ctttactgcc atccctcagt
79561 catcactttg cttggctagg ctggtggcca gcaggaatat ctccctctac aaaactgttt
79621 caaagtaatg acttggagga agtggtgtgc tgataccatg aaaaaaaatt ccctcaaaca
79681 caaagatagt tcaaaaagca tctgtatatg gctcagagga aacaaacagc tcagctcatt
79741 tcaactcaaa agaaacccaa gagaccagtt taccttggcc atggttacac acatgcaggc 79801 aaacttaagg ttggcattta tccagggatt ttgatccgtg ccaaaaggga tgatgagtta
79861 tccatcctga ggtcaagatg gaataaagaa aatacactga aagagaatca tgtgtctata
79921 agaggatttc acaccttcct ct cacgaga cagggaggcc tcgacccctg ctggaatggc
79981 aagtctggcg tcccttcctg aagccactac tagatcagaa gtccactctg agcctccatc
80041 acatggtttc tcccctgctg aggcctttcc agtcttcctt ccacagtgtg gtccttaagg
80101 agctaaggag ggaagaggat acctaaagca cttgtttgtc aagcttgggc tgaaatacat
80161 ctagaatctt taagatgacc aacattgaat tttccatttt tgagcgttta aaaatattct
80221 tcaaattaag ggaatacata agcaataaag accatgtttt actgggtttt gaaaattatt
80281 tagagttttc tgtaaaagca gttacttttc tgagagaaca ggtggcaact gctaccaaaa
80341 tttcaaaaag atccttattt ttattttcaa ataactttta tttgacaaga actttgtcag
80401 taatggtctt taaattcttt tcaatcctgg ctttgtattg ctattttgag gtgtttcttg
80461 ctaactggat taaggaagcc caaagagccc tctggttttg gtcatcaagg aaatttgtct
80521 cacaactgat gatttatttg attttttttt catttttttt aataggaaga caggaaacag
80581 tgataaacct ttaatatctg aaacttgtgt cattgacctt caactacata gtgaggtttt
80641 cagttcagaa catttagggc ccatgttaca tgtggggata attaaaatgt tttaagtgat
80701 gctttctatt cttcaagtgt tggccataat attcaagctg ggtacaagca gcagagattt
80761 ttgtctgagc tcagtccaag ctctgcagtt tctgctgttt gtctttctag gtggcaccag
80821 tcagtcatcc tctgcagctc atgaaaccca gcataacctt ttgggctgct ctggaaaaac
80881 acattgagca ataagggtta gaatactttg tgttcaatgt ttccagtgct actctctggc
80941 caggagaaat accaaatcat aggcatctgg aaaagagaga cagcccagaa agaatgaYga
81001 tgttacaaag cctgtgagca cagacccctc gtacatgttc atctacctgc tgtctgctta
81061 atactgagct ataggcatcg gagcaaatgg taatttctat cagtcatgac tcaagtgctg
81121 gtgtggtctt caagtagcaa tggattgact tccagggagt gaaatgtcat tgttctgatc
81181 accttgtgga cacagggagt ggtgaaaagt tgagtccatg gcagcatcag agcaagaagg
81241 aagtgcggtt ggttggaacg cgcaccctgt ggtggtgatg ttctccatta gcatttccca
81301 aaggtctcac ccagccatag taaattatta ggaggccctc agcatctctc tgtgtagttt
81361 aaatatcgta ttgtattttc ttggccagtc catgaatgga aagaagtgaa taaagatatc
81421 agaaagtaga caaactgcaa tgtgacctga tgcagaggtg gaaagggtgt ggtctggaaa
81481 ggcagaggtt caataaaggc ctttgaggtt tcctttcatt tccacagttc ttagtcacac
81541 aatttccttt gtggatttta acggtaacta ataaggcttt gaaaaggaat cgaattggta
81601 tgctaggtgg gaaatgacaa aggtcatctt gccacttcag cagggttatt ttaacctttc
81661 ttttatactc ttcaagtcct ct ccagaa taattgaaaa tcccataatt aaaagacctt
81721 cctttgtgcc cacattcccc ttctgagatc aactagagct gggctcaccc caaccatggt
81781 caactggacc aggccagcca ggcctcaggc tggagagcag gctgtgagct ggtctgtcct
81841 gaaaagctcg gcacagacaa ggaaaaggta atgcacgagg caactcatgt ccttccttgt
81901 ctcagaagta tgaactgagg atcaaggagg ggcaggcagt tagcactagg gaaacaagag
81961 caggcaaaaa tggacagctg agccagtcaa tcagtggact taagagagga ggggagatct
82021 gccatctcct ggRactgagg gtgcactgtg gcttttcagg tacctgaacc acatcctagt
82081 cccaataatt ctaataatat taatactaac agtaataaca acagtaacaa tgagcatgta
82141 ctgagctctg attatgtgct aaggagtgtt ctaggtgctt ttataagtat tatcaactca
82201 ttcaattctc acaaccctgt aagatacatc tgggtgctgc tgatgctgat gaacagacaa
82261 gttaagttat ttgaccaagg ccacagagct tataagtggc agagacataa tttaagctca
82321 agtggtctgg cttcatgcct ctgctcagtc tgtgcctccc tgtggggcta gtcctgagtc
82381 tcctgtctcc tttattgccc atctttacaa taaagcccct cctattaaag aggccctaca
82441 gagggtcttt tactcttcta ttgtctcaca attagcattt tccttggctc cactcattat
82501 gaatcttatt aactgacaca tacacacaca cacacgcaca cagagttttt gagaaagggt
82561 ctcactgtga cacacaggct ggcagacagt ggtggaatca ctgcaacctc aacctcctgg
82621 actcaagtga tcctcctacc tcagcctcct gagtagctgg gaccacagac gcatgccacc
82681 atgcccagct gtttcttttt tttagatacg gggtcacact atgttgccca ggctggtctc
82741 aaactcttgg gctcaagcaa tcctcccacc tcagcctcca aagcatgaat gtagttttga
82801 atccagtttt tgttatcctt tcatgccact aaatattctt tgaaagcatg acttttaatg
82861 actgcattat attcatttat ttaacattta cttaatcact tatttattta acacttaaca
82921 ttaagtgatc acttgagtcc aggaggacga cgttgcagtg attgtaccat tgcacgccag
82981 cctgtgtgtc acagtgagac cctttctcaa aaatagtcat ctagctatct cttactttgc
83041 ttttataatt gtgctaatgt caatatcttt atacacaaat ccttgtgcac aggtaggatt
83101 atgctataga ataaattata gaaacagaag tattggatca aagagtttga acaatttaag
83161 ttcacttgat acacagtgca gatggccttc ggggaaggcc tagaccccct ttggctacat
83221 aaaagctcca gggtctgggc atggtggctc acacctgtaa tcccagcact ttgggaggcc
83281 aaggtgggag gatcacttga gctcaggagt ttgagaccag cctgacagta cagtaagacc
83341 ctgtctctac aataaattaa aaaattagcc aggtgtagtg gtgtctgcct gtagtcccag
83401 ttacttggga agctgaggca ggaggaccac ttgagcccag gacgtcgacg ttgcaagaag
83461 ccatgactgc gccactgcac tccagcctgg gccacagggc aagactctgt ctcaagaaaa
83521 aaaaaaaaaa agaaatctcc attcaccata cccttgacaa caatgaatgc tgcaggttta
83581 gaaaaccttt atcttaattt gatttcttga atgggtcaga ataatgcata catttaaact
83641 ctatgctcct taataaaatg tcaaagggcc atttgcgtgt ttattaagag caaaagccta 83701 taacctacag tctccaatgt tgagaccact gacgccttaa aatgctttag aatttcagaa
83761 atggaaatca gagatcactg agtaaacagc ttcagtgaat atctaaggta accaaaactc
83821 agagaagtta aatgacσtgg gtaatatact tgacttgcaa ctagaatcta ggtgtcttgc
83881 cctgtgattc atttctttag aacagattcc ttcattaacc taatggaagc aacaagccat
83941 tgttaccggg gtgaaagtat aaggaaaaaa actgcacaag aatatatttg aaaaagaaac
84001 tacagttgtt ctaaactcta ttttatcttc atagtaccaa gttagaaaaa gttattttat
84061 agacaaaagt aaaaattcac acctagttac tactttattt tcaagatctc tgctaaaatc
84121 tacaaataat ttttttccta ggaccattaa aatattcagc acatacccat tatcctctca
84181 tccagccaac atttactagg tctatactat ggccagaccc tgtgctaggt gctgtagtaa
84241 aagggggcag agtaccaagg taagaaaaga gggattcatt ttagggacat gtgagcaaat
84301 catcacagtg agtgtgactg ggcagtaacg gggtgcacat gatgccgtgg gggtgccgga
84361 gcaatgaaca tggaaggctt cacagaggca cgtgagctgt gcctgtgctt gaaagcaggg
84421 gaagaagtgg attaagataa aataagaaga ataaggagtg gaggggcagg gcccactgga
84481 gaaggctgct gtcacatgtg gctaaacaca gcagcctggg aaaattagtg ctggtgggag
84541 atgaggctgg aaaggtggtc tgggatcagg cagtgttcag gagtttggac ttcgcctgga
84601 ggtgttagga ctcatgtaag ctgtttaagc agcgatgcca tggtcaaagt ggcgcattac
84661 caagctcatt ctaatggcag tacggggaag gactggagac tctgaaggca ggagctttat
84721 ctgtgttggt acagacaacc aggttgcagg cttaaattag agagaggcag aataaatatg
84781 aaagaggaga tgagtttgag taatatatat tagaaagaaa taataagaca tagagactaa
84841 ttagatgtgt gggtgtcatt aatgagacag gcaatgaagg aggaaggcca ggttttggat
84901 gaaagggatt tgtacacatt gagcttgaga tcgagtgagg tatcagaaag tgaatgaaat
84961 atccagaaag cgaatgaaaa tacaactctg gagatcagga gaggtataag cagagtcata
85021 gatctgaata attagtatac agctacaact ctcctaccaa tctccccctc ccctccaccc
85081 ccatcgccca cacacttgga tacttcctct tgtctgtata taggtagaac agcactgtcc
85141 actaaaaata caatgcaagc cccatgcata ttttgcaatt ttctaatagc cacattaaaa
85201 aagtgatgtg gaaaacaggt gacattaatt ttaagaatat attttattta acctaatgta
85261 tttacaatat catttcaaca ttaatataaa aattactaac gagatatttt atattgtcct
85321 ttcatactaa gtatttaaaa tccaatgtga attttccact catgacccag gccatctcaa
85381 tttggactag ccacatttca aatggcccct gctttggact gtgcaggact acacagtagc
85441 ctaccagggt gattaggcac caacatgaac ttttttaacc cttgaaattt gtggaattaa
85501 attaaatgga atttaatttt actgatgaga gaacaatgag gaagcccgct gggccctcca
85561 aatcactgcc caccccaccc tcccttctca gagggagtgc aaaggggcag tgttacatgc
85621 tgttggaagt ttaggagaca tgaagcatag aaaatcattt cctctaaatg ttgcctttta
85681 ggttattaaa taccctgaca gcaacctgac tgaatttaga gccatgaatt tgttatctct
85741 taatgtggat atatatctgg tctcctgata aatttcctaa ggctgttgtt cctaaacttc
85801 aaatatttgc aaactaactt cataattttg tcatgcctgc ataccaccaa aactatatga
85861 tttgtttaat atttttattt aactcaacta acctaaaaaa atctaaagac atatttagtg
85921 tcatcctaag taactatatc catgaaatca tgaatttcat atgttgttgt acattttttc
85981 tactacacat taaaacaaat acatatttaa ataaagaacg tttatccatg tctcctaaaa
86041 tcacctcaca aaccacctgt ggtatgatta tcaaactttg aaaacactgt tcttggggaa
86101 gggaaaggaa cgtaacacta taggatcccc tctctatgcc gccagtgctc cgtggggtgc
86161 gcctatccta actcaccgaa tccccactct cctatgagca ggctgatggt cactgctacc
86221 cactggttgt ctttcaggct tgcatttatt ctggctgatt agcacttgtg tctgccccgc
86281 ggtcagaaat tttatatggc aacctgtatt aactataagg aaattcttaa caatttttat
86341 ttttgttttt aatttttgtg ggtacacagt ctttgttttg attttccaga ggttacagag
86401 ctgccaagtc tgggatttga gcttttacct ataaacatca caaggcagag gcaactacaa
86461 cacctaccat aatgccctcc taagaggtgt tctatttgtt gttgttaaca aaatgatttt
86521 caattatgaa ttatcttaaa gcccaaagac tttaagaaat aagagttggt aaatttcaat
86581 gatggggatg cgtagtacca aaatggttta aaacaaatgt gttatatatt aacataagtg
86641 cttcttagtg tattaaataa caagatctag tggctagtct aataattact ataatttcaa
86701 atggtaatac atataaacaa tattaaaaga tatctgaaat tgtagtgtgt attagttagt
86761 ctattgttgt gtaataaatt agcccagaac taagtagctg aaaccaataa acatttactt
86821 tatcacagtt tctgtgggtc agagatttgg gcacagcttg gctgggtacc tctggctcaa
86881 agtctatcac aagactgcac tcaaggtgtc agctggggct gtgttcccat ctgaaagttt
86941 gggggagaaa ctgcttccaa gttcactcac atgttgttgg caggattcat ttcctgactg
87001 gctgttggtt acaggtctcc ctcagttctc tgcacatgca tctctctata aggcagctct
87061 taacacggta gctggc cc ctgagagtga gcaagagagt gagagaaagc tcctaagaaa
87121 gaagccaccg tctttttata cccaaatctc agtctatgaa ctagatggga aaaatagtac
87181 ctctttttca ctaacctcta gctgaaattt tgcatttctt tgattatgaa tgtagccaac
87241 aaactgcagt agcattaaca gcactgtgac accatcacca atagagctca tagatatttt
87301 atttcatttt gtggcaggca gcttataaga tggtccccag tgatctccac ctgctgaaat
87361 tcatgccttg gcataagtcc ctcctcctga atatgcactg gatttaataa ttcacttttg
87421 gtgaatgaaa tgtgttaaat attaacacag aaaaaacccc tgtgttaaag gatgcagtct
87481 atcttgcacc atctgaaaaa tcagtctggt gctttgtgga tgggcacagg gattcctcac
87541 atacccctgg aatccaccat ctgtgggcat ttactgtgtt tgtgaaagat tcttaaaaaa 87601 agaaaaaaaa aacatgtggt actgctagtg cagctcagaa atagatcaac tttgaaaact
87661 tccctcacag ctgcaaaagg caagtgtttg gcactaataa atcagaatta gtggagctca
87721 actaataatg aacctttcat ctcctctggg caggtggtca ccaactgaac tatgggagca
87781 aacaagccat ggttagatgt aataaccaca tttctaatga caggtaggac tagagcagaa
87841 agtgagtgga ggagaagtct tcccgcaaaa ttcaaatctt cttaaacttg gggccctctg
87901 aaaacattaa tcaaagttgt gtttctaggg gctgggctga cctctgctta ttacctttcc
87961 agtcataacc actgcaggta tttttcttct cgctagtgaa aaacagcctg ggatgctatc
88021 gacaggcccc tatcagagaa ccagtgaact agggacacaa ttataggttt caattttccc
88081 ctcctagacg ccaatccaaa tttgtcatca cctgttcaga gaaatgcctt ccatgtttca
88141 tctcacttgg gtggaaattg ggtgatattc aaaatattta acaaccaatg aggcacaggc
88201 actaaccaat taggacaaca taagatgctg gagcagggtc caggggcacc ctgtgctgtg
88261 ctggcattca tcctttagtt gttgaattat gggagaagtc ttaggggttc tgggggtgtg
88321 ctcagggggc tgagggtgat gacaattcgc caactggttt ttaggcatct cattatttta
88381 atacccagga tgtctgcacc agtgcacaca agattgaata ttcactgtgg aggggggttg
88441 gggctgctgc tcccaagggc ccccatggaa ggctactggt gtggaagctg accccatcgc
88501 cctacagcgt tctgacaact ggcactatgg ggacagagcc ctgtccattt ttctgagccc
88561 tgagctcagg ccagagcctt aaggtcctgg accacttcca aggcttgcag aacccctcac
88621 tcaggtctcc ttggggcggc tggctggcag tctcccagtt accaggcact ttctgggagc
88681 agccagggac agctgctgcc ggctggcatc aatgggcttc tgtgcaactg agggttgagt
88741 ggaagtttcc ttgtgggttt gatggagggc atgttctcag tccacaggtg tcataccacc
88801 cgagtagcct caccactgta caggatacag gcctaagaaa agacttggct catgaatccc
88861 ctcacttcga ggattggttt agcaacttcc tcagctttct gaatgaggtc tcaggtttta
88921 ggcttatcac aaaggagatc attctgcatg acctcttggt ctgcattatt tcactgaaat
88981 gcccgggttt gttttacttt actccatgct tctggaaagc aggctggggg gctctggatg
89041 cacatagacc tgggtctgaa ttccagctct gtggaatgca tcaccacttc acttcacctc
89101 tctgaggcaa tttccacctc tgtcaatggg gctcatggga gtgcctgcct cataggctgg
89161 tggagggtcc aatgagataa tttaaagaca aatttgataa ctgttttctt gtaagttgag
89221 ggaaagatta attcaaaact tttagtctca gtttgggcta ggaaatgcca gtgttattcc
89281 agggtactaa cataggtatt ttaaaaataa gatgcttttt gctttcacaa gctgactaaa
89341 aagtaaagac aaaaagtgac ttcagaagtc aaatgtaact caatagtctt acatgcttag
89401 atccaaccca gaagaactca gggttctcct tcctgaatga agataatttg aagttgcata
89461 tttcgatcca tagttggctg aacccacaga tgcagagctt gtgaatatgg agggccagcg
89521 gtatctcctt ttctacagga agacggcata gtttaattca ttaaaatttg taaaactaca
89581 taatatctgt ttcaatgaca aaaagcaatt tcaattatat ttaagatgac atttacataa
89641 acataaaaat tataaccRtc tcacaatact ctcaactacc ttgacataaa agcagaggaa
89701 agcttgattt gttaaggtat tgcttttgct cattttgttt aaaaaaactt ctttttctta
89761 aaataagaat tatggaatca ttaagtttta agcaataaga agcaaagttc gaaacaagaa
89821 tcctgattct tcacttctgt ttacccaaaa gaacattctc tctctgattt cagtcccaga
89881 aatcaaacca gtgaacacat cactatgcag agtcacattc catgttttta atggaagttt
89941 tagaagctac agatgaattY aggagtgata ttaaaccaag accattaaga aagatgactt
90001 ttttctagga ttctaactcc tatattcaga cacacatatc caactgccca cttgacatct
90061 ccacttggct gtctgtctca tagacatttc aaactcacta tatcccaaac aaaagtctta
90121 gtatctcccc tccaccccaa attgctgtac tcacagcccg ccccatctca gtctgatggc
90181 atttctattc ttactacact taggccactt cctattttcc ttaactcctc tcttttgctt
90241 attatttttc aatccaactg ccaatcttgc tggttctacc ttcaaaataa ccagactcta
90301 attactcctc aacatcttta ctgctaaccc ttgtccatgg caccagcatg tctcactgga
90361 gtatttcaat agcctcctaa ctggtccttc tcttccactc ttgtgctccc acagtctatt
90421 ctcaatacag tggccaaagg gagctgttaa atttaaagtc agatcattgt ctctttttgg
90481 atcaaaatcc tcccctcact cccagactct ggggggaaag ccagagtcct accatgacca
90541 acatggccct ccaggatctc acctccaaat tactggctcc atgttactcc ttgaatactc
90601 caggcatgtt ccgcttctgc gtcctcaggc tttccccatg tggctacatg gtgaattatc
90661 tcaccatttt ctccatgaca gctgccctta ccagctcacc tacacccatc ctccaccact
90721 gtgctctgct cctcctagcc ccgctagact tctttctcca cagcatgtat cccttctaaa
90781 ttcctaatat acatcaccta gtatttttta gatttattgt tttttgtcca catcttttaa
90841 cttgaatata agatccacat ggaagatact taataaataa atctgaatta agggaaaatg
90901 ccaaacaaga aaaacaaaga gaaaaaactt tgaaaacatc cagtgtccaa aaaaaggtct
90961 tatgattttc ttttcttttt cttttcttct ttccttcttt ctttcctttc tctttctttc
91021 ctttctttct tcctttctct ttctttctct ctttttccct cccttccttc ctcccttcct
91081 tccttccttc cctccctcct tctctctttc tttctctttc tttttttttt ttgagacagt
91141 cttcctctgt tacccaggct ggagtgcagt ggtgtgatca tggctcactg cagccttgac
91201 cttgacctgc tgggctcaag tgatccccct gcctcagcct cctgattagc tggaaccaca
91261 ggtgaatgcc accaaacctg gctaattttt aattttttgt agagatgggg tcttcctacg
91321 ttgcccaggc tggtctcgaa ctcctggctc aagcaatcct caaggccatc tcggcctcct
91381 agagtcctgg gattacatgc atgagacatc acacctggcc aggccttgtg atttctaata
91441 gcaggaccca tgtattacat ctcatttttt aattttaata atgtttgtgg cattttgaag 91501 aggagcaaca acaaagtaag cctgacactt aggagaggct gctgtttacc ctgaaaagac
91561 ccctaagagt ggcattcttg gggaggggta gaacactaca tcaagcacag agcgttatca
91621 tagaggtccc cacatctccc ttttatctgg gagccagagg gatcagactc agaatgtctg
91681 agtaaaaatt cacaagaggc tgctgggcac cccggaatct acaaaaaaat gccatttctt
91741 tccagtgacc atgtccattg tccagaatat acctttctga gctaatggta cccaggaagt
91801 tgacttagca ttcagaatgt ggttcagggg tgttggaatc agtgctaagg atggctaacc
91861 cttctgagga ctgcttaatc catgccgtgg tgagccctga taatgcatca caacagacac
91921 ttcacaaaag atcttcatcc atacttacca atccacactc atgtccacaa gattcaggac
91981 ctattttcca ggccaatact gggcaaccat tggaaatttt tcctctctgc tccatgagga
92041 ccagttcatt gcccacaacc tttctccagg taggatggat tagctttcta cccacaaaat
92101 tccaaccata tggctgtgct gtcttccagg aattacgtag agctcacttt gctggagttc
92161 tggaagttcc tcaaatcttc aatctgttac tctactccca ttaggcacag atctggcctc
92221 tgtagatccc agaggtgcac ctactttcag attcccaagt ccttggggcc cttcaacatt
92281 tcccccttat gtcaccagtg tgtagccagg ggccttgttc tgcaccctct accatcatta
92341 atgagctact ttgaccatag acaaatcacc taatctctct gggccttagt ttccaaatct
92401 aaaaataaaa ggatataact ctctaaggtc ccttctagtt gtaaaaaatc caagattatt
92461 tttttcctac ctctttaaga tttaaatgat gacaacagca tctttcctaa acttttcctg
92521 aggccagatg ttcctggcac tgaagtagag gaaaaaaata gtttttgaat aacctaacat
92581 ttttgσcttt tagagaaaat tatcctctgg cctttttagt tccccttccc ttacagctac
92641 ctccttatgg acccttaaag gaagtcttta aaacatagag aggctgaggc aggagaattg
92701 cttgagccta ggggttcgag actgcagtgt gccatgactg tacctgtgaa tagcaactgc
92761 actccagatg gagttcggca acatagtgag tctctctcta tcaaaaaaaa gtaaactatt
92821 tatccttcct gattcatcag gatcttataa aaaacattgt tattttccaa attatttttc
92881 ttacataaaa cctcttaaac agttttattc tgataactat gctcatcagc cttgactttc
92941 ctctgt tttg cagggaaggc tattaaatgc tctggggaag aggaataaaa agctcagaga
93001 cagggccagg gaaggaagca tgctgtccat gtaggtaaat tctgccctga gctttcacaa
93061 ggtgatgggc atgaaatggc agaggcgaaa gtagggagtg gagagaaggg gaaaagaaga
93121 gggaagaaga gaaagtctga aagcatatat tgtttgctta gaaaaaagtt ttaggagagg
93181 tctggtggca gttcaagaat gttcacttag ttagatgact tctaaactgg gacttgccta
93241 agaagccaca ctgcagggag gaggcggagg tggaacagca gttctcttcc tttagcagcc
93301 ctccatctag ccttccgcgt agcaggctgg tgaggtattg agcagcccct ctattggccc
93361 cgcacccagt tttcagaagt taagttcatt ctacaggtct ctaaatgctt caaggacgac
93421 caaatctatc cattgttggc ctggaaatca aagaagacat tccaaatctt caccattcag
93481 taaagσagtg acttactgaa agaattacag tttactagca aaccccccaa atgaatctct
93541 atgtataata catgcataac ttcctagtct gaagatagca gtattccaaa taattgtagg
93601 ctccaagata tcacttagtg acttctaatt taggaaacat atgctctaga gaattcctcc
93661 cattatacac acacacatac acacacgtat atttgtgtgt gcgaacacat atcctactat
93721 aacaaatgac tctgttttta agccactcta ggttacaaaa caatacaatg agttaactta
93781 aaatatgtca tattaaaatc tgggcatgaa cgcaactaga aaggaagcct aattcatacc
93841 agaaaatatc aaaacaaagt ctggtaagtg tctagctagt tagacagtct caaagcagta
93901 gcttctcatt agcattgaga aataacaatc tgagtggtaa tgtgaatacc tactgtggaa
93961 ctggtactgg atgttgtata agctgggaac agatgcctct taaattcagt ttgttgcact
94021 atgacagggt tctacttcaa ggactcatct tttcccagtt tattcttttc caggaaaagc
94081 tttctatgca ctttcataga caaatgcaac tcttcttgtc attttctggt tccttttttt
94141 gggagaaggg gacaYttaga gctttttttt cccctttaaa cagcaccaac cttctgactg
94201 atgacgaaat agagggaaat tgaaatggca gagtaaaaaa tcaatcaggc acataggcaa
94261 tcccttccct ggtagagtta cagagtatac attagtattc atgatatttt agttaggaga
94321 caacatctcc agcaaaagaa tcaccacaca gcactgtgtc aggccgtcta tcacatcttt
94381 cctaccactt ccttgcacag aatctgtaat ccaaacacct accatggtca cccctccaga
94441 atagccccat tggtcttgct ccttttcctg ggacaacagc ccaagtcccc tctgcatcct
94501 tactgctcag aagcaagaca tgaacatttt gtttgaggca ttcctgaaga aaaatgataa
94561 tgatcttata atatgaggta tcttcaagtt tgtgttttgg gaggaagagt ggtataagaa
94621 gacacaattg ctggataatt ctcagaagcc aaacatagaa ttacctatga ttcagcaatt
94681 ccacttctgg ggacatacca aaggaactga atccaggatc tcaaagatat gtgcaaaccc
94741 acgttcatag cagcattagt cacaacagcg aaaaagtaga agcagcccaa atgtccactg
94801 atgaatgaag ggataaagaa aatgtgatat atacatacaa atatgtttgg ccttaaaaag
94861 gaaggaatgt ttgacacgtg ctaacaacat ggacggacct taaggacatt acgctaagtg
94921 aaataaagca gaaacagaac gacaaatatt atataattct acttatatga ggtacctaga
94981 aaagtcaaat tcataaagac agaaagtaga atggtggctg ccaagagctg ggggaaaggg
95041 aatggggagt tgttgtttaa tgggtttaag tttcagtttt gcaaaataaa gagttctgga
95101 gattggttgc acaatatgaa tatacttaac gctactgaac tgtatcttaa tggttaagat
95161 ggtaaatttt gttatgtgtc ctttatcaca attaaaactc ccccaaaacc tatagttctt
95221 agtatttccc aatatgatgg tgataacaat aataccttac aaatgtccgg gaacttcttt
95281 ctgagaaatc cagagacctg ggcctccaga tttgttcatg ccaactcaaa acgataccaa
95341 ggatgagttc agttgtaaaa gttgcactta tcagagttta actttctttt ccccactagc 95401 atgaatgttt ggtatatatc accattttat ccctctgaaa ccagggtcac tcagacatct 95461 gtggatgtcg acccgcagtg ccactctggt attatctggg attcagggag gagaggcctg 95521 cctatgttga ggaagaagag agatttgtga agttagcctc attcctcttc tatttagaga 95581 gttcaggaat gtgtccatac tgttcctccc cacaaaattt accatttttt ctccagatta 95641 aaggtgactt catctctttc cactttgacc tttaaactYa actcagtatt caacttggca 95701 gtcattccta tctaaaaatt acacacaaga ttaatactcc aggtgctctc taccacccaa 95761 caggatctgt taccttctgc cattctgtgt ctccactcgt tctttcagaa cctggggatc 95821 agaggttttg tataatgatg acactttata agccattttt tgcatctcaa acacaatgga 95881 acacagcgca gtgaaagtgg
ADAMTS2 genomic sequence (SEQ ID NO: 6)
>5:17ϊ 695251-17888 4700
1 gggcctcggg ccagcactgc ccagcgctgg gaagacagga gaccacaccc caagtggctt
61 tgacacaggg cgtgtccctc ttaaggcaca gaggagaagt gggcagccag ggctggggat
121 cctagggtgg cccctctgtg ccccaccctt ccccaggcca cttacacgtg gccagtctca
181 tgggccacca caaacgctga ggagaagccR tcctcatggt tcagggtgca gctgcggacc
241 ggatggcaca tgccggtgac aggagcatag cctgggagga gacaagaggc ggctccagat
301 gctgccatag cctggccggg aaggtgaggc ctggcctaac tcccaggcgc tgcttctcct
361 caaggcccca atgccctctc taccacaggc aactgccccc ggctggcaca gctcagaaga
421 caccacagca gacagctcat agcctgtgac atctggctga cagcaggccc ccagcccgtc
481 accacacaag ccccgtggcc gttctgcctg taacagccac actgcagctg gggccctctg
541 cttagtcaga tgtcacctgc tatggcttgt ctgacacctg actttcctgc ctgccgttct
601 ctttcacgcc acctgcctct gccccctgcc tgcctcactg agtggcccct gagcagcacc
661 tgcttccaca cctctctctg ctagaggcat cctgcccctc gtctgcctgg tatcacaccc
721 tccaagccca cctcctctgg ggggcgtttc ttgggtctcc ccgtgtttct ctggggtcct
781 tgagacccta gctagacctg tttccataat gccgcagaag gctgcaaagc tgttcagccg
841 atgggccaca ctaccctgca gaatatccca gcagggggct ggctggtgcg gactgggagg
901 tcagagccgc cgtagaagat gaggccagtg gcctacgaca gcccagggcc agggggaggg
961 tggcagaagt tcatgacgca gagaccccac gtcaaactga ggaagatgga taatgagacc
1021 tattcacttc cccagctcct gtctcagcag agggaggcgg cttggaaaga tagggaagtg
1081 cctacagggc tatgggtgcc acacgaggtc tctgcttgta cccctgggag tcttcctaga
1141 ggcctgccaa gcatggagcc ctgactttca gaaccccaac ctgccctcac tcctgccatg
1201 ccccactgag agaccctgag gccacgcgtt ccacagagaa gggaaggagg gccactggga
1261 ccccgggtga gctggcggtg tacgcgccta aaaatagaag catcgtgatc taacccttgt
1321 cttttcccgt tgtaataaac aggaaaatct gcattttttg ctctgcagat tttgagacga
1381 gcgtggagtc tgtgtgcctg agtggaacgt tgccatctcc tctttgccct ttgtatgcca
1441 ggcttgcaga tgcatctgcc tccgtgggag gctttccatt catcctactc agcattacag
1501 gagcctgcga gatctgaaag cgcatcttta tgtttttctt tgttttcttc cctcttattt
1561 tactttgtgg ctgttttctc tctccggaat cttattagat agagtgtgcc tcctcgatgg
1621 agggtctgtc tcctaacttt tctctcatgt taatcttttt gtcttttgct cccattggga
1681 gatggccttg actttttatt tcagctttcg attttttttt tttttttttg agatggagtc
1741 tcactctgcc gtccaggctg gagtgcagtg gtgtgatctc ggctcactgc aacctccgcc
1801 tcctgggttc agtccattct actgcctcag cctcctgagt agctgggact acaggcaccc
1861 gccaccatgc tcagctaatt tttgtatttt tactagagac gggatttcac catgttagcc
1921 aggatggtct ccatctcctg acctcgtgac ctgcccgcct cggcctccca cagtgctggg
1981 attacaggcg tgagccaccg cgccccgtct acctttcgaa ttttttactt cccccatcct
2041 atccataatt ttatacaaat ggtttgttgt tctctaattt ttcatagaaa actcttaggg
2101 tttatggatg tattttctca aacattctgg gaatactact tttaaaaaca tgcttttctt
2161 gtctctaaat tatctctatt ttctcttaga gccagttttc aaactttttg ttttgtttta
2221 catcttggtc catctttttc atgctgtaag gatttcttgt gttttggttt ttttaaaata
2281 tctggtaacc cttggctgtc ctttcatttt ttcttttttt tttttttttt tttgagacag
2341 agtcttgctc tgttgcccag gctggagtgc agtggcacaa tctcggctca ctgcaacctc
2401 tgcctccggg gttctagtga ttttcctgcc tcagcctcct gagtagctgg gattacaggc
2461 acctgccact acactggcta atttttgtgt ttttagtaga gatgttggcc aggctggtca
2521 cgaactcctg acctcaagtg atccgcccgc cttggcctcc caaagtgctg ggattacagg
2581 agtgagccac cacacccagc caatttcaca tttttaaatg agggatcagg tcacttaata
2641 taaaagctgt gtcggtttcc cctcctaggg gatagctctg ctccccatta gtgccctccc
2701 caagacaaaa cagccaacag cactctcatc acatggtcag ggcaacacct ggctgcgctg
2761 tgtttgaggg gagctatcca ctcctcaccc agacatggta gtttcagtct ttttaaccta
2821 gctatgctat taggtgcgtc ttgatatttc attgtgtttt taaattttcc tttttttttt
2881 ttcttgtaag acaaggcctc gctctgtcac ccaggctgga gtgcagtggt gtgatcatag
2941 ctcacttcct gggctcaaac aatcctccca cctcaggttc ccgagtggct gggactacag 3001 gcatccacca ccatgcccag cctcattgtt ttaattgcat ttttccaatg tctagtgagg
3061 ttgagtgcct tttcatatgt ttattgctca ttcatatttt gtcaagagcc tgataagagt
3121 ctcctgccca ttatctgact ggattgtctt tattatcctt attatgattt gtaggcgttc
3181 ttcacatact tcagatataa atcctttttt ataaatattt cccccagtgg attagcgtgc
3241 ctttaatgca caaacttttg aaatgtgcta ctatttatca gttttttcca ttgagttcat
3301 ggtttgtttg gttttttttg tctctttttt ttttgagaca gagtctcgca ctgtctccca
3361 ggctggagca aagtggtgcg atctcgactc attgcaaact ccgcctcccg ggttcacacc
3421 attctcctgc ctcagcctcc cgggtagctg ggactacagg cgcccgccac catgccctgc
3481 taattttttt gtatttttat tagagacggg gtttcaccat gttagccaag atggtctcga
3541 tctcctgacc tcgtgatcta cctgcctccg actcccaaag tgctgggatt acaggtgtga
3601 accaccgSSc ccggcctttt gtctcttttt aaagaaaaca tctcttactc caagaacatg
3661 gagccatcca cctacgttat cttctttcat tattttgcgt ttcttattta gacctaaaat
3721 ccatgtgaga tgctctctgt ctatagagtg agtggaggtg acaggcctcc tttctttcca 3781 aattggcccc acaccatttg ttaggctgtt ttcctcctct tctctgaaat gtcacttttg 3841 tgacacatta gcgtccctat acacataggt ccaattcagg acactggatt ctcttctaat 3901 gatgtatttg tccatcagtg cactgcccca caccctcacc cagctaaggt ggccacggcc 3961 ttccctgccc tgacactctt ccctgggctg ggccaaggct cccggggccc cttgcatggc
4021 caggggctca tttccagctt cacgcctctg tggccctgca tgggtgaggc tcaccttgca 4081 tgccggaagg cccaaagtcc tgccgtgtga ggaagatggc gtgatcgtgg tattcatcgt 4141 ggcccgtgtc tggcttctgc tggaggtagg cccagcggca gacattctcc aggctctgag 4201 aggggttccc gatctcgatg aggctcatgg actgcagggg gatggagaga aatggaagag 4261 agaggttggc gcctggtggc ccagtggggg gccgagcagg ctgtagtgtt gacagacYcc 4321 atccactggg aatctgttcc aggtggtaca aaggccctgc ccggtcactc tcaggacctg 4381 ctcccactgg gctccagtct ttgacaggga agaaaagttt ccccagtcac actcacctgc 4441 gtgagtttcc acacaaagtc accgcagttt tcaggtgaga tgcagaagcc aagctctacg 4501 tcatctaagg cctcgcatag tcccaccgtc taccccattt ccagaagtcc ctgtgtttgt 4561 tctatgaggc acctgttccg tgcaaggcct ccacagaagg caaatgtcat gtggacctca 4621 ccccaaagag ctcacagttt tgggagggtc cgtggcaggg gaggcggaaa ttccagtgtg 4681 gtgtgcaagg ccagaggaag cagatcacct tatacgttcc ccccgtgtga aggtacttgc 4741 agaaaccaac acaatggagg aaaagaaaca gcaactgaca tatttggtgg gtgcaaaagt 4801 aatcgcagta ttgccatgaa aagtaatggc aaagactttg gcatcaacct aatagaaaaa 4861 cagccatatc aagaacaagg gcatacacag atgattccca caggaactat gcatgggaag 4921 cccccgggaa ccatcccatt ccattttgta tcatgacgca cacctgacag ctagggtggc 4981 ctcgggaccg ctcgtcttgc acactctctc tgcaccatga catcagcagg cactcccatt 5041 tagacttcag gactaagaag cctgtcttgg acaggaaact gagactcaga gaagttaaga 5101 agcttgccca ggtcatgaaa ctaggaagta ggagaattga gatcggatcc caagaaggct 5161 gaaaccaaaa tctagattca actcactgcc ctaaacttcc tccttaaata agacatacac 5221 aatatcattt caaaagcaag gcttctgtga gcggcaccct tccttttttc ctccacaatc 5281 ctcacagcag gcattttggt ttctgttctc accatagact ccaaacaccg aagtagttcc 5341 ctccaagaga accgagagcc cctctgagtc ctgggcatgt tcttttcccc tttaaggatt 5401 tatctggcca taaaatagag atgtgcattc cttggaagct acgtatgcag gtgttttttc 5461 tcttgcataa atgtatccac aaagtagagc cacgtatttc tctttgtgtc tataaataac 5521 aaaaagttgg ccgtgcgcgg tggctcacac ctgtaatccc agcactttgg gaggctgagg 5581 caggtggatc acYtgaggtc aggagtttga gaccagcctg gccaacatRg tgaaacccYR 5641 tctctactaa aaatgcaaaa cttagtctgg cttggtggcg taatcccagc aacctgggag 5701 gctgaggaag gagaatcgct tgaacccggg aggtggaggt tgcagtgagc tgagatcacg 5761 ccactgcact ccagσctagg cgacagagtg agactccgtc tcaaaacaaa acaaaacaaa 5821 caacaaaggg tattgttagc aagccagtta gttccagaag aagggagcac aattcaaggc 5881 taggtaagac aagtcgttcc caggggtccc agtcaatgac tgacaagatg gcagaccaat 5941 tcccaagtcc caagcacaga gttaattgta aagactttat ttcctgctcc tgggagataa 6001 gataactcat tctaacaagg tttccatgag tcccgatgaa ataagtcata aatcagagtg 6061 tgatgtcctg tgactaagac ttgtgggaca ttggcataga agtggacaga ccagaggaag 6121 ctggaggagg gcaaggggag gtgcacttcc tgttcccatc atgaccagga agagcatgtg 6181 actagctctg gccaatgagc tgtgagcaaa agtggggcat gtctcttttc ggttggagca 6241 tctaatttcc cattgagacc cttcagagag ctctcctttc tggcacgaga tctggcaaca 6301 taaagacagt ggctgctctg tcacctagga cctgagtgac gatgagaccc gaatcctccg 6361 ccaacccaca ttgaacatac agcgtgagca ggaaatcttg gtcgttttaa gccactggga 6421 tgcaaagtgt gtttgtttct gtagcataac ctcacctact ataattgata caggaggaag 6481 ggagtgggta tctgcatcac atccaagcct gacccctgca gctcatctcg agtccctgcc 6541 aggtagtatc cgcctctggg tagccttgag aggtcacagt tctgaaggag gaatcgggcg 6601 aaagaatgtc ccttctcact gtctccagct agggggtgag cttgggatgg cacaagaagg 6661 aagggaaact cggggtggat gtgattcggt gctagagcgt gggccttgtg gttggttgta 6721 ctcgctgaac ttaagattgg cagcccagat atggatgagc ctgggggacc ttatgctaaa 6781 tgaaataagc caggctcaga aagacaaata ctgcacgctc tcactcatac gtggaagcta 6841 aaacagttga tgtcacagaa atagagagta gttcctggag agtggggggc agcgggctgg 6901 ggattgccaa ggctggttaa catatccaaa agtgcggcaa gatgggggaa taagcgttag
6961 tgccctatag tgccggaaag cgcctggaat ccgtaagaat gtattgtgca ttttcaaata
7021 gctagaagag tggactttga atgttcccaa cacaaagaaa tgataatgtt tgaggtgaca
7081 gatatgctaa ttaccctgat gtaatcatta cacattgcat acacgtgtct aaatatcaca
7141 ccctacccca gaaatatgta caattattac atgccaatta aaaataacag taagagcaaa
7201 atcaaaaacc aaacaagaat gactttttaa catacatttt ttaaaaattg ccagtccaaa
7261 tccaaatcag agggtcagca caaaggtcac taataagcgc ttttgctagg gtggtggcag
7321 ggcccctgct gcagtgtgag tgtctccatc caggacaccc agcacagctc ggtagccttg
7381 ctgggctcca gggaaagggg ccttgcttcc tccagggcac gtctcccagc atcagtgtca
7441 agggagtcct gtccaagatg aactcacctg ccctcagggt cctaagcccc atgtagtggg
7501 acggtccctt ccgatgccct ggtgggttgc ggtgacttct gcctgccctt gtttcccttt
7561 cgtgaaactt cccctccttt aatctgagtc agaccccagg cttcaggggc aggcaggcct
7621 ggccaatccc agcaccacgc cttcctggcc accatgaagg atcagggtga acatacaacc
7681 aaagcgggcc aaggagtagg caaggtgtga ggtggggggc ctgcagcggc tggagccccc
7741 ctgcactaca ggagaccccc caccaaggat taaaggagga tgagaccact gtcgagctaa
7801 gactggggct gcagtctcat ctgaaggctg taccggaggc gggtcagctc ccaggctcat
7861 tcaggtggtc acggcgggcc ccagctgagc tgttgcacac cataccgtat gggcccctcc
7921 tggggccgtc acccatgtca gctttacccc acacggtcgc ccctgctcga gggacccaag
7981 agacaacaag agaaggcacc tcccctacag aagccacagt ctgcttttga tagaatctca
8041 gtcccgccta ccgcagggca tggacattaa gagactgggt cactggcggc catcacgaag
8101 gctgcctgcc actgacgggt gtcatttatg cctgaagaag ttcctctcct tgtgaaagcc
8161 aattctgagt tgtgctcttg tcacttgcag cgaagagaat ctgagccacg tgcttcctcc
8221 tttgggggac cacagggacc ccagtcagga cactcgctgg cccatgaaag atggcgtctg
8281 atctgggggc agctgatatg ttctgggggc agtttatatg cttctcagtg ggagaagggc
8341 cctggccaag tctttgagga ggagtcaaga gtccagccag aaagacatgc cccaatatca
8401 ggaccagagg caggaatgag gctagtgtgt aggacagagc tgcgggagga gccaggctga
8461 ggcaggctgg gggtgtgcag ggaggtccgc tatcctagtg tgtgggcttg tggggagtac
8521 cgggaggatg ctagaaaccc aagcgcctac aggagcaagg caggtgacaa gtcaatgagg
8581 caggctggtt gcacgaaaag taagtccatc ttgtgttttc ccagttttga aggagaaagg
8641 gtacagagga atatttccct attagaatag agtgggggtc ggtgataagg agtggcgagg
8701 actgtggcaa acccaggtgc ccaggcacag ctgaagggag caacatccgc ccagtgctgg
8761 caggaacaga ggcccagagc tgctggatca gatttctcag gtcaatcgtg aaatctggat
8821 tctacagaca cctacctaat agtaaacact ggctcaaatt gaaatcagtt atgcagacaa
8881 aacaacgcat cctccccgtc accactttat tccagaaccc tggaataaga gccctgcagt
8941 ggKcagcccc ttctccacgt cctgcagact ggatccactc tggccgatca cctctctcct
9001 cccagatgct ggcttctgtg gttcagcctg ggttcccagc ccgtcttagc agccaaagtg
9061 atcttgctgc tgcggcaaga caatttattg aaatattgat ttgtgttttt gttcttgcct
9121 cgctttgttc tcggcccagt ccaagaaggc agcctgccac tttcgttctc caaccccaag
9181 gaggttgtgc tgcagggtcc agagctaaag gggtctatga cccccttctg gctttggggt
9241 tctgaggaga ctccctgagg agggggcaga ggggagggct ggggtgcatg ggcacaggga
9301 ggggaagctg cactggggcc aggggagccc tgggaggcag gacttcagga gacatgagag
9361 tgtgctagac cctgggagcc tgggtcccag cagggggtac cccaagaagt agaggagagg
9421 gttacctcag tgtccgggca ccccaggact caacctgcca ctgggagctt aactgacaag
9481 ccacagagct gcttgtgctt cctctctctc tctgccaacg tcccaacatc tccaaggtcc
9541 cagcctatct ctgacgggca cagaggagcc caggggcaga gatcttgtcc ttgctgggtc
9601 tggagcattc aagggctatg gggtacccat gaggcccaga cattgacctt gtgcccagag
9661 gccagggcaa ggtctgtgtg cattcttaaa acagcccttt gggtcagtga ggaaggagtg
9721 gggatagaag gggacagtgt ggcactgaga tgcatgcagg tgtggctggt gccacgtcag
9781 gagggtcagg acctggtggc aggagctgag aggcatcagg gctgcagggc gggagcaatg
9841 aggcagagac ggcaccagtg tctggctttg gggattggta gcaaggcaga agaggcggcg
9901 cgggaagggg acggcaagtg ccagaggaag agcgtggggt ccgcagtgca ggaaacatgg
9961 tcacggcaat gtctttcctg gccagcttgc tcgttgggaa gagctgggct gttttgcttt
10021 gggagctctc ccacttctgg gggtgcagcc cttgtgggtg atcagtccca agccgtagct
10081 gggacccatg ttaggcccat ggagcacagg ttcgaaagga ctgaaaactg gctgaagtgg
10141 gtttgcctgg tggcagcacc caaaacaacc atccgcaaac tcaggctcat gcaccccaga
10201 gccccctttc ctccacccac tcctcccact ccatgagagc tacaggcagc cttgggttct
10261 gcatgcctct aaggactcct cacagaaaga aactgatgtc caggcagaga catcggggca
10321 gctggacagg tctgcggccc aggagggaag tctgggctgg ccgtggacag ggcaaggccc
10381 tcgctactgg aggcagtcgg aacccaaggg aagagccaag ctcaggtctc tccgctgaga
10441 cctccagcca aggatactgt cctgacatgc agtgaactcc cctgtgggtc acttgggctc
10501 cagcgggacc acctgctggg atgcgacctc ctttgctcct ctgccacctg gcctgcatgc
10561 aggaggccag atgggtccct gctgcctggg gcaccccagc ccccaccatc ctgtgccctt
10621 gctatgtatc aagcctggga actgtgcttc ccctgagcga gaagaagaca catttctcat
10681 atatggatct cctccagaag tgagggaggc tgcactgctt gtttccactg aggagtcttt
10741 caccagctcg ccctggtcat ctacgtccct cccagtcctg aatgcacctg acttccagct 10801 gcctgctcgg ctctgcacgg ctcctctagg aaagtctgtc tgtgtgactc cacctgttcc
10861 tagctgtgct gaggggggga ccaggagtga gccgtagcac cctgggctct gcaaaggggg
10921 tggctgcagg accagccagg gactttacag ggcagccagt ccctcccagg ggcagccgcg
10981 ggcacccagc ctccagagca gggggcggta gatggtgctg tatgaccggg gatggacatt
11041 tcgaggccct ggggctgcat ggtagctgca gggtccacct cctgagtgag gcagggcctc
11101 tgagggcaga ctcttcacag cggcagcagc tcccagaact cccaggtcca gcctagggcc
11161 ccagaagagc caggcgggag aagcctgcag tagggctgtg gatgaagtcc aggggcccat
11221 ccagcccagg atgcaggagg agtcctgagt gggctgaccc tagctcagag cacgggaaca
11281 gatgagcttc caagaggctg atcggatcct ctacaggggc cccaggacag tcgtcacccc
11341 tcatggaggg ctctgccacc cctgtttgga ggtgacatcg accactgcag acatgggctc
11401 ccaactgggc tccactgccc gagtgctctg gggccctgga ccaggctggc tcttccagag
11461 tgcagggtcc tccttggcca tcatgagtgc ccacctatgt ccacatggag accctccttg
11521 ctatgctggt tcacagagct gcccagatgc aggaggcaga cactcgtcca ggcccctggg
11581 gccctcccac agcagcaccg ggagcctggt cccaagaagg atggtgtttc ctccgggttc
11641 agcctgtttg gctcccctgg cccgggctgg aaagggtctg aggacatgcc tgaaagaccc
11701 agggatccca ccatgaggtg gagagggcag atctgagggc cttagggagg caagagcttg
11761 atggccctca ccttgggtca gaaggtcact ttgctgaatg ctccccaggg ctgtcaggag
11821 gcttggccag ggcaagggtg aggaaacact gcgggcccct gaacctcagg cccagcctgc
11881 aggggtctgg gtaaccccac gggcctcagg gaacagccag gagcttaggg ggcccgtggg
11941 ccttgggtgg acgagtaggc tgcgtccagc tccaagtccc agccccatcc tggccgcggg
12001 accctggctc tgagctgccc gccgggtccc tcctcctgcg tgcgatcggt cacctgccag
12061 atggggcacc tactggggat gtgcctgttg ctgtcgctgg cctctgagtc actaaagcct
12121 aagctccttg agggccgggt ggttgctggg cccgagtctg tgccccagcc ctggcccacg
12181 cctgccctca gtagccccac tcctcccttc acggagcaat cccggcttct gctctccatg
12241 ccaggatgag gcagcgaacg cggccagagg accccggctg ctgggcgctc agtgatgaag
12301 gaatgaacac gagcaccctc aggagccagg ctgggcaggg agggaggcgc cggctgcggg
12361 gacgttctcg ggaggcctgg ggaagtgagc ccaaagggcc gccccggcag atgctgaccc
12421 cagcaggaag tcaccgtccg caaggagcgc cccgctaggc tcaggcttgg cacacgacac
12481 ctcgcttcca cttcattttc ctaccttccg gatgacgaac tgcgtctcag acaactgaaa
12541 ggactcgcct gagtcccaca gccggaaaga ggtcggggtg ctgccccccg cgcggggcgg
12601 gcagaggaag ggccgggccc gagcggccac caggtggcgc tgctgccgcg agaacagcgg
12661 cccgggccgg ggacgcaccc ggcgcccaga ctccgcggcc gcacccgggc tcccggggcc
12721 ccagcggccc caagacagcc tctgggcctc accctaaata catcaattat gacctgagca
12781 aaaagttctg ttccaatcgt tgctctccga catttccatt gtttgctctg gaaggagctg
12841 aattatctat gctcttccct ccttcagtca aggagacgtg ggaggaaacc gggatgggga
12901 tcagcagcct ggaggccgcc tccgctggaa ccgcgcccgc cccgccagga ggctctgcct
12961 gctgggcaag gcgcactcag ccagccccgc aggccgccac gcgaccgagg ctcaccaagt
13021 ccactgcagg tggcaggtga ggtcacctgg gcagctctag gcccggccga aatatctcat
13081 ctgctctgtt cttgggcaag ttaccttact tgtccccacc tgcaaaatgg gcacaactgc
13141 agctccgagc ttggagctgg ggggcttσcg cccatgacag ttcaggcagg gtgcagtcag
13201 cgcccacaaa tgtcccttgt ccttgtctct gccgtgctgt tgatactgat ggagtataac
13261 accagtccct ggggactggc ctacccgctg gggctggctc atgcccccaa ggggatgcgg
13321 cttcagcaaa gcttctcaac cgtccccatc ccagaggggc cctcctgcct cagaccagcc
13381 tcctaaacag gtgcaggata ggacagcagg gaggttgggt tctggtgagc agaccacatt
13441 tctcaacctc agcactccag atatttgggg ccagataatt cctgttgggt gaggcgggca
13501 ccctgttcat ggcaggatgt tgagcacacc cctgggcact ccttgccaga acccagtgga
13561 accctccccc tagtcgtgac aaccaaaagt ctctccagac actgccaaat gtcccccggg
13621 tggggggagg ggtggcaaag tcactcttgg ttgggagcaa ctgaccctca ggggaccagg
13681 acaaggagcc tgaagctggt gctcctgacc agccgggatc acagagtcca gcccctcctc
13741 ccagagcaga gtggctccac cagcgtgtgg ccccgggcag gccgctcgcc ccctggagcc
13801 agggtcctca ctgtcaaatg gggatgatca cagcgcctac tccacagggt tgctgtgggg
13861 gtgagggcat aaagtcacat aaagggcttc agacggtgcc tgtcccagaa gaagctctac
13921 aaacagtcac ttgcacgaac gcctttatga ttgtcgtcat tcctgttgtg tgctggggtt
13981 tcacagacct cctcttatgg gggaaactaa ggccccatga tgttaaattg ctcaccaaag
14041 gtcccacgag tatggacaaa gccagaatga atggcaggga caaggtccca ccatccctgc
14101 tctgtgagca catgttctac cgtgcccccc agctgagtgc aaagtgggct cccccaaggc
14161 tggaggtctc ttgttccagg cagggcttac agatcaaatc tcatcacgac agagaaccac
14221 gagagctggg gcaggaggcg tgcacctcat ttctctgcca gaactcccat atcgttccag
14281 cattttgttt ccagccatct tccccaaagc ctgggaagct attcccagag agagccaagc
14341 tgccagaaca ggattctcaa cttgagcctt cccaggcatg agccagtgca ggcctgtggg
14401 gaggcagaag aggggcctcc tgctagaatc tgaatgttgt gtcccccaca tttgaaaggt
14461 tgaaagctga gaaccaatgt tatggtatta ggaagtgtgg tctttgagag gtcattaggt
14521 catgagggtg gagtctccat aaatgagatt agcaccctta caaaagaagc ctgagggagc
14581 ctgttcaccc ttccatcatg cgagggcaca gctagaaggt gccctctagg aggaatgggt
14641 ccttacgaca catcagttct gctggcgtcc tgctcttgga cttcccagcc cccagaacag 14701 tgagtaacac aattccattg gttataaatt actcagtcta aggtatttct gttattgcag
14761 cccaaacaga ctaaggcacc tcccaagggc agtgtccagc cttagtgcct cctagttctc
14821 tggacccagg taggtctggg tgaggaggtg gatggaggat gatgtgggtg ggccatcatg
14881 ccttgcaccc ctatcaggtt gggggttggg acccagatgc tcaggaggac agggggctgt
14941 ccctggggtg aggcatgggg tgtgtttccc acctcatccc ctgtcccaga tccccagggc
15001 ccttgatata tcctccccag accttcactt cctggccttc ctgcaccatg gctgggccac
15061 tctaaatcct ctaccctata ggtgggtggg tgggcacacc aagcccccac ccccagcacc
15121 tctcttctcg tgctttccac taagagactc acatgcagaa tttctcagac ctttcacctc
15181 caatgctgaa aaattccagc aagcattcca cactttgtct tgacctggtt ttttataaca
15241 agacacttta tgtccttctc tgatgctccc caagtctctg atttccattt gctttgattt
15301 tcatcatcct aggaaatatt taaaatgaga acagttgagt agctttggta ccttctcaaa
15361 aaatcaattg aaaagccagt tgctatgcaa cctcaagtgt tgccgatgct ctgctccctg
15421 gctggtggta tattgtataa aataagatca tctcttttct tctgcttttt tttaagaaat
15481 ggagaaaaat gttgttttag gaaaaacttg agataactca gaggcttctc ataagctaga
15541 agacaaacat gtcactcaaa caagtgctac caattttatc cccactggag cctggtgagg
15601 cctgggggac aggcaatggg ggagcggcag gtggggagct ggtctatttc tgtcacaatt
15661 tgggatgaat aacaggaacc gagtatctgg gccactttct gcccaagtct gggtcatggt
15721 ctcacatccc ccagagtctg tccccaccgt gggggggaca gctcagcccc ctcctgactg
15781 ccatcgcctt ggttttgcca tgctaaaatt cttctagaga cgggggcctc attccttgac
15841 gggaagcctg tggttccttg aagagcagct catcagaatt catccccacc atgtgccaaa
15901 ctttgtcccc agagccccat cgagaatccc tggctgtgct tctctgtgag caaaaggggt
15961 ctgttccctt ggacacagga gctaggcctt ttgcccccag atcttggctg ggaagtcccc
16021 atcctggctg ctccatccat ggtcccctat tgcctgccac cctgctgtat tccttgccgg
16081 tgctcaccac tctgtcgctg tcttgtctgc tgctactgcc tggacacagg gctcctctcc
16141 cctcctcgtt catgcacctc cctgggatta aacagcagct gctcgggaag ccagaggctc
16201 tgggctggcc ggatgctttg ggggcacaag gatacatctc ctcccacgtt catcagacac
16261 ctcagagacc tgaaaacagg gcctccccca gtgctatgca aagtgaagtc tgtgcctggt
16321 ggacacaaac tgttccagtc cacagtgaga taagtacaga aactagaaac ttttatagca
16381 attggacggg ttgagtttat gtccacagaa tttaataata aaaatccaga cctagagttt
16441 ttggatacct cggtttttgt cacatttgct tttcccagta attcatttat aacgtatggt
16501 acggaagtat tggtctgtga tgggtttgaa ataggaaaaa gaaaacagcc aggtctttgg
16561 cattgaggtg cactgtgtac tgctgctccc aggatggcct ctcccctggc cacctgggga
16621 tggcagatgg ctcctccggt cccacagacg ctgctcccaa gccctgtggc ccacagcaca
16681 ttcgctaagt cagccagggc ccatgaccag aacccatttt cctagccgct gtgccctcta
16741 ccccaagcct tcagcccagc ccctagcagt gccacctcct ctgctctact atttcctgca
16801 cttttgcagt aggtccaacc taaagcaacg aggactcata gcctcggctc acttcccctc
16861 tcacagccca gaacccccca gagaagggca cagcagcggg caggcccggc tcttctggca
16921 gtctacactc agctgatcaa ctcaggagat ccccgggatg gagcggaccc catgggcact
16981 ggcgtcccct acccccatca ctgcctcctg tgcttgatct gggaggcttc taggaggaag
17041 gcggggtagg gccaggcaga aaaaggtggg cagagtatgg ggtgagcttt gctgagcccc
17101 actctgggca ggcatgagtt aggagcagaa aaaaaggccc agaatgctgg aatgttccag
17161 aacattccag gaggccaatc atccctgaat tcccggggtc tgacagaggg accggctgtg
17221 tgttgtcctc caagctaggc tgaggggcct gggaacaggc actggggtgt cctgggtccc
17281 acacccctca caacccagca ctgcctctcc cctgcctcct cagctgcggg tccactgagc
17341 cctcggggcc gggggtaagc tggttccatc tggagttagc tctggaagcg tgcgtccagc
17401 ttccggttct gtcttccaat ccctcaccac catcagttct caagcccctt cccagcagga
17461 ggcggaagca aggccagcct cagttcacct atgtcctctc tgttctcttt gtacctgggt
17521 cgcagaagtt gcccggtgcc caccacaggc atgagctgcc ctggtttgct ggctatggat
17581 ctcagcaccc ccagggcctg cacatgtccc catgttgtcc ctgggaagag caggctgcac
17641 ctgacaaccg gtcccctgcc cactgcccca ttcccaactc tgccaaaagt ggaagtgggg
17701 ccccagcatg gccccagtga agcagagctt ctgcaggtgc atgaggggtg ggggtcccag
17761 caaagcagaa cttctgcagg caaggcgcat gaggggcagg ggccaaggag gccctggcca
17821 ggagggtggt gcctgctaac ccaggggcgt gggcttctca tgcaggggag accacgtacc
17881 tatggcagcc tgcgtcctca ctccaagatt tcccatttcc ttcaggtgga cccgctgcag
17941 gtggaccccc tgccccagcc acaggaaRcg tgagctagcg cccatagggt ggaacacaga
18001 aacctcatta ctcctcccca gcccactgca gagatgacgt gccaagggaa agcatgaatt
18061 ctctttgatg tcttcattga aatcagaaat aaaggactga gcgtgacaga gccctgtggc
18121 atgccaccgg agacctttct ccagagtgct gaattcagtc aaacggcatc atttggatcc
18181 taccattttt aaatgatttt ttaaaaaatc atttaaaaaa tttaaatttc acaaatttaa
18241 aatgcagtgt tttgtttata aaagaaacat gctggtccag gctcagctgc tcacacctgt
18301 aatcccagtg ctatgggagg cagaggcagg agaatcattt gagcctggga gttcaagacc
18361 agcctgggca acagagtgag accctgtctc tacaaaaaaa aaaagaaaaa aaaattagtc
18421 gagtgtggtg gtgcgtgcct gtagtccaag ctacttggga ggccgagatg agaggatccc
18481 ttgagcccaa gagatggagg ctgcagtgag ttatgatcac accactccac tctagtctgg
18541 gcaacagagc tagaccccat ctcttaataa taataataat aataataata ataataataa 18601 aaaccatgct catcatattg aatttaaaaa attcagtaaa gtacaaagaa gaaaatgaaa
18661 attaattagc ctactgccca cagagaaatc ctgttcacat ttgatgtgtt ccttccagtc
18721 tttttggtaa atatatttgt acaccaaatt gagatcatac ggaaaactga gatcctgctt
18781 ttcaaacaac aaacagcttt agactgtaac catttcccaa tgccattaaa catgtttcga
18841 aaatgcaatt ttgtggcagc ctaatactct accacatagg tttatcatta cttaactaga
18901 ccactattat tggacaatat aggttgtttg ctgttgttca catgagagat aatgccatga
18961 cccttgtctt gttcctaaaa cttggcccac agctgggatc actgctttgg aacagagttg
19021 tagaaatgaa tgtctggggt cacagaaatg aatgtctggg ggcaaacatc aagaacattt
19081 taaaggccaa atgcggtggc tcgcgcccca taaccccagc actttgggag gccgaggcgg
19141 atcacctgag gtcaggagtt caagaccagc ctggccaacc tggtgaaacc ccatctctac
19201 taaaaataca aaaaattagc tgggtgtggt ggcaggtgcc tgtaatccca gctacttggg
19261 aggctgaggc aggagaatca cttgaaccca ggtggcagag gttgcagtga gctgaggtcg
19321 cgccactgca ctccagcctg ggcaacagag caagactcca tctcaaaaaa aaaaaaaaaa
19381 agaaagaaaa aaagaacatt tttaagggca gtgataaata ttgctacatt tccttagaat
19441 atctgtactc atactcaaag tgtgcctgct tcattcaccc agccataaat ccctcttcat
19501 cttaacaggg ttgatgcttt ataaatggtg tattatttat ttctttaaca gtagagttag
19561 atatttttcc atatgggctt tctcttagcc acttggattt ttttctttgt ttccttccat
19621 tgacaatttt gtttccttat gatttagagg aggttttata tattaagata tatttatcac
19681 attgcaaatg tttttcctgc ttgtcatttg ccttttcatt gtgttttttg acagaagttt
19741 ggtattatac ttatccaaat atatccatat tcccctttac aattccttca attggattta
19801 tgcttagaaa gctcttgaca accaatattt tcttcttgat ttgtgtgatt taaatagttg
19861 aatgttgtat tggcttatat ttgtcaYatg ataatttaat ttcctattta ttaaatttat
19921 gttatatatt tatttataac acaataagca ttctgtgttt atcacggtag gttatttgta
19981 agaggggtat tttcaactat tttattcaac tgaactgtct atgaaagttt atgcacatat
20O41 ggcactattt taattatctt cactttacaa gatgtttgga ggaagtctct tacttgcttg
20101 ggtcccacag ctgtctcggc cattcttgac cgttcatgtt cctttggagg aagtctcttc
20161 cttgcttggg ttccgcagct gtctcagcca ttcttgacca ttcatgttcc tttggaggaa
20221 gtctcttcct tgcttgggtt ccgcagctgt ctcagccatt cttgaccatt catgttcctt
20281 tggaggaagt ctcttccttg cttgggctcc gcagctgtct cagccattct tgaccgttca
20341 tgttcctttg gaggaagtct cttccttgct tgggttccgc agctgtctca gccattcttg
20401 accgttcatg ttcctttgga ggaagtctct tccttgcttg ggttccgcag ctgtctcagc
20461 cattcttgac tgttcatgtt cctttggagg aagtctcttc cttgcttggg ttccgcagct
20521 gtctcagcca ttcttgaccg tccatgttgc tttggaggaa gtctcttcct tgcttgggtt
20581 ccgcagctgt ctcagccatg cttgaccgtt catgttcctt tggaggatgt ctcttccttg
20641 cttgggttcc gcagctgtct cagccattct tgaccgttcg tgttcctaga tggtgcttag
20701 aatcacttca taacatttcc aactatgaat ctgggaaagg ccaacctctc gattataccc
20761 agcttcccat gaggacagca tttgtgtctt catttgtgat cactttcttc ctatcattaa
20821 tcaggtacaa tttccttcca atgggtccat tgtcttgtca ggactattcc aggtattcta
20881 catttttggt tactaccata atggaaattt tctctccctg ttttccccac taccaaggct
20941 gttgtttttg gttcacacag aagctactga ttttttaaac aatggtctga tatttggcca
21O01 catcaccaga ctcctctcct aactctacaa gttRtaccgt ggattctttt aggttttccc
21061 gacacatgat taacagcaaa caatRagaat ttgtctctgc tcttttccaa tactagtttc
21121 atgtcacata caagtatcta ggattttcag aaccacagta actagtttat gggtcttttt
21181 tgtttgtttg tttccaagac tatctccagg gcagtgctcc ccagagcagg ttcagcaggc
21241 tgcggatctg ctgagcaaga agcttccgtg gagaaagttt tcagagacca cctgtactgc
21301 tcggactctc ggaggtacac catgcacagc tccacaggaa agtctccggg aaatttcacc
21361 cccaggaatg cccattttcc tttgtttgac cagcattttc cagacttctt tgaccttggg
21421 acccctctat agtcctctgt aacatctact catatcctaa gaattcgctg tgcagaacac
21481 ttttagggaa atgtgcttct ttttccgcct ttaaatacaa tσttggttgt cctgttgccc
21541 tctgttacta gttttctggg gatctggaaa aggaggagtg ccctgtgagg ggctaYgggg
21601 ccgtcacgcc cttgccctgc cagaggcttc aacactggag ccctgaggcc tctctcccag
21661 gctcccccta ggcagcaagc tcctcatgcc tgcagttgct tctgctaccc ccagctccag
21721 accccgcagg gctccagacc cacatccaca tcttcttggc ctcctccgct gggatggcac
21781 caggtacctc taactgcaca tctcagctga cctcttcagc ttccctcctg tgctccccaa
21841 tctcaggggt tgataccatc atctacccag ctgagagtct ctccgccttc acccacctag
21901 tgccacatcc tctcgaagtg gcctcctctg tcctcctgtc tgtatccctg gacccaggcc
21961 tggtcccagt ccagctgcca gcatccccca tttgatggca gtgactgtct cctaagccac
22021 tgctcccacc tgccccttct gcacacagga gccagtgatc ttcttagaaa tgcacatggg
22081 atcgtgtcac tgcttaaagc tgccctcatg ggcaagccaa accccttggc gggagacgca
22141 ggtctgctct gctccttgcg atcggctcct tccgacgtct ttggcattgg gtctgctgtt
22201 cctgtccctg tgctcgtccc tctgggttca gctgccctcc ctcccctccc agcctatgaa
22261 ctcagagcat ctctatgctg gtgacttcac tggaccatct tcaggtgtgg gtggaacggt
22321 cacttcctcc cgttgctttt cctgaccttg taaggaaaga ctgcctgacc cgcgtctcct
22381 ccatccagcc ctgagccctg gtacaattgt ttccttgtct agatctgcct tctggaagcg
22441 gtcccctgag gacagagact atgccagtga atattcccag cacagcactt cccacacaga 22501 agcccttcaa acagtatttg ttagaggatg agttttgtca tttggaaact gatgtgatga
22561 actgtatgaa tagatttcct gatattaaac aatctccaca ttcctaggat aagccctaga
22621 tgatcacggt agaagtttct ctttatacat tattcaatta aactcttaat gccttgggat
22681 ttttacttct atttttagaa gtgagacagg tctgtacttt gtcctgacgg gctacctttg
22741 gcatctttgg gtataagggt cccattgact acgaaagaca cattgggtag atttcagaat
22801 acatgagttt acagggtatt gtattagtct tgcctgataa atgcttgcaa atgagtatga
22861 atgcactggc aaaactttgg aaaaggtgaa gaacttgagt tccctccatg gttatgggac
22921 ttatggcata ttctccattt tttggagtca gctttgaaat attcacatcc caggaaatcc
22981 tcaatttccc caggatctcc gtgtccctgg catagagatc ctcaaattct caccttcagg
23041 gtttgactct cttctgcaaa tgttctgact gtgatcacat actccttcta cctacctgag
23101 gcagttaagg aaaaaaaaag aaaaagaaaa agaaaaggct tagggtcggg ataatttagc
23161 atagagcctg ctaaggagta attaataaag gaggctttat tccatcaagt actcaagact
23221 gggaaagagc agacactttt caggccaaat aagatccaaa gctttgccag cactggtaag
23281 caattaaccc tagtcaatta caaaattctt ctttttaaac aatgtaggag caacctgggg
23341 gaaaatgcaa gccgccacct ggcacccaga ccaatcaaKg ggataatctt ttctcccctt
23401 tctagcccca ggaccaggag tttcccattt tKggaaactt ccaaaagagg atataactct
23461 gtccatctct catgccaaag gcttgagaat tcctaaaaca ccagaggatc ctggccagga
23521 agggacaggc tggaaagacc cggcttgggg aaggccggaa cagggaactc cactggaggc
23581 aggcagccag ccacatggga tagtccaaag atcccccccg cacctccccg cctgtgaatg
23641 gagagctgga accggattgc tgggctgggg cccaccccca ggctctgcat ctgtgtggtc
23701 caaagccccc tgccacaaac ctgggataga gggctcagcg agcctctctc tgccctccta
23761 gccagcattc actggcagag gatgccctgc acatccctcc tccactgatc atccctggac
23821 ctccgaagtg gccggctgca gagagcctcc caacagcttc ctagtgggca gatggccctg
23881 catgctttcc tttctgccag gagaagtatc tttttgtagt cacattacat atactctttc
23941 tgatctttta gtttgtgcct tctctctttt tttctagatt aaataggtca gagggttgct
24001 ttttccMaag ctctcttctt cattgattct atgtgtttct tccattttct aatttattga
24061 tttctgcttt ttctgaacta tttccttatt tttgctttcc ttaagttttt ggttttgttg
24121 ctgttgaaat tcattcaaat gtactgagtt gaaggcaggg ctaatgtgtg tcgaacatat
24181 cacccaagga agaagctttt ggaaaacatc tgtgaatttg cctctgaata cagctttaac
24241 cacattccaa aagatttgac agtagtgctc ttgtttttat tagtgttcca aatagtctgt
24301 actgcagtcc taatattctc tttccttgct ctgttaccca ggctggagcg cagtggtgtg
24361 atctcagctc actgcaacct ctgcctcccg ggttcaagca attcgcccac ctcagcctcc
24421 caaatagttg ggactacagg cacatgccac cacacccggc taatttttgt atttttttgg
24481 tagagacagg gtttcaccac gttagctagg ctggtctcaa actcctgacc tcaagtgatc
24541 tacccacctt ggcctcccaa agtgctagga ttacaggtgt gagcgaccat gcctggcccc
24601 tagtaggttt tttttttttt taatgttttc aaatgaattg gattttttta ggtttataaa
24661 ttctgctgcc cccaccccta cttttaggca tttcatcagc gaagatggac aaaatcgttt
24721 tagctgtata aaattcacaa tattttcttt atgacccaaa acacttctgt aatttttaag
24781 tgttctatga ttcctcgaaa agaaggttca tctttctttt tttctgtagg gcaagggaaa
24841 cagtgatata actactaatt tagctttact cattgtgtca ttcaaaaatt ctatgcctta
24901 ttagcatcta atctgtgaaa ggcttttaaa agtgtattag agactctcat agttaggttt
24961 ttgccaattt cccctttgtt ccaaggattt gttttgggat gttttgtgtt ctcttggggt
25021 acacgaaggc ctgcaactgg catccgccct gtgggtgcct tcggtcactg tggaatgagg
25081 tgcttggtgg gtgtagggaa gtggccccaa atctacttag tattcctggg atcccttctg
25141 ccaccggagt ccttcgtcat catttttaca tcgtgtgcct tataagttgt atgcagtttg
25201 attttatttt ttgagactga gattctcttt gaacagagtt caacttttat ataattatct
25261 gatgtatttg atcctattat gatttgattt tctatgcaca gσcagaccac aggctcgaat
25321 tctgctgtct gggtaagaag cctgactcct cgggtgctgg atggccctgg ctgcttacct
25381 gggcatgtca ctaagtcaca ttaagcctcg gtgttcttat ctgtgaaatg ggcagagtca
25441 cagtgtgcac ccctccatct gccctgtaga ttaagggcat tcatccatac aaagtgcttc
25501 ccacacggct ggtacaggca ctttgcagtc tacacgggcc gtaccgtggg gctcctctct
25561 tcctctgtct gcacagcatc ccgtgttgcc atcccaggtc actgtccctg gcggctacac
25621 acccatgcac accgccagga aaggacgtcc caggtttggc tgcaagagga agtgggacgg
25681 gcaagagagc ccagctggga cagcagccga ggccagagga gaggaggcca cagatttaat
25741 acgggggcag aagtccaagg gagggtcgtg ttaaccacgt gtttctgatg ctttgacatc
25801 cgagccttgc tgactctgga gggactgccc cgctaagtgg taaccaatct ttagagacag
25861 gaaacaactc atccatgagc acatttttca gatacaaacc aaccaatcca gcgcccatgt
25921 ccccagccac ctcctttatc agacttcaca ctctgagcca ctatccccct gccctcatta
25981 cccagaaaac taactcagga ccgctccact ccccagagcc cactggaatt attcaaactg
26041 gccaacctta agccagctca ccctgtcccc atcggtcctt cctgcagaaa caacatggac
26101 tcaggctgct gtttacccaa Ytccctctgc ctcctgacca cccctggtgc ctccctgtgt
26161 ggcccccgtg gcctggtatg tctcttcctc ttgggatctg ggagtaacag actcttttca
26221 gtgaacaata gtaatggcca cattttaaaa caaggggtga aagggagcag ggWtcttgtt
26281 tcttatagga acctcagggg agccagggag aggcagggtg gttctggcaa acgcacacac
26341 tctccaagga ggcccatgcc tcactcccag gcccctcact ccgagggggt ggaggcaggc 26401 ccggctggcc acagtgcact cacctttcca tagctcagga ggatgatccg caccaggacc
26461 acgttgatgt gggcacccaa ggactcgtca tggtagattt cattgacctg aaagaaacag
26521 ggaggcatca gcgggaacca caggccctag gactggctct ggctctgcca atgggatgac
26581 ccccacctgc tccttcttct tcccatgctt tccacccagg cgtcaccatc aactaggagc
26641 caccttgtga cccctccctc attgccccct gccctctgcc tctccaggct gccaccacca
26701 cetgctggga tcactgtagc cccttcctga gcaaccccac ccaccagccc agggWttcct
26761 cacctggggc ctgaacatgg aacgtgggca gggaaagcag ccctacgctt gctgtagcct
26821 ccagctgaaa cacaaccttc ccttcaacag tgaacgtggg tgatggaccc ccgcggcaca
26881 ggcagggctg ggaccggccc tggcagaagt cactccaagc tatagctggt gggtgtgggg
26941 attacctacc tgcatcgcta cttggaaatg ggggcggttc taggcccacc accaggtata
27001 atgttttaac gtgttaataa aaagctcata ttactgcatc cccaatgtgc tctccctgtt
27061 ctgttttgat ggctggagct cctgcagtcg ccgtctctgt atttatcaca atcatattct
27121 tacacgtgtt tcattcttca catttaaaac cattattctg agcaggtgcc aatgggcttc
27181 agcagatatc aaagggaccc gtggcacaaa aacagggggg tgaactcccc ttctacagaa
27241 cacagccagc aagaccctcc agaaacatag gtcaggttat cccgggctcg aggctgtcag
27301 gggcttcctt cgcactgagc ccccaccctc cagcttccca ccgcacacac ccagggccct
27361 ccctagcgca gcccccttcc tgtcacctcc tttgttggtt aaccaaaccc Yactcctcct
27421 cgaggccagc tcagcagtca cttccccctg gaaggccccc cgcaggcctg agccgcccct
27481 catcaagcac aaggtgtgtt atttctggag ccctctgtgt gcccctgtgg gctgggcagc
27541 cacctgcatc ctccctgctt gcatgcccag agccaggcta agcagcacct ggcaggcact
27601 cagggatacc cgctgaaagg ctgaagccat tggcaccatc aagaagtgga gaaacaggga
27661 ctggctgtgt gcagaccgag cccaggggct gctgacagct ccggacatg ccaagacata
27721 cttcccggag cctgctgcca cgtcaggcca gcacacactc cctgcactcc aatctgtaga
27781 gcctgcatct gagcaacagt gattgctacc tcaaaacagt gggaaggcac ctcaggaaac
27841 c"Ygagggttc acaaggagaa tgacatcatg atggatgggt ggacaggcat acagggcgtg
27901 caagacaagg atcccgaggc ccgctggcat cggtgctggg aacaaagatg gcaccgatcg
27961 tggggcagag ttcatgacat gtggaccctg ctgagggtac catccagccc aaacgcagct
28021 cctcttggca actgctgccc agcaaatcta catctgattg taaatgggct ccccacaact
28081 cccacctctc tttcctatag gcaagggaca actcatcaga cccacgggag cgtggctggt
28141 caccgtggct ccgggctgta ggcgtctggg gagggtgggt cagcaacccc tgtaggcgct
28201 gagggttatc ctctagaccc ccagtgaccc atctcgcccc tgtggctgac aagatggagc
28261 tccgaggagg gcacccaggt ccccaggaag ccttgccatt tggtcatcgc cctccgtttc
28321 ctctgtaaaa tgaggattgc agtcccccca tcacaaagct gttgtgggga tgaaaccgYc
28381 atgcaggtgc aatggaatgg tgcttgtgca aacaatgaaa cggtttttσa ttgctggtaa
28441 accatagtgc cctgcagctc cctgtgaggt cctgggggta gggtatgcac ccctaaacca
28501 cagaagtcct tgcccagctt tgagggtcag actagattgt ttagtccacg ctggcacagt
28561 agccttaaaa gccagttttt cttaagagag aaggggtttc tgtaattgtc cacagtattg
28621 ctttctctat cacgacaaag cttggccagc ttggctcatg gagtctgacc gagggaaggt
28681 cccactgcag ctgaagggag cagaatagga gagaggagaa aggccaggga tgaggggcca
28741 ggcttctcct catcctcaac cccaacctca caggtcatac agaacagtcc tgacatctga
28801 gaaggaagga aatgcaaaag agcttgatcc tggctgctgc ctgggacctg agaggggaca
28861 ggttcctagc agtaggagtg gcttccaggg cccaactggt ggcccagcct gctcaggcct
28921 gagagggtgg cccagctccc agctgtgtgt agcagatgcc agggtcccct gcaccccaga
28981 gacacatggg caagatagtt ggggactggc ttgcaggttt acctggctct agggggcacc
29041 accaggcttc agggcaagcc caggggggca ctggcctaca ggagaggagg gcaggcctgc
29101 ttgcaaggct actgcagagg ggactcatcc ctactgcccc ccaccaggcc tctgcctgca
29161 aatggggctt ttgggaggta attaggggta gatgagttca tgggggtggg accctcatga
29221 tagggttagt gtcctatagg aacagacacc agagagcctg catcctctct ctctgccgtg
29281 ggaggaccca gcaagaaggc ggctgtctgc aaaccaggaa gagaatcctc actggggaat
29341 gacccagctg gcaacatgat cttgaaattc ccagtcttca gaactgtggg aaatgaattc
29401 ctgtgattta aacccctggg tctatggcat tttgttatac cagcccaagc ggaatgagac
29461 aaaggcttta tggggaagag actgagccac ctcccacagg ccagactgca gccttccttc
29521 tatcctgggg ctgagtgccc gagatgaggg cagcaccaga tataggaacg aaagaaagcc
29581 ctggccaggc gcagtggctc acRcctgcaa tcccagcact ttgggaggcc aaggcggtgg
29641 tcacctgaa gtcagaagtt caagaccagc ctggccaaca cggtgaaacc ctctctctac 29701 taaaaataca aaattagcca ggcatggtgg cgagcgcttg taatcccagc tgctcaggag 29761 gctgaggcag gagaatcact tgaacccagg aggcggaggt tgcagtgagc cgagatcgcg 29821 tcattgcact ccagcctggg agacagagca agactctgtc taaaaaaaaa aaaaaaaaaa 29881 aaagaatgaa agaaagttgc atttttcccc acgtttgagc ctaagcgtgt aaatgttgac 29941 ctcaccgtcc acacagaccc tcagcacagc cacgggcccc tcacaggctc tcaatgggac 30001 ttctcaaact aaactgaccc tggcctcttg tgcagcccac cacaccctgg gacccagaat 30061 ggcctgggcg agcctgacct ggtctctcct tccccactgg gctgaggctg gcacccagca 30121 gacccagcag aaccactgcc tcaccatgaa ttgtggctct gagtagatca gagccagccc
30181 tcctgccagg aggcggagag ggacactcag atgctacgag accagctcca ggatcaccgg 30241 cctcgaggga aaggcaggga accagaggat atattagtgg gaatctgccc actggggcct 30301 ggaaggacgt ggcatgtcat gagacctgag aaacagaaca gggtagctca gcaaagcagg
30361 gatggcgctc ctggcagagg aggcagccca tgcaaacctc ccagggttgg aagcagcgag
30421 gcaccttcca agcacagagg ggatgtggaa gggatgcccc agcagaggag gtgggagggg
30481 agcactgagg ccagaccacg aagtcaggag aaggattcca aatcctctct aagagcagtg
30541 ggaggacatg gaggaaggat gatggcgggg catttaagaa gcttactcca ggtgccttac
30601 ggaaagtaga tggaaggggt caagatgtgg gaatgtgggg ttcagctttg gggatgagtg
30661 cagagaaggg acggatgtga gggatgatgt ggattggaat aggggtcatc tgccccgcct
30721 gagcagggag aggctggggc tctggaaggg cattccggca gctcccacag ggcggaggga
30781 ggagatgcgg ggctggccct ctcctggctc ctggccaggc cctgcccctc aggacgcaag
30841 atcttcccac tctcctagcc ctacccctgg ggccgaaggt ggcagctctc atctcaagaa
30901 ggaatcttgt gtccttctga acattgagca gatctaatcc tgctccctga tttgggacag
30961 gaggtgacca accactccaa aagccccgtc gctgggcatg gaactccctg ggatagaccg
31021 tcagcctcac attctgcttg gaggtggggt cgaggcagct gagccctggg gtgtcaggct
31081 gctaggcgtg ggcccctggc tggggagctc cactgtgggc tgtccgccag cagccagctc
31141 ccacctcctg cgctgggtgc cctgaccctg gcctctggaa gcctcagatg gttcggagat
31201 taactggggc tccctggctg ctgaggagct aSagagggca tgcctgcaaa tgctcccagc
31261 aggtagccag ggagaaggag gccaggccgc agccaaggcc ccctcagccc tccctccctg
31321 gtagccttca actgtggtgc gctctccctg atcctctccc caggaaacct ctgtcccttc
31381 ctcccttcca caccagcaca gcacatagtt ccccaggcat gcccactctc tgggaggcag
31441 gcctgagcaa ggccgtggtg gggcttgcga tggcctcctg gctcctctgg gtggctgctg
31501 ggcYtgggat cctgctccgg agccctcaac ttggccccct cccaggccag gtctcagcag
31561 cccctcccag cagt caggaa ccccatgggg cactgtggcc cagagaccac tgaccactgg
31621 cctgggtggt tctcctgccc ctgcgtgtgc tatggcaaag tccaacccac agtccggggc
31681 cgggctcctt ctgctgtcca gcctctcagt ccccgtaggt taatatgata catcaggaac
31741 agacatgggg ggcaggcagg gtttgtgggg catgtgagag gcaggggtgc tccacagtgt
31801 ccttgtcctc cgtgggcctg aggagtgagc cccgtcctgc cccctctacc atcccagggc
31861 tctacctgct tttcaggagg ctgcaaaatt gccaaaattt cctgcccagc cctggccaga
31921 ggcctgcagg gcccacctgg gcatgggaac cactgggagt aatcagtgta attcccgaca
31981 aaacactggc gtcctcagta aggacacagc ggcaacattt ctgcagagca gagagtcgac
32041 tgatgtggca aaaagagcaa ctgaagacag aaggcgacct ccacatgcct gcctcctgca
32101 catccccctc ctcσcccggc cccacccact ttctctgcca gacaggagac aggcggtagg
32161 gctccccaac ggtccccctc gtgtcctccc caccccccca cccacacaca ccattcttca
32221 ctacgatcac caagcggaat agatctcacc ttccccttcc actgtctaaa accctcaacg
32281 gctctccagt gccttcggaa gcagggccca gcccctcgcc tggcattcgg agccctctcc
32341 acgctggccc tggctggctt ctccatgcgt cacttcagat acctccccac atggcaccct
32401 tgctcctgac agcccagcca gccttcccca gagccggctg ccctctcctg ctgcctgtgc
32461 tttggttcag gcctggaatc ctcactctcc ctgtgcagcc cctcaattct ttagatatct
32521 caggagcatt tgaaaaaaaa gactcatcct aaaaaatata tctcaaagga aagaggcagt
32581 gaSctccttg cttaaaccct tcctacccca aggcatgaga ccgcagttcc tggcgtgacc
32641 tccaggccag gagggtctgg ccctgctgag tcttctcggg ctgccctggc cctgctccct
32701 gtgctccagc ggctagcccg gctgctcctt gcacaggcag cctgtctcca cctcaggaac
32761 tttggacttg ccgtgcaact gctcccagca gtgYctagcc catagtaggt gctcagtaaa
32821 catttgctga atgaatggaR tgaatcactt tgaagatatg gaataacagg aaatgggcaa
32881 aatgtatgac ccagcgtagg cctgtgaccc ctctcatggg gaggccccca gctaagggcc
32941 tcccctcccc tccccccagc agccctgggg gcctcctccg catccaccct acccaaggcc
33001 tgcgtgtgct ggggagaagc agctctcctt tcccaggttg cagRgggagg ggaagcccag
33061 ggacaatgtc cttgagtact gtctgagaaa ttgatcctgg aatctttaaa ccttgggggg
33121 aaatgttcaa agccgcagcc atctctgtgM ggagagaggc caagggctct cttgtttggg
33181 gaaacacatt gtaatgcgcc ttttgcttat gcaaagaYgc agccaagttt ctgttctgga
33241 atagacaatg aggaaggagc ggctctgcat ggcaatgtaa agtttgcctc actggtggca
33301 gagttccacc caggggatgg tgagccctgg gaggtggcct gcggctgctg ggcagaggtg
33361 actttgtcct ctgccaaggt gggggagggg tgcagaaagg ggggaaccgg tgcaggctcc
33421 ctactgggga ggcσtactgg cctgccagcc acagaggaga caggcagggg ccctggaaca
33481 gcagccaccc caaccttcag gaaagttccc atRtccttcg ctcagctgag ctttgggcca
33541 ccagaggcag cctgtggccc acctggcaaa accatgtcca ggagcaagcc aggcctgaaa
33601 agtctgtcag aggσctgggg gaggggggcc tgctgctctg tggcttctct gggaccccct
33661 gaaataagtg aggagaaggc tgttctctct gtgccccttc ggaggccagg cttggaccac
33721 caggatggag gcagagaaga gagtgcagcc aggagcaggg gacagaggtc tgctggcctc
33781 cgtggaggaa gagtttaggc attgcatggt gcctaaacgg ggctgccaga gcctgggctt
33841 atcatgagaa tcaacgttcc cattgcagat cttcttcacc ctcggctcct cagcagatgc
33901 ttcagaggga atgctagaag aaacgtgact cttgctcaaa atatcaaact accatgaaNc
33961 ggaaatggcc aggatcagaa ttactaggct cagttcatac atcaaaaagt gaggtggtca
34021 gagtcccctc cttcaatacc cagcgcagga acactctgcc caaggccacc ccctcactcc
34081 tcaggcgacg tctcctgtgc ctgtccacac tctgctgata cctctgcaga tgcctcaggg
34141 tggggacggg gctcctccac ttccaggcca gctcatcaat gcacagagcc cagcagggtc 34201 tcaagagatg tgctgcaccc ctcagtgtgg cactccagca ggcacgttga gaagacaggt
34261 cgcattacaa accttcccgg gtttgtacta acgacggcaa gaggctgccc ctccccctct
34321 cctgaatttg gggggttagc agagtgtggg ggggatattc ccactctgag gtcagatttc
34381 atgggtgcca gcatgggctc tgccacaatc ctgctgcgtg acttggggcc agttacttaa
34441 cctgtctggg cctcagtttc tttatctata aaatggagat aataaYagtc cctgtgtctc
34501 agggttgttt caggttgaag caacaatgaa aattatcacg tgcgtccatg tgaagagatc
34561 accaaacagg ctttgtgtga gcaataaagc tttttaatca cctgggtgca ggtgggctga
34621 gtccaaaaag agagtcagca aagggtggtg ggactaccat tcgttggtat aggtttggga
34681 tagacggtgg agttaggagc aatttttttt tttttttgag acggagtctc tctctgttgc
34741 ccaggttgga gtgcagtggc atgatctcag ctcactgcca gctccacctc ccaggttcat
34801 gccattctct tgcctcagcc tcccgagtag ctggggctac aggcgcccgc cagtgcgcct
34861 ggtttttttt tttttttttt tttttttttt agtagaggca gggtttcaca atgttagcca
34921 ggatggtctt gatctcctga cttcatgatc tgcccgcctc ggcctcccaa agtgctggga
34981 ttacaggcgt gagccaccgc gcccggccag gagcaatttt ttgtgggctg gggacggatt
35041 ttacaaagta cattctcaag ggcggaagaa tattacaaaa tatcttctta aggtaggggg
35101 ggacaatatt acaaagtatc ttcttaagga tgggggtggg gaagaatatt actaagtatc
35161 ttcttaagtt ggggggagag aatattacaa agtatcttct caagggtggg gagggtgtat
35221 catacaaagt agattcacaa gggcgggtcc ggcgggggcg ggtggcaata tcacaaagta
35281 cattacccca agggcggaga gggtgtattg ttcacaaatt caattgattg atcagctagg
35341 gtggggcagg aacagatcac aatggtggaa tgccatcagt taaggcagga actatctatt
35401 ttcacttctt ttgtggatct tcagttgttt caggccatct ggatgtatat gtgcaggtca
35461 caggggatat gatggcttag cttgggctca gaggcctgac attcctgtct tcttatatta
35521 ataagaaaaa caaaatgaaa tagtggtgaa gtgttggggt ggtgaaaatt tttgggggtg
35581 atatggagag ataatgggtg atgcttctca gggctgcttc gagcaggatt aggggcagca
35641 tggaaaccta gagtgggaga gattaagctg aaggaagatt ttggggtaac aggtgatatt
35701 atggggttgt tagaaggagc atttgtcgta tagaatgatt ggtgatggcc tggatgcagt
35761 ttggtatgaa ttgagaaact aaacggaaga cacagcgtcc gaataaaagg agaaaaacag
35821 gtattaaagg actaagaatt gggaggaccc aggacatcca attagagagt gcccaagggg
35881 gttcagcata attatttgct tggttggcga gtttttgggc tctatccttg agtttatgtt
35941 gtcatacacc aggccagact gatttaggta aaaacaacac ctaggtgatt caaaagcttt
36001 attgctcaca caaagcctgg tggtggtctc ttcacacgga catgσgtgac aaaagtgaaa
36061 tccccagcac ctagtacagg ctgaatgaaa ctgtcatcaa attacaggag ggtccaacag
36121 cccaagctgt ttccctggga ccccatgcac agaatggtcc acctgggctt cgcccttaca
36181 cccaccctgg ctctcctcct ggccatcacc atcgggagag gtctgagtga acagcttgca
36241 catgcccctg tgttttccag agctggaggg gctgctgtgc ccaggcacRt ccgcgagtgt
36301 gacccagccc tggagctctc cccgctggct gcgtcgcctt tggggaaaca acagccatgc
36361 caccacttag ggactgacct tcccacccgc tgaccggatg cctcatcaga aagggaaatg
36421 ctgcagaacg gggaaggacc agtgctgctg aggctgcagg acgcagaagg acacggccga
36481 ggcctcaggc cagagcccag tgtcccccag gggcctctcg gccactgcga gccactgaca
36541 gggaaaggcc gagaaaagtc agggattctR attcttgcta gcagtggctg caggacggcc
36601 ctgcctccct ggaactctgc tgagcttgtc ggctgtccct ggccacagag ccctgggggg
36661 ctcagtgagg agtttccttt caaagagggg ccctaagtgg ccagggctcg tgccaccccc
36721 ggccctggca tccccccaca cgcccgtctc agaggctgtg tggcccggcc catcccgtga
36781 ctgagctcgg tcacctgggt ccgtttgagc accaccatgt aatttgagaa caatgcattt
36841 ttattccccc acacatcata ttctgccgct gctctgtcac cagtgtgacc taaggaaaga
36901 gggaaggaaa atgccgctat gggaggagag agctgtggca tcaggggaca ggaacggtgt
36961 gggggagggg gcagcaagca gctgccgggg tggggggcgg gctgctgagc ccacaccagg
37021 cttggagccg gagccctatc cctaccgctg cccccgcctt agggtgagat gcagatagtc
37081 cccggggttc tgggctccac ttcccactga gatgagaccc tctgctgagg gtggaggcca
37141 acccacatgg tggccaagca ggtggttaga atggagaggg atctcatgtt aatgaatggg
37201 cctcaggcag cacatggatg cccctcgctc cagaaggggg tgtgtgggat gcagcagctc
37261 ctgctggcga gggccagggc gtgggtagct ggcactggct ggcagaggct gtagagtgga
37321 cacccatcaa ggcatagggc ttggactggg caggggtcca gcatgcctaa gtggcccagg
37381 cgtcagaccc gaccacctca gagcaaagct gaggaggact caggccagcc tccctactcc
37441 ccaggcatcc atgcatgatg aggaagaagg gagaggccct ggcagagcag gtatgaaccc
37501 ctcagagact gagaaggcat gacagagggc tgcaggccat caccttgcac tgtgcccctc
37561 gacctgggca ggggccccca aggcactcag agcgcagggc aagagtaagg tgaaggctgc
37621 aagaagggtc ctgcattaca agctcaσggc aagggtcgtc tgctgccagc gtatccctcc
37681 ctgaaagcgc agtcatgcag ggtgctttcc aacacccaga gcagatgttc cagcgcctct
37741 tgggcttggc gggaaacggc tttgcccttc tgtgcagcag gtcacaatcc ccctgcacca
37801 ccagagtctg tttatgtggc ttagctccct tgccagactc tggcagatgg aaagatagat
37861 gaaatcctgc ccaccgctac acaggaaacc cagaaccaaa ggaagagggg ccgaattatt
37921 ggaagcacaa gggtccgtga tcacttctgc tcaggatcag aagggccagc atgggcagcc
37981 cccaggccag gctccctgcc aggcgcgggt gggaggtctt gcaggctgca gccaggtttc
38041 cttcctcctg tctggctgca gggaagtttc ccttgctctg aagtttcctc actctgtgaa 38101 cattcccacg gggcacccta tgctgcctcg ggtgctgtcc catcctggta acttcctggc
38161 accatcgtga tctccagtcg ccttcgtttg ttagctgtct gtccgtctcc actaggcagg
38221 gactgttctg cattcttgct gatgcaWcct gggtgctcag tactcccgtg tttccccagg
38281 cttcaggacc aaggccaagc tcagccgcac gcgccttctc ccaccccagc gggctcccag
38341 ggtggccgag ggctggcacc tcttttgcac aaggggctcc tctgtgtgga atgatgccct
38401 cccactttcc acttgggaga caccaactct gtgaccaaaa ccagctcaag gatcacccca
38461 ctgtgactat ctccacKacc aggtggagac agctgaccgt ctcctttggc tgccaagRcc
38521 ctgtcctcRc tgtgccaagg caagcaggtg gcccccatga gaaaaaagct tgtccaggac
38581 gggagctggc tggggctctt cccagacatc atgggccgag tgaacaactg ctcgcctcgc
38641 tggtcggctc tgatcttctc cgcctaYgcc gagtacttcc ccgcgtgcga tatctttccc
38701 ttcccacacc ctgcgagtga gtgttatccc cgctgtgcca gtgaggaagc cgaggcacag
38761 agagattgag aggctcacat aagtgggcat gggagtcagt acagaggctc tgaggagcaa
38821 tttggcaaac ctgctgcaac tagaaactgt atcccgggac ctggccattc agacgtcagc
38881 atggacgatg gagacacagc ctctgtcata gaagcgaagg cataaggaca cccagccacg
38941 aggagttcca cacccacaga tagagttcat ttttatggga gtctctgaga tcacagtcgc
39001 tttatgggaa ttcatttagt cacttattca ttcaaaagag atttactgag cacctactac
39061 gtgccaggcc ttttccaggt actcagtgaa aaatcaggtg ggcagaccct ctctgggtcc
39121 gatacaaagt cacctttgtg ggagtcccta accctgctga gacacaccac caaggagacc
39181 cctggactgg ggaggaagac ccaggattgc ttgactgcaa ctcagctcca ggggcagcct
39241 gggaggggcc tcagggagtg agagcccacg ccaggtcagc ccgacagccc ggcgtggcac
39301 atcatcgcct ctgttcttgt ggttcagctg tcacctcctt gctggagcct gcacaagaca
39361 agctccgagg ctgcctcaag ctgtcatccg ggtgtgtgga tggctggccc tcctcgtcca
39421 cagggactct aactcccatt ctgacaacca tcagttcccc gcgggaggcc aaggacagga
39481 tgctgggagg cttccacatc agctatcagg aggtctgcgg aggagggagg agggaggagg
39541 tggggagatg tccactggtg gggagggtgc tgcacatttc aggaggaagc agaggtgaga
39601 tccacccaca agacccctgt tcgagtgttc cccacctgct caccatcact ggtctgtcgg
39661 cctccccagc cctgctggaa catgtgctcc ctgcggtctg gatcccgtgc tcaccacgac
39721 atccccagca cctagggctg ctctatccgg gtgcactaag ggagtgagtg ggcaggcggg
39781 Ygggcctcag aacaggagga cacagtagat ctatgcagaa gccaaggcaa agcaagaggc
39841 agagcggatg gcctgYgggg agaggcgggt gtggccaggg gactccaaat gctgtgggga
39901 ggtcagtgag gcctgagatg agaaccYgcg gagcatgcta ggggatttgg gagctctcga
39961 tcttcaggcc agacagtagg ggaggaccag cacaggggcc accttcccac aggtatgtga
40021 ctccatctgc cgtgctctgg ccatgtctct ctcagtctca gtgacctgat gcaggcaagg
40081 gaacctcaca gggccactgg ggcaaggtag tgaggtcaca ggtgtgcctc cttgcacagg
40141 gccagcacgt gcaaaaccag caaatgtgag ttcccctcct caggtgggga ggggtgtttc
40201 caaggataga aagcataagc cccaaacctc ctaagagaga ggagtctatc tttgtagacc
40261 acaaatcaac ctcgctcccg ctctccaagc cccacaagct ccagcagggc ccaatctgcg
40321 cactgcgatt cacgatgcgg ccaggccttt gcgcgcgctg tgccaccacc aggagtcctc
40381 attagaggca actgcggtgg cccttgtccg aggagccttc cctgaccagc cgccccaggc
40441 acccttccct gatgaaccaa ggtgtaatca cgtgtcctga tcccgctccc catactcctg
40501 tgctcYgagc tcccccagtg cagggatgcg gaggccagga gtccagggag tgccgaacat
40561 gactgaggac agctcccaat cccagcatgc tcctcccaca cccgtgctct actgagcact
40621 ttcctggtgt tcaactcgag tggtgctccc aacagccccg ggagttggca ctgaccagca
40681 cagggcgcag caggacaggc agtcgcctcc ttccttctag gctggaaaga acactcaggc
40741 cacccacaca ccagacttgt cctgcagccg tgttctgctt cacctgtgca gtgtggcttc
40801 ttaatttcaa tctgtggccc acattgaaaa ataattagat ttcccaaaaa aagtagattt
40861 ccagcttctc atggaagagc gagctggcag cagtggtctg cttattccta cagaaacaca
40921 agcgagtgga accacgagga gctctgcagg ggggcgtggc ctctccggtc gcccgagtcc
40981 ccaccactcc caacagcctt cagccacctg ggcccctcgg gσctggctac tgtgagcacg
41041 tgagggcact gccctcttct gagccttgcg tgcagcctcg cacacaccac tggccctcat
41101 ggctgtgtct cctggtggca cacagggcca ggctgtaagg ccagcgggac aagcgtgagg
41161 aacagaaaca gtgccagcaa cacccccagg gccacagcac cactagcaga ccctgaaccc
41221 cgcttgcctc cccccactta agggacccgt gtttcgtgtc cagtttcaga gatgttcttc
41281 tctttcccag gaaccagagc cagcgactcg tgaactatga cttggggcga cgccttccgc
41341 ctggctggtt tgcatctctg cggccagttt acgagatttc caccacgacc agctgaaaac
41401 actcctgtcc gaccactgcc ttccccaccg ccaccatgcg gtctcagcac tcgtgaaagt
41461 tggtgagaaa ttgagcccat atgccttcgg attgtttgca aaccctggca aggctctggt
41521 aagtccaggc caatttctgg attaaattag aaatgaaaag aggaaaaata tctgaatcct
41581 ggcatagaga gaaatcattc attcaaaaaa aacggtcgta gaacatactg tacagagaat
41641 gttctcgtgc tgggaggggt caaaggttat agccgcgact gaaggcgcag aagatccttg
41701 gattccacgt tctccatagg cctaggagcg tgtctgccct cagcagaaga gatgctttgg
41761 gggctcaggc attctcccag aacataagca gttaacacag ctgggagaga ctattctgca
41821 tgcccggaaa cctgctcctc ctgctctgcc gttctacagc ggttaagaSc agttcattct
41881 atcctttaaa aagaatcccc gaagtagcct caccggtcct ttgagctgat aaggctagtg
41941 tgggggtggg ctggggtctg agcagcccac tgtgctcagt acttccctaa tacgtacacc 42001 cacgtgcact gatgtagtga aaggcacatg ctcactttgg aggcctgggg ccatcacagc
42061 tcaaggcagg cactaagcaa gtacatttct gcac-agcctg gtagcaaaaa ttcctttagc
42121 acctcatagt gaatgttctc agctttgtgg gccatatggt ttctgttgca actacccaac
42181 ccactgttgt agcacaaaaa tggccacagg caattcataa atcaataggc gtggctgtgt
42241 tccaataaaa ctttatttac aaaaacaggt gaagggccag gtggccctgg ggccagagtt
42301 tgccaacaca gctttagaat ctccagttta ccttgacaaa ttcacgtgaa ttttgctttc
42361 atgcaagtaa tacgtccaaa tttactttaa tgtaaaactg atgttttaaa atgcttacca
42421 tccaaaaaag gggccacttc agggggagat gYcttacatc tgtctggtgg cctctggcag
42481 gcctgagagt acgtgttcct ggtagcaata ggttgagcgc tggccttgct gcaggctggg
42541 tatcacccac tgcaatggtc tgcctcctgt ctacaaggag tgcggtggga ccaggggctc
42601 acaaagacag ttcaaggtct ttgtagatcc tgatatttaa gcaacacatt gaggccttag
42661 gcttctcggg aagagtagga ttgaaattag cgctttagtg aaatgcttga agccacaaag
42721 gaagcttcag ccttgggccc aagctttata ttt tgaag tcttggcaca gatagatttt
42781 acttttaaaa atgtatctgt agccaggcgt ggtggctcgt gcctgtgatc ccagctactc
42841 aggaagctga gacagcagga tcacttaagc ccaggtgatt gagtccacca tgcagcatag
42901 catgaacctg tctctaaaac aaatctttaa aaaatgagtc aggcatggtg gtgtgtgcct
42961 gtagtcccag ctgcttggga ggctgaagtt tgaggctgca gtgagctatg attgcagcac
43021 tacgctccag cctgggtgac tgagtgagac cctgtctcaa aaaagaaaaa aatgcatata
43081 taaacatatt acttccacaa cggctctgat cttccaaggc attcatccct gcctcccatt
43141 tacctgagcc tgcagaagag tccctgtctg tacctgggga cgaaacttga ggtgccacac
43201 acatctgagc tgcctcctag catggcagcc tcgcctgtca ggcccaagcc cactctttag
43261 gggtgcccag gcccacacac atggccacag catctggttt gtgagcagag actagcccag
43321 gcgctggcag agcaagtttt tgaaaatgtg agaaatacca aagccccagg gtcagtatca
43381 ggcatgttca gcaatgtcac ctgtgtccca gcctggcagc acccagtact tcagggagta
43441 tgtttcccaa gcaggaaagg tcaaacatga cagtggtctc ccaatgccct cgggggcggg
43501 gggcgggcct gggcagagga gagcccctta tcct cccggc tgggcccagg ggaggcagca
43561 acgcaaggtg gaggctgcag gctgagccag agtagaaagc tgggaggagc aggagcagaa
43621 tgaaggcaga gggaatagaa gtcactctgc cagtgacggg gctggggggc cagcaaagct
43681 ggatgggcca cacatctgcc cacggctctc actccatcct cctagcctca cagtgcttgg
43741 aagggagacc cctctgccct tagacggggg aatgtgggca tccccaaggg gcctcagcat
43801 ctctgaccag gctaagggcc gctgagcctc aggagaccag actcatccca gggttgccag
43861 cagccaggag ggctacagct gcgtgtgctc aaactccagt gtaggccggg agcagtggct
43921 catgcctgtg atcccagcac tttgggaggc tgaggcgggt ggatcacctg aggtcaagag
43981 ttctagacca gcctggccaa catggtgaaa ccccgtctct actaaaaata taaaaattag
44041 ccaggcatgg cggcacgtgc cagtagtccc aggtacttgg gaggctgagg caggagaatt
44101 gcttgaacct gagaggtggc ggttgcagtg agccgagatc atgccattgc actccagccc
44161 gggcgacaga gcaagactct atctcaagga aaaaaaaaaa aaaacaaaac tcactgcaga
44221 gagcctctgt ggacaagggc ccgccccctg cctgccacag gctcagcaca cacccagtgc
44281 cctcttagca cggctggctt cgcctgggcc tcagaggtgt gtggacatgc ccaagcagag
44341 gctggggaaa ggccacagag aacgggagtc tgaggtggca tccagggggc acatgcaggg
44401 cagcaggtgt tccctcaggc tatggggtct gagσgcaggg ctcaggtttc tgggctcgcc
44461 ctagggacag gctgacttca tagatgacca gggσctatcc tcagaaggcc ccgaccttgg
44521 ggcttgaccc tctgcagctc tgtcttgaag ttc tcgtca tctcaccctt gcatgtgtgt
44581 tttgtaagtg aaggctcctg gggcaatgca gcatggtccc atctccccag gacaggcttt
44641 cagctgcccc cagcaggggc aggatcaggc atgtattccc cacggcatct cagggcaggc
44701 gtggtggtgg ccatcccgcc cacggctggc aggaaagggg catgtctggt ggatggctgg
44761 ccagagcccg tgtttcggca gaggtgaRcc tcccgtgagt gacacctgca tagagatggg
44821 attggccgtg gccatacgct ctgggctgga gcagrtgcacc agtaggaagg gggcgtgcct
44881 ggctctactt ccccagacgc cctggccagg gcacagccaa tgtgttcttc caggggtggc
44941 aggaagctct cagaccccag tgggtgtgcc cttcctgctg ggggtgcact cactctgcta
45001 ggaccccgta cctgaggagc ctcccctcgg caggattcca ctctgtgaaa tcctctcttc
45061 ttcctcccag cctccctgag tctggctgtg cctgtcataa acttctggtc agcctgaggc
45121 acccatcagg gatcagccac aaaatacaca tttgrtttaat ttcagtgacc ccacatagaa
45181 gctaaatgct ctaatatttg catttaaaat agccatcgca caatttaaag atgaataaga
45241 aattcatgct aataattcaa ggttccaatt tttgjttcact tagaacaata ttaaaaagca
45301 aataaaaaga acagcgagtt gagagacaga gagacagaga ctaaggaaga aaggaagtgg
45361 cttaatagtc cctttgtatg gcaccttcct ctgctctttg aacaagcgat cccacatttt
45421 cattgtgcgt tggggcctgg gagttactac tggctctgcc tttaggccag tgttccccac
45481 tggtaatatc ctgacgagtt ttgcagcagc cagatattga ggggaaataa gaatgcattg
45541 catgtaatac attggctcct ttgaattctc tatctccccg ccacaccttt ctttcctttt
45601 tttttttttt ttttttttga gagagaatct cactctgtcg cccagactgg agtgcagtgg
45661 cgtcacctca gctcaccgca acctccgcct cccaggttca agccattctc ctgcctcagc
45721 ctcccgagta gctgggatta caggcacgtg ccaccacact cggcttattt ttgtattttt
45781 agtagagatg aggttttgtc atgttggcca ggctcgtctc gaactcttga cctcaagtga
45841 tccgcccgcc ttggcctccc aaagtcctag gattacaggt gtgagccact gcactaagcc 45901 tatctttcct cttactttgg gagaaattca ggtggagggc tgctatggct aaacccaaga
45961 acagtcagcg gttggtgagg aactggagct tgggaagtac agctgccaag tagggcagaa
46021 actcagaaga ttaacttctg gggagggcag gaggcatcMa acacatcacc caagggagaa
46081 gcttttcccc tgggaaggga aagactgcag gatctttccc tgtggtcaca cacacaaaaa
46141 tgtaggacat caaaaactat cccaggcgga ataaaacaaa agcjtcaacaa caggactggg
46201 ggaaatattt cccacacatg tgacagacaa aaagtttatc tacttaagta cacagactct
46261 tcagatgaat aaaacacccc caaatcccag cagaatcaag ggcatgaata ggccaagcaa
46321 aaaaataaaa taatctctgt ttacaaatac acgtatattt ttaaatgcag gctcattaac
46381 atcaaggaaa taacaactta caacaaaaaa acttatctcc gttgtaatta aattaccact
46441 gctcaaaagg actcagtggt gtgaggaggt ggggagacag tcatttgctc aatgaagcgg
46501 gaatagatga aaccataaca gagaacattc cagtgtagaa agcttaaaaa atgggcatat
46561 ctgttggcca gagacttcgc tttcagcaac tcagcttaag gaaataagta agcacgagcg
46621 atagattcaa ctctatgaac gtgatacagt tagtggcatg tctgacctct aatggagaaa
46681 taagttttgc tatgtgaata tgtcatataa ataataagtt agcjtaaaaag tgtgtgacag
46741 tcatatggtg cgatgttatg caatcattaa aacaacgtag tagacaatta actgctggga
46801 gaagacattc acatacctac aggaatttat gctaatttta catagYaaaa aaaatgtccc
46861 ggcacggtgg ctcacgcctg taatcccagc actttggaag gccaaggtgg gtggtcacct
46921 gaggtcagga gttcaagacc agcctggcca acatggtgaa accactgtct ttactaaaaa
46981 tacaaaaaaa aaaaaaaaaa aaaattagac ggccgtggtg gtgcatgcct gtaatcccag
47041 ctactcagga ggctgaggca ggagaatcgt ttgaactcgg gaggaagagg ttgcagtgag
47101 ccaagatcac accactgtac tccagcctgg gcgacagagt gagactctgt ctcacaataa
47161 ataaataaat aaaataaatc atctgtgtta aatatggact atttcaataa accaaaaaac
47221 atgcttttct agatgtaagg aggaagataa gaaaactgga cccagcaggg gctgctggag
47281 tgggcaggtg ggtggttgcc taaaccaaag agcccctttc tgtgcccagg tggcctcatg
47341 aagtgctcca tttccaagcc gcttcccttc tggcaagtct gagatgaaaa gggcagcttc
47401 atctttccca tagaaaaggg aatatcacgt cttgtcttta ac-atagacag gaagcagccc
47461 ctccagtgat ttccactgct cccggagcca caggcggctc ccctccacct ctggaagact
47521 gcggcggccg gccttgccgg ccccgacttc ccctacctgt gccccctgct tgacaggcca
47581 ggctgcctcc attcttccag ccggccccat tcctgcctca gggccttggc gccgcctgcc
47641 ccctccccca aacctggaac aggcgatccc tatcctacct cttcccacat ccttccgttg
47701 tcgtgagcct cWgctcccgt gatatctcca gtgcaccagc ccctgagctg tagaaagtgg
47761 cctgccttcc cctacccttc ttccttctcc atctcctaac tattttattt ctttcattgc
47821 atttgtcatt atttgaaatg atcctgtttg tttttcactt cagtatcgtc tgtgcctccc
47881 ttcccagaat gcaaggtagc agggttacgt cctgtcatgc tceacagctgc accccttgcc
47941 tgacatataa tagacgcccc ataaacaccg gcccccgtat gaεacggcagc caggggcacc
48001 agacagagga ggatggctat gccgagaatc caccccatct cagjcagctga acacaataca
48061 ccgcacaccg tgtttcctta ctcacaccat ggcgcggggt gggtcgggag ggcccgagcc
48121 tatgttgcag ctgtacctac tgggacacat ggcttccaag gtttccgtgg caggggagac
48181 agagatggag gggactccaa gctcttacca gccttggtcc acεaggtgacc caggtcactt
48241 cctttcacac aggccactag gcaaaactgg ccatgcagct cceacaccagc tacaagggag
48301 actggggagg ggagcacagg ggtgatcgat gaggctgaac tgcctgtgcc acccctggac
48361 cccatatccc agcccaggct ctgccacaaa gagatcccaa agggagctct gcaggcagaa
48421 gtcaccccaa atgatgaggg aaactgaggc agtgcagggc tgccagggtg gagctgtgcc
48481 tgcactcagc ctgccaccac ctcacctcct cctcagagcc tgcattccct gggtccccac
48541 catcagggcc cccaccagct cctcctccca gggctcgacg gcctttccca gggcacaggc
48601 tgtgccacca ttctctgcat ccagttcagt gggcagctca ttgcccaggg ctggccccca
48661 gaccccgggc tctggatgtg ccgttgccca gccccacctg ctctacagct ccagacaaac
48721 acctcactgg gagcccagtc ccagccggct gctgccacgt ctgtccttcc atgcttttgc
48781 tttcgctcca gccacRggga gccctgtgac cagctgggac ttεacaagagg agtgtgacaa
48841 gccactggcc aggccttaga gggccacttg gggttgtggt tcgaggcccc catagcaccc
48901 aagttcagag acagggcacg gtaggcagat cctctgtgca caggcccaac cctgccctgt
48961 tcagcacagc agctgccagc cacactgcgg cttccatcca ggtgaaaatt aatccaaaca
49021 aagtactctt cggggtggct accgtaaaaa agaaaaaaaa gacaagagtt ggtgacaatt
49081 tggagagact agaatccctg tacactgttg gtggggggca aa_atggcaca gccactgtgg
49141 gaaacagcgt ggaaactcct caaaaaatta aagaaagaat taccctgtgt cccgcaattc
49201 tacttatggg catatagtca agagaacgga aaacagagtc tggaacaccc acgttcacgg
49261 cagcactatt cacagtagcc catgaggggg ccaccggagt gcccatggat ggctggataa
49321 acaaaatgtg gccgatccac ccacacacgg gatactggtc ctccctgaaa aggaaggaca
49381 ttcttacaca tgctgcaatg tggatggccc cgaggatgtc atgctaagtg aaataagcca
49441 Sacacaaaag gacaattatt gtttgatcca cttatgcgag gtsacccagag tagtcaaatt
49501 ctcagaaaca gaaagtggag tggtgggtgc caggagtcgg ggggagggga ggaaagggct
49561 gaaactcaat gggcacagtt tcaattttac aagatgaaga gWtctgtgga cggtggtggc
49621 gatggtggcc cagccacatg aatgtgctta cgccaccgaa tcgcacgctt aaaaatggtg
49681 aagacggtga cttatgttct gtatatttca ccgcaattaa aa-Ktttttaa attaaaattc
49741 tcttggaaca aataagaagt taaattaaaa attcagttct tcaaggacac cagccacact 49801 tcaagtgctc cagagccccg gtggctactg ccccagaaag ggcgagacga gcatctcccc
49861 agcaccgcgg gaagctctgt cgcacagcag ggctctggaa ggtcaccctt tc tcagaagc
49921 tcccacttgc tcaatgcccc tcctccccaa gaccaccaaa gggtccgaca tagcttagat
49981 ctgtcctcag gactctccgg gcatgcagag gctctcagtg aggacgcagg g attcatcg
50041 tcagggcaaY gccatgctcc aggcacggcc gcgccttatc tccctcgccc ac ctgcgct
50101 cttgcagtgg gagctggggc tcagatcaga ggcagagacc ccccgctgac cc tccgccgc
50161 cggtctccca Ygccccggga ctctctgcca cgccccgccg cctctgcagg ac acccccac
50221 tgtgcccatg acaagcacac tgtcaacacg tttgctgaat gaatcagtgc tcacttctgt
50281 gcaacagggg acaacagaca cggcccaaat actttctcaa cttctgagac ttgtctccta
50341 aaacggtttc tctgttgtga taaaactcat ctcaatttaa gaatttttaa at ttctcatg
50401 cttttctaga aacgaacctt cccattattc aaaatagggg gtacggctgg at cactaggg
50461 tttgaataaa gttggaYggc aaaagtgaga gaacgttcta gacatcctcc aaccagctgt
50521 tgtgacagag agaccctggg caccaggaga aaggttgatc tgcctctgcc agcctcatga
50581 aggactcacc acgggcccca catttggtca gcgcccttgg tgggctatca gaagtgaccc
50641 ctcctggact gtcactaaac agtgccactg tcatgataac aaaaccacat tt tatgtgga
50701 aactgaaaac gtgttcaccc tactgagaga ctgaaaagca cattcactga cattatctca
50761 tgtaatcaca tcaaccccca cgatgaaaac actggcccat tttacagatg agraaaacYaa
50821 ggctcagagg acRggagcag cgttcccaac gacgcgcctg gaaaaggcga ggrcctggagt
50881 YRccatcgga ctgtaattcc aagcccagtc ctttccccgc tgggttggaa gcrcgacataa
50941 tgctagggga agaactcata ttgtgaaggc agccaagatt ttatacctgc ca-gtctcaca
51001 gacctagcat gaggacttcc caagataatt tagcatggca agtgcccagc atgggcccgg
51061 cacagtcaca tagtaggggc tcgataatgt agccattatg gttttattgt ta-ttattatt
51121 attattatta ttattatttt tgagacggag tctcgctctg tcactgaggc ta-gagtgcag
51181 tggtgcgatc tcagctcact gcaagctccg cctcccaggt tcacgccatt ct cctgcctc
51241 agcctcctga gtagctggga ctacaggcgc ccgccaccac gcccggctaa ttttttgtat
51301 ttttagtaga gacggggttt caccgtggtc tcgatctcct gacctcgtga tσcgcccacc
51361 tcggcctccc aaagtgctgg gattaYaggc gtgagccacc gcacccggcc gt tattatga
51421 ttattgcatt aaaggtacgt ttcaaaaata agatgagggt aagtgtgaca acgctctccc
51481 aaataaaacg aattctgccg atgcagcgga cttcggcccc ctgtacggat aagRctgggc
51541 tccagagggc tagctgactc acccaagacc ggtcaagagg aaagtgagca tgaaggtggt
51601 gtctctgtcc agtgttcagc tcactcacat cccctcctgc ccctgaggta tcttttcacc
51661 agggccctgg ggactctgac ccatgtgtca gcttggctcc tggaggggct cacccctggt
51721 ccgaaaagca gagctgggca gcagatcctg agcagacctg cacaccctgc tgrcctgcctc
51781 tagcccggcc ccagaggacc tcattcatcc acaggtgtgg acacgcagca cgjgggttcta
51841 gaacttccca cctgcccggc ttccacacca cctccagccc tccctaagcc ccggcttcct
51901 cccacaaata cccccctgcc cctagggccc cactggcagc atctcacatt ccaggccgtg
51961 ccctggtcct ccttctcacc cccttctttt ccctgcagga ctcagccaag ccagtctgct
52021 cccctgggag cctgcatttt gaagactgga cgcccctcat ccccacagtg gctctgacca
52081 catgaggcag agagaggaaa ggtctgcaca gcctccaccc acacacggtt cagcatcctg
52141 gcacctcctg cttaggttgt tgggggtatg gaatgagggg gaggtggttc tttaatctct
52201 tagtgttagg cagaccatgg gcaggtgccc agaagacgaa ggtggcacat agacacccct
52261 ttcaatagcc cagactcaca gggagaaagg aattccctcc ccaattcctc ccactgYgag
52321 ctttaaggag gggccctggg ttggtgtctg gccctcgctc taatgcaYgt gaatctctac
52381 tttaaacaga aaaggggctt ctgtttggag cgagaagaag gcagggctat ccagctgggg
52441 ctgaataacg tcactttatg tcttactatt atattagctt ttcaggtaaa ataaggttgc
52501 ctttttaaat gattttagtt ttaaaagtgg caaacatcaa gaaaacatat ttttcaaatg
52561 acgggacatt gaatgacatt gtcattcaaa cgactggagt ttgcacaaac ccgccttagc
52621 ctgtgaagag cctcaccaag ttaccatcac ccacgatgtg cagacgagag a-actgaggtc
52681 agggatggtc aacttgtctc acctggggac ccagcaagcc tccctgagac tgtgtcactc
52741 acctccggct aacaaggaaa tcggcagagc ctcaggggac ctggcccagc tgggcctctc
52801 tggcctgccc agcccctggt tgaccctccc cgccccaccc tgccccctca gccaccccac
52861 tcacaatgtt catgagtgtc agcaggtact tctgtacgtg ctccttcccg tggaactgca
52921 ccacagagtc atccacgccc agcaggacct cgatgttgta gtcatcgtcY gcagcatgcc
52981 tgcgtgccct ccgcctcgag ctgttggcgt gctcctctag gaYgcccagg gcgcggctga
53041 ggctgtccag gctgtccagg gaggcccctg caaggagagg acaccgtctt cεagcggcagg
53101 gcaaacccac ccggacacaa acctaccagg cgccagcttg gccatcctct catttaaaac
53161 tcatagcacc ctgaaccgag ggtattattc cattttacag aggaaagcga ggtgcagagg
53221 aagatggcag agacttgcca agctgtctca gacacagcag ggcccagaca ggcacctctg
53281 tgacttccag gaccgctcgt tccccagccc ctggtggcaa ccccagccac agcaggggcc
53341 acagtggcct ccacaYgatg gatcagacct gctgagactg tgagagaccc agcccagcat
53401 caccgtctgc cttatggagc ccagggctgg cattcagcca tggagaggtc gggaacctca
53461 gcccgcactg cctgacgctg gagtgggcag agccacccct tgcccacact gcccgatgct
53521 ggagtgggta gagccacctc ttctcccccg aagggctgcc aggtgccaaa ggactggtgt
53581 cccaggtgtc atcgccagct gttatgactg gggaaaccga ggcccatcct gggctgtgca
53641 tgttccccag tgtctccttg ggcccctccc agaactttct gctaagtcct ccactgaagc 53701 gaggccccac atctctgggc caggtcccgg gccccctccc caggtgaacg gtaccgcctc
53761 tggcctgatt gaattgtgca gagaccaaga tgaacccctc tgtggcagct ccgctgcagt
53821 cggccctggg caggcactga cctcctgccc ccagggtgtg cccctggcca cttggggctg
53881 cMatcctggg gagtctgccc cggatatcgt ccctgccttc tgtgcagtgc tgtctctgct
53941 gtgttctgtg tcctgcgggc ctggagacca ccctggacca ggcttcagtt cccagccctc
54001 cactgcccgt ctgaaggcca cagcaaggct ggccaggctg acctgcagca tcgatggcag
54061 ccccagacca cactgcccac cgccccccaa gccccagtgt cctggaagcc ccctttccct
54121 tgcactggtc tctgtgtcta agccaggtcc cagccccagg gtctccatgg cεattccccag
54181 gcaggtcctc agagactcct ggcccgggac agacccaggg ctgcaggtca tcgtgacatc
54241 actgacccac agggcggtgg ccaggccccg aggcccctgc agctgaggga gεaccagcgtc
54301 cctgctgcac cacctctcta caaagagtct tccagaacaa cacttttcac ccccaacgcc
54361 tctctcctgc tgcctcttcc aggcagggac aggcactccc tccctgtgag ggtggcccag
54421 gacaggccct ggaggcagaa caaggcccct gcaggcggca cggccactcg gεacagtgagg
54481 cagcctggta ccaggccctc atcccggcac acgcttcctc acccagtgct gεacagcaggc
54541 cactcggtgg acRtggccat ttccgtttta cagatgggga gacccatggc atcccagcat
54601 ggccgactct cggccagaag ctctctcctt gcaccctgca gcctggctca gsacaagacag
54661 actgaacatg aagtttcagg cacaaacctg cagcccggct gtgggcaaga ccaagacaga
54721 cagtggaggt gcgaggcgga gggtgagggc tgggaaagag aagaggagta agtggggcca
54781 gggctgagca gctgctgggg ttccagtacc ttcgggggtc cttgtgccac ccccagctcc
54841 acagttctgt gtcccctcgg cgcacacaca catgcacaca cacacacatg cacacacatg
54901 tacacacaca caagcacaca catgcacaca catgtacaca cacaggcaca cacacatgca
54961 tgtacacagc aaggactttc cagggccact ccagggacag gggtggggcc ggcaggcctg
55021 cgggcagggc tgtggggagc cgagcagtcc acttagctgc ctggatgact cagggccatc
55081 catgccgttc ccagaggaag cgccagcaac tcaagcctga caggggggtt gεaggaatcgc
55141 cactctattt ttgtacattt atttctttgc atttccaacg aacagagaca gctcaccttc
55201 agaatcacct tgggaaggag agtgatggca atttccatag gaaaactctt cctccctggg
55261 gaacaggccg ggcgttaccc tctgcccttg tcaaactagg ggtcacacac gggcggtgcc
55321 ctcggcaaaa ccagaccaca gaggcactcg ttgaggtcac gtggtgccat ctggttgata
55381 gtatttgaaa actgggagat ttcatgtttt aaaaatctag aacatccagc ttctcttgag
55441 gaattaagag atggggccac cccaggggta gcccKggtct gtgaattgag gggccacacc
55501 tggagacaaa acacacaggg cttggctcaY caggccacct gcctgccact gtcaatgtca
55561 ttctggcacc agaaggtatc acagtatgtc ctcctggccc taaccccaga gtccccatgc
55621 agggacccct ccagacattc cccgtaggag ggcatgggtg ccgcatcggg acagagctgg
55681 gctggggcac Rtcttgaggc tgcttctgcc gagcaggcag agtttttaac taaactgtgt
55741 gttgcaagcc cattaaaaac agcaaaggtt tctaaagatt tagaatctga atttcacctg
55801 aaatggaatt attattgttg ccatcattat tttaatcgtg ataatttKgg ggtgaaattt
55861 ggaaattatg ttctagagSa tccctccacc caggaccagt gcctagagag acggcccaag
55921 gcccaaaggc aaagtgggtg aggagaggaa gacaggggcc tgggccacct ggcaggtgac
55981 agccacgccc tgcgtctggc ccctggaagc ctcagtggtg ctcaggctgg acaggacaag
56041 gggagaagcc ctaagagcag ggggatctgc aatgccctca gacctggggc aacaggagct
56101 ctggcccagc ccccctcctg tcctcctctg tcccaacaag acccggcagt caggctgaag
56161 ccccagcttg tcaatcacga gtgccacctc agttttcccc acaataagat tgaccctgac
56221 cctgtcaatc acgagtgcca cctcagtttt tcccacattg ggcttaaccc aggccatgaa
56281 gagactctga ccacatgctg gcccttgcag acctgYtccc caaatagagc cttgctatag
56341 ggagctctgg ccagtgggcc tggcgtggtc ctgagtcgtc ttcctagtga tccctttgaa
56401 gtcaaccttg gccttgggcc tgcccacctg cactggttgc ctacctggtc taacagcccc
56461 tgttccactt ggtccctcca aggcagaaga gggctatttg ctgctctccc ctcctcccct
56521 gggagctccc tgtgtagccc agccctgctg agctgtggtg actgggagct cacacagcct
56581 ctgctgtatc cctcggcact caccccgcct ggatgagtga tcagcgcacc catctcctgc
56641 agaggcagga ggatgacact gcccttggcc ttcctttcct ctgtgtgcag ccttccccac
56701 aagaaggcac tgggccccct gggggtgctg attgaccaag ccccagaagt catacccagg
56761 tgggctgcag ctaccctgaa gggaggtgtc tgtggcagga tcccatcttt taaataggta
56821 acacagagct ttcgagttcc tggcattccc tgtgctcagg gccccttttg gatggcagct
56881 ggagatctct ttgctcacat cgtggccaaa Kaatgacact gtgggaagca c tccagagcc
56941 atcctgtttt agagtctcta gaatggaaca aaaagactct atcgaagagt c atcaataa
57001 acagggagag gatggaatga ggggaggcag cagttctgtc cagggaattc catcagggga
57061 acgggtgggt cacagtagcc acgggctcat ccacagtgcc acagtgcaca gggcacgtgg
57121 gcaagggctg caactgccag catcctaggc acaccccgag tctccaggca ggggtgtgtg
57181 cacagccctt cacagtggca gctccatacc cccagcagcc atccaatccc c tcgccaagg
57241 tggaggcgtg tcaccatcag catatcgtcc tatttcagca tcagggaaac a accaagga
57301 gcaggaaaat tacatgactY ggacaagcca caccaccaga gaggaggagt gggcacgcgc
57361 ccaggcctct gagtccaacg ttgtccacat Rcccggagcc cttctgtact t caccagcac
57421 tgaggggtga tttgcgRgaa tgagaattgt agaaacaagt atgattagac t agagaaSag
57481 aaaacctggg actgagtctR caacctcggg agcatcgtgg gatggtgcgg gctctgaggg
57541 tgggtacagt gggcaggtgt gggatctgtg ggcaggtgca gtgggcaggc acgggctctg 57601 tgggcaggtg tgggctctga aggcaggtgc agtgagcagg cgtgggccct gaaggcaggt
57661 gcagtgagca ggtgtgggcc ctgagggtgg gttcagtggg cacgtgtggg ccctgagggc
57721 gggtgcagtg ggcaggcatg ggctctgtgg gcaggtgtgg gctctgaagg caggtgcagt
57781 gggcaggcgt gggccctgag ggtgggttca gtgggcacgt gtgggccetg agggcgggtg
57841 cagtgggcag gcacgggctt tgtgggcagg tgtgggctcc gaaggcaggt gcagtgagca
57901 ggcgtgggtc ctgagggcag gtgcagtggg caggcgtggg ccctgagggt gggttcagtg
57961 ggcaggtgtg ggccctgagg gcgggtgcag tgggcaggtg tgggccctga gggcgggtgc
58021 agtgggcagg tgtgggccct gagggcgggt gcagtgggca ggtgtgggcc ctgagggcgg
58081 gtgcagtggg caggtgtggg cctgagggcg ggtgcagtgg gcaggtgtgg gctgagggca
58141 agtgcagtgg gcaggtgtgg gctctgaggt caggcagggg ctttgcagtg ctaagggtgg
58201 ctgggtgttc gctgtcccct gtgcgaagct cagtcctatg ccttttctgg gctggcctct
58261 tcacctgcga tgcccttttt gctgctgccg ctgtgctggc caaatttagg ccccctgaaa
58321 gacccagaag gaagggagcc cgctgcctcc catgggactc agagctcttg aaagacagga
58381 gcatgttctg cccccatctg cctcctgcac agccacactg cgtgccacta ggggacgaca
58441 gggacagggg ccggggcagg gatgcttaaa acctgaggac cacactgttc agtgacacgg
58501 ccgactgctg tcccctctcc atgggatggc cgccccctca ttgctctctt ccttcaggtg
58561 tctgctgaaa tgtcagctcc taagggagaa ctttccttat ttcatcccaa attgaaatca
58621 gccctcccct gatttctccc gacagcaccc cgtgctcttc cttcctgtga cactccactg
58681 caggcaggtc ttgtctcatt tgtgaatttg cctgggcatt aactgacttt ccctctcaga
58741 tagagaaccc tgggggatgg agaccatggg gtctggtgtg cctcagtgtc cccagtgccc
58801 cacaggtaac cgcagggctg tgaggggcct ggagccatgg cagagaggtg ctctgggaac
58861 agagggccca gcagaggcga gctgggggcc tctggggagt tgggaactgg gatagaagga
58921 gaggcaggtg cagcagggcc ggaggggcca cactgggggt ggggagccga gaacaggagc
58981 aaaagtgtgg tggcagttgg agaagcatga gatggaacaa aatccagcta caaattactt
59041 gcatatggca taaccaagtc caaatgacca ggaggagtta aaacaagtgg ggcaaagaaa
59101 cgtaccatgt Mattgccaac caaggcattt aaggagataa actgataaaa caaacaactc
59161 atggaaaaaa atacaaaaga tacgaaactt tatgctccta aagcttcaac ctggtgcaag
59221 gaaggagaga caaggccaca gtgataggag cactgtaata catttattcc agacaagtct
59281 gatacagcat taggtaggga tagaaactat ttgaattaat aggaaaacct aaYgttcaaa
59341 cccaacagcc agaacacgtg accttgtcaa gcacacacgg gagaagttcc acattttacc
59401 acattaggac acaactcaaa aactcaaaag ccgtgcccac agtcaccatt actgagacac
59461 attaggacac aactcaaaag ccgtgcccac agtcaccatt actgagacac attaggacac
59521 aactcaaaaa tcgtgctcac agtcaccatt actgagacac attaggacac aactcaaaaa
59581 tcgtgcccac agtcaccatt actgagacac attaggacac aactcaaaag ccgtgcccac
59641 aatcaccatt actgagacaa aatcagagat aacaataaaa ccctaaaccc taaacatctg
59701 aaattaaaag caccRttcta ataggcctag actaaataga aaatatacat tccactcatg
59761 gctcaagtag aaaacctgaa gaaaccaata acctcagaag aaaYtgaaag agcagtcaaa
59821 gaaatgcttc catagaagag tttaaccaaa Yccacaagga acagatactc ctcatctcac
59881 ataaaataat gcaaagatca agacttcttg aacataggaa taacccgcRa gaaagcagag
59941 tggaaaaaag agcttatcag ctataacagc aaaactccca agtatctaag aacaaacaaa
60001 aactaatgaa tgttcaacga ctacacaaaa agtagtataa tatagtctaa gRtctccaaa
60061 aacacaaaag aagacctcag taaatgaagc tacatggaca taatcctgga ctggaagttg
60121 gtcctcctcc aaatgaatca agaaatttgg cataatctcc atcaaataat tgttaaaata
60181 attgttaaaa ttattctccg tcaaataatc tccgtcgaat aattgttaaa attattctcY
60241 gtcaaataat ctccgtcgaa taattgttaa aataattgtt aaaattattc tccgccaaat
60301 aatctccatc aaataattgt taaaacccaa caaagtgatt ccaacattca tccggaagMc
60361 cacaccagac agaaaaataa Ygaaaaagaa tgacaatgag gaggcatatt tttttcaaat
60421 taatgcagtg tattataaaa taatattaat gaaaaYgtag ttgtgtcaat gtcatgaaag
60481 aaacagatca atggagctga ataaaacttc caaaaacagg ctgggtgcag tggctcacgc
60541 ctgtaattcc agtactttgg gaggccgagg cgggtggatc acctgaggtt gggagtttga
60601 gaccagcctg accaatatgg agaaacccta tctctactaa aaatacaaaa ttagctgggc
60661 atggtggtgc atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga
60721 accSgggagg cggaggctgt ggtaagctga gatcacgcca ttgcactcca gcctgagcaa
60781 caagagtgaa actccgtctc aaaaacacaa aacaaaacaa aaaaacttcc aaaaacagat
60841 ccaagaatat gtggggtttc caggttaaaa tggcRgattg aacacagata tctgatttgg
60901 ctcctttcta gaatcccatt aaaagttcag taaagaaatt taaaaaaaat ttaaagtcac
60961 aagcctcYaa ggataggSag agcaggaggg gaagaaaYaa caagggaact gtgggaggct
61021 ggaaacagat gggcaagtgg taacagactt ggtacatcaa gaaagctgaa tcccaggctg
61081 gccatgaaga cagccacatt ctacaaagtc tcccggagaa taagaagggg gaaaatcagg
61141 ttacaggaga ggtcatagac aaagaattgg aatcagaatg actcagagtt ctcaaaagca
61201 gcattcgatg caggaaaaca gtggaggaaa gccttcagaa ttctgaagga aaatgattgt
61261 ccaactggaa ttctgcatcc agacacattc cccatcaagt atgaaagtgg aataaggaca
61321 tttctagaca tgtcagttct caaaagattt atgtgacaag cactcctctc aagaagctac
61381 tgaaaggtgt gcaccatcaa aaacaaaaaa ggcaacaaag aaagagtaag acacagatat
61441 agaaaacgga agcccaacac agatagagaa aacgggagcc caacacagaa gacatggcct 61501 gggaggccca tggagggtgg cgagaagtga ccctgaggtg atggctctgc accagaYgtg
61561 gagagcgact gagccatact gagcagcgtg acccacgggg tgaactgtct tcaccaagac
61621 cccacctcca tcaggccatc tgtagcccgg ggacaaaatg cccaggagag cctggcctag
61681 gttcttggca gtacttggct tggccatgtg ccgatgaggg gcgctcccct cctctgctga
61741 ggacgcacaa cattcacaga agtttccagc tttcccccca ccgagagctg gaggcaggcc
61801 gtggcgagct tagaagcagg acgtacaggt cagccccctc cctctgaccg tatttccgct
61861 gcaggtccag cgcgtggtcc ccacctgggc cctaccaggt gcctgactgt gctgagccca
61921 agacttcctc gagaccttgc tcacgacttc cccaggaggg gccttgtcag ttcccggaga
61981 agcagaagtc agaccacgac ctggagactg atctgctcac ctccgggagc ctccatccag
62041 cgggggcagt gccgccctct ccttacactg ccagcgtgtg ccagctctcc Rctttaatat
62101 taatcgtctt tgatattcat ttgcatgtaa ttataaatag ttgctcaagt agcaatacag
62161 tgaataaaat tagtaaatga tacaggtagc aaacggtgct aggaaacggc ggaggtggag
62221 caggagggga caacctggca gtctggcact actgagggga tcatgaggaa gagcaccatg
62281 cggctcatat cctaaagata caggatgtct atcggatagc ccagtgccct ccttggactg
62341 acccttggcc catgggccat tgttcggccc catggactgg cttgcagatg ggcaaacttg
62401 cacaggtctg taaggaggca atggggagct gccccttgca gcattgcttg ggtggagtga
62461 ggggagctgg aaacaacacg ggggtcatca gtgggtgaga ggagaagcaa atgtggtggg
62521 ggcatcccac aaagtgctac caaggttaga agtttgatat ctacatagat ggatggatct
62581 taaaaacaga gtgccaagtg caaaaggtaa gaaacagaat gagacacaat tcagagcgac
62641 ttacRtaaat tatggataca cagacgcaag acagcaacac tcatgttgca aaaatgtaca
62701 ctaaggaaag gatacggttt gatcacctga aatggttgct cactgcagga gaaaatcaga
62761 aggaagagag caggctgggg agataaatgg cttttgtttc tttctttgtt ttaatgatgt
62821 taggacaact ggttagaggg aggaaaaggt caaattttga cctcatgcct taagcaaaaa
62881 cagattccaa gtggatgaga tgatcaaaag gaagtcatgg aagtgctaga agaaaatgta
62941 gcKaggcacc tttttatcat cttgctgttg ggcgggcttt gggttccaag cctagggctc
63001 tttcccagcc ctctccttag ctgccccatc ccctgtgagc agtttcccac tctgctggac
63061 tctgctggct gaatgcaagg gcagatggca cacttgctag gggatggtgt gaggggggat
63121 gggcacactc Wctaggggat ggcgMaaggg ggggatgggc acactcacta ggggatggcc
63181 tgagggcaga caggcacact cactaggtag gggatggcct gagggcagac ggcacactca
63241 ctaggtaggg gatggcctga gggcagacgg cacactcact gaggcacctg cacacagaca
63301 gaggtgctgt gctactgcct caacctgcca accatgtgga tgggaacaag tcatcctttt
63361 tccagtgctt aggagtcccc aaaacgtaag tcctaatgac cgcccYgcag agccagaact
63421 gccacaStgc ccagaagagg agagggaggc tcagggaatt agactaaggc catgatgttg
63481 gcaaatggcc aggccagaat gccagcccag ttcctgcaca caagcactgc cagggcctgc
63541 aggggccacc accRggctca ggaggaccaa agcctggagc accagcagcc tctcctccaa
63601 catgaggagc cccacccagg ggaggtcaac gggaacaagg tcatcccctc catttcttac
63661 Yaaccaagag agagtcgctc tgtggctgtg tattccccta aagataatca ttaagatgaa
63721 atatgtttat gtggaagtgt aatcaggaca cagcagaaag ccctgcttgg aagcaggcag
63781 gctctttgga ggctctggga agcagaaggc aggctcagcc ccacgggggc catcagcaca
63841 gagccccact ggtgtacttt attaaaagat gctcattagg attattacat cccagccctt
63901 tataacttta ttactgactt tgaattaatt tttgcaactt caacagacac agctcatcca
63961 atgccatttt tatgacctga ggtggatcgg agggtgggga ggggctcctg gggccggcct
64021 ggccatcagg agcgcatcag gaaccgctgt gccgaatctc aggggcagtc ctgacagttc
64081 tctaaactcc caYgggatgg gctgccccgc ggacagatgg acgctccagc ccaggcctgc
64141 tcagcctcag ccRtgcttca gggagaaaaa ggaagcacta aaggagagaa ggcctctccg
64201 ggccagtcct cagaacatac ccccgcacag cagaggacaa aggacacccc tcagtggtgg
64261 acacagaagg tcctggcctg cccagcacct gcacaccctc acagagccac ctggggttgc
64321 acagcacggt ggcctgccct gtctggccat tacacctttt ctgctagtaa accaccctcc
64381 cctatttgca ccccatatgg ctcatgggSa gccaatccca ctgcacccca gctccaggag
64441 tgcccaaggg gtcctgttag gccactggaa cctgatgctg tgtgttggtg tgcacaggaa
64501 gactcccgtg ctttcctctc tgctgggaaa atgtgactct gggRctgcta agtacctcct
64561 tcccccagga gcagcagagg cgagagatga gggcagcccc gtgtgctgct gacactgttc
64621 aggtccccaa atccagctat ggctgaaggt gatgcacccc tggacatcct aattcttcag
64681 gtcaattcat ttagctctct gtctcttgca accacgagag tcctgtgtgc ccttacaaac
64741 acagacacag ccaaatgtgc tggcctgaga gagacaccat ggtttggctt tgcagccaca
64801 gctctcttga acgattgagg catcagacca ggccactctc ttctgccctg tgcctgcacc
64861 tcccagtgtg gggcgaggag aaggtctgca gtatttaagg tctatgacca gaaaaggggc
64921 caggctctgg tccggctccc agatacgtgt ccttgggaaa tggtgcccag cagaggtgtg
64981 aggctgctga ggttgagccc aagccagcag ggccatgctg agtgaccagc agctgtgcga
65041 gcccctctga ggtgtcctgc agcagggctg gggcttcctg tctacagccc tcacagaggt
65101 tcccaaacac aacttccccc tcttcacccc agggctgggg cctcctgtct acagccccca
65161 cagaggttcc caaacacaac ttccccttcg tccccccagc acccgccgaa ctaccgaggc
65221 tcctctgcac ctgccccgtg ccactctcca gcggccYctg cagcccactc acctccaagg
65281 attcacgggg gtctcggggc cttcagaggc tggggcgggt gacaagagcc agcaagccct
65341 gcccctgcct agcatctgct taagccaggg agggtcccca ggactcacca cagcccccag 65401 ggctccaagc cttccctctg ctgggcagtt ggcccaggga aggggagctg gcctgggtaa
65461 tgtcacgggg gcaccgcagc acgcggcagc caagtggtgg gggccgatgg agaggccggc
65521 aggtctttta ttgaaaatat tcactgtgaa cttcagaaca aaacgaagat ccccacgggt
65581 cccaaaggaa gggagaattc ccaggggttg tgttctgaac gcagaRgagg tgggggccgg
65641 caagtggggt gctgacagcc agtgccacgg gacccatgtg gccggaggct tggccagtgg
65701 ctcagcagat gacaggcgga aaatccctgt caccagtcYg gtacatgctc cagagcccct
65761 gatttggaca tcatctggaa gcctggcatt gctccccgga aggcctcagg tacctcacac
65821 tcagaaggtc cagggcctgc tgcctcctct gcccgcacgt gcacctccgg ctgcactgcc
65881 agctgcatcg tccacctagg gagtggggcc cgcatgcagc caggtccatg ccaggagcag
65941 aacctgcctc tccccctccc tcaaaggcag ctccctcctc actcctcagg gtctctggaa
66001 cctacccctc cacgctctat gccctctgta ctgcccacgc tcctgactcc agcagcatct
66061 gcgcctcccc catctctgca ctcttcaaat ccaagttcca aggcatttct ttacctgcca
66121 acctcagttt cccttgttgt ggccttcacg tcctttgatg ttgagccctg cgttcatgca
66181 gggtgggcgt gggccctgca ggggtgaggt cctggtcccc tgggaagagc ttgcagccaa
66241 cacaagcggg aggtctcaga tgctgcccga ccctgtgcaa atgaggccct ctcctacccg
66301 gccatgagcc acgtgcaggg actcagcacc tgcctctgct ccctcctcct tcctgacccc
66361 tctaggtcag gagtccaggc acacagcagt gYtggggtgc tgcagccaag cacaggctct
66421 tcctagctga ttgtgggacc tggggcagcc ctgcacggtg ggccacactg tgccaccaag
66481 ctgccttcct aggaggaaga gttcctcaga tgcccaggca ccagggactt cacacacctc
66541 ctgtttcttc ttcatggtag ccggtggagt gggcacggga cctctcttac gcaaatgagg
66601 gaacaagccc tgggcccagg caacaggcac ccctgcgtga ccccagcatc tggctctgtc
66661 ccccgcatcc cgagcttcca atggcccatg gtggtgattg cacctggtcc agcagccaaR
66721 agggagctga aagtaccagg gccctggccc agctgaggac cttgctgcca tcacccacca
66781 tgacccttgg gcacaaagac cccccacttt cagtcgtggc accaagcaca gtccatgtct
66841 gaccaggacc tgctcaagga gcaggagtga ccgaggacaa ccccggggac caccccagcc
66901 ctcccccatg ctgggggtgg aagggtggtg aggcctgggg cctcttgatg ctcccatgcc
66961 ctgatgtccc atcctccagg acgctcccat gcccctgcgc ctcctgaggg ggcagggaaa
67021 ccccatgtgg gcgggcagca gccaggctcc ctggatctgc ccagagaaga gccccccgca
67081 gaggtgatgc aatgctcacc acgcccccct cagctcaaga ccctggaact tgccagaccc
67141 tcagccctct ctcccagtga gtgtcaggga cctccctttc ccctcaggct gctgggcccc
67201 caaaccacat gtcctccttc cctctgctcc agccccccat ggggctgagg agcaggcctg
67261 cccaaccttt gtttctggtc tctcctgtcc ttcacgcctg gctgtgggat cttctctcag
67321 acctgcctct cccacgggta aatcccaagg tgcagactca gagacagcac cgagaggccc
67381 ccagtgcagc cgccactctg agcccagagg ccaggccatc caaccctgca gggacggggg
67441 ttcctcccat ttgtcttcct gtgtgaactc cgtgggtcca gaagcctgag tttgggggtg
67501 gtgacaattg gccctggtgg accccacaca ctcctgtccc atgatgcttc ctgccctaga
67561 atatcccagc tgcagttgag gagggaaggg gctcctcata ctccccacac agcacccaga
67621 ccacggtgtt gacgaggctt aatttgatca gccctatttc gagaagggag gaaatcagaa
67681 atcagagtga gtgctgagtc ctgaaaattt aatccccaag gcagcctcac agggcctttc
67741 ctccccaacc ggggcaggtg gcagggatgc actacaagcc cagatcccag ggccaccctg
67801 agaaccagga ggggagggag ggccaccctg cctgcagaga ggatggcaaa ggccctgctt
67861 gccgggcccc agctgccctc aacactgcaa gggctcagaa gactggacca gcagctggcc
67921 gggcagaaac tatagaaatc atcctaattc tactttaaaa ggctggggtt tcctcttctt
67981 gcttaaaagc tggtgtgacc cttccaggta gcagccagcg gcaggcctgt ggctcactga
68041 gatgggctgg gtgggtggcc ctctggcctg tgctcccaac cagctgccca tgtgctcctg
68101 cctgccctgc agaggtgacg tggctgccat cacagcattg catgttgtga actgactcct
68161 gccaagccct gagagggcat caagtctggc agcagcccct gcagggccca gctgcctccg
68221 aacctccagc atgcttctcc cagggcagga gcaccctccc cagagcaccc agtcctgttg
68281 ccactttctg ccaggcaacc cctccccctg cttccaggtc cagcctgact ttcctcctgt
68341 ttgcaacagt tcctacctgc ctgccctggg cccatgccct ccaccaggac aagtcactgt
68401 ctccttctct ggctcccaaa accttcattt tcattcattt gttcattgtt cattcactcg
68461 tcaagtattt tgctaactac catttgccag ccttgcgtgg caccacctct aggagagcgc
68521 tctggggtgt caccatcaca ggctggcctg ctcagtgatc actcctcaga cacatgcaca
68581 cacacacatg cacgcagtca catacacaca tgcacactca cacgaatgca ctcatacaca
68641 cacacacgaa cgcactcaca tacacacatg cacactcaca caaatgcact catatacaca
68701 cgaatgcact cagacactca caaacacgca cacacgaatg cactcacaca cacgcatgca
68761 gtcacataca cacatgcact cacacgaacg cactcacaca cgcacactca cacacgaatg
68821 cactcacaca caaatggact cacactcaca tgcacactca tacgaatgca ctcacacaca
68881 tgcactcaca ctcacacgaa tgcactcaca cacacgcgaa tgcactcgca cacgcatgca
68941 ctcacgcgtg aatgcactcg catactcaca tgcacactca catgaatgca cacacacata
69001 cactcacaga cgcacactca cacatgaatg cactcacaca cacgaatgct cttacatgca
69061 cacaaacgca catgcataca ttcatcacat gtgagtgtat gtgagtgcat gtgcgtgtat
69121 gtgagtctat ggatgtgtgt gcatgtcaca cgtgtgtgca tatgtgacat gcacacWcag
69181 gcacacacat gcacacacac aaacgtgcac atgcacacac aggctctaca gtgaactcct
69241 ggaagactga ggtggccctt gacccctctc taagtcccca ggtacccaca tggggcttgg 69301 caaaatgaat aaataaacgg gccaaaaacg cctatKggat aaatggaaaa cttagttatc
69361 cttatgctac ttctgagcag gtggagacag gacagggtag gacgaggcgc agcgtggatg
69421 cgggcggatt gtctgtatct ccttggtggg agcagttggc cgtggagtct acatcggttt
69481 ccttcctggc cgtcatttac agggagagca tgagggcggc gtgaggtcag cggggcaggt
69541 ggatgctgtg cgcttactgc agccatgcgg tgggtgcacg ctaccaccgt cttctcctct
69601 ttttcttggg agctgtcgcc atggctcccg gcacaYcctg acatccgtag gcgccatcct
69661 gacaacacgc tgccggccgc aggcctcaca ccacagcaat tctcactcgg gcctccctga
69721 ccctcgacct gtgggtccct gctaggctgg gcgtgtttcc cgatgcccca tctctctgac
69781 ctagacatat tttgttcaca tgttgaacag agagaaacgg tcYgcatttc cagaaagaaa
69841 tatactctcc caattttcct tggagcatgc ggccctcttg gcttgtcttt tgcttattcc
69901 ctcttcactg agaaatattt tgctcccRtg agaaaagcca tgtgggcagg gggatgagag
69961 ggcacactgc ctccagccca aggtggccag tggtgactag gagggtgcag gtccatgttg
70021 ctgggtctta tttttgtaag gaagtgagaa atctggattt gcatgtgaag tctctgatct
70081 ctaaatactg gcaaaaagca atttaagaat aatgtaggtg ctgtgctgct tgtgaaatga
70141 accaaagctg ggtccccagg tctgtctgcc acctcagctc cacgcccaga ccaaagctgt
70201 gtcctcaggt ctgtctgcca cctcggctcc acgccctgag caaccgtttc cctgtatcct
70261 cctccgtctg gcctggagag gttttgagca cagtaggttc tggccaacca gagtgagtcc
70321 acctgcctct gcctcacagt ggctgaagct tcccgggccg cagttcacgc cccacttgtt
70381 tctccacatc cctttcccac cttgaaggac agctcctgat ggatgtgttt tatggtggaa
70441 tcctcacgca ggggcctgag gaacactccc tggttatcca cacggcaact aacactcagc
70501 acgcaccagg ctcctcctcc ctctcatgga ctctcaattc agccccRcac agccaagggc
70561 tcacccacat catgtgcgct tcagacaaag gactaatttc cttaatacat aaagcgctct
70621 tacaaatcaa caRgaaacaa tccagcaatc caaaagggaa atggacaaac ggtattgata
70681 caaaagtgct gggtagagaa gggcatgctc cctttaaatg atatggaagc agggaagtgc
70741 atggtccctg gctaagggct ccaccctcac ggacctatgt gaggacaggc actcttgcct
70801 ttgtgcccaa atgtcacatt tcccaagacc accctggtcc accatgtccc catcctgtgc
70861 ctataaaaac ccgagaccct aacaggcaga cacaggcggc tggacgtcga gaggagcgca
70921 tgaggggagg aacacacagg cggctggacg tcgagaggaa cgcaccaacg agcaccagca
70981 cgctgcaggc caccgaccgg cagaagcaga acgacacgga gtttggccgg ggcagtcaga
71041 ggagagccca ggctgcttag cggcccgact ccagggaaag ccctttgcac cccatcctcc
71101 ttctggcttc ccccatctgc tgagagctac ttccactcaa taaaacctcg cactcattct
71161 ccaagcccac gtgtgatctg attcttccag gacatcaagg aagaacccga gatacagaaa
71221 gccctctgtc cttgcgacaa ggtagagggt ctaactgagc tggttaacac aagccgccta
71281 cagacagcta aagtaaaaga gcacatgcag cacacgccca ctggggcttc aggggctgca
71341 aacattcacc cctagacact gctgtggggt cggagcccca cagcctgccc gtctgtattc
71401 tcccccagag gtttgagcag agggacactg aagaaggaag ccacaccccc atagcacgcc
71461 ctgcgaggag gacaagagaa cttctctcat ttcaatatga ggggacaatt gtcagaaaag
71521 aaaagacagc agcttttctt ttcttcttta tctctttctt tctttccctt ccttctttcc
71581 ttccttcctt cctttctttc tttcttctct ttcttctttc cttctttctt tttttttttt
71641 gagacagagt ctctgtcacc caggctggag tacagtggcg tgatctcagc tcactgcaac
71701 caccgcctcc cggattcaag cagttttcct gcctcagcct tccaagcagc tgggattaca
71761 ggtgcctgct atcatacctg gttaattttt tttttttttt gtatKtttag tagagacagg
71821 atttcaccat gttagccagg ctggtttcaa actcctgacc tcaggtgatc catccaccct
71881 ggcctcccac agtgttggta ttacgggtat gagccaccga gcagcttttc agtgtatgag
71941 aagacgctcg acctcaccct taattaaaga aacaacctgc atcagattgt ccaaataaaa
72001 atgtacggat caggggtaca tgctgagaga aacggatcca gccaaccatc ctagggttgt
72061 ggtcatcctt atcaaagttg aaaatgcaca aaccttttga atccacaatt ctagttatca
72121 aatttaatcc tacaaatgtc ctcatacaag tagccaagga aataagtgta aggatatcca
72181 Sggctgcatt ataagaaacR gtgaaaagaa gtaacgtccc catcagtcaa ggtctggtta
72241 agcaagtgat tcacaggatg gaatgcctga gcaggaggaa tgggcaggtc tggaggggct
72301 gctgtggacg acgtccaaga catgttccct gataatcgca aatgcagggt agcacacggt
72361 gtagtctaca gtgtgcagga aaaagtcaga aaaacgaaaa cacagtatct acaggacaca 72421 aaatcccttg agccagagat tctaatccta ggatttatat atgtgtgtgt acaNatgtgt
72481 atatatatat acttgtgtgt gcacaggaca tcctgaaagg acacagaaga aaggtgtgca 72541 gtggctgccc tgcagaaagg agctgaSttc caggacagcc aatgggaggg ggatgaggac 72601 agcaatgagc atttcatatg gctgcaatcc ttagtccagc caaaaagcaa gccacgcaca 72661 tgcaggagag gccaggactc tcccagcagc tcccccaggg gtcaggggca gagggagccc 72721 ccagcctggc ctgctccctg acgactctac acttggcagc tgaagggggc caccctgaca 72781 gtcaaggccc agctgtgatc tggggtggaa ctggtctggc accgatctgc ttggcctggc 72841 tctgggtgct ggcacggcag tatctggtgg gctgcagggc ccccagctgg ggccctttga 72901 gtgatgatga gcctgctggg ctgggaccac agagtgagca ggaccagcat cccctcaacc 72961 ccagatgccc tcYaggactg cagggcccag acacagagag ggaacctgac gctcatgggg 73021 agggctgaga ggcaggcaga gggggaaggg tgttcctgac cacggcccac aggaccagca 73081 gtgcagaggg cctgggagtg agggaagccc ctgctgtgcc aaggagggag ggccaggaga 73141 ggagagatgg ccgaggccgg gaggagggca gaagtgcaga gagactagag ggggcagggc 73201 agccctggct tggggctgga gagggagcca ggaaggaggg tggaaggcag gggaggcagc
73261 gtgtggacaa agactgagag ggggagtcac agcttgggtg cagaaagtgg ggccagggag
73321 gattccgggt ttctgacctg ggcaaccggt caccctggga agccttccct gcaagggacc
73381 ctcgggagga gccgcgtggg aggaggagaa ggccgtgtgg ggcgtgttgg gctgagattt
73441 ctgtggggac acaaggacag acacccaYga gacactcagg caggagtggt ctggagcaca
73501 gagagagggt gggccggagg ccccaggtgt gggcggcctc caggatgaat cagctgcaga
73561 gcaccgcagt ggcgcacaca gatcagtgtc ctgatctgaa aagtaggcat aacgatgctg
73621 gccacagccc acaagtaaga cacatagaaa acctgaggcc cacagaggtg acaggaacgg
73681 gccaggtgca cggacagggc tgttcctgac tcagctcact ccaccagaac ccagtctggg
73741 caccagcctg ttttcttgtc ctctccagcc agcagggcag aattgggggt ggacttgccc
73801 cagcctgaag acctccgggg ccctggctcc tccctgctcc acctgccata gcccaaaacc
73861 agtgtgggtg tgaagcggaa ggagactcYg cagcaaggcc cagctcttat gccggccact
73921 gccttgcctc ctgcctgatg cagtctctcg gcagcaaggc aggtgccctg agacctggag
73981 gtgcccccag ccccagaacc caccatgcgc ggctgggccg actgtgcctg cccttaaggc
74041 aggcagaaca ctaaccaaag ccagcggaca tccactgcct gcggagcatc tggggaaggc 74101 tcctgtgggg ctccagaccc ggggcggtgc cttcaccacg gcctcctcat ccagcatcca 74161 caactctgga gctaggaagc ccggtgctcc ttcccagagg agggagccga agctctgcca 74221 gtctgcactg aagtctgtgg tgtgcggtca cctgagaaca gctcagtcag tctggctgga 74281 tcctgagctc ctcccccggc ctgtgcttga gaggtgacag ccagcacgtg agcaagtgcc 74341 ctgggttctg gtcccagcaa agctacctcc agctgtgcac ctcggtcagg cacctccagc 74401 tgtgcacctc ggtcaggcca ccctctctcc gtcagaccct cagtgtcctg atcagtgtcc 74461 acaagtaaga cacatagaaa acctgaggcc cagagaagcc aaggaagtcc ttacaggctt 74521 ctgtcagaga atcggaggaa aggaggggac gccagagaat ctgggcttaa gtgacttggc 74581 cgtgatcaaa acacaggcag agtcacaaac acgagacccc gctgcccact cccgacggag 74641 aggtaattcc acaaacacga gaccccgctg cccactccac aaacatgaga ccccgctgcc 74701 cactcccgac ggagaggtaa ttccacaaac acgagacccc gctgcccact ccacaaacac 74761 gagaccccgc tgcccactcc cgacggagag gtaattccac aaacacgaga ccctgctgcc 74821 cactccacaa acatgagacc ccgctgccca ttcccgacgg agaggtaatt ccaggtcagt 74881 ggcatccagc cttccccggc ccccaggccc ccagctgcca ccaagaaaca ctctttgtag 74941 gggtcctgcc ccactggggt gcagaggtac atcccccaag gcccagcccc gcaggaagcc 75001 cttcctctgc agccattctt gaaatcacct ccaagaaaaa agaaatgctt cagcttccaa 75061 agatatcccc aggcaggaaa tgggccgcag gcagcatgaa tgtttaatta cgttaattgt 75121 ccaagtccag cgcacatcat ccctcctaag taccttatgg gaaatcgtaa ttaggcgtga 75181 aatggctcat tttcacaact cccctttctc ggggttctcc agggcgcatg cccctgtcag 75241 ctggccggac aggcctctct tgccaaggct taccctcctt ggttctaatt taattttgtg 75301 accttttctc tcgacatcct gaccccgtac atccctgcgc cttggcacac tgcaccaaag 75361 caccatagaa ttactgagct ataagcctct catggaaatc tgtttttgac tttgttagaa 75421 aacactataa tcaaatccct gagagtcagg agggatgggc ttggcctgcc agaggaaaca 75481 tatcaccgga ttaagtgatt tagcagaggt ggtcccggcg ggaggagggc agggcaggct 75541 gggcagggct gggcgtgagg tgggcaggca gggtgccctc gggggcaagg ggggagggga 75601 tgcgcagagg cagaggatgg gcaatgtggg attaccagaa agtgcggtct ggacatccca 75661 gggcctgcag gcttcctgag tgcctacctg gccctgggca ctcacagggc attgatgccg 75721 agatgctcaR ctgtgcagag ggtgtgcagg tctggtggtc acttatgcgc tccagggcct 75781 gcttctgctg atgccagggc aagacccagc ctcaaacaca catcaaatac atacgcttga 75841 cgttatgccc gggagggctg tgcacacagg cacacagaga cggtgagact tggggatact 75901 tgggtccagt tactgtcacc ttgggtctca cttctgggag cgtggatttg gctggcacca 75961 ctgcactgcR gtgtgtctgc gtctatacag acttcctcca tttcacgcat gtacctaaaa 76021 cataccacca ttcatgtact gtcaggcact ctttcatttt gtaaaacaat agggttatca 76081 aggcctgcgc agtggctcat gcttctaatc ccaRcacttt gggaggccga ggcaggcgga 76141 ttgcctgagg tcaggagttc gagaccaggc tggccaacat ggtgaaaccc catttctact
76201 aaaaatacaa aaattagccg ggcatggtgg tgggcgcctg taattgcagc tactcaggag 76261 gctgaggcag gagaatggct tgaacccggg aggcggaggt tgcagtgagc cgagatcgtg 76321 ccactgcact ccagcctggg cRacagagcg aaactcagtc tcaaaaaaaa aaagccgggg
76381 gggctaccaa aagatgagag ggacccaggc ctgtattgca catccacatc agtgacagtg 76441 taatggtaYg cagaccccct ccccRcatgc acacgcattc tgaaataagc caggcccaga 76501 aggacaaata cggcactcgt ccactcacat gaggatctgt aatcaaacgc atgaaagcag 76561 atgacaccat agaggctgcc agagctgggg gagcgggaaa tggggagttg ctgttcaatg 76621 ggtgtaaagt tttagtgatg ctggacgagt aagtactaga ggtctgctgt acaacgttgt 76681 gcctgtagct gaccatgtgg cactgtgcac ttcgaaattc tctgagaggt ctgagctcac 76741 gttaagtgtt ctttccacaa aagcaaacaa caacagcaac agaaatgaag Kgacagaagg 76801 aaaccgtggg agaagacgag tgtctaccgc ctcgatgtgc tgatggcgtc ccggtgtctg 76861 cacaaatcca cacttgctga actgtaaggg gccggtgacc tctacagtcg cctaccatgg 76921 cgagcataaa cttgcagaga agaggatgag aattctgata ataggacaaa tcaaagctta 76981 acaagtaatt aaaggacaaa ttggtgcata taacaagtcg ttccctgtct cgcagctgac 77041 atggatcaat gtccaaaatt tttatccaaa ttgttataaa tacacatgag agtcttctcg 77101 gtgcagtgaa tagtgaagtc agcagaggca gtggctcacc cctgcagtct cagcacttta
77161 ggaggccgag ggggtaggat cacttgagta ccagagttag aggctgcagt gagccatgat
77221 tgtgccactg cactccagct ggggccacag agcgagaccc tgtctctagg aaaaaaaaaa
77281 agaaaaaaga aaaagaaaaa aaaaaagagg aaattagcca atatcccaga gagtgaaggc
77341 agaacccgta tcagcttttg ccaaaaatga gaactccaca gttgcctccg cattctgtct
77401 tttaaaaagt gtcaatttta cattatgaaa tagagtgcat ctttttaaag taaaatcgat
77461 gctccaggaa gatattccac gtttatcctg gactttggtg ccctctcgac acttggtttt
77521 gattaaatta atccaaactc cagtttgcta agccagtgca cctgtgtgcg gctgttacat
77581 tgcaccaatg ttttatcaaa tctccgacta tgcccaagtg cggcgccatg gaagccacac
77641 gggatccctg acagacagaa acatccatac tgctcttaag gtggctcagg cactgttcca
77701 agcacctcgt ctatagttgc ccactgattc ttcgcagcag ctgtgtgagt tagctgtgat
77761 gcttatcttc attctgcaga tggggaaact gagaaaggct atcccaattt cacactgctc
77821 ggaagtgtca gaaccaggat atgaaccctg gcatggctac caagagtctg tgctcttgaa
77881 cgctgtgcta ggccactcct tctggggctg ttacatttta actctgacat gtcaagcaaa
77941 tcactataag tttattgagt catttcttag ctgcttcatc tgtaaagtcg ggtgacaatg
78001 gctgcaggtc ctgccactca gacgattccc acgcgtgtct gYatcaggat gaggatgagt
78061 agatcggtaa agtgccttgt agactgtgat gatcatattt ttgtctttga ttccactgcc
78121 agcacaatac cttttttttt ttaataaagg gctgttgaac tgcaattccc atgtttgtat
78181 acattcttct tctgtttctt tggttaaagt ttcaagattc tcttagggtt caaatgttta
78241 aatttcaaat cctttggctc atctgactaa ttacaagcat aaaatatggc atttccaaca
78301 agtctggaga atggaagcac atgaaattat gcacgaccat gagcatctgt gtcgggaggc
78361 gggaaggcgt tcacccttca aactcaagtg aaaaaggttt gccgtagtta aaggctgctg
78421 acaaataact actgttctga gaaatcacca ctgtttactg ggagaatcgt ttttcagcaa
78481 atatatcaag aaaagtaaat atcaagtata atttgcagag ttgcagataa ctccacattt
78541 tggaataaaa aacttctgtg tctgtgtaca agtgtgcaaa acacagcaga gacatttttc
78601 tttccaatcc tgcctaaata ctgactgaac atcatcagtg ccatctccca tgactgtgac
78661 agtgtatctt gtgtgtatgt gttgtatcat attatctgct ttgttaaatg ctatgcttgt
78721 taaaatgtgt cacattaaaa aacaaaaaca gcccgggcat ggtggctcac gcctgtaatc
78781 ccagcacttt gaaaggctga gggtggggga gggtggatca cgaggtcagg agttcaagac
78841 cagcctggcc aacatggcaa aaccctgtct cctctaaaaa atacaaaaat tagccaggcg
78901 tgttggcagg cacctgtaat cccagctact cgggaggctg gaggcaggag aatcgcttga
78961 acccggaggg agaggttgcg gtgagaggag attgtaccat tgcactccag cctgagtgat
79021 agagtgagac tccgtttcaa aacaaaacaa aatgaacaaa caaacaaaac aaacaaaaac
79081 aaaaaaacag aaacacacac tacactgact acactgaagc cctcaagccg ctgagcagcc
79141 atctccaggt ccccaaggac caggcaccaa ggtctggggg tggcccagca tccattctcc
79201 cctttctcag agcagcagcc cagtgttatt tcctggaatt cctggaaccc tgcatgcaca
79261 cagccctccc caagccaaac atcctctccc tcacagagtg tgggatttga gccgcaggag
79321 ccagaagagg aaaaggtagt ggtgtcacta aacacctggt cacaatggtt aagaccctcc
79381 tgtgtccagg accccgactg ccaggccctt ccacagcccg actccccgtg gactctgcag
79441 gtttcctaat gtcctcccag taactcttcc tggctcaggg cagctggact tcatgcaagc
79501 tctctgccag aagagaccct ctcctgccac aggcgccctc cccatcagat gccagagata
79561 tcaccagccc tcgaggctta acccctgctc tgtgggggat tcctgctgct ctgcctgaat
79621 tcacccaggt gggcagtcct caggtgactt ctccagctct gcatggagaa ggcctcacca
79681 tgcatctcag agagaagtgg aggctgcacc cccacaggaa gtggggccca gtccaccgtg
79741 ccctggacgc tgctcatcca ctaggactgg gcttccgtgt gcagggcttc accctcgctc
79801 tcctctctgc ctgctccaca cctgctgctt tgacctccat gaccatggac ctgctgacag
79861 gtgccccccg acccacctcc agcctgcacc tccccaggct ccagaccccg ccccctgctg
79921 cctgcaactg cccctggggt gtcacaaggc accttcatgc caacaagtcc caaacaaacc
79981 tgtcaccttt ccctacccca acccatcagc cattgctgct gtgcccatct catctccaca
80041 tccaaggagt caccgcatcc tggcaccttc cccatctccc cgtccatgat gagctcagcc
80101 cctccctcta cctggatgca gcagcctcct cccagacctg gccccatccg ctgctgctcc
80161 ctgcccttca ctccctgtag ctcgagtcct cacctgagct tgcccccatt aaaatcctct
80221 gtacctccct cttcccaagc ctagcagacc cgtgcgggag tgcgagcaca ctggctaggg
80281 cctcctgatg ggcctgacct gcctgccaac cctcccaggg acctgctcat gttcccgcaa
80341 cgcccttaca gccatgggtc cgagaaaaca ctgctcactc tgcccagaat gcctgccctg
80401 ccctttctgg cagactccta ttcagtcttc aaaacccagc tcccagctcg ttaggcccgc
80461 aaagagagca agttactctc tctcctagac tcaagcaccc tgtgcttcct tcttttaaac
80521 cactgatcat gcagaagtat aagctcacca gtttccaagt cccctaacca gaccatgagc
80581 tccaggggta aaatcatgca tcagattcat ctctgggtca cctgccttgg ctgagaggag
80641 gctcatgaag gtttggcaca atgggatgaa ggaatagaca aggagcaaga atacgagctc
80701 atcctcatgc ctcagaatag catgaaatgc tcagggtgtg tgggacagaa ctgacgcYtt
80761 cacaccaatg gagccagRtg ccagcctatg tgtgtccaag tcctaccaag tcccaggctg
80821 catggaaatc agagggaccc caaatcgaat gagcgagggg cccttaaaga aactcacctg
80881 gcccctttgt ctcaggtcct aggggttggt gctgccagga actctcatag gagagggcct
80941 tgttcccacc tagtcccaag catctgagca gggccaacga aagtgctggt aggccaggcc 81001 ttgccctgga gaggaagggc agagaggaag gagaggggaa gcggggtgga ccacctctgc
81061 tcagaccaaa ggcagaatcc agtgctgatg gttgccaata gggtcctctc tgttgctggg
81121 cccccatgaa ccatgtgagc cctgcacaga gctcctgcta gatcctgggg gtctccctgc
81181 actgggattg ctccaacagt gcccccaccc tcagggcatg ggttgccctc tgcatctggc
81241 caagtgcctt cccagacacc ctgcagcctc agcctcctgt gaccactcat gtccacctag
81301 cctggtcctg gtcccaggtg ccctcctggt ctagctgcca ctaaacagat gagaaKctcc
81361 ctcccatccc agccctgaaa tatgctcagc ctcaaagcct cttggcacat ctcagcttcc
81421 agatgtcctg tgccttgtga gatattaacc acactctgcc tagccctctg ccatgaggtc
81481 agctccgctc ccaggcaggg ggaagagctg ccttgggagc aatgatgggc atcgtccctc
81541 tgtgctgtgt ttggggtctt ccctccctcc aagtcYtgga ctttgggccc agaaatcact
81601 ttccctccct cctctctgag cacacaaagg gcaggacttg tcttcaggtg cttggggaag
81661 agggacgcca attgttccag ccactcccRt aagggtgaac caggagacta accatcaaat
81721 tcaccaggaa atcccaacct ccaggccctg actgaggcMc taagacccaa gcaagcaata
81781 tcaatgaaag ccagaggtgc ttaaggtggg gaacaagaat gagctgtcag aggcctctga
81841 taaagaatcg tttaaaaaga ctttctttgc tgcggctcat gcctgtaatc ccagcccttt
81901 ggaagtctga ggcggtagga tcacttgagg tcaagaattc aagagcagcS tgggcaatat
81961 ggtaaaaccc tgtctccata cacataaaaa aaattagcca aacgtaatgg ggtgcacctg
82021 cagtcccagc tactcgggag gctgaggtgg gaggactgac tgaccctgag aggttgaggc
82081 tgcagtaagc cgagtccatg ctgctgcact tcagcctggg tgacaaagca agacctggtt
82141 tcagaaaaaa gaatttcccc cttcgatgta tgctatggac tgaatatttg tacccccaaa
82201 attcatatgt tgaaacctaa tccccagagg gatgatttta ggaggtgggg cctttggggg
82261 gtaattaggt catgagggtg gggcctcatg aatgggatta gtgcccttat caaagaagcc
82321 ccatggccag gtgcagtggc ttacaccagt aatctcagca ctttgggggg ttgagacggg
82381 aggatagctt gagcacagaa gtacaagacc agcttggtta acacagcaag ccctcatcac
82441 tacaaaaact aaaaataaaa aaaaatatgt tgcatgtggt ggctcacatc tctagcccca
82501 gctacgtgag aggctgaggc aggaggatcg cttgatccca ggagttcaag gacacagtga
82561 gMtaggatcg tgccactgca ctccagccta ggtgatgagt gagactctgt ctctaaacat
82621 ttttttaaat taaaaatgta gaaataacat aaaagaggcc ccagagagct ctcttgcccc
82681 ttgcaatgca tgaagacaaa gtgcaagaag gtgccatgtg tgaaccagaa ggtaggccct
82741 cagcagacac aaaatctgcc agcactttga tcttggactt cccagcctcc agaaccatga
82801 gaaagaaata aacactatgt aagccacctg gtgttggggg tgctttttgt ggtagcagcc
82861 tctactgact aagacagtgt cacttcagct actctcaaga aaggcttcgt cacctggatc
82921 cagtcgcgtc agttaagcgg tgctgcccag ctctgggagg ctgggggaga tgaggcgatg
82981 tgtgattctc aaggtcagca tgttggaaag tctagcaggg tttaatgagg acggaattaa
83041 aggagacggg gcctgatgag gggctctggg cctctctgtg tccctgtctg ctttgtctgg
83101 aaaatggtga aaggaaggag gcatcttgga gcatctgtgt cctctggttt tccttgatcc
83161 ctggattcac caggacacaa aaacccagtg cttcttgtac tgcaaggtgc ttgagaaagg
83221 aagagcaaac ccacaagctg aagagtccca ggcagccatc gctcccgaca cgcacgccgc
83281 agtgtagctg tggctcctga gaacggcggt gttaaaggac agttacttaa ccagaacttg
83341 gggtccccct gccccgcccc acggaggcct tgaacatcct acaataaaca cacaccgaag
83401 ccatgttctt ggagagactt tggggaggct gtgcactctg gaaacagcca agctgttctg
83461 tggcttggaa gaaacaagca gttccatcca ctctgggctc acagatattc ctcctgagct
83521 tgaaggaagc cacagcggaa cttggagctg ctctagttct ctggaacatg cagcaggtgg
83581 aaccgcagac Rtctctccag ggagctgagt cccggttttc acctgctggg tgtccacgga
83641 ttcaccccca gctactgtgt aggggccagc tcccctcagg gactgctcct gggagaccgY
83701 gggagtcacc gcagctccct gctctgtgga gcggccacgc tagcagaagg aacagagggt
83761 gccagtgctc tgagtatgcc ggagggcagt gagtgctgcg ggaaggggct ggagggcaca
83821 Sggtctgcga gtgccagggc aSgtggtgcg gggggagctg tctacaaagc cttagagcgc
83881 cagggtaggt cccactggaa gggaacatgc aagcaaagac tcKaatgaKg tgggagggtg
83941 agctgagggt gtctagaaag ggcatccagg cggaaggagg accccatgtg gggttttgaa 84001 aagaagggca aggaggccca Sgatggcagg aatcaagtga gtgagaagga aaatggaggc 84061 cacggggtcc cagggcgagg cgctgggtcg tgtggggtct ggtaggtggc ccgggtgctg 84121 ggtgctgact tctgagctga acgaagcagg agccactgtg ggatttccag cagaRgacag 84181 acatgatcca gcagaaggca tcaaaggatc cctgaccacg gaccgcccca ggacccttcc 84241 accatagtgc aggattcctc ttacaggaaa tgccccagta ggcagatcta gagaggcagg 84301 aagtggatga atggttgcct ggaaggtggt gggggaggaa ggacgacagc taaggggtgt 84361 ggggtctttg gggagggaga agatgttgtg aatataataa aaaccattga atcgtaYact 84421 ttaaatgggt gacctgtata gtatgtgaat tatatctcaa taaagctgtt agagaaaaga 84481 atccctgctg ctgtgttgag gacacatggg ggtggggagg cagggaggtc tgctgggggc 84541 tcccaaagtc atcagaagag gacaaaggct tgacgcaagt gacaaccgtg gagatggtga 84601 gaagtgatca gggtcggggt ggattttgaa agaaaaccta aaaagatttc tcaacaggtt 84661 tctcatcagt gtgagaggaa gagaggggtc aaccctaact gcagagcttt ggctgtgcaa 84721 atggaaggaa ggatcagccg tgcacaSagc tggggaaggc cgagggtgga gtgcggagag 84781 ggtgagcgcg agttcagtga ggggcgtgct gaggtggtac ttccaaattg aggttggcaa
84841 gtagagaaat gccttggaac ttggatttga agagtgcaga gacagatgag gtgcagattc 84901 tgctggagtc aggagcgtgg gcaatacaga gagcatggaa ggtggagggg cagttggaat
84961 atgagtcttg ggtgcaggag agagatctgg gctggagacg caaatctggg agccatttca
85021 tggtacataa agcaacaaga ggaatgagat cgcccacaga ggggtgcaga gggagaccaa
85081 ggagcgtcca ggacagagcc ctgggcgcat caaccccaga gggtgcggga agaggaagga
85141 tcagcaaagg aaacggggat gaactgtgag tgctgtgatt agaccaagaa agtgggtgtc
85201 cggtaagcca caccaaggga gcaggaggga ctagcctgcc acgtgctagg gatggcgact
85261 gaggattggc agggagatgc agcagcatga tgacctcggg gagggtgcct ctggcagagt
85321 ggcacacaca gaggcctggt ccaagtgggg ttaagacaca gtgagaggag aggaatcgaa
85381 gatggcgtct ccacctaggg ggtgctgctg agagagcaaa aagctgggag agtaggtgac
85441 agacgaggga agccgtcagg tgtgaatgcg gatagggagc agatgttgga ggtgttcaga
85501 ggacggaaga tatgaaaagt catctggaag gaggcaaaca gactgagggg agcagtctgg
85561 ctgctagcgg caccttgctg gtgaacatca tcgtaagcaa gagcagaagc agggctgagc
85621 tttgttcagg ggtacccgtg ccagcatgaa gtaggtagaa agtttcattt taccaggact
85681 agggcattgt tcagtagatg ttacaaagca agagtgactc caatgaggga acctgcagtt
85741 taagaSaagg aggctgggta aggggtggag ggaaggatca gtggtgtgag agaccgtgac
85801 aaggcggcag catcaatggc ctgcaggttt gctggagcac aggtcggagc aaaagggaac
85861 cgggaaaata gaaggtcatc agaatgcaac actgcaacgg attatgcagg tataggggcc
85921 gctggcaaaa gaaggtttaa ggtatgacca aggccaaatc cagtggggag tcctttttgg
85981 aaaccttgac agctgtggtc atggtcgacc tcatgggaaa ttttgcaaac ttgatcctgt
86041 gtcaaatgag ttcccgtgac gcgtgtcagt gcgtgtggat cttgctgttt gggggagggc
86101 agaaactctg cagaccccat gccttgccRc cctcgaccct gatacgcgat gccaatagac
86161 acactgctgc ggaaaccata aacgtcacca gattcagagc ttgagcccac ctctcccaga
86221 ggttttgtcc ggtaaaggga agaggaacag ggttcaactc tcctggcaga actctatgga
86281 tgccgcagaa gacaacgtta atgagcttgg cttaacttac aagggatttc cggtYttgtg
86341 aaagaggagg aaactcaaat ctcaggagag tttaatggca ggagtgagct tgagtgttgg
86401 tttccctaat agatgggttt agctgcatgg gtgaggtaga ccaaggccct ctgtagaata
86461 tgctggagaa caatgattca agactacaaa gaaactgaag tgtgagcgga agataggagt
86521 gaaccttcga gaaccggagg ccatgccact gccttgtttc gggtggagga acaaagcctt
86581 gtcactgtgt tgccagggac agagtgcaag gtgcctggaa gctcctcggg aacgttagct
86641 gtgtccctca tcgcaggcaa tgggaccctg caccagtggc cagtacctgc tgccccagcc
86701 agcctctgtg aggcacacac tgccagagat gacctcacgc tggtggaaaa cgaggagaca
86761 gcagatcaac ccagccgggc ttccacgtcc agcaaaacga ggcgagttcg ggttgttatt
86821 ctgctctttc atgagtcagg gctttgggcc tcactgcctt ccaaacagag tcaaaatcaa
86881 tttgacgttc aaaacgacat gaaaattgcc atgtcaaagg ccattctgta atttcagtgt
86941 attaaaatca aaagagcaca gccttcttga agaagtttcc tttgggcaga attcaagttt
87001 cctctttctt ttacttgtgc aatttgaatt tatttcactt tttcaggaag tgaccatttt
87061 tgcaggaaaa gtgtagtcaa aagagataat gcacatgaag tttcttttta agttctgagt
87121 atgtcgaaga gatttacagt gcattaaaat aaactatagg caaaatagtg tgtgtaccta
87181 tctctacgca ttttttaaaa ggggcaagtg ggggaccatc ttgttgattt ttcacaccag
87241 tagccccttt ccgccagcgg gaagggcctt gccccaccca atgtgtctct ggtggatggg
87301 taattcatgc ccatSctact ccccagtggc tgtggtgggg gggcacatag cccacacctg
87361 gtactcaatg ccctcagcac agtgattggt ccagggggtg aacacatgac tggagtgaga
87421 ctaatcatgg gtcttccatg agatctgaac attgggagaa aaaaatattc ccttcctggc
87481 tcagtaagct cacagcgtag gcctggggct gcgtatgtga agagccaatc tgagaaggaa
87541 gtctctgcag aagagagσca agtcctagga ggaggagaga cgctgagcct tggcagcctc
87601 gtgtgggcca gcggtgcctg ctgtcttgct cgcgtgtgcc agcaaatYtc cttttcttgg
87661 cttaattgga tttggatctc taattatacc ttgaatgacc ctgacatatc cagtgtcttc
87721 taccttcctt attgctgtgg ccctttaaaa aaagattagg aatMatctgS catgagaatt
87781 ccacttctgg aatggtggtg agaggagccc catggacaca ttcccctcag aacaaccata
87841 actggtgaaa agtattgaaa agtcaccatc aacaacaatt taaagtctct agaaattatc
87901 ctaagagcac acaacaaact aagcaacatc atctattcaa gaaaatcaac caaatcttgg
87961 gaagaaaaat cccagtaaga acagcaagaa tcggtggcac ctgagccatc acttgctctc
88021 tcttccccgc ttctagtcct tccagttcag cttatgggga gttccactct gggggtgtgt
88081 ggccaagaac acagggctcc ctcttccctc agatcccagt caaggaatac agtatttcac
88141 caggatagat gggccaccag cgtttctcat catctccaac tcccagtgac agagggtaac
88201 tccctgctga gtgtgaccga Raggccggag caccttcctc cacccagccc taactcaggg
88261 caggagctcc gtctcaggtg cagcagggcg agagtgctgg gctcctaatc accctaagtc
88321 cagcctgctt gctagaaaaa tattccatgc tagggggagg caaaccaaga agatcagagg
88381 ctacctcctg cccaatacct ggagtggtgg cttcagtgaa gattctggcg gcaagaattt
88441 aagaggaggc tgacagctct atgagaacaa caacctgaac cacagaccag cttatttact
88501 ggaaaaaaaa aaaaaaatca ggagaacaga tcgttatgag gatctcttcc agggggagaa
88561 tgaatttcaa agactggcct caaaatcatc cctacccaaa tttaattgga tcaaactatg
88621 tgacaattta tgtctcagga cattgttgaa aataatagag caatcatccc tcaattagtg
88681 aagcctagta gctgggtgtg ataccaaatg aagcagagag tgtaacagac agatcagaga
88741 aagggacagt catagggagc cctgctgaaa tcactgtcat cccgggatga ccctgcacac 88801 gctcaaggct gtgccctcca acagctgagg cttcccactg tgaagaatac agactttgtg
88861 aaaacagtct aaccaaatca ggaaacaaat aaatacacaa acaactgcaa acagcctcag
88921 agatggggga ggggaatcag tatgcagagc tgccacatga cccaaaatgt ccagtttcac
88981 acaacagaaa cacaaatgac tcattcacag aaaaaaaggc ggcaacagac actgctggta
89041 agaaagccca gatgtcagat gtaacagctg tcagattttg cagcaaagat ttcaaagcag
89101 ccattggaaa tatgtctttg aaaaaaggaa accatgctta tgtaaaggag tgatgatgac
89161 aatatctcat caaataaaga ctatcaataa agagaaatta taaacaagaa ccaaatggaa
89221 attctggagt tgaaaagcac cataactgag aggcttaaca gtagattgga actggcagaa
89281 gaaagaatct tgaaaacaga tcaatagaca ttatgcaatt tgaaggacac agggaaaaaa
89341 gaatgaagaa aagtaaacgg aacttaagaa aaatgtggaa accataaagg gcatgaacat
89401 atgcacaatg ggagtcccag aaagaggcaa gtgagtataa aggagcagaa aagatggaag
89461 aaacagtggc aaaaagctcc ctaaatttgg tgaaaacatt aacctacgtg tccgagaaac
89521 tcagcaaact tcaaacggga taaatgccaa gagatccaca cccagagaca tcatagtaaa
89581 aatgccgaaa gccaaagaca aagagaaaat tctgaaagca gcaaaagaaa aatgacttgc
89641 cacatatgtg ggaatcccag tgggatttcc agccgacttc taataatgga agccagaagg
89701 cagcagaatg gcatatccaa tgtaaaaaag ctgtcaacca agaatctttc tccagcagaa
89761 ctatttttca aaattaaggt gcaatataga cagtcccaga taagtaaaaa cagagaatta
89821 tgagtagacc cattttatca gacatactaa aggaagttct tcaagctgaa agcaagtgac
89881 ctcagttggt aaettgaatt cacacccaca cacatacagt accagtaaag gtaatcacgc
89941 aactttaaaa gacaatataa atgggtattt cttctctttt cttcccttaa ctggcttaaa
90001 aagcaataat atagaagaag atgtatataa ttgtattatt gggcccatat aatatataaa
90061 tgtaatatat ttgactaaca gcacaaagca ggtgaacaga aacacagcta ctggagtaaa
90121 aaaatgacac cagatgggaa cttgaatcca ccgcaacaaa tgaagagagc cagaaatggt
90181 caacaggaag gcaaactgtt gatatatatg tactctcctc tcttttttca gcttctttaa
90241 gcatgaaatt atataaagca ataattacaa caattgttag gtttgtagca tatatagctg
90301 tgtggtaggc agaactgtgg ccctccaaag atgttcacat tctaatcccc agaacctatc
90361 tatctgtaag gttatatgta aaggaaaatt aacattgtaa atcagatgac tttaaaatat
90421 tgaaattatc ctggattagc cagatgggcc cagtgtaatc acaagggtcc ataKaggggg g0481 aagggggaag cagaagagag aaactggagg gatggctgca cgggaaggac ttggcctgat g0541 gttgctggca taaaagacga aggacagaag tcatgagcca aggaatgcag gtggcctcca
90601 gaaactggaa agggcaagga aacagatcct ccccggagga ggacccagaa ggaacaaaac
90661 cctgccaaaa ccctgattta aactcagtga gactcatttc agactctgac ttccaaaact
90721 gcaaaataat accattgcat tatttaagcc actaaatttg tggtaatttg ttaccgcagc
90781 aatcaaaaac caacacaagt tgcacagcaa gaacagtaca aagatggggg tgggccgggc
90841 gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcaggcg gatcacgagg
90901 tcaggagatc gagaccatcc tggctaacac ggtgaaaccc cgtctctact aaaaatacaa
90961 aaaattagcc gggcgtggta gcgggcgcct gtagtcccag ctactcggga ggctgaggca
91021 ggagaatggc gtgaacccgg gaggcggagc ttgcagtgag ccgagatcgc gccactgcac
91081 tccagcctgg gcgacagagc gagactccgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa
91141 aaaaaaaMaM agatgggggK ggaagaatag agctatataa gagtaatgtt tctatagctc
91201 acaggaatta agttaatata aatctaaaga ttctgataag atgcatacga caagggagag
91261 gacatcacca aagtgacaga atagaggact ccaaaattct gcccctccac aaaaacagga
91321 aataagctag taaatctcag aatcgacttt tttggaactc cagaatttaa ccagaaacct
91381 acaacaacca gggaatgctt aatgaagaaa gcagctactg aattttggtg acagtgggtt
91441 atggtgtttt aatttacttg cttaccatta tcttattctc caactcagca gtggccatga
91501 agatggcaga ccacattcct ggtgtaggtt gctgatacca acctacacat ccaaggagct
91561 caatgactcc cagtttgaaa actcaaaaga aagaaatatg gaccttatat ccagagaatt
91621 gtggttgtgg gttttaaccc atctgctggc ttgcctttgt ttcaactgtc tcggagcttc
91681 cccaggactg aagtggtttc ccagacagtg tttgtcaaaa gtatttaaag gtRaatgtat
91741 tagctgcaga cacctggggc acaggacaat aKttggggca agacRcacaa taaacatatc
91801 taaaggcttg gggaggaaga gggtagggaa ggagatattt gaggaaataa ggtttttgga
91861 aagctcttgt gcataccaga gaatctagga ttctaccact gacatgtcta gggtgagatg
91921 catgctcaga aaaggtctaa gaagactcaa aagttttcac ctctggctga catttagggt
91981 ctgtacaagt aggaagtgaa ggctaagaca gagttgtaaa cagtctggct aagcatcaaa
92041 ggtgtgctca aacacagaac caatctacaa agacgaggag agtatttctt cctaccctgg
92101 cttttaagaa agtctctgtc aaatcactag ctgaccacta agctaacaaa acagagactt
92161 tggtggccat atataatgaa caatgcagac tttacaaaaa tagtttagaa aaatcactaa
92221 acaaacaagc aacaacacat aaaaaacaac aagccccggg aagtgggggg catctgattt
92281 ccagagtctc cacattcaaa atgtccagtt tccaacaaaa aatacaaagc atgcaaaata
92341 acaagaaagg atggtccact cacaggaaat aaaaaagacc ttccctgagg aagcctagac
92401 acctcatgtg ccagacaaag attttaaata aattgtctta aatgtgttca aagaactaaa
92461 agaaaccatg ggcaaataac gtaagtaaag caagaacata atgtatcaca aaatagagaa
92521 tatcaataaa gaaatagaaa ttataaaaag gaaccacaaa caattttgga gctgaaaagc
92581 ataataactg aaataaaaat ttcaatagat cagttcaata gcagatttga gcaggcaaac
92641 aaagaatcag caaacttaca ttatcagcaa tcatcσaatc tgagaagtag aaggaaaaag 92701 aatgaggaaa aaggaacaga acctaagaga tcaagtacac caaaatacaa aaaaatgaga
92761 gttcaagaaa gagaatagag aaacaaaggg gcataaagaa tgtttgaaaa aacaatggct
92821 ccaaattccc caaatttgat aaaaagaaca tgattctaca catccaagga gctcaatgac
92881 tccaagtttg aaaactcaaa gagttacatc aagatacatt gtaatcaaat tgtcaaaaga
92941 caaagacaaa aagagagtct tgaaatccac gagagaggag cagcttgcca catatacaag
93001 ggctctcaat gagcttaaca actgatttgt catcagaaac aataaaggcc agaaaccaac
93061 gggatgacat atttaaggtg ctgaaaaaaa tactgtcctg cggctaaaaa ttccaacaaa
93121 actatccttc aaaaatacaW gaaaaatWag acactttcag agaaacaaaa actgagagag
93181 tttgttttct agttgacctg ccctccaata agtgttaaag aaagtccttc aggttgaaat
93241 aaaaggacag aagacagtaa ctcaaagcca tatgatgaaa tgaagaatac taataaaggg
93301 aaccccaaaa tcttcgtttg taactcttct cttttttcct atatgattta gtctatagat
93361 gcgtaaagca ataattataa atctacatta atagacacac atgtatgaaa tgtaacaata
93421 ttataataaa gggtggggaa gacagagctg tataggagca aagcattttg tatactattg g3481 acactaagtt gatatcaatt caaacaaaat tgttatgtgt ttaagataat agctgtaatt
93541 cccaggataa ccaataagac catagctttt aaatatacag caaaataaat gaaaacatga
93601 atcaaaacag tacactaaaa aacaatgtgt taaacacaaa agaaggaaat atttgaggaa
93661 ttgaggaata aagaatatga catatacaaa acaaatagca gatagcagaa ttcagtccct
93721 ccttatcagt aattatttaa atacagatgg actaaatgct gcaattaaaa ttcagagaat
93781 gggagaatgg attaaaaaat cccaagatat aatccaacta tatgcttatc cacaggggac
93841 caaatttaga ttcaaaatac acaaatagtt tgaaaatgaa aagatggata aagaaatgct
93901 atgcaaatag aaaccagaag agacctggga tggccatact aatatcagac aagatagact
93961 tcaagtccaa aaattttaca acaaagaaca gcattatata ttgatgaaag agtcaatcca
94021 ccaagaagat ataacaatta taaacataaa cacacctaac aacagaatcc caaaatctat
94081 gaagcaaaaa ctgacagaat tgaagatgga aatagaccat tttacaataa tagctgaaga
94141 cttcaatatt ccactttcaa aaatggataa aacaaccggc acatgatcag taagaaaata
94201 gaggacatga acaacactgt aaatcaacta gacctgacag acatacatag agcaccccac
94261 tcaacagcgg cagaatgtgt attcttctca tgtatgatga tcattctcca ggataggtca
94321 tatgttaggt cacaaaacaa gtctcaataa ccttaaagag actgaaacca tacaaagcat
94381 cttctccaac cacagtggaa taaaactaga aatcaatgac agaagaaacc ctttaaaaat
94441 tcacaaatat gtagaaattt aacaatattc tcttaaagaa ccattaggtc aggtaatatg
94501 ttacaagata aattagaata tataataaat aataaatctt gagacaaatg aaaataaaaa
94561 cacaacatac ccaaaactta aaggacatac aaaagcagtg cccagaagaa tatttatagc
94621 ttcaaattcc tacattaaaa ataataaaga tctcaaatca ataacctaac tttacacatg
94681 aaggaaccag aagaaaagca acagaaactc aaagctagca gaaaaaagga aataatcaag
94741 attatagtga aggtagacaa aatagagaat tgaaaaacaa taagaagact caatgaaacc
94801 aaaagctggt tctttgaaag atcaacaaaa ctgacaaaca tttagccaaa ctgaccaaga
94861 taaaaagaga gaaggctcca attactaaaa tcacaaacaa aagtggggac attactaccg
94921 accttataga aataaaaatg attataagag aatattatgt acaattgtat acgaacaaat
94981 taaataacct agaagaaatg gacaaattcc tagcaacaca gaaactacca aaattgactc
95041 aaggagaaat ggaaaatttg tacagatcta taacaagtaa agagcttgaa tcagtcatca
95101 aaaactccca ataaagaaaa acctaggacc agatggcttt actgggaatt ctacctatca
95161 cttaaagaat taatatccat ctttctatga ggccagcatt accctgatac cgaaaccaga
95221 caaaaacatc ataagaaaac tacagactaa tgtctcttat aaatataggt gcaaaaatcc g5281 tcaatgatat tctagcaaac caaattcagc agcatattaa aaggcttata tacaatcacc
95341 aagtgggatt tatccgtgga atgcaagagt ggttcaacac acaaaaatca atccatataa
95401 tacactacat tcataaaatg gaggaaaata aaccacacag tcatcttggt tgatgcagag
95461 aaagcattag acagaaccca acaccctttg tgatcaaaaa atactcaaga aacaaggact
95521 agaagggaaa ttcctcagca tgataaaggg tatttacgaa aagccaaaag tactcatcat
95581 ggtcaactgt aagactggaa gcctgctctc accacctgta ttcaacatag taccggacat
95641 tctagtcaga gcaattcagc aagaaaaaaa taaataaata aaaggcatcc acattgcaaa
95701 ggaagaagta acacttcttg agggaaaatg gggaatgatg gctcgtgggt acagggtttc
95761 ttttgggagc aatgaaaatg atctaaagtt gactgtggtg atggttgcac agctgagtga
95821 atatagtaaa aattatggaa ttatgcgccc gaaacgctga actacagcat atgtgaatta
95881 cagctcaata aacccaccat aaaggaaaga ttaaacaatg atctactcct tacctctgtt
95941 ctcagagcca tttccagccc agcccaggcc ccaggcaacc ctctgtgggt gacgcagcat
96001 tacctgcttt ctggctgtcc agtgttgtgt agcgcaaggc cctgggaggc cactgggttg
96061 gtcatgcggt aaccaagaaR gggagcaagt agttgggtga caaaccctgt acatctgctc
96121 ctaactttcg aaacctggct gatgggaggc caatgtSacc ctctaacgcc ctcccatagc
96181 agcctcggct tgtcttctga cagtggcact gtccacccac aggcatcacg catcctgccc
96241 gcacattgct tccgccagtg gagccccagc tgaaacacta gacaggagag aagtccagag
96301 atcctgctca ctMtagggaa ggagaaagac ctcttcagct tgtcctgcct cggcaaaggc
96361 aaagcctcat gcatttgctc actcctccct cccagggctc agccggcacc tgaagctagt
96421 gtagcagaaa gagcccaatt ctgcatcagg cgggcctggg ttcaaatccc agatcctcca
96481 ctttctaatt gtgccatctc tgagccttcc atcccttacc tagaaacaga gttctttcca
96541 cccatgccct tgtgagacag cgtaagtgaa aatgacatcc acacggtact ggaagcagag 96601 ctgctagaaa cccagccagg cagggtttga acttgttatc tccaaaaagt ctcaggaatc
96661 gtatttctgc ctgatggtga cctacttcag caaggaccca atgtagaaat tactctgcca
96721 ccaaaaaagc aggcctcaga ccccctccat cacctcccYa atttatgaat taaacaacga
96781 ggccagtgcc tgaggggtct gcagatgaga gtcagaaacc agcagccccc caccccacag
96841 agacaggtcc ctgctaacta gacacaagaa ttggccttct ggggtgtctc tgcgtgttct
96901 gtgtatggtg acctagcccc ggccctccag gagggacact acgtgcagga cattttggaa
96g61 aacagtcttg gtgtttcctc aaaaagtgaa acactgtgtt atcatgtgag ccagcaattc g7021 tcctaKgcat atacctaaga gtaatgaaca tatatgtaca cacaaagact tgtccacaaa
97081 tggccatcga ggagaagctg gccacagaga agatggccca gagaggaggt gctgtgtgca
97141 gaagcagctc tgggaggaaa gacgtgcaca ggccaaattc agattactga cacttttttt
97201 ttaatgcaga gattgtctgc agaattacct atttttgact tatcttgaaa aactgaggat
97261 ctggcaacac tgaccccgaa tcttcctaac agcaacaatg atcagaactc agaggttttS
97321 tgtctcactg attttttttt ctttttcttt tctttttttt ttttttttga gatagggtct g7381 gactttgtca cccaggctgg agtgcagtgg tgcactctca gctcactgca acctctacct g7441 cccaggctca agcaattctc ctgcctcagc ctcccaagta gctggttcca caggtgcatg
97501 ccaccacgtg tagctaattt ttagattttt ttggtagaga tggggtttca ccattttgcc
97561 cgggctggtc tcgaacccct gagctcaggt gatccatccg cctcagactc ccaaaatgct
97621 gggattatag gcactttgct gcacctggcc ttgtctcact gatttctgat cttattttgt g7681 attatctttt tccttctatt ttctttggat caatgttgcc tttttctaac tWctcacact
97741 ggaaatttat ctctttaatt tttagacctt tttcttttct aatgtaaatt tccatccacg
97801 ttttgatatt tagtgctttt attatcattg agttgtattt ttgaagttcc actattattt
97861 cttctttgac ccatgaatta tttaaaagta ttttttttta atttccaaat aatggggatt
97921 tttgctttgg gggctattaa tttctctctc acaggcatga tggtcaggga acaagacctg
97981 ctgacactat tcttttagtt tctgtgagat ttgcacttaa ttgaccagtt gttacaagtg
98041 tttcctatgt gcttgagaaa aagaaataac ctctacttgt cagatgcaaa attcatcaat
98101 gtcaagctta ttatttgtgt tatttagaac ttccttatct gtgctgggtt ttttgtctac
98161 ttgatccaac accaattgga aaaaaatggt tggattctct caaaaatgat gataaatttg
98221 tcaatttctc tatttctaac aaagttcacg tcaaatatgt tgaggttatt ttattaagtg
98281 actctacctt tagaactgct ttatcatctt ggggaaatga accttttctc attaaacggt
98341 gacctgtctt tccccagcag cgtctcctgt cttgaggtct gttgagtctg agattgatac g8401 agcaatgtcg gcttgccttt ggcggcctga taggtctgtt tccatacttt actttccact g8461 ttttcttgcc tttacacttt actctggtga tagcgtccag ccagattttg aatttggggt
98521 ttgtctcgtt tgtcagatat gacagcctct gtctttgaat ttgtgagttt aatccattta
98581 catttacctg gattattgat aaatctgggc ttgtttctcc catcttactc tatgatctca g8641 atttgtcttg gtttttctgt ccttttttct cctttataat ttgtcttata aaaaaagaca g8701 tcccggccgg gcScagtggc tcaggcctat aatcccagca ctttgggagg ccaaggtggg
98761 cggatccctt gaggccagga gttcgagacc agcctgacca acagggtgac accccatctc
98821 tacaaaaaat acaaaaaaat tcggggggtg tggtggcaca tgcctgtaat cccagctgct
98881 agggaggctg aggcaggaga atcactggaa cccgagaggc agaggctgca gtgagccgag
98941 atcgagccac tgcactccag cctgggtaac aaagtgagac tccatctcaa aaaaaaaaaa
99001 ggcatccctt tttctctaat ttgtcctgtc accactgtgc tggctgcccc agccaggctg
9g061 caaccctggg gacacacatg cccctccagc agtgagttca gacccttctc accctttggc
99121 ctcaggctcc tcacttcctg ccccctctcc tgagaggtga cacgccatgt ccacaccaac
99181 tccaaatctg atcatcggct ccagtccagt ccctgcacca gctgctcatg ggcctttctc
99241 tctggggtgg ggctgggagc tgtggttcct gctgctgtgt cctgcactac tccacatttc
99301 ccagttcaga ggtgatcgga gccccctcta atatatgcca tcccagggcg gggcagcagg
99361 gcacaaggcc acttcagtgt caacacggat ctcactgcag gaactaggag gggcctccct
99421 taggaagagg cactctggac tgttttaacc acagtcccca cttctccctc ctgtctcaca
99481 gtcccgagct tcatacacac acgctgctgc ctattctgga attatgcagt attattattt
99541 tatattcatg tcgctgggca tatgatgctc ccatgacaag gggccctgga gcttttagat
99601 caatccttag aaggactcca gccagacccc aaaggccaca tattatcaat tgggtttcta
99661 tgaagtatac agaataggca aatccaaaga cacagggagt agattaKtgg tcactatgag
99721 ctgggaaggg gaatggggag tgactgctct gggtgcaggg ttcccactgg ggtgatgaaa
99781 acattttgga actagatggt gatgatggct gcacaacact gccaaaaacc actggattac
9g841 acactttcat actcatatgt attatagtcc attgattttt aaaaggtcag aggaagcaac g9901 tcaaatgctt gtaggaggtc agaagaggcc cagatgggtg aagtcggggg ggcgtgcaSa
99961 ttaagcccac aagaatattc tctaagctac caggtcacac acacactcYc tctcactgtS
100021 cctgaagccc atagccccct ctgcctgact ctcctatcaa ctgtKgatgg cgtcaaagat
100081 gcacaSaaat atattttggc tgaaagaaac acaacagggc acaatgagga agggctgcca
100141 agcagcctat tagcagcatt tgtcatggtt catctgggag tctgcctttt cccccagcca
100201 gactcttcag ggacagagac cagattgttc atactcagtg cccagcaggg cgctggcctg
100261 gggtgcttgc agacactgac tggatgaatg gatggatgga ttgggtggat gaatgagtgt
100321 gtagatgaat ggatgatgaa tgatggatgg atggatggat gatggatgaa tgaatggata
100381 aataattgga tggatggatg ggtagatggg ggatgggtag atggatgagt aagtagatga
100441 atggagatca atgatggatg gatagatgga tggatgaatg agtgggtaga cgaatgaata 100501 cacgatggat gaatgaatgg ataaatgatt ggatagatga atggatggac ggatgacaga
100561 tggataaatg gatgaatgat tggatagatg gatgaatggg tagacagaaa gactctgata
100621 ctggaaagtg aatccttcac atccatggca agtgaaccgg gtaacaaagt cagaggcaag
100681 accatagcag cgtcatttgt cactgttgcc atttatacac atttttgggg cagaatcggt
100741 catgcttgac cacaggtcat ctctagaggg tgaggattgg gggtcaggaa ctgtggggtg
100801 ggctcagggc tagggctgcc gatgtggcct ttgtgcctgt gagcagactg catttccatc
100861 agcctcatcc ccatcttccc tctctgcctc caccagtgag ttcagatcct tcctacaatt
100921 caatcttggg gtcccctcac tttctgtccc atctcccaag acctggctgg ggcctgactc
100981 agaatggggt cagcaaagcc ctgaggtaga gccgtctccc aagattatgg cctggctggg
101041 gcccgcctca cctccattca aaggacacca tgtggaaaac caatgtgccc ccaagcaggg
101101 gtggcacggc acagacactg atggcacagg ggccacttct tgctccttcc tggtgtcttc
101161 atcctcgggg atcaggggct ctgcagcagc aggcagggct gggcagccct ggagtgtgtg
101221 acacaattcg ggcactgtga ccctactgga cccctttgca cagatgctgS tgggcMtagg
101281 aactggctgc tccccactgg ctgctctggt aggccctggg gtctgcctac acccccaaca
101341 catgagcatg ggcaggtacc caccagtctc YttctStgtc cccagcctct cccgcagctt
101401 ggccttggtc caccgtggac agcgtctctg acacggtcYt tcttcccaca gggagaccgg
101461 gagggtcttg ttctgccctc agagcagagg ccccaggctc cttcaggtgg gagcacaggt
101521 gcctttcgca cagggcccag cagccagctc agcccacaga acagtaagcc gccaggtccc
101581 aagttgtcat cttgtgaccc gcccctgggg acacgggtgc ccaacaggaa agaggacggg
101641 ggcttattat aaggaaaata gtgtcaggcc tgccatggag ctttgggcct gaggcctcag
101701 ctgaggccaa ggcagcagga ctcatccaga gacaggacag accctgggct cctggtgccc
101761 agctcaggga agctcctggg tgcggctcgg ttcactccag catttcctac atggatgaaR
101821 atgtggatgt gtctgctctg accatgggtg tgtgcatgcc tgcgtgtgtg tgagagagag
101881 agaggagaga gagacggaga gagtttatgt acgtgtaact accaaccaga gtccaggagt
101941 ctcacactcc actgcaaacc aggcaggcgg ggccagcatg agtggggggg ccaggcacga
102001 atcggcaggg agggaggggt tgtgttcgcc catccagagg aggcacagag cctcccaccc
102061 agtgctgctg gcaggaacac gcccagggtg gccaggcctt ctgaaggaac tgaaaattga
102121 gattttcatg tgaaacctcc tgatttttaa gtgtacactc aacatttctg aagccgttgt
102181 acgagtcaaa taaaacattg cggggtgggg cggcgaggcc gcccaagagc tgcagggctg
102241 aggcctggct ttagtccagc accccgatgt acatacagac gagaagactg aggtcaggcc
102301 agagcaagga ctccgcaggc caggcccaca ctggcggccc cggctgcctg gcccatcact
102361 ggggtcacca cagcccatgg ggagcaccaa gSacaccaag aaagggaggc ccaggcctgg
102421 tccccggggt ctctgtcacc aagggcccac attgtgagtt tcaaaggtgg ccgaggtggt
102481 tcctacaggc ctgtgagtcc cσacactcct tcccagttca aggcctcggg acaaatccaa
102541 gcccagcttt gtcctcgtgg tgatgaaggc caagaatgct gggagctccc gggatattgc
102601 cYaKaacaaa ggagcacagg cacctgacgt tctggacaca agggcagaac cctcttgaga
102661 ccatcatcgg ccgtttgctc tccaggctgc gggggcctgg aggacatcca ggcacgggta
102721 taggtgccgg gagcccgggg aacagaacct cagacccgga actgggcacc agatgcacca
102781 gccgggggtc tgtccgccca gcccggggag tccaggggct gctccgaacc cggcgccacg
102841 cctgctccct cagtgccgca tccaacagct ctgtctgcct gggctggggc cctgcRccct
102901 ccccgctgct ggctcccgct gatgcgctac agatgggctt catcgctgcc tccaagaaca
102961 acaggacgac cgcaggtttc gcctcacaga aacggaaccg ctggaaaggc ctctcttgac
103021 attcccgaaa ggaaaataaa aattcctctg aagtacattt caactccgag gcagccctgg
103081 ccacatccaa gaagctcggt cctgagcgcc gtgggctcca gtgaaggtcc ccagcactga
103141 ggccgcctcc tgacccccat cccggccact gccccgggct gctcaaccct tacacggctt
103201 tcacaaattt tgaattagct gσcaacagtt taaaatgaag agattgtaag taaaatcaat
103261 ttccagcttc tcttataaaa ttggaggccc tcctgctgct ggccgacccc gtgtctacct
103321 gggcccagtg atctctgctg gcgtcacctg ccaggccccc atcagtgtgc ccatacgaga
103381 ccactgtcct cagcgaacgc ctgaccccca ggctccaggc aaggttgaga ggacagatgc
103441 tctcatcctg ggggctctgg ccttcctggg gccagtgtta tccagctctg ccctccagag
103501 ccctctgcac acgctggggc tgggactgcc catggctgtg ggctctgatt tgggtgggca
103561 gacctgagca ggccatcatg cttcttattc ccagcctgac acccccagac cgccccccgc
103621 caacccagac aatgtgtact gaactcctcg tcaacttgac ccctgagctc ctccccgcag
103681 cccaccaggt gctcctgctg tggtttgggc agcacctagt ccttttcgcc ctgctggacg
103741 tcgcctggcc agacttgcag agccatctca gccctttgtt ctcctgactc catccctcca
103801 agcctggcca ccccagcctc ggccccagct cctgccacgt gaattgtcaa aggcagagca
103861 tgaggaggct gaaggcagcc cccatggcac accccacgga gtccctgcag tcgtccaaaa
103921 aaggctcaag cctgggcagc attgctcgca gctaggaatc tgcagctgga ctcaaatatg
103981 tgtccagaat gatctgggaa aggtccttga gaaaagggcc agacacaggg accttcccag
104041 gcccggatcc cacagaggaa atgattctag cgagcgccac ctcgacaggt ctgaggtcca
104101 gacaggggtg gagctgtcac aggcagccgg gtggggctgt gatctgggtc ctcccagcct
104161 cacggtgatt tggaatggga atacggttct gccaggcaag gagtatcccc ctctgaccaa
104221 cctgtggact gcctaccagg actcccaaca cccttcctgc acgatggcgc tgaggggctg
104281 atccggccgc tgctctcatt cccatggcca cctgatccag gccgcagtct ctccctgcac
104341 acaggacagc agcctcctgc cggctccctg cctcttccgt gctcaccctc ctcggaaacc 104401 agaccatgcc acctgctgca tggcacagcc cctcctccac gacggagccc acagaagcca
104461 tcgtgatctg acctccagtc ccctcaggcc ctcaccctgc ccctcctgcc acacccccaa
104521 acaagccccg tcctcacccc tcaggtactt cgcatctgct gccctggccc cttttcctcc
104581 tggggaactg caacccacac tccaggcctc agcccaacgt ccagtgactg cgggctcact
104641 ctgtggcact tcccaagtct ttcattgtgc aggtatttgt ggactgacta gtgcactgtg
104701 ggctgtatga ggtcagggct gtgcctgtct ggtcccagag cctggcccag tgcccggtcc
104761 tgctgtgcgt gccgggtaaa gatctgttgg atgaatcaag ggagagagga aggggagcag
104821 ccctgggatt ccacaggtgc tttatgtcca gagacaaccg cgcagggaac agtggccaag
104881 gcacgctggg agcagtgctc cagcccgacg gcatccccag ggcagaggct gggattcacg
104941 cattgctgcc ctcaggcacc aaacgggcct gtggcagtca caggggcaca ttcctgatac
105001 cgggtctgtc gttccagcat ggacagggcc atcttcctcg ccatctgcag tctggcatca
105061 gacattccca aataaaggac agacagttaa ctgtcagaaa gtgctggtgc ttgggcctgg
105121 aaggaaggga gcccgtgtct actgggcacc cccaattttg gccactgtgc agtgccctgt
105181 gtcctcaacc tcggggcctg gaccacagct ccatgagacc acagggagga agcagagtca
105241 cagaagaaag agtgatgaac agcactggcc acttgatttg cagggcacag tgcaaaatgg
105301 aaacgcacag tcccttgttc aaaaagtgat tacgacttct aaggcaggaa tgacagagtg
105361 ttaaagtggg catagggccc tgccggatgg gtcacaagcc ggcgaagtca gtcctgctca
105421 agtgtgagga agtgggacta gcaaaggccc agggccaccc aatgtcccat gggcccatgg
105481 gaccagtagc cacccacagc tgccaacctg agtctgcagc cctgacactg tggcaacaac
105541 aggaggcgtc agtgccaagc cctccaatgc ctgcagggag caactgttgc tcccggagtg
105601 agctcctggg cgaccgggct tcctaggcac tatgcttatt ctttcttttc acggatattt
105661 acgcaccaac cgtgtgccag gcattcctca aaatgctgca aattccactg taagcaaaag
105721 attctccccg aagctaacgt gctaagtgac ctggagacac atcctcactc accctcgctg
105781 ggccccagtt tctgcagccg ttaagtggag ttccaggcct tggtgcttgg aaggccctct
105841 gtccaacaaa cagatggggt cacaggctac cgggttttgc cagcccaggc tctgagcggg
105901 gacaggaggg cactgcactg ggtgtcagca gccctgggtt ctaagcctgc tcctccctcc
105961 tgatgcagga gtcaaaaggc ctggctccca ctgtttctac agcttactat ctgtgcaacc
106021 gtcggcacct cagtttcctc atctgtaacg tgggcacagc aaaagcacca acccaccgtg
106081 gggctcatta caagaatcct aggagatgat gtacctgcag cgtgctggca gacgcggtca
106141 acggtaagtg ctccaggaac gcgtcacgtt cttcttgctc cctgctgttc ccgctactgc
106201 ttggacagtg gtagccctgc accttagttt tctctctgct tccaggacta ccgtgcctat
106261 taaatgacac catgaagagt gcccaccttc gcgcaggccc tcggtgaatg ggcatgtcct
106321 tgaacgcaaa cttggctcca acggggcagg agaaggatca ttcagactca gctacagaaa
106381 aacagacttt tgtgcaacta acgctaacaa aactggaaag gaaagaggaa ctacggcctg
106441 gggaaaagct tgtatcgaac atgacagaaa gtcaatatct aaaaagagat aaagggctta
106501 tcccaatata taagacccca ggagataaac aggcaaagga cttaggaata ggagacatgc
106561 agagtaatca aacccaggga agatcactca tcctcgccag taaccaaaga agcgcaaatt
106621 agcgcaaaaa gcaacgccgc tttgctgccg gagcagcaaa atattaaaca ctaaagcccc
106681 cgtgctggtg aggatttgga gaaaccagga gctgctgtgg gagccagtct ggctctgccc
106741 cgagtggtga gtctgttaag cgctgggatt tcctaattca tttagtcact cagtaggtgc
106801 cccctgatgg ctgctcaggg ccagggctcg agcgcgtctg ggctggctca ggccgccatc
106861 tgccgggtca gcaacagata cctatttgca ggaacagaac ctgaggtcag ctcccaggat
106921 gtccccaccc ctgagtttca agagagtttg caccaggagc agggagcatt ccagctgtct
106981 cgggcagctt ttgtgtgggg aacagctggt agcgctgcct gcggcccctt ggggtggaca
107041 ggaaggctct gcctgcaaag gcctagaggc agccacacac cctgccctgc acactcctaa
107101 gtacgtgcag gccacagttc ctgcatccat tcatcccggc cagtctgggg tccctcccca
107161 cagtggcagg caaggggaag ctggaccggt cctgctagaσ aaacaaggat gcacacacgt
107221 ccatgggacc ccaaacctca cactgtccct gacagcccgc cccacagagc acagcctctg
107281 cctcccggag caagaggagg tggcagtgca tcccagggcc tggctgcctg tggggctgca
107341 ttgggggctc ctgcccccgc cccgtgagtc tgggaacaca tgggtcttgg ccttggcacc
107401 ttctttcctg ggaaaacacc tccctctggg ccagggcagt gcagagcagt ggaagcgggc
107461 agctgtggag tcagagtgat gggtgccaat tctgactcct gcacgtggcc cagaccacct
107521 aacctgccac ccccaccagc acacctgccc ggccaccccc accagcacac ctgcccggcc
107581 agcctcaggc caccagccag cctcccagcc acgtgacctc tcaggggcag gatgtgtcct
107641 tgattccttc cttcacacca cgtcccggaa gctccacctc aaactcatcc tgaacccact
107701 gcctccaccg ccatctgtca ccgggactcc tccctgcttc cacgccgtcc accgaaaacc
107761 ctccaaaggc ctccaccgca cagggaatga attctcaccc cgtaccgtga ccgtcccttc
107821 aaagcgatga gtgccaccca tccctcccgg ccctgcacgc ctcccactcc cccattacgt
107881 cctcagttcc aggtactagc tcttccttct gccccttggt cacgctgcgg taactccagc
107941 ctcagggctc ctgcatgtgc tgttccctct gcctggaaca cccttcccag ggctgggctt
108001 tcccatcatc accaacctgg ggcgcctccc tcccttacct gccttctcac gctgcccttt
108061 caccccgttt tactttgttc acaggattct ccactgtctg cgagcatctg ctcaccaggt
108121 ctcccctgcg gggctgtgag cccagagaac agggactcga tcgggttcct ccgctgctac
108181 agccccagca cccagtcctg tcagacacat ggtggacaca tagcaagaac gtgacgagtg
108241 aatgcaggaa aatacacttg tggcagcagg caaggtgccc tctctgagcc tcagtctσcc 108301 cctaagcagt agagctgcta atgctattat tcccccatga tttggggagc agtattattc
108361 ccccatgatt tggggagcag tattattccc ccatgatttg gggagcagca ttattccccc
108421 atgatttggg gagcagcatt attcccccat gatttgggga gcagcattat tccatgattt
108481 ggggagcagc attattcccc catgatttgg ggagcagcat tattccccca tgatttgggg
108541 agcagcatta ttcccccatg atttggggag cagcattatt cccccatgat ttggggagca
108601 gcattattcc cccatgattt ggggagcagc attattcccc catgatttgg ggagcagcat
108661 tattccccca tgatttgggg agcagtatta ttcccccatg atttggggag cagcattatt
108721 ccatgatttg gggagcagca ttattccccc atgatttggg gagcagcatt attattgagc
108781 attaatgaac ccgcatggca ttcaggtgcc cggccttttc ccaaccagac cagcgcacca
108841 gccacctctc cacacaggcc cagtgcccag gtcacctcct gtcctgtcct gcaggctctc
108901 tctgggtgtg ccgacagttt gggatgggag gcgtgggagg cgtgagctgc gctcctggcc
108961 gggttctcta ccagctgtgc tcgtggcgca gcccacacct cacggcaagc cccagccaaa
109021 gggaccaagt caagagctct gagagacatc ccagccgaag aatccagccc ttgtcccaaa
109081 cgtgtgtatg cacaggcaca cgaaagaagg tgagacagaa ggagagaaaa atgaagccag
109141 agagcaggag agagagaaga cagacgccag cacgcccatc tgactgcgcg acctttcccc
109201 gctcagagct ccttcagggc ccagagcaca gcgctgccta ggattaattt caaagagaaa
109261 cgggtcaaag aaaattggaa atttttatag aaaatatttc aggcttggag ctggctgaag
109321 tgtctgccaa cctgcagaga attctgagag gagatggggc ctgtggtcag aggcctccgg
109381 ctggcacaaa ctggcagagt ttggacctcg gacccaaatg cagtttctga gccaggcctg
109441 tcctcgctgc tgctggggaa gagcttcctg tccccttcag atgtccctac agctgcctct
109501 gcagccctga tgctggtacc caacgcctct cacctgtcgc cccacccctc tctatcccca
109561 agaggcctct gtctagggac ccactatggg atgcagtccc tttgtcccca ttatgcaggg
109621 tgcccatgtc tctttcaccg tcatccatgg ggcagccagg gcatgaagga agcctcacct
109681 gggtcccaag caggtcccac tgctccttgc ccaaacttca ccccagccag caggctccta
109741 catccaaggc acagatgtca cagacatgaa aagatgccct ggacacatgc ctctctccca
109801 gaagcctgcc tctgccatgc tggggacctg aaaagagggg gcatgcccag cccacagttg
109861 ctgatcaaac gccagatgcc cccgtgagca gatcacagct tcacccctga gccgtgtact
109921 gtctgcatgc cagggactgt taccttgtgc aaaacccgaa aagctctttg gaggacattc
109981 ccaacacaga tccaagggaa ggaaagaaag tatcaattca ctgtgtctgt ggaagatggc 110041 gaggcagagg agggaaaggg gacggagagc aagtgtcgca gtgagcactg ggcaggcgcc 11O101 ctgtgccctg cgtaattcca gcagcccctg tgccactgca cccaggtaca gtggagatct 110161 cagcacccag gttctgagat cctgaggggc tgggtgagct gctctgggcc ccttagtgag 110221 ccagaacaac agcatgtcgg gtggagctga gcacactgac ccctgcacca acagcagcat 110281 gctgggcgga gctgagcgcg ctgacccctg caccagcgct gacccctgca ccaacagcag 110341 catgccgggc ggggctgagc acactgaccc ctgcaccaac agcagcatgc cgggtggagc 110401 tgagcacact gacccctgca ccaacagcag catgccgggt ggggctgagc acactgaacc 110461 ctgcaccaaa ctgcccgctg cccaccccac tcacccacct agtgctggaa gcatctgtgg 110521 gagcagccct aatgcagctc ctcagaacca ctggccggtc ttccagaact gtcccctgca 110581 ctcgagttgg ggctgcagcc aagccagggc caaggccacc atcctccggg tcaggcttgt
11 O641 cacctgccca cggtgctcca ccaaagatcc aggcccttgc cagccacatt tacctggtcg 11O701 gctccacccc tgaaccagaa accatgtcgg gaggggagag gtggcggggg aagggcaagc 110761 ctgagactca gggactaaat ttatgtcgga ggcacagggg agttgctgcg cacgtggggg 110821 ctgtcaggcg gagtgccagg cccagacgcc gtggaggggg agcacaccct ggcacgtctc 110881 cactgtggaa taaggggggc ccagccctcg ctggggctgc aagcctcgct tctgccttca 110941 cagcccaggg ggtgggaagc acccacaggg cagcgctctg agcagcagac tccagccaga 111001 gagccagcca ggcccgggag ctggcccctc ctgctctccc cggctgaccc caggcaactc 111061 cagcctcgga gaatgtgcag cctcggcttt cccagcgccg gcccccgccc accccttccg 111121 cgtgggccac atcaccgcgc tggcatctcc aacagccatc ccaagggccc ggtctgcacg 111181 aggacaggag cgccgcggcg tctgccaagg gtgcgctcag ccctgaagca cgcctcccgg 111241 agccgcctcg ggtttcacaa tcagtgcttc tccctgggtt tcccggggcc tgggctgcag 111301 gctcagctcc agggtggaaa gagaggatga gctgagagga ctccagggat ccagcgccga 111361 ggcgctgaac tcagtgagtc ggcaacagtg gcttggcagg gcccaggctg accagggtat 111421 gagagagagc acctatcacc acgccagagg ccctggcctc aggggtctgg ggagtcactt 111481 gggaagtgcc cggttggaga cacagagaca ggtctgggca caagacgctg gccaggtcca 111541 gggctcaccc tgcaaatcca gccaaagccc tctctccatt ctcccttagg acccaaggtt 111601 caacacttag acatgtcagc tgaatcatga cccccggacg tccatgtcct aatcccccaa 111661 aactcgtgag cattacctta tatggcagaa gagactttgc aaatgtgttt aaatcagggg 111721 tcttgagatg gggaaagtaa cctggatggt cccagcgggc cctaaatgtt atcacaagtg 111781 tccttctaag agggagagct ggctatagaa gaggagaagc cacgtgacca gggaggcaga 111841 gactgcagca atgttgccac aagccaagga acgccaacag cccccaggag ctgggagggg 111901 ccaggaatgg attctgccct ggggcctccc gaaggaacca gccctgccag caccttgatc 111961 ttagccccta aaatcctatt tcagagttct gagctcccga actgtgagga atgcaggtgt 112021 gctgttttaa gccattaagg tgtgggtaac ctggtacagc agccacagga agctgagatg 112081 gacgtcgaca gctacagggc agaaaggctc tctgacctgg cattcagcaa attggcaccc 112141 cccaacaaag cacacggccc tcctgcccca tcctgggccc cccagccccc acctgggcca 112201 agcctcacat ccgctgtgtc agtggggctg gctatctgct cgccactgaa tggatgagtc 112261 tcgcctgctc cccagtcctg tggtctgaca gaacagagct cctctctctc tcctgtgcca 112321 ttgctccagc ctcccccacc agcctccctc acactgcaac cagtacgagc ttgctgaaac 112381 actcaactct ttgtgagact ggagggcgcc atccccacct tgggtcattc aaggctgctg 112441 cttccatgga ggctgcccca cagctctctg cctccagccc tgggctctgc acacccaggg 112501 ggaactgtca tgcctgaggt ccgcccccac ccccgccgcσ cactcttccc ccaggatccc 112561 ctgcggcctg gaaaactcct acccaactca aggcaaagtσ acagggtgga gactgtgggt 112621 caggaggggc tcttcctggc ctggtgggga agggctggct gtgggctgca ggtggcagcc 112681 acgctcagcc acatggagga gctgcccagt gccggcgctt gtcctctgtc tcctggaggg 112741 ccttccttgg tgcagcgagg ctgagaggct cccgtggtgg cgtgcctcgt ctgcccgtca 112801 gggaggatgc tgcagcctga cagcagcagg cagaggcttg gcaccggcgg tgtctggggt 112861 ggaggcagcc aaggtcactg gcacgttgct gtctgacttc tcttccttca gcccagcagg 112921 gtgtgtgcac agcagcctgg tagcagttcc ccaggatggg aagcacctgc ccctcctctg 112981 tcccaaggcc aggccggggc gagccccagg agagcagccc acagaggagg gcagaagatg 113041 cttctacctc tgcatcacag aaagcatggg tagccaatgg gggaccgtgt tttgtttggt 113101 ctatatagtg agcacgggag gggaccccag gcatgacagc tcccactggg tgtgcagggc 113161 ccagggctgg aggcagagag ctgatgtgga ggcttctgtg gaaagagggc tttgtctgga 113221 tttgctggct gagccctgga cctggccagc gtccttgtgc caggacctgt ctctgtgtct 113281 ccaaccaggc acttcctgag tgactcccca gacccctgag gcctggtcct ttcgcatggt 113341 gataggggct gtctctcgta cccgggtcgg cctgggccct gccaagccag ctgttgccga 113401 ctcactgagc tcagcgccgt ggctggattc ctggagcctt ctcagttcat cctctcattc 113461 cagaaatttt aagccacatt ttaacatcag gaaagttcac ataaaaagtc tgatgtctgg 113521 attttcttga taggatgttc agctgcacca gacccaactt ctaccaaatt gaggtcaagg 113581 gagttgagga gggtctgtcc ctccttgcag ggcctcccag acgccctgtg cccatggcaa 113641 ggccagggct ggacaccacg tgtggctgca ttcccactgc tgtttctttt tagtggagat 113701 gtattcttgg tctccacgtt tccatcaaaa ggagagaaat gaaagccagg ccaagggtgg 113761 gtgcaattat ctttttttcc tccactgctg tccttgttgg cattgcctgc caggccctgc 113821 aggctctgag tttgcagctc ttgtctttct gcaaatggca ctgtgtgtct gaaacagaga 113881 ccacatgctc aacacgtgac tcggggtctt tctcactgtg tggcaacctt cacagagtcc 113941 caaggtcagt ctctgggaag ctaagacagg ccctcagtgt cagcacaggg ttggcttctc 114001 tgtgcacgtg gtcttggagt cagccgctcc aggtccctta acgcgggcgg tgggggagga 114061 ctgccaggct gagactggca cttagacatg cagggaagag ctcccacacg acagggtgga 114121 gggtccagtg agggaggcag caggaccagg gcctgcctgg gctgtgcctc tgggctatat 114181 gccctgggga ggcgtaagtg aagcctacag tgctgctcct ccgcgtgacc cagacgggcg 114241 cctcccgggt gtgctgtgca ctgcgtggcc agccttgtac gtgagggcca ttcacatcct 114301 gtagctggct gcgtggtgcc cccaaagatg ctggatcctg atccctgcaa cctgagacgg 114361 gtaccttcta tgggaagaaa gggctttgca gatgtgcttg cagtaaggct cttgagatga 114421 gaagcctgtc ctggattact cgggtgagtc ctaaatgtaa tcaaggcatc cttgcaagag 114481 ggaagcacag ggacacgtca gaagaggagg gggcgacatg atccgggggc agagattggc 114541 atgatgcagc cacaagccaa gggaggctgg cagcccccag gagcggggat gggccagaaa 114601 cagattctcc cctggagcct ctggagggag cacagccctg tccacccttg atcttggctc 114661 agtgagattc atttcagact tctggcccac agagctgtga gagaggcatt tgtattagtc 114721 cgttttcaca atgctgataa agacataccc gagactgggc aacttacaaa agaaagaggt 114781 ttattggact tacagttcca cgtggctggg gaggcctcac atcatggcag aagatgaaag 114841 gcacgtctca catggcagca gccgagagag agagagcttg tgcagggcaa ctcccgtttt 114901 taaaaccctc agatctcgtg agacccactc accatcatga gaacagcatg ggaaagaccc 114961 acccccatga ttcaatcatc tctcactggg tccctcccat aacacatggg aattatggga 115021 gctacaagat gagattcagg tggagacaca gagacaaacc atatcaatgt tcctattgtt 115081 tcaagctccg tgaggactcc ctcctcaaca gtcccacaca ggatgagatg cacacacacc 115141 agagaggaca atgccacagg gtgccctgtc cctgtaccσc agcacagtgt ccctggacac 115201 agagctggcc ttgggaaggg cagagaacag ggattggaga tgcctgtcag aatgcctggg 115261 gggacacctc aaccactgct ccccaaaagg ccacccagcc tcagagctcg gcctccggtc 115321 ctggccaggt tcccaggcca gcagcactga gcaggaccc t tctgccaagg ccagcatggc 115381 cagggaggag agaaaaggac cctccccgct ccctcacccc ttgcccctcc taataacatc 115441 ctctcccggg tgttgcctaa gctgcccagt gcacacact c atccctggcc tgtctgtgaa 115501 atgctttaaa accgtcattt tctatccgtt tcccccaggc aatctgcaat ccagcaactg 115561 atcttggatg acagagacta ttagtgaaaa tgattccctg aggctccatg agtccccgag 115621 atcaccctga gcagcccgtg ggcttctcgg ggaaaacagg acatcctgaa aaggaggcac 115681 ccctgacgct gcagggatat cctgccaccc agacagatgc ccacccccca ctgggacacc 115741 cagggcaggt gtgtcacctt ccccggcaga acataaatag cagggtgctt cacacccact 115801 tccagacgtt gcttttgggg aggcaggaag aaactgccag ccagcacctc ctgccagctt 115861 ctgccagggc cacactgata tatcagggtt ccctcagaat tcactggaag aaagggtccc 115921 ctatacacac acacacatac acacacaccc gcacccaggt cctggagttg tgtgccaggc 115981 aggctgtgcc cctcactatg cctggccaca ggacacagct tttatgtatc tcccagttgc 116041 cactctgggc cctgaaaagg cccaggcaga tggaaagctg gacgcctgag gtcaccgtgg 116101 gccctccacc cagctccggc actcactggg cctggtgccc ttccagtcag tgtgtcgatc
116161 tcagcccagg gccacgtggg aacgattagg tgcatggcgt gggagctagc tcactgaagg
116221 cccgagcccc tcatgcaggg tctgctgaca ccagacagga acatcaagca aaggggactt
116281 ggccccagcc ccaagttctg ggatccagac ctatagcccc aggcccacgc tcacatccac
116341 agcctgggcc ccaggcctgg agctaaggct ggacaggctc acctcctccc cgacagccca
116401 ttaccaaacc cccaccttcc agcccagcct cacccctgac σtggcagctg gcctcaccca
116461 gcgtcttcta aggccaatgg tttctgggct tattctgaga ttgaaattcc tttcctgtgt
116521 tctgaatttc aagttctcat taaagatatg tggattgggg gtgggggtgg agggaggatt
116581 cagcagaaga tgccaaacac cagcagaagc ccagaaaata aggcaaggcc ggccaggctg
116641 tgggggaagg gctgccatgt tcaggaagac aagcaccata tggaatctgg gatcagagac
116701 atggccaagg gcacgtggcc agctcacctc acctgagcag aggcccccag aaccaccctg
116761 aatcttccag gagaggccag ccagaagcac caagcccaca gcacaagtga ccagcccctg
116821 agctctcggg gacacagggg ttgctaatgc cactgggctt gcccgacagc agctagctag
116881 caaggagcaa agctggggcc ctgcccccgg gtctggagca ctcgctcagc cccttccacg
116941 ctggccctcc tagattactc ctccttcctt ccctgcaaaa tagtccaagg gtggggataa
117001 gtcgaggctg agaccacagc tggaaaaggc tgggcaggca gtacccagtg gcccggctgt 117061 ctgcagcata gcagacgctg atttgtcacc aaggaacaag gggccaccgg ttgcactgat 117121 tggctccaga gtacattggg cttcctgatg gaacaattcc tttgcaaagg tatctgatgc 117181 cgtttcatga aattagaagt atgcctgcca ggctgtaccc aatttttctg tcaagctagg 117241 aagtcagaca gacctacagt aaatgaggcg gggctgctat ggagtgacgg gagtacctta 117301 gtaaatcaca gcacgggggc tggcccagcc caggcccctg gagcactcgc tgtgaacgtg 117361 caggtgtgcc cgatcctggg ccccagactc cagactctcc tcacccaggg gtcctgacca 117421 gaggctgagg gctgagctcg cagcttccca ctctcccagc aagagccaag cacaggccag 117481 gagtccctga ccacacgggg gaccctgaga actatgggcc tgcagaacca catcagacac 117541 caaccctggc ttcaccacaa tccaggacca gagactgggg gatgctggga ggtgtgggct 117601 ggcacagtga ggccagatct gaggcgacag tcatggactg tcaccatggc cgcctggcag 117661 ctcctttcac gtttctgggc ccagggcaca cgtgggttct gagttgaaaa agacagacgc 117721 ccatgagtct gtgcagagac tgctgaggct gctgggagca cctccagagt ccttgtaggg 117781 cacatgcctc cagggatcca gaaagagcat gcagggcctt tctccctgag cagccaggtg 117841 agggttggga cctaccacag gcaccctccc agggaccatg gcagcacaga gcaggagagg 117901 cgctgtctgg ggctctggag gcctcttcac aggcacagac tcagagacgc aggcactgga
117961 ctcaggcctg gccgggggcc cccgccccgc tccacgacac ttgcttgcct ttaggcaaca
118021 gaagatgggc ccttggacag ccttcatagt ccaccatgga ggccccagac atgaaggcag 118081 aggtgtctgg gctgcttgtc acccacatgc acccagaaca gaggccccag ccccagcagc 118141 cctgctacgc cctgccgtca gccaggcagc tggcccattt ctgagccact gagaccgggg 118201 ctcagcctca gcagccaagc tggtctgtgg agagctgcct gagtctctgg gatgctcccc 118261 tggggaccag ggcctcagag ggctctccac acagcctgcc cacctgcagt agcctcacct 118321 gtgtccaggg cctgtggccc cccgagagga ggggacgtgg gtggccggcg atacaccaca 118381 tgcacacggc cttgctcagc ctcctgcgcc gccagcccct tctccaaggg ttcgatgaag 118441 aactcctcct cctccatccg gatcagacca gcctgcggga caaagacaac aggatcagat 118501 ttccagcaca caaaagacca aggaagggga acagσgagga gaccccctca gggagtacct 118561 cccacctgaa gaccctgccc agcaccccag ctggtgctca gcttgaaccc tgggctggcc 118621 ggagggtatg aacatgtggt cccagaggcc gccccccgcc gcccaccctg tctaggaaag 118681 gggcctctgt ctgggtcatc tccaccccta tacaccaacc ctgtctgctt tcagaaaagt 118741 tactgtgttt ataaagtcaa aaccgtccag agaagcaggg agacattcaa gggcagctgt 118801 gggcctgtgc gtgtccccag gagggcatcc accaaagtgc atcaatatgg gccaagtgct 118861 gcccccactc ccaggagccc agagtccaag acaaaggtca aaacagccag ccggggattg 118921 aatctgccca cacacatgtt ccatctgggc caaacaatat ttttaaagct ctgaagctaa
118981 cactcagaat gatgagattt catgtcttga acatggaatc ccagctttcc ttggaaacgc
119041 aggccctgac cacagcgggt cttggatgga acacatgccc ctgcaactgg ctccagtccc 119101 tactgccccc caactgtctc tcctgctctc tgtgtcagcc accagcccag actctacagg 119161 cagctgaact gctgcccctg accccctagg ccagccagca ccctccctga ctacaaactc 119221 ctcgctgggt cctcatttcc gttgggactc aggctgctct atatgctggc attcaggctc 119281 ttggcctgcc ccaccctccc agaccgcggc ttgcaccacc ccatgcttct cactgggctg 119341 ggtgcaccct gccgagccac ccagcccctg aaccccatgc tgccaactca ggaatcccca 119401 ttctcccacc ccaccacccc atccccagct cggccatctg gtaaacctgt gttccccctt 119461 cgaggcctga ttcagacccc ctcacctctc ctgccctccc ctgccatcca gcctgccctc 119521 ccctgccata ccctgccctc ccctgccata ccctgccatc cagcctgctg gcaccatcag 119581 gtccacccat cccatgacaa ctccagctcc tacactttta tcttctggtc cattatccat 119641 aaaccaaggt ctcacactgg aagtgcacac tgtgtccagc cttcagagtg tttccttcag 119701 atcacaagct tatgacccat gcaggggatt ttaaaagctt gaatttgttg ccaaacttaa 119761 gaaacaggag agttcacata aacgaccaga tttccagact ctcttgaaaa tcagaaaagc 119821 tggcatttcc agcacccatc gacactccag cttagctggc gctggccggg gtcccctgtc 119881 cagttaggag tgtgccctct ggtgggcagc ccccggcacc tgccatctgg atgtgcggaa 119941 accacacccc ccccaaagta acctcatgat ggcctctgcc atatcatcat cttggttgtg 120001 ggggggcacg gtggcgcacg ggctgcccct ccttctccct gaccccaggt gctcggtgag
120061 ccccatcctg ttgctggctg ggagcctctg cagaccgaga tgcagtcagt gccccccagg
120121 gcctgctggg cggctgcccc tagcctcaag tgtagcgagg gaggctggag atgcctcccg
120181 gcgcactcag cctgggccct cgggaagctg atgtgccagg caggggctgg tggaggtgca
120241 gggcctggag gaacacagag cccagcatca ggcctggctc cagaatgaag gatgcctccg
120301 gcaggaggtg acatctaccc aaacccaccc aatccctttg tgctggccag gcaaagagtc
120361 agagagagga ccagtgctcc atatggggga aaccgcacat gccatggccg gggaggtgga
120421 cggagcacag ctggtgggaa gagctgacca ggtgggtgga caggagcatc aagggcacgg
120481 tgcccggtgg cccatcactc agggggctgg tgagggagat tgtaggcagc ccagggcttc
120541 tggggggagc cttgatctga ttccagttca gaagcatggt ggctgcggca gggggaatgg
120601 gctgcggaac aaaaatgggt ctggggtcct ggggagaagg tgttacaggc acctgggaga
120661 ggggtaatgg tccagacggg agcatgagag acaaggacga gtggcaggta tgaaggaggt
120721 gaggagcgaa atggacagga cgtggtaggg tagagccggc tgagatggga gggaggagga
120781 agcacctggt gggcttccag gtctgtggct gaagaaccgg cccccaaagt tacccaggcc
120841 cccatccctg gcagctgtga gggtagtgga catggtggaa agagactctg cgggtgtgat
120901 caggtcagct ctggggctgg ctgggccctg aatgcagtcc ttgcccactt ccttatgccg
120961 gggagtggag ggggattagg cagatgcgca gaggacgagg ccatgggcag acagggagga
121021 tgccagatgc cagctttgga gattggagcg atgtggcctc aagccaagga atgctggcag
121081 cccccaggag ctggcagagg ccagaaagtg tcctccccca gagtctccag agggagcgca
121141 gccctgccga tgcctggatt tgggtcaggt tataccgact tcggacgtcc ggcctcagaa
121201 ctgtgagaga acgaattcct gctgttttaa gtggttcctt acagcagccg cagaaaagta
121261 attcagggtc ctggtgggtg gccggcaaag tgggtgccat tctccgaggg gcatgagaag
121321 aagggcaagg ggcgcaggac cctctgggct caggcatcct gggcttctgg ggaagaggcc
121381 taggaggcag tggtaaccag agttaccagg gcaagaccga ggtcggagaa ggaggtcagc
121441 agggctgtgg gaggagagcg gaagaggggg tgggaaccct gcaggcccca cgcttctgac
121501 tcatccctgg gtctcagggc tcaaccaggc ctggcgaaga ctcagcagat gcctgtggaa
121561 tgagcgaacc gatgacccca aagctgcagg ccacgtcccc caagggaggc accgagcagg
121621 caggcgggaa gaacacagcc aggcctgtcc actggcacag gggcagtgtg tttaccagtg
121681 caggagttgg gagggtccag cactgatggt cccggtgcgt ggtgtggaga aggctggtgc
121741 ctcaaatcca tcttatgact gaaactcatt ggatgaagtg caggaattaa ccctgggggg
121801 cggcagcggg caagctgtcc tggagcgtga agttctgact tcctggcacc ctttctatct
121861 ggccaggtga cctcaggcaa ggtgtcaagc tccccaagcg tccagtgact cgtctgtaca
121921 tgaggccggt catttcccgt gcacactcac acaggagcac atgcagcctg ggagacactg
121981 agaaccaggc cacgcctcca cccaagtgat ttcatccagc cagcttgctt tccaaatgag
122041 gaaaccgagg cctagatggg cagacaggct gctggggaca cacaggttct agggatcaga
122101 actcacacct acacggaaag ggcatctccc agacaggtcc ctgggccaga ctgggccgat
122161 tgagccaatt agggcaggac actggggcat gaggacccct tatggcagct ccatcttctg
122221 ggggaacttg cagcccaggt cgggagccat cgatgccaca ggcctgaggc cctggggtta
122281 ttctggaggg acctagtgtg acaatgaggc caggctcagc ctggggaagg gcagtactct
122341 ctggccggag taacccgggg gacagtttgg ggtctccctg accagcaggg gtcaggctcc
122401 cctccctggc tgcctccctg aggacaatca ctgggctgag ccaacagcac tagctccatc
122461 tgatgctgcc ctgggccttg cctcctggaa gggcacccct gcaggcgact cctcggaggg
122521 cacaggagca cactggggtc catctgaagc agggcctggg ctcaggcttc ctcacacagc
122581 cagaagcctc caagcggtgg cattctccaa cacagacgtt caacatgctc ctcacagccc
122641 cgcccgtctc tgttgaccac cgtgcgatgc gcacaacgca tgctggacga tgaacatggt
122701 ggcacctgcc ccgagaccaa aggctgaccc ccccgagacc aaaggctgac ccccccccga
122761 gaccaaaggc tgaccccccg cgagaccaaa ggctgaccgc ccccgagacc aaaggctgac
122821 cccccccccc gagaccaaag gctgaccccc cacccgagac caaaggctga caccccccag
122881 agaccaaagg ctgacccccc cgagaccaaa ggctgacccc cccgcgagac caaaggctga
122941 ccccccaccc gagaccaaag gctgacaccc cccagagacc aaaggctgac ccccccgaga
123001 ccaaaggctg acacccccca gagaccaaag gctgacaccc ccgagaccaa aggctgaccc
123061 ccccgcgaga ccaaaggctg aacccccccg agaccaaagg ctgacacccc ccgagaccaa
123121 aggctgaccg cccccgagac caaaggctga cccccccgcg agaccaaagg ctgacccccc
123181 ccgagaccaa aggctgaccc cccgcgagac caaaggctga ccccccccga gaccaaaggc
123241 tgaccccccc ccccgagacc aaaggctgac cccccacccg agaccaaagg ctgacacccc
123301 ccagagacca aaggctgacc cccccgagac caaaggctga cccccccgag accaaaggct
123361 gaccgccccc gagacaaaag gctgaccacc cccgagacca aaggctgacc ccccgcgaga
123421 ccaaaggctg acccccccga gaccaaaggc tgaccccccc caagaccatc agctgacgtc
123481 ctgccaagac cgctggccag aataatgctc ggggcggggg gcacttcacg gaagaagtgg
123541 agatcatttt attccctgat tttcaaacac ttcagtatat gcatcccagg aatgatctgt
123601 ctaaaacaca cagaagaaaa ttgacaggag agcaaagcac aaaatgtgag ctatgttttg
123661 ctgcattttt ttccgggact ttgattttcc tgctgctagt gtcaagtgta tctgttttta
123721 catgtaattt ttattaatta gaatcagttt cctctcccca ctcaataaat attaaagaaa
123781 ctccagaagc acactaggct gaaaagcact cagttgggag cctgctggtg gcctgtctgt
123841 ccaaccccac agctgtccag cctggggtct tacagaaagg ttggtacccc gacctggctc 123901 taagtgtgag tcccgctctg ctcttgaagt ctgtggatgt ctggcaaacc cagccaggtt
123961 ctcccctggg ggacagagag aggatcatgg ggagggctct gtccctgacc ttcaggtgcc
124021 accgcagggg cccagagcct ggtagtaccc gggtcatcaa gtcaagttgc cggcattcag
124081 atcctggtga gttacacaac gcctgccctg cctcttcctt ctatagaacc tgctcctttg
124141 cagttggatt gatggtaaag tagttactag aaatggcaac tagatgttaa aaatttataa
124201 agatccaaag gcttaacagc tctcctctat tactctgaat ttttaagtat tcaaccacag
124261 acagcctgga agttaggggt tcacaggaaa cacaagcatg catcctgttt ccttctgcag
124321 agcacccagg ctggctggtt cccactgccc cttcccatgg aagccacagc tgcagccatc
124381 agcagccccc cacctgtgta tgactgggac ctggtctgtc actcaaccct gtcaacctcc
124441 agcataaaca ctgtcaggtg tgtgccaagg ttgcagtggc aacaatcaag catagaaggc
124501 acaaagcata ggaagcacac aggtccatgc acagagggac ccagactttg ccaagggaca
124561 aggctgcaag tccctgttgc cctcaaactc acctccctcc gaaatacaca cacagcacgc
124621 accttgccaa gagtccccca gatgctggca tctgctaaga ttcccattcc tgaaagtatt
124681 ctaactccaa gattctttct ccccatcttc cttttggtaa tgaacctggg agatctgctg
124741 gacaacgggg caatggccag gcagcctccc ctgctgtgac agctgcctgg tggaatgacg
124801 gtctcacagg gagagctgca cagtgcctgc agttcccagg gcgcctcctc tcagagcctg
124861 ctcgggcact ctcttgcctc tcccagctcc ccagggaggt ctctaacaac cttgggagct
124921 ttcagggaag ggggctggac ccctcactac tgaacagtcc caggagtggg aagtgtcatt
124981 gagtgggatt tgagccactc cgtcctcacc actggacagt cccaggagtg ggaagtatcg
125041 agtgggattt gagccactcg gtcctcacca ctgggggctc ctttacagtt cagcatccca
125101 gaggatttca cacactgact tttccacttt tccaaaaggg acgccagcgg gcaggagctg
125161 tccatggggt taggaaacag ctgtcctcac ccgcatctcc accagctcct cctctgtctc
125221 atgggatcct cgccaggtgc cagccactcc cgtccttcct cttggagagc gaccccttgt
125281 ctagggctct gtcttggagc tatggctgga gctgggcctt ccagggttct gctgagcaca
125341 gtgaccacaa cagagttgcc tctgagctcc acagaacctg atgactttgc ttggccactc
125401 taaccttccc tggacctggt ttcaggccct acagaccttt actccagaaa gtctcttttt
125461 tggcctaagc tggccggagc caatttccaa caggaccaag gagccccgac agtcacatgc
125521 ccagcgaggc tctaaggaaa gctagactcc actttgaagg gcagggtggg gggcgaggca
125581 ggcagggaga gtaagcactg gacgctgagc caggggccct ggtttccaat gcggtcatgg
125641 ccagtcctgc ccccttgcag gcccccagtt ccctcatctg caaactgagg agctggacta
125701 cgtaacctat gaattactgc ttatcctgtt tattcatcac cccaaaaaga aaccccgcac
125761 acgttggcag gtaccgatca tccttctaaa actctactag gaccaaggag aaagaaccaa
125821 accaaaaacc agaaacccac tcctgtaaaa taaaggccaa ggccgtccca tggcacgcaa
125881 ggccttccat ggggtcccag cagccctctg tccctgggcg cacccccagt gtcttcctct
125941 ctctccgggc ttctatttgc acctcaaagc ctacaccact gcccttctct cttgttatag
126001 aggtcagtaa gtagcagaga gctggtaaag atctgtcagc accaaactga gactcccctc
126061 gactcaacca gagagtttaa aatgcaactg aaaagggaat catttttcat tataaagttc
126121 aatgcttttt ttcttctttt tttgagacag agtctcgctc tgtcacccag gctggagtgc
126181 agtggcacaa cctcagctca ctgcaaactc tgcctcccat ttttaagcga ttctcctgcc
126241 tcagcctccc aagtaactgg gattactggt acacaccacc acatccagct aatttttgta
126301 tttctagtag agatggggtt tcaccatgtt ggccaggctg gtctcaaact cctgacctca
126361 ggtgatccac ctgcctcggc ctcacaaagt gctgggatta caggcataag ccatggcgcc
126421 cggccagttc aatgcttttt aatatataac agctttatgg tgctgtgatt accattccat
126481 acatctcagc catctaaact atatgctgaa agtgaacaat tcaaccataa ccactattga
126541 ttttagaaca ttttcatcac cccaaaaaga aaccccgtac acattggcag tcactcccca
126601 tgttttcccc aacctctcct ccccaaccca gccctgggca accactaatc tacattctgt
126661 ctctatgaat tggcctattc tggacatttc atatacgtgg aatcacatgc tatgtggcct
126721 tttgtgactg gcttccttca tttagtatgt tttcaaggtt catccatggt gtagcatata
126781 gcagtatttc attcctcttt tattgtcaaa taatacccca tcacatgtat ataccacatt
126841 ttatttatcc atttgccggt tgatggacat gtgggttgtt ggtttttggc tcctatgcat
126901 aatgctgcta tgaacatctg tggacaagtt tttgtgtgga catgtgtttt cattcctctc
126961 aaagtggaat tactgggtca tacagtaact gtgccagact gtcctctaca ggggctggac
127021 cattctcagt gcccccagca gtgtgtgagg gttcaatttc ccctcatccc caccaatact
127081 cattattctt aggctctttg actctagcta tccagcaggt gtgaagtggt gtcccatcat
127141 gcttcggctt gcatttccct gacaactaat gatgctaagc atcttttcat gagcttatag
127201 gtcatttatt taactttgga gaaacatcca ttcagatact ttccctattt ttaataagac
127261 cattttcttt ttattgacct gtaagagctc tttatatatt ctagacacaa atcccttatt
127321 agatatacaa tttatgaata ttttctcttg ttctgtgggc tgtcttttca actttcttat
127381 tagtgtccac tgaagtcatg aaggactttc ttgaagtcca gttcacctat ttttttcttt
127441 tgtccacttg tgcttctggt gtcatatcta agactttgcc taatccaaag taacaaagat
127501 ttactcctac attatttaag agttctatag ttttagctct tacatgtaga tctatgatcc
127561 atccatttac agttaatatt tgtgtatggt gtgaggaagg ggtccaactt catttttcca
127621 tatgtggata tccaggtgtg ccaacaccat ttgttgaaaa gaccattctt tcccccactg
127681 acttgtcttg gacctttgtc aagaatcaat atgaggatgt atttccaaac tctcagttct
127741 attctaccaa tctatatgtc tatccttctg ccaacaccac acagtcttga ttactacagc 127801 tttgtagtaa gtcttagaat tacaaagcat gagcccttcc tctgttcttc tcctcaatag
127861 cattttggtt agtctggatc ccttgtattt ctgtatgaat tttaggatca gcttgtcaat
127921 ttctgccaca aagctagctg ggatttgata gaattaaatg cattctggag tcatgtttgg
127981 tacccattag ttcacctcct aggccaatgt ttaggaaaca ttggcctaca aagaaactct
128041 gcattagaaa ccaagggctt ggtcaggcat ggtggctcac accctgtaat cccagcactt
128101 tgggaggctg aggcaggcgg atcacgaggt caggagattg agaccatcct ggctaacacg
128161 gtaaaaccat gtcatcttga gatgggagcc ctaagtctat caactaacca ggtgagccac
128221 tgtgagcaac tctgggccct gggagagggt gcacagaggg atggcttcaa ccctgctgct
128281 agagaatgcc ctcgagagcg tctgtctcag ttctgcttgg catccctccc cagcaccccc
128341 cacctgccac tttacgcagc ctggacttga ctttaaaact gagacacctg gcaagtgggg
128401 aaatcacagg tcgaaatagc ggaattgccc tctgcatcta tgctacaggg ataatgaggg
128461 ttacaaatca gaagacattt agcatatatt ctggaaaaaa aaagctatgt aatatataaa
128521 ctattcataa tttaacttta ataaatgggg gcaggcaaaa aattgccaaa caagcccaca
128581 acaatcagac aaagagtaga ggaagaaaaa aggaattaca gtttaattgc actcgtttcc
128641 taatcttcag aatcttcagt tagcatcaac agttactggt aagtttctaa aatcagtaga
128701 tacaagctga agaattctac tcaaaattag aaaagtcaca actagtaaaa ctaatgtata
128761 ccttccaaat gactgaaggc agaccatata gaaaatatgg tagactagaa aaacagcaaa
128821 aaaaaaaaaa aaaaaaaaaa tccagaaaaa cagaaaacat aaattagatg acagaagtaa
128881 gaacaaatat ataacaataa atgtaggctg ggcatgatgt gatcccagaa ctctgggagg
128941 ctgaggcagt taggaatttg agaccaggct ggccaacatg gtgaaacccc atctgtccta
129001 aaaatacaaa attagccaga cgtggtggtg cacacctgta atcccagcta ctcaggaggc
129061 tgaggcggga gaatcacttg aacccaggag gcagagttac agtgagccga gatcatgtca
129121 ctgcactcca gcctgggaga cagagacaga ccctgactca aaaaaaccaa aacctaaaac
129181 taaacaaaca aaacaaaaca ataaatggtc agattattat tattattatt attttggaga
129241 ctccagcctg ggagacagag agataccctg tctcaaaaaa acccaaaatc caaccgggcg
129301 cagtggctca cgtccataat cccagcactt tgggaggacg aggcgaatgg atcacaaggc
129361 caggagttca agaccagcct ggccaatatg gtgaaacccc gtctctacta aaaacccaaa
129421 aattagccgg gcttggtggt acgcgcctgt ggtcccagct gcttgggagg ctgaggcagg
129481 agaattgctt gaacccagga ggctgaggtt gcagtgagcc gagattgcat cactgcactc
129541 cattctgggc aacagagtga gactccatct caaaaacaaa caaacaaaca aaaacagaca
129601 acaaaaacaa taaatggtca gattattatt attattattt tggagacagt gtcttgttct
129661 gtcacccagg ctggagtgga gtacagtggc ctgagctcag ttcactgaga cctctgcctc
129721 ccaggttcaa gcaattctcc tgcctcagcc tcccaagtag ctgggattac aggtgcacaa
129781 caccatgcct ggctaatttt tgcattttta gtagagacgg ggtttcgcca tgttggccag
129841 gctggtctcg aactcctgac ctcaggtgat ccgcccacct cggcctccca aagtgctggg
129901 attacaggtg tgaaccaccg ttcccagcca gtcagattat ttcaataaca ctctatgccc
129961 tgcaaaataa ttttacaaaa tttacagatt tatgctaggc taaaagagtt tctcagattt
130021 tttgaccact taaggaacag acacacccat gacatattgg tgaccgaaga aggcggcaag
130081 cccagctgca gcatgacctc cttacgtaaa atcatgtata tctctgtgcc aaacgtcagc
130141 acagtctaat aattaagcat gtggcctccg agtcactctg cctcgattca aatgtttact
130201 tcacctctga ctgagtggcc tctctgtgga cagtgtctgc agggttgaat ggagataata
130261 acagggtttc catggctgat gtgagggcta agcgagatac cgcgtctcta gcactgggca
130321 cagcacgtga taaatcagcc gactggcagc accatcacca tcatgatgat catggcatga
130381 cagctgttag gaaacgcgta acaaagggtc agcagtgtta cgatcggggg tgagtttcac
130441 tttttattaa tattttctgt attttttttg ttttacattt ttacaaaggg catatagcaa
130501 aacagacaat tcatgtgaag acaggagaga cggaaagggg gagagcacag agagaaagat
130561 aagggggaaa atggaataaa caagatgccg acaagaatgc ctcacggggc cagcgcaggg
130621 gccagccagg cggccttctg ctaaatcaag caacgcttga gtggctccct cgggacctgg
130681 cctgtccaga atgtcccaca ctcagccctc tgcagccagc tcccccatct ccatggctcc
130741 tgcacacacc aatgccgggg tagcctccag gaaacagagc tggccagcca gacccagcca
130801 ggacacagag gtcagtgggt cagacccaga ctctgggact gcaacaggcc tgcctatttg
130861 tgacgagaac tgacactcgt cccggccaga ttctctggct gacatttccc aggtctcgtt
130921 cagcatgaag cccacgtcgg ggaacgtccc cagtcacaaa ttaacattca cataaataac
130981 agggcgctct ctactaaaga agaaaaatga ctcgtgctgc aggaacattt gccaaactat
131041 caaaaagcaa gatttttctt tctgagcttc catgtctcac cagctggacc acagcagatt
131101 gtggccttga gacgtgtggt ggaggagagc tcatggaata aggtccaact tccccattca
131161 agatcctgcc aacaggccgg gcacggtggc tcacgcctat aatcctagca ctttgggagg
131221 ccgaggcagg cggatcacct gaggtcagga gtttgagacc atcctgggca acatggtgaa
131281 accctgtctc taccaaaata caacaaatta gcgggacatg gtggtgggcg tctgtagtcc
131341 cagctactcg ggaggctgag gcatgagaat cgcttgagcc cagaaggcgg aggttgcaat
131401 gagctaagat cgcaccgctg cactccagct tgggctacag agtgagagac tcttgtctca
131461 aaaaaaaaaa aaaaaaaaaa agaccctgtc gacaggccct tccctgggct ggcacctgcc
131521 cacaccagct ggaacctaac acctttgcac agctgttccc tgccagcctc cctgcctcct
131581 tggaggtctg cacacaccgc ccctcccttc ctccaaccag cccgggagac cagcacgcct
131641 gagcaccagc actcccagag acagagccgg cacggtgggt ctgtctgctc agggggctgg 131701 ggtggcaggg gcacatgtct gggagttgcc aacatatgct tccttaccag attccccagg
131761 ggacccaccc tggagagcaa ccaaaccctg caaggctgca ctccaagaac tgagggcctg
131821 gggacccagg accgtccccc agcattcaca gcaggctcac ccacatccac caggagatgc
131881 tgcccaggta gactgccagc accccctccc acaaaaggtc ggggccggcg ccttccctag
131941 gttgctcggg caaccatcac agggcagcac aggccggggc ttgaatagca gaacctattc
132001 tctcacagtc ctggaggcta gagctctaaa attaaggtgt gggcagaggc ggtttctctc
132061 gaggcctctc tccttggctt gtcgacagca tctttcccct gtcctcacat ggccgtcccc
132121 ctgtgtgtac ttctgtccta atcgcttctt cttaggacac cagtcattca tgttgaatca
132181 gtgacttcat tttcagttaa ttatctcttt aaagaccctg cctccaaata cagccaatat
132241 cctgatctac gggagtttag gacctcaaca aaggaactgg gggatctagg gagggcgtca
132301 ctcagcccat aacagcctcc aggcgccaag tccacacaga atcggagcag gctgctggca
132361 gggtccggtg gccagagctg ggcgggctgt tccttgggga gccactctgg acaggccgga
132421 aggtcaatgc caggatcact ccccaggggc cagaaatcca gcatggagga aagctgccac
132481 tccagggaag taggagcccg cccagggctg gccacatggg atgcccatct cacccttcct
132541 tctaaactgg gcattctcac atggggacac ggggcagtga gtgcaggcgc agggagacga
132601 gaatgctgca cagccggtag gtggtggacg ggcctcagga cccctccgcc agcagcaggc
132661 cactctctca cggtccagca ggagccctgc tccagagccc acgactggag ccagctgagg
132721 ctggtgtctc acattcctgc agagaggctg gctaaggctc ccgtgtgggg gcactcccca
132781 tgcccactgc accccagaat tttctgggcg atcccaaggc tgagtctacg cagctgttgg
132841 aagacggggt atgcaattct agatgtgtgg cgtgttttga acagcatcca ataccctttc
132901 tgtggcagct cagcccggag agcaggtccc cagtctcgag gacccaggag gcagggtctg
132961 ctccttccca cagcgggtgc tcctccagga ggggccaggt gctcagaggg aaaccagtgc
133021 ccaccaaggg cccagctgcσ tggctggctc ccagcagtgt ggggaagaca cactacccga
133081 cggacgtccc ccttagaagc aggggcagac aggaactccc atggggagag cacaggctgg
133141 gacgcagccc gcccaacgcc agtcccccca ctccactgtg caacaaggat cagcctttcc
133201 tctctcaaag cctcggttcc cccagagggg gctgcagttg agagttgatg gtgagactca
133261 gtggggcatg tcctccatgt ctgcttgtgc aaagctgccc agatcaggca gttttcccag
133321 ccagaggacc ccccctttca ctttccatca caggctgtca tctccccggg tccctgggcc
133381 acaggcccct ctcaggaccc ctccggcctc atgcacacac agagcctgtg cactgcctca
133441 ctcctgcttc ctttgaattg ggcttctttt cctgctgtga tctctggggc ccactgtgct
133501 atccagggca cgctgaccgc cgaccgtcct ctgcccgcct gcccagctgc cactcccggg
133561 cgggcagccc tgccaggccc gaggctgtct gcttcccctt ctgtccagag ttcccaaaac
133621 aaaaatcagg ccataccatc tgacgaagga tcctgtctgg tttatttatg ggaagagcca
133681 gggctctgag ggccaggttg tctgggctgt ggccaggctg ctctgcaggc cttcagacac
133741 tgcccagccc gtgtccccac ccacccaggg tggctccggg ggaggggcgg gggcagggcc
133801 ccagcactgg tgagcccaca ctggtgactc tgggatgtgt atttattcta gagccaggac
133861 agcagccgcc agggccctag gcccctctgt gggtggttgg cccactggag agccggagca
133921 gcgaggccag caatgaccaa aggcgccgta tccagaatgc aggcaggctc aggcgcacct
133981 gccctccctg gatgccacta cagattcggg gagactgaac tcatgggatc aagtgcccca
134041 cagatcctgg tcctcacaag ggacaaggcc accaggtgtc acactgggag acagtggcac
134101 cccagggtat gaaaggccac accaggctta tgtccagtaa ccctgcctgc acagcacagc
134161 acggcacggc atccataccg cagcacagcc ccgccctccg gcagtgccaa gcccgggatc
134221 tcagggcccc caccagaaac cagacaggtg agcaggtggc agctccaggc caggtgctga
134281 ccttgtgcat accaggcctt ccccgagagc aggctgcagc cccccagctg gttctgactg
134341 ccacaggact gcgcccctcc tgcagggctc tgctcacacc cacactccct gctcagagac
134401 ggcctgtccc accgccccgt gtgaaatcac acccaagcac agcggaacga tggaggaggc
134461 agctggaagg tgctttcggt ggtcaaatct ggggcaattt gaacacaata ataaatgata
134521 gtaataggtt agaacccatt gaataaaata aatatccaca gatcagtatt ggtagaaaca
134581 aataactgaa taataaataa gtgggagggg aagggcagct ctttctcaca gggtaattca
134641 actaaaaatg taaaagaaat gatgagatag aaaatcatgg tagtaaaccc catcggcaac
134701 agcacagtca ggactgcggc aggtacgact tatccgtgga ggctacaatt agtgagcaaa
134761 aggataacaa gaaacagaat gctcacatca cgtcacagca gctacccacg ggagatttaa
134821 tcatcgcaat gggaaaaaag agtgaaagag tggtttgctc atcaagccac tcatctgaga
134881 cctgaaaaaa cctcacagtc acagccctag agctcccggg gcatccagtg gaatcccagt
134941 aggtaacacc ttagccaaat gaagaagggc atcactgaca ataggagaca actggacatc
135001 ccaatgtgac agtcccagcg tggtgcccta cggagggcac agtgcttctg tgacagtcct
135061 gccagaaaca cgtaagctca agccagtaca aggcacacca gaaaaaccca tggggatgca
135121 ccgtctacaa aacagctgac cagtcctctt caaaaacatc caggtcatga aacctcagat
135181 gggaggaaac gggagagaca caacaactaa atgccacgtg ggatcctgag ggggagcctg
135241 aaccagacaa cggacatgag tcggaagact gacaaaattc agtgcagtct ggagtgctac
135301 ggttagaatg tgactggttt gttcccacca aaactcatct tgacatttgg tccccagtgt
135361 ggcagtgttg gaaggtgggg cctggggtga ggtatctgaa tcatggaggc cgatccctcg
135421 tgagtggctt gatactgttc tcaaggtagc aagggaattc ttgctctgga gaggcttgat
135481 tagttcccga gcctgggttg ttataaaagc aggacactcc ctgggtttcc cttctttgca
135541 cacatgggct ttccctttga ccctctccac cacgttatga cacagcacaa aaaggcctca 135601 ccagaagcca gggccatgct cttgaacttc ccagcctgca gaaccatgag ctaaataagc
135661 ttcttttctt tataaattac ccagtctcag gtattccatt atagcaacac aaaatagact
135721 aaaactaaga cactaagtac caacgcttag tatcaaccta caaagttcct ggtttcagtc
135781 cttgttctac gttgcataca gaggaagctg ggtgaagggc acagaggaaa tctatgctat
135841 ttttgcaact tttcttgcaa tttttccaag acagcataga tctaaagtta tttcaaaatt
135901 aaaactttaa acacataaaa ataaaactgg gccccagcct ccctcagtgc tctctggccg
135961 gtccattctt cacattggct gcctttccct ggagtggagg cgcccactgc atccccagtg
136021 tccagggagc aggtcctgta gaaggtggta ggttccaggg atcggggagc aagtacagag
136081 gccctgagaa ggaagcaagc ctggcgtgtt ccaggaacac cagggagaac cgtgtagccg
136141 gagcaatgct cttgtgcaga gggcctatgc ctgagccgcc ctgtgggccc tgccgttccc
136201 ttcagggcac tctccaaccc tctgccctgt gcatggggcc acggatgccc caggagctct
136261 agggctgttg actatgaggt tgcttcaggt ctcagtgagt ggcttgatga gcgagccacc
136321 ctcactggcc aggaggggac ttccttcaca ggtgtgaatg ggactgagcc accagcatga
136381 tgctgacacg tgggttttga ggattcccac tcacatcaga cagaatgagt gcggggctct
136441 gggatacagc tgcccaagcc tcaagcctga gtggcacttg tgggctcctg catcggctgt
136501 ggggccacct ccgggctctg gtgttcaggg gtgggcagtg gcagcagaca tccttcactc
136561 tgtgcctctg tcactggtgc ccagggcggt ggcccacacc ctcaaaggtt ccgtgtcatt
136621 tccgggcagt cttccagggc tggctgcatc cacctgcttg gagtgctttc agagggaagc
136681 tgttgccctg caatgccacg acccttcccg tgtcctctct tgcctccaag ccgtgctgga
136741 catcatgctc tcctcccagg ctggtctgca gagggatgga atgcctgtca caactgggat
136801 ccctcttctc ttgtcattct gcctgctggt ggcagagtgt ggaaggcggg agtgtgccca
136861 ccattaaacg aggttgaatt ctgggagtgc agaagtaaca gcctcaggac tgatggggaa
136921 gatgaggctg caagatgtgt ggttcttccc ttcgctataa aggtccaaac gatatttatt
136981 tatttattta tttatttaga gacaggatct tactgtgtca cccactgcag tacagtggct
137041 caaacacagc tcactgcagc ctggaccccc tgggctcaag tgatcctccc aactcagcct
137101 cccaagtagc tgggaccaca gacgtgtgcc acaacagcta gctaattaaa agaaaaaaaa
137161 aaatttgtag aaatgaggtc ttgctatgtt gccagggctg atgttgaact cctgggctca
137221 agtaatccta ctgccttggt ctcccaaaat gctgggatta cagatgtgag ccaccacacc
137281 tggcccaaac attaaattta acacgaccag atgaggacgt atggctcaca ttttcttgca
137341 cactctgggc aagatccaca ttggtggtca tcattaatga agcacggtaa ccaccttcaa
137401 gggaacaacg gaagccggca ttcccggggg cagagagaag cggcggagtc aggagaaatg
137461 ccacaaccag cactaaatac atggggctgg ggaatgcggg gcaagaagat atacagcatc
137521 tccacacaaa caggttccaa agagccacac attgtgagcg gtaacagctt tgctattacc
137581 ccccagctgt gggagatata aatatgaaat tagctgggac agcacactcg accataaaga
137641 acaggaagag atagctcctg agcctgagca gtaacgaggg tctctgcaag cactgagcag
137701 acagtgagca aatgtgttcg tgcttctcct ccccgtcccc taaatcttcc ttgatacatc
137761 ttgctattcc ccatgtgggc tcatgaatct tgttataaat tttttaatca aattgtctat
137821 atagacagga gtcctgcagg aaatatatgc ccagggcccc atgtatccta gggacagcca
137881 gccatgcctt tgggaacagc ctagaaggac tgtcaggaag gggcctgggt gggtgggagt
137941 cagcttgccc aaggtgactc tctctccttg caagatacat ctgagagaga agcccattgt
138001 aagcagggcc aatccaagct cccaccccac cctggagtgc agaccactgc ccagacggct
138061 tcctgaggtc ctggctgggg ccctccaagg taccccattt ccaggcctcc agccccagcc
138121 ccccaatagc ctgccttgaa ttgtcttctg cttaagtgag ttgaggtcag ttttgccatc
138181 caaagagaag ccctcctgtt ttcctagagg ttgtcaggag ctacgctggc cggtcccctg
138241 ggcttgggac atcctctgtt gttgggggga gagggtggga agcatctttc ctgcagccat
138301 gacctcacct tggtgacagc cacagcttct cactcacagc actggtgtaa gtgctaacct
138361 gaagccgctc ctccttgtcc acggggaaga cagtctgacc ccactttcct ctgctccccg
138421 aaaataagga acgttattgg tgttgctttg tcctgacaga ctcacacgtc cttaaaaagt
138481 gctaatcttc acaaaagagg cagcggcctg tgccttcctt gaggaaagtc agattaatta
138541 gctgactccc acatgagcag cctctgattc ttgcaggctt tgtttatgga tcagaaatca
138601 ggcttgaagt gaaaactgac atctcaatgt gaagagtatt ttccctgcta actgcagtga
138661 gtcagagccg tgcgctgagc tagacagata gggaacatgg ccttcccatg tggactggag
138721 tgtgccaacg cctccgggcc acagcccagg acaagcgtgg gacatcagcc tcccattgct
138781 aggccagaac aggccagtgc cccatagatc ccagcccaag acaagcaccg gagttggcat
138841 tccagggtag ggttttgttt gtttgtttgt ttttctcaag atggaatctt gctctgtcgc
138901 ctaggctgga gtgcagtggc atgatctggg ctcaccacaa cctccacctc ctgggttcaa
138961 gtgattctcg tgtctcagcc tcccgagtag ctgtgattac aggcacacgc caccacaccc
139021 agctaaattt tttttttttt tgtatttttt tagtagaatg gggtttcatc acattggcta
139081 ggtggtctcg aactcctgac cctgtgatcc gcctgccctg gcttcccaaa atgctgagat
139141 tacaggtgtg agccaccgca cctggccaag gtttttttgt ttttttgttt ttttgtttta
139201 aggtatttgt gcatctcaaa cattccactt aatgactggg aactggggcc tgσaatccca
139261 gcacttttgg gaggccgagg caggaagact gcttgagccc aggagttcca gaccagcata
139321 gtgaggcctc atctctacaa ataatttaaa aattagctgg gtgtggtggt gcatgcctgt
139381 ggtcccagct acttgggagg ctgaggtggg agaatcacct aaaccctgaa ggtccaagct
13g441 gcagtgagct aagatgctgc cactgcactc cagcctgggt aacagaaaaa gacactttca 139501 aaaagaaaaa atatgactgg gaaccgggag aaagatgttg atgaaggcac gcagcctaca
139561 gtcagagctg acagcccaga aacacgtcca gccagccaat tatttttaat gaatgccctt
139621 cctttggtga ctcaatccca tgaacaggga agatgggtgc atggctagaa gctctgtcca
139681 ggctccgagg gctgcccagc agacccaccc tagggggtgc caggatcaac ccgacccagg
139741 gatgctgagc acccatgcaa gtctgaccca cccacgtggc ccaaggaggc agcttgtgga
139801 ggtccggaat ggtggtctgg agattgggca cccacagact tggggagtgg aagggccacc
13g861 ccaagccctg cccccgcccc cactgcagct tccccgcagg gctgcaccca catccgcagg
13g921 gtggcccctg ccccgtgtgc ccagcttcca aggtggcctg cccctgatgc cagagaaact
139981 tcctgctggc caagcggagg ggcttgcttt ctagggtcag caggaaatgt caacattttc
140041 cctgaaaaat σcttcaattc cctcattgag tctccagtag acttaggtca tgtatacact
140101 caacaggaca actcttttcc accccaaatg ctgacagcct ctgaggcagt ctaaagaagg
140161 aaggaagagt cactgtgcag actcctggca tggaggccct cctgtcgctc tcaactactg
140221 cctctaggcg aacgggcctg tggggaactt ggcgggttcc cactggccgc atggatcatt
140281 gtttccactt caaaaccagg ccttgagcac cctactggag gctgctgggt ttgtctgtca
140341 tcctcagagc ctgagagcat ctggcaccag gcctggctga ataaatagat tctggattag
140401 aaaggaaacc tggctttgaa aagacacaga gaagaaccag gtccctgcgt cccttccttc
140461 caggctgatg ttctgggctg gcgggtctct gttgggctcc ccaccccttc accttctgcc
140521 ctgtcctaca gcccagtagg cagacctgat ggactggctc ctcctggctc tccctgggtg
140581 aaggggggca ccgacaggaa gccagggctg gggagagaga cagaaggttt tatttctccc
140641 gctgtggtgg cccccagcct ccccgccctg caagctccct cgtcctgccc gcagctctgt
140701 gagttgtgcc tttgtcaact cctttctgtt gatcccttat gtgtcccagg cccctgactg
140761 atccgacatg ccctgtagcc cgaccaggca gccctcactc tcatagtcca ggtgctggtc
140821 ccatctctag ggtttgggat gggacttcca cactccagcc caatttccac cctgaagcac
140881 acgggtgagc cagttccctg caaccaccac agactcagga cacaaagtcc caggctggtc
140941 cagaacattc tgagcagggc agaggagccc cgtccatggc ggctggggca gtcccgcaag
141001 tgagagtcgg ggtgggagga gctggaggct ctggaaggga ttcaggagca gccaccaagg
141061 ccaccttcca cacacgtcct caaaagccct tccatattcc gctgaaacca ctagtggggc
141121 ctgtgctggg agcaagggag gcgtggagac aggtggggct gtggaaggag gctgccatga
141181 ggagggaagg ctcctccaac ccaggacgcc ccactgcagg aggaaatgcc tttctggctg
141241 tggtccagga gactgagggt cctgctcagc cacacagcac gtgccaaggt gcagagccca
141301 ggggaagagc aaaccgagga gctggcggtg cctcggacga tgcagtgatg gtgaagcagg
141361 aggatggggg aggcctgagc cgtggggaca ggagaatgac cacaggatcc acacctctgt
141421 ggtccgtggg acctcagcag acgctttggg tgatgccaga gagccatgga ggaggtggcg
141481 gcaggggctg tgcttctgag aatgctgaca atgatgggac ccgggagcag ccggagctca
141541 agggacgggc aggggcaatg ccggggcctg tctgtgctcg gaggaggggg aggtgggtga
141601 gcaaggaggt gggtgagcag ggagcgggaa ggtcccaagg ggggatgctg cctgcagagg
141661 ccagcagtca ggaatgtcga agtagatcct tcagcgaggc tggggcccct gctcggaggc
141721 aggaaagtaa Sggaggaggg atggggctgg acccagcaat tcagcaagga aagcaggagg
141781 cgggagacag tggtacaggc agggagcaag tacagcaaag aggaccagtg gcatccgact
141841 cggataagga aggaccgcga ggcaggtgga gatgggctca gtgggtaagg tccccagggg
141901 cggcctgggc agagggcagg agggagaggc ggcgggcaga gagaggctgc tgcgtgctgt
141961 gggtcaggag ggtggtgcct gggaagacca gctgcctgcc tgctcccagg gtggacaggg
142021 gacaagtcaa gcataaagat gcaaaggtgc aggccgaaaa aaggacgggc cactggtatc
142081 actaacacaa ccatcaatgg gtttaacatt gcagttagag atcaaccaga ctgagatgga
142141 acaaacaagg catgccgtct gtaacacatg cctgaaacat gctaaaagag agacagagaa
142201 aactgcaaac ccagaaagca gggtgtctgt agtatcatca aaatagaact cagagcaagt
142261 actaaatgac tggaaactcc tgttgtattg acaaggcttg gtgaaagcac acagtcacca
142321 agctttacaa accaagggcc gcagcatctg ccatggttag aaacacaagt ggctcaacag
142381 ccctgtcaaa gggaaatgcg aacggccact cccagtgggt gacaggtctc ctagaccaca
142441 gcagaggggc acagactcat tgactcggga aatgggccgg attgatttct ggatggatct
142501 gacgacttac aaccgaaagc aaatgagtat tctttacaag catgggggag catttacaaa
142561 aattgatccc ggcctcccct gcctgcctgg cctgaatccc ccaagcctgt cagccgtagc
142621 ctcccacccc acctgcctgg caatgcagaa acctgagatt gctgcttctc ggcaccaaga
142681 accaagaggt gaagttggta tggggacccc cttctgcccc actccctgct agtactgtcc
142741 agccagaagg ccctccccac agcctgcccc tttctcttga ctgttccctt ccccaatacg
142801 ctgaggcccc atgtctccca ggaccctccc tcaagacccc ggcttccctc tccagggtga
142861 cttgggccct tgcatcatgg ggcataatgc caactcccca cccctactga tgaagtcact
142921 ggcagagtgc ccccaacgcc ctccactata atcccagagg acggagagct cttgctctga
142981 gccgagacaa cccactgccc accaccagct ccctcagggc tctccacaag tcccttctcg
143041 cctcccctgc tgcgtcttcg gcctcctcct ctctaaagtc ctctctcagc ccaacaacag
143101 aaccgggtct cttcaatcct gaacaagaag actctgcttc ccctccagcc acaggacctc
143161 ccttccctca cagcccttct cagσaggctg gcctctgctg ctccctccca cgcaccaatg
143221 cccatggcct ctgtccctcc tccccagggc cccggggacc tccacaccct cctgctcagc
143281 ctctctctgg ccgcccccag ctgctccggt ttccacagca ccagaggcca gggtcccctc
143341 gtgccacagt gaccctgcaa cgcagattcc gtgctccctt cagaagccca cctgacattc 143401 atagaagctg agcaaacacc aggagacaga ggcaatttca gaaattcccc gaggctcggg
143461 gaacccaggc tgtccccttc actcctaatc tgtggcaggc ctggccctgc caagcctcca
143521 tggagatgag ctcttcctgt cccaaggtga tggtgtgaag cgggcctttg gaaggtgatg
143581 aggtcatgag ggtggggacc ccgttaatgg gattagtgcc cttatcagag aggcccaggg
143641 agcttgtgca ccctccactg tgtgcaaaca cagcaagaag gccccagcta tgagcgagga
143701 agcagccctc accagacacc aaacccactg gcgccccgat ctcacatgtg agactccaaa
143761 actgtgagaa ataaatttct gttgtttcta aacacccagt ctgtgatatt ttgttatggc
143821 agcctgaacg gagggacacc tgcagagcct gggatgctca gaatacacac gtggcaggag
143881 gggtgtggac gggctctacg gaactgggag atgcctagaa atgctagagg ggttgagggg
143941 gaggcattca caagcccttg taggaaactg agatctgcgc tggttagggg tggggtgtca
144001 ctggaatggc aagatgcaga tataaatgct gacaagaccc aatttaaacc cagagatgct
144061 aaggtctgaa aacatttgga ttatactagg aatcaacgca aagcttaata acctaaaatc
144121 caaccactcg gaagtttttt caacattcct ctaaatagct cttaagttac tggaatcaaa
144181 atcataaatc tttttaaaat gatgacagtg agaattcagc acatcagaac ctgtggatga
144241 gaccaaagcc accaccagaa gcaagttcac aaccttctta attatagacc agagtgaaaa
144301 taaatgaagc cagtgctcca gtcaagaggg cagaagagag agcaaccata aacctaaaga
144361 tgttgataca aatagcatga gtgacaagat ctcacttctg agtgtgacat atatgtaaca
144421 agatggaaaa acggttagtt tgtatagctg taacaaatta ctgcaaatgt agtggcttaa
144481 aaacacaaat ttgtccaggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc
144541 aaggtgggtg aatcacgagg tcaggagatc gagaccatcc tggctaacac ggtgaaaccc
144601 catctctact aaaaatacaa aaaattagcc aggcgtggtg gcgggcgcct gtagtcccag
144661 ctacttggga ggctgaggca ggagaatggt gtgaacccag gaggcggagc ttgcagtgag
144721 ccaagatcac accacagcac tccagcctgg gcaacagatc aagactccaa ctcaaacaca
144781 cacacacaca cacacacaca cacacacaca cacacacaca catttattat ctgacagttc
144841 tagagatctg aagtccacaa tgggtctcac tgggctaaaa tcaaggtgtg gggagggctg
144901 cattccttct ggaagctcta aggagaatgt ttccttgttt ttttccagct tttagaggct
144961 acccacattc cttggcttgt ggccccctcc tccatcttca aagccagcac cggagcatct
145021 actgacccct ctctgactct gaacttctgc ctccatcttc tacttttatg aatccttgtc
145081 atggccagct cacacctgta atcccagcac tttgggaggc tgaggcgggc ggatcacaag
145141 gtcaggagat ggagaccatc ctggctaaca cagtgaaacc ccgtctctac taaaaataca
145201 aaaaattagc caggcgtggt ggcaggcgcc tgtagtccca gctactctgg aggctgaggc
145261 aggagaatca cttggaccca ggaggtggag cttgcagtga gcctgagatt atgccactgc
145321 actccagcct gggcgacaga gtgagactcc gtctcaaaaa aaaaaaaaaa aaaaaaagaa
145381 gaatccttgc cattacactg tgccatccag gataatctcc ttatcttaaa agtcaactaa
145441 ttagcaacct gacttccatc tgtaaccttc actgcccctg ctatgtcacc tgatttattc
145501 ccaggttctc gggactggga catggacaac tttgggagaa ggattattct gtctctcaca
145561 gagactatct caaaagggta ggatttcatg gtttttgctt tctccttaat acttttctac
145621 attattcaat gataatgacc atatgttttg tatgttcaaa agtaattttt aattgtgaat
145681 aatgtaaatt attgtgaatc atgttttgtc agttgttgtg aataatgttt aattgtaaac
145741 aatggaaaac taaagaaaca aaagaatagc atcctcttat agcacccatt gatgtctttg
145801 caacactttt tggctggtct tttgtccccg tccccctgac tttgagctgc ctgaggacaa
145861 gccagacccc ccttcacttc tgtggctcta gcagtaagca tgaggacttt ggcacagcag
145921 gctttagcag acatttctca aagtgaagat aaatccccta ataaaggagg ccctggttta
145981 agaagaatga tgtgcacact caaaagtgca ctttaaggcc aagctccgaa taaacacgat
146041 gatattattt tatttaagag tcttcataca tacaacttaa ttcagtaaca gtctgagaaa
146101 cgcaagccag cagacagata aaccgttatg gctctggctc tggcaaaaac tcttcatcta
146161 cgcggagcca gaagaaagcc aattaaaagt cggagaggtc ccgcaggaca gaggccggag
146221 gatgtcccca cacactgagc acaagcccca aacacaggcc tccccagtct ggagccggcg
146281 gccagccccc tcctggcctc agtgaagcct ggactcctca ctctgtccaa gtgggaggaa
146341 ctggtcccag ctgcaagaac cgcctactgt gatctgggca aaggttctgg aggctctgct
146401 cgctcctgtc ccccaggaaa aaaaaaaaaa aaaagacagc agagggcatt gctcaggggc
146461 ccagcctggc tgtcatccct gaacatcctg ggctgaagga aagaattgag cccagccgaa
146521 acttgagatc tttagactta aatccccact ctgtcacttg tggctatttg gcctctttcg
146581 acctctgctt ttccgtgtct aaaatggcac aatattacct actttacaga gttgtcaagg
146641 gattgaaaat aagataatga aggcaaagga agtgagctca gtatcattat gcccatttta
146701 cagattggga aacaggctcc aagagatgac atgactcttt caggattaga cagctaatga
146761 gtggtggatc cggatctgct cgcacagggc tgggctcctc cccagccccg cactgggaca
146821 ggggcatctc ttgagggctg ccctgtggcg cccagatgcc gcagggagac aaggctgtgt
146881 gcacagatct ctctccactg ggcagcacct gagtaactgg gggagagaag tgggtttcaa
146941 gcatctcctt tgtgaaccac tgggcttaag tatgctgaac ttcagttttg acgcagaact
147001 tggagacaac ccatcctctg ggaaaagaca caaatgaggg caggacccct gcaccatgtg
147061 ccctgctgcc ccagcagtgt cctctcatcc agcgtgtgaa gaaggagtgc agccggagag
147121 ccggtggcag cagggcgtgc gggatgcccc gctcacagtg tgctgtgcct gggagaggag
147181 cgagggcagg cccccagctg cttgggaaca gtcagcctgc acacctcccc cctgggtgcc
147241 cttccaaggc agccctcagg ccccaggctc cgggactccc tgcagaggaa ctgcaagcca 147301 gtcctggccc agcacagccc ttccgccagc ctctggccag cgtcaggaag gggagtgtag
147361 agtgagtagg aagccacaca ggagcagaag ccgggacttc tgcctctcac cccactgcat
147421 gtatgaaaat agacgggggt gatggccggg tgcggtggct catgcctgta atcccagcat
147481 tttgggaggc tgaggtgggc ggatcatgag gtcaggagat ggagaccatc ctggctaaca
147541 cagtgaaacc ccgtctctac taaaaaaata taaaacatta gccgggcgtg gtggggggcg
147601 cctgtagtcc cagctgctct gggcgacaga gcaagaccgt ctcaaaaaaa aaaaaaaaaa
147661 aaaaaaaaaa aagcggggga gtgataaggc cccggacaac ccaaactgca gcaagattct
147721 ctgcggaggc agagctgcct cctcctgggg gtcctctgga ccaggaagga gccctgagga
147781 cttgtggccc agtgggtccg gcttcccaac ctccaccttg ccagcagcac cgatagatgt
147841 ggccacaaag gtgcattcac atttgcgacc tgtggctgaa tgcagaccct gggtgctatc
147901 tcccgggggg gcaaatggca gtaagcaagc aaagaggaag tcgacagaga gtgacgcagc
147961 cgtgaggaca acagcacaga gtattgttga ggggggcggg ggacttcctg gaagagatga
148021 cactggagct gaggcctaaa tgattggaaa gaggcagcga tggagagatc tggggaagtg
148081 ggctccagca cagagaacag cacatgcaga ggacccgagg tcagaacaga cctgccatgt
148141 ttgaggaaag ggaagaaggc caatgtgagt ggagtgtgga gagcaaaggg tgggcggggg
148201 cgagggacag gagggcagag tggtgggcct gggtggggta caggaggtca gagtggtggg
148261 cgggggcaga ctgcacagag cttcctctgc tggggggagg agattggatt ttctcctctg
148321 tgcagtgggc agcccctgga gggtggaaga gacctgattc ccctgtcagt tgctctgggc
148381 atgttgtgag aattgctggg ggcaggatct ccctccctct ctctatgaaa ttcctgttca
148441 gcagggatct gcctatggct gtatttctgc tggtagaagt ccctccctga ttataaaccg
148501 ctcaacacat agagaggtcc ctaggagaag gttcaggttc cagtaggatg gtgtgagcac
148561 gcctcacctg catcccccac tgcctgcagc cacccaaatg cactggattc atgagcagct
148621 agctgaggac cctgcaaaat aaataacagc atgcagattg gggaagaaga ctagaatgtg
148681 aggttcagca aacccgcaga gtttactctt cattctctgg tattcctcag cctagataca
148741 aggcaggtca aactccagaa gcgggcactg ggtacagaca gacagagctc gagacaagcc
148801 ctgttgttgt agctcaagga tagaaaaagc atttccgaat gctcagagcc aagccaacac
148861 ctcatttttc tttcctattt cctttttctt ttcttcgtgt tctcacacgc cagctcatgg
148921 cagcccacag gcacctaaaa ctctaagagg ggagcctggc tgtgtagctg gaagtgctgt
148981 ggtcctagaa aggtggagtg aaaccccatt gctctttcct cttttggtcc tcccaggagt
149041 gtagttgcag gaagtgtgca agacagcagg gtcaataaag ccccagcttt ctggccagag
149101 agatttaaca aggagccgca ggaaactgga cagggctagg aagatggcag agacagcaga
149161 gcttggggaa ctggcatcag aaagttggtt agaaactcct gggctcgtgc ttgagccgtg
14g221 cacgagtggg tctgacccta aacaacacgc cataggttct ggggactgac ttaggaggtg
149281 gaccaatgcc caggtcccag acgtgccact gggttgtgtt tacatgggat tgatcagaat
149341 aggactgcac aggctttgaa aatggacctg acattgaacc gcaatccaca ggcacattgg
149401 aacttgcagc cggaacccaa ttaacccaag ggttaattac ctgatcaaac aaaaataatg
14g461 accttctcca tagcatttaa acaagatcca aagtctcata gggtaatatc aaagtgtcca
149521 ggatacagtc caaaattact tggcatacca agaaccagga aaatctcaac tcctccaggc
149581 aaatacaacc aacagataac aagactgaga tagcacatat gttggaatta actgacaatg
149641 atcttaaagc agctattata aaaatactcc ataaagtaag ggcaaaaact ctggcaacta
149701 atggaaagat agtctcagca agaaacggaa gacatatttt taaaaaggac caaacggaaa
149761 ttttagaact gaaaaataca ataacagaaa ctttaagaac tcactggata ggctcaagag
149821 cagaatggat atgacagagg aatgagtcag tgaacttgag gatagagcaa tagaagttac
149881 ccaattcaaa ctgcagcgag taaaaatatt ttataatgcc aagagcctta gagactgtgg
149941 gaaaataccg aaagatctaa ctaacagtca tgtcccagaa ggagaagaga aagaatgtat
150001 tactaaacaa atatttggat aaataatggc tgaaaacttc tcaaattctg tgaaatgcat
150061 aaacctacca attcaacaga tcggcaaacc tcaaatgaga gaaatccaag gaaacacaat
150121 cccacacgtt ataaacacac tctgaaaaσt atagacaaaa aaaagtcttg aaagcagtca
150181 aagaaaaaca gtgcattact tataggggaa aaatggttca gataactgca gatttcttat
150241 caaaactgtg aagtccaaag gaagtgcaaa acattgttaa aatgctgaaa aaaaaaaaaa
150301 agaactgtca acccagaatt ctatctccag caaaaataca cttcaagaat taaggagaaa
150361 taaagacatt ctcagatgaa gcaaaactta tagaatgtgt ggccagcaga tctaccctaa
150421 gatggttgct gaaggaagtt cttcagacag ggggaaaatg atgctagaaa gaaattttga
150481 acatcaggaa taaaggaaga gcaacagaaa tacctgaaaa aatataacag attaggctct
150541 tgcgtatttt aaagaggaat gataatgctg tctgatgtag ttttccatgt atgtaggtgt
150601 ataaaagaca acaacattca ggggaggaca gagggaccta tatgatggca gggtctcaac
150661 attcaacttg aagtggtaaa atattgattt gaaaaagact ctgaagagtt acataggttt
150721 attataatcc ctggagcaac cagtaaacac tatacaaaga tatacaacca aacacaatag
150781 gtaaattaaa attgaatacc aaaacatgct caaatagaaa aagcaaaata agcccaaagc
150841 aagtagaagg gaggaaatga taagagtaaa aatcaatgaa actgaaaata tgaaaataat
150901 agagaagatc aatgaaacca aatttggttc tttgtaaaga tcagtcaact gataaatctc
150961 tagtgagact gaagaagaga aacagaaaaa aatatgaatt accagtatca gaatattttt
151021 aaaaaggata tcactaatga catcacagcc ataaaaaaga taatggaata gtataaacaa
151081 ttctatgcat ataaatccat cagtgttgaa gaaatgcatg atttcctcaa aaactataag
151141 ctaccaaaac ttacccaaga caaagtagat agcataaaaa gttctgtaac tattaaagaa 151201 aaagaattca tagtttaaaa tcctgcaaaa aagaaatttc caggtctaga cggttttact
151261 ggaaaattct actaacctct caggaaaaaa tggcaccaat tctcccattc attttatgag
151321 gtcaacatta ccctgatatt aaaaccagac aaagacagtt caataaaaaa aaaaacccta
151381 caaaccaata tccctcatga acctataaac caatatccct caatgaacat agacacaaaa
151441 atcctcagca aaacactggc aagtctagtc cagccatgta taaacagcag agtgcacaac
151501 agacaagtca tgtttgtcct ggatttgcag agtctggcac aatatccaaa agtcagtgta
151561 acccagcata ttaacagact gaagaaggaa aaaaaatatg cttatatcaa gtgatagaga
151621 aaaccatatg atatgattca ttcatgacta aaaattaaaa actctcaact aacagagaaa
151681 gaaacgtgct caacctggta agaatatcta caaaaaaact aaagctaaca caataccgca
151741 tcctgagaaa ctgttttccc ctaaaataag gagcattttc acgactccta ctcaaccttg
151801 ggttgagtcc tagacagcac ctctgtacac acccagcacc cagcacagac cctcaggcca
151861 gggcaggaaa gggccccaga gagcttcccc aaaacccgtg ttcctgggga aggtggatgt
151921 ccaggaaggg tgactggccc ctaaagccta ggggaagcgg gggccctcct gctccagcct
151981 catgaagctt tgatctccag tgccaagccc ggtgccagca gagagccagg cagatgaact
152041 caaccaggga aaggacaccc aggaaggaag caactccatg agatcgagtc tcatagcacc
152101 aagtgctccc acaggctctg aggacatggc tcttattcca ggaccaggcc tgacaggagc
152161 acagcctgag ggatgagagg gcagggcagt cttctgctgg gtggggaatt ggccaccagg
152221 gccagtccca catctgttgt ggccctggca ggatcaaccc tgggcctgag tccttggagg
152281 tgaggccagc acgtagtaga ggggcagccg agtaagaaga atctctcggg gaagtcagtg
152341 gccagccagc ctaagcccgg cccagaccct cgccctgcta gcatgagaca gacacagggg
152401 gcccgcactg cagagctgcc ccggcccacg cgcccctgcc ctgctgtgct ccgccatctg
152461 ccccagcagt gctgtgagag ca cgcaccc tgcaagcctc agccttcagg gacggcaaga
152521 cctggggccc acaggaggtc caccggccct ctcagggctc gagcacccgg ccaaccctgg
152581 gtggccactg ctcagcactc caggacagct ccatgacaca gaagcagctc tgcccatgag
152641 cattcaacag cccggtccgg ggggcaccac cacgcagggg cttcccgggt catgctgcac
152701 catccactaa tagcaccatc acgtatgcca ggctgggagc ccgggcgtcc caagcctgtg
152761 acctcattct ctatgctcct cacggctgcc ccacagaatc tctgaaacac gactcagacc
152821 tgtcactgcc tgcccaaagc cctccagcgg cttcccacca catgactgcc ccggtccccg
152881 ctgatttctc cttcactcaa gtgccagccg tggagatctc ctctgtgtcc ttggcacact
152941 tcaactcagc acctgcctca gggcctttgc acctgctgct gcctccacct ggaatggcct
153001 tcttccagaa gtccaggtcc tagctccgat gcctcctcac aaggaccttg gtgaagggtg
153061 tcccttctcc atcacactcc acactgccat cctgtcctat ttttttgtaa caccatttcc
153121 caatcatcga cacgtgggtt ctt attggg tcactctctg ccccctgacc agggatctta
153181 cgagagcaaa gttgtccttg ctgggtccac gtcaccagac cagtgcctgg catctcacag
153241 gcatggagtt gagtacggga ggtcgccggc cctcccgagg ctcccttccc ctacttcggg
153301 atggtgtaag gtttccttgc caaggtccct gtggtgcaga gtgggccaag tttgccgcct
153361 tctggagcga caacaaggag aaaacagggg tttaagtgga ggatccggtg ctctgatttc
153421 tccccagtta gtaaagcatt caggctgctc ggtggaggtg ggaagacagg cgctgagagt
153481 tgtctgacac aattgtctta gcagcaggag acgctgatgg gatgtcggga gtcaccagga
153541 ccatctgaca aatgaccgcc ttggggatcc gtggagctca gcggtgccca gagagagcac
153601 tcgaaatgcc agctggaaag gtcacgcacg ccagctggaa ggggagccgc gcagcccctg
153661 ggcaggctga ggacaggaac gggcagccgc cactgttcac gagcaagggt gcaggggcac
153721 cagagcccac aggagctcct gcaatgcgat gaccatgcct gcaggccccc ataatagaca
153781 gcctcatttt ttttttctag gcaaaacttt gggaggatcc tttttaattg tatttgcaaa
153841 acagtttctc ccaacatgat gcccatgtgt atgtggattg ggggaaattc ccaaggcctc
153901 tcagagaagt gcctccttcc taaggtggtg tcccagcaga tgaatctggc tggcgtcctg
153961 agtggaagca gggcgcgggc tgccatggaa ccccaccctc ctgcaggttc ctggcccctc
154021 tgcctcctct tccttcccac cccaggggcc ctgggatgca gctaggccag ctgggagcca
154081 gacagccact gaagccctcg gggtactgtt ccctgccttt agcatccccc tcagctgccc
154141 attcattcag ccattcttct aggaggacag gccaggccat ggtgaggccc tgggtccagg
154201 gaaagatacg aagagggctg aggcgggcgt tcctgccctt gggtctcttc cgctgccctg
154261 gcagccccgt gcctcctgac tgtggactgg agttctgcag ctgcgccatc cacaggaagc
154321 tacatggaga gatgggccag ctcagcagag aggcgcaaac accaattcag ttgaaaactc
154381 tgtgttcccc gggtagaggc cagttaggag ccagcatgcc tcccaagggt tgtgcaggga
154441 gacttcagcc aggcacccac tggggcagac ccagtcccac tgcttctgcc ttcagtggcc
154501 acaggcctgg ggccattggt ggatagagct ggagaaaggc cacctcttcg ggacccaggt
154561 cacaggatgt ccccccaaag ccatcccagt cagatgtctg cagacacctg ctcccctggc
154621 aacagtgacc cagacctgac cttcaactct aactgtgcac agcttcctag cccggccccc
154681 aagcctgaag cctggtccct ccagacactg cagaaagctg gggctgactg taatcccagc
154741 actttgggag gccaaggtgg ggcgggtcac gaggtcagga aatagagacc atcgtggcta
154801 acatggtgaa accctgtctg tactaaaaat acaaaaaaaa tagccacgca tggtggcacg
154861 caccggtaac cccagctact caggaggcta aggcaggaga atcgcttgaa cctgggaggc
154921 ggagttgcag tgagccgaga tcatgccatt gtactccagc ctgggcaaca cagcaagact
154981 cagtctccaa aaaaaaaaaa aaaaaaaaaa aaaaaggctc tggccctgcc acttgaccgg
155041 gtgggtcacc tctccgtgcc tcagtttctt ctatttaaaa tgcatagggg aggagctctg 155101 agggcaaaac accctgggtt tgcctcaggg cagggcagga ccctggaccc agcaggcccc
155161 cactgcatgt ccctcctgtc ctccctgccc cacccctgcc ctctggcttc tggggttcaa
155221 gtcagggagg ccttgggagt agcctgcggc cctggggaca gacaagggtg cccctgaatg
155281 tcctgtggat ctgcccaggt tgatgccttg actgctcctt cctgtcaccc aggaccctcc
155341 aggagagacc accccggact acgcctgccc agggctccct gcacgtccca tgtccccaca
155401 gcgctcaggc gctgagatgc tctgctgtct gctgtggggg cctgtggacg gccctcctcc
155461 cccaccaggc tgcagctccc agcgggcagg gatctaggca tgccttgctc ataccacaag
155521 gcagaaacac agtgaagaaa gacagagaac tggtcttgtt gtctttgggg gctcagcccc
155581 ccagctccaa gctggaggat caggaggcat ctacaagcct ttccgaagcc cccccatagg
155641 ctgccttgca gggtacagta tggcctagag agccccagag ggctcccctg gtcattaaat
155701 atctcaggat ttccaggaac aaggagaggt tcaagtccac agaagaatct gattggcgtc
155761 tctgggccac ccaccggtgc tagaatcccg gctggggtga gggatggtgg tgcagagcct
155821 ggctatgcaa aatgtggcct ggagcagcct gggggccccc gggagcttgt tagagatgct
155881 gaatccaggc cccatccaga ccagctgaac taaaacctgc attttggcaa gttcccaggt
155941 ggtctgatga cattgaagtc tgggacacac tgctctagac cctcccaggg tccctcaaag
156001 gtgggtgtag aggccctact gccctgccct ggggacgcag aggcatcagg gccttagtcc
156061 tcctggggac agtgaaaggg ccaccacccc agaccatggc caaactgcag gggtcaggga
156121 ggcatggccc aggacagcag ctcagcaggg tgcccaaccc cacctgcccc tgcctgcccc
156181 aacccacttg ccggctgggt cctctggacc tccgcccctt tccaccccag gttggagcca
156241 aagaccaccc tctccactcc ccagcccccc accccccaac ccaccgagtg cagggcccgt
156301 tgactcctat ctcaacaaca acaggaaacc atttttccag acagcattat ataaggggag
156361 gatgcgtatg ttcagcagat gttcactctg aggccgagcc tcccccgccc tctgaacagg
156421 aaggccacgt ccccatccct ctcccccagg gcctggcgct cctggcccag gtggagctgg
156481 cctctggctg gccacttctc tggaagggcc tcgtccagct ctgtcctgtg cagggtcatg
156541 cccctccact ctgctctctc tagcccatgg gcaggcgccg cctggctcag aggcacagca
156601 atgggccagg gtcagacagt ggtgagcagc atgccaagaa tcacagggac atccacctgc
156661 cagcaaagcc tcaatgacaa caaaggacct gaacagtgga cactgacagg gactctcctg
156721 cttgaccaaa ctttagtcca gctcctgaac cttctccttc gcccacttcc ttgtaagatc
156781 cagtttatca agaactctgc taagtcacga atgccccatc tctccatatc tgatcaccct
156841 tgatatctgg tcaggctcgt cctccccatc acccctctgg tgatgtctgg tcaccccagc
156901 ctgtcttcag ctagaatcat gttaggtgag tttagctaga atccccgacc cctgatgttg
156961 ctcttagtaa ttccccatcc cctggcccct accctgctcc ttggctatca ccccccactc
157021 gcccgtgctg tattcggagt tgagcccagt ctctctcccc gactgcaaga gcccactcta
157081 gcggttcctg tgtctatctc catggtcctg aataaagtcc gccttaccgc gctttaataa
157141 gtatcattga atcatttttc atttaacaac actctgcctt gctgaaggga aggtagaaat
157201 gacagcagtg gggaggaggg agaaggggca tgggaaccct gtgccgctaa gggcatactc
157261 tagaccctct gccccaggct aatgttagaa gctgcagagg tgcaaatata acagtcagac
157321 gaccatggca gtggtcagct gaaaaatggc ccccgaagac acgtccgggt cccaatccct
157381 ggaacccata aatgttacct tccatggcaa aaaagaactt tgtagatgcg gtgagtccaa
157441 ggatcctgag atggagtgaσ tgctggattt tccgggtggg cccagggata gacagaatgt
157501 ttatattccc cccaaattcc gatgttgaaa gctactcccc caaggtgata tattaggaag
157561 tggggccttt gggaggtgat tatgtcacca gattccatcc acacgaatgg gatttgtgcc
157621 ccgatcagag ggaccccaga gagctccctc accctttcag catgtgagga tgcaacaaga
157681 tgccttcttg aaccagggag cagaccctca ccacaaccat atgcacagct tccagaaccg
157741 tgagaaataa gcttccgatg cttttaagcc gctccgttta tggtatttgg ctatagcagc
157801 ctgcatggac taagacaggc cctaaatgca atcacacttc tctttatcag aggaaggcag
157861 agcaagatga gccaggcaga ggagaaggcc acgtacaggc agagcagagg gagatggagg
157921 atgtcggccc tgaagcccag agcgaagagg ccacaagcca agcactgctg gctgccacga
157981 ggacctggaa gagcccagga cgcatcctcc cctagaggct ccggagggag cgcggccctg
158041 ccgccacctg cgttttgccc tgttgaaact gatttcagcc tccagaaccg tgagaggata
158101 caattctaat gtttcaaacc agcaagcttg tagtaatttg caggcagcct cagaaaccaa
158161 tacaatgggg aactctgata tggactaaaa gtggtgagag aattatggta gaagaatggg
158221 gctgggaggg gcagcagtgt tgtcagtgag ctaaaccctc ctcttccagg gcaggaagtc
158281 aatggacaac atcgaaaccσ gatacatcaa gaaacagcaa tagaatagca tttcaggact
158341 tcatggcaac cccagaacca gccagcagcc taaagcctta ccggggctcc ctcctcagga
158401 gtggcctgtg aagaggggac gcacacgcat tcacactcat gcacacacac acaccgagac
158461 agaggagggc ctggccagag caggggtgtc agcagagggg acgcacacgc attcacactc
158521 atgcacacac tcacaccgag acagaggagg gcctggccag agcaggggtg tcagcagagg
158581 ggacgcacac gcattcacac tcatgσacac acacactcac atcgagacag aggagggcct
158641 ggccagagca ggggtgtcag cagaggggac gcacacgcat tcacactcat gcacacacac
158701 actcacaccg agacagagga gggcctggcc ggagcagggg tgtccgcaga ggggacgcac
158761 acgcattcac actcgtgcac acacacactc acaccgagac agaggagggc ctggccggag
158821 caggggtgtc agcagagggg acgcacacgc attcacactc atgcacacac acactcacac
158881 cgagacagag gagggcctgg ccggagcagg ggtgtcagca gaggggacgc acacgcattc
158941 acactcgtgc acacacacac tcacaccgag acagaggagg gcctggccgg agcaggggtg 159001 tcagcagagg ggacgcacac gcattcacac tcgtgcacac acacactcac accgagacag
159061 aggagggcct ggccggagca ggggtgtcag ctccaggacc aggagttccc aggcagaacc
159121 tgatggtggg gcggggggtt cctcacacac cccacacccc tgcctatgcc cagacctcca
159181 gcttcgggct ctgcatccac acggaggctt cggattgggc gcagcctggg agcacacaga
159241 ccggccaggg ccagggccag gactggcatt tcccgggctc ctggtcccat cctgcccctc
159301 ccaccgggtc ggccctgtcc ttgtcttgct cagctcgggg gaagcacctc tcgccagcca
159361 tctggggctt ggctgggcct cagcctcctg gctgccacgt ctcactggga gctgggcggc
159421 cgccagctct gagctaagtg agcgcagagg agagtgcagg gagcggcaag gccaggctcc
159481 tccccacccc gtggcgtggc gtggcgtggc cggaatactc agttttccct gctttttgag
159541 acaagagtag taaatgcacc gtgctgtact cagagcccag gaagcagccc tcccacccac
159601 agcgctcctg cctctgcagc cccccgggcc gtgtctctct ctcacgggcc cacatcctca
159661 ctggactgtc tcccttttac agatgaggtg agacagcatg cagaggccca tgtgcttgtc
159721 ccacagggtg acgggccaga attacaagcc cctgattctg ggggcttcca cgctcttcca
159781 ccaagccctt gtagccttcc tgcacccagg tggggctcct gtcccccgcc agtgccccca
159841 acctctactc cagcagacct ccacctacag acaggagtct tgggcacaca cttttttgtg
159901 ccaggcccaa ccaagagctg caagggacat aggaatgtcc cttagcatgg cccgggagcc
159961 tcaagcccag ggcctaccta gaagtaactc tctttcctga cattaagcga ctcccctccc
160021 agagcctaat cacagccagc tacgccccct tctcccagtt attcaagcct ggaaggaacc
160081 tggaagtggt actggattcc tacacccacc ccccccacaa tccccaaggc cccaccccgg
160141 cctcctcctc cccctgcccc tgcatggagc aggcctcact cactctctct cttctgttcc
160201 tcctgggtcc ctgcctcaga ccctcccacc taacacagcc tctgccccac cccagagggc
160261 tcctcccaag acacgcgtcc acgtcgccat ggacaagatt aaataccctg gcttctggaa
160321 agcactgagg ccacagttgg cttctggaaa gcactgaggc cacagttggc ttctggaaag
160381 cactgaggcc acagttggct tctggaaagc actgaggcca cagtgctttg ggaaggtcat
160441 gtcgggatcc cagggctgac tgcactcctg ccagtgaagt gggggtgtcc ccaaaggggg
160501 tttgtttccc accattggga gccaggatcc caggtcagga aacagagctt gggtgggagg
160561 gaagccatct ctggggaσtt tcctcccatc tcccttgtcc cgctcacgag gagaagccag
160621 agctagaagc tggcatgagc cctcctagca ccaccagcca cagtctccac ctccggggac
160681 acgagctggg atctgagtgg cgcaggtact atgttctaga gaggccgtac ccaggaccgc
160741 ccatggcacg cagaggaaaa ctgaaacaac gatccttcca gagacaaagc acagccccag
160801 atggccacag gaactggccg cccccaggag ctgctgagca caaacgccac tggagagagg
160861 gcttggtggc tgcaccgaag agcagaacag aggaactgaa cagccacagc caccgcagaa
160921 ctgggggatc tggacagagc tctcgctgtg tgctaagaaa ggagcaagag acagagggca
160g81 gggagaaaag ctgcgagacg tgggcaagtc ccagaagaga gtcggggagg tgagagaagg
161041 aatatttcaa aaaacaaaat tacatgaaag attccagcat ggatgggttc ctagaggcct
161101 tatcaataca tatataagaa aaagctccat agctagaccc acgataatga aacctaagaa
161161 catcaaagac aaagagaaag ttcaaaagct cccagaggga aagagcagat cagatcagtg
161221 taaacaggga ggcagcaggc agacatccaa gtcccagact ggggcgtggg caccgggcag
161281 cagacgggag acaagagccc aggaagtcct gctggcaaag aattcaaagg ctcttgcctg
161341 gagggaagag gctgccccat tccgaggcca gagccaccgc agcagaggac agctgtgtcc
161401 ctcagagggg tcggcaggga cagaggccac accagagcag cagagatcta gcaacccaga
161461 agggtgacac cctgggagat gctgagagca gcagggccct caggagcagg gctggggagt
161521 cggccacagc tcagggggtc attgcatgtg ggcatcccag gctcctgcct aggcccccta
161581 gggctcccca gccccacaga acaccctccc cactcccagg gatggcattt gagaccttcc
161641 tgctgtgtcc ctccaggaac ctgtgagctc caagagaaca gaaggctgcc tcttcaaccc
161701 cagtccagca aggcccaggg cagagcaggc acggagaact gctgtcgaac atgaagtggg
161761 gacgggacgc agtggtgtac acctataatt ccagcacttt gggaggccaa gaaccgctta
161821 agtccagaag ttcaagatca gcctgggcaa catagtgaga ccccatctct acaaaaaata
161881 aatttaaaaa attagccagg catggtggtg cacacctgta ctttcagcta ctttggaggc
161941 tgaggcagga ggatcccatg aaccaggagg tcaaggttgc agggagctac gattgcacca
162001 ctgccttcta gcccgggaga gagcaagacc ctgtctcaaa aaaaggaaat atatttaatt
162061 ttttaaaaag aatacacagt ggtgagaaag gatggaaaga agagaggaaa ggaaggaaag
162121 gatagggaaa gaacaaaaga aggaaagaaa gaaattccag ctaattctca gcaacagaca
162181 attacaggaa cacaaggaca aagcccagag ccccaacccc acgtggcctg ggtccccaca
162241 gcctccagcc ctcctgtcac tctgccagct ggcagcaggg ccacctctga gcatcctttt
162301 cctcagcact ttggcgtctt tcctcccagt ggtttcttgg tagttcctca taaatccatg
162361 cgtaggtctg gctacagcta tccttgtccc tgaagatgga ctcagctagc agagtcgctg
162421 atatggtaac acaatatcac acatctcatc caagcctgct cggacgctgc ccttctgacc
162481 ccgattcctg tcaccaacac aacaggaaag gagcttgaag acccaggagg ccacagcaca
162541 gttcctcgtg gagggagaga gatgcgagca ggtgggcgga gggtgcactc atgagacttc
162601 tataagcacg gacccagagg ccatcccagc gacactgtgt ggggactcct gcacctcttc
162661 ctgctgccca gaccatgggt ggccagcagc actgcagtgt tggtgtaatc tatgtccccc
162721 ggatggccag cgggcacaga gcatatgtgt gctgagggac acatgcccca cacaaacgcc
162781 cccacatgtg catcgcatac atcacccaca cacacacgtg tacatttcag cacgcgtcta
162841 ggggaggtta gcgtgccagc accagctgag actccctggc cagactcatc gccagttggg 162901 gagagtggag cagacgtaca ggatggaggg tagaggtggg gctggtccac agtgagggag
162961 ggaggcaggt gtagactggg ccagggaaag gttctggaaa cccagactga aggttccctg
163021 gggtccctgg ggctcatcca gggctggggt ggagccagga catgaggaac gggcagtgat
163081 gaatctgaag ccctgctggt cagcagagcc tccacctgca cgtcctcccc aaaggtcagg
163141 caggcttcac cctggccacg tctctaccct ggccattagc aaagaggccc cccttggacc
163201 aggaggaaca cagcaggcca gccctcctgc ccttcccatc caaggctcca gccactctca
163261 tggagactct gagctgagac actcccagca gaaagggtca tttatctcag agcttaacta
163321 gccccttcca attagtgagg aataaaatgg cagcatttac tctgaagaac tgcgatgcga
163381 gagtattaat taaatgcgct gccgctgagc ctcagcacac aggaggctga gccctcatta
163441 aaaaggcatg agactaaagc aagacaggga ggagaggcgg ggccagctag acaggggatg
163501 gggagagaag gagatgccgg gcggggcggg gacagccagg gacggccaca gctgccctgc
163561 caggagggac agggcccact gcaaagtggg acagctgctt ctagccctct cacaagaagg
163621 ctggtgggga agaagccaag cacacgcaga gggtgctccc gcacacccct cgcctccgtc
163681 tttttggaat cttgacagtt agaagacgac aagggccact gtccagtggc tggcatttgt
163741 ccccatgaga ccacagagag gcagaggaca gctccttctc agaccagggc aggtggggca
163801 atgccaaggc cccctcggct caggatggag ctgagcctcc ccaggatgac tcccctgggg
163861 gaaacactga tgtcgctgtt tgagcgttga gacgttgggg cctggcctct gagaggcggg
163921 gccccgaagg gtcttccagg aaggtcagac cccagcccaa aagcagcagg cctgggccac
163981 aaagagagct ggtccctggg ccagaaagcc ctcttccacc atgcactctg ggcaaggggc
164041 gtgtgtgcca ttaggaacac agctgcacgc tatttctctc ctgtcttcct ccagctgaag
164101 atttcacaca gccσtgttat gactgagggt tcccaacagc tattccctca acacacaggc
164161 ccccacacac atgcatgtgc actcatgcac tcccacatgc agcatgcatg cacccacata
164221 caaatgtcca tacgcatcac atgcaccacg tgtgcactca cacgcaggcg tcacacaggc
164281 accatgcaga cgcatgcaca cacacatcac tcatatgtgc atctcctgtg acacatgcat
164341 cacatacaca tgtccacaca tgtgcactac acacaagtac acacatgcac cagaaaaatg
164401 ccccatgcat gtgcatggca gacattaccc acacatacac atgtgcatcg gtcatacatg
164461 tgtatcatat gcaggtatca tatgtacagg catgcagtgc acacatgcat gcatcaagca
164521 catgcattat acatgcacac gcccgcacat gtgcacacat gcatgacact catgcactca
164581 cacatgcctc acatttgcac acatgcatca ctgacgtgct cacacatcag ccacacacat
164641 gcactcactc acaccctcct gctgctccca gcctcactgc ctgcttgctt actttcccag
164701 ttcctgccac tacctgagaa ggtgtttatt tggccttttg cttattgtat gtctctacca
164761 cctcatccta cccctcccag ccctccccat ccacactcaa ccagtagaat agaagcctct
164821 cccctctgtt gaggcaaaaa gctgtgaccc tcttttcacc cagaaaccac aggaagcatg
164881 cgtgcagact ggactcagcc ttcaccagcc cccgcagtca ttacgcctgg ctccccagca
164g41 cccaaaccca ggtccccact ggtcagcacg ttcacaccca gcctgccaca tctccggcct
165001 ggcccacaga atgcctggtc ccagactcct aatgtaggaa gactgccctg cctgatctca
165061 aggcttgctt ctctgcattc aggccactcc tgctgcccag cctgacggct cccggagcag
165121 ccggtgatca gtcaacctcc ccagccttct gtttgccttg cagagccagc cgactcccag
165181 gagagctgta gaggctggtc agcagcctca ctgtccctgc cctgcctggt gagggaaggg
165241 aggccacgga ggaaattccc tcccgctcca tgtctgcctc gtgtccttct ctctcctgct
165301 gtgctcctgg gcagcagctc cctcctccag ccttccaggt ctcccaatcc tggccccagc
165361 cacttccttg ggaaccctaa gcctgcctgg agtccaccct cctccatttt tttgggtttt
165421 ttttgagacg gagtctcgct ctgtcactca ggctggagtg cagtggcacg atcttgactc
165481 actgcgagct ccacctcctg ggttcacacc attttcctgc ctcagcctcc tgagtagctg
165541 agactacagg tgtccaccac tacgcctggc taattttttt tttttttttt tgtattttta
165601 gtagagacga ggtttcacca ttttagccag gatggtctca atctcctgac cttgtgatcc
165661 gtccacctca gcctcccaaa gtgctgggat tacaggcatg agccactgtt tctggcccac
165721 ccttctcctt ctgatagcac agcccctgtg tcactcagga accagctctc atccctgcgt
165781 caccagtggg caaggagggc acatgaccca gcctaggcca ggtagaatac gttgtcatct
165841 gactacatga acatagctca gggatgagga cttgccacaa ggtattccat gaagttaaat
165901 ccaggaacta ttgctggaat tgttggaaag gaaaagctgt ttcccccggg ttgttgccct
165961 gtgaggaggt aatgcagcag ctgcctgcat ccatttttct gcctcagaga agagcaggcc
166021 tgagagtgaa atcgacatag aggagagcaa agccaagggt tggggatgtg ggaaaaaaaa
166081 caactgaaaa tttatttggg cacctggatc cagccacacc tgaagctaga tagttctaga
166141 tatttttctt tttgcagatt aaccaataag tttttttttc ttttttctga agccactttt
166201 acttggattt ccaacacttg aggaataaca cctgactaat acactctctc ttctatagct
166261 tcaaactctc catctcccgg atcctcatcc tcggtccctg agcaaactca agccacctaa
166321 aatcctctgt gctcgaggca gggccacaca cacatctaca caagcgcaca cgtaaacact
166381 gcactcacat ctaagactgc acaccctccg cagctgatgt ctgccccacc acagcatgtg
166441 tgccatgcgc accagcttcc ctccactccc ttgcctctca ctggcccctc acctggtcag
166501 tctagcttcc accaactccc cagcgaccct gcaaagcccc ctcttggctg ctgggcctga
166561 tgccccctgc catcccaatt ccctgaaccc cctcctcttg aacctctctc atcctttagc
166621 aggtgggcag ccccgctcct aagaccccac tgcctcctcc acttgtctgc acatggtggg
166681 gggccaagga gcacttcctt ccccttctgc ctccctcttc ctttggtgcc cgcccaccca
166741 ccccaggatg tggaatccac agccctccat acagagcgct cccaacccga attctaccca 166801 gaccttgccc ctgcacctag gacctgcatt tccagctgcc agactccttc caagagacag
166861 ccccagtgac aaaccctctc tccaagctac ccttcctctc taccacccat ctgtgcaagt
166921 caaaagctgg ggagtgcttt tcctcagcct ctccctcagc ccccaggccc acagacccaa
166981 gtgcctggag atcccggcct ctccatgttt cctgagtaga ttatgctgcc tctattgaaa
167041 gatgttccgg cagaacactg gatgatccag aaatatttcc attatgtgtg gcatgggcag
167101 aggcagatca caaagggaag gtacaatacg acccttttgt cattaagtat gtttacacat
167161 atgtgcatgg acgtgggaga cacacaaaaa tgttgaaagc taatggcact gcagggattt
167221 ccattttctc cttttggctt atttctgcat tctgttttat atgaaggcac atacgacagt
167281 ttttaactta aagacaggac aaaaagttgc cagccatcgt gagtcacccc aggactgccg
167341 gtgctgggaa tgccaaaatc tgatgggacc cagcgcaggt ggggagagga gcagaggatg
167401 cacccacggc ccgtgccttc tttgaatcag tcctcacggg gccatctcaa ggtggagact
167461 ctgaaagtgc agagaagtga aataacccgc ccatggtcac acaggaggga gtgcagggtc
167521 cagttctccc tcccccaccc aggtccgcac tacaggctct gatccacgcc ctcccttgag
167581 gacaaaccct gagccacgct gggtcctccc gcaggccctg aaatagagct tcattgccac
167641 atcagacacc gggagacgcg aggaggccgt gagccaattc cagatgactt gtcaaggctg
167701 cgccagccac agagtcaggg aagcctctgg ctgcctctgt aatataagaa ccaggactga
167761 aggcccctct gggagggcac tagacgaggg cctcggcagc tccgcaggca ggtggggccc
167821 aggccaggcg ggacagaaac ccaaatgtgg cgatgcaaac tggacagaaa gaggcctctc
167881 tgggctgcgg ctccctcaσt cggggcctga cggtaccagg gggagttaat ctctcacaca
167941 caagctggcg ccagacccct aactgcaggt gtccctaagg agaggtgcct ggcaagtcct
168001 ctcctgggag tggacgctct cctcctgagc acggtgtgga agcagggccg tgcccagcat
168061 gggtgcgtga ggactggatc ctgcctgcag acaggactgg cgggaggcag aacttgagct
168121 gcctaggact gaggccactc cagagccaag actgacagtc tccacaaaac caaggagccc
168181 tcacctgtct catggctggc aggggctgca caggaagtga cagaggcctg gtgccctcga
168241 gaggcaggca ccgagccagc cagtgtcagg gagcaggtct gcacatctga tggaaaatcc
168301 atccgtggtc ccccttctga caggcctttg gctgccttcc cttctaaata gctgcgaagg
168361 gaaatggcct ggcagaagga aagacaatgg ggccccaggg gcagcagtcc aggagggcct
168421 gggcccccca ccctccagct gtaggactcc caagctaagg acagagagaa tactttgggg
168481 aggagaaaga agcagacacc aggcttcgtg gcaggtgtca gcatggctga gggcaggcag
168541 aacagccgcc agcttgatct ggacacctgg tcctgccaca ggccacagca cttgccaggg
168601 gccgttggga cctgtcactg ccctgtggga gctccctgga gagttcttaa cctgggctcc
168661 ataaactggg aaaagagaac acttcaactt catctttact aactgggaac tgaaagctgc
168721 cattcccttc aactctggag agaggcagca accccagact taacagcacc tgcgcccgtc
168781 agggcagaaa tcacaggctt cggcaactgt cagcaccgct gctgcagacc agaccaaatg
168841 gtgtttacac tcagcacaac ttaaattata gaggctgtaa gatgcactcc taggtcttat
168901 tatttaatgc atcaattaaa agcacacaaa aaagttttac atgaatgttc ctggcagcat
168961 tattcacaag agctaaaggg tggaaacaac ccaatccatc aacccatgag tggatttaaa
169021 aaactgtggt acatccatgc aatggaatca tatctttcca tccaaagtaa tgaagctctg
169081 atgcatgctg caacctagat gaaccttgaa aacattatgc tgagtgaaag aagccagaca
169141 caaagggcaa atattgtgtg attcatttat actaatgaaa tgcccagaac aggcaaatct
169201 atacaggcag aaggtaggtc agtggttgcc taggcctggg aggacggggt aattgggggt
169261 tactaaaggg tctggggttt cttttcagag tcttgaacat gatctaaaat tgtggtgatg
169321 gttgcaccat tctgtgaaca tactaaagcc attcattgaa ttttacgtta taagttggta
169381 aaatacatag tatgtgaatt atgtctcaat aacattatta tcaaaaatgt gtaaggtata
169441 ataatgatta aaaattttaa aagcatgtgt atgttgatag ctttattttt ctcttttttt
169501 ttttttttga gacagagtct cactctatag ccccaactgg agtgcagtgg tgcgatctca
169561 gctcactgca acctccacct ccagggttca aacaattctc gtgcctcagc ctcctgaata
169621 gttggaacta cagatgcccg ccaccacgcc cggctagttc cttgtatttt agtagaggca
169681 gggtttcacc atgttgccca gggtggtctc aaactcctga gctcaggcca tcctcctgcc
169741 ttggcctccc aaagtgctgg gattataggc gtgaggcacc atgcctggcc gatagcttta
169801 tttcaatcag atttatttcc tttgtatttt gtagtgtaca ctaaacacat tattttgatc
169861 aggggtccat gggcctcacc aggctggcag gagggttcac gacatggaac agctgtgcta
169921 actaccagga cagaagacag gaaggtttgc tggaagaggg gtgatgagaa gttggccagg
169981 cctatggggt tcccagcatt caggcaaaag cccagaggtc ctcagggacc cccccactgt
170041 ctgctctgct aatgcaaagc ccatgaggcc caaggagtct cagcttcttc agccacccga
170101 tcacaccccg acacacacta ggccctggtt ccttcaagtc cttaggtcat tttcagattc
170161 aacttcagcc aagacaaatg gtcccctcct gcacctgcca caggcactgt ttccaacgtg
170221 ggcagagttg acagttgatg ggtgtgtgtg atctttcgga gctcctgtcc caggcccaca
170281 ggatgaacgg gaaggtggac atggtgggta gagcaagcag gaaatgatga tggtcaggag
170341 gggccttgaa tgctggttct gggggcctgt gctttaccct caaagtggag gagccatggg
170401 gagcatttcg ggtggggcac ggaagggaga ccgcgtgctt atcatgggca gctggaaggg
170461 agtgggagaa acgggggcag ggagaagaca gggcagatgt cctggagaca gaaggcaatg
170521 gggacccata gctcctcctg acacatcagc ctggctttcc tctggggccc atcctctccc
170581 cgacccactc ccagagggtc agaggacaga cgccagccct ggagccacag cagtcctgtg
170641 acgaggcctg gccagccgaa gtcctgctcc gctgtcctgg ccatagtgat ttgcctgaag 170701 catgtgaccc aacctgagcc agtgagaact caccactggg ctctcccaga aaccctcggg
170761 gaacctgggc ctctctctgc cgggcggctg gtgcactgcc caggcaggac ccacggggag
170821 ggcggctgag ctgaaaccgt gcgggaggcc tgggctgccg ccctgagccc cgcattcccc
170881 ctttggcccc agccgcttct gccccggttt tctgtcactt gcagtcacag gagtgtggac
170941 ctggggatgg cctgtgggag ggacaggggc acaggcacca gctgcacagg tgtggatggg
171001 aggacaggag cgaggccagc cgcctctggg ccacaccctc cggattcact cccaaaggag
171061 aacggccagg cggccaagtc ctcccagctg aggggtgcgg aggaagggat cagagcgctc
171121 ccccaacaaa ggctgcctct ccgtcctgca catcccctcg ccacactgac ctccatttcc
171181 cttcttgggg cctgcccgcc acgagactct tctcccattc cagactggaa atcttttccg
171241 caccttgact aattgttttc aggtgggaag gatttggtgg agaaatggcg tttgtgtgtg
171301 cgtgtgtgtg tgtgtgtgtg tgtgtgtgtc cacccccagc cgggcagctg ccccaggaat
171361 gctgtattgg cgggaagagc tagaggaccc ttggcctcag ccatgtcctg aggggctctc
171421 ggtgatgtca gcggctcctg gcctcttcca gtaaacatct gttcttattc tgacccagga
171481 attccatttc agaacagtaa cggcctccac tggcaacaca tcccaggccg gtgatgcctg
171541 gggcagggag agcatcctac cccggcctgt gccccgcccc cggccccgcc ccccactccc
171601 atgcccgccc aagccccgcc cacagagctc tcaaaaggga caaaatctgc acctggctcc
171661 gtgtgtccaa gcgctttcac actgtggtcc ctcctagcag cgccatcagg aaaatatgat
171721 cttgtagtaa caggcccttc gctgctcagt gctggccctc gcttcattta atcctcatca
171781 taacccacca gagtagttac cgtcatcagc ttttaccttt cacagatgag aaacaggagg
171841 ctcgctcgcc cagggaggga gggagcagaa aaccaagccc acgtgttgga gcgagatcgc
171901 gtctgactcc agcgcacggg accttgcagg ggctgatggc caaaaactga agtcatggga
171961 aggagaggga gagggagagg gagagagagg ggaggaagaa atgaccgttc caaagcccat
172021 gcagcactca tctcaaaata agagaaactc tcaggtgcct acacagggag tgaatgcgcg
172081 tgaagcccgc cagggtaatg atagggagca gcagagactc ccaaggcacc tggaactgtg
172141 ggacccttct agagggttcc atccttgctc agctctagcc ctccagcaca taggcccggc
172201 agatttcctg gttctcaaga gaaactggaa atcttgagct ttgtgagaaa ttttcaaaca
172261 ctggaaaagc caaacaaaac tcatctgtgg gtggacatgg cccgtggccc accagtgtgc
172321 aaactccgcc ctgcacaatg ggaaccctga agtgcagaaa attatctcat tgtgaagggt
172381 aaggcaggga ctcaaaacag ggctcctcag tccacattca tagagtctcc aggttgtacc
172441 accgaatcta ctcgccagcc ttctcctgaa agtgtctcac tgaaccacat cccccgtaga
172501 aactcagggc atctttcaaa gaccgcagtt ttcctgccag cctgcaaaca accctgtgca
172561 tgcccggtgc actgctcccc aaccacaggg gacacctaac agaccacgag ggactgagag
172621 agcctccttg actgaaaggg aaggtcaacc gccgccactc atccccataa aaccacaaca
172681 tgggcacatc ctgcgttcga agctctactt gatgcaagag agcagggaaa ggaaagccgt
172741 gccaccgtgg ggaaatgggc ctgggagatc cattcaggcc aaggtttgtc cactttgggt
172801 ctaccaccac cagcattcac agaagaagca gcacctggtt ctcaattccc ttagaagcgg
172861 ggctagatgc tctgaaggca tggttgtagc tcccacacaa aattactaaa gacataaaac
172921 gaaaacatgt tgaaaaagaa gagacaatat tatgaactgc agaaagtaac tgcacacgta
172g81 gagaatcctc acccccaaaa acatccaaaa aaaggaacca aataataaca aggaagttca
173041 taaaaagtct agatgcaaaa taaatagaga aactcatata tctgggaacg caaacatggg
173101 aaacatccaa gcgagagatt taggtttgtt ttgttttgtt ttttgagaca gagtctcgct
173161 ctgtcgccca ggctggagtg cagtggtgca agcgatctga gctcactgca ggctccgcct
173221 cccgggttca cgccattctc Gtgcctcagc ctcccgagta gctgggacta caggcgcgca
173281 ccaccacgcc cggctaattt tttgtatttt tagtagagac ggggtttcac cgtgttagcc
173341 aggatggtct cgatttcctg acctcgtgat ccacccgcct cggcctccca aagtgctggg
173401 attgcaggcg tgagccaccg cacccggcaa gagatttatt tcagaaggac tttttgtgat
173461 tatctgtggt tcatatttgt gccattctag taacagagag actgctttgc taagacatgg
173521 gaagatgcag gtcattggga gcaaaggatc tgaagcaggg gctgttgcca ggaagggcgc
173581 gccttgagga cagcaatgct ggggcttggg cttgccaggt caaccatggg tatcaagtgg
173641 ttcgtggcag ctctgcacat gcatgtatga tttgcactaa tgtgtcattt ttaactctgt
173701 tttctccctg ggaataaaga tgtctaaatt ctgagaatat cattagtctg aaagaagcag
173761 gtcccaggta ttctgagtaa ataatcacct actgtattat aaattaaaag tgttcccaga
173821 taacaatctg gtgtaaaata taatggaaaa gaccctattg acaatggcaa taacattcta
173881 agtctcttag taataaacct actgggctat gtttttaaac atctgaatca atcttcttat
173941 ttccgtgaga aaattaaaca tcatgaagat gtcgttcatt tgttcagcaa agatttgctg
174001 agggccttct gcaaagggga cactacttta ggcatttttt taaaacctca cgatggtgat
174061 acttgcccta tcagatgtca gaacatattg tcaaccaaca gcaattaaag acccctggac
174121 tggtgcaaaa gaaaaacaga aaaggccagg cacagtggct catgcctgca atcccagcac
174181 tttgggaggc caaggagggc ggatcacgag gtcaggagat ggagaccatc ctggctaaca
174241 cggtgaaacc ccgtctctac taaaaataca aaaaattagc cgggtgtggt ggcgggcgcc
174301 tgtagtccca gctactcttg aggctgaagc aggagaatcg cttgaaccca ggaggcagag
174361 cttgcagtga gccgagatag tgccactgcg ctccagcctg ggcaacagag tgagactccg
174421 tctcaaaaaa aaaaaaaaaa acaaaacaaa acccagaaag gccagaaata aaccccatat
174481 cctccatgaa cttcacagat gatggaatat acattccaaa gtcaagaaga aagagtgaat
174541 tagcaaacga atggtgttga gacaacagca tggcaattta gaaaaaaatg aacacttaaa 174601 accaacacct tatacagtat aagaaacaca tttcacttga attaaaggag ttacatattt
174661 aaaaatcaag tcaggaaaaa agcaaaacat ataatggagt atttctttga aaggctgata
174721 cttttctaca ggctgagtaa ccagaagaaa gcaactagag aggctgacag agctgaccga
174781 agaaacaaaa caccagcccg gcagaataaa aaaggaagct ctgcaaatat aaacccaccc
174841 aagctagcag agggttaatg actagcccca gggagaacca atcagcttca gaggaggaaa
174901 gttgggggcc gtaaccacca gccattaaag aaacaagttt caggccgggc gtggtggctc
174961 acgcctgtaa tcccagcact ttgggaggcc gaggcgggtg gatcatgagg tcaggagatc
175021 gagaccatcc tggctaacaa ggtgaaaccc cgtctctact aaaaatacaa aaaattagcc
175081 gggcgcggtg gcgggcgcct gtagtcccag ctactcggga ggctgaggca ggagaatggc
175141 gtgaacccgg gaagcggagc ttgcagtgag ccgagattgc gccactgcag tccgcagtcc
175201 ggcctgggcg acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aggaaacaag
175261 tttcaacaat aacacgattg cctgactccc accaagggtc ccaggccagc ccagccccag
175321 cggactcctg caggccttgg ggagccaggt gggcacctgc aggcaggttg ggggaaggct
175381 gtgaggactc tgagccccca gagtctatca ggacaggctg acaccaagac agagacggcc
175441 tacatctacc caccccatac catgcccagt cctggaccag ccatccctgg ccccaaaggc
175501 cacagcgtag tcaccacagc tgagactgcc ccaatcaggg ccacctgcaa tgtccagcag
175561 cctccctgca actgccccgg ctttggtttt taatgtccct agtcccgaga atgcagaagc
175621 tctgcaaaga gaagaacgca gcaactctgg caacctgact gtggaggcag acacctggca
175681 cacatttccc ctcccccagt gcccgtgatc tccacccagc gctgggcacc ctccaacctc
175741 cactccattc actcccagac ggagcaaagg ctggcctcat tggccacctt gcccagcaca
175801 ccacctgcac aaccttccca gcagccctgc tcatcgggcc accctcccca gtgaggacac
175861 agcccgtgac agcctgggca ccccaacagg aaagacagcc caaaggccaa gccgccctat
175921 ctgaggtgga ggatgctctg gcagggcagg gactcagcct tgaccttgtt tgctagaaaa
175981 tgcaccaaga actcagtagc aggccaagga gaggagacat gaattcccct tttcagcaat
176041 tcaccctgct tgtacaggtg gggagttatc tgtacctctg aggaggtaca gatttcatct
176101 ggtgctccag ctgcagtgaa aggagctggc tctgggctct gtgggacctg gggtgggtca
176161 tccccatcgc tgtgccctga tttcctccca gcacattggg atggctcgtt gttggttccc
176221 agaatgtacc aggaaggtac aggtgcagag tgcagctgac gacgaagggc ccccagccag
176281 gaagggtccc caggagtcct ggctgatgaa agactctggg aaagaaaggt gggaacaggg
176341 agaggacaga aggggcaggg aggggagagg acataaaggg agaatggaga gaaaagggaa
176401 aaaggggaga tgagggagaa gagaagggag gggagtggga aaaagaggaa tgagaaaaga
176461 agggggaaga gagaggaggg aaggggagga gaagctggag ggagaggagg gggaagggag 176521 ggagaggagg gggaagggag ggagaggagg gggaagggag ggagaggagg gggaagggag
176581 ggagaggagg gggaagggag ggagaggagg gggaagggag ggagaggagg gggaagggag 176641 ggagaggagg gggaagggag ggagaggagg gggaagggag ggagaggagg gggaagggag 176701 ggagaggagg gggaagggag ggagaggagg gggaagggag ggaggggctc ccagcaccag 176761 gacccagcac aaccgtccta tgacagttgt ctctgcagct gcatttaggg ctgttctgga 176821 aactcaggcc ttctccctgt cggcagggct gagccctggt ctgggacctc cccttgttct 176881 atcagagccc ccaggctggg tgaggtccac tgggatctgt tttcactcac aatgcttctg 176941 acaccaaaca tgtggtttcc ctcacaccaa ccagttctcc aacctccaga cgctagctgg 177001 gtgccccaca gttgagtgca atgctcacgc caactacctg gggtcagctt agccctcagg 177061 ttaaggcctc agtcccacac agcagcccca cttgcggtgg caagttccag ctttccacct 177121 gtgcctctga ccaggcggct ataaattggg cgggtcccac aactccctcc tcaggttctg 177181 taatttgcta ttaggttggt gcaaaagtaa ctgtgacctt ggaatcagac agacatgtgt 177241 tcattaatag aacagatcac agaactcagg gaggcatttt acttactatt tccagttgat 177301 tattaaagac acaacccagg aacagctgca tgggagggat gggcagggca aggtaacggg 177361 aagggctgca gagcctccac gccctctctg ggcactcacc ctcccagaac ctccacctgt 177421 tcaccaaccc aaagctctcc aaaccttgtc atttaggggt tttcatggaa gttccatgac 177481 tcccatcccc agaggttggg gaagtgaggc tgaattctca acccaacaat ccagaaactc 177541 ttatatcagg aacaagggga ctcagaccaa atctgataat aaaaggtgtt tctatcaccc 177601 ttaacactca ggaaattaca aaggttttag gagctctgag gcaggaacca gagatgaaga 177661 acaaacatac atttataatt tcccactatc acagggtctc agacagtacc tcagtctgtg 177721 acccaacctg cattgcccca gaagcccaga cctcagctca gggccagtgt gctgggatca 177781 gtggccagtg gccagccatc gtgcagagag gggagggcag aggggaggga gggaggggat 177841 gggagaggaa gggagggagg agtgcagaga ggaagggagg ggaaggaagg gaaggagagg 177901 agaccaggag cctcccaggg cctgggcacc tgcctgggag ggcactgagg agcaccaagg 177961 aggatgccta ccactgcccc caccttgccc tgatcaggtc tgcaggatca gtgctcaacg 178021 cccatggagc tccaggtggc cgccaagtgt ggacagccct gcagcaaagg ccagctactg 178081 ccctgggagc cctcaccccc ttatcctgcc cgcttgcctg tgaggacccc tccctactgt 178141 gtggccttgg ggatagccat gcgacggcgg ctgccttcct tctgccgggg ctctgaattt 178201 ccaggtgaga gacccgagag cagagggcca ggagccgaca ccgctgtggc agcttcccgc 178261 atcccaagcc gggccatgcc cactggccat cgcttccttc cacctcaagc cccccatgga 178321 attccctttg actgaggcca gccagcctca tccccctctg ctccctcact gacacacacc 178381 ttgtgaggca ggtggtgtct taactgggaa aatggagggt cacaggccag caagagaaga 178441 gccaggcccc aagtctggtc tgtgagcccc cactccccac agccctcgct agtgagcacc 1785 OI cgtcatgctg tacaaaagac tctcctgtgt agcttttgaa aagtacagac cccagggctc
178561 acgcaggtct gataaagcag aatctctcag gatggggcct atgtacagat gctgtgcaaa
178621 gctcctcaaa tcccatgccc atcagtgggc aggσagagag atcacacaat ggaaatgctc
178681 ttctgcaaga caagccacag atttggtttt tttσtgtttt tttttttttt ttttttttta
178741 gacagagtct cactctgctg cttggctgga gtgcagtggc gcaatttcag ctcactgcaa
1788 OI gctccgcctc ctgggttcaa gagattctcc tgcctcagcc tcccaagtag ctgggactac
178861 aggcgtgtgc caccatgccc agctaatttt tgtattttta atggagatgg ggtttcacca 178921 tattggccag gctggtctca aacacctgac ctcaagtgat ctgcccgcct cagcctcctc
178981 aagttacaca ggcgtgagcc actgtgcccc gcctacagat ttcttctaag gagggaaatg 179041 tctttgcttg gaaaaacacc ttctagaagc acgtgggata acagataaca gtgggactgg 1791 OI aagagcagga gactctgcag acagtgccac cacctcagag cagcgggcaa agtccgctgt 179161 taagacacag gaggagaatg gagggattgc tccagagaaa ctggacagag ggagggagac 179221 gccactggga gggaagaaag aacccacaga tgaaagtgga aatgccccca cacatggccc
179281 aaagggcttt ccaagaacag ggtcctgttc ttccagaagt cacccgcgtg gccgggaggt
179341 gctggctccc ccaccttctg caggaaggct gcccctccct acgagggctt cccatggtgc 1794 OI gtaaatgggg actgggtttc attcctggcc cagcaaagtg gacagctgag gccgaggctg
179461 agaacacaaa caccccggaa tcgcaacacc tctggctttt ggaggtgaga gaagggagcg 179521 ttaagagtta agacacattt tatcttgatt tcagctcctt tactgataaa aatgggatct
179581 tagaaaacga gaattcagag gatattgcct tcacatgaaa tccatcttaa tccacagcaa 179641 gcgctgtatt aagcagagaa ataccggggg cgttgccgtt aaagccaggc acagatgagg 1797 OI atgcgtgtag ccacggctgt gacttaacat cgctctgaag gttccagacg gtgcagattg
179761 gagatgagga tccaaaatta tcagtgttta cagagtgcaa ctgtatacct agaaaaccca
179821 agggactcca caaagatata ttagaattaa tgagttcaat caagctgctt gataaaagat 179881 agttctataa aaatcagtag ccttcctgtg taccaataga tggaaagtat tcaatgagca 179941 atggcaaaaa gaaaaaaaat ccttgaaata atcctgattt ttaaaaatgg atgacctgta 180001 taaaaatatg tatatataat acttcatggt acaacatcaa agcagaatga aataagctga 180061 aaaaatatac tatgttcctg atgaatactg taaattatgt caattcctcc tttaattagt 180121 ttctaagttt aatttactat caatcaaatt cacgagggat ttttctaccc gacaaaacaa 180181 ttataaaatt catttgaaag aataaacata tgtgaccagc caagaaaatt ttgtaagaga
180241 ataccagcaa agggggacgt atccagccag atgttccaaa gccacacagt ccaacagaaa
1803 OI tagaactcga gctttatatg tagccatgtt tttaaaaaaa aaagacacag gtgaaattaa
180361 tttcagaaat atattttatt taacccagta tgcccaaaat attaccattt caacctgtaa
180421 tcaatacttt aaaatgatct attaaacatt ccacattctt tttggggggt acgaagtctc
180481 tgaaatccaa tgtatatttt atactcaggg tacctctcaa ttcagaccag acacatttta
180541 agtcttcaat agccttgtgt ggcttatagc tactgtattg gacagcaaag cttcaaagta
180601 cttaatactt tgactattag agccttacag ttctaataat aaacacagct taatattggt
180661 acaagaacag aaagatggaa aagtagaatg tatctgcggt actgcttaac ctgaggtttc
180721 atttgcaact gactggcgat ggtgtactat aacccataaa atagacagat gtaaatacat
180781 accaatatgc tcacagctct caagcccctt ttcatcatat gtccagaagc tctgtcccaa
180841 tcagaatggc cactagcaag ccttagacaa gccttgcatg aaacgtgaag acaccctact
180901 ttccatgtgc tcccaatccc tgctttcaaa cagccgcgtg ggagggatgg gcagggcaag
180961 gtaacgggaa gggctgcaga gcctccacgc cctctctggg cactcaccct cccagcacct
181021 cacctgttca ccaacccaaa gctctccaaa ccttgtcgtt taggggtttt caaaggaaaa 181081 atacccgggt gtaaagatga caggctttaa cacttggaaa tacttttaat acattgaaat 181141 ttcagattag ggctttcaaa ggaaaaatac ccaggtttaa agatgaatcc cggacattct 181201 gcacagagct ggtgagggct ggtccctcca acacgcatct ttccatttcc caacccctga
181261 actgaggatg caatcggcgg gtctcaggcc ccggccctgg cccccgcctc ctgggccacg
181321 acacttccaa cgcagtccct cactgtcaac accctggaca ctcaaaatgt ctttgaagag
181381 tcacgctgtg aggtcaaaaa gttagggtgc acgcagaaag gcgcatgtag ctttgcattg
181441 gtgaggcaaa tacctatccc tggaggaagg accgctactt cgtaattcac aagaggaaga
181501 cccccggagg cggacgaagc caaccgaact cagttcccgg gagccgtgac aagcgacggc
181561 caggcagcag aaatggccca cccattaggc tgcagacagc atcagagaaa ccaagcactg
181621 tggcagtggg gcccgcgcct ccagggaacc acaaggcaca gagttgcagt ttaaatggga 181681 gtgtctcctc tttcttggtg gcgtataaag taatggtgtg tcctgtaacc gatggcacct 181741 tagagctaat gatatgcaga cacggccacc gctttctcac ccccgggcct ggggtaggcg 181801 cttgctgcac acccaccctt tcactgccac tgaagtgcgt gcggacagaa cccatctttt
181861 gctattggag gaactaaggt tctcaggatc gtggtgcttg tccgccctgc cggtcacgag 181921 gagcacagcg gaccatgtga cccgcaacag cctccagccc acaataggcc cctgccttcc
181981 ctgggttaac ccgtgaaatg cacaaggcag ggtggggatg gcgtagagcc tgcctggctt
182041 cagcagcacc caggccttgg tcctggacac tagggttccc tgtgcctctg agcggaagct 182101 gtgcacccca ctctgcagcc ctggagtcgt cgtgcagtgt aattgaaatt catggacaag 182161 cccgaggagc cagctccggg ctcggtaata acttctccat attaatggca gcaccgcaga 182221 ccctgtggac agctgatatt taatatgaaa catacgcagc agagtgtgca gctcctacct
182281 ggatcctccc attccggggt aaccaccagt aggggatggg ggtgtctaac gtggcgccaa
182341 gattgagggg gctggggtcc tcctctcccc tgagtacctc aaccccactt aaggcccctc 182401 ttctacagag tgcaggaaac ccctcccgag aaatacataa acacatgctg gcccatgctc 182461 actcaaatgc acaccctccc atgcagacac actcatgtgc acacacgtgt acacactcat 182521 tcagacgtgc acaaacatat gcacccccac acgcacactg catgcacgta ctcctacatg 182581 caagacatgc agaggcaaca cgtacatgca cacactcccg ccatgcacag gcccaggaca 182641 cgcacacgtc cacatgcagc caccagcctg ctgtgccggc agcaacacag ggacccccag 182701 ggctgcccaa gccagagagg caggtggggt aaagaaggac atgtctgcct gccagcacag 182761 acccagggtc ccaggagggc tgccatgcac acttgcctct ttgggtcttc agataccaca 182821 gtgggcaggc ccagaccata gctcaggcag ccacgaggca aagccagcct cgctgctgag 182881 cggatgtccc tggctgattc ccttactcac ccaggtgtgg cccctgtgag cctcacagca 182941 ggcctgggtg aggacctggc cttcacctcc cagctgactc tgcacgaggg cctgaattca 183001 ctcactcacc caggtgaggc ccctgtgagc ctcacagcag gcctgggtga ggacctggcc 183061 ttcacctccc agctgactct gcaggagggc ctgcattcac tcaggcatga ctcgctaagc 183121 actggagaca tgggggacag ggaagccacg gcgagccatt gggcaggaga agcctgccac 183181 acctgaatga gcacatggcc gcgcacattt accagtgcca gaaacatacc cagccacaca 183241 atggagtgca gctctcccag ggagagctgg ccttggtggg ctccggctga gaccagtgct 183301 gactatgccg gccttcatga ggggctggga gccggctcca ctctgcccct ccctaaagga 183361 ttccaggaga gacgccagcc cacacagaga acctgcatat gtaactccta gagcctcggt 183421 ttcctacctg tgaaatgggg ccacggtggc tggctcacag gaaaaccgca gggactgggt 183481 tcaaagcccc aagcagaggt agatggtgtg gatgctgctc ccccgacccc ctcctgaggc 183541 tggccgccgc ctccagaggg actgcgctgc actgctggat ccctcaggca tctctgtagg 183601 ggccctcagc tcacgtaagg cagcagggga gggagtcatt gccccaccct cccaggggca 183661 cctgagggga acgctggagt tctgcctcct gcagcccttt ctcccggagt ctcattccag 183721 accagcagag caggcgactc aggccggagc tggagggccc tgaccaggtc acgggggcct 183781 tgaatgccag gccagtgggt ttggatgttt ttaagagcag taagaaccac tgagaggtct 183841 taagtgaagg cgtgacatga gttgctgcat ggtttctaaa aatccctctg gctgcagagt 183901 ggagaagggt tgtcggggag agaccatggg gcagtggggg gtacaagagc agaaagcagg 183961 ggttggcacc aggcgtggag ggaagccggg ccctgagaga gctctagaat tggagctggc 184021 taggggaggg cgatcctgga agggtggggt ctggaggaga gtggggagag ccacgtgact 184081 tgagtatggg gtcatccagg gaagggggtt ccagaggcag ccgagcaggc aagcctggag 184141 cccaggagga cttctaagcc caacatgggg tctggagtcc aggagaaggg tggccacaac 184201 cgtgttcacc accctgcaca attctcctcc cttcttgtat gataggcccc tcttcattcc 184261 agagtttggg agtctgtccc tccccctcag tcccaaaggt gggcaggaga cctgggctag 184321 gcccgcacca cagccatggg tttgaagatg ggcctccaat ccctccccca actctcacag 184381 gtgtcaccca gagaggaggg ctttccatct caaaggttgc ctccttggaa aacgagttgg 184441 gcctggagcc gctggtgggc cgggggttga ggggtggaga gcaattctga aatgaacact 184501 gagaggcagg gctgagaaat ggatagcatg ctctgagccc ctggattcag ccaggcctga 184561 agccaacact cctcaggacc cccagataat tggggccatg ctgtcccttg tttgtttcat 184621 ccaatatgag caggggtttc tgtcacttaa actgagcaag tcttaaggtg acaagtatgg 184681 cggaggctga gactggcctt agcagctgtg taggctgctt gcagctgggg cccacaggag 184741 cctctgctcc tacctgggga gccccgacac cctagggaac ccagaggttc ctgcagcccc 184801 tctttagtct tcctgacaac ctctcattgc gatccaggca gtgccaaggt ggggtgggag 184861 gaaggaagac cctaccagcg gcagctgcaa atctcaggtg cccctcaccc cactgcacag 184921 tcccaggacc cgctcacacc tgcctgatct gctctagcac ctgagcctgc tggagcccag 184981 tgtgtggcct cgaaggcagc agccttgctg ggaaaaatga aactcatctc gatcccttag 185041 gccggcttct gacttctctc tgtggccttt atgactctta atgtccagca agacagagtg 185101 ggtgcctggc ccagacagca gccccgcagg ggagccccag cctgaaaggc agcagccctg 1851S 1 gatttcttct tgccatgcaa ccttgggtct ctctgagcct cagccacgca gtggggcagc 185221 cctatctcac agggttgtgg ggttcgcatc aagcatccag ggaagggcat acacttcctc 185281 ctttgggccc caggattgga ccaggccttg gagggcggac catctccacc gcccagccca 185341 tggaggcttc atccactgct gcccagcctg gcaggagagg atccccgtgc tgccctgagt 185401 ggggaggcag aggcgggcag ggttgcttcc atcccacgga agtcccagct gcagtccccc 185461 accagtgagg acttaggcca cccataggag ctgcagccca gcgcaggtca cgagccagtc 185521 aaggccactc agctcccagg cctgctcccg gctccactca cactgacgat ggtcaaaccc 185581 acaatgagaa cgtctccagg agtcaaataa gaaaggtggg aaatgttgta aagaaatgca 185641 tttttaaaat tctttttgta ggcatgcagg aaaaggcaac aaaacatagt gagcatggcc 185701 ttggaatcag atttgtgttc aaatactggc ttcgaagctt gaagcaagct atctcgactt 1857S1 ttggagcctc agtttattca tctgtagaag ggggatgatg tcgggatatg ttccgtaggg 185821 tgctgtgagg attaaacaag gcgaggtggc acagggggct cagctgagag cctggcacac 185881 aatgttaata ggaacacagt caactgtcac ttaccatcat taccttttac gccaaaaggc 185941 ttctcactgg gtttttaatg ggcatgtaaa aaccacgtga aattagcacg cctaccacgc 186001 tgcccaggag atactggaaa actcttccac agcaacgtga ggcacaacac cactctgtgc 186061 agcctgtttt gctcatgcct tgtgcaaagg gacattttgc tgtggatact atgaataacc 186121 cctcgctgtg gatattatta tgaataactt ccgtctagtc actcaacctc ccagagcctg 186181 agtgctccac ctgtaaccag ggatgagatg cctccccgac cagggctctg tgaggacaag 186241 aggtgccctg tgtaaagacc caggtcctta gcaaagaagc ctatcgtggt ggcagcagag 186301 ggggatttaa cagtaggaca gacacatacg cagcaacaaa gtcagaaaag gaaagaagag
186361 gccgggcgcg gtggctgagg cctgtaatcc cagcacttta ggaggccaag atgggcagat
186421 cgcttgaggt tgggagtttg agaccagcct gatcaaaagg aaagaaagaa agaaaaaaag
186481 gaaggaagga aggaaggaaa gagaagagaa gagaaagagg acaagcgaaa agaaaagagg
186541 ctgggcgcag tggctcatgc ctgtaatccc agcactttag gaggccgagg caggcagatc
186601 acaaggtcag gagattgaga ccatcctggc taacacggtg aaacaccgtc tctactaaaa
186661 attttaaaaa aaataaaaaa aaattagctg cacgtggtgg cgggcgcctg tagtccctgc
186721 tacttgggag gctgaggcag gagaatggcg tgaacccgga aggcagagcg cttgcagtga
186781 gctgagatcg cgccactgca ctccagcctg ggtaatagag tgagactccg tctcaaaaaa
186841 aaaaaaaaaa aagaaagaaa acagaaccaa tggtgctgtc ccactgtcca aggccattat
186901 tcagtgacag cattcaatgc cgctcaggca ggtcccagct cctcttccaa ccccaatatt
186961 cttcccagct ctgtctggta catgggacac ttcagcaggc ctgtcctgcc caggccaatc
187021 cacacctggt acctctgcac acgctcctcc ctctgcccgg gttgccaacc tgcgtctttt
187081 ccagctggcc actcattctt ccagccccca ttcaaacagc cccccaggag cacactctcc
187141 aagtcctggc cagagtgtcc gtcagccacc ctgacgacag gagccctggg tgggtaccag
187201 acctgcctca ttgctgacca gtacagggga taaacatatg agaaggtgct ggctgaaaaa
187261 tgaatcacca aatgaactgc tgaatgaatg aaacagtgac aagtcctccc caaaatgctc
187321 tccatcagga atgcatagta cacaggtgtt ggcccaccaa cagactgcaa ccccatgtca
187381 actcccacca ccttacctca ccctaagtcc gcagcaaaca tctcctttca tttaggaaat
187441 taacctccag cgtaaaatgg gacacacctc tgaggcccag gatgtcctca gagacagtgg
187501 gcgatgtcaa gggctcacca ttttaaccca gctcctccag ggatatttac agttgtttgc
187561 aatatggcca agttctaact aaatccagcc aaaggcagtg attttccaaa gcaacaagtg
187621 atattttctg tgtctccata gaaagaatga cagtggttgc agagccctgg tgtaattgcc
187681 ggctctgcag actgtaggat gagcctcagc tgcccgagta cgggcgtgct caggggccac
187741 gggggctggg agagtggcca ctcactcggg gcaggagttc cctgagtagc aattagagcg
187801 gaacccatgg tgggcggctt cagatgtctg gccagcacag ccagcctgac caccacacac
187861 ccaatccaaa atagaaaact gcagtggcct ctgctgtgtg ccaggccccg ggcagccgga
187921 cagagcaccg ccaatgtcag cctcctccct cagcatcgat ccaggcttcc tctgaggccc
187981 ccttgtgctg agccacggtc cctcctgccc tctccaggaa gcagagcttc ccagagctcc
188041 agtcacagga ctagagaggc gcaggcagtc tcaaaaggga tcccctagcc tctctcttgt
188101 cctt σaggcg ctgcccccaa aagatcgagc agctcatggg cactagagcc ttcatttcca
188161 aatgcacccc tcagctcaaa atagagaaaa ccaacttttc aaagaaccag ctggagttca
188221 acaggaaacc acagcagaaa aaccaatgat tcccggtcag ccaaggggca gagggctaac
188281 tgggcatttc agcatcactg ccagctccct gggctggtat tacccgcacg caaggaaaca
188341 ggaagactga ctgccagccc ataagtccac cacacacata tcacgccagt atgcacaagg
188401 acggacacaa actcaacaga tgctcaacac actgatgtgc agaaacccag acacatacgt
188461 gcacaagaga cactggcaca cgcacatgtt cacacaggtg cacgggcacc cagatgcagg
188521 tac caccaa cgttccacaa cacatgtgca cacactcaca aagg acaca cacatacacg
188581 gacccacccc cggatgcaag ccagagacct gttcaggcag gcaaaagaga gaggcgcacg
188641 ctcc tgcctg ctgagccttt tggagacccg ggcgctcccc atgcataaat ggccccctgc
188701 tcagaccagt caaaacaacc tgctttccag ccaagccctt cagttggagc acgaggctca
188761 ctaaagcacg ggaagggcgc ggaaagtcct cagcgcaggc cttgccctcc caagggactc
188821 ccaggtaacc cttttccaaa acccaggcga gagcagcgga gagaaaggag ctagagaagt
188881 gcgtactcac cagcccatcg cagttgctga gcgccacaga ggaggcttcg gctaggccgg
188941 ccacgtctcc gacgtagaga cagctcccga gcaggggctc cacgcgggtg gtgcccttct
189001 cgccctgcca ctccatagtg gccccgggcg ccacgaggcg ggcgt tgggc cgcagccgca
189061 ggtgcaggtc tcggccaaag accgtgacat tgtagaagag gtgRctgcca ggctcctcct
189121 cgttgcctcc gggRaagctc ggggtccgga ccggggcggc cctgcgggct cgtacccctg
189181 ctc ggacgt agctgccgac accaYgtggg acaccaagcg gccctgggcg tcagtgcgca
189241 cgggcaccgc caggatgcgc tccgctccgt gccccagggg cccgcctgca acgggaaggg
189301 gcgt tagatc ggcggagacc acggagcccc agtgcctcag agacccgccg gcaagccacg
189361 cccccccaga ccccgcccca ctgcgaaggg aaggggcatt ccgccaggcg accccagaag
189421 ccagcctgca cctccccggc tttcctgcaa
BVES genomic ;sequence (SEO IDNO: 7)
>6: 105556851-105654950
1 agggcggatc acttgaggtc aggagttcaa gaccagcctg gccaacatgg taaaaaccca
61 tctctactaa aaatacaaaa attagctggg catggtggcg catgcctgta gtcccagcta
121 ctcgagaggc tgaggcacaa gaattgcttg aacctgggag gctgaagttg cagtgagccg
181 agattgcgcc actgcactcc agcctgggcg acagagcaag actccatctc sggggggggg
241 Rggaaaaaaa ggtaaagtaa aggataataa aacagcgatg atttctctat tttatcatca
301 cttgctgggc acagtggcac atgtctactt gaaagaatca tttgaggcca ggtgtttgag 361 gctgcactgt gctacagtca tgcctatgaa taacccctgc agtccagcct gggcaacata
421 gtgagactca gtcttaaaat tttttttttt cagaattcta tttttcaata cgtcttatta
481 aatataatag ttataataat tattatatta taattatttt atcttttagt gtagttggaa
541 ataggtccca atactatgaa agatcaaaat gtttcaagat ataggaaaaa caaaagcact
601 gagaagaaac aaaaaaacta aaattgggtc caataattca gtgttaaagc tagttggtga
661 aatagaagac tctgtgccta aaagtgctta taaatgtttc ttgcatctta tgtagtggct
721 ctgtggtgca tatttactgt atgttaaagg ataattttca aaaaaggcag cattatgatt
781 tttatgcaaa tatcagatga Rtaagtgtta aagaatttat tgaacacagt taagtgagag
841 aaccaaatgt tgtaacttgt tcaaaggaga atcaaagaat agacatattt gtagat caRg
901 tatattgaca tgaatatgca aatgaagcca aaactggctt tttccacagt ggggaaggga
961 aatcagttga ctctccactc tccaggatag aatttgcccc tctgtaaaga aaaatgatgt
1021 tgtatttcta tcagttatca gtcatggaaa gagctataaa ataaccctct tagaatcaga
1081 atcagataat ccagaagctg ggttccagat gttttccact gaagcacagc tttcccccgc
1141 acatatattg cattcattca aattacatgt caaacacata aagagaactt tacattcaga
1201 gtggtaaata gcactgccat ttgtagctat tgtattttta aatgtttatt ttctgaaata
1261 aatatatttt ttgaataaaa ggctcaagta ttgcccaaac aaatttacct ccttttacca
1321 caccagtcag ggtatcattc aatatttttt aaagaaaaat ctagaaaaaa atatttagtg
1381 tctttgtttc tcttgttcca ctaagagaat aagccaagtt cttcatggaa agttcctcca
1441 gccaaatcta gagggtgacc aaaggagatg aaaactcatc attcaaatac ttaaggaact
1501 gtactcataa taaagcgatt tttttggctt acagaatatg tgcaaataaa tctgttaaca
1561 tgtagaatct agccctaatg attagaagtt attaagagta tttggacttg tataaacaat
1621 ctggttctat ctggggattc tccagggatt caacggctct tcccatactt accttcagat
1681 tttacctcca ccagtggctg tgtattcaca gggtcacagc ctcgaaatgt tcaaatagga
1741 agacaagatc ccttaaggga tcagtgatca gagaaaagat ctgtagggat gtcttagcag
1801 cttgaccatc aggctttagt cataaaaaga ttatgacatg aagggcaccc tcagtcagca
1861 aggaggagga aaggaagtag ccatgaggcc aagaacacca tacaagactt tatcttgagc
1921 tctaattttt aaggtaagac ctacacaaga gaagataata tcacagttta cagaggttat
1981 ctgaacatgg tagcaatttt ccttgttcag tttttactta cgtacatggt gaacagttga
2041 agaactgctg attcttggca aaaggcaata tatagtctgt cactggaaga Scagttgggc
2101 cagagggaga aatggacaga ggtcatttac ttctcattta tacttcatcg ttttcctcag
2161 cggtagctgg tgctggaatg ggagaccaaa cttatcgatc attagaagcc tttcctttct
2221 gacttgagca aaatggtttt aattccttct cattgctgtg tagctgtcaa gacaggtgat
2281 ggcttgggaY agtcttcttt tggctcttgc acatgaattt gtactgagaa cacattttgg
2341 ttaaatcata ccaggcactg tgttctaaga ccactggccc tctataaatg cttttaatgc
2401 tattcatata aacattgtca aaatggaaag atgattaatR tttcttacta attcaataat
2461 gtaataataa tgcagggggc tgggggtatt ctggctcaca cctgtaatcc cagcactttg
2521 ggaggccaag gtaggtggat cacttgagcc gagcctagaa gttcgagacc agcctaggca
2581 acatagtgag acctcgtctc cactaaaaat acaaaaatta gccaaggcat ggcggcacac
2641 acctgtagtc ccaggtactt gggaggctga ggcaagagga ttgcttgagc ccaggagctc
2701 taggctgtag tgagc tgtga tggtgccatt gcactccagt ctgggtgaca cagcaagact
2761 ctgtctcaaa aaataataat tagttagtaa gtaggaagtg ctagtagtta gtagtaagtg
2821 ctagtaattc agtagtcagt cagccataca ccaatagaga ggtgttttaa cattctgtct
2881 tcgtaaaaac tcagattcta ccagcattat tagttgcatc aaaggtaacc cagtcatagg
2941 taacttcaaa gctttgaata acccagaaga tatttacttt gctaaaacta gggtaacatc
3001 ttttaatcta gcgccctttt gcccctggct tgcaaacaac cagtataaat ttgaagctgt
3061 tatctaatct tgtatgtaca gtacatcagt catgccacca aaattgattc ttgacttcta
3121 tacgtctttc tttcctttgg aatttctcat gttctctctt ccttctgtgt tttaatgaag
3181 aagtgtatgt gataaaatgt gagctagtca ctattttata gtccttattt tgtataccta
3241 aggtattttt aatatggtgt taaaattctt ttatatattg tttggacatt tacatctact
3301 tctctagata acaaattatt gcctcactta tcaggtaatc atgatggaat tcttctttta
3361 aaatttcttg tgctc tggtc aaatgtccta atagtaagac attttacata tatatatata
3421 tgtaaaatat gactt tagaa tgacttacaa aataatgtta tattaataga taaaaagaat
3481 gctggctgca gaacaaaagc ctaaaagaaa tcatgcgatg agaagaaaaa aatatttata
3541 agagttgaca caaagctcta gtggaattgt atttcttcag gctgagctga tgcttattta
3601 cagcagatgt cacacctctg acactgtgaa tttgaaatag tctggtgaaa aaagcaagca
3661 gccctgatgg ttttaagttt tcggcaaggc tgctctaata aatgaacaaa catttccaga
3721 ctgcatatta taatc tgatt cttccatcta agcaagcacc taattttaac catttcaaga
3781 taagttaaat attgaacgtc ttcccttcct ttcataattg atagtagtac taacttttta
3841 aaacacttta actcaaaggt cagtaagacc aaatagagtc aataaactga tcttgcttcc
3901 aacaaggatg aatgt aaacc tgcagttagg atagttaaaa cactacaaca gcaaaaatgc
3961 atgtggcttt tatttatttg tgtatatgtg tgtgtgttac tcctgaactg gacactcctt
4021 cttagttgtc ttgggttctg aaagcagcac tggccgagta cccactgcat gtgagactgg
4081 gtcctatttc ataacaaact gcttttactc ccaggaaatt ggaaatcatg aagttatctg
4141 tgtttgagta atctt tctct ctctctcttt tttttaaact tttccattag ccagaacaga
4201 ctatctgtct gagatgttgt ttatcatgta agagagagat aacatttcta tttgaaataa 4261 agtttaaact tatgacctag aattcattat tatgctcctt ctcaagttac agtacaaagt
4321 agaaaacttt catcaaatga atattgttcc attgatttga cacagaatct accaagtact
4381 tttaaacata atggaatgat a taaaaat gtctggttta tagctatgcc tgattgaagt
4441 acccttatat gaaaaatgct cccctttgcc cccatgcctc cagtgatttc tctccccttc
4501 catgtcttgt ttgcttttaa aactgctaca tgtttcatcc ccatttctca gtgatctgca
4561 ccaccattca ttacataccc at tccccgca tttttcctct taccttcttg tttttataag
4621 atgatgaaag gtttgtgaat agagctatta ctgtatttta gctggttttc agtatacttt
4681 ggtgcatttt cactgatgtt atgagatagt tgatggcatt aatcagagaa agtgtccaaa
4741 agctaataaa cctatgacaa tσcaaaaacc agtcaggaga agatattaaa tgagataaaa
4801 tgtgtaaatc ttaaccatcc agctaactat tcacatacct ttcattggca tctaatacaa
4861 agttgtgcac atagtagata tt cttcaatt tttttgtcca tttggttttc atttgattct
4921 atgaaaatga ttaaatgaat at tataagca gttgaatcMa ctagcagaca atgtgtctag
4981 ttaatttctc atcatataat cagatgataa aagaggttag aacagtagtt gataattttt
5041 tttaaaaatt agttaagttg gt ctgaacac tgagctttag gggagacata gagtattcat
5101 ttccactgcc agcagttcag agtttgaatt tactttggtt ccatgagacc acaggctgat
5161 ccctgcttgt tacgctgaat agtactggac aatacagagc cttccaaaca cacgatttat
5221 tatgcaacag aaagaaccaa atggcaatta tactaactga attttgcttt ttatttgata
5281 atactgagca cctacccata gggtggtctg attaaatagg tttaaatact atcttttatg
5341 gacttccttt tctttaggta tggaaaacag tgagcagtag ttatcttatt aatggcatta
5401 ttttaagcac aatgtagttt agatattagg gttttgaaaa ataacatact taatcatttt
5461 tataaaaagc agagatctta ttatatttat actgacaaga aagtaatttt ctatttaaat
5521 gccaacagag gccgcatgca gtggctcaca cctgtaatcc cagcactttg ggaggccgag
5581 gcaggcagat cacttgaggc caggagtttg agaccagcct ggccaacata gtgaaaccct
5641 gactctacta aaaatacaaa aaattagctg ggtgtggtgg tgcacaccta taatcccagc
5701 tacacaggaa gctgaggcat gagaatcatt tgaacctggg aggtggaggt tgcagtgagc
5761 caagattgtg ccactgcact ccagcctggg caacacagtg agaccctgtc tcaaaaagca
5821 aaacaaaaca aacaaaaaaa cagaatttgg ccatggagag aaacgtttgc aagagcatgt
5881 ccatactaaa caaatttata tgctgttcaa aattatttta gatgtaggca atagaagatg
5941 gagaattaaa agagttatta tgggaaatca gtaattgtta attggtaatg atggtgaaat
6001 ttagggaaag tagctattga ttaaggagct gtaaatttgc tgggtgcagt ggctcacgcc
6061 tctaatccca gcactttgga gaaccaaggt gggaggatta cttgagccca ggagttcaag
6121 accagactgg gtaacaaagt gacagcccgt ctctacaaaa aatttaaaaa aaaaaattag
6181 ccaagcatgt tggcacacac ctgtagtccc agctactgag ggatgctgag ccctgattat
6241 gccactgtag tccagcctgg a aacagagc aagaccctgt ctcaaaaaaa aaaaaaagct
6301 gtaagttatc atccattttg atgacacaag tatacattga acctgttctt gattgataaa
6361 ttataaattg aacagagaaa ccatatctga agttaaactc agtaggtttt tgcagtgtgt
6421 gccttccagg gatcagtgat ggtaaaaggt tgaggagctt ttctgccatc acaaccagaa
6481 atttcaagga tccattctca a aaggaaat aagagatata tacacacact tcttccctcc
6541 cttgcttact cccttatttc cttctctttc ccttcctcct tccctccttc cacccctccc
6601 ctcttccttt ctgaggcatg agtgagtaac ctgttgaaaa ctgttttgag agatttattc
6661 tcttttgaac cacattcctt a agtgggaa atattgtcag tgcgacactt gagtttgtta
6721 atagctgtag ttctcaagta gctgcacatc accatctcct gggaaacttt aaaaagtact
6781 gatgcttagg gcatcatcct caaagattct ggtttaattg gtctagagta ggaccaaggc
6841 attagtattt tttgaaagct ttcaaaatga ttctgagtca ctggtagaca ggctcactgt
6901 cagatgacta acaataataa tgaaggtcaa ttacacaatg gcaatggggt tttataatta
6961 taattgctct tttttaatta cacaaataat atatcagttc tttcttgtta tttaaaaaag
7021 aaactataca aaaatttaca gagtaaaagt gaaatgccag ccaggcaagg tggctaatgc
7081 ctgtaatcct agcacattgg gaggccaaga tgggagggac tgcttgagcc caggagttag
7141 acaccagctt gggcaacatg gcaaaactct atctctatca ataaaaccac acacacacac
7201 acacacacac acacacacac acacacacac acacactggt ggtgtatacc tgtagtctca
7261 gctgctagag agtctgaggt agaggatgat tgggtttggg aggtccgggc tgcagtgagc
7321 ccttatcacg ccactgcact ccagcctggg caacagagct agaccttatc tcaagaaaaa
7381 taaaatgccc tttcaccgta ctattttccc tggatgtaac cactctttat ttgtcaattc
7441 actgtcttcc ctcccagtgg tttttacatt cattcattca ttcattcatt tgacggagtc
7501 ttgctctgtc acccaggctg gaatgcagtg gtgcaatctc agctcactgc aacctctgcc
7561 tcctgggttc aagcaattct cctgcctcag cctcctgagt agctaaaatt ataggcacgc
7621 actaccatgc ctggctaagt tttgtgtttt tagtagagac ggagtttcac tgtgttggcc
7681 tggctggtct caaactcctc ctgaccttgt gatccggcca cctagacctt ccaaagtgct
7741 gagattacag gcatgagcca ctgcacccgg ccggttttta catgcatttg aaaatgcaca
7801 caattactta taatcatgtc taatgtcttt gaaacataaa ttcgatcata ccgtatttat
7861 gtattatgcc gtggtttgct ttttttactt aacaatttgt cttggagatc tttScatgtc
7921 aatacatata aatttacctc aatttttaaa aaattatttc attattctRc tRtctgcaaa
7981 atgttttttg gtatatgtgg ctttaattta tttttcattt taacaagttt atagcttaac
8041 aataacaatt agttattgtt agcattatta ttataattta atttttctaa ctttttacca
8101 gtatggacaa tgctgttgtt aatatcttag tacctgaatc attgtgttta tcagtgaata 8161 ttcctgtaga gcaaattcct agagtgagag ttactaggtc agagagtatg tgtattaata
8221 ttttccaata tgctgtcaaa ttgtcctcca agagaggcag tctcaattta cattcactcc
8281 aaccaatata atctgattgc aatatttcag agcctaaata aatcattcat actgcagtgt
8341 gatttaatgg gctaactaaa atttccatct tctctctttt gactggaatt ttattgagtg
8401 agtttgatag cactgattat atagcatatc agcttaaaat tccaatttat aatcttaaac
8461 atatgattaa agagaataga aaaagtattc acaaattttt agaccaagtt tttcaacatg
8521 taaagtatag gagagatgaa aagaaaattc agccttggca gtgtaaagaa tctggattgg
8581 actactccca gtcttttgtt ttatagatgg gatgctcaaa gaaacacgct gacctcccca
8641 gtaacaaagt ctcaggaaaa gtctacttca attcttttgt gtctgtgtgt gtgtgtgtgt
8701 gtgtattagt gttttaaatt caagatccta g-atattttag acttacatat aataaaatta
8761 catcaatatt gttgggtata acatttttat gtaatcaaaa tggaagtgaa atttaattgc
8821 tttcaattaa aattcctttc tagataatct ctaaatttct tcatcaatac aatttagata
8881 ttgtagttcc caattcatag gctttggggg tggattaaat tatataacac attaaaaacc
8941 tttagcacag tgtctagaat ttagtaagct ctcagtgaat tgaacctgtt tattatttct
9001 gttattacca ttttaattct cttaaaagta aaagtatgtt tagtccttct gtatatagaa
9061 tattttgttt ttagcatgat taaggtaaca gaggggcatg atgctggctt ctatattcca
9121 gaagatccaa atgaaaactt ttctggtgtt aaatgtgtat ttattatcta ggaaactttt
9181 taaaagaaca taaatcatca gtatcaccaa ctaactattt ttgaaaactc agtgttttta
9241 ccactgtact tagaatatat aaaaatttaa gtatggaaaa catacttaaa taaaaattaa
9301 ctttactaaa attgttattg tttaactggc ttacaatctt atgaatttgg ttatgagaag
9361 aatgaaataa aagaaactaa ttcattaaag tataggttga tagaggtcag aagacatgta
9421 cactattaaa gagacttact agttctgtga ctcatcaaag tttcctaact cctctcttgg
9481 tattttgggg ctagtcctgt ggagtgagta aacaataccc aaatgtttat ttagattgtg
9541 tagaatcagt cagaacaaaa tggggccttc tttaggaagg ttggttccag gatctgcccc
9601 tcttaccttc aggaggtgta cagggtaggc agattgcttc catcaatatg ctctggatcc
9661 tttgcttgtc agctctctgt ggttctctaa taacctttct gcccacccac ctccccacca
9721 ccagctggct gtgatccagc acttccatgt gttcagttga ttggcacaca attttaatta
9781 aataacaagt attaaaacat actagaataa aaaataatag agctgaggaa tgttattagt
9841 atcatttctg gattttagtt ggactgtacc aaggtttaaa atgatctctt caaagaatca
9901 gttatttttc cttcagttta gttcctgtaa tttttttcaa tctgtgactt ttctttagcc
9961 cctctgcctc ccatttggaa actttattaa tccttttttt agtccgtttt tcccaggaat
10021 ttttatgaaa ttccttttct gtattcgtac cttcttcctg cccaaagctt gcacttcttt
10081 ctctactctt ttctctgtcc ctgatactgc t ttacgtact atctttcaac aattccttcc
10141 ccttcagaag cttacagatc actgtcaaaa t tatccttaa tgcccccatc agaccctcag
10201 aatgtggatt tgagtttaca tataaattct tattaactta aaatgttcaa gtactgtgaa
10261 gaatcctaag atacattttt ttccattata cttttagaca agcaaatctg gatcttcctc
10321 tgtggtatcg cccctcttcc caattttttt catcactctc aggatcgaga gggaatatat
10381 aactgatgaa tattttcatt tacaccattg gaatattatt taaaaattaa tgtctatatt
10441 ttaacctagt ggttgtccgc tgtgctcagc tccattattg ctgatatcat ttgaaaatat
10501 aatctgctta ttcagttgtt tggatcaaaa aatgcaaaca tttttaatgg tcatagcaga
10561 tctaaattct gatttctgaa ttagttttca ttttttgatg aaatcctcag aaatttgggt
10621 atgttttgat taacttatta actagtgtag gtgtttggac ttgattttta aaaactcatg
10681 taattacttc agaatataat taaatagttc fcaaaggtcta aacaatttgt ttttatttat
10741 ttaaccatca taagtgcctc tattctatcc attgttgcca ttctttcatt taaaatcttt
10801 tctttttttt gagacagagt ctcgctctgt Y"gcccaggct ggagtgcagt ggtgcaatct
10861 cagctcactg caaactccgc ctcctgggtt cacgccattc tcctgcctca gcctcccaag
10921 tagctgggac tacaggcccc cgccaccatg cccggctaat tttttgttat ttttagcaga
10981 gacagggttt caccatgtta gccaagatgg tctcgatctσ ctgacctcgt gatctgccca
11041 cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgcgtcagg ccttaaaatc
11101 tgaaattata aatcttattt tgatagtgtc tcaaaaatgt tgactttgat ttgattgtta
11161 attatcttct atctttaaac gctccttaaa taagaaataa tacttgtaga atatgctagc
11221 tcattagaat tacagtattt ataaaatgat tttatgaaga acttgataac cgtctaagat
11281 taaactgaac atttttgttt attttatctt tgtttgttaa aacagagtct agccctgttg
11341 cccaggctgg aatgcagtga atcaatcttg gctcactgca gcctctgcct ccctggatca
11401 agcaattctc ctgccccagc ctcctgagta gctggaacta caggtgtgcc ccgccacacc
11461 tggctaattt tttgtatttt tagtagagac sgggttttgc catgttggcc aggctggtct
11521 caaactcctg acctcaagtg atctgtccgc ctcagcctcc cagaagtgct gggattacag
11581 gcatgagcca ctgcacttgg cctattttat cttatttgta atgcatgaga aaatatcctt
11641 tgtgccattg gttcagcatt taataaagta cttagcatga ataattttat tttttatgtt
11701 ggactatggg aatatataat aaagtatgag tatagttttc tttgtatggt cttttgtgtg
11761 agactatgtc cttatatttc ttaagcatat εagctaaaaat ggacacacat gatattttta
11821 tgctcacatc acaatgtaaa attcattcca εactacaaagg caaactgatg tggaacagtg
11881 tggagggtga acaaagggga ctaaaatcat gtatagcttg tatggagtat atagttgtgg
11941 tataatttgt gagctgcaag gtagctgaac εatttctattt tggtgtcagt cccttgggaa
12001 ggaaggggtt tcataatgga gagtgatctg tactcttagt aagagtgatt gacactgaat 12061 gattaaatag aagagaatat aaataccact cctccccctt ttaaggctaa gcacatagac
12121 actaaatgca aatcttttca atgtggaaga aagtctggcc taatgatagc acatatcagg
12181 aaagccaagg gggtgaatta actatgcaga tcaaaatgta aggaaaccaa aattatatag
12241 catccttaaa aataactttt atagcccaaa tctaatggta aatgcacaga tagagggtaa
12301 ttgaagatcc catttgtgaa agtagaatac tgacatcagg ctcctggtca atgagtgggc
12361 aaaatggttc cctgaattgg ataacacagt gcataccaYg gtgactgata aaattgatgt
12421 gtctgcagga gagccagccc tattactgaa gcctttaacc tattttctgt ctctttgaaa
12481 atgagctcct gagtggaagt tatcctcaag gaagtgaatt taattcaaaa gaagatattt
12541 tatagatggg caactttaat ttaagaattc acttatctat tgtagaggag aactgtgtgg
12601 gaaaatatat tattataagt aatgtggtta tatttttcaa atatgtcatt ttttagtgtt
12661 attttgagaa cctgaatttt aagcattagc aagtaaactt tattatttaa tcttacactc
12721 tcttagaaca tatggctgaa acaatattga atctgcactg taatacttta ttaagatatg
12781 taattataca atgaataatt taactacaac atgtgatttc ttgttttttt ttctcttttt
12841 gaaaatatga ttcagtctgt cctaagataa atacttgtta atcattgcaa agaataaaag
12901 cccatcttat aaattcatta ttctaaagta tataaggtaa tattgctaac tggagaagca
12961 ggcaatagtt accctaattt ttgccaatta aaaaattcac tgttcaattt atgccaggag
13021 ataaaatact aaatatccta tatacactgc ttagtaggtt gttagtacct tagtagtttg
13081 tctatgaaat ataaggtaga ataaattatt aagtttgatg ttctcacaca catacaaata
13141 tgtcatcata attcacttct tgttgtgagt ctggacttaa gccaattttc tcagttaaca
13201 ctttttttgt tgttgttgtt ggagatggag tctcactctg tcgccaggct ggagtgcagt
13261 ggcgcaatct cggcttactg caacctccgc ctcccaggtt caagcagttc tgcctcagcc
13321 tcccgagtag cttgggacta caagcgcgcg ccatcatgcc cagctaattt ttgtattttt
13381 agtagaggca gagtttcacc atgttggcca gaatggtctg gatctcctga cctcataatc
13441 cgcctgtctc ggtctcccaa agtgctggga ttacaagcgt gagccaccgc cacccagcta
13501 gttaaaacat tttgttatta ttttttaaaa acattataac ctggctgggt gcagtggctc
13561 acgtctgtaa tcccagcact ttgggaggaa ggggcaggcg gatcacttga ggtcaggagt
13621 tcaagaccag cctggccaac atggtgaaac cctgtctcta ccaaaaatac aaaaattagc
13681 cgggcatggt ggcacatgcc tgtaatccta gctactcccg aggctgaggc aggagaatcg
13741 cccaaatccg ggaggcagag gttgcagtga accgagatca ctgcactctg gcctgggcaa
13801 cagagagaga ttccatctca aaaaatatat atatataacc Ygttgttctt tgtgcttcat
13861 aaatgagatt tatggagtca taaatgtatt tggaaaataa aatagaaagc tcttaaaata
13921 tttcatttgg agacaagtca ttaaacaaat tctgtattta aaatcagatt taacaccttt
13981 ggtaaatata aatttttctt agtttcttcc actaatggtt tttttgttac ttttaatata
14041 aaattttaga agaaaatctg attgaacaaa tatacctctg aaaaaatttt cttgcttagc
14101 tttccttgcc aagctaaaag ctgaactttc aaacatctaa tacaaagcca tgtccccagt
14161 gtgcattcac atattatgga cggatttcca tttattttaa cttaaaagag atcaccctaa
14221 aagaaagcta atttcttaca aaaaagaaaa gaaagttaac ttttctcatc attgaactag
14281 catgaacctt tattaattca atctaagtat ttagaagctt tcttttttta gcactgttct
14341 gattcagaca tttactctat tgctctaaaa ttacttggta atttgccaga tatcatcctg
14401 actttctgac tagactctga ctt tcttata tatcaaattt cactgcatta cttaatttta
14461 Yacaaaggaa aaaaattttt ccagtttagc tggtttctac agtcaaaata attaacattc
14521 aaagaagtgt taaactttta aat ttggtct aaaattttgc cagtttctga gtgaattgcc
14581 actttgtatc atgccaacag ctgtatttct acactcttgt ttttaaaact ggcttgttgt
14641 tttttgttga atattcgctg ccc tctagtg ggcttaatgR ttcttttaaa atgaccagat
14701 agtgtcaaat ttaaaggaat cct ttctata tggaagtgat taaatattct tacatgtttt
14761 aatactcttg tttttcactg tgtttagttg tgtctcacac aactaagttt ttaacctcac
14821 cagaacattt tggtgatgat agt ctttgaa ccaacagtgt aaccagtata aacaatgata
14881 aatgctttta agaaggcaca ttaaaataag cttatctcat tggtagtttg tgtgttttca
14941 cattttaaaa tgtgtttttg gatacatgct gcctacttct aagatgtttt catctttttt
15001 ccttgtagat gctacaactg tggtggcctt gatcatcatg ctaaggaatg tagtctacct
15061 cctcagccaa agaagtgcca ttactgtcag agcatcatgc acatggtggc aaactgccca
15121 cataaaaatg ttgcacagcc acccgcgagt tctcagggaa gacaggaagc agaatcccag
15181 ccatgcactt caactctccc tcgagaagtg ggaggcgggc atggctgtac atcaccaccg
15241 tttcctcagg aggctagggc agagatctca gaacggtcag gcaggtcacc tcaagaagct
15301 tcctccacga agtcatctat agcaccagaa gagcaaagca aaaaggggcc ttcagttcaa
15361 aaaaggaaaa agacataaca ggt cttcttc atatgttctt tcctttaccc ggttgcaaag
15421 tctacctcat gcaagtatag gggaacagta tttcacaagc agtagctgac ctgggatttt
15481 aactactatt ggggaactgt gaatttttta aacagacaaa tcactctaag caaattacat
15541 ttgagcaggg tgtcatgttt tatgttaatt cagagaataa gatactatgt ctgtcaatat
15601 gtgcatgtgt gagagggaga gagcctgagt ctgtgtgtgt acatgaggat ttttatatag
15661 gaatgtagac acatatataa agaggctttg tctttatata tttgtgtata gatcaaagca
15721 cacaccctct ctcatataat tggatatttc caagaattga aaacccatgt gaagcattat
15781 agatagtttt aaatttaacc ca ggagtt ttcttgaaat accacttctt ttatattata
15841 taaaactaaa aacacgactg ttaccttttg tgtgaaccaa aggatacttc agatctcaga
15901 gctgccaatt atggggtact aaaggttttt aagacatcca gttctcccga atttgggatt 15961 gcctcttttt cttgaaatct ctggagtagt aatttttttc cccctttttt gaaggcagta
16021 ccttaacttc atatgcctct gactgccata agcttttttg attctgggat aacataactc
16081 cagaaaagac aatgaatgtg taatttgggc cgatatttca ctgttttaaa ttctgtgttt
16141 aattgtaaaa ttagatgcct attaagagaa atgaagggga ggatcatctt agtggcttgt
16201 tttcagtagt attttaatat cagcttcttg taaccttttc catgttgtga gggttgtaag
16261 ggattgtgtg gcaacagcag cttcccttgg ctaactcaat cttctaccca ttgcttagag
16321 cagggagccc tccttattta ctactgaaga ccttagagaa ctccaattgt ttggcatata
16381 tttttggtgg tggtttttat tcctcctgga gagttatcta atttgtttct aaaacaaaca
16441 agcagcaaag aaatgaatta aat ctgggg ttgagaatta aaattaagtg gatgttcaca
16501 gttgcccaat atatatgacc tgcaaatgat acgaaaaagt gcagcattta gtggcagtta
16561 acaagagtga caagcctggg gcagaggtac caaacctctc ccaccagaga gctagaagta
16621 ttttatacag taactttgat ct tggaag tgaccttcaa tgcttattct gaagtaacct
16681 atatggtgga tacaggatga acattcagtg ccagggagaa tcttctcagg ttggttctcg
16741 ttagagtgat aaactggcta ggggccatag tattggtcct gttaggtttc ggtcatggaa
16801 aaaaaaaWta ttttggggtc atcctggctc tagatgttat gggcaaattt ctgaaacatc
16861 tgcaagaagg taccagttaa ttatagtgct taatattggg aataagatta agcattataa
16921 ttataatgta tgggcctgtt ggtgtaagct cagataatta aataaaaata gcatgactca
16981 aatgagacat attctgctga acagtttcta cttcctctcc cgcctgtcct gtcatgggag
17041 acgtgtatag ttgctgctgt ttcagcaaac caccataaga cgaaaatgcc tcaggttggg
17101 ttgccagtcc tttacaactc agc tgaatt tcacaacagt gattgtgaga atctgcgtgg
17161 tatacactga aatatcggtg tgσtgtgatg caaagcttac ctttgacgat attgaatgtg
17221 atatagctgt agagaagtac ttccttgcct tatgtgagga tttcaaactt atttaaatta
17281 tgtagacaaa tcaaagtggc attgcttaat ttttagcagg cataataagc aagttaacag
17341 taaaatgcaa aacatgataa gcgttgctca atttttagca ggtataataa gcaggttaac
17401 agtaaaaatg caaaacatga tagataagtc actttgaaaa ttcaaaccaa agttccttca
17461 ccttatggaa ataggaaatt atggacttca aaattggaca cttcctgttt acaaaaagaa
17521 attcagagct aaaatcatgg taaaaaaaaa tagaaacact tgagaactat ggtctttatg
17581 ggtgcaattt gaaatccttt tcatcatctt accagactaa actaagagca cataccaaac
17641 ctatcttatg gttgaaagtt ggggtttatt ttttatatga gaatattatc actattacat
17701 aacatactca ggacaaagaa ctttgctcag ggaacatacc atgtaatatt tttgttgttt
17761 ctttacagac tagtctacag tcσtgcttac tcaaaacaaa ccaaataact tataccttta
17821 tataagtatt atgtactgat gatagtaact acctctgagt ttgacacaga tcaaaatttt
17881 tgaatatcag atatcagtta tcctattttt atttcatgtg aaaactcctc taaagcagat
17941 tccctcaact ctgtgcatat gtgaatatca ctgatgtgaa cacattgttc atttacatag
18001 gtaaaatatt actctgttta cagcaaaagg ctacctcata gttgatacat agcacacctg
18061 tatgtatgct gttccagcct tacaggtggc tgataattct ctggtacaga acctttttat
18121 ctgtattata aatagcaatt cacaactgca tgtttctgac aaacacttgt gaataatgaa
18181 gcatctcgtt ttagttagca aagtctccaa acatttcctt aaaataatca Ygtatttagt
18241 ttaaagaatt atgggcactg ttcaacttaa gcaaaacaga acacggaagc agtcttagaa
18301 gcaccacttt gcccagaggt ggaggttgga aggggtagca gggagagggg ttggtgtatg
18361 caggtattca tgctaggcaa agagtttaaa agaYgccaat gtccttcatt tactgtctgt
18421 gctgccctga agccaagcgt attgcagcat tatagcccca ggcacataac taactagcac
18481 tggcttgcca aggaatgaac atgcMatgcc attactagct attgagggaa aagggtctgt
18541 gtgaagcatc actttgcagg gattactaat ggtggggcag caggtctgtg aattaagtta
18601 tctcttgacc tcaccctcat gtcaacacaa atgtaattcc taaacaagat gcattgccag
18661 tctcttagcc ctgtaagctg atcWtttgct acatggcaga ctataatgaa aacattttta
18721 tacttgggtt tctagtcttc actagaaggc cttggatgta tttttgcagt tgaaagattt
18781 agaaagattt ttacctgctt ataacttgga agtttagagt gcaatgtaag aaaaaagatc
18841 aagaaatgtc atgttattag catcagtcca cctccaatat tgccgatact ttttttattc
18901 tggctcagtt ttattttgca ccagtgcggc cccaagttac tgctggttgt atttagtttg
18961 tgaataggag cccataagtg ttaatagact ttgtaacatt cactataaga tgaattatac
19021 aggacatggg aaatctcatt aagtcttaaa gttaatttaa attaatttat ctgttttctc
19081 taagaaatgt ttatcataaa atatatatgt gtatttcccc tttggttata aaatttggga
19141 aagtatgtac aagtgcagct gcactgactt taattttcta gatgtcttaa tgagatttat
19201 ttgttttaga gaagaacatc ttgttaaaag catcaaactc tgtcttacat agctgtYaac
19261 agcctcttta agatgtggtg gttgtatgat ctgtgtctta attgttcagt tagagtgaga
19321 agttgaccta tgattcattt ttaaatttta tatttggaac aaagctgcaa gttatggtaa
19381 agtactgtac tgtgagaagt attatgatat ttaatgcatc tgtggcttaa cacttgtgag
19441 agttaccagc ttgaaaatga tggtgttgac tacctcttga atcacatcta tcaaccactg
19501 gcacctacca ccaagctggc ttcaattagt atgtgttgct ttttggtatt aacaactaac
19561 cgtactagag accaaagtga accctgattt ttatatgtct ttaataatgg tgttttatct
19621 agtgttttta aattatcctg tgtagtattt agattacctc attgtccatt ttgactcatg
19681 ttgtttacaa gtgaaaataa aaacacttga actgtatgtt tttaaaagac aaaaaagggg
19741 tagatgtttg gaatgcgttt cactcgcatg cagtcatctg gagggactga agcactgttt
19801 gcctttctgt acactctggg ttttatattc tcatttcatg cctaatgtct tattctgtca 19861 attatggata tgttgaggtt taaaaaaatt acttgattaa aaataaaaca tataacgttg
19g2l gcatttatga tgggttttgg agatttttta tgatgtgtgt tcttactaag ttaagtgaaa
19981 ggataaaagg ccatttaggc agtgttttac atcagttgga gcataagtta agtggtatta
20041 acatatcctc agtggtgagt attaacatgg aacttactcc aacaatacag atgctgaata
20101 aatgtagtct aagtgaagga agaaggaaag gtgggagctg ccatcactca gaattgtcca
20161 gcagggattg tgcaagcttg tgaataaaga cacatacttc atgtagtcag aagagtggtc
20221 tgaagcaaaa tattcaaagc ctattgaaga aatcatttta gaWtttttct acaagttttt
20281 tctaataaag aatttgaaaa gggcaaattt tatcagtacc aaatatctaa aatacgaatg
20341 tagatttatc aaaccatgaa tgcagtattg atgtactgta acaaacgatt tggtaaaact
20401 attgagttct ttaaattggc cagttccaca atcaaactta ttttcctctc ttcacctgga
20461 tgatttattt ttttgatgat ctgttatgac ttttatttta ttttaaattc tggtaaaatc
20521 acataacata aaatttacta tcttaaccat ttttttttaa agatgaggtc tcattctgtt
20581 gcccaggctg gagtgcagtg gtgcaatcgt agcttactgt gggctcaaat tcctggactt
20641 gagcgatcct cccacMtcag ccacttgagt agctggacta cagatgtgca ccatgcccag
20701 ctaatttttt tttttttttt ttgtagagat ggagtcctgc tttgctgccc aggctggtct
20761 tgaactcctg gcttcaagca gtcctccctc cttagcctcc caaagggctg gcattacaag
20821 tgtaagccac catgtctagc cttaaccatt tttgattatt aagtatattc acattcttgt
20881 acaaccatgt gtgattcact tttctttgaa gggctttttg tactttacag aatatggaaa
20941 acctttaaac cttaaaagaa aaatacacat aatcccatca tctgaaagta accaataaca
21001 gcttttatta atttatattt agtatatgga attttttttt ctttttgtga gacagggtct
21061 tgctttgtca cccaagctgg agtgcagcgg ctcaaccatg gctcactgca gcctcaacct
21121 ccccaggctc aagtgattct cccagctcag cctcccaagt agctgggact ataggcctac
21181 accaccatgc ctggctacgt ttttgcattt tttgtagagg tggtaaaatc acaaaacaaa
21241 aatttactat cttgtggcct aggctggtct tgaactcctg ggctcaattg atccttctgc
21301 cttggcctcc caaagtgctg gaattacaag tatgaaccac cccgcccggc caatttttga
21361 attttttgta gagacagagt ttcactatgt tagccaggct ggtctttaac tcctggcttc
21421 aaggatccca cctcagcctc ccaaagtgtt gagaatgcag gtgcaagcta ccacacctgg
21481 ctgaaaatct taaaaaaaRa aaaaattata cataatccca tcgcctagaa ataaccatta
21541 gcattttttt attaattttc ttMtggttac acacacacac acacacacac acacacacac
21601 acacacacac aSagatacat acacatgcgg gtgatttttt tttttttttt tttgagatgt
21661 agtctcactc tgttgccagg ctggagtgca gcagtggggc aatctgctca ctgcaacctc
21721 cacctccctg gttcaggcaa ttctccagct ggaactgtag gcatgtgccg ctgcatccgg
21781 ctgattttgt atttttagta gagacggttt caccatgtta gccaggctgg tctYgaactc
21841 ctgacttcag acgatccacc tgccttggcc tcccaaagtg ctgggattac agatgtgaac
21901 caccacgcct ggccagtgtt tatacataga ataatttgat cattaaatag tccaatatgc
21961 ttatgtaatt aatgctgctt tttttttttt ttccaaataa agaatagctg taagtcacat
22021 ttaggataac aggacgaccc agccagaatc ccaggctgtc cttctctgta cacagagtac
22081 tatgtttcct acccctgtct gtgtctataa gccttttgta aggacctttg tatgaagctt
22141 ttgcttgcta ggctactaaa tcaaagcagt gctgtgtgat agccaccatt ttgtgatcga
22201 ttctgctcct gattgcctgt tatttttgta aaacattcct caaaaactct gtggggtttc
22261 ttgtttgctt tgctttctag aaataattga aaattcttaa aactttcaca gttgctcaaa
22321 tgtaatttct gtcatcctca atttagaaac cagtatgttg ccctttctaa tcctctctct
22381 ctctctctct ctctctctct ctcacWcWca cacacacaca cacacacaca cacacacaca
22441 cacacacaca ctttctgaat taatttggac tgcctggaaa atggtaaatg tttctgtggc
22501 tgcatagcag gcatgtttct taacacaata taggatagtt tattgtattt atagtgtatt
22561 ttgtttctaa aattactcaa aatttcttga agatgtgggc tatttctgaa ggtcaagggt
22621 ctccatttct acttaatttc tgagctcctc agcatctgta gctatatccg cctgctccag
22681 tttgWaaaag ttctttaaaa cacaaactcc aaccttggag gttttgctta caccccaaat
22741 cacatggttg gttttctttt gtcaagaaga aagaagaggc tggacccaca cctattaacg
22801 taaggacaat gcccaaagtc aaagtccagg gaaagactgt ttcacacttg agaatcaaac
22861 cacatttctg tttgacttgg tgcaaataga catattgttg acctgtcctt tcatactgct
22921 tttctacctt ctagaagtgt ggcctctccc tcactgccag tatgtcagat atttcaagtg
22981 ttatttatca ctttctttct ttctttcttt tttttttttt tttttttttt gacgcagtct
23041 cgctctgtta cccaggctgg agtgcagtgg tgtgatctcg gctcactgca acctctgcct
23101 cccgggttca agtgattctt gtgcctcagc ctcctgagta gctgggattt taggtgcgcg
23161 ccaccacacc cagctaatgt tttgtatttt tagtagagac agcgttttgc catgttaccc
23221 aggctggtct tgaactcctg ggctcaggca gtccacccac ctcagcctcc caaagtgcta
23281 ggattagaga tgtgagccac tgYgcStggt catttatcac tctttcattg agatcatcgg
23341 gccacatatt gagcccttat agttatcaat ctccacactg gctcttcaag ttctctcatt
23401 tcttcatgaa attaattctc cacaactttc attaactagt tcagatagta gtttttctag
23461 tcccctgtta aactgcttct gcccaaaagc aatcaaacag acccaaaaaa tccacttaaa
23521 actatattaa taaaaaccta attacaatca taatttcctc acagtaaaaa tcttggaaaa
23581 tgcagaggag gggctgccgt gtgagaagct cctgctgtgg tgttctgacg atgtgcccgg
23641 tccacgctct acttccttag gtgggctttt gtttgttgag gctgcacagc attaatgggg
23701 aaacttattg ccggggaaaa tgtaacataa aaccaaacag tgggaaggga ctctggactg 23761 gcatctggtt caatagtctg tctccatcta ggatcatacc tgaccatcct agatggttat
23821 tcccaaaatc tgctggagga gagtccacga gttcctttag aatggaatca gtaaacaaca
23881 acaacaaaaa taagtaataa aagactgtgg gtcaatgtca gattatacaa gagatcccat
23941 ttagatggat actcaatttt ccatgatgtg attattacgc attgcatgcc tgtaccaaaa
24001 tatctcatgt accctgtaaa tatatacgcc tactatgtac ccacaaaaac taaaacataa
24061 tttaaaaaga gatcccattt aaagggacca tattgacaac ctgcagtgtt tctttttagt
24121 aagacattat ttcttaatgg aacactgtcc ttactaaaat tatcttcaag gcttatgtaa
24181 aagatgtcct aaataacaca atctaaaaag tatgtcataa tgtactccac tgtgcagtgg
24241 gcctttagaa gtgtaaaaat tccttatggt taaggtgaaa gtccgacttt taagaatgta
24301 gaagaactgg aattcagtaa ttctgaataa agattgaaca tgatacagtt cagttgttgc
24361 ttgacaccac cagagggcac tcttcacttg ctctctgaaa cagattttct tttacatccc
24421 ctcatagcta taatactctt ttgagtacct gaatatccac atgattgata aacttaccta
24481 ggaaaatttc tgactgaaaa aatgtgtaat tataagtaat gccttttgag ctcttatgca
24541 gaagacaggg gctgtcaaca cagagctcac aatactgaag agataatcag gtatttgtaa
24601 cttgtctaga aaaaagtatt tctaaaagtc ttcttgtaat aagaaaccac aggactgtaa
24661 acattcaatt acattaaata atcatactgc attattaccc catatgtttc tcccccacct
24721 ttcaagctat aagaaatata aaacttctcc caagcatggt ggctcacacc tctaatccca
24781 gtgttttgga ggccaaccca gagggatctc ttgaggccag gagttcaaga ccagcctgat
24841 taacatagtg agaccctgtg atgtggtt g gctgtttccc cacccaaatc tcatcttgaa
24901 ttgtagctct tacaattccc aggtgttgtg agagggaccc cgtgggagat aactgaatca
24g61 tggggttggg tctttcccat gctgttctca tgatagtgaa taattctcac gaaatctgat
25021 catttcataa aggggagttt ccatgcacga gctcccttct cttgtctgcc accatgggag
25081 acatgccttt catcttccac catgattgtg aggcctcccc aaccatgtgg aactgtgaRt
25141 ccactaaacc tctttcttgt gtaaaattgt ccagtctcag gtatgtcttt atcaacagca
25201 tgaaaacgga Ygaatacagc ctgattc c aaaaccttag ctgggcatga tggcttgtgt
25261 cagtaattcc agctgcttgg aaggctgagg caggaggatt gcttgagacc aggagttcga
25321 tgctgtagtg cctttgatca caccactgca ctccagcccg ggaRacacag tgagactgtc
25381 Mctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaWaagaaa tgcaagactt cttcattggg
25441 gttttattac tgaaaacttt gatgttcc tc ttctcactca gacatcttaa tagggctgcc
25501 catacttcca ttatttgaga agaaaca ta tcttgtcaaa atgctgatat cacacccagg
25561 tattctaagt atttgattta aatgtgtgtc tctagataca agttctgaaa agagttttca
25621 ggtataattt aatgaagaaa tacatctt tt accttcagct tccatttatg tatcactgat
25681 taatgtaata atagctttta cttttatagt gctttatcgg tgacatggtg ctttaaaatt
25741 taattctcac aaaaccctcc taagattaag atggcagata tcaatattcc tatattacag
25801 atgggttcag ggagattaca ttaactac tt gggcYataac ctggcttgga gctagctagg
25861 aaagacacct cagaattctg atttgaat ca ttctcttctt ccagtcacca gaaccaggca
25g21 gtaagcttcc ttctgactct ttaggaagtg ccaagaagac aaggaagtga gtaggagagt
25981 tgaaaggatc aaaatcacac accaatgtga ttgcccacat ttgcttctgt ctgaatgttt
26041 ccatccatgc cacccatttc tactagtcat tctccaaacc cactctcact ctcatcctgc
26101 tccactgtgt ttctctggtc ttgtttgttt tttgttttga gacagagtct tactctgctg
26161 cacaggctgg agtgcagtgg cacaatctcg gctcactgca acctccgcct tccRggttca
26221 agcgattctc ctgcctcagc ctcccaagta gctgggatta caggtacatg ccgccatgcc
26281 cggctaattt ttgtattttt agtagagatg gggtttcacc atgttgccca ggatggtctc
26341 aatctcctga cttcgtgatc cgcccacctt ggcctcccaa agtgctggga ttacaggagt
26401 gagccaccgc acccggcctc ttcttttttt tttttttgac agagttttgg ttttgttgcc
26461 caggctggag tgcaatggtg caatctcagc tcactgctgc aacctctacc tcccaggttc
26521 aagtgattct cctgcctcgg cctcctgagt agctgggatt ataggtgcgc accatgcctg
26581 gctaattttt gtatttttag tagagacgga gtttcaccat gttggccagg ctggtctgga
26641 actcctgact caagtgatcc acctgctgcg gcctcccaaa gtgttgggat tacaggcgtg
26701 agccactgcg cctggccgtg tttcttacag tgggaagcaa ggctatgaat gcactagcct
26761 gcgaagcctg gacctgccag gagttccacc caatcacctg gcatgtttgt gcaagggaag
26821 ctcctggacc tcaccccaga ccagagtttc tcaaccttcc tatccatatg aatcacctgg
26881 gagcttttaa gactcccaat gcccagatga atggcatcag aatctttaat cccaacgtgc
26941 agcccaggct aaacccactg tcccggcagg tgcattgtgt cagtatctgt gagggtgggc
27001 tcttggagct agacttttaa ctggttccct gagtgaccgt tttataaaaa gtctgaaaac
27061 tactggccag gagccaataa atacaagt tg cttttaactg gactgtgaac aagaatacgt
27121 gggttctagt ttttcttggg ttcaattttc ctggctgtgt ttttcatctg cccaatgggg
27181 gcagggggtg gactcaaaca atcagacctc aaagtggtca agaRgacctc aaaatgtggt
27241 ccttaacagc agcagcagca tcctgccccg gcaacatggc aaaacctcat ctctacaaaa
27301 aatacaaaaa ttagccaggc gtggtggtgc gtgcctgtat acccagcttc ttgggaggct
27361 gaggtggtag gatcgcttga agccaggaga tcaaggctgc agtgagctgt gatagcgcca
27421 cggcactcca gcctggacaa cagagggagg ctctgtctca aaataaaaag aaagttatcc
27481 tcagcataac ttttttggat caagaggtga ccaataatca cagacRtctg agtgctagca
27541 agggtctgag gaggttcaga acttccttgt ccttggtcag gtcacaatgc tcctgtaaac
27601 ctttaacaaa atagttgatt tgctttttaa aatatatata cttccccttt attcccagag 27661 ctggtttcaa aagctacagg attgctgttt ttgtgtttta tcttagttct ctaaaattat
27721 cctaggctac gtgcaggaat gggtacaggc cctttaaaca aatggagtta gttgtgttag
27781 ttcttttctt gtttcactgt tacaccagtg ctttccatcc actggctgcc tcagagaggt
27841 ctctgcagcc tcctctctgc ccagtgcttt ctggagccac ttgtctaagt tggaattggc
27901 tcttctctct gccccaggca aacaggtcca gagYgattgc agctgagagt gtgggccgcc
27961 catgcctcca gccatttctg ctgtaagcag aaggagcctt ggtaataatc ccctgccctg
28021 tccgtcctgt gggtcctggc actgaccttt acaaggctct ttacaaggac tgtggctgcc
28081 aagattccag aaggcttaag gattcgactt gacaaaggaa aaagggaaag aggaggacaa
28141 acatgtactg ggtgcaagct atgtgttagg aaaggttcga gtgtacatgt gaggacacag
28201 tggctctgca ggcttcacaa tttgcctaag atcacactgt cagagccggc actcagaacc
28261 gcttctgtcc cacctccaag ccacgtccag gacaggactc tgcctccttt ttcaggcctg
28321 tgcttttcag ctgcttccat ctatgaggca agtggaggta aacaatgtag ataagaaatc
28381 agtttgggac aaaatatact aggaccccat tttttcscag gaattggtaa tcattttaaa
28441 ggccaatgtc agattttaat tttttttcct aagaaaatgc ccctctatat aaatacatgt
28501 acaaagaata gaaagtctta cctttttcta ttttagcatg aaaactcctY gataacctaa
28561 ggaaaggagc tgggaaccag atacactggt ggcctcacac tcaacctcca ggggcacggg
28621 agagaaagag ggctgcagac aggcaggcct cagtctgagg ggtccaggag gaagtcccgg
28681 ctttgtgact tgaattgtct tggtaaactc aatctatttg agcttcagtt tcctcctctg
28741 caaagtggtg atcataataa ctaccttgca gaattgttgt gaaaatacta aatcatgtat
28801 tttaaatgca gcctctggta aataataggc actcaataca tgctgttctc actatctccc
28861 attacaccta attgttctta ctaacaaaac atatcagcac taataagaaa agttagaaga
28921 gatcaggtga gaacaacaaa agtagtggga agcacgttga aaaaaattag gtctccagga
28981 cgacagaagc gatttttttt tttttttttg agatRgggtc tcactccgtt gcccagagtg
29041 cactggagtg cagtggcatg atctcgactc actgca-agct ccgcctccca ggctcaagta
29101 atcctctcac cccaacctcc caagtagctg agattagagg catgcactac cacgcctggc
29161 tcatttttgt attttttttg tagagacagg atttcgccat gttggccagg ctggtcttga
29221 actcctgggc tcaagggatc tccctgcctc agcctcccaa agccacctcc ttgagattac
29281 aggcgtgagc caccacaccc ggcctacaga aacaatttta agagaagtaa tgtcatagca
29341 gatgagtgaa ttgtagttct gttttctgca cagtgt-agct ggcctgctgg gaggttgaac
2g401 ctgaggtttg ttccctgtct gagatccttc tgcggtcttg cctcagccag tctctacaca
29461 aatggaataa ttataatgta gtcaccaaca gttgtgεaaca gctcagtacg ctttcattat
29521 ttgcagataa atatcaagaa ttaaatggct accatc-acct ccctgtccaa ggtccctttt
29581 ataagagctg ttttacagtc gtgggacctc cattgactca gatgtgacat aatttagctc
29641 agttcaaacc acttttggtt ctgttggcct gccaatcaag gagtcagagg gtaaaatcct
29701 gaatcaagtt gtcctcctgg gagcaggccc tgtgcactgg cccagcaatg ataagcacca
29761 tggcatttaa caggcagctg ggacgagcga atagacgaag aaaatcagaa agacataact
29821 aaaagtggga aagaggtaaa ttttctcatg acaggatgaa gaagaaggct gggagaacKt
29881 ggaagtcagt gggatatatt tgtccttggc gaatagcaag aaaatattaa cgtagtgttt
29941 aatatccagg atccagctgg gcacagtggc tcacacttRt aatcctagca ctttgggagg
30001 ccaaggcagg cagatcgctt gagttcaggR gttcaagacc agcctgggaa catggtgaga
30061 cctccatctc aacaaaaaat acaaaaatta gcggggcata gtggcacacg cctgtagtcc
30121 cagcttctcg ggaggccgag gtgggaggat cactgg-accc tggcaggtcg aggctacagt
30181 aagctgagat cgcaccactg cactccagcc tggaaaεacag agcaagagcc tgtctcaaaa
30241 acaaacaaac aaaatacaaa aaacacaaaa caaaatccaa gacccagtgg tagagcaacc
30301 aagaggacgc tgctatagat gacatgggaa ctgtga-acat ggcccaaaac tggaatgaga
30361 acaaggccta agcatagagt aggagtagaa taagtagaaa ataagtcggt ttctcagagt
30421 tgaagacaca gcctgagaag catagtgaga tcccatctct accaaaaaaa aaaaaaaaat
30481 tagccaggca tggtggtgca cccttgtggt cccagctatt ggagaagctg atctgggagg
30541 atcacttgaa tccagaagtt caaagctgca atgagctgtg atcgYgccac tgcactccag
30601 cctgggcaac agagcaagaa cctgtctcta aaaaaaaaaa aaaaattaac cagggttgta
30661 aggcagaact aggaaagtga acagaccaca tgtgtttggg acctgccgac aatgtgacct
30721 tgggtcagtc acttaccgtc tctgtaccca ccttctctcc cttctaaaaa ggggacacag
30781 ggcctgccct cccacattga cagtactgtt gacggttcaa atagataagt gaaagagcat
30841 tgctagattc aacgatgatc tgaagagaca ttgagaccta agcaaacgtc cctgccttgg
30901 ctgccataca accagccata ttgtgtgcat aaattcttgg ccacagaggg cagcaaagga
30961 gggaagagca gatccacaga ggtgtgggag tttaccctgg gggtaccgct ggatggagaa
31021 gtgcgggcat tttgggcaga ggtgggctca cgtgtgatga gttcagggga tggagaagtc
31081 actgtcttgg ctgggtgcgg gtgactgggt atgggaaggg ccttggtggc cgtgcagaga
31141 gtgcggcctt ttctctgcag gaaaggaagc tccatcagaa ggttttcaat tctgttggca
31201 aattttcaga ttattctgat agcagcacaa aggtcgactg gaaaaagtga ggccagaggt
31261 ggagaaacaa ggtggggttc tattgcagga accaggggag agccacaggg gctagaaaca
31321 gaggcactta gagaatgatg aaattcatca ttctgcttaa aaataataac ttattacatg
31381 ttaacatgaa gaacgttttt ctatttataa aatttataaa attactattt tataaaacaa
31441 aaaagtgtag agtggcattg ttttatgctt ttgcaattct agaggtgtgg ctaaatacaa
31501 gagctggatt ttcacatctg ctctgcattc agtagattgt aacatatatc gttttggttg 31561 aagtatatga agaaaatcta gcctcacaca aattttggaa aagggaggag tacagagtta
31621 agtactttaa taatcttgag ataattgtgg attttttttt tttttttttg agacagagtc
31681 ttgctctgtc acccaggctg gagtgcagtg gcatgatctc tgctcactgc agcttccgtc
31741 tcctgagttc caSagattct cttgagtagc tgggatt-aca ggcgcatgcc accacacctg
31801 gctaattttt gtacttttag tagaggtggg gttttgtcat gttgccctgc ctggtcttga
31861 attcctggcc ttaagtgatc cacccacctt aggctcccca aagtgttggg attacaggtg
31921 tgagccacca tgcYgggcca actgtggcta ttcttgatac tacagaaaac tctataatag
31981 tttcgttttt ctttttttta aggttagtca agtgaagcag tgggagtgga aaaggaacaa
32041 tctttcttaa aggttgtttg cagtgtggag tccaaaaccc tgttaatggc agttttgtgc
32101 tgctgcactg gtctagcttg tgcttggaat agatcttεata tccatgtgtg tgactttaca
32161 acatcatgtg ttgaccattt aaaaaatact ggctcactta tgcggatctt tcaaatgtta
32221 acacatttcg aaataaaaga tcaaaaattc actcatttat tattattcat tcattcatgg
32281 gggggcgagg gatgaggaaa agaaaaaacc ttaactagaa aaatctttat gtattaggaa
32341 gctggtgaac tcacagtgac gtctccaact tggaaatctg tatcttcagc ccagatccct
32401 tcactgagtt ccaggctgac ttatccaatt gcttgcttga catcttttca ttattctcaa
32461 ggcccctaga acttagcatg aagaaaacat actcaggctt tgcattcaaa cctggcgctc
32521 tgcgatgttc ctggccagag aatcaccagc agtaacataa gccagaaatc tccgacatgc
32581 tcctctcact caccaccagt tctgctccca caaatagcca agtcctgtca gctttatctt
32641 ctggtgggct gtagccatgt ctgtctacag aaaaccccca agtggacatc actggaaact
32701 cccagctctt acagcacagc cttaggtaag gggaagctga ccaaaagctg gctcagcacg
32761 aagttcaggg ctggaaaccc agacatcagg cctagatgcc atggcctgtt gagtgacaga
32821 attaattcct ctcatggtat aagatgctcc ttccatttgg gcctatcatt gaggctgact
32881 agggtgggtg tgttagatgc caaggacttg ccactcaagg ccaaaagatg ggctgtcaag
32941 tttccattcc aatatctagg acagctgatg ggagaaaacg tgggtttctc aaagaataga
33001 aagactgtcc ccctcatcca ccacagaaca gatccaggga ggttttctga ctccttcatg
33061 tgactcctca tattgttgaa tcttaggaaa ctagaaggga gtgaatgttc agatgcaata
33121 gaaaaaaagc tgaagcccac taagtcccat caataaaact ctgaaggctt ctccattgct
33181 gcatctagtc aacactgtct acactgcctt ctggccattt ttttttNNca cagtcaaagc
33241 agccaagatg gcaggacctt tgaagtcagg tatgaccgac ccacaagcac cgcccctgct
33301 ggtctgctca gaatacaatg gcctgcacca ggcccatccc cacaaccttg gcctttgggc
33361 atgacattcg aacaagctag atatatgtaa gaggaatgaa ataaaaaata cacacatttt
33421 ctaagtaaga aatttatttg atcaaatggc aatatatgaa gatattttaa actataaggc
33481 tctatccaga caaaaagcat ctttttataa agtaagtgtt atcaatttaa atggcaccta
33541 aaatcaaaga atgagtttcc tataaatgtc tgtataaagc tttcataaaa tcctcatgta
33601 ttttaaaact aggttgcaag tataacagaa aaacctataa atagtactta aaagcaggtt
33661 tcttaaaatt tatgacacct acagtgtgtc actatagaca gagtattcgg ggggctctgt
33721 gacaatcaaa catggctgcc atgagtaagg gagcgtg cc cctgatgagc agaaccgaag
33781 cagtgattat gcctcagcct cgagctcccc gcacagcatc ctaccattcc aaattcttgg
33841 gactttgagt tgagttgaga attactacaa gaggaggtta ggaaaccagg attggaaaga
33901 gggaagggag aggaaaccaa ggcatgccag gatcaaagat atctataaag cagctttata
33961 aatgaccaag aaaatgggtt tctaaaaaac gcaaaatggt gaggccttgg ggctgcaacg
34021 tggcatctgt gaagaggacg acgccacgcc cgctgggaag ggctgacctg catgccaggt
34081 gcttggcttg gagccaccac acgcaacagc atgaaacttt ctctggagtg ccaagtcatt
34141 acctggaaac actggggaca ggtcagtgtg tagcttatac cagctttccc caaagatttt
34201 tccagcaacc aagtgactca gcaaccaagt gactctgtct ttggggccgt gatgggagct
34261 gacatggagg aatctgcagc tccaggttct aagatcagga gagcttcaga caagtgggaa
34321 aaccagatat aaagagggtg acatacacac actgttagca gcaaaacgca aaggtgtcca
34381 atgattaaaa tgaaattgag tgatagggag aaatggagaa gattccagag tgtcagggat
34441 agtaactgaa aataattata tagcacccat tattactaat ttaagatata taagcatcac
34501 tgcggattta tatagtgtct atgctattag tttagt aat ataaatattt atgagggctt
34561 tcaaaatatt ttaaatgaca tatacattct aatataaata ttacactcca gattcataca
34621 actgagttga tgttacattt aaagtagtag atttggggtt gtatatggag taacttttgc
34681 agaccatttt ctgaactttg atcattcagc taagtaaagg ccaaaaaaca caggaagcat
34741 cttattggga actttggcag caaacatgtt tttatctatg tatttatgca ttatacaaag
34801 atacacttat tcatttgtat aaatgaattt aaagtac tec ataggagatc ttacacttaa
34861 aacacttttc tgtcttctta tctgcttctt tgagatc aag tctatatggg aggcttcttc
34921 cttagaggtg tgtgtttaaa aatagtctca cgtttcccat tcaggctaag tggctctttt
34981 aagattccta atcttgaggt tacaatcttc acattgagac actgatacac acacatactt
35041 taataaaaac agcaaatggt cttatatcac ctacttt tag cagtgtgctt ttaaaacagg
35101 tttgttccca gcattacaga aaataatctc caaacacatg cattactttc tactcaggga
35161 aggatgttac aYctaatgac tgtatagagt gattttg-taa attagtctta tgcgcgtgta
35221 aactaaatgg gctgcccaac ttaaccccaa tggttaaagg aaagtagtct cggcactatg
35281 acatcacagt tacacctgtg ctctcaggta cagggcgraaa gtgagagcga gagcgcacga
35341 gagagttcaa cctgagagag ctttataatt tcaagcσtag gctgtcattc acctttgctt
35401 catttctcca aaacaagctc ctaatttagc tacctga-aga gactgctgca gcagtacagt 35461 gaaagcagcc tttttttgaa atagggtctc actctgttgc ccaggctgga gtgcagtggt 35521 gtgatctgtg ctcactgcaa cctcaacctc ccaggttcaa gtgaacctcc cacctcagcc 35581 ttctgagtag ctgggactac aggtatgtac caccacaccc agctaatttt ttttgtagag 35641 atggggttta gccatgttgc ccaggctggt cttgaactcc tgggcttaag caatccaccc 35701 accttggccc cccaaagtgc tgtgattaca tgtgtgagcc actgtgtcca gtcgacagta 35761 gcctttttac tgtgatgtca ataaaccaac atctgaagat gacaggaact ggattcagag 35821 tctgtgtaaa ttttctcaat gagtgaccga gcatgtaaat ttaactcaaa tgaaattact 35881 acaataattg ctttaaaaac atatttagga aaatgaggtg accctagatg agcttattta 35941 tatgtctcct ctaacagaaa tcacctcatg gtaagagttg cttcttttgg ctcagttcac 36001 ctgagaacaa cttcatttgg aacttttctt agccatttaa cgtaacagga gactgactca 36061 aagttggttc tagtggatga agcaaaatag acatgaccag catggccaat caatgagctt 36121 cattcaacgg agcgtcctgg ccaagtgcca cagccacgct ggccagacac actgaccagt 36181 tacgcatttc ccaccagcca aatgccactg tttactaaac catgatttca gtaggaaaaa 36241 gagctctgga atcaaggccc tcactgcagt acctgggtgg ggtgtccatg gcctggcctg 36301 tagtaaaccc tctgccttcc actgtgttca cgttcgcagc tctggcsctg gggcatctgg 36361 cactttttta aaagagatgt ctctgcctct agatgaacaa tctggasctt cagaatacag 36421 atcaaagaat gaagcagatc tttcagtggc ctcatcctgt ggcacctgcc cagccattta 36481 actcccctgt cctcccaccc tacataaagt gtttcccaca ccagagtgtg cacaacatgg 36541 tgactccaaa tcccaaggaa gttgagttta gctggaggtt aaccccgtgc tcagaaaccc 36601 atctgttatc tttccagctt caggtttcag agcagtttat aaatggcata atacaagggt 36661 aatgtgagta aaatctgaga gttttgttca ttatcaagtt atccacacag tgcccaatta 36721 agtaaggtga tctagtggag taatacttct ggcctgggag aaaaataaaa ccagtcaaat 36781 cacacctttc tctaaaatgt cccattaaaa aaatatggaa taggccgggc gcggtggctc 36841 acgcctgtaa tcccagcact ctgggaggcc aaggtgggcg gatcacgagg tcaggagatc 36901 Ragaccatcc tggctaacac Rgtgaaaccc cRtctctact aaaaatacaa aaaaattagc 36961 tgggcgcggt ggcaggtgcc tgtagtccca gctactcggg aggctgaggc aggagagtgg 37021 cgtgaatcca ggaggtggag tttgcagtga gctgagaatg Ygccactaca ctccagcctg 37081 ggcgacagag tgaaactcca tctcaaaaaa aaaaaaaatt atatgtεatgt gtgtatgtat 37141 atatatgtat atatatatat atatgtatgt atgtatgtgt gtgtgtgtgt gtgtgtgtgt 37201 gtgtgtatat atggaataaa gtttgagatt ccctgctttt tcatgttacc ttagcctcaa 37261 ttttaaactt acattgtttg ttaaaattat caaatggaca acctcattgc tatggaacaa 37321 aaaagactgt gaggaaaaag aatcataact tggaaaaaaa taagtg-aaaa ggcattgaga 37381 gattgctaag atttgttaag ttaaaacaat aatatatcta gaaaagεactg tgaaaatata 37441 tatctcaaaa gagaacaagg catagtcaga aggctcagta aaacaattac tttaaaagct 37501 gactaataaa aagggtaagt gaaagaactc ttccatcctt gacccttcct cacttcctcc 37561 ctccgactcY accagtctgg atgcactaaa gcagaataac ctaaaagcca tgaaaaagtg 37621 ctggtatttt tcaggatctc ttcaagacac cttccgtctt ggtaacctga attctctctc 37681 tgatcaaggc agctgatgga ctttcaatgt atttggagat gccggttcaa aaacgtcatc 37741 atcatcttct gctccttctt ctatcggttt catcttggca gaggctcgct ggtgtgggga 37801 tgacacatct gtggaaagat acaggaggga aaaccactga atgcacaatc tacccagacc 37861 ctggtgtgat atatcaatta taaattccaa ctggaaaata aaactgtagg aatctatcac 37921 tagcagcacc aagaacacaa tttccataaa ccattctatt tcaatccagc atctcaataa 37981 aataaccaag tcaagaagag actctcagtc aggagcacag atgagggaca gattccaccg 38041 catgtgcttg gatgatctga gcttctcaaa tatattcagt tcccaggggt ttgccccaca 38101 gtctgcttag gactcagaac gcatgttcct acattaatat catacatggg ggcttgagtc 38161 tcatattagc ccttgaaagt tgatttaact cctaatttcc ccaaagεaata cttctattcc 38221 aaaattatgg aacctaatca ccatctgtaa tatcacctaa aacatttctt gcctccacca 38281 tggagtccag ccacccactg ggcttacacg caaaggagac aggggaagag gaagaaaggc 38341 caggcattca ggagggacaa gccaagtaga ggaaacgcaa tcccaggcag cagcaggaga 38401 aaaggcaacc ccagggcctt ttaggatgcc atttaatcaa aggaaccagg cagcaattca 38461 ttcattcagt cactcactgg ttcatgcatt caccaaatgg ttatcaεagca tctaccatat 38521 aatggatacc atgcttgatg tagaagaaaa tactatctaa aagtaagagt agaagtcatt 38581 atcaaaaggc ctctcaaggt gcctaatgag cagctaacgt gactgcataa actcccctcc 38641 ttacagtcac caccatcact gtcaggatcc atgttgtccg ggtttccacc tgctctgccc 38701 acacccatat cttcgctacc caatcacagg gtggagtggc attcMggcag cccacaaatg 38761 ctgaactcag ctggggagaa ggttgatggt ggagggatac cgggtg-aaac ctggctcttt 38821 aaatacatgc tcacagcaaa agcgagtgga ggatctatta agacatgaag cagatctgct 38881 acaagatgac cacagaagtt tgtcaagatc agctgtcatt cactggcagg agtcaggagc 38941 agacagctgg gttggccagc acagggagaW tgccacaacc agcaaggagg gccaagggct 39001 atgagcatgt cacacggctg ctcctggagg gaggctgaga cagcggcaaa ggctttgccc 39061 tggcactcag ccatgaacga gtggtcattc ctggcccctg gtatggcaca gggggaggga 39121 gcatgcagag tggtcaagac cagaggctca gcaaacagtt ccagagttca aatccctact 39181 ctgcaacctg cactcaatta ctataccttt ctaggcctct gtttccatat ctataaaaag 39241 gggatattct taggatctgc tccatgggat tgttaggagg attaaacaga ataatgcata 39301 ggatgtactt agcagggtgt tgggcctata gaacatgtga ctaaatgtca tttcttatta 39361 actgtacagt cactgccgta catctgggga aatgctacca ccagtcacat cctctaacat
39421 aaaaaaatat gcagggctag actgtggtac agctaatgta tactcgctgt atatatacgg
39481 aaattgttca cttacagaca tttacagcaa aaatactgag tctcttgaat gacaactatt
39541 gacataaact gtagaaaaga agcatctaat aaaatggtcc aagaacccaa ttctgcacag
39601 ggcacagcat gggaagttct caggcgagtt cttccccttt cccatgcagg tgacatcaaa
39661 cacacgaaac acaacctcta cttcaatgtc tattcaaatg gcaatgaatt ctatctgtgc
39721 gaccYtggac aagttacttc tttgtgcctt aatttcctta cctgtaaaat aggaataata
39781 agaacagcac ctatttcata tggttgttat aaggataaaa caacttgata tttgtaaagt
39841 tattagatca gtgcctggga tgtaataacc actttgtaaa tatttgtaag aacataaaaa
39901 tcaattacta tggtctttgg aaggctatgg acttaataat gagaaaattt gttaaaattc
39 61 atcattgctc ataagaatgg ccaataaagg aaatgggcct tgtgctcaaa tgtgggtttg
40021 tgtttctcaa tcttagctct cttgagtgtg gcaaaattgt ctttaaaaaM aaaaaaaaaa
40081 gccctggttt ccatcatatt tttagcctta agttatcatt gggtctcata aatattaact
40141 taggctgagt atctacaatg agacaaaact ctcagaacaa acaataagat ggcatgtcta
40201 agagcattaa atcaagtcaa taatatatag tatatagaca taattgtgta acacgcttaa
40261 cagaaacata cccagtttat tctgtctgag gaagtaggac taactggttt ctagttttta
40321 agctcatcta tcataccagg aaggacatcc tacagttata ttgaggcagg tatctatact
40381 ctggagccac aatggtatct gaccctccca actctctcac ctatactttg catttttttt
40441 cactgagaga aaatgaaggS aggactcaac acaaatggaa atggttaagt gagaacttcc
40501 caagagcttt cagcttttct gtgaaagaat ttattctgct cccaccatat ttgctggggc
40561 agaagaagag ctatggaact tactatataa cattaaaagg ataatgagag tgattcacaa
40621 tccttagggt gacatccagg gttctccaag ttgggtctcc ctccctcttc cagtccaagc
40681 tcttgcaaac tcactgctct tcaaatccag cccatcctcc tcttttcctc ttgccttttt
40741 tccctctact tggaatggtt cctccactcc catctctaac caccaaattc ccattgtttc
40801 ctcaagcagg attcaaactc cacctccttc atgtgtaacc ctccatgact cctgtgggaa
40861 gattctaccc tcttcatctc aataacttca gcccttccac attctgtgta acattgtggt
40g21 tatagcattt gcatctcttc cttattagaa aacaggcatc ttgagtgctg taaccaaggc
40981 ctctttcctc ctgcagcctc acagaattac tccacacata gtcaggacct tgataatgtc
41041 cttaagtaca cagtgatgaa aaaatccctc ctctgaaagg ccacataggg aacctcagaa
41101 aggatcctga ggatgaggga aaaagacatg gacatcacct ttaatttctg gcgggtctcc
41161 cagtggggca ccaccagcat tcctcaagcg caggcaggcc tcagggtcca gtaaacctca
41221 ttaggaaaag ggactgtcat cactctactt tgtagcatgt cccctgaagg aaatcacttt
41281 tgtagaattg attcgacact gcttagggca tggacaagaa caccgttctc tcaaaggaat
41341 atcaataggc ttaatagcac catcacctgc tacaatgttt tcatccaatc agtaaaagga
41401 atcagggagt gaccacaagg tgctaggaca atgggttaaa tgttggggaa ataaaaagga
41461 atcacacccR gtctttcatg ctgtcttatt ttatttctca gaaactcaaa gcacttttca
41521 gagcaattca ccctcaccac atctgtacta ttatttctac tRtatattca gaagctaaaa
41581 caaagacatc cgtgaaagaa aacagagagg ggtggctgcc atgaatgagσ ttatttctta
41641 ccagggtgtg aaccacttag aacacatcct aggaggataa accagggagt cctaagggcc
41701 tggaaagatg gaatttttct gcaaaagttc ttgattcact ttcatttcaa- gctttgtggc
41761 tgagaatctg caatcccccc ccaactccct gtccttataa caacattgcc. ttgttgctct
41821 ttttccacct tggtagacac actggcagac aggagcacag cccaacctgt cacttccagg
41881 gactacctgg tgccagctgg ctgccaaccc ctcgcttgga attagaatca- cggagagtgt
41941 ccactctttg taccaRcccc agttagcctg gccttctgta ccattgagggr ccaagtataa
42001 cattcacatc caggaagaca aaaggatcac ctgccctgcc tcggaaWctgr caactgtcat
42061 ggccaccaga aagcccagct ttgaggagtg aggggctcac ctggccccta- gacatggggc
42121 tctctggcct catcaggaga cttactggtt caatggaaag attcagagtc catccctata
42181 tagctggaaa ttatttcttt gaacccctaa tacatccaaa accaatttgt agtaagaaca
42241 agaaaaagag ggaatattat atttcaaggg aatgctcttR catttcacaa. gttgaacatt
42301 aataaataac ttctacaggt ttgcctggtt tttcattaat tttacgtact gatagatRtc
42361 agaaatttgc ccagaggccc aactatcttc cagagatgtg agaacatgagj aggagagagg
42421 aagaaataga gcttatcttt agttaagtga tttttcaaat σacttttgtt cttcaaggag
42481 gttactgtaa ggttcatgat ctctgtagaa tgctttactt ttcatttatt gccaattgta
42541 gaggggcaaa taatttcata tccataaatt tcccagaaaa ttgattctta. gttttctatt
42601 aaaactattt ttacagttgg gaggcagaSt ggttaactcc atcctgttgt atttattgtg
42661 atcaggaaaa gacttctgta gtaatttttt ttctgttagc tataatcacc ttccacctac
42721 cagttaatac attttattat aaaagtatat aaacagtatc atactgaact gaaacccaga
42781 cttaacaggt gtgaaactgt taaacagtta cgtcaagagt tactgttgct ggagggatgt
42841 ttcatattac accaagtggc aaaaaagtcc tctgcacaaa ggacttccat aaggaccaag
42901 gcatcgagaa ggtgcagcca gtggagcaca attgtgctct ggggtgtctg ccacactcgc
42961 agtatgttca ggtgggaaag agaactgtag caccaggctg ccgtgctgag ggtgagaaag
43021 aaaaactcca agtcaaggac cctgagcaca tgcggaagac tgggacagca gcgaRagtcc
43081 tgagcgaaac agtggacacc tttgctcctg ccagatggca gggggtgacc acaccgtggg
43141 ctcccacaag gggattcaga tacggccagc agagtctctc ctgggcagaεa. ctgttcagat
43201 ggcagccagg gctgggtgct ggttagggag gaggggagcc cattgttaag acccactgca 43261 tgtccctgag ggtcactggc tgcaagggca aacaaaacat tgacctccat ggagggcggg
43321 cttgggctgc cctgcagatc cttctctgtc ttccagagtc ttgagttaaa gaaccacaga
43381 aggcctNaaa aaMctttttt ttagtataaa atatttgtgg gtacatagtg gatgtatRta
43441 tttatgagtt acatgagata ctttgataca ggaatgcaac gtgaaatgat tatatcaggg
43501 taaataggct atccatcacc tcaagcattt atcctttgtg ttacaaacaa tccaacttac
43561 tcttttagtt attttaaaaa tgtatattat tttttactat agtcatcctg ttgtgctagc
43621 aaatactagg tcttattcat tctttctacc tattttttgt atccattaac catctccact
43681 tcccctctac ctccccccac ccccattacc ctttccagcc tctgataacc atccttccac
43741 tctctctgtc cttgagttca gttcttttag tttttaactt ctacaaatat gtgagaacat
43801 gttaagtttg tctttctgtg cctggtttat ttcacttaac ataatgagag gaggcctttt
43861 catacatgaa ccagggagct cttacatgac aatcagtcaa atctctggca tacagggtaa
43921 gaaaaaatga ggtaagattc tgtccctatt aagcttattt ctatttcagt gtgcttctaa
43981 ttacaggaga gcctgaaggc ctctcctagg aagtaaaagt aaacagacat atttgttttt
44041 cttaaatcca gagtgaaggt catgcctgtt ccagaggatg aacaaactac ctcaaatctg
44101 agcttcaaat aagtRgagta ccacgatgtg aaatctgtca ggtgactttt atccttgctt
44161 aagaaataca ctttttaaaa aggagcaaca tttctgtaag ctaatataag gtgctaagat
44221 tttcttttct cccctgttaa ctttaatgac gttttctcca tttctttcaa aatgttatta
44281 tttttattat gtttaaccat ctggccaact gctttagcaa gtaattaaaa acctacagga
44341 gtttaaaatt taattagatt gtacaatttt tgaagaatgg gaatgtggaa ggatttaatg
44401 gctttttttt tcctggaaag aattcttttc ctgtctttgc ttattatatc ctaagatttt
44461 ttttaattga ggaaactgag tttgaattga agctttctga acaataatac taaagagtag
44521 ctttggcttg tgcaccRaat gtttccttta atacactcag caccagcact gaggaactca
44581 ggcaaagcgt acaaaattag ggcaaatgcg gaggttgaag tagcttagtg gttcctgtga
44641 tgaggtctac tctgccccaa gagcacgttc tcagagcagt ccctaactac tcggatggac
44701 catcagggcc gtgagctgta cagcgcgcaa ggtgtggtgt gagcagccaa ggaggagcaa
44761 aagtcccgca gcctcttcct gctcacaaag aagaagatac agggtagagg agaaggtgaa
44821 tgaacccagg agaagagtga gggcaggatt caggctggca gccatgcaac agctcagaga
44881 ataatccatc caggatgagg ctggaggacg gcaggctctg taaggaaagt ctctgggaaa
44941 aatgggacac agaactggga gaaaggatat aaggacagaa aagacaacga taaggaaaaa
45001 ggaaggcaac tagaaatgcc cgtagaaaca ataagcagta tgaaaaggca gggttcaaat
45061 agaggacaac cactcagaga cttgaagaaa aaatgaaatg ggtttcacct aaaagacaga
45121 atgaggaaga agcctgaaga tcccagggat atggtgaata agatgtgtcc cacaacagca
45181 aggcaatgaa acaactttag gggaaaaaag agagtcaagg cataaagtaa accgtggcat
45241 gattttcatg ttgtatatga aagaagaatc cacttgaact tgatttttag aacagtctcc
45301 tttgaacaga acaagagtca tgacattgga aacagaaata aatgtaagca ctgcccacta
45361 cttggttcta cgtaaagcac aataatctca acattgttta tttgtcttag actttgtgaa
45421 acaattcata gacaaaggct aattgcagtt ataaaagaga acatataact tgaccgtttc
45481 aaagtaagag acccacaaca gtttgaaggt agaaggggaa gaataagaaa gtagggatgc
45541 taatgtcctc accttttaaa acatttattt tttttgagca gggtctcact ctgtgcccag
45601 gctggaatgc agtgtcgtga tcttgactca ctgcaacctc aRcctcctcg ggctcaggtg
45661 tcctcagcct cttgagtaac tgggattaca ggcacaggca ggccatcatg ccctgctatt
45721 ttttgtattt tttgtagaga cagagttttg tcatgctggc tgggctggtc ttgaactctt
45781 gggcttaagt gatttgcccg ccttggcctc ccaaagtgcg gggactatag gagtgagcca
45841 ctgggcccag cccttaatgt cctcaccttt aaaattagtg cagcaagaaa aagaaatgga
45901 gatttaggtg tattgtttaa tgttacaaag ttaaacaata aaagaacaaa aactagtgac
45961 ttcatcatat tgagcagaaa gtggagggga agttagaagt gagctatcta cgtaggtcag
46021 tagataaagg ttactaagtc cccctagagt tggtgagaag gtagtcactt gcctataatc
46081 ccagtacttt gggaggccaa gacggacaga tcacttgagc ccaggaattt gagaccagcc
46141 tggacaatat agcaagacgt ggtctctaca aaaaatacaa aaattagcca gccatggtgg
46201 cacacaccta tagtcccagc tactcagaag gctgaggcgg gaggacatct tgagcctggg
46261 aggcgggagg acatcttgag cctgggaggc ggaagatgcg gcgagctgtg atcatgccac
46321 tgcactctag cctggatgac agagtgagac cctttctcaa aaaaaaaaaa aaaaaaagat
46381 taagtgtata aagcaataaa taacggcaca tcatttggca ctgtggttaa caactgtttc
46441 aaagtgactg ttccttggga gcaggactaa aattagcttg gaggggggtc agttcttttt
46501 ttttcactgt aaggtttttt aaccatgtga tatctatgta tattaacttg ataatttaaa
46561 caattttgac taacagacta aaaatgtaca actgtataaa ataccttcag gtaagatttt
46621 acaggtaaRa aaatgctgtg tgaggacaga ggccccctcc tggggcgagg agcagggtac
46681 tggcatgaga gagcacagcc tctactggct gggggagaca tggtcatatt cctaagccta
46741 aaaatggaaa atgaaacacc cacctcgtag ggtggttgtg aggattaaat gagaacctgg
46801 ctgaaagtgg tcaggatgtg tcagctgcta cagcagtagc tgaatatccc aaacaagttt
46861 atgctcacat tgatctccct aaactacact ttactcatct ataaaatgag ggtattgctt
46921 tctctagcca tcttggtagg tctgagaatt gttcagactc atctcccaga aacctgctgc
46981 ctaatcacac atctttctac ctctctgtac aattcatgta aagcttattg tttgtaagtc
47041 tatggttgct cacaacggga atgaaacaca aattgagctg aacagattat ttcatgaaac
47101 cagcctcgaa actaagaatg ctataatggc tttttgcgtc tttccaggta aataaatata 47161 gaagagaacc aagagaaact cattagtttc tctcagacat actggtagtc ttttcagact
47221 gcaagctaac taaatatttg taaaactagg tcatatgaca ttagtaggct gtccacaaca
47281 gcattttttt ttcttttaga cagggtctca cgctttcacc caggctggag tgcagtggca
47341 agaccatggc tcactgcagc ctagatctcc caggctaaag tggtcctctt agctcagcct
47401 cccaagtagc tgggaccaca ggcgcatgcc atcacctcca gataattaaa acaaattttt
47461 tgtagagagg gggtctcgct atgttgccca ggctcRtctt gaactcctgg ggtcMagaga
47521 tcctcctgcc ttggcctccc aaagtgctgg gattataggt gtaagccagt gtacctggcc
47581 agtgtagtac tgtcttgaca ctaataacaa acaaaatact tacaaagatc ttaataagaa
47641 acatctctct aaagatctca cagcattttt aaaaacaaca taattattat ttcatgaaaa
47701 aagacacggt ttaaactaac aagctttttc aaagatgagt tccaactgat tgcattgcct
47761 acattgtctt gtgattttaa aaaaaaatcc aaatgatagg ttatttaacc ccaattaact
47821 aaaatacagt tctgtaacat tcaaggaaac atatgtcttc ctgttaccat agcaatgcct
47881 gagctgggca gcacttacta gtgatggaat tgccaataca atccatctgt gtgaatgcat
47g41 atgttttata catgaaggga gctaagaagg agagaagatg cacaaagatg acaacaaggt
48001 gccctgacga gcaacacctt ggtccaggag ccaagagaag aaagctttcc tacatacact
48061 ggcactaaag cgttctcaca cctctcacac atcttgtccc ttcttctctt cctatctcgc
48121 tatattccat gtttgcaaac atgaaaccca gtaaatgaag caatgggaaa gtgaaagagt
48181 taaatgaact gaattatgaa ctactgaata aacagagaga atgacttttt ctcaggctgt
48241 ctcatgactt cactttcttc ccacaatttg gagtgggaat acagaatcta tgtggaaagg
48301 agtagagacc ttgctgtgga tttagcatYg tgtggcatgt ataaaagcag agtacaacat
48361 gagaaatggg agcagcagca attccattaa aacaggtcac ttagtttccc tccacctttt
48421 tctgtccgta tttctgtttc actgaacatt tgctgtgtaa agttatgaag tatatttgtc
48481 gcattactga ttgagatctt taaagtagtg cctttaccag aatttatgca aacttctaca
48541 cccaactacc ggcagatgag aaagacaaga acaccataat caccaccatg gggatgaact
48601 cagcaaaatt ccagaaggtg ggaaattcta cagctttcct actcaaagtg tagttcacag
48661 accagccaca ctggtatcac ctgggcactg gttagacctg tggactccca gacccccacc
48721 ccagcctgct acatcaggat ctttaataag atctccaggt gattcatatg cacatttaag
48781 aatctgttgt tctacaggac aaaccaaaaa accaaaacaa aaacatatgc agaaacacac
48841 acacagagac agagagacag aSagagatgg aaagggagcc ctgaggtgta gtggctgaat
48901 gcgatgtRca catgctgttc agatcgtgat tcgaaaaata attataaata ttcgtatgca
48961 tgttaatgtt taaatcgacc tagatttggg ttaatgaata ggtggaacaa tgtaaaaagg
49021 tttaaggaaa tacataaRgt atatttaatt tggtatggag tgacactgct tgtaattctN
49081 aagtaatcta actaaaagct aaatgacact ggagattatc attggataat ttcacacatt
49141 cctaagtaga accctagtaa tccagtgata agaataaggc aaaaatttta attgaaatgg
49201 attacattaa ccaatctatg aaaacctatc tgcagcacta cttgatcaca aggaaggaat
49261 caggagatga caggtttccc cagaaaagta ggtgggagtt gagaaaaagt ggcttggggc
49321 aagtcactac cttctcacca actctaggtg gactcatctg caaagaggca aataataaca
49381 gctcctgtgc ctagctcaca tagctgtcgg ttcaaatgca agaacagatg tgaaggtgac
49441 ctgtatatgg aaaaacacta gtcaactgtt acttgcattt aaaaaaacac agaggtaatc
49501 tggtctacaa gcatgagctt ttgtttttct tttctttttt ttttgataca ggtctcactc
49561 tatcacccag gcttccgtgc agtggctcta tcatggctca ctgcaacctt gacttccccg
49621 gctcaagcaa tcctctcacc tcagcctccc aagtagatgg gaccacaggc atgtatcacc
49681 atgcctggat aattttttta attttttgta gagatggggt ctcattatgt tgcccaggct
49741 ggtcttgaac tcctgggctc aagcgatcct ccagcttcaa cctcccaaag tgctgagatt
49801 acaggtgtga ggcactgtgc ctggccaagc atgagctctg gaatcagata ggatccctag
49861 gtttgtatca cagaaccagc ccccatggaa gaggggcaag tgaataagca tctcatattc
49g21 ccaatttcct catctataaa atgacctaac acccgctgta gtagactgtg ttacagtcca
49981 gctttccacc tgctgtttct cactaggccc ttcctgagca gtccctgcag aagggttaaa
50041 tgatctatcc attgatgttg gttctggcaa gtgacttctg tggcccaggg aacatgcatg
50101 gaagtggtac ttgctccttt agagcaggag ctttaacagc cagccatctt gtgaatctgc
50161 cacgactgtc ttccttctgc agttacaatg gcagtgaccc agaWggcagc tagtcctttg
50221 gctgagcccc aagagtaggg aagtgcagca cccgaccttc atgtgagctt tagttaatac
50281 cttcaaaaag ttactatgca ggccaggtgc agtggctcac gcctgaaatc ccagcacccg
50341 aggcgggtgg gatcctcctg cctcagccta ttgagtagct agaactacag gcctgcacca
50401 cgaYgcctgg catttttttt tttttNatag agacaaggtt ctcttgagcc caggagttta
50461 aggctgcagt gatctgtaat tgtaccaatg tactccagtc tgggtgacaa agtgagacca
50521 actcccatcc Yccccgccac acacacacac aaaaaaaaca aaaacaaaac aaaaacaaac
50581 aaaaaaaaac aggagattaa attcttgtat gaaaggtgat ctcccaaaat attaaaagga
50641 aaacaacatg cttatcatca aggacaagat gtcgaggcag agagaattct gtacaagcct
50701 ttattaaaat aactcgtctt taagtcttcc aacacaattt agttgccttt tcataactta
50761 ctattctttg tccaattcac tataaactgt ttaattgctt ctttaggtct tcatttcctt
50821 acaaaagctt ctgtgccatR taaaacctgt atgagctttt aacacaaact catacaactt
50881 gtattaaatt tgtatccttt tctcttgtta atctatctta tgtcaattta attctcaggt
50941 ccagccaaaa aacaacccta aaaRggaaga Rgtaaagttt tttctttcct acacaccaat
51001 tatatggcct tgtaaattcc agcctctcct gactatgcaa tacttaaaat ccctaatata 51061 atttatctaa aggcatacaa agttacaaat catttacata aagaattgtt gaatgtgttt
51121 gcatttttta aaagttaatt tggtttaaaa tacaattgga aatatgaata gtttttaatt
51181 catgcaatgg aagaatgtct gcctttttgc tatttcatat gaatttgttc aaagttttta
51241 taccatcatt cttagaataa ttcttaaagt atttaattct taatttagtt tttctcattt
51301 tacttactaa ttttcaacat ctgggttatt tgtgttactt aaaatgtttt gaaacaatct 51361 aaactatgga agaatacYgg aaaatgtgcc tcttggcagg cgtgtgaatg aggtagctca 51421 caagggtgtt gagtgatctc cttcatcttt gggaataatc catttctcag tcacttttta
51481 actcacggca ctcatactga gataaccagc cagcagcaga acacccagca tttatttgtc 51541 taccatttag taaaacattt ctgggtctag gctttcactc taactaaagt catgaaagta 51601 acaaagccaa atggcaacaa aaacaaacaa aaccaaagca aaaaaatcaa accatgtgga 51661 ctcttagagt attctggtga gccactattt tttatttttg agacggagtc tcgctctgtc 51721 gcccaggctg gagtgcagtg gcgtgatctc aactcactgc aagctccgcc tcccaggttc 51781 acgccattct cctgcctcag cctcccgagt agccaggact acaggcgcct gccaccaagc 51841 ccggctaatt ttttttgtat ttttagtaga gacggggttt caccgtatta gtcaggatgg 51901 tcttgatctc ctgacctcgt gatccgcccg cctcagcctc ccaaagtgct gatctgcccg 51961 cctcagcctc ccaaagtgct gggattacag gcgtaagcca ccatgcccag ccagtgagcc 52021 actatttaag caaagtatat ggcaaaacca gtgaacaatt tcaatttctg aaacagaaat 52081 aatagttcta aagttggctt ttagctcata tgcaatatgg gggaaatgct aaacaaaatt 52141 tgattgtttt tattgttacc tttaggttgc ctttcaaata gttacctgca aagttatttt 52201 tctaatcaaa gttgtcattt gtctatgtcc agagataccc atcagaactc tggagtagta 52261 tcagttttgg gataacttac gaagagagga catgctggag gtaccccgaa gaaactggtg 52321 caagccgtcg tcactgtcac tggagctggc tatactgttc ctcatttcca acatggagat 52381 ctgtgtgcag aggctgagct gatgttccag ctttttggct ttctacaaag caaagtttta 52441 agctttctga gaattatggg agttgaatca tacattccat ttaagcagca tgtacttttc 52501 ctagaaatac gttagtgcat ttaaaaaaaa gaatacctga tacatattag gtggccaata 52561 aacataagct atgattttta ttattagcta ttactataaa tatattataM aaaatcaaat 52621 atacttagta gcctatttat aataagctaa ataattaact gaaataagca ccagcttaat 52681 ttgataaaca gtccagataa gatgattttg aaagggcaca tatactcaat tgtcactggg 52741 taacagtact tatcacagaa acgacgtttt taaaaattct ctcttgtaat cattttaatt 52801 tctttctaaa aagatacggg aaaattaaga tcaaattgca aattgctgaa gatctatgca 52861 gctctacacc tctcctttca ctttctcgcc tgacctgaag atatgcaaga ctggaagaca 52g21 gcagggttca aaggccaact tcctgatcgc tggggtctgt cagcctttct ctgtctgcaa 52g81 acctccagct gccctgtcct ccctaactta ctccatcctc caccccctct tactccttta 53041 ccatcttcct taaaatgctc ttgatgaaga gggtgcctta tcaccataaa tgctagtccc 53101 tgacaattgt agactcctta ctaagtaaca gcaaatctaa tcattacaaa atactttctc 53161 ctctcaagat tacaagtatc cccagtacat ttaacatatg gctagttact aaaaattcag 53221 gaaaacatat ttcataaagt gaaatatacc tcatatacat atttatttaa caaaataaac 53281 tcagagaaca cttactttat catttaaggt gggatcattc aatgagtaga gcttatttgt 53341 gatgtctttt ccaataagat acctaaagat ttcatacaag aaaggttctg attccagaaa 53401 gtatgttaat ctttctcttg accagcataa aaatctgcag ttatcatctg caataatggt 53461 gacctgccaa agaaacaagc atgcaaagaa taaagtacat ctatgtatat gaattatgac 53521 tatagtgatt tagaaaacta ggaatgattt agtggacatt atcatagcaa tgatttgtca 53581 aattataaaa aaaaggagac tcaatgcaca caagcttcta cacgtataaa attatgtttt 53641 ttaaaaaagc aatctgcaga ctaaataaaa gcaaattctc tgtgtttcct tgttgttttg 53701 ttttgtgagg tctggtgaca gaagaatggc cactgtattg ataccgctgc tggagcatgt 53761 attcaactga ggatgccact ggacatatga cttacatgaa atatttcttt acaccctgta 53821 cattacaatg aagttcaaaa atacagcttc aagcagatga actaagattc atgaggcaag 53881 ttgtgaaaga ccttctgccc atccaWctct gcaaatatac actaaagact gagaaaactt 53g41 caagggccct Nggctgttgc tgatgaatac ggctggtgag ggtccttctg tcataggtgt 54001 ttctcgagtg tcacatttca aggttagatc cagggtagcc cattagagat attcacagac 54061 atccccaaat tagctcagag ctggaaatca tacccccttt ccttcagtat Kgtatgtagg 54121 aaagcagaaa ggtactataa ctgcacgaMa cagagctcaa gtatccctca aataaatccc 54181 tttgccagag tgaggggcca tgccctcacc attcagtgcc aggaagccct tcttcccatg 54241 ttaacacttc catcagttaa cacaactgca agcttcatta tggcttaaat cctatcatta
54301 aatccaagct catcagctga cacatctgcc tgttccaagc actgtgaagg cagggattgt 54361 gtatcttcac gtctgtctga atgcctgact tccaacatgg agtggtgctt aatgcatgac 54421 tgttgtatga aggacttaag caaatgaaca cacaacatgg caaaaccctg gctctataaa
54481 acatacacaa attagatgga catggtggca tgtgcctgta gtcccagcta cttgggaggc 54541 tgaggtggga ggatcacctg agcccaggaa ggtcgaggtt gcagcgagcc atgatcacac 54601 cactacactc gatcatacag tggcagcagg agacccctgg gtgacaagcg cgagacctca 54661 tctcaaaaac aaaaacaaaa caaatgaaca caaataccgc agtaggcaaa aaccaatgtc 54721 cattaaactg acatccagtc ctatctgagc ctcagagcaa atgtttctaa agaagctctg 54781 tcccctttgt cacaaaagta aacacatttc agaggacaag gggatatgta catctaccaa 54841 gacagaaaat gaaaaaccca gcttgtctcc ttacttcaac aagctgaaat ctgattgctg 54901 gcaaattaag aatgtctggc tactttaaaa agtggtgtca acattcctag gaaaaaaagc 54961 ttgtgtttat ttattatatc aaaagtagga atttccaaaa ccaaacgtat ttgtttttaa
55021 gaaatgcatc agcatctaag acttgatgaa acactaaatt tcattcattc tttcgataca
55081 ttactatgca tgtactttat gctagatact cttcaaggta tgaagttaca atggtaaata
55141 agaaagacaa gatgcttgcc ccatgaagct tacattctag tggagaagga tgataattaa
55201 taaagaaata tgacaatttc aggtggcagt aagtgttttg acaactatag aacaggggaa
55261 agtggtcgag aatgactggg ggtgacaata gcacataatg ccactcactt tgtatatgta
55321 cttttaaact ttaaggtgct ttcatatcta tcatgtaagt ggatcctcaa aaatccgttt
55381 aaaataagac aagtaatatt cttccccatt tttcagatgc caaatgagaa ggaccaaaaa
55441 actcacaaac acatattaat tagtggtaga gtggctctac aaaacacaca aaaattagcc
55501 gggcatactg gcatgtgcct acagtcccag ctacttggga ggctaagatg ggccgatcac
55561 ttSaggccag gagctcgaga ccagcctggg ccaacatggt gaaaccctgt ctctactaaa
55621 agaaaaaaaa ttagctgggt atggtggcag gcgcctgtaa tcccagctat tcaggaggct
55681 gaggcacaag aatcccttga acctgggagg cagaggttgc agtgagccga gatcgtgccg
55741 ctgcactcta gcctgggtaa cagagtgaga ctccctctca aaaaaaaaaa aaaaaaaaag
55801 tagtggtaaa gtgagcactt ttgactttca gcccaaatct attttcccac caggtcaaaa
55861 tctacccaat acacccaata ctcatcaata ccatttcata gaaagtattt ctgcctagtg
55921 actacaaggt tggctgtgca gtccatcaag agcccctcat acagagaaag gctgaacaca
55981 tgccatgaag cctacattYt agtggaggag gctgctaata aagaagtagg atcaaaaaca
56041 tggcaagatt tacaggaaga ggagtataag caaactgacc ctggggaatt cccacagacg
56101 gtatgaggtg ggtgcataaa tggaaggcaa ctgaaaaata ttcctggagt aataacagaa
56161 aagtgagcat ggtgtcctca tgagggccca gccatgcacc taagtgctaa agacagttag
56221 gactgatgtt ccttcgttgt gcaaagatgt cacccaggac tctggaaaag agtgggtgaa
56281 ggagttaaaa gaggagatgg aaatcatcta tgagatgaag aaattatatt tagatgatac
56341 ataaggctgt taacttttct tcagccatct gaattacctc aagtttccac tgaggcaatg
56401 aaacttttac aatgacactg taatttcctt agcaaattca ctttttattg atggttaaaa
56461 aattactttc gacctgttta agttattatt gaatataaaa taatagtatt caaataataa
56521 gccgtactta gttcatatga gtaacttaca ggcccataaa aacatggatt tgggccgggc
56581 gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg gatcacgagg
56641 tcaggagatc gagaccatcc cggctaaaac ggtgaaaccc cgtctctact aaaaatacaa
56701 aaaattagcc gggcgtagtg gcgggcgcct gtagtcccag ctacttggga ggctgaggcg
56761 gaagaatggc gtgaacccgg gaggcggagc ttgcagtgag ccgagatccc gccactgcac
56821 tccagcctgg cgacagagcg agactccgtc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa
56881 aaaaaaaaaa aaaaaaacat ggatttggtt ggaagccagt agttagagtg ctgactgagg
56941 tcattttact tgattcctaa tgtttcattt ctaccaaata gacagtttat ttaatgattt
57001 cctgtcacaa cagtcaagca aagtgtattt tttatgagaa tatcttataa agcaatataa
57061 gaattttaaa agtttccata aaataaattt acttcttatt aggcatttca gtagtgctat
57121 gcttgagtcc ttgtgaagaa ttttactgaa gaaataaaag caaatacggc aacagaatac
57181 ataaaaggac atctttcagg tcgagaatta gactaagcat ttgcaaacag gtttgccgtg
57241 attaccacaa ggtactggat cagttcctcc ctttagattc caaaccaatt ctacagcctg
57301 tcataaagag aagacactgg gctccaccgt aggaaacaaa ggtctctgag ggatctgcca
57361 catgtgctag aatcagaaac cgcagtgtgg caataggact ggctgactgt cctaaggaaa
57421 taatttaata ctttttgcat gcatcatact gcatttcata taccaaacac taaaatatcc
57481 tagaagtggt ctattccact gatgcttatt gagttctcct aagcactaaa ataacacaga
57541 ttcaaaagtg gcagaggaaa ttgtttcaca gctccaccaa aatatttact taatattaag
57601 ataatgtttt ctttcaatac cattaaaact tagtgttcat ttcttttaca agagcatgga
57661 catatgcctg caagacatcc ctctcccctt gaagtcaata aaactttgat ttttgggctt
57721 tgcaacacca ggacatgcta ttggctatgg gaaggcagca gcatgagata gaatacaaaa
57781 gaaaagcttg caaacagtaa agctcactta atataaaaca tctacataaa gaacaagaaa
57841 ccaaacaaaa cactactttt atcttttttt ttttttttga gatggagtct cattctgttg
57901 cccaggctgg agtgcagggg tgtgatctcg gctcactgca acctccgcct cccgagttca
57961 agtgattctc tccagcctca gcctcctgag tagctgggat tataggcacc tgccaccatg
58021 ctcagctaat ttttgtattt ttagtggaca ccaggtttca ccatgttggc caggctggtt
58081 tcaaactcct gacctcaggt gatccacccg cctcagcctc ccaaagtgcc gggattacag
58141 gtgtgggcgg ccgcgcctgg cctactttca tcttttgtaa taatactact caagattcta
58201 tcaatagtta taaacagcaa ctctgggcta taagtaccaa aatcactata agtacctagg
58261 gataacaaac tgtaagttσa gaatctgttt tctcagctct atcactatgc ttattatcat
58321 gataattact acatatttac ctgagcaaca cctgctatgc aatctcaagg gacagtcatt
58381 gagtccactt gcσttctctt tcctcctttt catcStactg tacaattcat gagcaccctg
58441 accacagaac gaatttaaag aaagagaaac tcaaaggaag tagatcctca tcgaacatgt
58501 ttaactggtc agagttaggg aaagatgagc ttagcaggta aaaagtgtga gggtggagaa
58561 gcctgatggc tgatgatcaa gcgtcctctg ccactgacac aggtagtgag aagttggctc
58621 tgggagaatg tgacattttt catttgggaa cttgcatagg taagtggcaa tatacatact
58681 cctacacaga tgtgtaacag ctatttatta ctcttgagga tctgccaaca ggaacatttt
58741 gtaaacaatc aaagtacagt ctctcccaag ggcttactct gatggctcca gctatacagg
58801 acacaggctt catgatgcta gttttaatct actggccaat caggaaatgc cacacgagac 58861 tctatgcaga gaaaagctga ctggcattag gaaaagctga acacattttc ttcatccagc
58921 tatggcacta taaaattttg gtcatgtttt tggaatcttt Staattaccg ggaataattc
58981 tcaactacca aaatccaatc cctagtcccc aagaagaaag agaactgtag ctagtggtag
59041 gaattccttt tttgttgact taattataaa tacaatctga agtccagaaa agatagtata
59101 ttagtatttc tggcctcttg ggaaccactt gattctggaa acaaagcagg ttcaattccc
59161 accccatcct caaatcccag tctcttcagg attatatgag atagttatca cacaaaacca
59221 cctgctacta tacacagaga aatacaggca aaagataaat gttgggcttt ggaagaagaa
59281 actgtaaaaa ggtcacagca aagaaggaga gaaagaagat gcggccctgc acgtttgtag
59341 atcgcggtga ttaaagataa actaagaaca taaatctcac atcaaagctg accctcacaa
59401 caaggtgaga gtgtaaagac aggagccagg acacagcatt agctgtctcc ttctgcattg
59461 taagtccagc cagcttggga agaatgttgc ataacagtga atctatatgc aaccttttag
59521 taaatgcaca taactaacaa gctgcatgat tactcaggcc agttattcag gaagggcggg
59581 agcagggcag gattgaaacc accgtaaatg ataaaaacta aactgtatgt ctaaaagtgt
59641 tcttttatct ccaattttgt ggcatcccaa attgtataac atctcaaaat gagactctaa
59701 aataagattc tgtcatcaag aaacactaac attccttcct ccctcaggta gtaatagcct
59761 cttcgtttcc atttcttacc taaatagatt taccttcttg cccacaagca atcccattct
59821 caggatatta ccttactgct gttaatccag aggctgagac taaaggaaac tctcacccat
59881 ttattttctt ggttaatttc cttccaataa caaggtgaat gaataacata ggagggctgg
59941 acacttacag aaagaatcag aacagtgtca cataatggag caatttgttt tttgttgttg
60001 tttgtttttt tttgagacgg agtcttgctc tgttgcccag gctggagtgc agtggcgtga
60061 tcttggctca ctgcaagctc cgcctcccag gttcacgcca ttctcctgcc tcagcctccc
60121 gagtagctgg gactacaggt gcccaccacc acgcccagct aattgtttgt atttttagta
60181 gagacggggt ttcaccatgt taaccaggat ggtctcgatc tcctgacctc gtgatctgcc
60241 tgcctcagcc tcccaaaatt acaggtgtga gccaccgtgc ccggctggag caatttgttt
60301 taacacaaaa ggaatcacac taagtagtcc atgttcaaat tattgccatt acgaagaact
60361 tcgttctttc cccttaaaca tattcattaa gtaaaaagag tttagtgatt acatttcatt
60421 cataagaatt aacaaaataa attcccYaag gcaaagccag ttttctggtt ttcttcaata
60481 aatgtcaatt acttggttta agaacactga ttatctacag ctcacatttt ccttttcgct
60541 aataaagcat aagatgtttt ctatagaaaa aattataaaa attcaaataa gcaaaaaaaa
60601 attcaaaaag caaacacagt ctagaaataa cattatgaca aaattagaat atatctttct
60661 ataacatttt ctgtacatat atacagtatt ttttaggcca ggcgtggtgg ctcatgcctg
60721 taatcccagc actttgggag gccgaggcag gcagatcatg aggtgaagag attgagacca
60781 tcctggctaa catggtgaaa ccccgttgct actaaaaata caaaaaatta gccgggggtg
60841 gtggcaggca cctgtagtcc cagctactca ggaggttgag gcaggagaat ggcgtgaacc
60901 tgggaggcgg agcttgcagt gagccgagat tgcaccactg cactccagcc tgggcgacag
60961 tgcaagactc cgtctcaaac aaaaaaaaaa aaaaaaaaaa aaagagacaa tactatatat
61021 gccctatggt aacttgtttt tccccccaat aattcatagc agtgtttcta ttaatatcct
61081 ttggattctg aatgagatgc aaactagttt caatctcctt aaaaatcatg tgaaaacata
61141 cctggaattt ttcacctttg tgcatctgag ttgatctaaa ttcaggagaa tctataaagg
61201 cacaggggta aatgttatgc agaaaatgtc ctcgatagga gaccttcatt ctgataacag
61261 aaattaatgt taataaaagc aatatttcac aaataccatg ataatcctta aaactgctat
61321 catcttatgc gattttattt tgtagtacag ttttaaaaat tccacagaga tgatggRcat
61381 aactaaaagc acttcttgag gcacaagtat ttcaaaaaat aacgttagaa aaagaaaaaa
61441 acagtgtcca gtattgagcc agaggtatgc tgtctagtgg ttactattgc tcttctaaca
61501 gaagtgacca tataatctgt aactctaRct ggcacacttc tgagagggaa agaggtgtta
61561 ttaataacaa tgccagcaca acagagactg actctctccc caaaaSgctg atattcctag
61621 aagttgtatt tttgtgatat tcaagacaaa ttaactctgg agcatgcata agctttttga
61681 atttcaatgt ctaatttaaa tccactacaa ttttgactca tatttttaat aaaacgtcaa
61741 aaatggttaa aatacttgca attgaaatcc tgacatcaag attcagagca gtacactcaa
61801 cctgggttta acatgttgct ctatagcatt gtaaagtata gttgtagcaa aaaattccac
61861 caacaacaaa ctctgtgact gctttctcca ttcattggca acatttcctc ccattcactt
61921 ccttcccaga ggccatgaaa agattaaagg taaactagga attttgattt ccacagaaca
61981 cttactttcc cttcaagaga atactcagac ggtcatcaac tgaggtttta tcctctgcag
62041 cataagtttg gccctttttc aaggtttgga tcatgcaaaa ctgtccagtt agtcttctga
62101 acaaatctgg aggcacacgg agtggttcaa acaatcgccR gtacatgcca ctgagttcct
62161 tttcaatctt tacctgaaat gcagcaatga ctagatgctt caccaatgca gcagcaatcc
62221 caaaacactg acttctgtgg tctaaatatg gttttgataa ttaacaaatc tttgatatat
62281 accatcaccc ttctgtattt aggccaatag aatcttacac agcaagtgaa atggtgatag
62341 aagtttatac ttcagatgct aaaagggtat ggttaggtca tgtgaggtgg ttcatgcctg
62401 taattctggc actttgggag gctgaggtgg gaggagcact tgagcccaag agtttgagag
62461 Yagcctgggt aacacagtga ggctctatct ctaattaaaa agaaaaaggt caggtgcggt
62521 ggtcacgcct gtaatcccag cactttcagt ggtcacgcct gtaatcccag cactttggaa
62581 ggccgaggcg ggtggatctt ctgaggtcag gagttcgaga ccagcctgac caacatggtg
62641 aaacccccat ctctactaaa agtacaagaa attagctggg cgtggtggca tgcacctgta
62701 atctcagcta ctcaggaggc tgaggctggt gaattgcttg aacccgggag gtggaggttg 62761 cagtgagctg agattgctcc attgcactct agcttgggca acaagagcga aactcggtat
62821 caaaaaaaaa taaaaataaa aataaaaaaa agaaagaaag aaaagaaaag aaagaaaaag
62881 aaaaagaaaa aaaattagta cctatagtcc tgggtacttg ggaggctgag gtgggaggat
62941 tacttgagcc cagaagtttg agactgcagt gaactatgat cgcaccattg cactccagcc
63001 tgggcaacag agtaacactg tctcaaaaaa aaaaaaaatc aaaaaacttt tgcagttaaa
63061 ctgaactcag agcataaggg gaagatccgc actattcatc ataacctctt cctattagct
63121 ataatgcaac tgtttaggtt ttcaatgttg tcacaacatt catcttccca atcttagcac
63181 cttctataaa taacagaaaa ccttttctgt gaaacctttt gtttcacaca cacaaaaaat
63241 ttactaactt ttaaatatgg cagcaagaaa ataaacacaa aataggaatc aatgaggaaa
63301 caaatttaca aaggtaacac atacattaag cattttatct ccatgtaatt acttaatgca
63361 ccaatataga aaaacaaata tgcacagctg caatcactgc ttcacattta tatactctca
63421 agtaaagtga aggaaaaata aaagggtgta aaagagtttt agtgtagaag tttcattgta
63481 agctaaaatg aactctgtaa aatggagaac ccactggcaa ataaggctgg ctactggagg
63541 aagagaaaaa caaaatggct taatcatttc tgttgtcaga ttctccaaag cccaggtcat
63601 gccccatctt tgggcccagc attagtctct ggaagtcata ctaattgggt ggatggaaaa
63661 ccatactgca ctgtatctct ggcaggcact atacgaagcc tatagaccca gatcatgaca
63721 gctgctccaa ccaatgtcac tatagcattt gcagtgctcc tacttgtcct gctgtttcat
63781 tttgaggaaa atccagcatt catatttttc aaaaaagtag atttaYagta tgagaagaaa
63841 caaaagcaca gacactaagc gatttaccta tttggtgcta tgatcatatc agcaacttct
63901 gaaccttaca ttttggggtt ccagcaagtt ctgacattca gaaaatgcaa tcattatcta
63961 cctcctctac tccaaagctc tattaatgag catttaatat gatttattca tgatctgctc
64021 atcccgtaac tctcagatca agcccttttt atgtatttat tttttggaga tggagctcgc
64081 tctgttgcct gtgctggagt gcagtggtgt gatcatagct cactgcagtc tcaaactcct
64141 gggttccagt gatcctcccg agaagctggg actacaggtg tgtgctaccg catccagctg
64201 atttttaaat tttttgtaga gacagggtct atgttgcaca ggctggtctc gaactcctgg
64261 gctcaagaga tcttccaacc taggcctccc aaagtgctgg gattacaggc atgagctatg
64321 gcgcccagcc tcatgaagcc ctcttaattc ttttcctctc tttttttttt ttgagacaaa
64381 agtgttgctc tgtcacccag gctggagtac agtggcacaa tctcggctca ctgcaacctc
64441 cgcctcctgg gttcaagcga ttcttgtgcc tcagcctctg agtagctggg actacaggtg
64501 tgcactacca tgccagctaa tttttgtatt ttttagtaga gacagggttt cgccatgttg
64561 gccagactgg tcttaaactc ctgacctcag atgacccacc cgcctcggct tcccgaagtg
64621 ttgggattac aggcgtgagc cactgcacct tgcctaatac ttttcctctt tgaaagcatt
64681 tactcatcaa aggttttttt gagcacctac tgtgtgccaa taatggttga caggaaaagt
64741 ggatacaaca ataagtgtgt tagattattg tttccaatta ttcactgctc ccaacctctg
64801 taagaggact gtacatcccc ttactccacc ccatgcccca tattatcaaa ctgggccatg
64861 tcacttgttt ttgccaatga aatatgaaca gaaacaatat atgtcccttt tgagcaaaag
64921 ttttaagaga cattgggtgt ttctcttttK ctctccagta ctttttcttc tgccatgaga
64981 atgcatggtc caaatagaac ctgctgcttc agcacagacc cttaaatgaa tgagatgcat
65041 agaatagaat cacagctgac acatagctgc cagagKcaag atacaaggtg ggtgagaaaa
65101 aaagcccatt tgctgttata tatcattgag atttattaca tagcataacc tggaaaaaac
65161 tgaatattac agtaaaacaa cacagactga ctcactatgt ttagatgagg ttacaatcta
65221 gttgaatgcc tattatatat catctgcatc attcaaatta gaatcttcta tgaatcatct
65281 tgttttctga tagttttcta catgcaaatc tggccccaaa cataagatta aggcaagcat
65341 tatatctttt actttactga atgtttgttt gtgcttagga aagtcagtag atatatatgg
65401 ggtgatttct aggacccctg ctgttttcct actctttcta ttcttggtat gatcaacaaa
65461 tacaagataa atcagagttg aaaagaaaaa gttaaagact ggtgttttgg tagcaaccca
65521 ccaaatatgg tgacttcctt agatgaatat tttgggcatt agaaaaatat acagttatta
65581 cactaaaaaa tagcatgaac tatttgtaaa tcattagaat gtttaagaag ttgcctatta
65641 gtaagtaatt ttataactgg gcaatgatat ttccaggtta acatctgaat atcaatataa
65701 aaaatcaagt aatatgactt aaaaaggaaa atattattca tgttctctca tatgctaatg
65761 atttttaaag ttttaaaaac tcatttgtag aacaaatttc gtggtactaa aatgtttcac
65821 tttcaggcat aatgtaaaca gaaagcctaa acttcagaga aattatatta aagtgactaa
65881 atatgctaga tacttaσtct taactctgaa caaagtacct ttcaaagttt tagctttaaa
65941 atcacttcct tattaattaa ttttaataat taccggtctc ttcttgtata aaagatacga
66001 cagatgcaaa atgttgacac ccaagaacac agagttccag atcattatat ccaaggcaca
66061 tcggtagaga gtggcccaga cgatataaag ggtacatcct gttgaagagc aaagttaaca
66121 Ygttagataa tctagaagag cctaagtggg gagcttaata aatttgatat cctctatata
66181 tacagtagtc ctcccttttc tgaaggtgat actttgcaag acccccagtg aacgcctgaa
66241 accatggata gtatacaact ctataaacac tacgttttat tgatctgata cccaagacag
66301 ctaataagca atcactgggt gggtaacaca gatagtgggg ataagttgga caaagggatg
66361 attcacatct caggcaggat atagcaaaac actgcaagat ttcatYgcac tattcagaat
66421 gtcttgcaat ttaaaatgta tgaattgttt attcttggta ttttccattt aatattattg
66481 gactgttgtt gaccacagaa agtgaatcca tggatgtggg gactactgta aatcaaacac
66541 attttagaac tacctaagcc aaatatcatg ttgtttcatt ttgttttttg tccagtgacc
66601 aaaaaaaccc caaatatatg ctttgttgaa taaaatctgt attaaaaata tataggaaat 66661 acaaagttta aaaatatttt taaaggggaa aaatccataa ttctactact ttaagaaagc
66721 cattaaatat caaataattt aattctgcct tacagagttt tcatacagtt ttacctgatg
66781 gcaaacctag cacacataca attttaaaat ctcctttttg acttattcca gtgattttcc
66841 catttcatta aactctttgc cagcatagtt ttaaaagact gcagctgatt aaaccataat
66901 ttatttaacc atccccctac tgccggaaac acaatatttt gagggtataa tttttgacaa
66961 gtggaaaaaa aattttatac atacaaattt ttctgtattt gtgattgttt acttagtctg
67021 gattacctga aggtgaatct agggaatgaa Mtttatagtt ttttacaata ttgaagaatt
67081 gttttccaaa aggtttgtac aaatttgcaa tcctactagt tagaaatgct aatatcaagt
67141 tgtcagtata gtcatgtgtc acttaatgac agggatatat tctgagaaac atttcgttag
67201 atgattttgt tgctgtgtga acatcagaga ctatacgtac ataaacccag atggcatagt
67261 ctactacact atagggtata aaccaataaa gtacagcttg ttactgtatt gaatattgaa
67321 tactgcaggc aattataaca caatggtgaa tatttgtata tctaaatata tctaaacatg
67381 gaaaaggtga acatgtggta ctatattatg ggaccacttt cgttatacga tgcataactg
67441 tattataaaa tgtgaaaact cctaatttga tagtgaggaa ttatgtatac tttattttgc
67501 atttccatga ttactggtga gcctgcatat tttaccaaaa tgttttagcc atctgaattt
67561 tcccttggtg attatccatt tatctctgag aatcttcctg tgttttctta ttgattctct
67621 taccttatat aaaatatccc cagtttcttt tgatcaattt tatgatagga gagttaatac
67681 agtatataca tttaaaataa aactatcatg aagatataaa tcattgacac acgcatactc
67741 acaaaagcta accacccact ttaaaagtta ctcacttgca attttttatt tcataagaat
67801 gatttgatgc acctgaataa agcccaaaat gtaaaaattt aaatattctt taagtaatat
67861 ttcatagcaa atagtgaagc aatttaaaat attttaattt aaaggagaca aggtatataa
67921 tgggaggata gagaaaaact ggaggacctg aattatagtc ctggtttggc cattttttct
67981 ccatcttaat tttggatggg tcattttact tgtctaggtt tcacttttta aaattttttt
68041 ttcttttttg agacagggtc ttgctctgtc gcccaggctg gagtgcaaca gcctcgacat
68101 cccaggctca agccgtcctc ccacctcagt ctcccaaata gctgggacca cagatgcatg
68161 ccaccatgcc tagataattt ttaaatgttt tgtagacaga aggtctcact acattgccca
68221 ggctggtttt gaactcctgg cttcaagaga tactctcact tcagcctctc aaagtgctag
68281 gactacaggc gttagccact atgcctggcc tagatttctc tttctgcatt tacagaataa
68341 agtgttagat ttgataatat ctttggttca ttccacctcc aaaactctgt cttaaaattc
68401 ataattgatg tttgcttttt tatagggtac ggtatttttt tttccattca actccctgtt
68461 cctactgctg taatcctcac cttactcaca ggtcacacag ccacagaggt cccacaagct
68521 tctactaacc ttccagcctc tttttccttg tcatttatca cttttttttt tttttttttg
68581 aggcagagtc tagctctgtc gccaggttgg agtgcagtgg cacaatcttg gctcactgca
68641 acctctgtct ccggggttca agcaattctc ctgcctcagc ctcccgagta gttgggatta
68701 caagtgcctg ccaccatgcc tggctaattt ttgtactttt agtagacaca aggtttcacc
68761 atgttggcca agctggtctc gaactcctga cctcaggtaa tccacccacc tcggcctacc
68821 acagtgctgg gattacaggc gtaagccact gtgtccagcY catttatatt tttaagcaca
68881 atgcactact ctacgttcac cccaatatgc tcaatttcct tctcttctgt gctctttgtt
68941 tggatactat acccatttac tcagataaat cctgctcatc ttccaaaatc caggtcccat
69001 gtcacctcct cagYgggacc ctgctctgcc ttcctactaa gcctatcacc ttctccgtgt
69061 ccccctggat aatgggtgca cacctgcatc ccagcatctg atacgccata ctgggattgc
69121 ccatctgttt ctccaccagc ccccacaaga gtgtctttct caaggatgaa gacggccttc
69181 ctcagtcttt gtctggacac atcacaggtg ctaaaaaatg cacctgaata aatgggccat
69241 cagggaaata atcacataga gaataatttg tcaagaatca ctggctaata taacagattc
69301 aattgtttta atgttctgat gtgaatcaat ttaacttgct tcatcagggt tactgggacc
69361 aaaaaaaatt tgttttattt gaactactgt atctggtaat tgtttttgtt cccaatgttt
69421 ctttactgcc cacagcaaat atcttttcaa gtaataatag ttaaaactat acagtactta
69481 ctatgggcag gcaatattcc aagttaaata tatatatgac acacatttaa ttcacaacaa
69541 ctttgggagg tggtattatt tttaccctta tctgatacat gaggaaactg aggcagtaga
6g601 aagattaaat cacttgccca agttacagtt gacaagaaat agaaccagga tttgaatcac
69661 acaatttggc tttaaagttc atactcttac acatgaatga atgttctggt atctggaaaa
69721 cctaaacaac atatgaaagc acatataaac aaagtaagta agggagagat atggcatgtg
69781 aaggcctatg ctctaagcta attgatatac tgctaattca ttaacaaaga cttacatttt
69841 ttggcttgct atgggcctga caaagaatac tctgaagctc tcaatgtaaa gcccatctta
69901 tgtcagttac agaaaagtta cataaagtat cagttaggta tcttacctag agttaacatt
69961 cccctaagaa atatcatatg aaggtgaaga gtagttggaa taaccaaccc aactgcaaaa
70021 caaatatttg ctacatgaaa aaccagatga tgtatctctc tccagttttc acaagtggtc
70081 ttattggaag gcacaggtat gatactttct aactcaggtg taaaacctat ggcagttgat
70141 tctctcaatg ggctggactc tgtataattc attttgaaaa ttcctgtaaa aacaagtaaa
70201 caaaagtaaa atcgtaaaaa tggcaattgt atctttttac cttcataggt attataccaa
70261 aattatttct gtgaattaaa tagacttctc tagtgcttat gaattagaca gacccagatt
70321 caaatccaac tctgtcacat attaaatgta ttcagttcct tacctgttaa aagatggtaa
70381 taatacctca tttgccttat gatcaaatga aatgaaatac ataaaatact tagcatagtg
70441 caaaactatt ccctcatagg cacatatata cgtataaaca cttgtaggga agggaggagt
70501 gagggaatta gtctttaaga taatcaccaa tgttcataaa ccatggtaat tacaaagtta 70561 tttagtctag tcttccatca aattcccact ggtgactgaa tccaaacaca ggaaaaataa
70621 ctagaaaact aattatttga atacttaaaa aatatgaata ccctcacatc tatttgaagg
70681 cttaggatat ttagaaggct ctatttttat accaccatta aatcactgta tcatacatac
70741 ataatacatt atcatatatg caaataatat atagccatat aaacatttat atataYacag
70801 agagatacaa catgaaactt ttattgtctt atttaaatct ctactttatt tcccataata
70861 attctacctg gtagcatatc acaaatttaa aagtagtaaa cttccagttt acttatacat
70921 atgaaaatcc atagcaagta catttaaaga atatacattt tacacatgct tatataaaac
70981 catttcctat gttacctgtc ttcggtctcc ggtccttaaa aaacactcta ttattaattg
71041 cacaaatttg gtccttgcca aacactatgt aggtttacag attatatgaa ttattctgtt
71101 tcagcaaaat tccaaatggg gaccctaaat acatttaaat ttagaaatat gtatttcttt
71161 caaaataagg tcatgcaatt aatcttactc ttctactgct tgttcttaac atactaaagg
71221 ttttaggtag tagaataatt aattggtaca aaatgggtat tttgaaagga tgttaacaga
71281 caaatgtgaa agaattccac agcttaaaga tgataaaaaa caagcacacc aatttacaaa
71341 ttgtgaatga aatgatcaag tcaactgaag atctttttac ataattctga aatagctcat
71401 aaatattaat agtaatagtt gacttagata ttgatttgct acaaaaagga aagaaacaaa
71461 aattcaccta ttttccaaat gtctgaaatc agcaaatata taagcctatc aggatggcgg
71521 gggggaagat cattatttta ataactccat ttatacaaaa tttgcttttc aaggccaaac
71581 gagaatgaat ctcgtaactt ctgcaggaca gagaatgata tgaggtatcc tctatcactc
71641 ataacccaac atcacctacc ctagcattac ataggttaat aataactatc atttcgacag
71701 cactgtagaa tgtacctaca ctcccattgt cctgtttgtc ctctaggagg cagggacaat
71761 gtttattcat ctatgtactt ccaaggccta gcctctgtag agaaggccac tgagacaggg
71821 atgaaagcca ctctgaagga acgtcaacct gataaacact ttcagaaatc actgttccgt
71881 ctccccagat ctcagtaata aagccagagg agtgcctagc cttcctgagg ttgagtgagg
71941 ttctacacca caagccacca gggtgctaca taagccaggg aaagccactt ctgctcctcg
72001 ggtctgtttc ttccttggaa tagggaaaac tttaatagcc tatggttcta taatacacat
72061 ttacataatc aatcaatcaa tacatgttgc ccctcgagtt cacccaattt cacctgtatt
72121 gcctattaat ccactataat tcaatatcag gcttttacaa gttcttaaag tgacactaaa
72181 agtaccaatt tctggtccaa gaaaaatgac aggaaaacta ctattatgac ccaagaacca
72241 gaaaatatta ttagcagttt ttagaaggta cggtcatcct aaacatgttt tgacgcacga
72301 caccttatta aagagagaga gagaKatata tagatatatg tatctatata tctatataat
72361 tgtctattgt gaaatgccag ttacctattg tcgaaaatat tgatcagatc agtttacttt
72421 gattaccact taatcgttaa gtggcttaca cttaacaatt cttatacaga gaataggtgg
72481 aaagagaaag gttagactgc taaattggta aacttttcag attaattttg actaaatcaa
72541 gagaaattat ttttccctca tcagatcatc aaagttgaag tccttaaatt acctatacta
72601 gtaaagtttt gtttatcgtt tttcaaatag gtgattgtag ggctaaatag ctaaatgctg
72661 aaactaacat taaacctcta ccaaactaaa aaaatgaaaa agataactgc aaacgagcgt
72721 cttgctagtc gagttaattc attctgtaat tctaactgaa tcttcgcaca tctcccgaat
72781 ggcaaatggc attacattgc taagagtctt ttcgcactta ttcatgcttc aaagcaggca
72841 gtttctggga cttgtctggc caacaacccg ttcccaaagg ctcggggaag gaggttgcgg
72901 gtgggtggcg cggacctcgg gtccccagcc atcggcgctc tcccggggcc ctctgacctc
72961 gctccttaaa ggaggagggt ccgtggcaac ggtcctcctc ggccaggcgc tctcgggacg
73021 cgggggtgag gagtgagcgc cgtggcccac cctactctcc gagcggggac ggagtgggcg
73081 acaccgcgcg cccggctgca cgcaggctct gcgcggctcg aggcggccct acagggggcg
73141 aggaggaacc ccggagactc ggcggagaga gcagagacgg agctcaccaa ggggcttgcc
73201 gccgcagagc gcgggagccg gcactcggtg gggccgaggg cccggggacg ctggggctgc
73261 ctgacctgag cggcggccgc tgaccgttga gggtctctgt ggccgcagcg cccagacccg
73321 gggagaaggg cggcctccaa gggccgggag cccctcgagg gcgcggccag cgaggaggga
73381 cagagggcgg cgcccccggc tgcccgggcg cgtMgaacaa gcagctgccg ccagggccga
73441 caaagttgct ccccgagggg ctgagatcca actttcgctt cccgatttag ccaggggagc
73501 gcgaggccgc acacaacccg gcgcgggggg aaagccggct gcagctgcgc ctcccatcct
73561 tacccggctg gtccctggcg gggagcctgg gcagcgccga ccaaagttcg gagcggcagc
73621 ttcggggcgc gggacgcggg gcacacgggc tcagctgctc gacgggagcc cgacgcgcgc
73681 tcctcggcgg gtcggcgggt ccggaagctc cgctgcccgg gccgggtccc caagcccgca
73741 gccgctttga ctaaaatagg catcgcgacg gcggcggcag gcggcggcag ccagggctgg
73801 ggccgcaccg cgcacgcgca tgcgcccgcc gccccgcgcc ccccggcggg cggagcccgg
73861 cgccgcggcc aggatttccc acctcgctcc cgcgactccg ctgcgggtct gcacacccga
73921 ggactcggtt tgaaacgccc gcttatttat tttcttgtcg cctcgctaca agattctatc
73981 cttgtttggg catgagtggg gggcggcagt ctcgtgggac cggcggcatt cgtcgttcct
74041 ccttacgggg ataattcgag aagtgcggtc cgggtaggga gagaaatcag gagagaaaat
74101 gagaaagaga atcctcgttt cccctcaaag ttggacgacc cactcgtata tctccttttt
74161 gggagattcg cccataactc agcacaaaca gggaatagcc cggaaagcgc gcgagttccc
74221 gtccgattgt ggcgggggag gctgaacgtt tggtccacac gggtgcagga cgcgggggtc
74281 aggcctcctg ctgcggagga agagggggaa gaggccgcgc gggagggact tctgacacgc
74341 gccactgttt ttgttttcaa acaggggtac ttaaccgaaa ctagcaatcc caggcggtac
74401 aaggccctcc atcgtaggca aagcactacc tgaatgtaga tttgggccat acgttggaaa 74461 ataagacatg agagtatgct ccgatcaact tttactgttc actggacaac tattttgggt
74521 aagaaaagca aggaaactta ataaagaatt ggcgttgttg ggagttgtct tgtaggacaa
74581 tagaggaagg ttagatgggt acccagtttc caccaaaagt gtcccattat tggttaaaat
74641 tggcatcagt tattagatta tgagatcgtt catgcatgtg aaatgtgatc tcaatataaa
74701 aaataccacc accgattgtg tgaaggtaca ttataaagag tacctggagg tgcacactgg
74761 acaagtctct ggttgaagag atggtgcagc ctagtaagaa agagcatggg ccttgatgtc
74821 acacaagccg ggtttgaata ctccctctcc taccagttta ctgtgtgacc ttggagaagt
74881 tacctagccc ttctgtgcct cagtttcctt tttggaacat ggggataatg atgatgatga
74941 tgatgatgat gatgataatt atgataattg tacctgcact tcatagtata gttttgagga
75001 ctaaatggtg taattatata taagggtctt aaaatggtgt ttgggacata agttctatgt
75061 atatatattg tatttataaa actccttttc taatacgtct gaactttcct ataaccataa
75121 aagattactt tttgagatta cttctttaga gtctgtttct ttctagatgc tctgccagcc
75181 tttttttttt gaggcagagt ttcactcttg ttgcccaagc tggagtgcaa tggcgcgatc
75241 tgggcgcact gcaacctScg ccccccgggt tcaagcgatt cttctgcctc agcctcccca
75301 gtagctggga ttacaggtgt gcccacgtcc ctaccagctg ttttgatagc taccactaaa
75361 tacattttaa ggtgtgggta tacatgtgtg cgtaaagact taactacaca gatgttcact
75421 ggagggtgag ttataataat gaatattgga aatagcctaa attctaacca caggggacta
75481 agtaaattat agaacatcca gacagtcttg tttatgaaag agcatgggcc ttgatgtcac
75541 acaagctggg tttgaatccc ccctctccta ccagtttaaa cagccattaa aaataaaaaa
75601 catagaaaca gactctatgt ttaaacaacc attaaaaata atttctagaa agatattata
75661 gacatcataa taatgtctac taattatata aagcaagcta tgcccccaaa accccagccc
75721 actgcctgtt tttgtatacc catttttaca ttttttatgg ttggaaaaaa tcagaagaag
75781 aatatttcat gatatgtgaa cattatataa aattcaaatt cagtgtccat aaagttttat
75841 tggaacccag tcacgttcat ttttatggct gctttcatgc tgccagtgcg gctttgatta
75901 gttacaagag aaaccttatg gcccacaaag cctaaaatgt ttactctctg gctctacaga
75961 agaagcttac tgatgcctca catagagtat actttgtgtc aggcagtgtt ataagtaact
76021 tagatatatt gtcacctatt acacacccac tccttacctt caggatagga tacctgtaag
76081 gcatgtagat cttataaaga ttgcacattt ttatgaaaag agcactgaat tagttatcat
76141 aagatttgag ttctagcctt tcacagagtc tgtgttttct ttgagtctgt gttctatagg
76201 aagtgaagac tggaaaaaac ctaatcccct cactataacc catctaggat tgaaaccgtt
76261 atttataatg agtatcttac tgtattttaa tttcttatcc cagatgtatg aatagtagct
76321 ttataaaatt caaagcaaga attctaRaca catagcccag gatatgggaa tgccttaagc
76381 tccctggtct cctcctgctg gccacagaaa ggtcagattg aaagcttccg agcgctattt
76441 tgaaagttaa tatgaagcaa ggagctaatt tgcacatacg tgtagaatga aaagggtaag
76501 aagcatgaat aacaaaatac aaggcagtct gtctcctctg taaaaactct ggctagtgtt
76561 agattgacat aattattttt acctttattt ctctataggc atcctagtct acttttacca
76621 gttggataaa accttaatga gacttcaaag ttcagataga ataagttttg tgaaaataaa
76681 acaagatctg agggagtcac ttgttttaaa agtacacata tattgggagg ctgaagtggg
76741 cggatcacct aaggtcagga gttctagcca acatggtgaa accccatttc tactaaaaat
76801 acaaaaatta gcccggtgtg gtggtacatg cctgtaatMc agctactctg gaggctaagg
76861 gacaggaatt gcttgaaccc gggaggcaga ggttgcgatc agccgagatc acaccactgc
76921 actccagcct gggcaataga gtgagactct gtcttaaaca aaaaacaaaa aaacaagtac
76981 tcacataaca gtaagtagcg ttatattcct tatctacaaa tctgcccatg gtatacatca
77041 gtgtagactt tatttcaact gttattacta attgcatgga gactatagca gtttctgata
77101 cattctcata gcagacagtt ctggtcacga ctggtttctg aacccacatt cctctcacta
77161 attgttgcat taactttttc actgaccagt ttgacaacca tcctcactga ttgtttttac
77221 atttcttttg atttttaaaa aattaatgga cttttttaaa gagcagttca agtttacaga
77281 tgactgagca gatagtttcc ctcatgatta acaccttgca ttagtgtggt atgtgtgtca
77341 caaagggaga actcaaaYtg atccatcatt attaacaaag gtctgtagtt tactttacag
77401 ttcactcttc atgttgtaga ttctgcaggt tttgccaaat gtataatgtc atgtatccac
77461 cattacagta tcatacagaa caatctcaat atactgtgct gcagttcttc atccctctgt
77521 ctatcctcct cccacacccc tggcaaccac tgatcttttt actgtcttca tagttttgcc
77581 ttttccaaaa tatcctattg ttggcattat ataatgtatt gccttttcag attggcttct
77641 ttcactaagc agtatgcatt aagtttcttc catgcctttt ctttttttaa tgtgatgtat
77701 gtatatattg tgaaatgatt accacaatca aattagttga cacatccatc acctcagata
77761 gttaccattt ttatgtgtgt agtgagaaca tgtaagatct actctcttag caaattcagt
77821 tRtaaaataa agtatagcta actggagtca ctactccatt cattggatcc ccagagctta
77881 ttcatcttat aactggaagt ttgtaccctt tgaccacctc cccggttttc ccacccttca
77941 gccccKggta actgtattct ctgtttctgt gagttcaact tttttagatt ccatgcataa
78001 gtgaggtcat acaacatttg tctatctctt tctgacttat ttcacttagt gtaagccctg
78061 catttttatt catgttacaa atgaaagaat ttccttcttt tatggctgga taatatttca
78121 ctgtgtacat atgccatatt ttctttatcc attccttcct cagtggacac ttacattgtt
78181 tccctgtctt agctgttgtt aatattgctg caatgaacat gggagtgcag acatctcttt
78241 gagatactga ttttatttcc ttcaatatat acctagaatt gggcttgctg gatcatatgg
78301 taattatatt tttaattttt cagggaacct ccatactgtt ttccgtaatg gctataccag 78361 tgtacactcc caccaacaat gcacaggggc tcctttttct tcatattctg gccaatactt
78421 gttacctctt gtctttttga tagtagccat tctaacaggt gtgaggtgat tatctcattg
78481 tagttttgat ttgcatttcc ttgatgatag taatggtgaa caccttttcg tgtgtctgtt
78541 agccatttgt atgtctttgg aaaaatgtct attgaggtcc tttacctatt atttatttat
78601 ttattgctgt tgagttatat gagtttctta catattttgg atattaaccc cttatcagag
78661 atatggtttt caaatatttt ctcccattcc ataagttgcc ttttcatttt gttgattgtt
78721 tcctttgctg tgcagaagcc tttaagtttg atggaatccc acttgtttgt ttttgctttt
78781 ggtatcatat ccaaaaagtc atggccaaga ccaatgtcaa gaatactttt tcttacattt
78841 tcttctagtg gttttatggt ttcatttaag tctttaatcc attcagagtt aatttttgtg
78901 aatggtataa gataagggtc caataatcag tcttcccaaa acaatttatt aaagatacta
78961 tctttccccc attgtatatt tttggtgctg tcatcaaaaa ttacttgatc ataaacacat
79021 ggactcattt ctgggctatt ctgtttcatt ggtctagacg tgtgatttta tgctggtacc
79081 attgttctga ttactgcagg tttgtaatac agcttgaaat caggaaatgt gatgccccta
79141 gctttgttct tctttctcaa gattgctttg gctatttggg gtttttgttt gtttgtttgt
79201 ttgtttgttt cttttgagat ggagtctcac tgtgttggct aggctggagt gcagtggcac
79261 agtctccgct cactgcaaac tctgcctcca gggttgaagt gattctcctg ccctagcctc
79321 ccaagtagct ggtattacag gtgcccacca ccatgcctgg ctaggttttg tatttttagt
79381 agagacgcgg tttctccacg ttggccaggc tggtctcgaa ctcctgaccg caagtgatcc
79441 acccacctcg gcctcccaaa gtgctggaag ggattacagg cgtgagccac agcgcctggc
79501 ctatttgggg ccttttgtag ttccatgcga attttaggat tttttttcta tttttgtgaa
79561 aaatgccatt ggaattttga tagaaaatgc attgagttta tagattactc ttggtagtat
79621 agacatttta acaatattaa tccttccgaa ccacgaacgt aggacatatt ttcatttatt
79681 tgtgtcttcc tcaatttatt tcatcaatgt tttatacttt tagtgtatag gtctttcatg
79741 ttcttggtta aatgaattgc taaatatttt attgttttga tgctgttgtc aatgagattg
7g801 ctacttcatt tcaggtaggt tgttattcat atacagaaat acaactggtt ttcacatgtt
79861 gatattatat cctttaattt tactgaatgt gcttattagt tctaataatt tttggtggag
79g21 tatacagggt ttttatatat aagatcatgt cttctgcaaa tatacaattt tacttcttcc
7gg81 tatctgattt ggaaggcttt tRtttctttt tctgccccag cgaRgacttt cagtactgtc
80041 ttaaatagaa gacaagacac tctcgtcttg ttcctgactt cagcttttcc tttttctttt
80101 tctttgtttt ttcgagacga ggtcttgctg tattgcccag tctagtatgc agtggcatga
80161 tcatagctca ctgtggcctt gaactctggg ttcaagtaat cctcttctct cagcctcctg
80221 agtaactgca actatagctg tgtgctgcca cagcccgcta attgtcatat ttttttagag
80281 acagRtctca ctgctcactg tgttggccag gctggtctca aactcctggc ctcaagtgat
80341 cttcccacat cagcttccca aagtgttgga attacaggtg tgagccacca tgcccaStca
80401 gctttcagcc ttcaccattg agtatgatgt tagctgtggg cttgtgatat atggccttta
80461 ttgtgttgcg gaacattcct tttgagagtt tttatcatga aaggatgttg aattttgtca
80521 aacgtttttc cacagatact gagatgatca tcatatggtg tttgtatttc actctgtcag
80581 tgtggtgtat catatttatt tatttgtata tgttgaacta tccttgcatc ccagggataa
80641 atcccccttg atcatggtgt gtgaaatctt taatgtgttg ttgaatttag tttgctagta
80701 ttttgtcgag gatttttgca tctatgttca ttgaggatat tggcctgtaa ttttcttttc
80761 ttgtggtgtc cttatctggc tttggtatga gggtaattct gggcccataa aacgtgtttg
80821 gaagtgttct ctcctcttcg gctttctgga agagtttgag aaagactgac gttaaattaa
80881 aagttaaaga ttgaagcttt aaatatttgg tagaactcac tagtgaagcc atttggtcct
80941 ttacttttct cgttgagtct ttttattact attcattctc ctcaccattg ttggtctgtt
81001 cagattttct attacttatg atttagtttt ggtaggttgt ctgtttctag ttgtttattt
81061 atttctttta ggttacccaa ttgtggccat ataattgttc atagtagtgt cttatgatct
81121 tttctatttc tgtggtatca attgtaacct tcatgtcttt ttgagtctta atagcccata
81181 tctttttatt actggatgta ccacggttca tttatccatt taccatttta aggacatctt
81241 ggtttcttcc agttttggca aattatgtct aaacatatat aaacattggt gtggagtttt
81301 ttgtgtacac atattttcaa ctcatttggg taaataccta ggatcatatg gtaagactat
81361 gtttaggttt gtaagaaaac ttccaaactg tcttccaaag tggctgcacc attttgcaat
81421 ctcactagca atgaatgaca gttcctgttg cttcacatct gtactaacat ttaatactat
81481 catttttttg tagggtgggg tggggagttc tagccattct aataggtgtg ttttttactt
81541 tataaattga ttcaattact taatttgttc aaaataacca aacaggttat gcactcaaca
81601 ggtctatatt tttgctagat ggaaaactgg aaacaacatc tcaaagcaaa gggcctaaac
81661 ttttgtatta ttgttttgca agtcccgccg tctaaaaaat gcagtgtcca gatactgtta
81721 atgttaaatt cagggagaag ctccctaaag tcatgtaaca gtttaatcat tggacaataa
81781 actttcacca aaaggcttca cagctcctaa aagaaatgac acacaggctg ggcgtggtag
81841 ctcatgcctg tgaccccagc actttaggag gctgaggcag gccgtttgct tgagcccaaa
81901 agtttgagac cagcttgggt aacatggcaa aaccctatct ctacaaatgg gccatcatgg
81961 cgacttggcg cctgtagtct cagctactcc agaagctgag gcaggaggat cccttgagcc
82021 tgggacgtag aggctgtagt gagctgtgat cacataactg cactccagca agggYgacag
82081 agcaagaccc tgtctcaaaa agcaagcaaa caaacaaaac aaaatttaaa aaacacacac
82141 acggctgggc acRgtggctc acatctgtaa tcccagcact ttgggaggcc gaggcgggtg
82201 gatcacgagg tcaagagatt gagaccatcc tggccaacat ggtgaaaccc tgtctctact 82261 aaaaatacaa aattagttgg gcatgatggc ttatgcctgt agtcccagct actcgggagg
82321 ctgaggcagg agaattgctt gaacctggga gacagaggtt gcagtgagct gagattgcgc 82381 cactgtattc cagcctggcg gcagagcgag actcggtcta aaaaaaaaaa caaaaacaaa 82441 aacccacaca cacaacacca aaattttaaa aagtgacccc gaactttaag aagatagtga 82501 attatgaagg cagttcaaag agtggtagct ttggaattag cagctggatt tgaacaatgg 82561 ttttacattt aataggctgt atgtgtattc agataattat ctcttctgag cctcaattta 82621 cttgtctata aaactgggaa aataactcat agttaccaag atgattttga cttttagaga 82681 ttatgttttt taaaatgcct agcatctagt tcttggtagc ataattgcat atctcttgta 82741 tgcccctaat agtgccctgc acatggttca caattcataa aaattatttg aattctagtt 82801 caattgttta atggaaatga atttgaatca ccaaaattcc ctagtctgaa gaaatagttg 82861 aactatccta tgaacacatg aagtagctaa aatgtagttt catttttcta tatatttgcc 82921 agttttaaat agatggaata cagaatacac aaggtatttt aaatgaaact tgcttataca 82981 ttataagaat ttgatgcatg ctaaaatttc cagtagtttg ggatttccct ggaatagcta 83041 gcagatcaca aggtcaggag aacgagacca tcctggctaa cactgtgaaa ccctgtctct 83101 actaaaaata aaaaaaatta tctgggcgtg gtggcgggca cctgtagtcc cagctgctcg 83161 ggaggctgag gcaggaaaat ggtgtgaact caggaggcgg agcttgcagt gagctgagat 83221 cgtgccactg cacttcagcc tgggcaacag agcgagactc catctcaaaa aaaaaagata
83281 ctggcttcaa aagcaaactc atgaaatatg caacagtcta gattgtataa actgggcagt
83341 tggcagagct aagttacagt aattcaccat cttggggttg gcagaaatgt gcatacagta 83401 actatattgt cagaaaccag aggcctgatc ttccctctgt ctattctttt tcacatagct 83461 tttcttctga aagagaagaa ttacatttgt taatatttgt tttaaatatt aattataaca 83521 aacaaaggcc acagatgaag catttcatag ggtttcctaa tccttttgga aattgtttca 83581 aagagaagga aattattgta agtaagcagg cataacaaaa tcgtgtttta aataaaaaag 83641 gtaagtatga aaagaggatc agagaagtga ccctgaattc cactcaattc tctaagaagc 83701 ttcaacctgt aaccagaagg attcaatctc tgggccagat aggatcttca aaacaaaact 83761 ggatcagggg cctaggtaga taccccaaga agggcagatt caaatgtctg gcgccatcta 83821 tagtgacaac ctctcttgtc ttttgttctt tccctgttgg gaacttctag gaatttgcag 83881 acctataaag cccatctata aatctcaagc atgtccactt tcagagaaga gaaatgctga 83941 caaccattta gtctctgagg acaacacttt taaaggtact Rttttattta gtgtgtaaac 84001 aacttcttta tatgaggtat ttagtggtta gaaaggaaaa cttgttaaag gtagaaaaat 84061 aacttttggc aatttttaat agtatgtaat ttagtggtat agataagatt ttgattgact 84121 gaaagtgaag ctataggctg ggtacagtgg ctcacacctg taatcccagc actttgggag 84181 gccRaggcgg gtggatcacc tgaggtcagg agttcaagac cagcctggcc aacatggtga 84241 aagccagtct ctactaaaaa tacaaaaatt agccaggtgt ggtggcagac gcctatatcc
84301 cagctactca ggaggctgag gcagaagaat tgctgaaccc aggaggcaga ggttgcagtg 84361 agctgagatc ttaccactgc actccaccct gggtgacaaa gcgagactct gtctcaaaaa
84421 aaaaaaaaaa aaaaaagtga agccatgtaa ggacttctaa tctttatctg gtgaaagcag 84481 aactttcaat tatcatagag tttctactat gtgacataga gttctgtatc attttataca 84541 attactcctc caaaaaggct ggtttgggag gcaaatagga ggcctgataa tagccagcca 84601 agtaatttga cataaggcta gaaacaaaaa cccaaagcag cacatcataa agatggaata 84661 ataaaataaa agttgggaat aatgacgctg ccatccggcg ttaattgatg tgcaaaagca 84721 ctcagttccc aggagaaaag aattatttaa atgcaaattt gtattattag tactacttaa 84781 attgttgtaa taaattcatg aaaataagac acctctctag tttaatacat atataaaacc 84841 taataaaata tttatgagcc acatccagca gttttagcat tttgcataaa aaattggtaa 84901 acatgatgaa acatttctct aatccaagat caaacatatt tgatataatt tagaaccaca 84961 caaagtgatt gcaaatgcta tttagtttga aaactatagg gcaccctcac acattcccct 85021 gaaagaacaa aaagatcatg ctttgaaaaa gagattttag agccattgaa tctcttttta 85081 gagtatggRa agaatagaag tactttggac agagcagttt ctgacagaag atgatttggg 85141 tttatacgag atatacagaa ctattatgca gttttactgc atgccacaac acagaatttc 852 OI ttaatatctt tcagccacac taagtcatct gagtagaagt gtatgaatat attataagct 85261 cagaaaatgg catctaaaag caatagaRta ttacagtgtg aatcaggaaa tttttcacgt 85321 tttgaaggtY tcaaatgact tggtttaata aataaataaa acttgtaata cctagaaaat 85381 tgatgttgaa tgggaaaaat aaaatattgc tattaatgac ttggcattca gtacttacat 85441 tattgatgac ttaacatgct ggcatgtgat tcccagctgt tttaaggtga cgctacagat 85501 gtgtgattcc ctagagccat ttttctctat ctctgttatg gcctttatta cttgctacct 85561 tttacatatt tatgtaaaag Wctttttctc cctccaggtc aaaagtttct ggaggataag 85621 aagtgtatct gatttatctt tYgtatctcc gtggtgctta gcacatgatt tacatatatt 85681 tggaactcgg taaattctcc aatagaacaa acagtaaatc tttttaaaaa tcatgtttta 85741 caacttaaat tattatgaat ggggaaaaca gtagaagaaa tgtataccaa tatgttaata 85801 gaaattgggt taggatagtg gaatgattgt cttttctttt ttctattcta acttgtttat 85861 aatacattat ttttctaata gaataaataa caaagtgaca cttaatattc taccaggtca 85921 tattacttta ttagaattat ggtgacgtct caccatgaca gtgacacccc accccacagc 85981 ccaccctcat actccccatc accagcgtcc tctcctcccc tgtcctgtct agctgattaa 86041 tgatggaaca ggaacaactt gaaaaagata cgtttggaag gagtggaaag agctggtgga 86101 gcagagggaa ggtttaacca tgagattcat tcagaattca ttcattcatt cagaaacact 86161 gagtggtctg ataggtggga aatgcttggg gtcagaccgt agcaataggg gaagaatgca
86221 gaggcctcca agtcagaggc agcagcagag ccaaccacac tctaggtgcc atcagcccag
86281 atacccagag accaactacc caagcaacat tgcattcgat ccagggagga attaggagtt
86341 caagatcacc ctgggcaaca tagcgagacc cccatctctt aaaaaaatat tagctgggtg
86401 tagtggcgca taccatggta gttgcagcta ctRgggaggc tgaggtggga gggtctcttg
86461 agcctgggag ttctaggctg cagtgagccg ggtcgtgcca ctgcactcca gcctgggtga
86521 tggagtgaga cctcattgca aaaataaata caatttaaaa aataaaatat aataactgcc
86581 taaaatggaa agaaacatct ttttaaaaca tttaaaaatt gttatgggta cataatagtt
86641 gtatatattt atggggtaca tgtgacgttt tgatacaggc atacaatgtg taatgatcaa
86701 gtcagggtaa ttggagtacc tgtcacctca agcatttatc atttttttgt attgggaaca
86761 ttataattcc actcttttgg ttattaaaaa tatgcaataa tttattgtta actatagtca
86821 ccctatttat tgtgctactg aatactagat cttattcatt ctatctaatt gtatttttgt
86881 atccattaat gattccactt catRtcccct ttaccgacta cccttctcag tatctagtat
86941 ccatcattct actttatatt tccatgaatt cagttttttt ttcagctccc acaaatgagt
87001 gagaacatgc aatatttgtc tctctgtacc tggcttattt cacttaaaat attgtcctcc
87061 agtttcatcc atgtcgttgc aaatgacagt atttcattat tttctgtggc tgaaaatttt
87121 gtctatatac cacattttct ttatccattc atctgttgat ggacacttat gttgattcca
87181 tatcttcgct attgtgaata gtgctgcagt aaacatggga gagcagattc tcttcgatat
87241 actgatttcc tttcttctgg acgtataccc agcagtggga ttgctggatc atatgttact
87301 tctattttta attttttgtg gaactaccat actgttctcc atagtggctg tactaatttg
87361 cattcccacc aacctttctc cacatcctca ccagcatctg ttattccctg ccttttttgt
87421 aaaggccatt ttaactgggg tgagatgata cctcattgta gttttgagct gcatttttct
87481 gatgattagt ggtgttgact attttttcat atacctgcca gccatttatt tgcatgtctt
87541 cttttgagaa atgtctattc agatcttttg ctcgttttta aattggattg atttttttcc
87601 tattgagttg cttaagttcc ttatatattc tggttattaa tcccttgtca gatgaatagt
87661 ttgcaaatat tttcttccat tctgtgggtt gtagaaatgt ctcttaaatg gcaggatcaa
87721 atgtttgttt tctgccatcc ctgggaaaag ggtgtgagag ccatattatt taatttatca
87781 tttaaaatgg aattatagtc atccttgggt attgtggggg attggttcta ggaccccctc
87841 agataccaaa atctgaggat gctcaagtcc ttgatataaa atggcctagt atttgcatat
87901 agcatacaaa catccttcca tatactttaa accatctcta gattacttat aatacctaat
87961 acaatggaaa ttctatgtaa atagttatac catattgttt ttatttgtat tatttgtagt
88021 gttgtattgt tattttaaat tttttccaaa ttattatttc caagaaatag taattctaca
88081 tcatgcagga aaaaaaatgc tattattaca ggccttacat tttattttgg atccaaggtt
88141 ggttgaatct gtggctgtgg aaccctcaca tacagggggc tgactgcact tatgagggac
88201 atgataatcc attacatgtt tctgttaaaa aagaaaattt aattgggagg ccattaggct
88261 gaggtggctc cagtgccttg ggctcctatg taaaaaaacc aaagcccagt gtaaacagta
88321 aaacaaaact taagcttaac caatcagaaa ttgccaacca gcctctaact agggactttc
88381 cacactaacc Rctgaagtat attttctttg tcttgcttct ggaccttata agtttctctc
88441 ttgcctgtcc ccctacagtg aagctctgaa ccacttgtag cctagtgctg cctgattcat
88501 gaattgctgt ctgcccaaat aaactcttca aaattttgtt ttgcctaagt ttacctttta
88561 acattcccaa caaagaatct ctaagcaaaa atcattttgt agattttcaa ttcaataaat
88621 gatcttggaa cctaaagact aataactgtg catcctgaac aagtgctgtt cagactcact
88681 tcaacagtat cagcaagaaa aaatgtgact ttgaaagtca tttaaggaaa taataattct
88741 atatcataaa aaaatgctat tattatagtt cttacatttt atttcatgag aaactactag
88801 tggcactgca taattgaaat caacttgaga agggaattca atgttaaaat tcaaatacaa
88861 aaatagatgc aattggctgg gcatggcagc tcacgcctgt aatcccagca cctggggagg
88921 ctgaggtggg aagattgctt gagcctagga ggcagaggtt gtagtgagcc aagatggcac
88981 cactgtactc tagcctgggt gacagagtga gactctgtct caaaaataaa gatgcaatta
89041 aYttccttct atgcaatgaa tatttacaaa gcagctacca tgtgccaggc attgttctct
89101 aacagtgaag aagatataga ctagtggaag agtttcagag tagaattcct tttctcataa
89161 gatggacatt gtgcttgtgc attggttaaa cttttatctc aaaggaacca acttatattc
89221 tgcagtaata tcctgttctt cagaaacccc acttgtatta caccaaaaat ttcttccaca
89281 tcttggaacc cttacctggt gctatttgaa aaaacttcag cttttacaac gtttcattgt
89341 acataaagtt ttattctacc tgagagaaga aagagaagta gcactacaag gggcactgaa
89401 ttaattttct tataagaagg agtggatggc acataaaaca tgatgggctg agataatgaa
89461 ggcttctctc taggatacct agagagagac ctcaattgag ctgtgataat atctgaatga
89521 aattggacag aaccaaaact ttaaaaactg atttaaactg catcaaagaa acttggcctt
89581 gttctttcat tatgtaaact tatagccatt taaaatagag ttacacttaa tgacacattt
89641 tacttgtaaa ccacatttga gctcaagcta ctgctgatga ttcaaaagaa gaaaggttca
89701 tgtttgaata atttttcctc atgctgtcac taacagattt ggaagatgtg taactagcat
8g761 tttggcattg aattttcctt caagtcagac tggggacatt ttagtactct ccaagtcagg
89821 aacacagtca agaacatggt cagtgcagca tgaaaaatgc aaggacactg atttagaaga
89881 attaggctta agctgagtgt caccactgtt tactaactgt gattcagtct ttctgatttt
89941 tatccataaa atgggatcct tccaaggaac aagcaaatga aatcacatgt aggcatgtgc
90001 ttcataaact atgaagtgtt aaataaatgt aagacattgt tttgtaatta tataatttgt 90061 gaggtaaatt tacatttaat aagagtagta atctcaattc tgatggcctg agacacttga
90121 tattatatca agtggagcta aaattctatg aaattatgta aaaacaaata ttttagaatc
90181 ttataaataa aataaaatta ctcttattaa gatcactaaa gcttgaattg gaataaaaga
90241 aaaaagggga caattacagt tcaagacaca aattatcagt tcttagggag aaaagtgttt
90301 taaagttccc tgccaatctt taatagctag taggttttaa aactagtcaa atttagcata
90361 gcaataaaac ttgaagttat gttcaaatca tgctgatatt atatgcaaat gtacaattca
90421 gcattacagt catggtaata cttacgatga gatgactaag agttaaagta accagtgttt
90481 cagtcttgct gcatcttttc acagctgtga gagttccggt cttgaaataa tacacagttc
90541 tatcaaatta aacctgcatt ttattataat aggtctatat catactaatg cttatttgta
90601 tttttgattg atatgtatgc gttaaatttt agtagaatga agaaaaacag tggaattaat
90661 tggacccatt gatctcttta acttgtataa aaactgtctt ttactaacaa gtaatactaa
90721 attggcacat catttctgaa gtttaatttc tctaacaatg tgcagtatag gaagaacatg
90781 gaacccgatt agaaagtgcc atccaatgct gcatgtatat ttatggcKtt tgtcaaacca
90841 agcatctcac atacataaaa ttgtaaacgt attgctttta caataatatg tactgtctgc
90901 ctagtttgtt tttcttatgg ctcttgtcag ctgaggaaat ttcactttgt aactgccctg
90961 ttaattctgc ctttctgggt ctgagcagtg taacaatgtg gcatccagag cttatccaga
91021 tgagcggaga gcaaatgaat ttccttctgc tcccctgttg aagaggagag aaaaattctt
91081 caagctgtaa gtgctcagag agcatcatac tattctttac agtagactaa tctcaagacc
91141 atgagttcct aggggctgca gagtccaagg caaatcccac tgatcctttc tcatatttgc
91201 acaggggtca aatcaagttc agaggaatag ccccatgggg atgggaagcc tccagatatg
91261 caggtaaagg aaaggccatg caagagagaa gcctgcagcc tccagggact tgctttggcg
91321 actggggtgt ggggtgttta cggcctcatt ttgtgccaaa gccactctct tttcccggac
91381 tcactact tc tcagagtccc tcctgaccat gaaaattagg acagaaaatc acaaggcagt
91441 caccccaatt tcttaaagtc taggaacaac tcagctaggg ccagcttcct gggcatgcga
91501 cctgtgcagt cacaaagggc tccaggctta caagagcccc gcacttggca taatgctctg
91561 ccatctccat cttgaaattc ttaagactct ttgaacaaag agtccattta tttatgaata
91621 tccagatctt gtatacaaag ccataaagca tttttagcac aagaacacaa gctgttgctc
91681 atcttagtgc actcttatca atgacaagag aaccaaagga tggaaataat taggctaaga
91741 ctaaaatgag cccaattttt aataaaaatt aaattttagg ggcactatga tacagaggtc
91801 agaggtattt ttctaggata tgtgtcattt ctgctttcca tctggtttga ttattttgag
91861 atagtatgtg gtttgctaga catttcaaac cagacataca atacagctac ctaaaagtca
91921 ctgtaggttt ttgatttttt tttttaataa agtgagaaaa cctgagtgca aacctaggta
91981 ttggataata gcatatctgt taacaccaag gaacagtgcc agccctatac agaagtgaag
92041 actgtgaagt ttcaaagcat ccctttacct cctctttcag tatcccttta tcccattatg
92101 tttgtacccc tttctcctta tagtaaaaat agatttctgg gaaacttaca tataaaatct
92161 tgtcccctct gccactgagt tgagccaaaa gtctacatcc catttctatg tggctttgtt
92221 ctctgctgac tttaatggtt agaaagctat ctgataatta atccctgtaa aattattacc
92281 tggtagtact aacttaagat gtgacttcta cctgggatgc tctgcatttt aatactttat
92341 aaatatctca aagtcttaaa gattcaagaa atgaatttct cccagagcca ttgtaaagcc
92401 cactgacaag ccagtgggtg cttcctgaag gcctttgatt gcatctggca gacagctgcc
92461 ttcgtgtctg cttggaagag ctgcccatga tggcaatgtg tggccaagaa atagaagaaa
92521 ccattccagt gattccttta gttcatgcta aacttgaata gctcagtagt tcatccagac
92581 taatgatt ta catcttgtca cattgtccca cttatggtag atgctaacat acaggaaaag
92641 caacgtcctt tacataaccc cagtacttcc tctccYgttc tccttgctga ctttgcttcc
92701 taggtcaccg agaaaatgaa aatcactgga gaactttcac aatctctcac cacatctccc
92761 acttgccagc aactactctc acagatactc ttctcttttc attcatgaag aattgtccat
92821 atttctcttt aaggccactg gatcccatca cctgctcaag gtcatcactc ccgcagttca
92881 Ytcctcactt atggattatt tccatctgca tgcaaatgca ccatcttatc tgaaaatcaa
92941 taacaacccc ctctcttgac cccactttct gcccaggcta ctgatcattt ctatttcagt
93001 tcacatcaaa actccttgaa aaacttacct acccttactg ttccaacttc ttgcctctca
93061 ttctccttca acctgcttca gtcgagtttt tgttcctgct cactccacca aaactgctct
93121 tgttaagttc cccagtgact tccatgttgc ttaacccgat ggttcattct caggcctctc
93181 agccacatct gagacagttc atcactccct tctcccagaa attctctttg cttggcttcc g3241 aggatcccag gctctcctga ttttctttct acctcattgg ctgctcttcc tcagatcctt
93301 tgctgattct tcccccatcg ctttgtcccc ttaacaatgg agtgctccaa ggtaagcctc
93361 agaccatttt tcttctgaat ctacactcac tcttttggcc atctcatgga gactcatggc
93421 tttaaatacc atgtatatgc taaatactcc caaagctgtc tctacagcgc agacttttct
93481 ttgaaactcc aggctcatat ctccagctgt ctactctact tcagcgtcta gcaggcatct
93541 cactcttaat cctcatttta ctttccaagt ccactctttt ctctcttccc cctagtctat
93601 tctcagcagg ctagccagag tgatcctatt aaaccatggg gcagatcata tcactcttct
93661 acttcagacc ctacaatggc ttctggtcac tcttagaaaa aaatcaaagt ccttaccatg
93721 acttatttag gccttaccca gtctgcccac ggttactttc tgttcattct gtgccagcca
93781 aactagcctt ccagctgctc ctggaacagg ccagtcatgt tcatgcctaa gggcctgctc
93841 agttgctgtc ccctttgccc aaattgctct tccctcagat atctgcatgg attcttccat
93901 tgcctctttc aggtcttcat tcagacattc ctttttgtgg atactttcct tgaccaccct 93961 attaaaattg caatgccctt tcttacccac cttctctaat ttatcactcc ccttggtact
94021 atcaccttct aaacatttac tgatttactt tattatgtct cccgcatccc cagaatgtaa
94081 gctttatgag gggtgggatc tccatctgtt acctgatgta tccccatgcc catgtcagcc
94141 atagaaggtg ctcaatacac acttgttaaa tatttgataa tgtatctctg tatcaaagaa
94201 catagtctgc atgtgatctt cagaaaMcca gttttccaaa ggaagggatc agatctccaa
94261 ctagggttct ttcttaagct cttcacaaag ctgaagcact cgctgtgagg cagacccttg
94321 tgtttgtgcg gtgggctgag cattccctgt gaaccctcgc tgcccattca caccactgaa
94381 agctctttct gctgaacacg tgaaactgaa acaccgtgca acatttttac tattggttca
94441 ggagtactct tttgacttag taatgatcag gcagctttgt tttccaggaa atgcttcttt
94501 ttaaatgtta ttttatttgt agcaataaaa taggcttcaa gattcacata ttattatctc
94561 ttgcatttat tctacttttt agtcRcatca agtaactgca catttaaaat aaataNttgc
94621 tttcactgga ggttgtagca aaaaagtgaa ttccggaaat gcctatgtgg acagtagcaa
94681 cccaccctca ggctgagaat acttgctggc tStttcttga gaagcaactc ctgagtcYat
94741 agggcaagac aatgcatttg agtaaatgtg agaaaagaat tgagaaagtg gaatttcatt
94801 ctcccagttt tgatgcagaa aagggcaaac tgcccatagt tatccacccc ctccccaatt
94861 ataacaatga gaaatacaag aaaaatttgt aaagtttatt cacaatgcag ttgttgaaag
94921 gaataaaaca gttggcaatg gcatctcgct tctgaatttg atttataaaa acattaggga
94981 gctctttttt tgtattttgc tatttcactg gggaatgatg aagagagagt ctttttttat
95041 acttataaat ttcagacttt gatgtcattt atcacagtat cgtctggaat tctgaaaatg
95101 ttgtgtcagg ggtgatctgc gtatttctgg agttgacatt tgatagaagt tgggtagccg
95161 aatatcatag tgatatcttt ttcctatata taccctgtca ttcaaggcat agagtttatc
95221 tgcaatgtca ctgccaatta gcactgaaaa aaNgcgggag atgtagcgat gctgagcaaa g5281 gagcagatat aatttctttc tcctccaaga cacatatcga caatcagttt ctgcagtgag
95341 ggttacctaa aaaacacaag accacacata aacagatgtg gaagcaagaa aacttctgcc
95401 acatttttag taccccaatt gttaaattaa tttcacgtgc tgcctttttt ttaggttgaa
95461 aaagcccact gacctacaat atattgcaaa aatagaaact acaaaattcg ttactacata
95521 cRtaatttat aatatgaata atcacaatgt tctagccatc ttcaatctgt ctgtttttct
95581 aagttccagt atctacattt cttttattga agggagaact acttgatctt aaaaaaaaaa
95641 aaagttggct gatgttacag aaatatttcc aagtcacttc tgaagactgt ggacatttaa
95701 ccctaatgca gtttctgcag tagaaaacag aatttatata cctaatttgc atacatattt
95761 gagtttgttg catacacaca tatatttgtt agaaaactgt gtaacaaaat aaatgaaacc
95821 tgctgaaatg attatctttc aaaactgcca gacgtggcag cagagtaaKg acagtaagtt
95881 tagcattctg ttgctgtaaa acaactgaaa tccactggca ttttaaattt taaaaatcat g5 4i ttatttttta gtaagtgcag ttttttgttc ttgatgtttt ctagacgtcg cattagcagt geooi gtttagtcaa atctcaatta tattttaatt cctaaatacg cagttatgca aagtaaagct
96061 taaagtattg atcacagcct ccttcctgtc atatgtagca cctgttcttc tcatcgctgg
96121 acctataaag tggcattaat catcaagagt ccagcagaat tgggaaagtc atgtatgctg
96181 caaagtacat tccaaagtct taaaatattc ttgtcttatc cactgttgtt tatttgttta
96241 cttattttta aacaaacatc tgtttgaaag agggagtgct aactgtgtgt tctggtatcc
96301 cttacctgaa aaatgccttc ctctgtgggt ctcagtgaat cccactcagg agaatccagg
96361 aactgaaggg ggaaaatgta atgcagaaat tcgccatcaa ctgtcactct gatcctatca
96421 aaacacaaga acaacattta taagggaagg agaaagagag cacataattg gggaggggtg
96481 gggggtagag gaagtgtatt tcagatccct gatgactctt gccctttatg attttgaaag
96541 gcaaaatatt aaattcatac attataataa gtgacataat gtcctgtaag attcatgtta
96601 tcatgttcct tatacagtca ggattctgga atattgagtg aaattcatca gaaaattcat
96661 caagttgtac atttatatat gtccatttat gtgtgcatat tatacttcaa taaaacattt
96721 taatggactt tgtcagattt taaattaagt agggaaacat ttaagaacat agaggagttc
96781 tgcaaatacc tctgtaaacc aaatttttat tttttattta ttttttgaca gagtctcact
96841 ctgtcgccca gcgtggagtg cagtggcaca atctgggctc cctgcaacct cctcctccca
96901 ggttcaagcg attcttgtgc ctcagcctcc tgagtagctg ggattacaag cgtgcactac
96g61 gatgtccagc taagtttttt gtatttttag tagagacagg gtttcaacat gttggccagg
97021 ctggtctcga actcctgacc tcaagtgacc cactagcctc ggcctcccaa agtgctggga
97081 ttacaggcgt gagccaccgc gcctggcctg taagccacat ttttaacttt ttgaaaacca
97141 tgagtaatcc cattattgtt tcctctccca aactttgttt tcaaagttta ttttatttta
97201 tttttgagat agagtctcgt tctgttgctt aggctgaagt gtagtggcgc gatctcagct
97261 cactgcaacc tccgcctccc acgctcaagc agttctcctg cctcagcctc ccgagtagct g7321 gggactactg gcatgtgcca ccatgcctgg ataattttgt ttttctattt tttcagtaca
97381 gatgggagtt tcacagtgtt ggccaggctg gtcttgaact gctgacctca ggtgattatc
97441 ctgcctcagc ctccaaaagt gctgggatta caggtgtttt tgggattaca ggtgttagcc
97501 accgcacctg gcctgttttc aaagtttaga tttctatata tgttcctgaa gtgtctcccc
97561 agcctgcttc tcatgggcaa ttgctagaat ttactgaaga aaaaaagata ataataaaat
97621 ttaaatgttt tctgttactt aaaagaaagc cctatcaaag agtctttaaa atattttgca
97681 cgccaatata agtattctat taattcaagc tgacatcatc ctcttctcga ctttcagtaa
97741 ttaggaaaca aatatcatat cacataaaca aattcatact ttatgtaatt tgatttctaa
97801 gatgaaatat taaggctctt gattattttc tgcttcaagt aaataatgcc atataYtcta 97861 aatggctatg tctgtgactc aagtatcaaa gacttcctca agcctcaggg tgctaaatgc
97921 cacccaggac tatgtgatac tgagatggaa aaatatagtg gaaagaaaca caaacaacta
97981 atacttgagg aaagacatgc aagcaccaaa ggtacaaacc ttcctgaaac aagcaaggag
98041 agtttatcaa tggaagtttt cccctgcatg gcataacagt gttccttttc caaagtaacc
TM7SF3 genomic sequence (SEQ ID NO: 8)
>12: 27004551-27096350
1 acccaaatac taattttcat gttatttttg aacagatgcc tttttggaaa tcttaaaaaa
61 gcaaacattt caaacagttg gctaacacgc atgaactaac actcattcag tttttaaatt
121 acggatgata tccgtattaa cattataatg actctatact acagattgac atggtacatc
181 gtaacaagtc cgaaggattc ttccttgatg catctcgaca catccttgaM Scacctcaac
241 atggactgga gagaaggcac ttggaagcaa atcagaatgt acactaaata aacagtcaac
301 ttttggggtg tggatggaag gggggtccat tttaaaagtg cttttacatt gaatttccct
361 cccagattag atcagcaaat aaatgaaatt tattaaaaga atgttgtgtc tttaatagcc
421 atgctgttca gtgtagaaac tttaaatctc tcattaattt tctgtgtatt gtatcatgta
481 cagcctgtta gatatttgca ggttttatag gttattcagt ccaacgcttt atttatttgc
541 tcttgttagt tgttgctgtg aaacagtcat ttcctttctg gacatcaaag atattttctt
601 ggcattaatt ttaaactgat ttcataaggt caaagtatta aatgttttaa ttcagattgt
661 ggatagtttg tagtcctttg attttgcaaa tgaaattaaa atgcctttgt ttagatgtta
721 ggattaagta tagtagtgct ctctccattg tgtcttaatt tttttttaac tcacttgtgg
781 caggtcttta ttgaataaag gaggaataaa cctagacagg gagttagaaa tgaaagacat
841 ttcaagacag ttcaagggtt atgttggtga cacttcttgt cttccagaca gttttgaaag
901 cacagatctt gcctcttgtg cttgttaaaa aatctgtgat acttctctga agattttata
961 attaaataag tgaaccatta ccatgacctt ttataaaagt gctgccctat ttgaagtatt
1021 gggttttttc tcatgatgag ctttgttaga cttggtactg aaaaaatcag tagttttttt
1081 ccttctattt taaaggcaaa gaaatgcttg cttcagctag gcatggtggc tcatgcctgt
1141 aattgggagg ctgaggtggg tggatcacct gacgtcagga attggagacc agcctggcca
1201 acatggtgaa accccatctc tactaaaaat acaaaaagtt agccaggcgt gatagcgggt
1261 gcctgtaatc ccagctgctc gggaggctaa agcaagagaa ttgtttgaac ctgggagtgg
1321 gaggttgcag tgagccgagg tcgtgccatt gcactccagc ctggccaaca agagcgagac
1381 tctgtctaaa aaaaaagaaa tgcttgcttt ctgtgtagtt ttttaactta ggtcagtgcc
1441 ataggactga ccaaatcata aattgaggat gctgttggta ttcaaagttt ttactcatta
1501 cccttactca gtttgcagct gcaatgatct gtacttaacc tgcttttaca tattatgctt
1561 ccttgacaat gggaggaatt ttaatggtta acttgcagaa tatgacagat acttgtctta
1621 atatcattct tcctaccata atctaattca aaactatcca gtagaacttt ctgaaatgat
1681 tggaatgttt tttatctgtg ctgtccagtg tggaagccag tagccacatg tggctgttga
1741 gcacttgcag tgtcactaat gcgtttgagg gactgaattg ttaattttta aaaatgtatt
1801 gattttaatt aagtttaaca ttgttttgga cagcacagat tagcctttta gagtaccttc
1861 ttgctgagta ctagcagtgt ataggtttcc ccatgaaaag gacctacatt tttgttggtt
1921 aagaggttat taaatgtgct ttgccaaaga tactaccttg tcatttcttc cagcttatta
1981 gttccgtggg tttcttggag tactgttaaa tcctttttac aaatatatat atacacaact
2041 actgaagaga ctgtttattt ggggagttat tcacttttat atttaagtct taggcttaat
2101 atgataaaat acctctcagt tgctgtgaat aatggtctat agaagctgtt cattgagaaa
2161 atgattattc tcgagtttct gttgatttta aacctttttt gtctgtctct ttcactagac
2221 tgtaagcttc ttcagatcag gggacatgtc ttgacagtct ttgtattcct gttgtttagc
2281 atagtactgg cacatcatag gtgtgcaaga taagaaaatg agattggaag aatttatgct
2341 acttgctgcg cctaacaaat gtggatgtct gtattatact gatactatat tttcaatagt
2401 tagcaaagaa ggccatttaa tattttaata ctgaaaagca gaattgtgct cattttattc
2461 aatacttacc atataccata cactagatag taggtggatg taaagatgca gttcctgctc
2521 tcaaagagga ttatgaccta gaaaaggtta cagattggat tgagataact ttataggcct
2581 gaacaataca gaaaagattt ctaaatcatt gaagacttca gggaggaaaa gagattgaat
2641 gcgtcggcaa tttttatcat tcccgttact ttgaacaata gtgtatgtaa gtgcaaaaaa
2701 aaagaaaaag ttgctgatca ttgtggtgag aggaatgtaa aatatgagta tttttcttgc
2761 tgctaggttt agttatattg tgctgcttat tcttaattct agtcctaaca aatttgattt
2821 caaaagcaca tctgtggtca accaacttca ttgttaatat ttgttttatt catattaagt
2881 gacaatgtaa gaatattcat gttaagtggt actgcagatt ttataaaaag gagaggatcc
2941 aaaaataaaa aagtattttg ctgatttcca actcccatcc ctctttttca ggaactgcaa
3001 gcacatgttg accagataac tgaaatggca gcagtaatga ggaaagccat tgaaattgac
3061 gagcaacagg gttgcaagga acaagaacga atatttcaac ttgaagtaag ttttacattg
3121 caaatgtaga tgaaaactgt ccatataaag atttatgcca gaaaatatat cccattttta
3181 aatatatatt tactcttctt gggtactggt aatgttctcc tggatgctgt ctatgtgggc
3241 atattatgca agaccattta tgtggtgatg caagaatcta ggattattag taacttacaa
3301 tataccagta atgtagaaaa ttgatgtttc attctatatt gcttatctta tgaagtgaat
3361 gtacttcttc aattgagtca tttttaaaat tttgtttatt ctattagaga tcatagtgat 3421 acagggaaat tttttttaat ccacaaatat ttaggggcac tcttattttt ctggggattc
3481 taaaaacctt tgtcatctgt cctttatttt atgacagtga aagtaccagt ctctgaataa
3541 ctgaaatcag tacaatagac ttttatgcct taagagcttc attttgaaat cacggcgggg
3601 aacctgcttt agactactaa aatttagaaa gtgagactga agataaagtg atagagaaca
3661 aattatgaaa ggttattgtt aaatgtctac aaattttttt acagtaacta accaaaagga
3721 ggccagaaag caaagttatt taccagtgcc agatttggtc acttactttc cttcttgaaa
3781 aatatcatca gctaccccta ccctgctgct ctcaaatgcc aatgagctaa acttgtccta
3841 cattccatgc tatcatggaa agtaataaaa atactaaaaa ttactaggag attctagcct
3901 attcactggc tttacgagtt tatataaaaa taaatctaga tgttattttc ttcatctcta
3961 atgtgattgt aaaataaggc aatttctgag cttctgttta caattatagc tgcttaagta
4021 agaaggcttt gcagtggtgg aagatgttga acacgattcc tagctgcata agtgttcttt
4081 agattcaagt tgccaactgc atatatcatt gagtagatta atgccaatta cagaccttgc
4141 ttgtttgtta taccttcata tgttcagt t ttcctaacat atgtttgtga tgttgtagct
4201 accttgtaga tagtgactgc atctttgttt ttgcttgcct tttagcaaga aaacaaaggc
4261 ttgagagaga tccttcaaat aactcgagaa tcatttttga acctaaggaa agatgatgcg
4321 tcggaaagta cttctttgtc agcattagtg accaacagtg atttgagtct gaggaagagc
4381 tgaagagttt ctgagtctgt gagcttctta catggctcca aatggtcaaa taagtgaatg
4441 aatgaatgga cagaaaattc aatcctttat ttttttctct gtaaatatgt acagtgcacg
4501 ggctatgaga tagcaacaaa aaatgcatag ttaatggtca tagactttat tccaaaacat
4561 aattggaaaa tagaaactga gccattgcca aatggtaaag aaatgaaaag ttttcacagt
4621 gactactgaa tataccaaga gcttttggca gtactgctgg ctttctgggt gattaattag
4681 gtaaacttga atattcccag taaatgtttg agaatgcata aaattatacc aatttaaaaa
4741 tataaatttt tgccactgtt ttgtgaacgg aggatttgta cgctaaattt catccttatt
4801 tggcgtcaaa gttgatgcaa agtttatgta ccatgagact tctagtgatt gcctactttc
4861 acatttattt aaatttttgt gaaagaaaat acagttttaa aggctatagg aatgtgttat
4921 atgtacctta aacagataat ttaattttag caatttatca taactgatac ttagctaaca
4 81 attgtccata acttgtttaa gtgtaagaaa taccatttca ggaatgaaaa agaaggaata
5041 ctactttcta agaaagaaga tcttataata gacatattta gtaggttaaa ctactccttt
5101 gaaagaataa gttttggttc aaagtcaa a atgaagacga gatttgtttt tctcttctct
5161 ggctgatttt taaggatatt atgtagttca tttagttaac agaattgaaa tgtttgatat
5221 ggcaagatag gtatggtaat ttcaaagtga attgggaatt cctctggctc atagaaccct
5281 tttttttttc ctttaagtat tcttgagata caaaaaaaaa aagtaaataM aatttcaaaa
5341 aaaaagttcc ggatctgttt ttaagctcca tctggtcctc ataacctgca agatttttct
5401 taaaaccttt cagctgaaag tgggggtaaa ggtggagtaa tctgtggatt tgtttctgtt
5461 gtcttttaaa atgtcaaata tataatatgt aattttttta aaaaccacca gatacagaaa
5521 tgtgctttaa catcagttga aacctaaat ttcttatgtt gtggtgattg tattaaaaag
5581 ggataaaaga agagtgtcaa acatggttaa atatattgta ctcatttatg ttgaatacgt
5641 attaaaatta agacaaatgg aaaattatac tttgagtata taatttgtta aatattactt
5701 tatatggtaa ttttatgtat aatttcatat attggtaaaa ttcaaaacta cacttgagaa
5761 tttttttatc ttaagtttgg ggtgaatggg gtggatgaga ctgattgaat agaaaagggc
5821 taatggccca aacattatat agatttcttt ttttcagtca gaggccttat ttgatatttt
5881 ataaataaat gacagttttt atttttaaac tttttattgt ttttgggaaa gtattcctta
5 41 atttaatgac acattcattc agatacttct tatccctgct aataaaggaa atctatttca
6001 agctacacca ttgagattaa gtctgaggca gttcattgag gcagctctac tataaaagct
6061 tacttgataa ataattattt ttgtaaacaa gttgggttaa cttattcttc gtctttttgc
6121 ttggatatga atttaaggtc ttcatgttta aagacattta ctttgttatt tagtgacaca
6181 tttccatcct attttttttt tttttttggt tgttgttaaa cagaacctta agtttatgtt
6241 tgaggtatgt actgcatagg aacctatttt attattaaag atgaatgatt aaaattggta
6301 tggtctccaa tttaatttga aaagtgct a cccKtattct tatatatggt ttaattttaa
6361 ggttttttgt ctcttcttag tgcaaaacta cttagcagtg acctctatct gtattcctta
6421 ggaattagca gcttcttagt gtggatcctg cagaacttct taccatttgt agtaggttga
6481 atcatgtccc ctagaaggta agtctaagtc ctaacttgat acacctggga aggtgaccat
6541 atttggaaat agtctttaca gatgtgatta ggggatctca ggatataatt accctggatt
6601 ttgggtgggc tccaaaccca gtgactagtg tcgttacaat aagagaggag gagatatgaa
6661 acacagatat agcagcatga ggacagaggc aatgagttac gcaaggactg ctagccacca
6721 ccagaagctg caagagaggc atggaatggg ttcttcacgg gctccagaaa ggaccaagcc
6781 tgcttgattt cagacttctg gcctccagaa ctgtgaggaa ataaatttct gttgttttca
6841 ttcacccagc ctgtggtaat ttgttagagt aaccctagga aactaagaca tctattgttt
6901 ttcatctatc aactatattt ttattttata taagaaagtt cttaaaaacc aatttataac
6961 ctcacaattt ctgctctaat tttatattct ttaatatcaa ggtgacttct aaaattttat
7021 agaaataaat tgcttccctg taatcccagc actttgggag gccgaaacag gtggatcagt
7081 tgaggtcagg agttcaagac cagcctagσc aacatggtaa accctgtctc tactaaaaat
7141 acaaaaagtt agccagggat ggtggtgggt gcctgtaatc tcagctactt gggaggccga
7201 ggcaggagaa tcgcttgaac ctgggaagσa gaggttgcag tgagccgaga tctcaccatt
7261 gcactccagc ctgggcaata atagtgaaac tccatctcaa aaaaaaaaaa aaaattgctt 7321 caatgaaaaa tggacaatcg tagatccata attttggtgg tcactacctt ttttcattgt
7381 cagagtgaaa taggagaaca ttttttagta aaatactgat gaagatgata atttctaatt
7441 ggaatttgag gagacacttt ttcctttaac ctctctggct gctcctcagt ctcctttgtt
7501 tcttctcgct gacctcttaa cattagagag ccactgggct tagtccttat acctattctg
7561 tgcagtgtct ctactcactg gtgatctcac ccagtctcat gactaaatac cacctctatg
7621 cttgatggct cctaaattca cagttccagc atagacctct caccccggat tcatgcagct
7681 gtgactgtca aagagaaatt ttatgcttaa gatgtccaaa gccaaactcc aaacctccca
7741 gaacgcctcc atactctttc ccatcctgct tgatgacaac tccatccttg cagttgctaa
7801 ggccaaaaac cttggtggca actttgactc cactttctca tatcgtgcat cctattcatc
7861 agcaaatcct gttgttggct cttccttcca aataaatcag aatcctacca tttctctcct
7921 ccactgctac ccctggtcaa agctacatta tggtagtgtt aaagtataca aattggattc
7981 aacctaaata tcctacagta ggggaatagt taaatgtcaa tattcactca atacagttga
8041 ttacagtcta tggcttgaag atgctagcaa caagaagaaa aaagtaccta aatatgcatt
8101 aaaaagctta acataaatta cccatataat tacaaatatg taaaaatcag atgcatacgg
8161 ggaaatgtcc tgaagcaaac agcatcagta ttcttccagc taattgtact gtttgcatta
8221 gccagtcagt ttctgatgcc tgtaaatcaa gcatttttgt agctaccatt atggagttgt
8281 aatttattca tcagttcccc caactgatgg atagtttgca aagtttaata caaaataatg
8341 cagtaaacat ccatatacat aactttattt attgtaattt ctagcgtgca aattcccaga
8401 agtttgttag gtcatgtttt gttatttttt aaatgaaaaa ataaatgtac actgttaaaa
8461 atcttagcat actaaaaaat ttacaattca gagtaaacct cttcctacaa cctctgtctt
8521 tccagaggtc attataagtt tcttgtgaat cagaaaacct gttaaccaaa aaaagtgact
8581 gaggcaagtg tcttaaatca gtagaggttt attgggccaa agtttaaaga catgccagag
8641 aaaaaacgca agccacatga gcatctgtga cctgagcttt ctaaagaggg ttttggaaac
8701 tcattattta ggggagagag tgaggaggga aaagggagag gggttaggca gtgaggcaaa
8761 tgattacatt cttgtgaggc tctgattaac gctcagtaaa tctatgtttc atataagata
8821 aactgaaaaa agggagtaaa gactcagtta ttcatctgtt tcagggtagg cagaagagtg
8881 gttgattttg tctcatcctt attctgtacc tgggaagata agcttgttat cagcattgtc
8941 agtgtgagat ttaacaaaac ttggttttaa gagttaaact taggttgcag acccaaggtt
9001 acaattggca tgtgttggtt ttacagctct ctacaatgag aaggggaggc cttgaggctt
9061 ctgttaataa tactcccctt cctacacatg acatacttgg ttttggctac tcctactcaa
9121 cctccaagtt tcagctggaa tgtcacttcc tcaaggactc cttccttggc atcccacttt
9181 ctagccctat cccattatac attttcattg catattacac atcttgtgta actattttag
9241 tatctgtctc acactccagt cccagacagc aaagaccatg cctgtgtttt ccatcttcct
9301 agtgctcaag gcaatgcctg gccaggaact caacaaatat ttaatgagtg aatgtgagat
9361 ctaagtcaaa gcctcactat catatatata taatttttat ttttttgaga cagtgtcttg
9421 ctttgtcgcc taggctggag tgcaatagtg cgatctcagt tcactgcagc ctccgccccc
9481 cgggttcaag tgattcttcc tcctcagcct cccaagtagc tgacaggtat gtgccatcat
9541 gcccggctcg ttatttttat tttttagtag agacggggtt tcaccatgtt ggccaggctg
9601 gtcttgaact cctgacttca agtgatctgc ccaccttggc ctctcaaagt gctgggatta
9661 caggcgtgag ccaccacgcc actcctgtat aacaattttt taaaaaatct taagcttgat
9721 ccagacctgc caacctctcc agtgtaatga ttacatggta gtccctgggt aagtccagag
9781 ttcccactaa cttaagcccc tctttgtgtc aatttcataa agagtggtcc ttgcaaatac
9841 aatggccaaa ttgccaagag gcatttcaat caacagtcag ggtaatgtgt attcttttga
9901 cataacagaa taccactgac tgaatggctt aaacaacaga aataatttct cacagttctg
9961 gaggctgaag tccatgatca aggtgcagca gggatggttt cctctgcttg cagatgctcc
10021 cctcttactg ctcttcacac ggtctttccc ctgtgagcac atgcacctgg tgtttctgtg
10081 tcctaatctc cccttcttac aaagacactg gtcagactgg attaggaccc accctaatag
10141 tctcaattta atttgaaacc tctttaaagg ccccgtctcc aaataaggtc acattctgag
10201 gtaccgggtg ttagggcttc aacatataaa tttgtttggg gggcacagtt tagtctatca
10261 gcaaaccata ggtagctgcc ctcccaacaa gggctgggat gcaatgaggg gctgtgccct
10321 agggcaaggc cctgttctca ggaaattaga accaagaact ctgggtttga atgaatgtta
10381 ctaacaggta ttaagtacat cacctaggag tgaacttcgg accaagtttc tattgtggag
10441 atatggatat tggaaatgtt aaatattatg taccaatcat ttgaaataaa tggtccatta
10501 cttcagataa ttaacttgga aaaacatgct ttcactgtgt aaaattaata attttcaaaa
10561 agaacgatcg tagcaatact tatattagaa acatcctatc aattcgttag cagaagaaaa
10621 tagaaaatac ctggttttac atctgtatca tgatgagtgt aaagcacatt tggataggga
10681 gtcaggcatc ccagttttgg tctgagcact gttagttgat aactctctga cttcatatca
10741 ttaacttaag aatttcctca ggtattaaag aggtcagtga acatgacctc tgaagtcctt
10801 tgaaggttta atattctagc aatttctttg ttggaatcag ttttctattt cacctgctac
10861 agaaaactca actggcctgt ggtacaatat acctagtatg gtttggcaac ctggtagcta
10921 acctataaca gattaatcag aactttctga aaacatttta aagaacagtt caacagagtt
10981 tcctgttaac tactactttt ctttagtctg acacacctga agtgctaata acaccaaatt
11041 agtcttttaa cacattgccc cagatttcat ttcctgttat tatctttgtg attttttaaa
11101 aatgaagaac tatattgttt gcccatatta aataactttt atagctatga aactcgtcat
11161 gtcttgttgc tgtggtacaa atataatctg aaaaatttta tgaaaatatt taatgaggct 11221 ttttagcatt tttttcaaaa tagggattta ttataaaaac tatacaaact ttttatcact
11281 cacaaatgat gaaaaatttt aaacaattag tatcctccct ccaaaatagt gtgttctgtc
11341 tttacagtct tcactggcag tgcattcaga tRgtatagaa aataacaaac attccatata
11401 actttgtccc tacagtaaat aattttttaa aacttttcat caagtttcag tgttaMtgaa
11461 gttaattata gacagtaagg attacagaat aagcagtaaa Yggtcacctg cactgtattt
11521 ttcaaagcaa aaattgtttt atattttcta tgttgtttta tcctgcccca aacacttaaa
11581 gcaaaagtta aatatttttc cagttacctg aaacttcaaa aatctattgt actttgaaaa
11641 aactttaaaa agcagcatca tttaaatagt ggttaactca taaacgtgta tgcaacaaca
11701 ttccacaacc ctaataccac tcaggcctgc agagtcacca gctcacaata attcagtgct
11761 ctgaaagctg gggggaaagc ccctgagtag taagtatgca acccagggtg tcgggtgctt
11821 tcttgtggtg aaacaagggt gtcaaaactg aggggactct ccaaggtcct aatgaaaagc
11881 agctcctcta aacacctgaa tcctttttga ctccattctc atcactttaa ggatgaagcc
11941 tttctgtaca aaggctttgt acagaaatta ttaaaaacta tattttacac taatgctaac
12001 agctaattga gcagaaagaa ctatgaagta caaatttttc taaggttttc ttattaatgg
12061 caatacagac tttttttttt tttgagacgg agtctcgctc tgttgcccag ggtggagtgc
12121 agtggcgtga tcttggctca ctgcaacctc tgcctcctgg gttcaagcga ttctcctgcc
12181 tcagcctccc gagtagctgg gattacaggc acctgccaca atacccagct aatttttgta
12241 tttttagtag agacagggtg tagtagtata tattctacta tactatagta gagaccacta
12301 tgttggccag gctggtctcg aactcctgac cccaggtgat ccacccgcct cgacctccca 12361 aaatgctggg attacaggtt tgagccaccg cacctggtcg gcaatataga ttaaggtggg 12421 ggttatttcc taaaaacaaa agtaatccat atgtcatcta atgcagttaa attaaagatc
12481 acctgttgac actatttgaa aaggccttga aaaaaaaaag ggggccatta tttggaatat 12541 aaatcaccct tataaaattc tattatctat ataaattggc ctattttcaa ataataattt 12601 agctatttca attaccattt taagcaataa aaggcaaaaa caaagggaac ctactgaatt 12661 gtacacttaa acatgaataa gaaggtaaat ttcatgtgta ttttatcaca acttaaaaat 12721 tttaaaaaat actgaaaaaa aaacaaaggg taacttttgg ataatgtatg atactaagaa 12781 gggcatgcaa ctaagtaatc agactgcttt tagtaagaaa ataagttttt ttttttttta 12841 atttctcgag acagggtctc tgtcacccaa gctggagtgc agtgacacaa tcaaggctca 12901 ctgtagcctc aatcttcagg gctccaggga tcctcccatc tcagtctcct tgggagctgg 12961 gagtaggcat gtgccaccat gcctggctaa ttttttaatt tttttgtaga gatggggtct 13021 tgtcatgttg cccatgtcgg tctcaaactc ctgggctcaa gcgatactcc caccttggct 13081 tcccagtatt gggattacag gtgtgagcca ccatgtctgg cttgcttctc tttttgtatt 13141 ctaaaattca aaggcctaag tatcaaatcc ctaaatctcc aaatactgtc acagataaag 13201 actcaataat aaactccctc cgaaagttta gacaggctca ggtgagagac ttgtttcaag 13261 gggttataaa aagaaacacc agtgctctgc agaagaatca gtttttaatt tttttaatgt 13321 atctatttaa tggaataagt tgatcataga tttgtaaacc aaaaggtaat ttctcaagta 13381 tttggaaata agRaaaagcc tccctaccac caaccttttg gtcatctttc tcattctctt 13441 acaatcatcc taatccccta gtacaccctt accatatatc aataagggca ccataatatt 13501 atgcaaagaa cagatatata tgcctgatct cttattagac ttgcaccaga gactgttgaa 13561 ccactccagg catgaactcc aaagctgagg cacactgacc aagcccctgg gcatctacag 13621 aagcaaaggc gttctctctc cagctggctg ctccttctgg aagagccctt taatctgggt 13681 taatcggcca tagagcctct ctctcaatgg aggaatgtgg tagctagggt ccagaatgtt 13741 tgtcactcgg cgctctctct cttgcttcca taacttgtat gggtggggag ggaagaacgg 13801 tcgtcctctc tctcttcgaa tctgtaacgt aattccactt acagccagca tgccccatac 13861 tgccaggata atgaagtcta aaaaacagta gaaaaagtac agtttgaact ctagtatttt 13921 aaaatctaac ataataatac aacccttcat ggactaaatc tgtatattcc tttctaatag 13981 actttctggt gagttagtcc aaacacatat gtagttcctc agttacaaac caaggaatca 14041 gtagggaagc cacagtctta tttttgaaac taggaatttt ctattacagg catttgaaag 14101 tccagacagg ttgtaaaaaa atcagttgtt tggatccttg gccttccaac attatgtaac 14161 aagtacccac agttgtttgt gtgttttttc agagggggtt cggggaggaa ggcagtgatc 14221 tagttacact tcacatatgt acatcatgga acatcagatt ccaccacgct catttctttc 14281 ccattccact ctacatgggg ccctactgca ctcacagtgt aggtatagga atgcatgaaa 14341 agattcaacc aatcgtactc agcttctagt aaagcttcta gcttggcaaa acactgtctg 14401 gtacttaaaa cttgcaagag ttttaaggtt ttcaaggatt tcaaggtctc taccatcaac 14461 ctcttatcca aagggaaagc tctggatagt aaagggaaag atttgcccta aaataaaatc 14521 acaacaatca caattgtgct tatgcaatat atcttcaatt ctaggacatg ctttttcact 14581 ctccacatgt caacatttct gaagtcaaca tatcttacaa tctgaacaat tcatgtggta 14641 gtcatttttt tcttcaaaaa atttatagaa aatctgtaat ggatagaatc ttacaagtga 14701 gggaaactat atgcttacta attaaaaact ctttcaacta gcaaactgca tgcttcatta 14761 aaggagggaa acaagggaat aacttaacat taaatcaggt tgtcattctc atcccttatt 14821 ccatccccac ccataagtct caaacatctt tactgtcagt atttttctcc cctctgagaa 14881 tgaccaggta aacctaaata atcttggaaa tttcttaatg aaattcattt agtagatttt 14941 tatcttcatc ttaaaatttt aaatgcttta ctcccatgat cctgagttat cataacagag 15001 ggttctcaca gcattgtatg ctgtgttccc tccttttgtc ccagttgact ttctttaaat 15061 ttagtttcca agtgctctgg ttagcatagg tgggtcaaga ctcctactgt gctgtcacac 15121 tggtttttgg atttaagagt cttaccatta gtttgaaaag gcacatttgt gaaagctctg
15181 tggaaatcct tgttgagcgc tctcttgagt acgttcaaag tgatgtagga aaggcttgtg
15241 gaccagtaac tgtcaatggc taaaaccacc gaataggagc caatgactcc acaagtcagt
15301 atgttcagct gtggaagagt ggaagagttt aggcatcatc catgttagaa caaaaatagt
15361 ttataactct ccactggctt caatcacagg caatcacatc tgctccctca ggcatgaaaa
15421 aggaccagac ccactcagag ctgaacagaa gttccctgga aagataaact gaaaacaacc
15481 ttcaacatcc atatgagttc ttaaaacaca gttcagctta tccaaatact atggaaaata
15541 tcttccatat gaaggaactt caacaataaa atctaattag aggaagaatc actcttctga
15601 agccagttga aactaatgac ccatcaggtt ggtgtactag agtaagcact accttctctg
15661 ctcccactgt taaaagcata ttgactgtga tgctccattt ggtggaaaaa aaagaaaaaa
15721 acaaacacca tgtggtaatc ataaatagaa cttcgttttc acagtaacaa ggctatttag
15781 aatcagtcat ctgatacagg taacacagcc ctccccagtg aataaaacat gcaaaatgat
15841 gaaataagtg atcagctgaa cacacaggat aacataatca ataaatctaa cttttgatga
15901 aacacttact attcttaggc agcccatgaa aactactgga atgaggatag ctatgcaaga
15961 gaaagtgacc cagaatacac catcatcatg aaaaatcttt aggtttcctg aaaaagcaaa
16021 aagaaactaa gagtaaacaa cagctttacc aagttagagt tggtttcttg gaacatctga
16081 acacagatat acatcaaagc cttaaagtaa caaccaggga atatgttggc aactagaaat
16141 gaattctaat tttcttcatt taactgtcaa tacaatcttc tttgaaggat gtgttctaga
16201 aggtgggtgg gaggaaccaa gcaggtσaac gctctgcact tattaacaaa atcatttaga
16261 agacactgga atagtccaag ctcttccatt cactagctct gtgaacttga gcctcagttt
16321 cctaaccctc aaaatgacat tgaattatat ctccaagctc taaatcacct gttagctcta
16381 cattgctgac ttcatgattt catactgcaa aataaaaaat acaagtaaaa ggcattcaaa
16441 gttaagccat gaacccaatg taaacagtga gtccacttaa cagattttta ccgtcaaagc
16501 atgtcctgtc atgccactgc acactgtgac atgtgatttc ctcatgtatc aggaaagagg
16561 aaccaaccaa ctatctgctc ttcccaaacc cttctcctgc tgctggactc taaaatgctg
16621 cacaacttag gccgacccag aacaaatata tgagaactcc tctttRtaaa ttaagtttaa
16681 aaagcaagaa taggctgact gctgtttaat actgacactg gcaccaccat tcagtccatc
16741 tgtaaatggc cccatacctc aagacctaca tatccaggtc agagtggaag actgggagtc
16801 cctaggctac aggactggac cttgagactc catattctct gaagccaaca gcaatatgcc
16861 attgaggtga acttatagat tctattctct agtttaacta tattaacctt cacaaaatac
16921 atatgtggct ttcttgtaaa aggctttcaa gaaatctaag tattgaaaat agttacgatg
16981 catgcatgtg aagaacggac cctttcagag aataagctca ttgcttccca cataaggtga
17041 aaactagcaa tctaatcaga ttgtagtggt cagccaaata ttttttaaat gctaatgctt
17101 aaaaatatgg gtaggcctct tggccgggca tggtggctca cgcctgtaat cccaacactt
17161 tgggaggccg aggtgaacag atcacttgag gtcaggagtt tgagaccagc ctggccaata
17221 tggagaaacc ccatctctac taaaaatata aaaatgagct gagcatggta gtgtgtgcct
17281 ataatcccag ctactcagga ggctgaggca ggaaaatcac ttgaactcgg gaggtggagg
17341 ttgcagtgaa ctgagactgc gcgactgcac tctagcctgg gagacagagt gagactccgt
17401 ctcaggaaaa aaataatgtg tgtgtgtgtg tgtgtgtgtg tatgtgtgtg tgtgtataca
17461 tatataggta ggccaggtgc agtggctcaa gcctgtaatc ccaacacttt gggaggccga
17521 ggtgggagga ctgcctgagc ccagtttaag accaccctag gcaacagtga gactctgtct
17581 ctactaaaaa taaaaRctta ccaggcatgg cagcacacac ctgtagtccc agctacttgg
17641 gaggctgatg taagaggatg gcttgagcct tagagtttga ggttgcagtg agctatgata
17701 gtgtcactgc agtccagcat gggtgacaga aagagatcct gtctctaaaa aataaaaata
17761 tgggtttgca cccactagca ttgaggagat gatcactcta acggtccttg agctatgaga
17821 tagttcataa acaaacatat ataaagggta tatgctaaaa ttatttttac caataggaat
17881 agttatgtca aaaagtttag agacaactgc tctagactac tttataaagt tgaaaattaa
17941 gagacctctt tatttctgtt ttctcattcc tcacatctat cctatgagat agtttcacag
18001 atgatggaac aaagtttcaa tacatcgtcc aaggttataa gctagaaagg gaactagtga
18061 cagagccaga atgcatatag aaggtttttt cctgacttta taatttatgc tcattctcct
18121 catgaaaagt acattaaatt actagaaatt ataacctatc atccctccat cctctaagca
18181 ttaacaaaag aggggaagcc cattaagtag tagttggttt ttgtggtctt tttgttttgt
18241 ttttgagaca gggtcttgtt cagtcgccca ggctggagtg caatggcacc atcatagctc
18301 actgcagcct caacctcccg ggttcaagca atcctctagc ctcagcctcc cagagtagct
18361 gagaccacag gtgtgcacta caacacctgg ctaatttttt tttttttttt ttcagtagag
18421 atggggaatc actatgttgc ccaggctggt ctcaaacttg agctcaagca atcctcccac
18481 ttggtctccc aaagtgctgg gattataggc atgagccacc atgctcagcc attaggaagt
18541 attttattta gcacatgtag ggtagagcct tgaatctgta tttcaaaaac atccccatgt
18601 gaatctgtca tttcgccaag cctacacaac actgcttttc atcagactat ccagtagtct
18661 tagaaaaaaa aagtcttcag agagacaagg gacacatgac ttgtactcta ttatatcctg
18721 cattctctat agagttgaca gcctcatgaa atggctattt ttatgtctaa cagtcccatc
18781 aactttattc tagtatttta agaacattgt cacagaaagg aaacaaccaa atagaatact
18841 tttgagtaca gatgctgttt ttgtttgttt ttgacaataa tcaggaaatg taagttatta
18901 aacaatggca aagaaagtta acttataagt taaccagatt ttaaaaactg atagcaattg
18961 aattactttt taaaaacacc aaaaaaaccc cagaaccagc cctgtgctac tgccccaggg 19021 tgattaagta cctgagggac acctggggtt tggcagcgga tgggagtgga ggttgagggt
19081 acaacagaag accagaaaca aagtaccagg ttccccgact cagctgccat cagagccttt
19141 acctccttat ttcctttacc tccattattt ctaataaaca cataccactt atcacaacaa
19201 atagatacaa agctacctct aaagacattc tatatttcat ctactgtgcc tttgaggaag
19261 gagggacttt tactagtcct ggtgctgtct gaaagtgtca caccatcaat gcagatttcc
19321 agaactccac aggagaagca ctgacatgca acaccactcc aggatgcaaa tccaattagg
19381 cagtattcaa acagtcactc gaacacacaa aacatctgtt acatatcgcc tacccagtgg
19441 agtaaagaaa gtcactgacg agatgaggaa ccccagcact agtccaacac agagcatgca
19501 gatcgagagg attccaaatc gccaccacac agctaccaag aacattccac cgacgcttcc
19561 agtgacagct gtcagaatca gattcactgt acaaagagag aggatgaact gctggataac
19621 cggcagtact tccaaccgcg tgccttagac atacaatacc gttaccagtg ccagcttcag
19681 ctttctgtag gtcaggcact gagggctctY cagtggtgcc atgaagccag catagagcaa
19741 ccctctctag ggaggggtct gggctgagac aaggaaatta gctagggagc taaacctcaY
19801 agggccagtg acaggcttgg cttgtcaata aattgggatt gagaaggaaa agttgacaag
19861 cattctgtta aacataatgg ggtagggagg tatctgtttt caggtaaaga aaacctcaac
19921 attttgcttg ttgtacatct catatcttca acatatcaca tagccagaac acaggtctat
19981 aatcaatatg gcccctcctt tccctaagta ccaaggaatt caccatacag attaaaaacc
20041 cagaaggtct gaatgagtag ttcagaaaag gtgttcagag actagatgga ccattatttt
20101 acataagtaa taggctgtca cacacaatat aggccaaact gtagaaggaa aggtgaagta
20161 aaacacagca cctgccttct tgaataccca gttaaactat ataattttca cttaccatca
20221 tacttgatag gtgtcagtct tgtaatcagt atataaaaga agaatcccat gatgataaag
20281 cctatgaaga ataattYtaa gtggcaaacc accaggaaag gaaaaaagca aaacaacaaa
20341 agctatggtt aagcaccctt tttacagtgc aatttaaata tttaatctac aaatacatgc
20401 ttaagctcct ggaatttaca tgttacagca ttcagaagaa aaaaaaaatc taaaaggcag
20461 aagaaattca gcagccatgg gagtaattat tattaaacag atacaatatt aaagtaccaa
20521 ctacaggata cactttcttg tatataggtc agtttccatt gttaaattgt tatttgttca
20581 tttcatagct cattttaata tatttatgtt ttctgcttaa aataagaata gcactttgtc
20641 acgtgtatgt gatacgaaat tacacattaa attttaatag ttttgtaagc agaaataaaa
20701 tgtaaaaggt aaaagaaacc caaactgtcc caaagcaaaa tataactttt atatcttctt
20761 ttaattcatc ctatcctgtt tagaatgatc aatcattacc ttcatccatt aaaacacctg
20821 gtaatgcaag tatacagata actttgttcc cacaaataag cctaatcctg atcatggagg
20881 ccatagctct acctattttc ttaaattctt cacagctgtt cttggtaata cttgtactgt
20941 atctcaattt caataaatat aaaatgMtac atatcaacac accaaaaaaa cccagagtga
21001 ggcatggtgg cttgtgcctg tagtctcagc tacttgggag gctgaggtgg gaggatcact
21061 tgaggctagg aatgtgaggc tgtagtgcac tataattgta cctgtgaaca gccactacac
21121 tgcactccag cctaggagac acagtgagac tccatctctt taaaaagaaa aaaaaaaagc
21181 tagtgataac tttgagacca cagcttagca actaagttct ttgttacaga atcattctac
21241 atgttgagat attatatatt ctttacaata ctctcttccc aattaataaa aaaagtgtca
21301 taatagcagg aaaggagttg ctatttcaaa caatttaaca taagtttaaa gagctttatt
21361 agatcaggat tacatttgag ctaccttgat gctcagttat acaacttgtt gattaaataa
21421 ggatttttta ataatcgaaa acatcactta tataaaaagc agcccaaata attcaaacca
21481 attcagtgag catgatttac atcccagttc ttcagtgtgt ttcactgatg ttgatgctgg
21541 cattcccttt ggcatctgaa tctctcagga ctgagcagac atttcaaact cactgtacac
21601 tgcagcccca tagcctgatt catgtgaaac caagtcaatc gccatcacca atatccacac
21661 atatttttac aaagacaacc aacttctttt ttttttttct tgagacagga tcttactctg
21721 tcatccaggc tggagtgcag tggcacaatc ttggctcact gcaacctctg cctcccgggc
21781 tcaagcaatc ctcccacctc agcctcccca tgtagctggg actacaggca cacaccatca
21841 agcctggcta attttttgta ttttttggag aaacagggtc tcaccgagtt acccaggttg
21901 gtctcaaact cctgagctca agcagtctgc ctgcctcagc ctcccaaagt gctgggatta
21961 caggtgtgag ccaccacaca cagccccaat ttgtctttaa ttttttggta gagaagggat
22021 ctcactatgt tgcctagact tgtttcaaac tcctggcctc acacagtcct ctcacctcag
22081 cttcccaaag tgctgggatt acaggcatga gccactgagc ccggccctga caaccaatgt
22141 ctaatctcgg ttatctttag tcaactaaca gatctagcag ctgataaaat tcactgcata
22201 attgtattcc cctgttaata agagaaggtt atactccgct gtagggagaa tagaaaaaaa
22261 taaaaatgca ttgcaactca gtagactcac gactacaaga ccccagctac aaatctatga
22321 agatagtaga gataagtaag tgcttactct cctcacaggt cattccccag caacactgaa
22381 aagactgcaa aatggaaata gcaactacat tggacataat acctgttttσ cagaatctgt
22441 gtccaaagaa acaaatgaag aaaccaagca gggcaaaaag agtgaagaac actttggaag
22501 acactcttcc taaaaaataa tgaaaattta gtggataata catccaattt gatactttgt
22561 attaatattt atagaacgaa ccttcatcaa aaaagctaag tgaactgaca taatttatcc
22621 catacatgta tattacaaat ttatctttaa aatactcttg ccacccctaa tgaatgaacc
22681 tatgtagaca atcaatatca acaactgctg ctataacaaa aagagaatcc agacaatata
22741 tgcttgctga tagcggtatg gaacacttcc tatgacatat tcctgggtaa agtggagaga
22801 aacagagaga gagtgttcct aaaacaaata atcctgtttc ttcaacaaat aaactgcatg
22861 gacaaaaggt ggcagggagt gggggggagg tggtgggggt gggtggaggg agaatacagg 22921 ttaaaagaga tttaaaagac acatcaacta aatactgtgt atagatctca tctgcaacct
22981 gattcaaaca aactgtggaa aacaattgag atgactccag aagcaaactc tggctgttaa
23041 tttgatgcta ttaaagaaat attttcaata ttttaaaatg aaaattatgt taatgacacg
23101 gtggttctat tttttaagtg cttatcttta aggtatacat actgaaatat ttgtgagtaa
23161 catgatgacc agggatttgc tttaaaataa tccagtgata aaggagggtg atgaggtgga
23221 gaggcagaga agcaggtaca gcacagctga aacaagataa tggccataaa tcaaaattgt
23281 taaggctgga taattggtgt atggaggctc gctgaagttt ttcacaataa aaaatttaaa
23341 ccgaaactca caatttaaaa acatgtatta cacttataag ttatttatta taatatttat
23401 tacacataca caaattacta ccagtcttat caattataca tattgccttg gagaaaaatg
23461 ttgcattaca accaatgatg aagcacggta tcatttagtt tactgaagag aaaaatatgc
23521 tcactaaatt catcacccac catcatgaga taaacccaag aaaataatcc ctgaactaaa
23581 acccaaaaca agacatctat acaatctcat gctaaaataa aacaaggctg ccacaaatca
23641 aaatacataa aatgcctaag agtgctcaga atggagaaac catgaagaca tacagtaaaa
23701 taagaaacac agacagaaga gcagaattca caggggatat aatacctaaa tatcagcttt
23761 tctgagaata aggagcccat aagaaagatt aaacaacagc cgggtgcagt ggctcacgcc
23821 tataatccca gcactttggg aggccgaggt gggcggatca cttgaggtca ggagtttgag
23881 atgagcctgg ccaacatggt gagaaccccg tctactaaaa atacaaaaat tagccaggcc
23g41 tggtggcaca tgcctgtagt cccagctact ccagaggctg aggcaggag attgcttgaa
24001 cccaggaagc agaggttgca gtgagccaag gatcaggcca ttgcactcca gcctggatgt
24061 cgcagccaga ctccatctca aaaacaaaaa acgaaaaaca aaaaaaaaaa acccagaaag
24121 attaaacgaa agataaaaac accacattgt ttatttcaga cctgtggttg actatcattc
24181 tagaatttaa tttttacacc aaaaccatta aatttgctgg gatgattttc tcaaatgaaa
24241 atcccgtgaa cttttcagca agtataatca ccaagacagc aaggtcttcc aacccaataa
24301 aaactaagac acagttagat actcttccat aacattagag gggaactaaa tcccctatca
24361 caataccagg aaggagggag agaaacaatt atacaagtaa aatgagaggg tatggaaggt
24421 tccatcaaaa gcagaatcta cgataaaaca agacataaaa caggcattca ctctggggga
24481 atgaaaggag tgaatagact aggacaggag caagttgaag gttaaagtgt ctttaactat
24541 gacagtattg ctaagggtta tgaaccacag ggcaaggttt tagttaggag gcaatatgga
24601 tatagtctcc ctactccaag ctcaggaaaa gcactctaat actcatcaat cttgaaaatg
24661 agagtaacaa tagaactaac atcactagga aggttcaact ttgggcggga agaacaactg
24721 gatcagagct ctctgtctcc taagcctaac agagagagac aggcctgggg gcctttctat
24781 ttagaagggg cttttgcatg aagggttcaa gggaaagaaa tggaggaacc cagacatact
24841 tcagtccatc ggttaaaaat atatggccag gcgcagtggc tcacgcctgt aatcccagca
24901 ctttgggagg ctgaggcggg tggatcactt gaggccagga gttcaagacc agcctggcca
24961 atatggtgaa accccatctc aactaaaaat acaaaaatta gtcaggcaag gtggcgcaca
25021 cctgtaggac tttgggaggc cgaggcgggc atatcacctg aggtcaggag ttcaagacca
25081 acctggccaa catggttggt caggtctcta ctaaaaatac aaaaattagc agggtgtggt
25141 ggtacacgcc tataatccca gatactctgg aggctgaggt acgtgaatta cttgaacctg
25201 agaggcagtg gttgcagtga gctgagatca tgccactgca ctccagcctg ggtgacaaga
25261 gtgagactgt caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaatatatat atatatatat
25321 atatatatac acacacacaa acatatctgc caaggtctct tgcattgtat ccctcaagga
25381 tcttgagtgg aagattgtct tgagtggaag actgagtggt gacaaagagc ctttgcttgg
25441 ccaaatttct ttttcgtttt tttttttttt tttttttttt tgagacagag tctcgctctg
25501 ccgcccaggc tagagtgcag tggcgcgatc ttggctcact gccagctccg cctcccgggt
25561 tcacaccatt ctcctgcctc tgcctcagcc tccctagtag ctgggactac aggcgcccac
25621 caccatgccc ggctaatgtt ttgtattgtt ttttttttta gtagagacgg ggtttcactg
25681 tgttagccag gatggtctcg atctcctgac ctcgtgatcc gcccgccttg gcctcccaaa
25741 gtgctgggat tacaggcgtg agccaccgca cccggcctgc ttggccaaat ttcagtctcc
25801 tgaaccccct cctaggccca tctgcgcaca tctttgtaaa atccagcttc agcaagaact
25861 ctgataagtc agcttagcaa gaatccccta tgcttgatat caaatcaccc tcgatatcta
25921 atcgagttct tcatcctcca ccatccatcc cccaggtgat gtctgaccac cctggtctgt
25981 cttcagtaag aatcccctta ggtcagtgca gacagaatgc σcccttgccc ctcatgtttc
26041 ctcttagaaa ttttccatcc actgactccc accctactgc ttggctacaa attcccagta
26101 gcccatgttg tactcaagag ttgggcccaa tctctcttcc ccactgcaaa attccatcac
26161 agtggtccct atgcctattg taatactacc ccccaccttg aataaaatct tcctcactgt
26221 gctttaacta gtgtcactga tttttttttt ctttaacagc gggatacggc tctagcagag
26281 gtagagaacc ataatctctc gcttgaacac aactaataga ctttcttctt tagagcaaag
26341 ctccttgaaa gagctacttg aactttctcc agtttctgtg ctcccagctc ctatttgttc
26401 ttgaatatgc tccagtcagg cgcctacccc acctctccaσ tgcaacagct ctcactggta
26461 ccaatggcct ccatgttgct aaatccaagg gtcattttca gtctctttct tagctgacct
26521 atcagcagca tctgccaaag ttgattactc tctcttccat gcaatactgt ctccccttgg
26581 cttcaacata catcactttc cttttaccaa tctggctgca gcttctcagc ccattggtag
26641 gatcttcaat ttcctaagct ctaaacattg gagcacccag ggctcagtcc tcagacccct
26701 cccttttctc taagtcacac tgagtgtgcc tgcctctccc acctcccctt ccacctctgc
26761 ctccccttta tagataacac catttagcat gaggccttaa atgccatata ttcagtctga 26821 agatttccaa gatgctctcc agctaagact ttcctctgaa ttccaggctt atatatataa
26881 tcaaccatca gttaaacatc tgcacataaa tgctcaatag ggttctcaaa ctgaacttgt
26941 ccaaaactga actcttaatg tatcctccca accttctcct ccaacagtgc ttcccacctc
27001 agcgaatggt cgctctctct ctccagttgc tcaggccaaa aactacaaag tcctttacac
27061 ctctttctct caaacccctc atccaatcca tcagtacact gtactccaaa catatccagc
27121 cactcatgag ccaaatctgg aacaatttga acatgaaaat aaatgatagt aaaggatttc
27181 atccagagaa taaaatagga atctacaggt ccaggtttaa aataaataca tggataaata
27241 aatggcaggg gagggaaaac ccttcctcag agcaggatgg caacaaataa acatagaagg
27301 agtgatacat tagagaaaca ccatttggca accacctagt aataaatgtt tcaggcaaag
27361 atcactggat gccaaaacta gcaagtgaga gtttgagaat gggatattta ctgacactcg
27421 aagtacctcc cctaaagaca cttaaaaaaa ggaacagtta cttcagtgga gaaacttggc
27481 aagacaccaa taaccaagtc atcaaggatg tcaccaccag taaagagaca aataaataaa
27541 gagacaagtg tctcctgaga aggacacatc acttcctttg tattcctgcc aaaaaagcat
27601 aatcaaaatt taattatgag gaaatatcaa agtaacccaa attgaagaca ttctaaaaaa
27661 aataaatatt ctgtacttct caaaaaagtc aaggtcttaa aagattaaaa ttaaaaaaaa
27721 aaaaaaagac ttgttccaga ttatacaact ataaagagac acatcggtta aatgcaatgt
27781 gggatcctaa actgaaccct ggacagggga aaaaaaaatt tgttgacggg gagacggggt
27841 ctcactctgt tgcccaggct ggagtgcaga agcacaatca cggctcactg cagcctcaac
27901 cttcctgggc tcaggtgatc ttcccacctt agactaccaa gtagctggaa cgacaggcat
27961 gtgccaccgc acccagctaa tttttgtatt ttttgtagag acggagtttc gccatgttgc
28021 ccaggctggt cttgaactct ggagctcaag caatccgccc atcttgacct cccaatgtgc
28081 tgggattaca ggcgtgagac actgcaccca gccaaaaata attttttttt acttataaag
28141 gacactattg gaacaactag taaatgtgct aacgtgtgaa ttaaataact actgtatcag
28201 tgttagcttc gtaattttga taattttact atggttatgt aaggaaataa atacagaagt
28261 atttaatggc aaaaaggtct ttatgtctgc aacttactct catatggttc agagaagaaa
28321 attgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta cgtatctata catacacagt
28381 cggcccctga acaacacggg tttgaactgc atgggtccac ttacatacag actttttttc
28441 agtaaaagtc acactgagtg tgcctgcctc tcctacctcc ccttccacct ctgccacccc
28501 tgagacagca acaacaaccc ctcctcttcc tcctcctgtt cctattcaat gtgaagacga
28561 tgaagatgaa ggcctttatg atgatccact ctcacttaat gaatagtaaa tatactttct
28621 cttccttatg atttccttaa tgacatttac ttttctctag ctcattttat tgtaagacta
28681 tagtctatga taaatataac atacaaaata tgtgttaatc aagtatttat gtaatcaata
28741 aggcttctct ggtcaacact aggctaatag tagttaattt tggggaagtc aaagttatac
28801 acgggtgggg tatggtggct tatgcctgta atcccagcac tttgggaggc caaggcgggt
28861 ggatcacttg aggccaggag tttgagacca gcctggccaa catggtgaaa ccccgactct
28921 actaaaaata caaaaattag ccagggatgg tggtgtgtgc ttgttaatcc cagctactca
28981 ggaggctgag gcaggagaat cacttgaacc tgggaggcag aggttgcagt gggccaagat
29041 catgccactg cactccagat tgggcaacag gagtgaaact atgtctcaga aaaaaagaaa
29101 agagttatac acaggttttc aactgcacag gagtcggctc ccccacaacc cctacactgt
29161 tcaaaggtca attgcatata gagagagaag aagagagaat gaaaagcaaa tagcctaata
29221 cattaagctt tgaggaatct ggatgaagat tatacagaaa ttctttatac tatttttgca
29281 tattttctga gaaaccattt caagataaac tgctaaatac acacacacac acacacaccc
29341 ctcacaacac cttcactgcc cccattctac ctaacctagt tatctctccc ctggattact
29401 tcagtggcct cctaaccaat ctgcatttct gctcttgcct ccgtcttttc tcaaaaagca
29461 gccagtgatc tcattaaaat atcttagatc atggcaccat ttgctcaaaa ccttccaatg
2g521 cctttccctt tcattcagaa tagaagcaaa atcccatact acagtctaca aggccacaca
2 581 caggctgcct gcccctgcac ctctcacctc acctctactt cctttgccct cctcgttctc
29641 ctgcaacccc tgtcatcact gcagttcttc acaccctcag acaggctccc aggtgcaggc
29701 cctcatcctg gctgctccct ctgcctggta catgccacac ccaggtacgt gcgtggtgca
29761 tcaaggactg ccctggccat gctatctatc tcaaattttc ctcttactgg catgtgttat
29821 ctccctttcc tactttattt atcttcttag cactcaccat tttctcacgt attacatatt
29881 ttataaattt atcttgtctg tctcatctcc ctcactataa tataagctcc agaacaagta
29941 tttttgctgt tttgtttact gctatgtccc agtgcctaga acagagagtg gaataacgta
30001 ggggctcaaa aggtatgtgt tgaatgaatg agaactagac aaaagcatta tctgcaaggc
30061 caaaggagaa tttgtaaaag tttaaagcca catactcacc tagggaagca caactaccct
30121 ctcctgcctc aaagctgcaa gcgtatgtgt gagcaggaat gtaggcagca gatgtattta
30181 gaaacgggtc ccaaacaatg acattgtata tgacaccttg tcccgggagg gaggagaagg
30241 aaacacttgt cttatcatta gctgttaggg taaccacctg aagccaaaaa taacacatga
30301 ttagtgttta ggggattttt ttaagctatt ctgtgataat cccacctacg tgtaatatta
30361 aatggtatat tcataaatta taattcttgc ttaaaatata caccaaccca tttaatatgg
30421 tcaaaaggcc atcttacatg gtttgtatgt gctaatgtaa acaagctctc acacaaaatg
30481 cttccaaagg ttttttttaa tagtttaagg aaaatgcgat ataaacaatg tataaatgct
30541 agttacgacc atgaaaaaag ttttttcacc tctgctagac tataaacaag gatgggaact
30601 gtatttctct tgtgcactgc tctttcctca gtgtacagcc caatgcctaa cacagaggat
30661 gtgtccaatg ttagccacag actaacgcag acagtctgtt aacatctcgc agacagtacc 30721 cacttatttt tgtctaacag tctctgaaac aagaaaatat tacatgaggt tttgttatgt
30781 agtagtagtt cttttttttt tttttttttt tttgagacgg agtctcgctc tgtcgcccag
30841 gccggactgc ggactgcagt ggcgcaatct cggctcactg caagctccgc ttcccgggtt
30901 cacgccattc tcctgcctca gcctccccag tagctgggac tacaggcgcc cgccaccgcg
30961 cccggctaat tttttgtatt tttagtagag acggggtttc accttgttag ccaggatggt
31021 ctcgatctcc tgacctcatg atccacccgc ctcggcctcc caaagtgctg ggattacagg
31081 cgtgagccac cgcgcccggc cagtagttct taacttcaga aattccattg taaactataa
31141 aatagaagaa acaaatgctt tatagaacca taatacctat gttcctacta atttgagaaa
31201 aataaatatt agggttttag gagaaaatta ttatgagccc tcctacatca gactaccatt
31261 gtttaaaaat actgcttagc cttcaataac ttgcttcctg ggcaaaggtc tggtaaagtt
31321 caacaaactg ttaatattac tcccaagtta caatgaaaag tttaaaccag acagaaaagt
31381 tgaatgaata acacaataaa tagactatat actgcctaat atcaacaatt gttaatattt
31441 tacatttgct tctctatcac tagtttctcc ccaactctac ttttttcctg ctgaaagtaa
31501 gttacagata tcatgacatt tcacttctaa acacttcact gtgcatgtcc taccacagtg
31561 tttctcaaat ttaacgtgct tgtgaatcgc agggggcagt cttgttaaaa ggtagatctg
31621 attcttaggt cagcgtggta ctagcaattg tgcctttcta gaaagctctc agatgatgcc
31681 aatgctatgc aaacacctac cacactctga gtaacaagtt actcagtaca gatgtaagtc
31741 taagtacaga cttacaaggg ggttacatca ggataaaccc atcgtaaagt caaaatgcat
31801 ttaatgtacc tcacccacca aacattatgg ctttacccta gcctacctta aatgtgctca
31861 gaacacttac attagattca gttgaacaaa atcatctaac acaaaggcta ttttattttt
31921 ttattattat tattattatt attgagacgg aatgtcgctc tgttgcccag gctggagtgc
31981 agtggcacga tcatctcggc tcactgcaag ctctgcctcc caggttcacg ccattctcct
32041 gcctcagcct cctgagtagc tgggactaca ggcgcccgcc accaccacta cgcccagcta
32101 attttttgta tttttagtag agacagggtt tcaccctgtt agccaggatg ggctcgatct
32161 cctgaccttg tgatcctccc gccttggcct cccaaagtgc tgggattaca ggcgtgagcc
32221 accatgtccg gcccacaaat gctattttat aataaagtgt ttaattgctt atgtaattta
32281 ttgaatacag tacactgtaa aatgttagct attacccgtg tggttaagca ggagcgatgg
32341 ctcactgcca ctgctcagcg ttgcaagagt atcatactgt atattgctag ctcaggaaat
32401 tatcaaaact aaaatcaaaa gatcataagt caaaccatca taagtcaggg accatctgta
32461 taagaatatt ctcctatata acaatacctt agctcaccta cgaaaatgaa taaYttctta
32521 ttagctaata aatgatccag attttcccta atgtcttttt tttttttttt tttttttgag
32581 acagggtctc actctgtcgc ccaggctaca gtgcagtggc gtgatσtcag cttactgcaa
32641 cttctcccag gctcaagcga tcctcccacc tcagcctcct caatat ctgg gactacaggc
32701 acgcaccacc acgcctggaa ctttttggtt tttttagtgg ctgtgaggtt ttgccacgtt
32761 gcccaggctg gtctcaaact cctgagctca agtgatctgc cctccttagc ctcccaaagt
32821 gctgggatta caggtgtgtg ccactgttcc tggctcctaa catctt ttct agcttttctc
32881 cttcttaccc aagatcaaac caagttccat gcatggtgtt tacggccaat ctcagtaatc
32941 cagagcagtc tgtcccacct ttctctccca gctacccaat gactgt gaa gatgtgaagt
33001 cagtattctc ataaagtatt ccacaatttt gtgtctaact tattctttta tcccccatat
33061 ttcctgtaaa tagggaatcc aatggactaa attcaggtta gacatttttt gctagaatat
33121 accacaggtg atggtgataa tgtcagactg cactacatRa gcacgtaata caggctgatc
33181 cattttcagt gaaactagct ttgcccacct ggaataggtg gagactataa ggtcactcca
33241 tgttaaagtg gttctccttt tacaatgaga attaatctaa ggatgctact tagacaccct
33301 agaaatatcc tgttccccaa aaacctttca cctgctgatc cttgctggaa ttatttcatt
33361 gagggtcaca aaatggtgat catctaattc tattatttct tctacatata ttagccagca
33421 ctcttctgca aagagctttc tctcaccaac tggggaagaa ttagttcctc ctttaaaaag
33481 gcaagctaaa tttctttatc aatttttaga gtaatttgct gtaagagtct cctccagtgg
33541 tggcaactga ggaaggtttc atttgtattt attcaaggct gacaaσcaca gtctttttct
33601 tgattcttga actgccccaa atttggcagt gcaagcccct tcaaacaggc tcctgaatct
33661 ctttgacata ccctcattag tctttgaggg tttccccaca ttctggtaca aaatattctt
33721 ttaactaaaa gtttaaaagt aacctacaaa aagcctatta tacaagttct tatattcttc
33781 ataaaaataa taatagtatt aaaatgtcat atctaataaa gcaactaata aactttacta
33841 acagagcttc ttattttgtg aataagcaca atgacgctgt ctagaaaaac tccacccatc
33901 aaccattaga ctgaaggatg acctcatata ttatattgct gttaggcact tttcaagaca
33961 taaagataaa atcctgccct ccacaaaaat gatctattgc agtgagtctc aaaatttaat
34021 atgcataaaa atcacctgag ggctggagtg caacagcacc atctgggctc attgcaacct
34081 ccacctcctg ggttcaaaca attctcctgc ctcagcctcc caagtagctg gtattacagg
34141 catctaccaa catgcctggc taatttttgt atttttagta gagacacggt ttcaccatgt
34201 tggacaggct ggtctcaaac tcctgacctc aggtgatcca cccgcctcgg cctcccaaag
34261 tgctgggatt acaggcgtga gccactgcac ccagtcagaa tcacctgagg gatataaaat
34321 gcaaattctg attcagtagt tccagggtgg agtttaagaa ttacaattct cacaaactcc
34381 ccagtgatgc caatgccact ggtccatggt ccacacctgg ggagcaaggg tttacatgga
34441 ttcaaaagct cagagaagaa ttttactcca agttagactt tgagtttggg ttcaaatatg
34501 aatgccaatg tgtatatcct taagcagttt ctcattattt ttttctcaaa acaatgtaat
34561 cttcatactt gccaaaaatg tttacccagt agtcgtggga gtacacagaa aattaccacc 34621 tccttccatt cacatttcag attaccaagt cacagatgtg gctgcaacta aaacgtaaca
34681 taatttacat gcatctcctc aaaggccaac atcattttga gatatcacca gcaaagactc
34741 ccaagatgat aacaaaagag aataaagtga gtgtccccca aaaaggagaa aagagtaaag
34801 aaataagatc ctggtagctt ctccccttct caactctgac aaaggtgtca caatccagcc
34861 acacaaatca tgggactcag atttaccttg agagcactgg ccttcacctg gggcacactg
34921 accatcctct gcagatgctt cagcaacatc tcctcagtga ggtcattctc aggcagaaaa
34981 tactgataga catcatactg caacctccac ctggagtcct ggtctgtccc agcgtcacat
35041 ggtgggggat ctacgcctct aaagtcaacc aacaaaatga aacatcagtc tcttgtggtg
35101 caagtcccat ctataaaaag gaaccaagag ccctaatttc aaacacttgc aacaataatt
35161 acaatttaac agttcacctt ttgcagtggc aacaattggt attctgaaga aaagtaatgc
35221 actgttatgg actgaatgtt tgtgtctccc caaaattaat atgctgagac cctcactccc
35281 agtgtgatga tattaggagg tgggaccttt ggaaggtaat taggtcatga aggtgaagcc
35341 ctaatgaatc gaattactgc cctcataaag gagatcccag agagccctct agccttcttt
35401 ctgtcatgtg tggacacaat gacaacccag cagtctgtaa cctggacgag aaccttcacc
35461 agaactcaac tgtgctggca tcctgatcgt ggacttctac cctctagaac catgagaaag
35521 aagtttataa gccacccagt ctgtgctact ttgttacagc accacaaact aagacaaaca
35581 ccaacaggca aaggtgatta cataactgga ttctgatatc agtcaggcct agagtaaaat
35641 actaσagctc tggggaggca aaaaaatttt ttttaaaaaa aagctgggtg cagtggctta
35701 tgcctgtaat cccagcactt tgggaggctg aagcaggagg attgcttgag ctaagaagtt
35761 caagaccagc cagggcaaca tagaaagacc tcatctttga tttaaaaaaa aaaaaaagaa
35821 gaagaatata gcagatttgt catttgttag caagtagggt aacctccata acccctaggg
35881 aaactttctg taaaataaca gcaattgccc ttcttcataa aattgttagg attaaatggc
35941 aaagaacata acaacactca gcaccacgga caatgcacag gaagcattca agtgttctca
36001 aatgttagct atcattacta ttaaagcaga aactgaggca cagctttaat taaaacaatg
36061 aatctttata aaaataaaag gatgtttcag ggctactgag tgctatctat atttaaagtg
36121 ctt tataaaa accaggatgt attttcaagc tcataataga ctcacatctg gctcttcaaa
36181 taaaaagagt tcacaagaat gaagtgggaa aatattaact gtaaatgaca gtccaaatat
36241 taa agtgaa gtttaaatta catcaattcc ccccaaaaat taactcaatt ttactacaga
36301 gaattaggga cttgagagag ctggtcaaat ctacacaact gtcgtcatgt atattctaaa
36361 agcatttctc agacatggga gacagacgta cctcgcatag cctaggtttg ctggggcaaa
36421 cttgatagtc gtttcaaaga aattatactc caagtaaatg ttgggatcaa tatctaaatc
36481 gaactccaaa ttacagcctc cagggacagg atctggataa gaaataggga agttactaaa
36541 caaacaattc ctacatatcc aaatcatact cagaaaaaca gaactctatc tactcttaca
36601 aaaacttccc aaatagaagt taaatataaa cgtagagctt ctagtcgtat actatttcat
36661 gaactgaggt taaagagggt agagttaact gaggttcagg gccctagagc agggcagagc
36721 caaaattttc tgtaaaaggc ctaatagtat tttaggcttt gtcagtctga tggtctctgc
36781 ag aactacc caccccagtc cttgtggcag gaaagcagcc acaggcaata cgtacaggaa
36841 gaggcatagc tgtgtttcag taaaacttta tgtacaaaaa caggcagcaa gctggatctg
36901 gc catggtc tgtagtttgc caacctttcc tctagagtta aaaagatcgg ctattggttg
36961 ac cttctg gccaggtttg gaatgcagat acacagtgtg tatatatgtt tcaatatcat
37021 gttggaatct tcctccaaat tctatgctct tctttcatac tctccttttt ctgcacttat
37081 ggatctttac cacaccacaa atggtatgta tgccagctga agctcctctg ttcataattt
37141 ttc tttgtac actgtccttg acgcaagcct taattaagtc tatggtttct tatcaggtaa
37201 ttagcctttt gttatagcta acatttccta tcttctactc cagtaatctt ctggattctc
37261 cctcctttcc taactagcgc tccctctcct tccctttacc cccaagcttt aagagtagtc
37321 taaatttatt cacctcacct tcactcctcc atccctgttg tgccactaaa gtgactctca
37381 taaagggcca ccgctgactc ctacttgctc tagcatacgg acactttcag tcagttctct
37441 tgacctctcc gtagactgta acttaccact tccttttttt tttttttttt tttgagacgg
37501 agt cttgctc tatcacccaa gctggagtga agtggcgcaa tctcagctca ctgcaacctc
37561 tgcccaccgg gttcaagcaa ttctcctgcc gcagcctccY gagtacctgg gattgtaggc
37621 ace tgccacc acacctgact aatttttgta tttttagtag agatagagtt tcgccatgtt
37681 ggccaggcta gtctcaaact cccgattata taaattatac ctgcaacctg cttcggcctc
37741 ccaaagtgct gggattacag gtgtgagcca ccgtgcccgg cctgctccct tttaaaggca
37801 gaaactccag gctttcttcc taccttcttg actactccac agtgttgtgc ttattcctca
37861 ggagttatta tccaccagaa acagtgcctg acacatagta ggcactagta aagtatttgc
37921 tatgattttt ttgccctaaa tatccaagta catgcctgga taatctcact cactgccaca
37981 get tttatta acagctattt agttgggaat ctaatctcac ccctccactc caggccctta
38041 tttaaattat gtactctgca tttccatcca aatgtcctac aagcatctca gactgtgtcc
38101 caaactgaag tcatcaccta ctccgtccca cctcccaaaa catccagcac caccataacc
38161 ctgttcctac acctattttg tatcactatt tccctgctgc ccaaatagga aacctatgct
38221 tccctcttat actccataac caccagtcat tgtgttgtat caattccacc ttctggatat
38281 ctcaaatcct gctcctcttc tccatcccgc ctctcatggc ctctgttcag atcctcattt
38341 ctcattttgt gctgagtcct gactctgctg cgccctctcc aatccatccc cacactactt
38401 ctagagttag ctttctaaga gatgaaatgg actacaccat tcctctgctt aaaaactcta
38461 tgcctcctta gaacctacct cgaaataaag tacaaacctc aaattgtatg caaggccctc 38521 cacactccag ctgcagccac actcacaacg tgccattctc caaatcattt ttcttcatga
38581 cgtcgagctt actgcttctg cttagaacaa ctaaactgtt aaggactatg tcttgcctta
38641 actattactg cttctccaag ggctccctaa atgtttttcg aatgaataaa catgttctcc
38701 tagtcactac ctgagctttc agtcatcgtg ctaattctct tactataaaa tatttctgat
38761 tataggctgg gcgcagtggc tcatgcctgc aatcccagca ctttgggagg ctgaggcggg
38821 cgaatcacaa ggtcaggagt tcgagaccag cctggccaac atggtgaaac gccatctcta
38881 ctaaaaatac aaaaaattag ctgggcctgg tggcgggcgc ctgtaatccc agctacttgg
38941 gaggctgagg caggagaatc gcttgaaccc gggaggcaga ggttgcagtg agccgagatc
39001 gcgccactac actccagcct gggtgacagt gcgagactcc atctcaaaaa aaaaaaatcc
39061 gattatataa attatacttg caacaaacaa tctcaatagg ataattttcc ttaaagtttc
39121 atgaacacat tccatattcc aaagagtaag agggaggaga agacagaagg gttacctctt
39181 tctgagtagg agagtaggat agccatattc tggacaggct gtatgcctga agtccccaag
39241 taccaagtgc atgtactctg ctctggtcta aggatgaaaa ccagtccact ggcagtgcct
39301 gtttccgagg aattggaaag gagagtctgc agtccagaag aaacattgtc atgaatagga
39361 agtcgaccaa aacataaatt actgagctga tccagtgtgc atgtcctatt ccaaatcttc
39421 ccaaaacaaa tagaaaaaaa aaaccttcct taaataacca gggaattctt ttcatctcta
39481 tgttcacatg cccacacata tacatggaaa aagcattctt gaaaaatata cgattgtctt
39541 agttaaggct gctataacaa agtaccacag gtaaggtggt tataaacaac agaaatttat
39601 tttcgcaatt ctagagtctg gtggttcatg atagcggtgc caacacagtc gggttctgat
39661 gaaagctgtc ttataggctg aagactccca acttcttgtt gtatcctcac atgacagaga
39721 aagggcaaga aacatatctg gggtcccttt tataaggcca ctaatcccat tcatgagggc
39781 tctaaatggg ggcccatgac ctaatcactt cccaaagact ccacttccta atataacaca
39841 ctgaggatga gtatttcaac tgtgaatttt gtgaagacac aaacattctg tctgtaaaaa
39901 taatctttga tcaggaatag cagatgcaca gtgaaattcc caagtgtttc aattaatttg
39g61 aattaagatt tactatgtca aataatgttt tatcttagtt tctaagacca ctaggacaaa
40021 aacatgagac ctggccccaa ggagttcagt tttcgaggta ccttttaaat tgtgttataa
40081 ctgacaaact ataaactgta cataaagtat aatttttctt tttttttgag atggagtctc
40141 gctctgtcac ccaggctaga gtgcagtggc gcgatctcag cttactacaa gctccgcctc
40201 ccgggttcac gccattctcc tgtctcagcc tcccaagtag ctgggactac aggcgcctgc
40261 caccacacct ggctaatttt ttgtactttt agtagagacg aggtttcacc atgttagcca
40321 ggatggtctt gatctcctga. cctcgtgatc cgccagcatc agcctcccaa agtgctggga
40381 ttacaggcgt gagccaccgt gcccggccca taaagtatac ttttaagtgt tgatatacag
40441 acacctgtga aaccattacc acaatcaaaa tagcaaatgt atgcatcacc ccaagtttcc
40501 ttgtgcccct tcctaatcct tcctcacaca cttcctctct accatccccc actcccatct
40561 gcttggaaag ttttttgaat aataaaatgc taagctaaaa ggtaacagac tcaagaggtt
40621 ctatcaaagc taaggaaatg ggaaggaaaa ggtagcagag tagtttcaat ttgataagca
40681 taagaaagaa tgactcaaat attaattgat aaatgatcaa gtcaacagtt tcaaagagcc
40741 aattgccatc acgactcaaa aaaaacaaaa gtgccacact ttattaggaa gggcacagga
40801 aacagaagca cttctcttta cacagaccac tcacttcctg agccatgtgc agttctggcc
40861 atcatcttct aagtaatata acagtgggaa ctaaaggcag tccaagaaat aaaatgataa
40921 ttaaggacaa ctaagaccct ttctgcatag aaatcaaggc ccaagatgct gccagctagg
40981 tctgttttat cactggtgat gctgacatct ctttatccaa gttctgcttc ctcagatgta
41041 gaaataggca tcactactaa tttgttgagc tttaatgaga attaaccata tggaaaccaa
41101 acacaggggt tcctaactgg gggcctgaga gtctgagttt ttgaagggcc ccatgaaatt
41161 ttatatttat atttgagtcc atagacttga gcagtctatg gctccaggag cttaagaacc
41221 actggcctag gacatagcag gcgttcaaσa aatataaaYc cttatttcac ccatcctctc
41281 tcttttcctt caaatgttgt cttgctgtaa tgtcattagg aagaaacaYa ctgtttgtca
41341 attaaaaatt gttttaatag atctagttaa aaaagagaag aagaaagaac tcatctatgt
41401 gccattttac taagtctcct atgtaagagt ctgaatagga agctgtcttt tgaattcagt
41461 gccataaaaa acttggcctc ccctgaggaa ctggcatgct ccttcctttc taaggaagtt
41521 atgaaattta acatgcttta ccttctgctt tagctgcaaa gaacttgggc aaattcgacg
41581 tatgtgtgac atcggtatct cttgtaatta atactattta ttcctttcct tttttcctaa
41641 gctgaattct tccatttcta gtctattaac taccccccta cacacatacc ccacaacaca
41701 cacgcacaca cgtgcacaac cacatgcaca caatttccaa acctctatgg taggggaaag
41761 aaggcaggaa taaaaataca. caaaatagta agaaagatag tgtgaccaat gcctctaata
41821 ttatatatgg gctggggcgc agtggctcat gcctgcaatc ccagcacttt gggatgccca
41881 gacaggcgga tcacttgagg ccaggagttc aagaccagcc tgggcaacag agcaaaaccc
41941 catctctaca aaaaaaaaat gttaaaaatt agccaagtgt ggtgacatgt gcctgtagtt
42001 ccaggatcac ttaagaccag gaatttgagc catgatcaca cgaccacatt ccggcgtggg
42061 tgatggagtg agatcttatc tctaaaaaaa aaaataaaaa ttttaaaaat ttacatatga
42121 attagattaa gacagaattg tttaccaaat tccagaatat tataatatag gcttaggaca
42181 aataaaaaga agtataactt catacaaggt gaaatgcatg tattggtcta gggcatcata
42241 gagactaaat gcagatagat tgtaaaagat tatataaatg gcagactctt catagcttaa
42301 actaacccag agaattttaa aaactttcta aggctgaggt tgaggttaag gggtttagtg
42361 atgacatcta taatagagtc cttaatactg ctggaggcat agcacagggc tggatgaact 42421 gagcactata atttttttgt tgtttgcgtg acagagtcca aagaataaag ttgatattat
42481 agggttcttg gtaaagttca atactatagc taaacaacaa tgaaaaccca ttaaacatat
42541 attctcaggt aaaagttatt aaggccccac taaagtaaga aaatgaaaag gtgggaattc
42601 acgaagaaaa cttgcctgca tagtggtgac atttgtcaca gggtgccctt ctccccagct
42661 cagctctcca ttaccccttt ttaggtcaga gactgccaca ctcaagaaag gcctgagata
42721 ctctcagtca ctaacttgaa aacatcctat cttgattttt taaaatttaa gacataagat
42781 cataaacata aaagagatag agatatcaaa ttctaatgct catactaaat accagacccc
42841 caaaatatag aaatgatttt tactaaaata attctttgca cttaccggag aaaaggaaac
42901 agttgtattc tgatactgtg agtgtatttg gaaaataaga aaagtcacat tgcttgaaat
42961 atcatgcaaa atagcttcct ctggaaaggg cctattgagc tcgaagtatc taaatttccc
43021 cacagaaaat tcaataagac ctacaacgag ataaactttt cattacaaca cttgtactct
43081 catatcaatt tgcagaaatc atattcataa atgaatgtgg aatttaatcc tcagaaaaac
43141 tccttgaggt aaatatggtt attgctccta tttcactgct aaagacaatg tggcttaaaa
43201 agtgatgcag cccatccagg gtcatccagc cagtgaatgg tagagctcag aactaaaatg
43261 caagaggtat ttcaaaaggt atgctgaaga caggctcctg gaacccagag aaacttcccc
43321 tctggtagca gcaataacaa tgatctctgg aacagagtcc ctgaatttaa agatgacaat
43381 cctgtggggc tactaacaat catgaatgtg ctggtgttaa agaaccataa ccgtctagtg
43441 aattctgaag tcagcgtagc ccgaagagac acaggtggct gcaatttaat accggtgttt
43501 accagctgtg tgattttagg cacgttcctt aaatcccctt aagcctcaat ttcctcatct
43561 gtctaatgga gactgcaaag gaaggtgaaa tcaatactga caaaaatgtc caatgagcac
43621 ccacaccagg cactgcacat aaaattgtga accacaggca ttctggaaaa gagagctttt
43681 gtttgcttaa ggatcaaact gagtccataa aaaagatagg ttataacaag aacagttttt
43741 caacacctcc tccaggcctg tcccatctgt ctacttgcct ccatggtctg catctcactg
43801 actctgtccc cacttctctg tgatgtgttt ctgccagctg cacaccagct catctttttt
43861 caatctaact ctcaaataat cctttaatta ggttgctttt actcctgtgc ggtcctggat
43921 tcctacccca ccccccatcc tacagtcagt atctgtctgc atgaacagca gaaaagatcc
43981 caagtttcac ataagcagtc ttgggggttc aattctaaac aaacagacaa aagatttaga
44041 ttaaatatag atgaaaagga attgatgaaa aaagattata attcacccga gtcccatagt
44101 ggaactgtca tgttttattt tagaaggtaa ttagagtcag tgggcggtaa aacatttcag
44161 atactaaata acttaataac acattcttat ataccatgtc ccaaaaaggt caattttcaa
44221 cacttttttt tttaatacga aagctccact ggatgattta aaaccaaaca gaaccaaaaa
44281 aatcaagaat gagtagcctg tggaagaaca gccaaaaaaa agacacaaat agtgttaaga
44341 ctagaataat cttaacctct atatattttc cctaagctct gtgatgctac attacattca
44401 taacttaatg tttttttaaa aaaatgatag aataaaacgt tacaatttca tttctaaaac
44461 tctagagaaa attgtaatag ttttaacaat gacaaatgaa gatagcatat ttcctattta
44521 tggtaccaga aagacatttt acattttaaa tggaccaaac tccagctgga acagaggtta
44581 aaatattaag gaatggccaa tagaatctgg gtagggaagt ctggaaaaag tttgtgtgca
44641 cgtgtttttt ctttttaaaa agaaacaaga aaaacatgtt tatattttcc aggccttccc
44701 attatcatga ttattttatt agaaaagcaa attatacata aaactatatg gatttcagta
44761 aattacacta aaaatgtttc atttattgcc cttcaagttt ggtcccatcc atcatgcatc
44821 ctccaagtct taaaaattcc cacccgtatt ggcagtatca gtctgctttc ctagaaatta
44881 atcagatttc tatcctttca ctgttcacag cattcaactc acttactatc ctgccttttc
44941 tagtctacat cttcagtttt tcctttttgt tctcattttc cctatttggc aatatttata
45001 aggtactcat ggactaggca ctctagttgt tgggcaccat gatcaaaact gacacaaaca
45061 aattcataaa ggttatccaa ggcttctgta attatcactt aaatttgccc tttgatatta
45121 ttttagaaaa tgttctaata atcctcatgt ctatctccca tgacatgagc cttccatcag
45181 aacagtatac agaaccttta aaagccctgg aagagactga agccatcaac tagagaagcc
45241 ttcatggtaa acttttctta accttccctt aacctatcac ccaggatgag gatgaatcac
45301 aactcaaaaa tacttggaga aacaaaactt tggaaagaca gtacggaaac acagaaccat
45361 ggaaactaaa atacattgtt aaacaactga tgacttgaca aaataagtag gggggtatta
45421 aaagcaggta tctcttggag tatattttaa ctgatttttt tttttttttg agatggagtc
45481 tcactctgac acctaggtgg agtgcagtgg cgcaatctta gctcactgaa atttccacct
45541 ccaggttcaa gcaattctcc tgcctcaacc tcctgagtac ctgggattac aggcatgtgc
45601 caccacgcct ggctaatttt tgtattttta gtagagacgg ggtttcacta tgttggccag
45661 gctagtctcg aactcctgac ctcaagcgat ccgcccatct cagcctccca aagtgctggg
45721 attacaagca tgagctaccc tgcccggctg atttttcttt tttttacact tgtccttctt
45781 tttctttttc tttttttttt tttttttgag acagagtctt gctctgtcgc caggctggag
45841 tgcagtggcg caatcttagc tcactgaaat ctccacctcc aggttcaagc aattctcctg
45901 cctcaacctc ctgagtacct gggattacag gcatgtgcca ccacgctcgg ctaatttttt
45961 gtatttttag tagggactgg gtttcactat gttggccagg ctggtctcaa tctcttgacc
46021 tcgtgatccg cccacctggg cctcccaaag tgttgggatt acaagcatga gccaccacgc
46081 caggccaact ctacatttta aatgtttata aaataggaac acacactaga aaaaaaaagg
46141 gacaaaatgg gacattctct caacattctg tcactgtttt gctttccctt aaaatggtaa
46201 tatttttcta gaaaatatat aatccttata aaaggtgcta aataaacaga aagtcaactc
46261 ctccagcaag tacaatgtac agaaatcacc actgctaaca gttgggatat atcttttagg 46321 gcttaggcag atataagcat gcatatttcc gcatagatgg aaaaagatat aaatatgttt
46381 gatattgccc atttaacagg tcttatatat ctttccatag caacacagat aatgctagct
46441 ttaccatttt aaaagctaca gagtattcca ttctgggtat gtaccataat tattcaccca
46501 atctcctatt aatgaacatc taggctgtta ccattatagc atgaataata aattaataag
46561 aaataaaata gttctgattt tgtggaagac tattccagaa agcgtatgtg tcaggcaata
46621 aatctatttg agagagtttt tgctgtgaca gtgtaacaga tgacctttga ccttaaatgg
46681 ttaaactgta cctaaaaagt cttgttctag tctaagatat ccagaaataa aaacaaatag
46741 accatgtgag aatacacaat gattaggacc aaaaattaat ctgcagtctt tgcttctgaa
46801 ttcttcttca agaaatatac ctgaatttσa ggaataatta caactttcat ctgttatttc
46861 ctggatttcc caaaagctac aggaaaatga tgcctcatca tcttcctttc ctcaaatgcc
46921 tacagtgcga accaggcaga agccaggaaa taaaagggag ggacactgta tacattatgt
46981 aaaacctggt cacttgacaa aataggtagg ggtattaaga ggaagtatct ctgggggtgt
47041 attttaagtg attttttttc ttttcattac acatttcttt atttcttaaa tttctatagt
47101 gaccataagg tgtccttttc ataagaaatt ataatacagt gattatacac cctggctatc
47161 cattacaatc atctggaggg gattaaaaaa aaaacagaac actgctgcct gggaccctct
47221 ccagatgagt taaatcaaaa tccctggggc taaggtccag gtatcaatta aaaaacaaat
47281 atccattaaa tactatgcag agaaatacag aaagtttaca cacccatgaa ttaaccagca
47341 cctaaacagc attctagcat cttagtggtc cccctgtggc ccctcccaat cacatcttct
47401 ttcctcccca gagggaaata gggtcctaag ttcaaacact aggaatttat ttggacgaat
47461 tcaattgaat agaatttaca gcacaatttt tgtgtgtttg gcttctttaa aatcagcatt
47521 atgtttgtgc aattcattcc agctgctata ggtagctata actcattacc ataattgtat
47581 acttcatgaa ataacatgcc acaattatct gttctactgt taataaacat ctgtatttct
47641 ggtttagagt tataaataac tctaaacatt ttctgtgcat gtcttttggt acacgcatat
47701 acacattttt gttgggtgga acctgtgagt agaattatca ggtaataggg tattctcatc
47761 ttcagtagat actgccagtc ttccaacaat gttttgccaa tgtataccgc atcaacttac
47821 tgtaggaaag tgttccaatt gcccagaagt ctcaccaaca cctggtatca ttcatttatc
47881 tgctgagtat atagtggtat ctcattgtga ttttaattcg cacttcccta attactcatg
47941 ggtgttaaga aacctttgct ttgcttattt gctatttgga tatcctcttt gtgaaacagt
48001 ctgttcgagt cttttacaca tattaaaaat ggaactgtcc ttcttcaatt ttaggagttt
48061 ttaatacatc atagatatga gtattctgac agatacgttg cgaatatatt ctcccactct
48121 tgttgcttgt cttttcactc tgttaccttt agattaacag ttttcatttt agcagtcaat
48181 ttcaggtttt tcctttatga ttagtccctt ttgtgtcatt ttaaagaaat ctttgtcaac
48241 atataccaag atcatgaaga tacattccca tgttaacttc cagaagtttg ttttatcttt
48301 cacatttaga gctaaaaatc aagctgatgc tgatttttac acatggtgta agatagaggt
48361 cacagttcat tgtttcatat gttcatctac ttgacagcaa ccttcactaa aaataccacc
48421 ctgtagtacc ccatgttctc tcacttataa atgggagcta tgtaatgtgt acacatgggc
48481 ctacactgtg gactgataga cattgaagac tgaggaaggt gggagggggc ctgaagatga
48541 gaaattactt aatgagtaca atgtacataa ttccagtgat ggatacacta aaagccctga
48601 cttcactgca caatatatcc tgtacctaca cttgtgctcc ataagtttat acaaataaaa
48661 taatttaaaa ataccaccat ctccccaccc tactgctttg cagttccacc tttcacataa
48721 gtcaagtgaa catatgtgtt tgcttctaga gtctcaattg cattctactg gcttatttgt
48781 ctagctatag acaccaatcc taacacaaat attacaactc tcttaactcc tgctccaaat
48841 ttgttcttcc tcctcaaatt tatcttgact atttctgatc ctttacattt ccatataagt
48901 tttagaaatc agcctgtcaa tatccacaca cacacaaaaa aacctgctgg gattttgatt
48961 gggatggccc tgaatatata cattaattta ggaagaaatg atacctttaa aatatcttta
49021 tctttagaat tttgtaatct atgaatttcc gatattcctc tatttcttta gtttctcaat
49081 ttatctaaag aatgttgaga tgtattatgt tattttctct gtagaggtct ttacatatcc
49141 catgattatc atcccagaat acgtaatgtt tcttgaggct attttaaatg tactttttct
49201 tttctttaat tttatttctt aacgttttgt agagatgagg tcttgctata ttgatcagac
49261 tggtcttgaa ctcttggccc caagagatcc tcccccactc agtcttccaa agtgctggga
49321 ttacagacgg aaccacagca cccgaccctg ctttttcttt taaatgtcta tttctagctg
49381 tctcttcacc aatatatctt ttataaaaag ttctccatgt aattctaatg tttagctggg
49441 tttgagaact cctaacatag tgtttgataa acaagcaaag gataaatatg tatttttttc
49501 ccagtcttag ttatctctaa cctaacatct gtgtgaaaat actttggcag tgtaaccctg
49561 gcaatctaac atccattgta caattttttt cagaagattg ctttaaccaa accagttgtg
49621 gtttgattcc tggctgtgca ggattttgtc atttttgatg ttccaacgtc taacacagta
4g681 tagtcaccta actggcatac agtaaatgtt tgttaaatga tgcctgaact atgtgacctc
49741 aggcaagtaa tgtacttcct ctgggcttca gttccctcaa agtaaaattg aggtaactgt
49801 gctgccatca gttggctgct gaaagtatca aacaaatggg aaacaacttt taaactgccc
49861 aaggctacac aataaagcat catttattaa tttccattag ctttcctgtg cttcacacat
49921 tcatctcctt attgaaagaa aagaaagaaa gaaagacaat caggcactca gagcagccct
49g81 acgaaaaaat tagtgggaag aaaggaacta acatgtacag ggcattcaca gaaattccag
50041 gcacatcata agcattacgY tgagaaagag acttccgaag agtgacaaca aaagatactg
50101 aaagtcaaga caacttaaac agctcagtσt ggtagaaact catttaattt ctgctcataa
50161 aaacagattt agcaaaagaa gacacatact caaaaaatat cctgaagaag ctaacaggaa 50221 tttaacttca cctctaaggc atatggaaaa ggattta-tta gaagcatttt atgaggcata
50281 attatatctt atgacttgca gagtaggagg aaaaaagaca gcacatcaaa agatattaca
50341 aagcaaatgg ctaacatcaa gttggggcac ttacattagc tttcctctaa aaagaaatgg
50401 ctttttttgc catctgacct atagtaggga cttgaaacaa tttttcacac ccatcttcca
50461 ttcttaccca gaatcacttt ttctttccaa taattccact ttaaaaagag ctgcccaatc
50521 ctaatacttt cctttttctt tccgaatcag atcctaatct ggcaaccata aaaatttcca
50581 actcttcctt tttactattt tactaaaatt tacttctact gtttgtgttt caacacaaca
50641 accaaattct aagagaaatc catcatagcc tagtcttcat aattctcttc acattaaaaa
50701 caaaaatggt tcagctactt gagttggtca gcagtcaacc gcccctccca atttctcatt
50761 gttatcttct tacaaatgtt caatagccct aaaggttgaa agggaacaca aaaatgaaca
50821 tattagcttc acacactttt tagagaaaga cagcacttgc aactaaccat gaacagcctg
50881 ctaccttggt aaagcatcat caatagcaag aagactgaaa ggcccaaatg atgctgtgct
50941 caagtccaat tactatgaaa ttccacggga gttactggat atgaatctaa acaaatgaaa
51001 gatgttaaag gcagcagtga actgggactc caagagaagg gaaaactgct taaaagtatg
51061 atccatctca tgtgcctact ggtcacagaa agcaccctcc tcagacattc taggaactcc
51121 atctgccacg ttccaagatt tatttagcat tcaggccact acagaagtca tgcaagttag
51181 ctcatcctgc caaagatggg taaatcctcc taaattacag cagatgctca atttcttcag
51241 tttgtatggt tatcagaatt atcatcatca aacatcaatc cagccatttt ctaggaggat
51301 tatgcaagtc ctgaactatg tccttctacc tttctatact gatttttagc tgatagatgt
51361 ggagaatatc agcttttatt atcactcagc agttaagtcc ccacattgtc cctcttctgc
51421 acagaatgac aataccaatg caaggcaaaa agaataacat tgaggaatat cagtgctata
51481 atcatagcaa agaggcaaaa agcagtgtct gaaaaaaatt aatttctcaa tttattcata
51541 ttttttaact tttgtataaa aatttctagg tattaaatac taacaccaag tagaaagaaa
51601 aagttctgga cgcctgctct cctgactcag gggctggcct cgatcaacta aaaactctaa
51661 tatctcaaat tcttcacctg ttaaaataga gatagcatct cttctacctc catcataagg
51721 ctattttgaa gaatgaggat tcacagaagg attaagtaca aagcaccatg ccatgtaaga
51781 tattcttatt ggaagacagc tttacggaag tggaaggact atgaaatttg cagggagact
51841 cacctgggtt caagtcctat ctgtaaccct agcagctgtt catttgttcc tctgacaagg
51901 gaggaagatc attacattgt agggtggtgg ggattaaata acactgcacg tggaaagcac
51961 ctggcacaca ctatacagag tgaatgttag tgccctatta taagcaaggt ttttctgcaa
52021 aaaaaaaagt tgcccttttc agctttggcc tcagtcctat atacaaagat cctagaattc
52081 agtttgcaca agggcttttc aaagataagt gcatagcaac acaatcacat tattcagaaa
52141 atattatgtt tcagaactgc aactagtcta ttaacctcaa aacaaaacag aatgtgctta
52201 gtttcatgga aaagcacatg atgatctgcc tggcacaact agtgcctttt acattttata
52261 ttaacaaacc atgagctgtt gcccaaaccc attcaccaag cacaagactt acaatctaac
52321 atcccattct gagttctcac tgagatgaac aagaattacc tgaaatcggc cgggcgcggt
52381 ggctcatgcc tgtaatccca gcactctggg aggccaaggc gggcagatca cgaggtcagg
52441 agttcgagac cagcctgaac aacatggtga aaccccgcct gtactaaaaa tacaaaaact
52501 agctgggtgt ggtggcgggc gcctgtaatc ccagctactc tggaggctga ggcaggagaa
52561 ttgcttgaac ccgggtgtcg gaggttgcag tcagcc-aaga tcatgccact gcactccagc
52621 ctaggcgaca gagcgagact ccgtcaaaaa aaaaaaaaaa aaaagtcacc tgaaatcatc
52681 aaaaatggtg tactcatagg gagccaagcc cgggcatgtt gcttcttggc tcccacaggt
52741 gaatttgaag tggcaataga acttcgttga ttcttgtttt tctcatttta gttttactct
52801 ctattaaatt gttatttttt acagttcatt tatggatgac aagttatttc ctgttggtag
52861 ctgcaatgat tgggaatttt gtgatctctg taaacgaatt aatatctcat agagatctat
52921 ttcctgttgg atatgagaca acagagaaca cagtttttgt ccatttgtct tttttaaggt
52981 caaatcgatt agaaatttct tgccctcaag taaggagaac aactctgata cctggactgg
53041 caagcttttg tgtttctgtg tttatttttc atttgtggct gaacttgtag aattgagggt
53101 atacacattc tatctgtatg tctatgtatc tgtaattcag aaagtccttt atttctcatt
53161 gtgagtatgg aatgttttcc tgtctccaga tggtattaat aaattagatg gtaaaggctc
53221 tttaaaaata aagcctcatt atgggttcat tttccctctc aaactctgta gaacataacc
53281 agtttgaaaa gYctctagat ttgggggtgt aaaaattcca tgcagcttga gagccatcag
53341 tcattaagcc gctagttcca ccccaagtct tgctgtccag aagctcagac agYccactgg
53401 gcagcaaaga ggcgctttag taagttgaat taaagccaca aacatggctg ctccctaagg
53461 gagataatac tgtgttaaaa aaagagaatt atttatctct tcccatttcc tccgctaaat
53521 gaggaggtta atagtaagac ctccttagcc atgagtgttt ccgctgcagg aaacaccatt
53581 cgtgccggtt ctggactcac cacccagcgt gtaccaeacgc ccccagcacc atctccctgc
53641 taggctgaca gacccctggc ggattttgac ctcgcaagaa atgcaaaagc aactttgggt
53701 tgcagaagcc aggcgccccg accttaccct cgctggaatt cccgaagacc tcggctgcac
53761 cagccacccg gtgttcggat gccagcaccg ctacgaccag cagctgcagg aaccccattg
53821 ctgcctgggc cgggctgggc ccacgccagg gctggggaga ggtgcgggcg tgcgcgccgg
53881 ggccccgcag cctcgcccac gctatcccgg ggcgcccgca tcgggcgcca tcgcccgcca
53941 ggtgcagacg cttcgcacct gccagctccg cagccgccgg cgcgcgcccc gccgaactcc
54001 tagccccagc gagaggtttc ctcttccggc acctgacccc caacgcgcgt tcccgcgcct
54061 cctcccgggc tctcgctgcg tcacagcggc gggtctctgg gcgcgggcgg cgctggggcg 54121 tttccaggca gcgcgcgcct cctgccggcg cgcggggaac gcgcagcctg cggtgctccc
54181 gggagccccc aggaagtcct ggcttgaggc ccggtcttgc cccactttta tctcaccaag
54241 taggcaaacc cactgtgaaa gtacaaaata actttctgtt gcggactaac gtcgccaggc
54301 tcctgtttcc gtgtttaacg gccctttaca acagcaaaaa agaggaatca gttgctaaaa
54361 acacaattga aggttatttc ccccggtagc aattgtcttc gctgctgagg cttatgttag
54421 cataaaaatg ccaggagaat gctgtttgtg tagtggttac cgcactagtc ataagcacta
54481 catttaaaag tagtttcgtt ttctctaagc gaaa-tatcct cgaagacacg gccttggtct
54541 gaacttcgtc tcaagtctca tacctgagtg ctgtttgagg gacagtagtc catgtgacag
54601 atggctcatc gatgatgtgg aattagacgc atagacttaa cgttatttgg ggaggattgt
54661 cttgctttcc ttccctggtt ttaatttttt tcacttatat attttgatga gcaacttata
54721 gcttggaaat tacatgttca gttagtccac tactaagcta acaatatata gctgtgacca
54781 taatgtgaag aagtgttaaa gacaaaatta ttcaatgata cttgttaaag caccgaacga
54841 agactattga ggactgtctc aattggcata gggaccactg caactgggtc ttgcagtggg
54901 gaagagggac tgggctcaac tccgaataca gcgtgggcaa gagggaattt atagccaacc
54961 agcagtatgg agttcagtgg atggaaaatt actaagagga agcatcagag gtaaggggca
55021 tttggtgaaa ctgacctaac aggacttctg aagacataac atcacctggg ggatggtgca
55081 gggtgagaaa actgattaga tatggaggaa agggggttct ttgctaaaac tggattttta
55141 caaagaagtg cacagatgga cctagcagaa gattcagaag ccgtactaga gtttggccaa
55201 gcaaataatc tttgtcatag gcacaattct ttctctgctt tcccactgcc tggtccaaat
55261 tttcacacct ttggtagcac tatctatttc tgtagtgctt attcactctc ccacatgccc
55321 ctattcctat aaccctcagt agatgaaatc caaggaagat gaaagggaca attatgataa
55381 gggtagcatc tgaatcagtg gatggattat tcaataaatt gtgttcttaa ctgattagct
55441 gcactatggg cagagagaag cagaactcta tctcacacta attgtgaaaa caaaatccca
55501 aagtaataaa accataaaag agctagcaga agagggcgct cttttttttt tttaataaat
55561 tgatctcaaa atgggaggag ctttctaaga agcaaaacag caaaggaaac aaccataaag
55621 gaaaagattg gtagacttgg ctacgtaaat gctttttaca taaatattta aattttatta
55681 aagtaaacac acaaacaata tgaaaaggca agttgaccaa aaaaaaaaaa ttagcaaagg
55741 acatgaatgg ggaatttcac cccaaaaaag aaatacaaat taccagtaaa tacatgaaaa
55801 aagttcaatc tcactagtaa acaaataaaa aaatcaaatt aacaaactaa gatgtaaaca
55861 ttttaaaagt ataaaacatc cagtgtggat aaaagagcta agaaggaggc attcttaggt
55921 agggatactg ggaatataca ctttaataaa gtaatcggca tcaaaaatgt ttaaaaatct
55981 tatttttgta gatttggtat aatccacttt tagatttaag tacataatta aatacacata
56041 taaaaattag tataagctgg gggaagtggt atgcgcctgt agtcccagat actcaggggg
56101 ctgaggcagg aggattactt gagcccagga gttcaagagg gcagtgctgt atgattgcac
56161 ctgtgaatag ccactgccct ccagcctggg caacatagtg agaccccatc tcttaaaaaa
56221 aaatagtgta cagaactatt catagagtat tatttagagt agcagaaaca tctaaaacaa
56281 cctaaatgcc caacaattag gagttaaata acctatgata gagctttata agaggatcct
56341 gtgcagccct tcatttatat tctgattgaa gtctttatga aaaggcaagt tatgatgcaa
56401 taagtatata tagtacRtgg cttttttttt ttttNaacat acatctttta ttgactcaga
56461 ggaatggata cttttgttgt ttgtttgttt ttttaaatgg agtcttgttc tgtcccccag
56521 gctagagtgc agtggtgcaa tcttggctca ctgcaacctc tgcctcccgg gttcaagcaa
56581 ttctcctgcc tccgcctccc aagtagctgg gattacaggc acacaccacc atgcccggct
56641 aatttttgta ttttttttta gtagagatgg ggtttcacca cgttggccag gctggtttgg
56701 aaatcctgac cttgtgatct gcccacctcg gcctcctgaa gtgctgggat tacaggcgtg
56761 agccaccaca cccggcctgt aatttttttt taagagacaa gatctcacta tgttacccag
56821 gctggcctta aactcccaga tgtaagaatt aaagaagaaa gaaacaggaa aggtggctta
56881 gaagtcaagg acaagtttat tttagagaaa acaaacctga aaggggcttc tggccagtta
56941 ggttagaggc acactctctt acggactaat aagagttttt aaggatttag ggtgggagag
57001 tttatcagag gcttggactg cttctgtgtc tgttgtgctt atctgggagg gagagttgtg
57061 tgtctgttcc catacatctt tttgcagctg caggcatacc cccgagtctg cttttagctt
57121 ccctatctta gtgcacctga agggaaagga atgtacttac taaggcccac tgttttactg
57181 gggcccattg tatgagggtg aagtttggca gttacccaag agaatttccc cccacctccc
57241 tttgtgcctg agctgtctta tctgtgtttt actgtctgct ctttctggct gcttatagtt
57301 agaagagaag tgatttcctt gaaatgcatg aggctagaaa gggagctgga acttaaagtg
57361 gcggtgtttg tccgagatga cggtgctcct ggtctgtcac cagactcaag caatcctgcc
57421 acctcagcct ccagactaac tgggactact acaggctcac accactgtgc ctgccttgtt
57481 ttctttgtag tatgcattcc tggttatgta catagaaaaa aaggttgaaa aatatatgcc
57541 aaaatgttta aaatagttat ctttaggtgg ttaaattaag aatgatttcc tttgcacatt
57601 tctgtgtaaa agttctacat tgaagtgtat catttttaaa taagaaatta tgattttgta
57661 aaagatacat ataattttaa aggttttctt ataaaagcat tcaagatata agtccacctt
57721 cctgagtatg acacataaat gctttttgtg atgcaactcc tgctcacctc cctaggttct
57781 tgctgcaact aaaatcagac ctctacatgc tggccacatt gaattaattt caatttcctg
57841 aactgagcct attctctctc ctccatacct ttgcatcgca gttccccagg cctgcagttg
57901 cctgtgcatg catgacagtt gatgacaaat gtgtcagcaa tcagaacagg gcctcattac
57961 cttggcttct aagtacagta ttgtgacagc ttgggaggat gattggctgg ggttccatgc 58021 tcatgtcaga gttccattgg agagctgaga agcaaacaag cttagcagct ttgcagatta
58081 gttcattttt cctatgtatt gaaaggaaat gcagaaactg aaagattccc aaatccaaga
58141 tatgcatcat tagaggctta aagtctgttt aggccaggcg cagtggctca tacctgtaat
58201 cccagtactt tagcagacca aggcaggagg atctctggag accaggagtt caagatcagc
58261 ccaggcaaca tagtgagatc cccattctta cacacacaca tscacacaca cacacacaca
58321 accagaaaaa aaaattagct gggcatggtg gggcacatct gtagtcctag atacacaggt
58381 ggctgaggct ggagaattgt tcgagcctag gagtttgagt ttgcagcgag ccatgattat
58441 gccactgtac tccagcctgg gtgacagagc aagaccctgt atctaataaa acaaaagtct
58501 gttaaaattt agaagaggaa ggaagggcag gagggagaga aggaggaagg gaaaaaactt
58561 accctagctt tttaaataaa acctaaaata ccttaaatgg agctgggagt ggggatccag
58621 ggaaaaggca ggattgaacc tctgtgaaat ttgcccattc attctttccc actctaatct
58681 caccttcatc ctgtattttt taattcttat gctcttttgt gggtagtaat ttacattctt
58741 tgttcattaa gttaaattca gtaaatgctt gtttagtagc tattatatgg aaattattat
58801 gctaggaaac tcattcattt ggttgataaa tatgtgccag gctaaaWgtt aggtgctagg
58861 tactggaaat atggaaacag aatatgtttt ctgcctgcaa gtagcccatg gactggtggg
58921 tgaattagcg tgatgtacaa ataattacag cacagtatgc taagtgcaat aacagaagtg
58g81 taaggaacaa ttgtgttaaa gattgggagc atttaacttt csgaattcag gaaaggcttt
59041 tataaagaga tgtttaaaat aagattttgt tcactagtat agtggcaagt aaaaaaaata
59101 ataataggcc gggcacagtg gctgacgcct gtaattctag cactttggga ggccaaggcg
59161 ggtggatcac ctgaggtcag gagttcaaga ccagcctggc caacatagca aaaccccgtc
59221 tctacacaaa tacaaaaaac ttacccaggt gtggtggcgg gcacctgtaa tcccagctac
59281 tctggaggct gaggtaggag aatcactaga accctggggg cagaggttgc agtgagctga
59341 gatcgtgcca ctgcattcca gcctgggtaa cagagtgaga ttctgtctca aataaataaa
59401 taaataataa aataaggttt gagtactgtg tggacaatca ccaagggagc aaagtggaga
59461 tgtggatgga agtgtaggca tttcatacaa ggaagaaata attataggtg tttttatatg
59521 gtgtgcattt ttgtaaaaca gcagaacatg tttagggaat ttcaaagagt gtggtataga
59581 aaaatgctta tttaYagtta ttcatcccgg cactaagaac agtttagata tttaataaat
59641 tgcaactgtg agtattaaag Ktatttaaaa attgctaaag gtgtttttct taaaaaatag
59701 ttgctacagt cataaaaacc aaagcattta caagattgac tgjagtggctc actgctgaag
59761 ctgtaaaggg tatgcgaggg ttcactatac tgtctacttt tctatatctt tgaaactttt
59821 aataatataa agtttcaaag aaagtactca ccaaaattgt gtgtttaaaa tatgagatct
59881 gtaatactgg gttcctgctc ctaaaaccat ataatccagt tggcgatgca acagaagcaa
5g941 atggaaaagc atatgagaaa gtgtccaaat catgaaagga agaaaggaga ggtccctatg
60001 gactctagca attcataaaa tttatatgag aagtgtacag cttaaaaagg tagggtaagg
60061 attaaatagc aggaaagaaa ttgctttggg aaaggtaaag astgaggaaa gagctagacc
60121 agtggttctc aattgggggc aattttgccc cccagcaaca tttgggacta tctggagata
60181 ctttatgttg gcataaatgg attgggggga tgctaccggc a ctcagggg taagggacag
60241 ggatgctcta aacatcctac agtgcacagg tcagcatccc acagcaaaga ataatctagc
60301 ctgaaaagtc aagagtgcag ccattgagaa atcctgagct agatgcacag actaYatttg
60361 gcaggtgggt tattcttgaa gtctacagct tcaagagctt cctaaaMccc ttttcaaatg
60421 taggctaagt tgagagtctg gtctggggaa agggtccaca gcttttatct gattcttaaa
60481 aagatccgtg gccgaaagag gctgaagaac caggaaaacc aaggggtcag ggaccttggc
60541 tgaaacagat tatttcactc agaaaattat caggaggtga ggctgggtct gtttgctgga
60601 gccagattat agtaaatctt gaaaaccagg cagagatagt tggacatcaa cctgaggtct
60661 ctgtggaggc acagaagacc tattaggaag ataatggcag gscaaaaact gtgtcacaat
60721 atgaatgtct tgaagtggct tctctacttc aactgcccaa gttcccttca atcaggctgc
60781 aaaacttagt attcttatgg agtggactaa actatatcca atcagtcacc aatccatatt
60841 aatttttttt ctcaaaaata tattttagtc tttctttccc cgcttatcag ggtcaacacc
60901 ctattctagg cccagctcat cttaatcttg gacaactgca asaaccttcct tagtgagtcc
60961 ttggcttatt catctttgca aattgagcac tggatatact tcctggcatg tggcagccat
61021 tccgtaaggt acactctcaa gtgagggtgg gaggagaagg ttgtagaatc cccccaagtt
61081 acagtgaaaa caaattacag agtgatttct cattagtccc attatgggga acatgcctca
61141 tccacgttct taatgaggct ccagtaagtc tgtagactgt ttggggctga gggtggggca
61201 ttggtgtgaa gcagaagtgg tgcttcacag taagtgttgg gataaatcca acaagctgag
61261 ttccccaggg actgtgtctt ccaccttccc cgcagccaca ggaaggtaat cacggataat
61321 cagcctgaga aagaggatat gagagttttt tgaagtctac aaacctgtta tttgccgatt
61381 ccaaactcat ttcttaccag actatcctca ggctaaattt ccttaaatac caagtttcga
61441 ttatcacttt tcacacttaa actctcaata agtcccaact ctaaatctaa attgtgcagc
61501 taatttttct tggccgagca cggtggctca cgcctgtaat cccagcactt tgagaggccg
61561 aggcgggcgg agcacgaggt cgggagatcg agaccatcct ggctaacatg gtgaaacccc
61621 gtctctacta aaagtacaaa aaaaaaaaaa aaatgccggg cgtggtgcgg acgcctgtag
61681 tcccagctac tccggaggct gaggcaggag aatggcgtga acccgggagg cggagctggc
61741 agtgagccga gatcgcacca ctgcactcca gcctgggcga cagaacgaga ctccgtctca
61801 aataaataaa taaataaata aataaataaa taaaaataaa tatatttact cttcaatttg
61861 gtcaataaat aaacacgaga gggtacgaga aattacttaa aaaaaaaaaa tccccgcaga 61921 atccaacaat ctctgaagcc tttaacacct aacaacccca aggggagtat ttcggctctt
61981 ggactgtatt tcaaagcgat tggaccccag accattcccc cagttactca aaagatccag
62041 cctctcctca ggtgtagccc gctctagaaa ggccgcctcg ggagtaccac ccactcctga
62101 cggggcgggg agttctctcc gaccccaccc gttccaagga cgcagccctg tgattggcca
62161 tgacgcgtgc cagagctgcc cagtcgcgga agagcagctg ttttggcgtc tgtttgctgc
62221 ggtaggaaca tggcggatcg gctcacgcag cttcaggacg ctgtgaattc ggtgaggaat
62281 ttcattcgat tagcctctgt ctttctcttt cttgaggtaa agcaagggag gaaaggggcc
62341 caagaggcaa aacttgRaag tggggagcgg actgagagac agggcttcgg cataaagcgc
62401 tctctcggga ggcgccaccg cgaactcgga ggtttgaggc cggctgccgg gcggtgcttg
62461 aaggtgcggg agggagcaga ctctttcgct tgaggagacc gggaagatcg ttcttgtccg
62521 ggtgaggccg ccaggacttg tgggctgcgc ggtcctgtcg tgttccctga ggacagtttt
62581 attttcttgt cagtggtgct tacgggttct ctttcttttg ggggttggga ggagaagcag
62641 gagctttttt ctttcctcat caattttaat ccaccaaggg agatctcatg ctctggatga
62701 ctgggttttt gtaatgaaat gtcagccgag agtattcctt caccagcgct ttcaggttgg
62761 tgcgggagcg atgctgaggt gaggtgagag attttctttc atcttagctc gttcctttgg
62821 gcccagagta tccttccatc tcttgcctct tggccatccc tcagaataca tcagtttggg
62881 gacatcttta tgataggaaa tcttctaatc ctcgtatgtc tttccgctta tttgagtctt
62941 ttttcttttc tttttttttt tttttttact ttggagacag tgcctttcgc ccaggctgga
63001 gtgcagtggc gcgatctctg ctcactgcat cctccgcctc ccgggttcaa gcgattctcc
63061 tgtctgagcc aaagtagctg ggattacagg cgccctccac cacgcccggc taatgtttgt
63121 atttttagta gagacggggt ttcaccatgt tgtccaggct ggtctcaaac tcccggcctc
63181 aagcgatcct cccgcctcgg cctcccatag tgctgggatt acaggtgtga gccaccgtgc
63241 ccggcctaca agtccttttt aatgtctccc ccaaattcta ctctctatta aaggccaagt
63301 ctagtaagta gctccccagc tttgttcctt ctggttattt ttcctccaca ctatgcctga
63361 gtggaaagta gaagcaaagc cagaggatgc gcagtcatgg gcccctaatg aaggggtcat
63421 gttctgagaa atgcatggtt ttggcgataa cttttttttt tgttttaata agtagaagta
63481 caatgtaaaa taacgataaa acagtaatac ataaaccagt aacaaagtca tttagtatca
63541 ttatcaagtg tcatggactg cacataattg tatgtgctat gctttcatac actggcagtg
63601 tggtaggttg atttacagca gcatcaccac aagcactaag gaacgcattg cgctacagcg
63661 ttagtactgc tacgatgtca ctaggcaata agaatttttc agctttatta taaccatagg
63721 ggactgacat aatatgtgca tcccgttgac caagacgtca gtgggtattc ccatgcggca
63781 atgggtgtac ttattaccat tacgagttag attgttttct gctaaatagt tttccattga
63841 tagttatgtt tctcattgtc tgattgtgat ttaatgtcct agataagggg ctagagagaa
63901 aacatgctga taggaaaacc taagtacctg gtttccttgc cagttttttt tttcctcact
63961 gtaagctaat aacttggcat ttttcttaat acatcagaat ttgtacactt gaagagtgtg
64021 aatctacttg tgataaaact gatctaccct gggtgaataa cactagtttt taagctgaga
64081 ggaccagcct ctaagtgttg aattcaccaa gataaattct accctgcagg gacttgcctg
64141 ggctgccagc cagccttcct cagggaacta ctcctttgag gttttacgaa atcaaattgt
64201 aatgatgctg ctggatagaa atcttatttt agggaaaatt ttgcatattc atacatgtct
64261 tgtaactaga aggataataa ggacagagtg aatatggcct taactccagg ttaggcataa
64321 tgataattgg attttggaga aaagccttta ggataactag tatgagtgcc tactgtgtgt
64381 aagcaccatc atgtttacaa agagatactc ctaaaggagg ttaaaaaatg tcaaatactc
64441 aggagacatt taagtgatgg aaaaacagta tgtggttagg gagttataat gaattgagta
64501 ttttcagctt caggttctga tgtaaattgg aatatggagt gatgtgaacc aaaatagggg
64561 gaatcttctt agcatttatc ctaatcagaa ttatttgtat aacttttaac atttgttcta
64621 ccctctgaaa accgtgagtg cagaagctat gtcgcattca ctatgtctct gtagtgttta
64681 tatgcagtac tttagttatt ttccataaat ttttgttgac taaatggatc ttaaaagctt
64741 ttgaaggatg gaaaagatag acactgtgtt gaatattttt ttgtgtgtgt ttcctctatt
64801 acaacaatgc tataatagga gaatgtatcc aatttaaaaa tgaaaaatgc tgcttggatt
64861 aatagagcta ggatcaggat ctaggtttgt atagcatctg agcacttatt gctccattac
64921 aattagcaaa acctgggcaa agccatttag tcataagtga ctttatgact agttagataa
64981 atatgaagga gtagtggaaa acgagtcagt agagttgact tagattattg aaagcttcaa
65041 aacagcctga gttggagatt tatcttgaag acagtggtgg agtaagctta aatgttttga
65101 tcaggttaaa ataaataacc tggtgaactg gaaaacaaca agaagactat tgtaataatt
65161 ctggtgtgag ataattggtt gaactaagca acagtgatag aaggaaaaga gaaagatttg
65221 tagtattagc agaatatgaa gatcaaagga aagtaagaat ctgaagttag attggttgac
65281 taggagactt tcaatacaaa ttaaatatta aaaagaggaa acagttgcct ttgagttctg
65341 tcattgaaac aatggcagag aaacccagtg gaaatactta ttagaaatag gaggtttgag
65401 aggtcaagac taggtgagag aaattggtag ggaagatagg tgtatttaat ttggagatgg
65461 taaggaattg ctattcccaa tctttaaaag tacttaagga a acttttag agtacaagag
65521 tttacaaatt gagtcttgaa caaatacatt tctgcttact taaggtgctt ttctgagcag
65581 cctcttcctc actatttctt tacacttgta actactccag tctcagaaaa ggaatcatat
65641 actttgtgca tgagaaataa atttttatta aacatggtgc catagatatt tacaagtcaa
65701 atttgctctt ttccatcact atccccaaaa agtctttact tgtggcttac aataagtatt
65761 ggccaatatt ctcttatcat tttactatca caagaaaaga aagattattt tgtatttcaa 65821 ctgtttcaac tagatttata tcaaatttaa ctttacctag attgatacca aacttagttt
65881 ctttgcagaa ttaaaacgtt taatcaacat taataataac tggcttattt tatcaacaat
65941 cactcctttc tgttttattc ccttgctcag agattatcat tacagaaact tattgttgtt
66001 gccattacca ataaagtcct taaaactgat aagtcctttc taaccttgat atgttttctt
66061 tggcctaagc ttgcagatca gttttgtaat gccattggag tattgcagca atgtggtcct
66121 cctgcctctt tcaataatat tcagacagca attaacaaag accagccagc taaccctaca
66181 gaaggtaaac aggttttctt agcttctctt agtttgactc tcacattttt tgtaatcctt
66241 taaaattaga tttcttgaga aattcagctt attttatttc taaaattatt gttgtttgag
66301 aatattacaa gttttgtttg ttgtaaaaaa tttacagtca attcacctaa catctcataa
66361 ttctggttca tgtcagataa tagattgtta ctcctttaga ggagaatttg tattaattta
66421 gctgagtgag ggaccttaac aaggaaggσa tcccatttat aaatttcttt attcaggtga
66481 ccactatatt gtcataataa atgaaattac atacattatg cttaattccc aatttgagct
66541 aaatgtgtaa caggattggt gtatatttta atcattagaa tcttcttttt ttttttgaga
66601 cggagtctcg ctctgtcacc taggctggag tgcagtgatg caatcttggc tcactgcaac
66661 tttcgcctcc cgggttcaag gaattctcct gcctcagcct cctgagtagc tgggattaca
66721 ggctcatgcc accacgtctg gctaattttt gtatttttag tagagatggg gtttcaccat
66781 gttggtcagg ctggtctcaa actcctgacc tcgtgatccg cctgccttgg cctcccaaag
66841 tgctgggatt acaggcgtga gccaccacgc ctggccgaat cattagaatc ttagggcaga
66901 aaaagctata tgaagtttct ggtttcatta acttaaaatt tgtttctgaa aacttgaggt
66961 tttctaatat cctaatctag cagtatcttt ctctagagta tgcccagctt tttgcagcac
67021 tgattgcacg aacagcaaaa gacattgatg ttttgataga ttccttaccc agtgaagaat
67081 ctacagctgc tttacaggta agcctctatt cctttgagaa ttttaccagt aatagagaat
67141 tttgaattaa aggaggtaga tttagtacct tttgtctgtg tccatttgtg ctgctataac
67201 aacatacctg agacagtaat ttataaagaa cagaaattta ttttctcaca gttctggagt
67261 ctgggaagtc caagatcaag gcatttatta ctcactgtgc atgagtaatg aatttttatt
67321 aaacatggtg ccatgtttag ggccatgttg agggccttct tcctgtttcc tcacatggct
67381 gaaggcagaa gggcaaaaga gcaagagctc cctcttcaac ctcaagccat attttaaggg
67441 tactaattcc atctatgaga tctctgcctt catgacttaa tatcctctta aaggcccctt
67501 ccctcttaat accatcacat tggggattag attttaatgt atgaattttg gaggggatgc
67561 attcaaatca tagcaccttt tgttataata ttcaaatttc cattataagg aaacctctta
67621 ttttcctcaa ttttgtctct tttcctagtg aagaatgaga ggagggtggc attctacaat
67681 tggagtagaa taatggtgtc taaacgtaat gtgtaaggga gtcacttaaa gatatctaga
67741 gatctctaat tgaaaagtca ttctttttaa taattcacat ggggaaaatt cttaaaagtt
67801 gtctgatttt tagaatttct ttactgaaaa acatatcaca atgattgcaa agtcatccag
67861 atttaaaaat aagtacatct gtgacagctt ctctttctaa actctaaaga ttttaaaatt
67921 tgtgtcttat aaaggctgct agcttgtata agctagaaga agaaaaccat gaagctgcta
67981 catgtctgga ggatgttgtt tatcgaggag acatgcttct ggagaagata caaagcgcac
68041 ttgctgatat tgcacagtca cagctgaaga caagaagtgg tacccatagc cagtctcttc
68101 cagactcata gcatcagtgg ataccatgtg gctgagaaaa gaactgtttg agtgccatta
68161 agaattctgc atcagactta gatacaagcc ttaccaacaa ttacagaaac attaaacact
68221 atgacacatK acctttttag ctatttttaa tagtcttcta ttttcactct tgataagctt
68281 ataaaatcat gattgaatca gctttaaagc atcataccat cattttttaa ctgagtgaaa
68341 ttattaaggc atgtaataca ttaatgaaca taatataagg aaacatatgt aaaattctgt
68401 tatgacataa tttatgtctc cattttgttg tattggccag tacttttaca aatcaaaaca
68461 tctctcaagc caaaggagaa gacagtaaga acagacataa gggacatttt agtttRggct
68521 agtgtcctgc ctcttagagg tggcattgtg taaatctgag ctttgagcaa gaaagttttg
68581 gaaattgtgt tgcttttaag aaatagagtt agtgtggctg gataagaaag tcacatttat
68641 gcaaatgttt cttctgctag aacctcatac ctgttctagt tcatctccac gtttatttta
68701 ccaagagatc ctctgtcaag agaatttcct ggctgttgtg aaagaatttt tctacatcct
68761 gaactatttt tcctatttct tttcaccttg ctttttttca tccttaattt gcttgtcatc
68821 acaatgaagt atgttttttg aatcatcaat tctttctcat tctccattta tctgaaggtt
68881 cttttgccct tattaacctc tcaactttta ttgctgtatt ctagtcagac cagaacatac
68941 ttccactaca tcagttactt ggcatcattt cacctcagtt tattattgcc aaataataat
69001 ttgtgtcagc attttcaact atggttattc atccaaccct tggatctctt tgagYctact
69061 gataatctcc actggaaagg tggaattgaa atgtggtcca cattttaact agctatttcc
69121 tggggctgta tttttcagaa tatgctgagc tacatttgct gcaatctgtt gctattcaga
69181 gtttaagttt caggagaaaa caggaacaat agaacactct gcctgttatt tttgttgtaa
69241 tcaagctttt ccacagttct tgaaaagtac tatgtttcaa atttcaggaa caccagcgtt
69301 agctgtaaaa gttgcagcaa tttattggct agtcatagaa aatttttgaa cttttaactg
69361 tattttaatt gatgtttatt aaaaacactt tgctatcaga tatttggcat aaatctgtac
69421 tcttcattat agttttgggg ggagagaaga ttcagtcaga aaacttattc aaagtaccta
69481 agtattataa aggagtcaaa aaggtacaaa gagaaaaggt caagacattt ttcaaatgag
69541 ggaaaactaa caggatttat cactagtaaa cctgctctaa aagaattcaa gggaagcttt
69601 ttaaaaagaa gggaagttat agcagaagga aacttagaat ggcaggaata aagaaggcat
69661 aatgtatagg gtaaatataa tagacttctc ttgaggtttt aaaaattaca tttgttattt 6g721 gaaagaaaaa aattaacgtt gttgtatgtg attctctgta gaggatatac agtttttttt
69781 tgttgttctt gtttctgttt ttttaaggtg aagtctctgt cacccaagct gaagtgcagt
6g841 tctgtgatca tggctcactg cagcttcacc ctgggttcag gtgatcctcc cacttcagcc
69901 tcttcagtaa ctgggactac aggcatgtac taccacgtcc agctaatttt ttttttcttt
69961 tttttttaga gatggggtct cactctgttg cccaggctaa tgccaaactg ctaacctcaa
70021 gatattaata ctatacagta gactataaga aattaagtat ttgtatcatc cctagagcga
70081 cacagatttt tccctaaaaa actacagatt attttcaaaa gcattaataa attaaggtgg
70141 aatactaaaa aagattcagg taacccagga acgagaaaca gaataaaaca atagtaaacc
70201 taaattttat tttatttcat taatacagca ataattaaat gtcaatgatc taagctgatt
70261 taaatctaaa aactggataa gaagctgtgg cttgtaatta aaaatagacc tttattcact
70321 agacctacag tttgcttttt tcatatgtta agaaaagttt aatatcctgc ttctctattt
70381 cagttctagg ggcaccacta tcagttaacc ctaaagattt ctgtgggtga aaccattttg
70441 attaccatct tgctctgctg ccagttatgg taaccaaact ctctttgttt ctggatgcta
70501 aatctgtcca cttgtgcctt aactacatcc taactcccgt catcttcatt gaatttaagg
70561 agccaatttc tttttttgag atggagtttc actcttgtcc aggctggagt gcaatggcac
70621 gatcttggct caccgcaacc tcagcttctc gggcttaagt gattctcctg cctcagcctc
70681 ccgaatagct gggattacag gcaggcacca ccatgcctgg ctaattttgt atttttagta
70741 gagacggggt ttctccatgt tggtcaggct ggtctcgaac tcccaacctt aggtgatcca
70801 cccgcctcag cctcccaaag tgctgggatt acaggcatga gccactgcac ccggccagga
70861 gccaatttca atgggagtat cctttactat cattcctgac ctgtgatatt ggccattaga
70921 gcctttcaag aatggtacct cctgccgatg atttttttta aagccttaat gaagagagtg
70 81 tcctctggat ccttccagag aagataggat gtgagtgagt aagttatgta taataatttc
71041 accccaaaat ttctatgtcc ttgataccat tccctgtata ccaaggaagg gtattctggc
71101 atttcacttt gatttaatat aagtaaaccc tgtgtctggg cattagttaa caaaccaagt
71161 gactacaagt gataagtaac ttttaccata gactgtcaat taccttggca atggaaacat
71221 tattgctttt taatccagtc agatcagaga acaaattcca gatttccatc cttaagattc
71281 tgtgtctctg ctaccacttc tggtagcaaa acatgtcagt gtgaggtaga gtcaatggaa
71341 tgtagccatg aaaaaaaaaa tgctactaca aacattacag gaataaggaa tttgatcgaa
71401 gaattagcat ttacacaaaa tatgggagga gttagggaag tgaaagaatg aaaggagaaa
71461 gaggataaag aaaacactaa ccacatcacc ctaaagccct tattgctaaa tgaggttatt
71521 gtagtgccag ttaagtccag gtcagccaag gcgtgcgtac cccttggccc cacttggaaa
71581 gctgtgtgga tatgactgtt ggattagggg gttctcaaag ccaaaatgga tttatcagca
71641 atgaccttac tgcctggtac ccagctttga gaggaccaaa aacgacggat gtgtcttgca
71701 ttccctggtc cctctttctt cttttaccca tatctaagtt gtttaaagga gaaaaatcct
71761 taggttgaag ccatattctc tctattcttg aaggaccaca gactctacgc ccctgttgaa
71821 attttctgga agcctatggg aaaggaggaa tgaaaagctt cgtgatgtct ttgaatacag
71881 gtgcctaagt tactatcgta actggtccag taaggagaag gggtatctga atttcaactt
71941 gggggctggg caaggtaacc agtgaggtgg ggagataaat agaacttggt agctaagacc
72001 cttcaggttg gcttgatgat gcattgtgat catggcttct acttcagatg tgttgctgga
72061 atagatatcc ttatacttgt aattccccta tacacaaatg ccagcaagaa tagtcccatt
72121 gaggacatgc taaatgtaga gaggtagtag tatgacatgg aaaacactcc ccaacttgtc
72181 tccctgtctc ctgcttatgt ggtacatggc cactgactac agtattaacc tttacttgag
72241 ccctgtgctt ctggaaaaca gtgacagtta agaaatccct ccttcttgtt acatttcagg
72301 aaatggctta ttgcaaagaa ccactagaac tgtgagtaac accttcattt acctatgata
72361 aagccagact cagaccctcc aaatcccatt ctttgcctca aaataattag ttgaactatt
72421 tgtacccata gactaatctg gacaaaatgc cctttaactt gacccaattt tatgcttctc
72481 ccttccccgt aagccactgg actttgatcc accttcagcc tgagccagca ctggactgtg
72541 gaatagtccc tccttttccc ctcctgaaaa ttgactagcc accaggaagg acattccctg
72601 ctSagctgtc ccattaacgt cacctgctcc tctcctccac gttagttttt ttctagcctg
72661 tttattcctc cctgtaagag aaaaagagaa aagcctattt ctatctgatc tttgagatgc
72721 ttgcagatct tacctttgaa gcattctcct tattgcaata gtctccctga ccctattgca
72781 atagttcctc tctccctgtt tgtattcacc cattcaggct gctatatata gcaaaatacc
72841 ataagctgat agcttataga caatataaat ttacttccca cagttctgaa gcccgggaag
72901 tcaaagatca aagtgctggc aggtctggtg tctggtgggg gcaccttctc actgtcctca
72961 catggtagaa gaagcaaggg aaactcttgg gcctctttag aggtactaat cccactcatg
73021 aggcctttac cttcttgacc tagtcatttt tcaaaggctc gacccatcat cattcgtatg
73081 ttaggatttc aacgtacaaa tttgtggggt tgggagggat acaagcattc agagcatagc
73141 actattttaa taatcatttc aaatagagtc attctatacc tagtctggat ttttgtttgt
73201 tttacttgac ctcattcact tgggtaggaa aaaaatctca tggactctca ttgatagccc
73261 caggggtaag gttggggcaa aaagagcaga ggcactcatt tactgtgagg taagaaatct
73321 gtttcagatc accttgtgtg caattcagga taaaattaat aaagatgaat agtaaaaatc
73381 caatactaag agataaaact caggagtcaa aagaagaaat cagaaagatt agagcataat
73441 tcagaatgta atgaaaacaa actatgcata gaaacttgtg gtattcggcc aagacagcat
73501 gtaggagaaa atgcaagtat tacctttctt gcttgtatta ggataaaaag ttgaaaatta
73561 acaagctaag tatctaactg aaagagaaag aaagaaataa taaaggtaac agcagaaatt 73621 aagaaaacaa ccatactgta gaaaaaacaa agcccaaagt tgagattcaa aaagagtatg
73681 gctgaaaaaa gagttttgac tattgattga atgtatttaa aatttaaatg gtcctttaaa
73741 tccttcaaac ttaatccttt aaacttcaaa aaaagtttaa atttggctaa cgcagtgact
73801 cacacctgta gtcccagcac tttgggaggc aaaggtggjgt ggatcacctg aggtcaggtg
73861 ttcaagacca gcctggccaa catggagaaa ccccgtctct actaaaaata caaaaaatta
73921 gccaggcRtg gtggtgggcg cctgtaatcc aatcccagct actcgggagg ctaaggcagg
73981 agaatcggta cagcctggga ggcggaggtt gcagtgagjcc gagatcacgc cattgcactc
74041 cagcctgggc aacaagggca aaactccgtc tcaaaaaaaa agtttaatac ataatttaat
74101 aaatttaaat agataaacaa ggtctcactc ttgtcttcca ggctgcagtg cagtgacaca
74161 atcacagttc attgcagtgt tgacctcctg ggctcaagct atcctcccac ctcagcctcc
74221 cgagtagctg ggatggcagg cttattccac cagctaattt ttgtattttt agtagagatg
74281 gggttttgca gtgttgccca ggcttatctc aaactcctgg gctcaaccga tctgcccatt
74341 tcgacctccc aaagtgctgg gattacatgc atgagccscc acacccgatt tgactcaata
74401 gtcaaaactc ttttttggaa acggagtttc gcgcttgtcg cccgggctgg agtgcggtgg
74461 cgtgatctcg gctcactgca acctccgtct cccgggtcca agtgcttctt atgcctcagc
74521 ctcctgagta gctgggatta caggcacctg tcaccacgcc tggctaattt ttgtattttt
74581 cgtagagaca gggttttacc atgtttacca ggctagtctt gaattcctga ccttaggtgc
74641 tccgcctgcc cctggcctcc ctaagtgctg ggattacεagg cgtgagcaac tgcgcccagc
74701 tgtcaaaact cttaattagc ccggtttggt agtgcatgcc tgaagttcca gctactcagt
74761 tgggaggatc gcttaagcct gggaggtaca ggctgcggtg agccatgatc atgacaccac
74821 acaccagcct ggtgacagac ttgttgacag accctgtctc aaacaaaata aaaacaacag
74881 gcagtaataa aaccttctag ccaccaagcc tagagagttt tattaatgag aatagtgagt
74941 tgtgagtttt gctaaatatg cggtttcttt gaattcc-agt tttatacaga aagtataaag
75001 ctcttgtcaa aattttacag taacagtacc aaaattaaaa ataactaaat ctcttttttt
75061 ttttttggat taaggtgatt tgttatttct ttttttttta attatacttt aagttttagg
75121 gtacatgtgc acaatgtgca ggttagttac atatgtatac atgtgccatg ctggtgtgct
75181 gcacccgtta actcgtcatt tagcattagg tatatctcjct aatgctatcc ctcccccctc
75241 cccccacccc acaacagtcc ccagagtgtg atgttcccct tcctgtgtcc atgtgttctc
75301 actgttgaat tcccatctat gagtgagaac atgcggtggtt tggttttttg tccttgccat
75361 agtttgctga gaatgatgat ttccaatttc atccatgtcc ctacaaagga catgaactca
75421 tcattgttta tggctgcata gtattccatg gtgtatatgt gccacatttt cttaatccag
75481 tctatcattg ttggacattt gggttagttc caagtctttg ctattgtgaa tagtgccgca
75541 atagacatac gtgtgcatgt gtctttatag cagcatgatt tatagtcctt tgggtgtata
75601 cccagtagtg ggatggctgg gtcaaatggt atttgtacgtt ctagatccct gaggaatcac
75661 cacactgact tccacaatgg ttaaactagt ttacagtccc accaatagtg taaaactatt
75721 cctatttctc aacatcctct ccagcacctg ttgtttcctg acttcttaat gattgccatt
75781 ctaactggtg tgagatgata tcccattgtg gttttgattt gcatttctct gatggccagt
75841 gatgatgagc attttttcag tgtcttttgg ctgcataeaat gtcttctttt gagaagtgtc
75gθl tgttcatatc ctttgcccac tttttgatgg ggttgtttgg ttttttcttg taaatttgtt
75g61 ggagttcact gtagattctg gatattagcc ctttgtcsga tgagtaggtt gcgaaaattt
76021 tctcccattc tgtaggttgc ctgttcaccc tgatggtagt ttcttttgct gtgcagaagc
76081 tctttagttt aattagatcc catttgtcaa ttttggcttt tattgccatt gcttttggtg
76141 tttcagacat gaagtccttg cccatgccta tgtcctgaat ggtaatgtct aggttttctt
76201 ctagggtttt tatggtttta ggtctaacgt ttaagtcttt aatccatctt gaattaattt
76261 ttgtataagc tgtaaagaag ggatccagtt tcagctttct acatatggct agccagtttt
76321 cccagcaccg tttattaaat agggaatcct ttccccattg cttgtttttc tcaggtttgt
76381 caaagatcag atagttgtag atatgtggcg ttatttctga ggcctctgtt ctgttccatt
76441 gatttatatc tctgttttgg taccagtacc atgctgtttt ggttactgta gccttgtagt
76501 atagtttgaa gtcaggtagt gtgatgcctc cagctttgtt cttttggctt aggattgact
76561 tggagatgtg ggttcctttt tggttccata tgaactttaa agtagttttt ttccaattct
76621 gtgaagaaag gcattggtag cttgatgggg atggcattga atctataaat taccttgggc
76681 agtatggcca ttttcacaat attgattctt cctaccgatg agcatggaat gttcttccat
76741 ttgtttgtat cctcttttat ttccttgagc agtggttfcgt agttcttctt gaagaggtcc
76801 ttcacgtccc ttgtaagttg gattcctaag tattttattc tctttgaagc aattgtgaat
76861 gggagttcac tcatgatttg gctctctgtt tgtctgttat cggtgtataa gaatgcttgt
76921 gatttttgta cattgatttt gtatcctgag actttgctga agttgcttat cagcttaagg
76981 agattttggg ctgagacaat ggggttttct atacatacag tcatgtcgtc tgcaaacagg
77041 gacaatttga cttcctcttt tcctaattga atacccttta tttccttatc ctgcctaatt
77101 gccctggcca gaacttccaa cactatgttg aataggagtg gtgagagagg gcatccctgt
77161 cttgtgccag ttttcaaagg gaatgcttcc agtttttgcc cattcagtaa acatggaaaa
77221 atagcaaatt agagacagtg ggtattaaca attgcatata tcacaataaa tgtatgttta
77281 atctcaggaa tgcatggcag ttctgtcttt agaaaatgta ttttttgtat ttttatcaat
77341 ttagagatgc ccttttaaaa aaacatatta caaattggaa tattcaaagg gcagctgttt
77401 tattttcttc cttgctgaaa cataaaataa tgacgtgttt taaaatttat agaatctttg
77461 atttgatcaa atatggtaat gtaatttgcc attctaacag atcaaaatca gaatcagtat 77521 gatcatctat cttgatttgc gagaagcatt tgataatatt caaaatccat ttatgaaaaa
77581 actcttggca gaggagaaac agcaaagaat ttttaaaata taaagggtat gtacaaaact
77641 gtagtaacca tcttactgaa agatcaaact tgttcccttt cagcttggga ataagacaga
77701 gcttcctatt aagaccacca catctactca tctttaagct ggtgattctc accaacacat
77761 ctaagcatga aagaaataaa aattataaga taaaaaggaa agaaaactct cagtacttaa
77821 agatgatata attacataga aaatcaagaa gattccatgg ataggcttcc caaaaaacaa
77881 tatgtaacat accagcaaca aatggtaaga aaaacacgtt gttttttttt taaagtacat
77941 tttcagtgac attaaataat aaggattcag gaatacaacg aatataacaa aaatgtaaga
78001 tatctaggga tgcgtataac aaaaaaatta taaagcttca tttaaaacat ttttaaacaa
78061 aataagtaga aagtaatacc atctttatgg aacagagtca gtattataaa tgtgtcagtt
78121 ttcttcaact ggtccataga caacacaatt ttaactaaga ttccaattgg gatttctgtg
78181 gaacttgatg agttagggcc aaaagtaatc aagatattca tgaggaagga taacagaatg
78241 gcaaaacttg ctttaataat ttgtgcaggg atagacaaat actgtacacc agtctctcaa
78301 tagggagatc aaaaccaaat tcacacagac atgaaaagtt gatttatgac agatgatgtt
78361 gcagtccctg gggaaagaat ggaaatggtg ctagaataat tggtttctat atgtatttct
78421 atatatttat atgccattac attaaagtca atgcctatgg agtttgggag gagtgatcaa
78481 aatgttctgg aattagatgt gatgtttgca caactctgtg aatgtactaa gaaccactga
78541 attgtatatt tttaaagcat ggtatgtgaa taatacctca ataaagctgt tataaaaaat
78601 attttaaaaa tcccagcact ttgggaggct gaggcgggcg gatcatgagg tcaggagttc
78661 aagaccagcc tgaccaacat gttgaaaccc catctctatt aaaagtacaa aaattagcca
78721 gacgtggtgg cacgtgcctg taatctaagc tactcaggtg gctgaggcag gaaaatcgct
78781 tgatccctgg aggcggaggc tgccgtgagc cgagatgatg cgcctggcac tccatccagc
78841 ctgggcaaca gagcgagatt ccatctcaaa aaaaaaaaaa aagtaaaaaa tcaatgacgg
78901 ccaggcgcag tggctcacac ctgtaatccc agcactttgg gaagccgagg tggcagatca
78961 cctgaggtca ggagttcgag accagcctga ccaacatgga gaaaccccgt ctctactaaa
79021 agtacaaaat tagccgggtg tggtggtgca tgcctgtaat cccagctact ggcgaggctg
79081 aagcaggata atcacttgaa cccgggaggc ggcggttgtg gtgagccaag aacgcgccat
79141 tgccctccag cctgggcaac aagagcgaaa ttccatctca aaaaaaaaaa aaaaaaaatc
79201 aatgccagac agactgaaaa cttaacatgc aaagggcaag tattgaagac caaacagata
79261 gcaatatttc accacaagag ggcagtttga ccctgaactt tggtgtgtgt ttgttttgag
79321 atggagtctt gctctgttgc ccaggctgga gtgcagtggc gtgatcttgg ctcactgcaa
79381 ccctccacct cccggattca agtgattacc ctgcctcagc ctcccgagta gctgggacta
79441 caggcacgtg ccaccatgaa cgactaattt tttgtgtttt tagtagagac ggggtttcac
79501 cgtgttagcc aggatggcct tgatctcctg accttgtgat ctgcccacct cagcttccca
79561 aagtgctggg attacaggcg tgaactttga ttttatacag gaagtggttg gaggaaatgg
79621 ttggaaagga tgtttcgtga ctcaaaagac tactggggat taactagctt gatagcagtg
79681 gccacaagtt aagattaccc tggaatccag tcaaagctgg tgttatgatt ctagtttgag
79741 ctagtatctt cctggagcca gtaacatgaa tatgatgacc aaatgtttat ttcgtctgaa
79801 aacaaaagat tatggacaca acttcgtggt atgtgtccat ttaggcccac cgtaaagaag
79861 tgaagcactg gcatcaacca caaagaaagt tatgtgagca ctttctctgg atgataaatt
79g21 atcttctatg tgcatgtgca tgtgttgtgt atgttgacag gtcacacatc agaaactgcc
79981 acttcatagc cgaaggatag tcctatatgg aaacgcaata tgaaagtgtg attaataata
80041 taggcttttg tgcctcctgg ccccggcatt gccactgaat tgtgtgactt tgggcaagtt
80101 acctatgttt cagtgcaact gtaaaatgag gataatat ta gtaattacct catggtattt
80161 tttttcttct tttttttaat tatactttaa gttctagggt acatgtgcac aacgtgcagg
80221 tttgttacat atgtatacat atgccatgtt ggtgttctgc acccattaac tcgtcattta
80281 cattaggtat atctcttaat gctatccctc ccccatcccc ccaccccacg acaggcccca
80341 gtgtgtgatg tttcccttcc tgtgtccaag tgttctcctt gttcaattcc cacctatgag
80401 tgagaacatg cagtgtttgg ttttctgtcc ttgcgataat ttgctcagaa tgttggtttc
80461 cagcttcatc catgtcccta caaaggacat gaactcat cc ttttttatgg ctgcatagta
80521 ttccatggtg tatatgtgcc acattttctt aatccagt ct atcactgatg gacatttggg
80581 ttggttccaa gtctttgcta ttgtgaatag tgccgcaata aacatacgtg tgcatgtgtc
80641 tttatagcag catgatttat aatcctttgg gtatataccc agtaatggaa tggctgggtc
80701 aaatggtatt tctagttcta gatccctgag gaatcaccac actgtcttcc acaatggttg
80761 aactagttta cagtcccacc aacagtgtaa aagtattcct gtttctccac ttcctctcca
80821 gcacctgttg tttcctgact ttttaatgat tgccattcta acgggtgtga gataaacttc
80881 tccgagctaa aagaggaagt tcgaacccat cagaaagaag ctaaaaacct tgaaaaaaga
80941 ttagatgaat ggctaactgg aataaccagt gtagagaagt ccttaaatga tctgatggag
81001 ctgaaaatga tggcacgaga actacgtgac aaatgcacaa gcttcagtag ccgatttgat
81061 caactggaag aaagggtatc agtgattgaa gatcaaacga atgaaatgaa gtgagaagag
81121 aagtttagag aaaaaagagt aaaaagaaat gaataaagcc tccaagaaat atgggagtat
81181 gtgaaaagac caaatctatg tctgattagt gtacctgaaa gtgatgggag gaatggaacc
81241 aagttggaaa acactctgca ggatattatc caagagaatt tccccaacct agcaaggcag
81301 gccaacattc aaattcagga aatacagaga acaccacaaa aatactcctc aagaagagca
81361 actccaagac acataattgt gagattcacc aaagttgaaa tgaaggaaaa aatgttaagg 81421 gcagccagag agaaaggtcg ggttacccac aaagggaagc ccgtcaaact aacagcagat
81481 ctctcggcag aaactctaca agccagaaga gagtgggggc caatattcaa cattcttaaa
81541 caaaagaatt ttcaacccag aattttacat ccagccaaac taagcttcat aagtgaagga
81601 aaaataaaat cctttactga caagcaaatc tgagagactt tgtcaccacc aggcctgccc
81661 tacaagagct cctgaaggaa gcactaaaca tagaaaggaa caaccagtac cagccactgc
81721 aaaaacatgc caaaatgtaa agaccatcaa tgctagaaag aaactgcatt aactaacgag
81781 caaagtaacc agctaacatc ataatgacag cgatcaaattc ccacataaca gtattaacct
81841 taaatgtaaa tgggctaaat gctccaatta aaagacacag actggcaaat tggataaaga
81901 gtcaagaccc atcagtgtgc tgtattcagg agacccatct catgtgcaga ggcacacata
81961 ggctcaaaat aaagggaggg aggaagatct accaagcaaa tggaaaacaa aaaaaggtag
82021 gggttgcaat cctatctctg ataaaacaga stataaacca acaaagatga aaagagacaa
82081 ggccattata taatggtaaa tggatcaatt caacaagaag agctaactat cctaaatata
82141 tatgcaccca atacaggagc acccagattc ataaagcaag tccttggaga cttacaaaga
82201 gacttagact cccacacaat aataatggga gactttaaca ccccactgtc aacattagac
82261 agatcaagga gacagaaggt taacaaggat atccaggact tcacctctgc accaagggga
82321 cctaatagac atctacagaa ctctccacca caaatcaaca gaatatacat tcttctcagc
82381 accacattgc acttattcca aaattgagca catagttgga agtaaagcac tcctcagcaa
82441 atgcagaaga acagaaataa caaactgtct ctcagaccac agtgcaatca aattagaact
82501 caggattaag aaactcactc aaaaccactc aactacatgg aaactgaaca acctgctcct
82561 gaatgactac tgggtacata acgaaatgaa ggcagaaata aaggtgtttt ttgaaaccaa
82621 tgagaacaaa gacacaacgt accagaatct ctgggacaca tttcaagcag tgtgtagagg
82681 gaaatttata gcactaaatg cccacaagag aaagcaggaa agatctaaaa ttgacaccct
82741 aacatcacaa ttaaaagaac tagagaagca agagcaaaca cattcaaaag ctagcagaag
82801 gcaagaaata actaagatca gagcagaact gaaggaaata gaaacacaaa aaacccttca
82861 aaaaatcaat gaatccagga gctggttttt tgaaaagatc aacaaaattg atagaccact
82921 agcaagtcta ataaagaaga aaagagagaa gaatcaaaca gatgcaataa aaaatgataa
82981 aggggatatc accaccgatc ccacagaaat acaaactacc atcagagaat actgtaaata
83041 cctctgtgca aataaactag aaaatctaga agaaatggat aaattcctgc acacatacac
83101 cctcccaaga ctaaatcagg aagaagttga atccctgaat agaccaataa caggctctga
83161 aattgaggca ataattaata gcctaccaat caaaaaaaga cctcatggta tttttatgga
83221 atgtaaatca gtttatagat gagcaggagt ctagtatcat cctttaagac atatctggtt
83281 tttatagggt cagaccggtg aattaagtag gcacttgatg gggatcacag tgcctgcaac
83341 ttttgggtct ttaaggatga ctttaacgtc taccatagtc ccaggcaata ttgtttttaa
83401 tttacaatat aattttttta catttttaca attatttata atatttgtct tttatgtaca
83461 atattgtcaa tgccgtattc ttttaaaatt tactatattg gctgagacag gatgagaggg
83521 acagtttcag agtctccact tggctttccc cacttccgta gctcttacac cattggttaa
83581 gaaaccagtg tgggggttgt gctaactaca aagtcagtga ccagggaaat aatcactgat
83641 gggtcatgaa accagtgaac ctactgtgag tgggatcttt gcaaggaccc catgtatcat
83701 ctggcaacca taaccctttt ccccaacaag gtggccatga taatgcccct ttgaattaat
83761 tctgcattaa ttcttaggta ttaatgtcaa aacagactct gccaccaaca aactcctcaa
83821 aatgccttgg cttgtctctt tcccttgtat acagtaacct gagtaaatgg ccacaggtct
83881 ctttgggata ggtatgagag aatcattgta aacacttgca ttatagggtt tttctcacgc
83941 aagatcctca ttgttgttca gtcattgggt tctgaatctg aaaaaggtct caagttctga
84001 aacagggaag acatcatgac tttttgttgg gaagtgctct caggatttta gtcatctatc
84061 tttgttgtgt atcatatggc atgtactctt tgtgtctggc ttctttcatt aagtacaatg
84121 attttgagat ttacacagat tgttagtgca tcgatctttt tatttttgaa tagcatccca
84181 tttaattgat tccattgatt gcaatgctgc Gtgtctctct tgcccttagg gactcatgtt
84241 ctcttaatct tcatagctct ccgagggtcg gaaactccat tacttgctac tcagactttg
84301 ctgttattac agtaattaag cctattttgg ttctgatggt ttagatttgc caccaggcac
84361 cttttgtttg gggatcctgt tattcccatt gccatcatgt agcgtagttt ggtaccaaca
84421 tcaaccatca gacttagcca ctggtgtcta gaaccagctc tcacaagatg gatttattct
84481 catcaactct cacaagattg ttacattttt tgaagtttta tgaaccagtt gttacccaag
84541 atgttgaatg taatatgaca ggagaatgat ccatccttat gtcgatatac tctcccttat
84601 ccaacattat tctccttgac tgcattttca tgttccagtc tcatgtgtat tttctcagct
84661 cttgccagta catcttaact aggacctgca gcgccttttc ctccataaca gacccagcac
84721 ccccaagctg tgttatatca tgattgatcc taatttttta ttgggtagcc agaatgtgag
84781 gtgggggttg cattactctg ttctcacatt gctataaaga aatacctgcg attaggtaat
84841 tgataaaaga ggtttaattg gctcacgttt ctgcaggctg tacaggaagc acagtgctaa
84901 caagtgcttg gcttctgggg aggcctcagg aaacttacaa ccatggcaga aggtgaaggg
84961 ggagcaggca tatcacatgg ccagagcagg agcaagaaaa tgagggggag atgcttttaa
85021 atgaccagat cttacaagag ctcactcact gttgtgatga cagtaccaag acgatggtgc
85081 taagccattc atgagaaatc tgccaccatg atccaatcac ctctgaccat ggcctacctc
85141 caacattggg gattttttat atgagatttg ggtggggaca cacatccaaa gtatatcagg
85201 tgtgtatcct gggcagaggt gggtgggtgg ggggtggcat ttatcttgca aagtagagga
85261 cttggcatca tcttccagga aatgggtaga gctaaccttt aagagaggga gaggagaagg 85321 ctgcttgtgc cagcccggag gaatcagggg aagtgcgatt caagattttc agcatattaa 85381 ccaagaggac ccattccaag tcttaagatc acagtccttc ccatcaatac cctccctgac 85441 cttgatgaag ccaacttgcc tgagttgaga atcatatatt tctagagctt gttcactact 85501 cttggaatta aaggctgaat ctgatcctca gttttttctg cctccagact acaagagatg 85561 agcatctgct gccaaagagg ccttctagct ttcacacttt gccttcagtc gatgattaat 85621 acccttagcc tttcatttcc cccccaaagt attcattgat agcatttagc aatgatcata 85681 ttccactttt tttgtttaca gatttattga agtttaattg atgacaataa actacatatg 85741 tgtttgtatg tatgtgtgtg cagtgcacaa tttgctaagt ttttgtttgt ttttgttttt 85801 gagacagggt ctcgctttgc cacacaggct ggagtgcaat ggcacagtca tagctcactg 85861 caacctcagc cttccacatt tggtaagttt tgacatRtat ctatgaaacc attatcaaaa 85921 tcaagacaac aaacatttca tcaaccccaa aagtttcctc ctgctccttt tagttttatc 85981 cttccttcta tccccaggta actcctgatt tgctttctga taggttagtt tgcattttct 86041 agaattttat ataaatggaa taatacagca tgtattcttt tttttttttg gtctggctac 86101 tttcattaag tataatgatt ttgagattta tgtatctcgt tggtgtatca atctttttat 86161 tgttgaatag tgtatcccat ttaatagatc tatcaaatgt gtttatccat tgatctgttg 86221 atggacattt gggctatttc caggtttggg ctattatgaa taaagctgct atgaatattc 86281 atatacaagt ctttgtgtgg acatgttccc atatttcttg aataaatatg tagaagtgga 86341 atggctggga tatttggcaa aagtgtttta agttttcaag aaagtgccca tctattttcc 86401 agtcattgta ctcttttgca ttctcatcag cagtgtagga gagttccagc tgccccacac 86461 cttcaccagc agtgggcaaa gtcttttaac tttagccatt ctagtgggtg tataatggta 86521 actcattgta gttttttcat ttcattttta aattgaggta caattgacat gcaatgaact 86581 gcacctattt aaactgtaca atttgatgag tttgacatat gtatatacca atgaaaccaa 86641 cacaatcaag atgataaata tattcatcac cctcaaaagt tttctcatac ccctatgaaa 86701 ttctatcttc tctcccctcc ttgctcctga ttccctaccc cagataacca ctaatcttcc 86761 ttctgtcatt agtttgcatt ttctagagtt ttatacaagt ggaatctaca gtatgtactt 86821 tatatgtatc aataggtcat acctttttgt tacttacatc tttgttactg tgacatattt 86881 cactgtatgg ctaaaccatt attagtttac ctgttgacag acatttgggt tgtttctaat 86941 ttttgccaaa cacaaataaa gtggctatga acatttacat acaagtattt gtatggactt 87001 aagctttaat ttctcttagg taaataccta aggagtagaa tggctggatc atataatagg 87061 tgtatatagt atttaacttt tttttataac actgtaaaac tgtttcatag tggttgtatg 87121 gaaataaaaa tgagaaacaa aataaaacaa atgtatacca aaacatgttt aatgtttcac 87181 cttcaagaaa agggagcact ttacaatgag tgagaaaata tatatccaca ttttgaaaaa 87241 aactccaaga taaaaggcat tttgacaaca gatatttgga aatatttcca tcgttacaag 87301 agtttattgt caaaaatgat gtatgtccat ctataaaact ctcctatctg ttgctaaaac 87361 aaatttatct gctctatttt taaatatttt caaaaagtta gttttaaacc tatttgttta 87421 aaatatgaaa atgcaaaacc ttttattgct tccaagagta atttattgac atcgaagaaa 87481 atataaattt attacttaaa caaaaatctt cctttttagc tcctcttttt tgttttgttt 87541 ttataactgg acagataata attgtacata ttcatggggt acatagcgat gtttcaatac 87601 atatactgta gtgattagat cagggtaatt aacatatctt tttaattggt gaatggagtg 87661 aaaaattaat actctgattt agtaagtgaa gctaactctt ccatttgaat ccatacttct 87721 ctgcaggatc ttttttagct ttgagagcca ttaacaccaa atattgaagt aaactaaact 87781 tataaccaga ccatcatatc attttatctc ataaaatgaa gcaagtattc ctgtcacttc 87841 tgggaacaca actgaacagt attgtttact agtgaaaaaa aattgagttt tcaagtgaaa 87901 attggaattt tggaaaactt gtatcctccc tatgagcttg acagcttccc aatatttaga 87961 gacttttatg atatatttat ggtgagacca gtgataatat taacaattgt tatttttgaa 88021 atattgctta atgaaaccca tcaataccaa cccaaatttt ataaaaacaa agcatattta 88081 aaaacatttc ttgggagggc atggtggctc atgcctataa tcccagcact ttgggaggcc 88141 gaggcaggca gattacttga ggccagaagt tcaagaccac cctggccaac atggtgaaac 88201 ctccatctct acttaaacaa aaaaacagaa ttcttgcaat ataggtgacc ctcataaatc 88261 acataactct tctgagagta aaagaggtgc attttttgtt agagttatcc agacttttta 88321 cattaattat atttatattt ttcagatccc aaattggcaa aagttggaga atttttctta 88381 aattacaatt ttcttctgcc agagccaaaa atgtaagaaa actcctagat accatggtta 88441 tatccataat cttaaaatta ttgt ctcag cacaatgaag aaattattga gaacaagtcc 88501 cttccaaaga aaaaaaaatc caataagaga ttaaatatgt attgtaattt tagaagacag 88561 ttaagttgca tcctcacata gaatgctctc tcagacactg gcttattcta aatgcgtcag 88621 caagtaatca aagagtacag taaatgccta ttcttcctta gaacactgct ggaacagatt 88681 tccccctaac cctggctaag gctctcttta tttattagat ggattaaact taattccctt 88741 gatttgtact tattctaata acagt tgatc cataggaatt cagaaaggct ttttcagact 88801 tgagatttaa gtgcaatgtc agctt tttt gttttttttt cttttttcag tttggctaaa 88861 gcaaagcaag ggaattgttg ccaagtagag cacactatgc agaacctggg acatatagga 88921 tgactcagca ttgcatttta gtctcatgac tttgctggga atcagatgca gctatcgaga 88981 ataccagtag cattggcttt aggtt tagta gccatgagtt gagtttagga aaggcagaat 89041 cttactaagc aaactcctga ttattgctgc aagaacttct tggtcaaagc attcttgaca 89101 aatcatcctt gaaaaactct ttactatatg gaaaacgtaa agaacaatgg gtgagagcac 89161 aggctctggg tttgaacctt ggctatacca ccacttacac atcatgtgac cgtggttaag 89221 tcccatcatc actctgtgtc tcagttacca tatatacaaa ataacaataa catactgcta
89281 aatacttact aaatccttta catttattat gaatataaac cacatgatcc tatgtggctt
89341 atattaataa taaatataaa ggatttagtc tggtactaaa tgaccagtaa atgttattta
8 401 taattggttt attttattat ttatttattt agacagagtt tcactcccat tgcctaggct
89461 ggagtgcagt ggcactcagg tgattctcct gcctcagcct cccaagtagc agggaccaca
89521 ggtacaccac catgcccagc taattttttt tttttttttt tgagatggag tctcactctg
89581 tcaccaggct ggagtgcagt ggcatgatct cggctcactg caacctccac ctcctgggtt
89641 caagcaattc tcctgcctca gcctcccaag tagctgggac tacaggcgtg cgccaccatg
89701 ttcagctaat ttttgtattt ttagtagaga cggggtttca ccatattgtc caggatggtc
89761 tcaatctctt gatcttgtga tctgcccacc ttggcctccc aaagtgctgg gataataggc
89821 gtgagccacc acacctggcc tgctaatttt taatattttt tgtagacaca cggtttcacc
89881 atgttgccca ggctgctctt gaactcctga gctcaagtga tctgcctgcc ttggcctccc
89941 aaagtgcgga gattacaggt gtgagtcacc atgccagacc agtttgcttt atttcttaag
90001 cctcacaaca tccctgtagt tattgtgggg taggtatctg ctatggtttg aatgtccact
90061 ccaaaagtca tgttgaaatt taattgccat tgtaacagta ctaagaggtg gaacctttaa
90121 gaggtgatta ggccatgaga gctctcataa atgtattaac gacattattg tgggagtggg
90181 ttcattattg caggacaggg ttcctcataa aaggacgagt ttggcacccc atttgtttct
90241 ctctgactct caaggtctct tgcttttcca ccttctgcta tgggatgtca taacaagaag
90301 accttcatca gatgctggta ccttgatctt gaactttccc acctgcagaa gtatgaggac
90361 ataaatttct attcccttaa aattacccag tctgtagtat tctgttatag cagcacaaat
90421 cagactaaga cagtatccct aagggtaaat tgagtttatt tctgagagta aactgaggct
90481 cagaagttaa ttgtccattg acccagagcc tgtgtgtggc agttcctgtg attccaaaca
90541 aggcacttcc caatatgtca ttctaaatct acaaatttca tttatgtctt gtaagtgtag
90601 aaatcagaaa catcatacaa gctcagtctc ttacgtggtc ttagacttcg ccaaattaag
90661 aagatttata gaattaataa ataagtgtat gaggctgggc gcaatggctc atgcctgtaa
90721 tcccagcact ttgggaggcc gaggtgggtg gatcacctga ggtcaggagt ttgagaccag
90781 cctggccaac atggcaaaac cctgtctcca ctaaaaatac aaaaattagc cagtagtggt
90841 ggtgcatgcc tgtagtccca gctactcagg aggctgaggc aggagaattg cttgaacccg
90901 ggaagcggag gttgcagtga gccaagatcc caccactgca ctccagtctg ggcaacagaa
90g61 cgagactctg tctcaaaaaa aaaaaataaa ttaattaaaa agtgtgtgat attgaacttt
91021 gactcttctt gaacaaagcc tgcattattt aattgttgag tttatttaat tttctgttga
91081 ctatattttg ttttgttgcc ttaatatgat aataggacag agacagtatt gtagagagtt
91141 cagcacagtg gcctgaaaaa ttgaggatac tagaaaagtt cttttatata ttaatctatc
91201 cagcagatat ttattgcagc ccctattgta tgcaggcact gctgtgatac agcaatggat
91261 acatcagaca aggttcttgc tcttatagaa atgacattat agagagagga gaagaacatt
91321 tattccatca ataaatacat aaaaaagaca atttcagata gtgtaagtaa cagctaagaa
91381 aacaataaaa caggatgatt ggatacagga gatgggaaga gatggtgaga agtggggaag
91441 gcttagatat agttaaatgg aaaggcttgt ctttggaggt ggcatatgag ctcagtactt
91501 cttttttttg agtcagagtc tccctctgtt gcccaggctg gagtgcagtg gcaYgatctt
91561 ggctctctgc aacctctgcc tcctgggttc aagcgattct catgcctcag ctgggattac
91621 aggcgtgtgc caccatgccc aggtaat tt tgtatttttt tgtagagaca gggtttcgcc
91681 gtgttgacca gcctggtctc gaactcc ga ccgcaaatga tcagcccacc tcagcctccc
91741 aaagtgctgg gattacaggc atgagcc ct gcacctggcc ctcaatactt tgatcattag
PELI2 genomic sequence (SEQ ID NO: 9)
>14:PE I2
TACAACCAGGCTGCTCTTCACCGTGTTTGGGCTGCTGΪTGGCTCTACTGGT[C/T]GATAAAATATTGAAACACTTTCTTATCAGTT GATGAATAATACAACAGTA
LOXLl genomic sequence (SEQ ID NO: 10)
>15: 71935151-72007300
1 gagtagctcc cgggtgctgc tggccggcgc gccccaggcc cagcagcggc gcagccacgg
61 gagcccccgg cgtcggcagg cgccgtccct gcccctgccg gggcgcgtgg gctcggacac
121 cgtgcgcggc caggcgcggc acccatt egg ctttggccag gtgcccgaca actggcgcga
181 ggtggccgtc ggggacagca cgggcatggc ccKggcccgc acctccgtct cccagcaacg
241 gcacggggRc tccgcctcct cggtctcggc ttcggccttc gccagcacct accgccagca
301 gccctcctac ccgcagcagt tcccctaccc gcaggcgccc ttcgtcagcc agtacgagaa 361 ctacgacccc gcgtcgcgga cctacgacca gggtttcgtg tactaccggc ccgcgggcgg
421 cggcgtgggc gcgggggcgg cggccgtggc ctcggcgggg gtcatctacc cctaccagcc
481 ccgggcgcgc tacgaggagt acggcggcgg cgaagagctg cccgagtacc cgcctcaggg
541 cttctacccg gcccccgaga ggccctacgt gccgccgccg ccgccgcccc ccgacggcct
601 ggaccgccgc tactcgcaca gtctgtacag cgagggcacc cccggcttcg agcaggccta
661 ccctgacccc ggtcccgagg cggcgcaggc ccatggcgga gacccacgcc tgggctggta
721 cccgccctac gccaacccgc cgcccgaggc gtacgggccg ccgcgcgcgc tggagccgcc
781 ctacctgccg gtgcgcagct ccgacacgcc cccgccgggt ggggagcgga acggcgcgca
841 gcagggccgc ctcagcgtgg gcagcgtgta ccggcccaac cagaacggcc gcggtgagta
901 cggccccggc gcccctccgg ccgcgcgtac ccctggccac tggaaactgc tccgggcccc
961 ccgggcccct ccttagaact tcctggaggc ctccccggag ctgctaagca cggagcagcg
1021 ccccctcccg acttcccccg acccagccaa cagcaccccc ctggcatctc acctcccagc
1081 ttaacccgca cccaggcatc atcagtgcca ggggttggcc aggcaggtgt gggctctgat
1141 cctggctttg gtggagggac tagccgagct ttgggaggag gctcgccttc tgcacttggc
1201 ttgggtcatc tgaggacaaa aggaaggagc ccctcatcca ccttctccct catttcaatg
1261 agggcatctc cttcccccct tagagatgtt ctatgccagc tcacagggtg aggcaaggag
1321 catcagaaac ctgagtcttc agggccagaa aggccttaag ggatgcccct ggaggtgtgg
1381 caggctgccc attactgggc atgtgtgagg ttggcttgag tgcgcaggag gttagagggg
1441 agcgtgtgct ccaggcagga gtccggactt cctcagggga gtctgcaagg ctggggcaag
1501 agagaccagt caggcactgg cctgggtgca gaatttcagg ggctaccaaa aaacacagta
1561 gttgagatga gtaatattga gatgtatttt tttaagtcaa aattaatgca aaaaaaaaaa
1621 aaaaaaaaaa aaacctgtga taaaggaaat atccagattt taaatagagt cagtaatagt
1681 ggtatgccga gccatattgg agcctgaggc taactgaaaa atcagcaaca cggatcctgt
1741 ctttatttga tatttggata ttttgttcat tacagatagt tttgcattaa tttttatttt
1801 aaaaactatt gtgttaaata ttaYttatct ccgttactga gtttttttgg caccccctaa
1861 aattttgcac cccgaggaaa aaaaaaaaaa aacacctcac tggcctcatt cccctcaccc
1921 tagtcctggc cctggcggag agccccagct gtggacagga ctccctctgg cttttcaggg
1981 ggtgaacata cgtcctcctc ttgggaaggc ccaagccctc tgcacatgag gacacagtgg
2041 aaaggcagct tccacaYatg ctgttagcag acagggctac tgtgacaagg gctgactggt
2101 gggtgtggcc agtgctggac ggccatcagc cattctctgc tgtcctagaa tccccctccc
2161 tgctaccctc tccatacagg cagcttttgg gccaaggttt tctactcagt ccccaatact
2221 tatgcagtcc aactctgcct tgcctctttc aagctgtcgt cagtttcctc tacccataat
2281 tctctgctcc ccattgaggt tgctgWgcct ggcccaccaa gtaagggctg actgagccct
2341 ccagtgcctc agagtatagg tgctagtgcc ccagcctcct cctcagcctc tgtcagcaga
2401 gggatgatgc tttgtctcca gccaagctga cctcagtgag gggctgctgc tcatggggtg
2461 cctgtctccc tgggtactgc tggaggccaa gactagggga gaggagcgtc tccactggga
2521 acactcactc tatcacatcc aaggtgtcgc ttttgagttg tgtgctgaat cccactttaa
2581 gaacctgcag gagctcagga aaaatcagat ggcaggtcct tctgtggtgt gatgaaggat
2641 gcatccacct gctctggtcc ttaccaggta cttgcagcat ccctgcagaa gggcgcatta
2701 tagccatgca tcagctgctc tagggcccct tggagaatag gatgttttac ctagagggtg
2761 ctaaactttt gcagtggctt ttcttagaat gcaagacctc agcatgaggc tcagcctgat
2821 gggccccacc tctgggcaga gaaaactgag ctctcaaatg ccacaataYt ggcagaggca
2881 tgcctgggac ttggcatctg ggcaccaagt cagtgggtct tctagggcct gtctttgggc
2941 tgttagttct taaggaagcc agttgattga gaggggaatg ggacagggca aggccatgtc
3001 tgaagtgggg gtgcttggtg cttagcagac ctctggccac taccctgagc cccacagttc
3061 attttgggtc aaaaacattt ctcccctgaa ggtagcatcc taggtgccaa gctgagtgta
3121 ctcacatgca tcaagtccag gcccttccct ggggcagtct accaggaggg gcatctcagt
3181 gctgtgatta ggcaagcatt ggtggggcca ggggctttgt gagcccagag gagggccctc
3241 cctgtcaggg gctagggctc agggagactt ccacaggaag caatgtctaa gcattgctgc
3301 aagggatggt catcagcacc atccaggtgc cccttcccct aatcattgag ggtgtggggt
3361 gggagtgtgt tttttgctgg ggaggggatt gcaggctagt ttagggctca caaagaggcc
3421 agagagggag cagtagtctc tcccatcatt ggttcctccc tccccaccct gctaggccag
3481 accgtggaaa atcccagccc agggaaggcc aagccttgtg cttgagatca gacccccagg
3541 cctggtgtgg gagcccaagg cggattctcc gagactgact tcattcctcc tggccacaca
3601 cccaggggtc tgaggctggg cgctggcagc ctgtgagtgt gtgtgggcgt ggacgtgtcc
3661 tcacaacacc aagcacatgt gagcaccacc cacctccctc catgggtggg tggtttccaa
3721 gcgcctgtcc tgagcccagt ttcttcctcg ggtacctgtg ccctcttcct tcctaccctg
3781 ggcactgaga ctgcccaagg cttcctgcag taccattctc tccaactctg aaacatgaaa
3841 ctgaaaagaa actagaggaa acagaggccc agagagggtc acatactttg cctggctctc
3901 atagcaaatc cttgaagaga ggcctggagg gtggccagcc acttcccagg cccagctggg
3961 tctcctgcac tgtgtMggct ccctcgatgt gaccactcct gctattacca accaggccct
4021 cctctcctgg gatcctcgcc tcagctcctg cctccctgga gtttcagctt gtctgagctg
4081 ggggtcttag tgccacctaa gaagccccac agccccagaa gaccaaagct cccctcccaa
4141 ggccttaccc tcgcaccccc cgcctgactc accggctctg gcaatcctgt gaaaggaaca
4201 tggaacaggc agccctgggc atcctcccag ggcatcttgg atggctgtgc tagccttgcc 4261 tgacgtgtgt cctctatccc tgacttcNcM tggccaatca gaggccagga gagaaccgca
4321 gctgcctcct ccctggtccc ttgctcccag tctctccctc ttcagtctgt cctgcatgtg
4381 gggcagataa acccctgcag tctgaccagg ttactcctct gctcaagaag attStgtagc
4441 tcctcagggc ctttaggaca aaatctagtg tctcagccca gcactccaga gttagaggca
4501 cctccttcct gtcctttctt cctccttttc tcaagcctcc acagccccca tgggaccatg
4561 ctgctcgtgg gcctagatgt tacacctccc tagacacatg caagggtgtt tctagggtac
4621 ctccttctct gtccagcctc ctgcacccaa gaggccagac ctgtctggac cctcagtccc
4681 tgagagcagc cctggctgcc tgctaccacc tctcctgcct gagcccctag ctcacctggg
4741 cctgctccac cccacctcca caggctgcct gcccacctct gccctccagg tcactcgcct
4801 tcccctgcag agtttggagt agatgcaggg aaggaccaaa gcaggcttca cccaacaagc
4861 ttccagagtt agagcccaga ggcagggata ataataccaa cttggccatt tgctgaagac
4g21 cacttcctgg gcttactgac ttcaatgtgc agtttcattc atcctcacaa cctcctaatg
4981 aggtgcagat tatggtcctc ctggtgtaga tgagaaaaca ggcctaggga ggtggcacag
5041 aagggtacag ccgagcttga attcaaactg aacctgtgct ctctgcatca cagtgagatg
5101 acccaggagg atatcatgtt cagcctgcgg gcagggtggg gcagggcatg agcatggacc
5161 cctctgccag ctttgcctct gtggtcctca cctcccacat ctgcatccag aggaagaatt
5221 atgcttgcat ttgctgagtg cgttatacat catσtccttt aattcccagg tcctagccag
5281 gtactgttat ttgtcccRtg ttacagatgt ggtgacgagc tcacttgctg acttttagta
5341 gtggaaccag gatttgagtc tgtgtgactc tcta-tcctga gttcttaaca accatgcatt
5401 taaaaaaaaa atttatatat tattgcttat cttgtacacc tcatttattc actcattcat
5461 ttggtcRttc attcattcaa cagatatttg agtgrctagat tctgggcact ggttgtgaca
5521 gggtgagatg ggacagtgag tgtgaaagac tttggaagca gagtctctcc ccagtgtggg
5581 gttagggtgt agcctggtca tggtcattgc agattccaga acgtttgtgt aacaaacact
5641 catatggtgc atactaagtg ccggacactg ttc tggagt tttgcagtta gaatcactta
5701 atccctgtga caaccctggg attgttatcc ccattttgca gatgaggaaa ctgtggccct
5761 gagaagttaa gcgacttgcc ctggaggcag aatcacagat cagcatccct ccttccttcc
5821 ccgaagttgt ctcagattgt tccttcagaa agaaaaagag tcttcaggct tagaaagctg
5881 tgtcggatca gacaagctgt ggaaacggag ggttctgggc cctcctcctg cctccctgtt
5941 tctcctttga gagtcatcag tgtctgaaca aacaagtgga gtcctaagca gcctcattcc
6001 aggcagactt cctgtctcct ctcttatcag ccacttgcaa ggcaccttct ctctcccctg
6061 ctctcaaact ggaccatccc tgcaagaaga gacagctcct gttttcaata ataagaataa
6121 gaatatctga tatttattga acatacacta tgctaagcat tttatttttc tcatttaatt
6181 cccacaacag ccttgtgaga taaatagtat tatcagctct attttataga tgaggaaact
6241 gaggctcgga gaaattaacc aactcaccca aggtctcagg gttaatgagt ggccaagctt
6301 agacctaggc tgactgtcca atccagtggg ccctggcctc actctgttcc gtctcttagg
6361 gacgggtgtt ttatattctg tgtcacctgt ctctgtgttc actgttcccc tgaggtgtaa
6421 acacctgaaa aaaaccaaat ttgggttttt gcctcaagtt tgcgggcccc acagagttgc
6481 tggggatggt ggcagagcag ggttgggagc cattagtacc attatgggca ccaggttact
6541 gctagacttg gcctgggagc tctggctttt tgtcctctct ccttcctcct aacctcaggg
6601 gtcctcactg cagcatcctc tgctctcaga aggtgtaccc ctctccagta gctccctagt
6661 agctcctgag tccattctac ctcctttcta agctgggaac acatggaaga cttcccagga
6721 cagtggctga catgggcagg agaggaaagg ggcagggagg gagctggggt ccgcccaggc
6781 ggcccacacc tccttccaat tgctgtgccc agcattcctg cagaagagca gtcagggttg
6841 ggatgctgga aagagaggtt tagacttgcc cctcccctgg ccctgaccta gccgcctcat
6901 ttccacaggc agctggacca agggccttct ttttgtcggg actcatgatc acagggtgag
6961 ggttgggtct gggtccctct ccctcttgct gatgggcacc cagaaaccag gcattgcagt
7021 accacttgga aatggggaga ggggtgtcag aatgccaaag caggaagaga cacaggatgg
7081 gaaagcgagg ccccagaggc ctttgccatc caaacctcaa gagacaaccc atccttcccc
7141 ctgcttgtgg gccagctgga accacaggtt ttccaaaccc aacgcaaatc tttctgcaaa
7201 agaaaggact ctgggaatcg attccagacc ctgcttgaca atgaagtctg tgctcacaca
7261 ggcagtgcca ccagacgttt tatggagtat gggcattggc tcacgcactt gccaaggaca
7321 tacaggtgct aggccctgag ctgggcgtgg agaatttcag gggcatccca gaaccctccc
7381 tggcctcact gacgtctcag cctggcagtg agaaaacaga cacctggggt ggagagtggc
7441 ccaagtccat gtctgtcttt gccagctctc agcacccact gtgcacctgg gagacgtgca
7501 ccagaagctg agtacaggca aaagataata ccactcaccc ctgccctcat gggctcttgc
7561 ctggctgcag aaggcagata tcatctcgtg aggaaatagg gcagatatca tctcatgagg
7621 aaatagtcat ttaacaaata tttattgagc gacttactgt atgctgggca ccgttctaga
7681 gctgggtatt cattcgtgaa aagaaagaga caasattctt gcccttgtgg atcttctatt
7741 ttcatgtata aacataataa atatgtaaaa aaaatagaag gtactaagtg ctgtggaaaa
7801 atagagatag gtaaggaaga tcgggagtgt aggagaggga caggttgcaa aggtggtcag
7861 gcctcatgaa ggtgacactt gagcaaagac ttgaggcata tgagtgagcc atgcagctgt
7921 ctgcaggaag agcattccag ataggaagac agccagtgca aggccctgag gcaggagttc
7981 cctggggttt tcaggtgtgc tccagtgtgg ttagaacaga gtagagtgga aatggaggta
8041 taacagggga caggtcagag aggtaatggg gtccgggcca tggggagctt gtcggccatt
8101 gtaaggggtt tgccttttat tttctgtgca tcccttttac tcagcgtttg agctgagtag 8161 aagcatgggt ccctgactgc taaacagggc ccctgactgc tgtgccagga gtggacagtg
8221 gagagtcagc caggggaacc gacaggaggc tgttccagag agtaggaaga gtggtagcaa
8281 tggaggaagc cagctttagg gtatgttctt gagatagagc tgaggggatt tcctgctggg
8341 ttggatatgg ggtatgaaag aaagagaggt gtcagggatc acacagtggt ttatggctgg
8401 tgtggctgga aggatgcaat tgccttgagc tgagatggga aggctgtggg cagcgtaagt
8461 tttgtaagaa atatgaaaat ttcagS cac tgtgcagggc ctgagagggc aaggagggaa
8521 cccctggagt aactgaagca tcaagggaag cttctagagg tggggtaggg ggcaccaggc
8581 agggcctgca agggcgggga gggctcaggg gcaggggttg ggttcacgct gggaggaaat
8641 gtgcattagg tgtgcagaga ggcagcagag gcttggcctc tgagcaggga gctgacctcc
8701 gcattggtta gcattgtctg cctccccctc agcccagcct gcctcctggg cagctggcgc
8761 aatcaagcac acacttacaa atcccttctg tgagtcaagc ccttctgctg ctgtctctcc
8821 ccattggtgg Sgtggacagg tgagtgctgt aaaagggtgc agggtggtgg tggaggggtg
8881 ttcaggactg acagggtggg ctttggagct aaagactgtg tgcctctgca taggtagagc
8 41 tggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtacgcgcat gcacatgcat
9001 agctgggaat tccaggacaa gggcaccatg gagtcNgggg gtaaaaaagg ttggggtRtg
9061 ctgccagaga cctgcctact gatccttagg attaagagtt ctggaaggct aggtaaggtc
9121 aaaccacaga Yggctttagc tgccactctg agacttctag gcttgattct gtgggcaatg
9181 gggagccatt gaagaccctg ggcctggctt gatggctgtc ctagctctca ggcttgagct
9241 gggttacatc ttcattatgg ggcaaagtgg aatctgcagc caccttgcct gcctgctcac
9301 caagcaggtg tggcactgcc aggccagtgc tgacaagtta atttcctgat tatgagataa
9361 tcatttccta gggaatcggg cagccagctc ccgccgtgga ggcctctctg gctcatcttt
9421 attcaaggcc ctgctctgca gagctttctg cttctctgcc acctaggggc tcctctggag
9481 tctggctgcg ctagccaaaa catcccgctc agcacatatt tcacaagcaa ctgaccagtt
9541 cctcctggac tttgtttatc ctccagccct gggctcaaga gattagggct cttttgcatt
9601 ccactttcca tcatttgccc ctcatgagga ggaggcttgg agaggaaaga ttccagagac
9661 aaggtttact gaacccacaa aaaagaggaa gccaagaggg aaacaggtga ggtgtggacg
9721 agcaatggga aRgcagccac agggctctca gcgccaggca gcctccctcc aggaaccgct
9781 gggcaggagg gaacagattt ctaatgaagc aggaaggatt taggtcagaa ggtgggagaa
9841 tttcctgact gctaaagtat cRtctgtagg ggttgtgaga gggctcgggc tcttgcccaa
9901 ggctggggaa tgaactgaac agctcctaaa aagtatttta atctccaagt gtttatcgat
9961 ctatccaacc tgtgttcagg ggccagctag ttcagtctcc ctcatcatcc agatggggaa
10021 agtgagcctc agaaagggga ctggggagac tggacaagac agtgaactca cctctggagc
10081 ttcccccctg agaaggcccc agctgcatcc caccagggaa ggggcagatg gtctttgtcc
10141 tccggttccc gagggcgggc acgggagccg tcagcaactc cagacccagc Rttgagcagg
10201 aggacagggt gggcttgtcc cgagcacaca ggccccaaga gtcagtgtga caggttcctc
10261 ctactgtgcY cctgcacact cccacagagg aagctccagg ggcagagcca ggatatagaa
10321 cattggttct gtcttctcgg ctccgtgtct tcactgtcct ggaggtttga agggcatgct
10381 atagctaaaa ggcttacccc acatcagtgg ctggctgtct ccctgtggaa tgaatggccc
10441 tgggaccgta ttccctcgca cgcagctcct ccccagccga gcatcctggc tttggccatc
10501 tcaagggtct tcgctgcccc gtgactcagc atccctgcca tcctggccca ggctctgtgc
10561 agcctgcatc tgaggaagaa tgcccacaga ggccggcaca gggcctcagg ccccgagtca
10621 ggtggaggac aattagaagt ggaagaatgg aggccatgaa gcctgaagtg gggctgggtc
10681 aacccaaggc cacacagaag gcctatgaca cagtagggca agaccccagg ctcctgtctc
10741 cctcctggga gcaagaaatt gatggtggcc agggttttcc tgggtagtct gagcaagccc
10801 atccacccag tctttgggtg gtgagacccg ccccagccta cccccaccag tggtgctggg
10861 ggcttgggag aagactgagc agggctgtag gtgacccagg gagctggctg cgtaccttca
10921 tcaggcccag gaggggcacg tacggccgtt cactgtagcg tgtttgtgga gcggggagtt
10981 agaggtgacc tggaggtcta aaacaggagg ctggccgggt gcggtcactc acσcctgtaa
11041 tcccagcact ttgagaggcc aaggcgggtg gaacacttga ggtcaggagt tcgagaccag
11101 gctggccaac atggtgaaac cccatctcta ctaaaaatac aaaatttagc cagagcacac
11161 acctgtaatc ccagctgctc aggaggctga ggcaggagaa ttgcttgaac ccgggaggtg
11221 gaggttgcag tgagctaaga tggcgccatt gcagtccagc ctgggcaaca gagctagact
11281 ccgtatctat ctatctatct atctatctat ctatctatct atctaggtag atagatagaa
11341 caggaggcca gctagaaggg acatagagga tgcacatcgt ggaatcctat gtagcagtga
11401 caggcagtga actagataga ccttaaaagt ttacatggac tgggctcggt ggctcacccc
11461 ataacctcag cactttggga ggctaaggtg ggcagatcac ctgaggtcag gagttcgaga
11521 ccagcctggc caacatggtg aaaccctgtc tctactgaaa atacaaaaat tagccaggca
11581 tggtggcatg cgcctgtggt cctagctact tgggaagctg agatggaagg atcacttgaa
11641 cccgggaagc ggatgttgca gtgagccaag atcgcaccac tgccctccag cctgggctga
11701 tggtttcccc tgtatttgga gtaagcaaaa agacctcatt tgactgggtg cggtggttca
11761 cgcctgcaat cccaggactt tgggaggctg aggcaggagg atcacttgag cccaggagat
11821 caaggctgca gttagccatg ttcacgccac tgcattcctg cctggacaac agagcaagac
11881 cctgtctcaa agaaaaaaga aaaggtggag gtggcgtggg gagctggata tgtaccttca
11941 ccaggtccag gatcttcctt taaaatgcat actttttgag gtgagggctg atcacacagt
12001 ctgataataa ctggacttca cccaacattg gccactctgc ttggagggcc tgttgtaccc 12061 tacaagccaa aaattgcaga ccagcctcct tactcctaca ctgatcgtgt ccactagccc
12121 ccaactcaat caacccttct ttatcccctt ccaacatcac ataatccccc agccccaagc
12181 cctgcagagg ggccaagagc ccaagcctgc aggcctggct gctgacgaaa tgtcccctgg
12241 gagagctgcc cagagaagga gccattgttc cttcctggaa aaacatacca gctatgggag
12301 ggggtctgct attccctggg acctcggcaa ggatcctgag ggtgaggcgg gggggcctgg
12361 cctgaactcc tgaggctgct cctttccagc agcttccccg agctgctgcc tcttgtgtca
12421 cccccatggc catgagggtg tgacagaggt ggagctcaga gagggagtca caggaggccc
12481 tggtgattgt tagagatgta gaacaaagaa acttacaaaa taatggtaag agtgattcca
12541 tttaagttct agaaaaggca taactaatct acagtgatta gaagcagagc agtggctgcc
12601 tggggtggcg gaggcgggga gaggacttac agggaagggg ccagagggtg acagaaacaa
12661 tccacagctt gattgtggtg gaagccacac ggctttatac atttgttaga acttatcaaa
12721 ctgtacacct aaaatctgtg catttcactg tgtatagagt acagctcaaa aagtttattt
12781 ttataaaaag agtgacagga ggagtcctgg gagggcaagg agacctagga tctcctcctg
12841 gggtacccca gctccctgtg tgaccctgtg cagatttatg ggcctgagcc tcagtttcct
12901 ccggtgcttc caaagacatt atgtgccttg gtgtcttggg ggcaggacat ggaaaacact
12961 ttgggttgcc tagaacagtc attaaagagg ctctcctgac agagcctgag gggctttgga
13021 ccagtcagtc accctcaaaa caaaagttgc tccactgagg gcgagtagga ctcagggcct
13081 gcccatagaa tgccatctgg agcggaggag acacacacag gttagtatgg tgaaatctaa
13141 gtgtagatca atacagatgg ggtggtgaga gaggagaatt ttgtgcagtc tgagatatca
13201 ttgcaatcag gggagacttc ccgcaacaag aggcccctgc ctgagcctga gattcctcaa
13261 cagtaagagg aagaagatga tcatctgtag cgagggtcaa ggctcagatt gtgaccagca
13321 gccccaagct gtttgtcctt agtctctctt ccaattctcc acatgcagta ctctacaaat
13381 gcccctcctc cataactctg gcacttataa ccctactcca ctcagtttta atcagacttg
13441 atgatatcac agcaattcct gttttttttt ttttccttta gctgaagagc tttagtccat
13501 catcagggga caaacagaaa tgagactgag attcagaatt gctgataggc atcagacctc
13561 cgtctgtgac caggatcagg gctcggtgtg tgaccagcat cgggactcag actgggatca
13621 ggaacagggc ttggtgtgtg atcagggtca aggctcaggg tgtgcccagg gccagggttc
13681 agtatgtgac caaggtcagc gcttaatgtg accagggtca gaggtcagtc tgtgaccaag
13741 gtcagggtgc agactgtgat caggcacagg gctcagtgtg tgtacatagt cagggctggg
13801 agaggccagg aacagcattg gccctcactg gccccacctg gcctcttcct cccgctcctc
13861 caacttccct gggttgcata gccagctcat gaaatagcct agataggaag ggtcaggcca
13921 caaaagcttt gtggagccat ctgtgcagta tttcttgaaa ctgggcctgg ggtgggggca
13981 gcaagctgtc tgatgtcaaa tgctgggtct cctgagtctt aaggcccagc taccccaccc
14041 tatacgcagc tgagggaaag gcactgggtg atggggaagg ggcccatccc tctcatcctc
14101 acccctcccc cagaggcttc cagggtccag agagtgagaa ccagctccca gctggcttga
14161 gggcctatgg gtcccttggg aaatgactgc aaacattcct aggggctcaa gtaacagggc
14221 ctaggctggc caagaagtcc cccaccagcc aggagccacc tcatcctcac ccacccttgt
14281 actccaagct tcctcatcat tccaagtagg tgagatcacc ctggctgcct ggaccaggct
14341 cccccatgag gcccaggccc cagggagagc aaagctaggg tctgggaact cagggtggtg
14401 tggggtgggg gatatgctgg cagacacttc tgccgatggc ttagaagcca gccttcccct
14461 ccttggcctc atcttccaga cctaaaagct gatgagaggg tcttggcagc aggaaagggg
14521 tgggaaatcc ctccatggga ct caagtcct cccaccttgc ctgctctcac ccttcctgaa
14581 tccctcaaga gcagaggact tcaaagaaac taagaggagc ttacagcctc atcttatcac
14641 ttacctgaca gaatccctga ggccagagag gagacggaat tagaggcccc agaaccactc
14701 ccctttaagt cagtggctgg gc tgggatag agcccagggc cctggagtcc cccctgccca
14761 cacccactgc tgcccgcacc caccccagcc cacaccccat cacgaacaga ggagatattc
14821 cctcttcatt ccaatgcaga atggagtctg gacacctaag tttggtttct gcttattcct
14881 agtaactcct gctcagactc ctgcatgccc agggaggaag gtggaggggc aggaacagga
14941 cggacaggcc ccgggctctg gcacatcctg gggaacaagg gaccacaagg acgggggcag
15001 tctccagact tcccctgggc gcttgacccc aggccttgca ggggagagag ccagggcctc
15061 cctcaggttg gtggccggag gt tgcagaca gaggagggtg tggtcaggtc tagggtgatg
15121 atggcaggaa gtggtggcag gtgatggggg gcgggggtat ggggaggagt ggctgcacca
15181 ggcagaaagg aatcctgaga aggtcaggct gggtgcccag gctgagaatc ctgccctgtc
15241 agcagcctgc tctggggaag tgttttcctt ctagcccatc ccttcctgcc caccctgact
15301 cctgccagcc tgcatccacc tggctctgcc catgaacctt cagggacaca ctccaggcca
15361 gaagcccagg gctctcttgg tggtttacaa agaatgctga ctgcagggat gagaggaacg
15421 gagggtgtct gggggctgct gt ccagaggc ctggggagta aggactcgag ggagtgcctc
15481 tgtcaggaaa ttacatggtt cactcattcc tgcctccagg tctttgttca tgctgttttc
15541 cctgccgtgg acaccctttc ccgctctctg attctctaaa tcctgcccca tctcccagat
15601 cttgttcatg tccaagcttt tccaggaagt cttagcagct cccacaccgc agagctcgag
15661 atgtaagctc ttgctgcctg acttccctga ccccacacct gggcccagga cctaacaccc
15721 aaggagaatg gcaaagggtt ttggggtatg agaggatgtt tggggtgtga ggaggtctct
15781 gggcattagc agtggccaac ctgatgctct caatgtcatg ctcttcctcc ctcccccctt
15841 ctctcccact gcccactcca ggtctccctg acttggtccc agaccccaac tatgtgcaag
15901 catccactta tgtgcagaga gcccacctgt actccctgcg ctgtgctgcg gaggagaagt 15961 gtctggccag gtaaggagct gaggcagaag tgtagagtgt tgggatagtc cccgggagtc
16021 acccagaacc cagcctagct gtggctgcca gctaggctgt ctgcaagctg atgaccctgg
16081 ccaagtgccc cagcctccca ggaccctgac cgtttcatca gtgagccttg cctgccccga
16141 gggagtcagg aggggagggg agcaagYggg ggcccagcat ttctgtatac tgtacctcac
16201 tatacaagga actccacttt tactgtggca cttcatcttt atatgagccc tgaaggcatg
16261 ggttaccccc tcaggaaact gaggagcaat gaaaggaact caaacctttt ggatctgagc
16321 tgtttaatga gaaggttcct tttgg-gagcc caggcttcca gtggtcatac agggacccaa
16381 ggaagtccta ttgggtggat gtacctgcag gatagagccc aggagtatgg agccatgtcc
16441 acagaggaca gttgtggctt tggctggtcc aggctgcctc tgcctagtca cagcaggggc
16501 agtgagcccg ggggacaaag aagtttcagt tatatgttgc actggaaaga ggggaaggag
16561 accagtttcc atgaacctag aaggtgagca cagctggctc gccattattc atgggtgatc
16621 ctgcctctcg cagtgtttgc ttctaattta taagcagttc atattctgct ggaacatagg
16681 tgctttgcgg atacctccct gggccaaaat aattagttaa gattatgtta tctgcttctt
16741 ttgttaatat ccctttatgt tgaaagcacc tatttttctt aattacctgc tttttggaca
16801 tttgaactct ctgtttagtt tgacttttta ctatctagga aactctttag aatctcaaca
16861 ttttctcatt tctagaactt ctagttcact gccactctaa gtagctgatc ataaaccctt
16921 atctgtctgt aacaagataa agagcttgaa ctagaatgta actcaactca ctccttcatt
16981 gagaaagtct tgctttaaaa aaagaaaaag tatccgctga actaagcaga gtgattagga
17041 atgttgtcga tgtacattct ggtgcaagtt cccaatccca tcccagactg gcatcagtgt
17101 gggaactgcc cctggtccag ggacσgcagg ctgagtacca ctcagccagc ctgtctgggc
17161 agttcttgtc ttgtttcagt tgtcttgggg aagagagcat aatggtcctg ctggaattcc
17221 tccagcaatg aggaacttac agcctccatg acagcccttc cagtcttaag agaattagtc
17281 aaagtcaaac tattaacatc actgcctctt catgaaggat cctgagtgcc cggacctgcg
17341 ctcccagctg gggagaggag gcagcctgtc ctctgtcctg gagggtctcc tggtacagct
17401 ggagagaaca gccctcacct gtaccccagt gacagaacca agacacgagt gggaaaagag
17461 ccagaaggac tggttcacag gccagggctg ctggaggtca gaggagggag ggatcagcaa
17521 gggctgaggc ctcagaggag gtgggcgtgg gagttcagac ctggagaatc ctgcaaaact
17581 ggagccctgg ggcaggaggg ccctσtgaga tcatttcaaK tatgggccgc aggctggtgc
17641 cagttcacat gctgcaggca gaacccagag aagaaaaggg accaattcca agtctcacca
17701 ccagtttgtg gccaagctgg gcctagaacc tagaccctta tggtttccca Yggtgtgctg
17761 agcYgaacag aagggcagga tttaacYgaa cagagggaag gaggatgttt tgtttcaacc
17821 cagacataga cagattccaa gcctccccca gacaaggctg agggcctttc atcctggcag
17881 acagtctgag ccgcctgttg tccagacatt ctctcaaaga gagcgctaat ccctacgact
17941 ggccaccgct cccctctggc cttaggatcg gaccttaatg agtgccaggg aagagcccct
18001 gaggccaaca gagttagctg tcagccgtca gctaaagagg ggaggggcct tcagccaccc
18061 cttcctgttc ctaccacaca tgtgtgtgca tgtgtgtgta tgtgtgcatg tgtgtgtgtc
18121 tcccctcact gcagcccctc gttcctcttt ccaccctttt ccttttgtca caaggcctac
18181 ctcagttgga aatctggagt cagcaggtga cttgcgagca ggcaattcat accagaccca
18241 tgttccctga atggaaaagg gcaggttgcc agcctgaagc catgcaatca gggagaggtg
18301 gtctggaccc agtgcaagat gtagatggta tcgggctgtg ctgcagtcag tgctgttaga
18361 gctcacaggc aatccggatc ctctatgtag agcaatcagg gcagacttcc tggaggaggg
18421 gacttttgag ttgaccctag gatactgggt gagttttgga attctgggtc aagcaaacag
18481 catgggcaaa agtatgggtc agggaaaaag ttcagcctgt ttggaaaata ggctttgaag
18541 caggaaccca gggtgtgtgg gggagtggaa gggcagatgg gactagaaaa gtgaagaggc
18601 tttgaccaga ggacttcacg tctgtttttc aggcccacac ccaagacatg gcatactttg
18661 gtcaacaatt agggctctgt cttgttgtca gagacttatc agaatctcct ggataggact
18721 tttttttttc ttttttttag aaagggggtc tcactctgtt gcccagactg gagtgcagca
18781 gcacaattat agctcattgc agcctcaaat tcctgggctc aagggatcag tctccaagta
18841 gctgggacta caggcataag ccaccttacc tggctaattt tttaattttt taaaaatttc
18901 tttaattaaa ttaatttttt aaattttaat ttctcactat gttgcccagg ctggtctcaa
18961 actatgggcc tcaagtgatc ctcctgcctc gacctccaaa aagctctgta attacaggca
19021 tgagccaaag tgcctggccc ccgcaatagg gctgtttttc agtggccctt cagagattgc
19081 tatgtgctcc tgcacctagg ggctgacccc agctgagtca cctgcaggta tcagggacac
19141 tgccatgctt ggtaccgctt tagaaagatg ctgttggcag ctggcggcca catggtggag
19201 gccagaaagg aggggacagc caggatttca cggggtcaga agacagagga agaggcctga
19261 gcctccgcca cagttcgagg agacagagga gaagatcttc agggacaagg agtggggctg
19321 cagaaccagt ggccaagggc tgggggtggg gctgaggggg cccatgctgg gttctggtgt
19381 cactgtgccc caaccccccc Ycatctcccc cgccgtccct gcagcacagc ctatgcccct
19441 gaggccaccg actacgatgt gcgggtgcta ctgcgcttcc cccagcgcgt gaagaaccag
19501 ggcacagcag acttcctccc caaccggcca cggcacacct gggagtggca cagctgccac
19561 cagtgagtgg ggaggggctg ggcccgtcct cttccacttc tcctctgggc cagggacctt
19621 ggtgcctgag ctcccctccc accatgagca ctctgggaga cacagatact ggattagagg
19681 gcccggggag gtgttacctg ccaactcttt tcactggggc aagtgtttct cagagaagcc
19741 ttagccaaag ctaggctgga agatggatat agaaggattg gtctcaatca gggatggaaa
19801 tgtctagaat acagggcatt gcccagtgag gccattacag gtgggagccc aaaaaggaag 19861 tgaggggtct agagcatgtg ctgtcctgga gtgacccagc taggtgggga gcacagaggg
19921 gccaccccgc agtactcagg agacaggaga acctagacca gccaggaggc tgtgccacag
19981 cagggtcacc tgagcccatc tcaggatggg gacaggatga gaggcccagg gaagactagg
20041 ccctcttc tctccttctc tcctctgccc ctaggcatta ccacagcatg gacgagttca
20101 gccactacga cctactggat gcagccacag gcaagaaggt ggccgagggc cacaaggcca
20161 gtttctgcct ggaggacagc acctgtgact tcggcaacct caagcgctat gcatgcacct
20221 ctcataccca ggttgggctg gagagatggg gtttggggca tgggaggata aggagttggg
20281 gaggcaaaga gcgaggcccg ctgaggcccg gcaagtgcca aggcttctgg ccactcagct
20341 ctgctcacag tgaaggtctt ctcaccagtc ctcaggctgc cacactgccc tgcagggact
20401 gttccctccc tgccccagcc cctttcccat gttattccag gtgatctgct cgtggagaga
20461 aggaaacatc gcaacagtct ggagagcaac acgtcctatt ggcctgttca cccaσccata
20521 tccctctttc catcagccac cctaaatatc cacaaactgt ccatctgtcc tgtctctttt
20581 tatccattσt gccatccatc tcgtccctcc cacctggcta ttagatatct gtctttcctc
20641 tggtccatσt agccagtggc tttaggaagg tgtggaccca ccctgagcag ttgccctggg
20701 ccagggtcag gggagaaacc caggggaagg tgggccagaa actcctgaag gtgggcgtgg
20761 ggtggctctg ggaaacaagc agcatcacag ccgctcctct tgtccctttc ccagggcctg
20821 agcccaggct gctatgacac ctacaatgcg gacatcgact gccagtggat cgacataacc
20881 gacgtgcagc ctgggaacta catcctcaag gtgggcctct gggtctgggg ctttccctcc
20941 aacctgatgt tcatgtccaa tgtccccccg ttcctgaaag aagcttcagc ctctgggcct
21001 gttcccttct ccccagctgc Mgagcagagg cagcatctga ggcatcactt gaggtttagg
21061 cttcccagcc gaagatttag gtctcaggct gacatagcct ctctttccat aaagaaccca
21121 gggaaccttt gccccagctg tggtaatgcc agaggcagtg gtgatactgt ctccctaagt
21181 gacagaggac cagggagagc aagaaagact tggagagcca tgtggtctat cttcctgtct
21241 tcggacaggg cagactttgt atcatttggg agacagatga gaggccctca gctccttata
21301 gggacccctg caaagccaag ggctcctgtg actaagaccc ttttagcctg aacccctcct
21361 gctctaatgg acactcactc catcacctct tcccttggtt gagggaaaag tagaaaagca
21421 tattaacaac acacatccag acttggtaca tccgtgtagg ccaggttgtc atgggcccac
21481 ctggggaagc catgtctcag cctcctccac acaggtataa aatgagtagg gatcattcca
21541 ccagttcatc tggacccact cagaagcaga aaagcagctc agtaaaggca gagcagtgaa
21601 gccaggtttg caggcggagg ccttccctgc agaaagtcag caggtggaga gatgcatccg
21661 gcagcggttc tctgcagttc cctcctgagt gctcttcagc aggctccaag cttgctcctc
21721 cagggcctgg ggttgtccag tatatttttt cttttcctca ttcatccact caatcaacat
21781 gtaggaagtc ccctctgagt tctaggcact agacacacaa accacataag caatgcagtt
21841 cacagtccct gccctttggg agtgtaccag gatttgaaag ttgcatccct gcatctgttc
21901 tYagatgttc tgcaaataaa gctggcccta ccctagttaa tccaacattt aaaagtgttg
21961 tatcccaaca gctccttttc agacaaaaag cacagatcat acttgggcca tcatctcagt
22021 gaatgttggg cacgtggggc tccagagcag gggatcagac aggccctcga tcagtcacct
22081 agacagggat gcatagggaa tgactttgag ccttggattt ggggagacca ggtgttgaat
22141 cctggctcag ctcctcatta ctgcattccc tcRggcagga tccaacctct ctgaccccaa
22201 atgccccatg cggggcccac ctggcatagg ctctagctct agggaaacat ccaatcttct
22261 gataaggggg attagatgat gttttcttgg attaccagct gcctcttctt tcccctctgt
22321 gtctctctag cagtgtgtct ctgttctccc tctctctgtc acctctctgt ctgtctgtct
22381 gcctctttac caccttctct ggtgagcagt tgaggYgcag cccccctgac tagactccct
22441 ttctccctgt ttctcttctt cctcaggtgc acgtgaaccc aaagtatatt gttttggagt
22501 ctgacttcac caacaacgtg gtgagatgca acattcacta cacaggtcgc tacgtttctg
22561 caacaaactg caaaattgtc cagtaagagt ttgcccacca cccttcctgg ctccgtccct
22621 ttcctgcctg gggagcaggc aaggccacct gaRataccta agatacctgc actttaggtc
22681 accttgatgg ccgaacgcag ctgcagcagg gcccatcaaa aagagccttg tccgtgccaa
22741 ccccaagctg agtgtttacg gtggggctca ggccgtaggg tgttgatctg gggctgcatc
22801 ctgtggctcc ctgagatgtc ccaagtgaaa accagcagaa ggcagagtca tttgatgcaa
22861 ggccatgagc tctgcagtcc cagttccaca gcttcctcgc tatgtgacat tgggttactt
22921 ccctgagcta ctttcctcaa ctataaaata ggtatttcca cataggctgg caatgaggat
22981 ctacaggcct gatgtctgca tgttcacagt ggcacacagt gaacagcagc tgtgatcatt
23041 agtgtccttt tcaagtggac tggattaaac agtcacagat tagaagtgat tctggttcaa
23101 aggagccatc ttcagtccct aggcccccat tgtagaagaa gtgcctaaaa tctgggcttg
23161 ggattttggc acatgctgct gggtagggtc ctcagtcttt ctcctgattc cccatgtgaa
23221 gtagtttgca gagggacccc ttgcttacaa gctcacaagg aaaccccacc acactccaga
23281 tcgaagcaac ccttttccat taaaaaaaaa aaaaaaaatt agtcctagag ctttcagctt
23341 tagttcatca actgggagaa aggtggtaga gatcttaagg cccagagagg tatctttccc
23401 taaaagtgtg tacttattaa tggatggcag gtatgagaga ttaagcctat gactatggtc
23461 agggtgtggt gtatggccag ggtcaggatt cagtctgtga caagggttag ggctcagtgt
23521 gtgacaaggg ttaggactca atgtgtgacc aggatcaagg ctcagtgtgt gaccaggatc
23581 agggttcagt gtatacctag ggtcagggcc cagtgtgtga ccagggtcag ggctcagtct
23641 gtgaccagag tcagggccca gtgtgtagcc aggctcaggg ctcagtgtgt gaccaggatc
23701 agggctcagt gtgtgaccag gatcagggct tagtgtgtgg ccagggtcag ggctcagtct 23761 gtgaccagag ccaggctcat ttagagacag ccctctcaca cttggttgct accatcaacc
23821 taactgttca cagcatgctg ccaccacatc atgaatatta aaaatgggaa cagcagcctc
23881 cagttcagtg cagagattag gttcctcatg agtagaatga gatcagaatt ccccagggca
23941 cacagcatgt ttgaaaggac gaactcctgt cccatcactg gcagtttggc tctttagcag
24001 gcctgggttt ccagcacatt cctgctcctc agggcctgtc ttagccattc aagacccagg
24061 gtcacctaag tggtagaagc cattctaggg aaggaggagg aaggaagaag ggggtatcca
24121 ggaaacaaag gaggctgctg ggggctcggg gaggcaggga atccctcctg ctgctgggaa
24181 agggggatgg gaacagaaac agcatcccac gtgccaggcg cctggagcag ccaggagggc
24241 tgtcggcagg gcagatggag aagcagcctg cgcggccctc ccagctcccc gggggcctgt
24301 gggcagcagg gggagccaaa gcccttcctt ccaagagctc tttacataag tgcttggaaa
24361 ggccgggcct tattagagtg tctcagtctc tgtgaccctg accgcaggca ggcagctggg
24421 ccagcgtgca caggaagctg gacagagcgt tcccagaaag gccacgggac tgacgcctgt
24481 gggtttccat cgtgtttctg gaggaaaaag gaggcttaaa aaaaaaaaag tactgagtta
24541 gaaaaaacaa gaaagtattt ccagacagta gcagctctgc taatggccta gaaaacaatc
24601 tgggactagg gcatggggag gggaatgtgc tgagactgtg ccctgggtgg gtgggagtcc
24661 atcaaacccc tccttttgga gctgggctga gggggtcgga actttctctt gagggaaatg
24721 taggcccatg cctgccctgc cacgagggat ctgggctgtg ggagggacgc cctggctgag
24781 gaggccacgg gggcctactt tgcagcccct cattgaccca ctgtctttcc ttcctcagat
24841 cctgatctcc gggagggaca gatggccaat ctctcccctt ccaaagcagg ccctgctccc
24901 cgggcagcct cccgccgagg ggcccagccc ccaacccaca ggcaSggagg ggcatccctc
24961 cctgccggcc tcagggagcg aacgtggatg aaaaccacag ggattccgga Ygccagaccc
25021 cattttatac ttcacttttc tctacagtgt tgttttgttg ttgttggttt ttatttttta
25081 tactttggcc ataccacaga gctagattgc ccaggtctgg gctgaataaa acaaggtttt
25141 tctactctgt ggctctgcat gcggcctgct ggctggctgg ccagccacag ctagtttggg
25201 cctgggggat gtccttaggc atcatccttc ccctcgccaa atgtggaaag ggcagccacc
25261 acccggtcag gaccacagtg accatgaggg cgctgagccc atcgtggaag cctgtggggt
25321 tgagcccttg gccaagcctg tcgcatggga atgggaccac atccgactag gggagggccc
25381 tgcagcgggg tgggcggcac cagcctgctc tccctgctca gcccctgctc ctatctgggc
25441 tcgtgtgccc actgctgccc cttctcagcc ttcagcctca cactcccacc ggtccccctc
25501 ctggccctct cactctcaca ccgttcactc tccaccagcc acccactccc ttacaattgc
25561 aggctcccga actcaagtct cctgaaggcc aggtgctgtg ctagggcaca cgcaggagca
25621 tcgtagcttc tgccctcagg gagcgcataa ccacagggaa cggggagcac gcgttgccca
25681 gtgaggc gc acctaggggt tctggggagc cttcacatgg gagagagcct ccttccaggc
25741 agggagggga gaagaggatt cttggcagag agacagcatt gagcagagat catgaggtgg
25801 ggctgcaggc cgacagggtg tgagtgggag atggagggag gccccgcagc cctgcagccc
25861 ccgtcccctg ccctggctgt ggcatcccag aggtcctgga cactggaatg gaccaggaag
25921 aagtgagagg gtggtgcctc tcctcctcga ggccctgaac aacgagccct cgggatgcct
25981 ccagacccac ctgcttccct gtgggggcaa caccagtgag aaagggaaag agactttgtc
26041 caagtaccag ggctctgggt tccagggcca atcctgctca ctgctgtgtg actgtgggca
26101 agtcagactt catctccggg cctcagtttc ctcatgagta agatgggaat gccctcctgc
26161 ctggctccca cactgacatg gagagttgat gagctactgc tgcaggggag gtgccggggg
26221 agctacaggg tgtcagcacc cacccctcca gatcttggtg agccccagcc catttgcaga
26281 ggtcctccaa gaaggtgtcc cctgcttttg gctctgatgc gatccttgcc tcagggtccc
26341 tggtagc ag gaggttttct ggtgcagtag agagggaggg cttcttggag ccatgctatg
26401 catccaggag ggttctggcc cagtcccctg gagcccttgg gccactcacc agcccaggca
26461 gcagggtgga gtgggtgtgg ctgcagccct ccctcggccc ttcctctgca ggtctggctg
26521 ggatttaact ctgctgacag ggtaggtgcc gcagctctgc cactctccct ctggagctgg
26581 accaggacgg gtgagaggag tacaggcaca tgcctgtcat ccagggctgc cattctgctg
26641 catcccc tgc cggtgtgtgc ttcccaagat gctgtcctta ttgcagcccc accccctctc
26701 cttcctagat actcccagga gtgagcttgg gagggggtca gacaaggtca accaattcca
26761 gactgtcagg aggcccgtat gaggtagaga caaaagcccc catttctcag gtcagaaaac
26821 tgaagcc tgt ctgagaccac aggcaagttc aaggcagaca cagtgctgga gctcacgtct
26881 ctaagcccta ggccagggcc aaatgccggg tgtgtgcagt tttctgggga gatctgtacc
26941 ctcagcagat gagctatggc cctgaacaca gaattggatg gaaggagaga gtaagggtgg
27001 cttttccaaa aagcccacac atcacaaagt gtggggaggt ggggagcaca caaggagact
27061 cccagacaca gtgctcccgc gtgcccatga acctttggcc tgaagttcag attctagggg
27121 ggctggtgga tgtccccaag cctgccatca gagtgaggac acctgggcca gtcctcacat
27181 gctgggagga ctctgagatt agatctctgg ggaggggctt cagatacccc tttgcccccc
27241 aaaaagc ga ggaggctttc acccaaagga gaagagagat agagagagaa gagagaagac
27301 agccgtgacg cgcagggacc agggcagccc tcaccgcttc ctggctgacc tgtcagggcc
27361 ctatcagtgc agcttcacgg cactgcccag cagtgacggc ccctcgggaa aggagatgca
27421 gctgctccca cctcaggggg cagggtttcc tcaggtattt tgactccatg tagaatggca
27481 gagtctccct gagaatgggg agagaaaaac tgtcaagacg gcaggggccc agcaggcgct
27541 gagctgagga gggcggctgg gagaggagtg ctctcccagc tcggcctcag cctcttgagg
27601 tctgtctggc tgtcactgca tggaggaaca gcctgcttgt tccttgttct tgctgtcacc 27661 tggctcgggc ccctccctag atagagctca cctgttgggc tcaccccacc aagccaggcc 27721 cagggagggg tgtgtgaggc ccactggagg ccaggtcacg tgacgcaggg actcaggccc 27 781 actggtccct tcacccttcc gtttgcccct tcaaggccag ctgaaacccc gatttctcga 27841 agccttcctt aaccatcccc tctccccttc aactggggtg cactgtgtgg cctcattcag 27901 gactctccca cccccaccct gccacggaca cacaggggca tgggaggagg cacccgagcc 27961 ttgcatgctg gacaaaggtt acataggtgc catctcagcc aggtgcagtg gctcacgcct 28 021 gtaattccag cgctgtggga ggtcgaggcg ggcagatcac ttggggtcag gagttcgaga 28 081 ccaactggcc aacacggcaa aaccccatct ctgctaaaaa tacaaaaatt agccaggcat 28141 ggtggcacgc gcctgtaatc ccagctattc gggaggctga ggcaggagaa tcgcttgaac 28201 ccaggaggcg aaggttgcag tgagccaaga ttgtgccact gcactccagc ctgggcgata 28261 gagtaagact ctacctcaaa aaaaaaaaaa aaagaaaagc aaaacaacaa caacaaaaaa 28321 accataggtg ccatcttcac tcctgaccca gcacctcctt ctgggctgca cagaccaaga 28381 gggtctctgc tggtacactg ggcactggtg tgcaggaatc cacctgggct gtaagggcct 28441 caagtcacct gcccagcatc cctccctgtc ctcttcttgc tcagccccag ggctggggag 28501 ctcactgctt ctcgagacat ttgctgttag aaacaccttg aggtgaaaca gacccccacc 28 561 ccYtgccccg cagccttccc ttgggctggt cctcggggtc tactaagtaa atgactctgg 28 621 tggatgtgac tggacagcag gaaggacaga gacagcagag gcgacacctg gcagggggca 28 681 cagctgtggc cctgactctg tccttcagtg ggcctcagtc tccctatctg tcctgagggg 28 741 gctgagtgtc ttgctagtcc ttacctggca gagaagaagg ggcaggggaa gagaagagag 28 801 ggaggggagg aaatgggagg tagaaggagg ctgggtaggg agtgataggc aaagtccagc 28 861 ctgggggaag gtgggcaagc agcaggggga ctgcctcaga aggggagcag ggagccagca 28 921 gaggcactgc tagggctgca gcctggtgag ggctggggcg ttatctggct tggaggatgc 28 981 cacagagaga ggcctgaagt gggggtactg gacctcaaac cagggctggc ctgaaaccct 29 041 tggaagggcc tgctaataga gacagaggtg ccctgggccc ttggcagggc ggggtgggct 29 101 ctgaaagcca gcccagacct gacccctctg cggcctacca tcttggccac agccttgacc 29 161 ttctccctcc ccctgcacct cagatgccca caccccctgt gcattacact gtgcgctccc 29221 acccagggca gcagccccct gcagggaggg cccaggctaa aatcccaccc attctgtttc 29281 ctctccttcc actagaatcc cacctgtttt gagaagttgg cagggcctgt gttagggaag 29341 cacctgataa ccaacgtgag aatggtggcg ctggtcccat gtcctgtctc acttttagat 29401 gaagagcttc ttcatcctca aaaaaaatga ctcagaagag agccctttaa tagactgctc 29461 ggctaggggt ggagggctcg taaggatatt tacagatcct tgaaaacaga gcttccagca 29 521 tttaaccctg aagagagctg gagcctgggc cccaactcct taccccacct gagcctcctc 29581 tctgcactgg aggcctctga gcctgactcc gcgcacccca cgctggccca caagccaagg 29 641 ctccttctga tgccccctga ggctgctggc attggccagg gctccatcag cacctccttg 29 701 ggtggggggg attaccgctt tccctactta ctccagcctt ggttaggggg cccatttccc 29 761 agctcctgcc aggctctcca cccatttgtg gtcaaggcaa gagagaccac acccccttga 29 821 atgtccaggc actgagtccc tgccggctac tcatacggat gggccctccc cagccattcc 29 881 tcaccacggc tgcgtccgga tccacaccac aaccacagca ttgttggaaa gcaactgcac 29 941 acctccctgc aacttcccct cgcatccccc agactgagtc atgcaggcgg tgcccgtggg 30 O 01 cagacctggc cagggttggc accagctggc cagagagaat gagaggcact gaccacaccc 30 O 61 aggaacctcg ctaaagccca tgcataaggg tcaggagagc agccagatgc tgggacccaa 30 121 gggtgcctgt gacacacacc accctgaaag ttgcagctga gcttttctga gaaggatggc 30 181 aaagtcctgg aaaagcttta acgacaaaac tcaacatatg gaaggcagag gaagcaggta 30 241 aggattctgg tctcctttta tgtgaaatag ctttaaaaaa aactttttca aaatcacgtt 30 301 taatatgcgt tgagccccct ggctaccagg tgggaaagtc aaagtcctga atcatttact 30 361 cccaccctag acaccttgaa cttcagaact tcagagagga gtcctgtggt ctttagtcct 30 421 cctggtcacc gctccctggc tgattcactc tcctccaggg gcggtgtctc cacttcctgc 30 481 aaagcttggg cacatgggca gccatgtccc tcgaggttcg ccacctcccc agggcactgc 30 541 caggaggcac tgtcctcgtt actagcagag ccagagccac caccacaacc atagccacca 30 601 cctccccagc ccagggaact ctcccagcct ctttcctcgg cctgtcttca ctcccttcta 30 661 actactcact cttttcctct tcctctctgg ggcaaccttc catcatccct gccatgtgcc 30 721 ttggttcaag gaatcagctt tggattctgg cccttaagat gaggagtcac aagtacctcc 30 781 taggaatgag aaagaggaaa agacctagca ggggaatgcc aataatatta gtgacactca 30 841 ctaatttctt caacacttag ccatgggcca ggccctgctc taaatgctct acaaaggtta 30 901 agcccattta atcctcacaa gaactctatg agggagacac tgtcattccc attttgtaga 30 961 tggacaaact gaggcacaga gaagtcatgt gacttgccct agttccgtca gctagtgaat 31 021 gggagagcca gaattccaac acaggcacat ttctggagac agggcatagg ttcctccaga 31 081 tcctcaaagg catgtgggac caggaaagaa gccataggtc tgtgctctga aacatggcaa 31 141 gaacactgtt caaaccatcc catcatctcc ttcctccacg agtcctctag aatcatgtgt 31201 ggctcctgga aaccgcagct tgaaaaggat tggtgagaag cσtaattcct cctagaagta 31 261 gtgtggtagt gtaattcaga cttagattgt tctttatggg tgagagagag ggcaaattac 31321 aatagataaa ctggctgggt gccgtggctc atgcctgtaa tctcagcact ttgggagcct 31381 gaggtgggtg gatcgtttga gcccaggagt ctgagatcag cctgggaaac atggtgaaac 31441 cctgtctcta caaaatacac aaaaattagc ggggcttggt ggtgcacgcc tatagtctca 31 501 gctatctggg aggctgaggt gggaggattg cttgagctca ggaagtggag gttgcagtga 31561 gttgagattg tgctgccgta ctccagcctg ggcaacagag tgaagccctg tctcaaaaat
31621 aaataaataa atcatcggct agtcaacaaa atattaatag aaaaatatgg gattagaagg
31681 gataagaaca cagccatgga gatgactttt gaaattgaag aaactagtgc atgcttataa
31741 attggagtgt cccaacatta aataataatt ttctagtatt tctaaattgc caaaattgac
31801 tcgagtgaaa agcacaaaaa gaccaattac cacagaagaa aatttaaaaa ttatcatctc
31861 taagaaagac accagcccta gggagtttta gcatgagtta tttcaaactg gaagaacagt
31921 gaatttctgt gttatgtaaa ctcttccaga gcatatgggg aaaatgctga attgatttta
31981 tgcttctgaa ttgattttat taagctaatc ctaacaccaa actctgataa agattgctat
32041 cctgcgccac ccaccctcac gctgataacc acagaccaat tttactcctg gctgtgaata
32101 cagaagtcct ggataaaatg ccaccagtgg aatcctgtac cattgtaata ccagatgcag
32161 cccgtgtttg gcatgctttc ccctccacca gatgtgtgct agggcaaaac tggaacctga
32221 tatctgggtc caggcaattt ggacacaaca ttcacttctg tggtcctaag cgccccctct
32281 caggaagcaa agagtaaaat gaagcaggtg tccaaagctt gcaaatatgc agaaaggcta
32341 cagcttggat tactgctgtt gactggcaac atagttaacc acaatatcct gttagagtga
32401 tcattcatca tttctttttt ttgtttgttt tgagactgag tctctttctg tcgccaggct
32461 agagtgcagt ggcgctgtct cgactcagtg caacctccat ctcccgggtt caagcaattc
32521 tcctgcctca gccttctgag tagctgggac tacaggtgcc tgctgccatg cccagctaat
32581 ttttttattt ttagtagaga tggggcttca ccatgttggc caggctggtc tcaaactcct
32641 gacctcaaat gatccactcg cctcggcctc ccaaggtgct gggattacag gtgtgaacca
32701 tcatgcccgg ctgttatttc ttttccttgc tgagaagttc ttaagtattt tttgtgcttt
32761 ttttcctttt tatggtaggt ggctaccttc tctacctttt ccctgcaggg tttgataaca
32821 tgattgaata agcaagtcct aataaatgcc ctctttgctg tatcaacatg catacccccg
32881 aaaacttggg aaacagtgcc tgtcgtgccc tgggaaaccg aatcctgggc ccaagggaca
32941 tgatccagct ggtagtgccc ctgtgccagg tgagaaaaag agaccttgcc ctctgctgga
33001 gttgcagcag cctgggagct tctcagccag ggaacagatc atcgctgcag ctggaggaca
33061 ccctatttca gatatgtgac atcagaggcc atctcatttc tgattcacag ccattgcccc
33121 ttccacttct tcacaaaaat tcaagtatat taagaaatac atattttttt gagacgaggt
33181 ctcactctgt cgcccaggct ggagtgcaga tcatggctca ctgcagcctc gacctccttg
33241 ggctcaggca atcctcccac ctcagcctcc caagtggctg gaactagagg cacgtgtcac
33301 catgcctggc taattttatt tatttatttt ttgtattttt ttgcggagac agggtttcgc
33361 catgttgccc agtctggtct caaacttctg agctcaagta atcctcctgc ctctgcctcc
33421 caaaatgctg ggattacagg catgagccac agtgtctggc aaagaaataa tctgcataca
33481 gcaaaattta ccctttttag gtgaacagtt tgatgagttt tgacaaatat atgcagtgat
33541 ataaataccc ccacagtgaa gatgtaatac ctccatcact caggacttcc ctcttgcctc
33601 tttgtgctcc gttttctacc tcccacctcc agcccccggc aaccactaag ctgttttctg
33661 tttctgtagt tttgtctttt ccagaatctc aaatatgtgg aaccacatag tatgtggcct
33721 tctatatctg gcttgcttca cttaacataa tgctttttta atttaaattt tatttttatt
33781 tatttatttt tgagactgag tctcactttg tggcccaggc tggaatgcag tggcgtgatc
33841 ttggctcact gcaacctccg cctgccaggt tcaagcaatt ctcctgtctc agcctcccaa
33901 gtagctggga ttacaggcac acaccaccat gcctggctaa ttttttatat ttttagtaga
33961 ggcggggttt cgccatgctg gccagtctgg tctccaaatc ctgaccttgt gatctgcctg
34021 ccttggcctc tcaaagtgct aggattaσag gcaggagcca ccgtgccagg cctatttttc
34081 atttttgaga cagtctcacc ctgttgccca ggctgaagtg cagtggtgca atcttagctc
34141 actgcaacct ctgtctcccg ggttcaaacg attctcctac ctcagcctcc tgagtagctg
34201 agattacagg tgcccaccac cacgcctggc taatttctgt atttttagca gagacaggtt
34261 ttctccacgt ttgccaggct ggtctctcaa gtgatccgcc cacctcggcc tccaaagtac
34321 tgggattaga ggcatgggcc tctgcacccg gcctaatctt atttttaatt gtaaactgac
34381 aaataacagt tgtatctatg gagtatgaag tgatgttatg atgtattaat atgatgttga
34441 ataatcaaac tgagctaatt aacatatcca tcacctcaaa tactgttctt attttttgta
34501 gtaagaacat ttggaattta ttctgttgat aattttgaaa tgtacattat ttaagatatt
34561 tgaccagggg tggtggcaca tgcctgtaat ccaaacactt tgggaggcca aggcaggcgg
34621 atcacttgag ctcaggagtt caagaccagc ctgggcaaca tggtgaaaca ctgtctctac
34681 aaaaaacaca acaattagct agggatggtg gtgggcactt gtagtcccag ctgctcagaa
34741 ggcagggatg ggaggatcac ctgagcccag gagtttgagg ctgtagtgaa ttatggtcta
34801 gccactgcac tccaacttgg gtgacagagg gagatcttgt ctgaaaacaa aaaacaaaaa
34861 caaagtggct acatgctcac cagacacatt atatcctctt tttttttttt tttttttttt
34921 tttttttttt tttttttttt tgagacggag tctcactctg ttgccaggct tgagtacagt
34981 ggtgcaatct cggctcagtg caacttctgc cccctgggtt caagcgattc tcctgcctca
35041 gcttcccaag tagctaggac tacagacacg tgccaccaca cctggctagt ttttgtattt
35101 ttagtagaga cagggtttca ccatgttggc caggatggtc tcaatctctt gacctcgtga
35161 tccgcctgcc tcaatctccc aaaatgctgg gattacaggc atgagccact gtgcctggcc
35221 tgtatcctct ttttaaaagc cattctagta ggtatcctgt ggcagtcatc tttccatatt
35281 cctggggact gattccagga ctcctgaaaa taggaaaccc cgggcatgct caagtccctg
35341 atataaaata gtgcagcgtt tgcatataac ccaggcacat aacccgctct actttaattt
35401 atctctagat tacttatgat ccctaatata atttaaatgc tatgtaaatc gttgttatgc 35461 tgtattgttt ttatttgtat tgtttttatt gttgtattgt tatttttttc aatatttttt
35521 atctgtgtgt tcactgtgca gttggttgaa tccgtggatg tggaacccgt agataccgag
35581 ggctgactgt atttcattct ggtttaaatt ttcatttccc tagtgactaa caatgttgag
35641 catgtgttca tgtggttgtt tgccaggata tctcttcttt gatgaaattt ctgttcagat
35701 cctttgccca tttttaattg gcttgtttgt ctcattattg agttggaaga attctttatc
35761 tattctggat acaagttatt catcagtgat atgttttgca aatatttttt cccaatctgt
35821 cgtttgtctt ctcatttttt actagtacct tctaaagagc ggaagttttt aattttgata
35881 agagccaatt tatcggtttt ttttcctttt atgggctgtg ttttttgtcc tatctaaatc
35941 ttaacttaaa caatgtcaca aagattttct gtaagcactg caataaatgg tatcccatga
36001 gtttttagga ctaagttcta atttttgatt ttgcccaaat ttctatctaa gggatctagg
36061 gagtcatgcc ctacaaatcc taaattctca tcagatgggt tttatttata tattgtgact
36121 tacttttcaa tctgactctg gtataacatt acgagacaag gaaaaaatat ttaaccccaa
36181 aatatatttc cctgccatag cttgaaattg ccctgcaagt ctcttgtggg aaaaatccac
36241 attctataga gaatcccctt gcccctttgt tttccttcct tcctttccag atccaggaga
36301 taatcaacta agagccaggc actcttttag gtctaataag aaacatttta caacctgctc
36361 tctctctcct ctctgtctga agtctgctat ctgagagatt cctctgcaca ataaaacttg
36421 gtttccacaa tcctttattt taacctgaac atttcctttc tattgatccc agatcttcag
36481 acaaactcaa ccaattgtca accagaaaat gtttaaattt acctatagcc tggaagtccc
36541 cactttgagt tgtccctcct ttctgaacca aaccaatgta tttcttaaat gtatttgact
36601 gatgtctcat gcttcctaaa atatataaaa ctaagctgca ccccgaccat cttgggcaca
36661 tgttcacatg ttctcaggag cttcggaggg ctgtgtcacg ggccatggtc actcatattt
36721 ggcttagaat aaatctccta aaatatttta cagagttcga ctcttttcat cgacagtgtt
36781 gatatgttgt atttttattt ccattagaat atttctaatt atcctcatgg tttcttcttt
36841 gaaccataag ttatctaaaa gtgtgttgtt tgatttccaa acatttgggg actttccaga
36901 tatctttctg ttactgattt atagtttaat ttcattatgg tgagaaaaca tactttgtat
36961 gatttcaatt atttttaatt tgttaagatt tgctttatgg cccagaatat ggtctatctt
37021 gctaaagttc catgggcact caaaaagaat gtgtattctg ctgttgttgt gcgaaatgtc
37081 ctataaatgt caatcagatt gttggttatt agtgttattc aagttaccca tacccagcct
37141 gattttctgt gtactcgctc taccaaatat tgagagaaga gtggatgtgt ctatttctcc
37201 tttcagctct aacggtctcg attgcatgta ccctgactgt gttctccagt gcacatgcat
37261 ggacagttat gatgtcctct tgatgaatca acccctttat atacagtcct tctttattcc
37321 tggaaatatt ctctgtttct gcttcatctg acattaatat agacacttga gctttctttg
37381 gattagtgtt tgcatggcat gccttttttc cattcctttg gttttaggct atctaggtct
37441 ttattattat tttttatttc ttttgagaca gagtctcgct ctgttgccca ggctgaagtg
37501 caatggcgtg atctcagctc actgcaacct ccacctcccg agttcaagcg attctcgtgc
37561 ctcggcctcc caagtggttg ggattacagg catgtgccac cacatccgac taatttttgt
37621 atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc
37681 aggagatcag cccgcctagg cctcccaaag tgctgggatt acaggtgtga gccaccgccc
37741 cagccctagg tttttatatt taaagtgtgt ttctcacaga cagcctgagg gtcccggaaa
37801 ttttctggaa gttgcggctc caccctcagc tctcagcaac ccctgctcgc ctgcactacc
37861 taggggatgc gtggtcttgc cctcctcctg gtggtaaatg tctctgtgtg ctcttgcccg
37921 ccccctggtg gtaaatgccg ttgctgctac tcttggttgg gctagtagtg gaggcagttt
37981 gtggacgtgt gttaaagggt ttccggacgg tgggatgttg ctccattctc ctggcccagc
38041 ctccgcagag cctgtgtact agggtctcag aaggtggagt cttcgaagtg ctcctgtccc
38101 tcctgtcgtg ccttctatct cctgtgggtt taacacagga gagtgcgtcc tgcgcctccc
38161 acaggggcaa gtggtgttta ctttgatcct gccccagaag cagtggatct tcgtttctgc
38221 ctctcccgca gcagccctgg ggccagagag tgcagcctcc cacgtggttt tgcccagaga
38281 gaatcgtcct ggggaagcag gtgggggtcg ctgcacagca gtcaatcacc gcttgagtgc
38341 ttgtgccacc agcaaggggg aggggtctct cccggctccc cctctgcctc cagtcttttt
38401 cctgcagtga aggcctgtgc aaaaagctca gaaggcaggg cagactccct cctgcccacc
38461 acatgctctg cccaagacag ttggtcttgc ctttccttgg aggggcttgt cactctttgg 38521 aattcagttc tcttggttgc ctgccacctc agctatctga ctggtttaag aaattatggt 38581 tttgcaaatt atctggtgtt ttgttattgt tagagtcggg gggcggggtg gttcattcct 38641 gtactcccag cactttcggg ggtgaggtgg gtggaccctt tgagccctgg agttcaagac 38701 cagccagcct gagcaacatg gggaaaccct gtctctacaa aaaaaaaaaa aaaaaaaaaa 38761 aaaaaattag ccagacatgg cgacaggagc ctgtagtccc agctactcag gaggctgagg 38821 tgggatgatc actggagccc ccccagaaaa gaatgggaat gatgttccct tgtggttttt 38881 ctatatccta agaggaaata aaacactctt ctctttcact tttaacatat gcaaatgagt 38941 gactctaaat gccttctagg gcaatgtctc atggcttaca gtgcctcgtg gtttttctca 39001 tttctttcat gattgcagct gtatttgcta ccacttgtgc agctgacatt taccaagccc 39061 ttactgtgtt ccagcatgct ttcatttaga accatccctg actcctcttt tctctcaaac 39121 ccacgttcaa tttgtcagat aatcctgttg gccccatgtt caaaatataa ccagttcctt 39181 tcaaaaataa aaatggactt atcataaaac ccggcaattg cactgtcatg catttttccc 39241 agagaaatga aaacttattt tcatggtgga acttgtacac aaatgttcat agaagcttta 39301 tttataatag ccctaaacca gaaaatactc acaaactatg gtatattcat accacaggat 39361 actattctgc tgtagaagga atgaactatt ggtacaagca acaacttgga tgaacttttg
39421 ctgagtgaaa aagccagcct caaaaggata catcactgca tgattctatt tacacggcaa
39481 ataatataat tagagaggga atagactagt ggttgtcagg agttaggaat gtgtattagt
39541 ccgttctcct ctttctataa agaaatacct gagactgggt aatttataaa gacaaaaggt
39601 ttaattggct catggttctg cagtctgtac aggaagcgtg gtggcttcag cttctgggga
39661 ggcctcaggg aacttacaac catggggagg gcaaaggagg aggcaggcac cacttacatg
39721 gccagagcag gaggaaaaga gatgggaggt gctacacact tttgaacaac tagatctcat
39781 ggtgctaatc cattcatgag aactccaccc ggtttggtgg ggacccagat cagtaccata
39841 tcagaaggga ggggagggtg tggctgtaaa ggggttacac gagaggcttt gtggtgatgg
39901 tacagttgag cacctcggtc attctggtgg ctactccagg ctacacatag ggcaaattta
39g6l catagagcta ctttgtggtt ggctgggtgc gacggctcac atctgtaatt ccagcacttt
40021 gggaggctga ggtgggggga tgacgaggtc aggaggtcga gaccaacctg gccaacacgg
40081 tgaaaccccg tctctactaa aaatacaaaa attagccggg tgtggcagtg tgtgcctgta
40141 atcccagcta ctcaggaggc tgaggcagaa gaattgcttt aacccgggag gaggaggttg
40201 cagtgagcca agattgtgcc actgcacttc agcctgaaaa cagagtgaga ctctgtctca
40261 aaaaaaaaaa aaaaaaaaag cttttttgtg gtctttgtgc tgataccaaa taagtggtat
40321 catttccaac accaatcgat tttctgcttc tgtgatacca attgggtgtt caataattca
40381 attctattct gatactaacc tggagttagt gtcagactcc acaggctgaa gggctcagtc
40441 ccataagact acccccattt ctcccaggcg cagtggctca cacctgtaat cccagcactt
40501 tgggaggctg aggcgggcgg atcacctgag gtcaggagtt cgagaccagc ctggccaaca
40561 tggtgaaacc ctgtctctac taaaaataca aaaattagcc aggcctggtg gcgggcacct
40621 gtaatcccag ctactcggga ggctgaggca gaagaattgc ttgaacccag gaggtggagg
40681 ttgcagtgag ctgaggtcac gccattgcac tccagcctgg gcaacaagag tgaaactcca
40741 tctcaaaaaa aaaaaaaatg gctgggtgtg gtggctcatg cctgtaatcc cagaactttg
40801 ggaagccgag gcaggcggat cacctgaggt caggagttcg agtccagcct ggccaacatg
40861 gtgaaacctc atctctacta aaagtacaaa aattagccag gagtggtggc gagtgcctgt
40921 aatcccagct acttgggggg ctgagacagg ataattgctt gaacccagag gcggaggttg
40981 tgtgagccga gatcgtgcca ctgcactcca gcctgggtga cagagtgaga ctcgatgtct
41041 ccaaaaaaac aaaacaaaac aaaacaaaac tacccccatt tcacatgcca gtcacaagta
41101 ctgggtcccc aggttaccca cacttctgtc cagccaacta caaatttgga ggttcccgtg
41161 acctccattc ctcaggtttg ataatttgct agaatggctc acagaactca aaaaaacaca
41221 ttacttcacc attactggtc tattgtaaaa gatacaactc aggaacagcc aagtgaagag
41281 atgcatagga ctgggtattg tagggtgggt gtgcagagcc tccctgcctg ctctgggcgt
41341 cacccctcca gcatctccat gtgttccaac ccagaagctc tccaaactcc attgttttgg
41401 aactttatga aggttccatt acagaggcat gattgatgaa atcattggtc attggtgact
41461 gaactccatc cctagccact gtccactccc tggaggtcag agagtgaggc tgaaagttcc
41521 aactctctca tcatcaatca tggcttagtc tttctgatca gcagcctgta tccagaaact
41581 atttagggtc ctcattaaca taagctcagg tatggttgaa aggggtttgt tatgaataac
41641 aaaacatcac tgtaactcag gaaattttag gagggtttta aaagatctgt gccaagaacc
41701 agggacaaag gccaactcta tttttctcac tatatacatg atttcccatt tcctacaggc
41761 acacacaaac acacacacaa atgggtgcgt gcataactgg ttagatctga ataaactcaa
41821 tggattgtgc cgatgttcca tttcttcgtt ttgatactgt actctggtta tgtgagttgt
41881 tcgcatgaga ggtagggaac atgggacttc tctctacatt cctttgtgac cttctgtgac
41941 cctacaatta tttcaaaatt aacaacttag aatacaaata accagagtcc acctcccgcc
42001 ctgctaccag cctggtccac accactctct tttcttgcct ggattattgc aacagccgct
42061 tttttttttt tttttttttt tttttttttt ttttttttga gatggagtct tggaacagtt
42121 tcttaatggg tctgctttta catacaatct attctcaata aagcagcttc gtaagacaga
42181 tcctaccatt tgtagaaata aacaaaaacc attcagagct tgctgtagca aggttgtcag
42241 ccagcatcac ttgcattttt gtagggactc aaaatcaggc tgagccttat tgtcggtggg
42301 ccgggggtag gggtgcggga aaggaggtgg gggaaggctt ggggtgtgcc ctgattggag
42361 gctattggcc tggagaagct gggtgggata atttggaggg gattctgaga ttggctgggg
42421 aggggtgggt gcatatttgg ctttctcttg ctggccctaa gttggaagct gggacaaaaa
42481 ttagggaagc tgccagtttt taatcaagtc ctggcctttc ggggctgatt gttagagaag
42541 ttattgtttt gcttcctgga tggctactgg agatagtgat ctggcttcct tcatgtctga
42601 cttatagcag actggcatcc tgggctgtgg attccagatg agggggttgg tttcctgggc
42661 agcttgctgc aggttaggct cagagttcta gtttccacag ggtctggcca tggtgcacgt
42721 gtatgttcag tccctcatgt tcctctgctt agaaccctgc aggggctccc actgaacaca
42781 gcccttcctg tggcctacca ggccctacat gagctggccc catttcccct ctggcctggt
42841 cttctgccac tctcctccct ctctccatcc cagccacaat ggcctccttg ctgttctaga
42901 acatgccagg ccctctccca aggcattcat ggccttctaa catactgtat gcctttctta
42961 tttttctctc tctctctgtt tctcactctc tctctctcta tatatatata tgtatatacg
43021 tacgtatata cctatatgta tatacatata cacacacaca cacacacaca tatatatatg
43081 tgtgtgagac agagactcac tctgttgccc aggcttggag tgcagtggtg tggtcctagc
43141 tcactgcagc ctcaaactcc cgggctcaag ctatcctccc acctcagcct cccaaagagc
43201 tgggattaca agcaggagtc aatgcacccg gcctcctttc tgatttttaa tgcttattgc 43261 ttatgtctag ctctcacaac tagaatgtaa attccacaag gacagggttc ttggtgggtt
43321 tgttccctac tatatccttg gcacctagaa cattgccttg cccagcacat agtgagtgcc
43381 caataaaaaa tgtttgagtg aatcaatgag tttgtgcgta catgtgtgca gatacattta
43441 ctaacatcta ctacttctaa ttaggtgctc agtgtttact agacactatg ctaagtgctt
43501 tcatctagta tctaattttt attcttcata gctttcctat gggtaggtga catcaggcca
43561 cttatctttc aggtaaagtg gtctcagagg acatgctgaa agcccatgag cttctcaggg
43621 acctaaataa atgtttaaaa cctgagaaaa gtcttggctc caaaatgtaa aaactacaga
43681 atcatccaaa ttaataaatg tttaatcaaa tgtctacaaa gtgtcatcga ttgttaattt
43741 atgtcattaa ttctctattg gcctctttaa ttattaaatg cagtgttcat aagaatttca
43801 ttacttttga aaagaatttg tagactagat gttaactctt ggagcacagt catgtatctg
43861 ttaaccacag gaataccatc agaaaaatgt gtcattaggt gatttcaatg ttgtacaaac
43921 atcagagagt gtccttacaσ actctgtgat gtgtagcctg ctacacactt aggctataag
43981 agatagacta ttgctcctag gctacaaacc tgtacagcac gtgactgtac cgaatactgt
44041 aggcaattat aatacaataa taagtatttg tgtatctaaa catagctaaa catagaaaag
44101 gcacagtaaa aatatcatat aaaatattta aaatgtacac ctgtttaggg tacttaccat
44161 gaatggagct tgcaggactg gaagttgctc tgggtgagtc cgtgagtgag tggtgaatga
44221 atgtggaggc ctaggacaat actgtacact actgtagact ttaaagacac tgtcacctag
44281 gctactacac taagtttatt aaaaatatta ttctttggca gggcgcggtg gctcacgcct
44341 gtaatccctg cactttggga ggccgaggtg ggtgaatcac ctgaggtcag gggctcgaga
44401 cctgcctggt caacatggtg aaaccccatc tctactaaaa atacaaaaaa ttagccaggc
44461 atggtggtgg gcacctgtaa tcccagctac cagggagact gaggcaagag aatcacttga
44521 acctgagagg cggaggttgt agtgagccga gattgtgcca ttgcactcca gtctaggcaa
44581 caagagcaaa actctgtctc aaaaaaaaag tttttcttca gtaataaatt agccttagct
44641 ttctacaact ttatgaactt taaaattttt tttaaacttt ttgacttttt ataataacac
44701 ttagcttaaa acacaaacac attatgcagc tatacaaaaa tattttcttt ttttgtatcc
44761 ttattctata aactttttat ttttcaatta ttttattttt acttttaaaa cctttttgtt
44821 aaaaactaag acacaaatac acacattagc ctaaacctac atagggtcag gaccatcaat
44881 atcactgtct tgcacctcta caccttgtcc cactggaagt tcttcatagg caacaacacg
44941 catggagctg tcacctgcta ttgcaacaat gctttttttc tttttttttt tttgagacag
45001 agtcttactc tgtcgcccag gctggagtgc agtggcacga tctcagctca ctgcagcctc
45061 cacctccaag gttcaaggga tcctcaagcc tcagcctccc aagtagccgg gagtacaggc
45121 acgcgctacc atgcccagcg acggggtttc gccgtattgg ccaagctggt ctcgaactcc
45181 tgacctcagg tgatccacct gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc
45241 accacgccca gcggacaatg ctttcttctg caatctctcc taaaggacct gcctgaggca
45301 cttcttgaag aagtgtccgt cttttcagaa gtatgtccat ggtggtttgc caagtttgtt
45361 tctttcttcc gtcatagatt tgcatgagta atgctttgtg tcagctaaaa tgttacatcg
45421 gctatgacgt cactaggtga taggaatttg tcagctccat tataatccta tgggaccgcc
45481 atcggatacg cagcccatca ctgacctgag acgtcgttat ttagggtgtg actgtacttt
45541 aagaatgcaa atgaataccc agggagggct gagaacgcgt aggtaattac accataaatg
45601 aattactctt agccaagtaa tttccaaggc aaacatacaa aaatcacctc gtgttacctg
45661 acagtgctat gttatattta acgtaagaaa tctgtgtatt ttaatattta ataaggtgtg
45721 ggaaggaact tccaaaggta atagcatctg gtcctagcaa ggtcttaaaa cgccgtttga
45781 tttcagaatg cctcattttg tagatttaat ccagaatctg cagtttctgg cgacgcagta
45841 gtccgtctcc cccagtttct cctggccaaa gcctcccacc ttcctctcta cccccacaac
45901 cctgtcaagc gcacctggac caggtacaac aggggtgtgt gtgtgagtgt gagtgtgtgt
45961 gtgaatgcat ttgggaaagg ctaggcaggg tgaatattcc ctagaccccg ctcttcaccg
46021 tcactctact acagcagctc actgccctgc cccgcccctc cccggccctg gaaagcagcc
46081 tctggaaaga ggaaaccagσ tatctcccgt gttgccacaa gatggcacca caagctcggg
46141 actggctttc tttgcgttcc cgtcagaaaa aaacgagagc tctgacctag gagccgaggc
46201 tcccagggag acctctggac gccactcccc gggctgcttc tcctcctcgg ggtgactcgg
46261 gccctctgga gtgacctgca tagctttgtg gttcgggctc ccatggggcc cagaagccag
46321 catggagact tagggcttct cttgggccac ttttctcctc atacccagca tgcagaccaa
46381 ggttggggat gaattctgaa cgtggggcag agtccctgtc cccagagcaa ctctgagagc
46441 accttgccct tcttcccagg gcacaggcac cagccttcct ccccagctca gtccctgctt
46501 ctttctaaga caggttcttg ctctgtcgcc caggctggag tgcagtggtg caattatggc
46561 tcactgcagc ctcgacctcc tcctggtgag aggtgacagc gcgcctgcag ccctcgctct
46621 cggcgcctcc tcggccttgg tgcccactct ggccgcgctt gaggagccct tcagcccact
46681 gctgcactgt gggagcccct ttctgggctg gccaaggctg gagccggctc ccttagcttg
46741 cggggaggtg tggagggaga gccgcgggcg ggaaccgggg ctgcgcgcgg cacttgctgg
46801 ccagcgcgag ttccgggtgg gcgtgggctc cgcgggcccc gcactcggtg cggccggccg
46861 gccggcccgc aagccccggg cagtgagggt cttagcacct gggccagcag ctgctgtgct
46g21 cgatttctcg ccaggcctta gctgccttcc cgcggggcag ggctcaagac ctgcagcccg
46981 ccatgcctga gcctcccccc agctccgtgg gctcctgtgc ggcccaagcc tccgcgatga
47041 gcgccgcccc ctgctccatg gagcccaatc ccatcgacca cccaagaact gaggagtgca
47101 ggcacacggc gcgggactgg caggcagttc cacctgcagc ccccgtgtgg gatccactgg 47161 gtgaagccag ctgggctcct gagtctgttg gggacttgga gaacctttat gtctagctaa
47221 gggattgtaa atacaccaat cggcagtctg tatctagctc aaggtttgta aacacaccaa
47281 tcagcaccct gtgtctagct cagggtttgt gaatgcacca attgacactc tgtatctacc
47341 tactctgctg gggacttgga gaacttttgt gtctacactc tgtatctaac taatctagtg
47401 gggacatgga gaactttcgt gcctagctca gggattgtaa acgcaccaat cagcaccctg
47461 tcaaaatgga ccaatcagct ctctgtaaaa tgggccaatc ggctctctgt aaaatggacc
47521 aatcagcagg atgtgggtgg ggccagataa gagaataaaa gcaggcttgc ccaagctggc
47581 agtgacaact cgctgaggcc cagtttacgt tggcgaagct ttgttctttc actctttgcg
47641 ataaatcttg ttgttgttca ccgtttgggt ccgcgctgcc tttatgagcc gtaacactca
47701 accgcgaaag tctgtagctt cactcctgaa gctagcgaga ccacgaaccc accgggaaga
47761 agaaaaaact ccagacgcac cgccttcaga gctgtaacac tcactgggaa ggtctgtggt
47821 ttcagtcctg agcccgtgag accacagacc gaccagtggg aagaaattcc gcacacatct
47881 gaacatcaaa agtaacagac tctggatagg ccgcgtttaa aaactataac acttaccacg
47g4l agcatccgtg gcttcattct tgaagttagt gagaccgaga acccattaat tcccgaaaca
48001 cactgggcgc aaatcttccc ttctcagttt tccaagtagc tgggactaca ggcgccaacc
48061 accatgcctg gctaattttt tttgtatttt tagtagagat ggggtttcac tgtgttaacc
48121 aagatggtct caatctgacc tcgtgattca cccgcctcgg attcccaaag tgctgggctt
48181 acaggtgtga gcccgcacac ctggccacca gttatttttc aattgttctg tttccctgtt
48241 cttgccttac taagaaagta attttgaaat gaccgatccg ttctttgttt tttgtttctg
48301 gtttcttcag cttattctgt ctgtaaaacc tgcgtcctct gctccgctcc atgaagacgc
48361 tcattctgtt ttatagaagt tagtaagtgt gatatatcta ttctttgttt ttgtctatag
48421 ttcctggctg acagcccata taatcattgt aatttcctag gagactagag tgtgataaga
48481 gtatctttcc ttaaaatatt tggcctttca tcctttgttc ttgaaacagc tctggagcag
48541 ctccagagta agcataaagg tgaaagatgg gccSggcgga gtggctcacg tttgtaatcc
48601 cggcactttg ggaggccaag gtggcagata acgaggtcag gagttcgaga ccagcctgac
48661 caacatggtg aaaccctgtc tctactaaaa atacaaaaat taggtgggcR tggtggtgca
48721 tacctgtaat cccagctgct caggaggctg aggaggagaa ttgcatgaac tcgggaggca
48781 gaggttgcag tgagctgaga tcgccactgc actccagcct gggcaacaga gcgaaactcc
48841 atctcaaaaa aaaaaaaaaa aaagtgaaag tcgggcttgN tgtttggagc cacaactgag
48gθl cttaacgttt ataaccacag gatggatggc tgcttgccag gggatccaac cgtctgctca
48961 gagccccacc ctccacattc ggggaggaga gaggaaccga aggttgatca ccaatggcca
49021 gtgatgtaat tgatcatgcc tacataatga aatcgccata aaaacccgta acgactgagt
49081 tcaggggttt cccaggaagg tggtcttgta tggaagattt tgtattcggg gatggaagct
49141 tttgtatttg aggcccttcc agagtgtgcc ccgtttatgt cttcatctgg cttttcattt
49201 gtatccttta aaatatgctt tatgataaac tgctaaacgt aagcaaatgc ttccctgcat
49261 tctgtgaggt gctctagcaa attaatcaaa cccaagaaga gggtcatgag aatcctgatt
49321 tatagccagt tggccagaag tacaggtaat acaacctggg gcttgtaatt ggcactggaa
49381 gtgggggacg gtcttgtggg actgggatct gacgctatct ccaggtagat agtgttggaa
49441 ttgaattaag aacacccagc tggtggccac tgcagaactg gctccttgct tgatatgggg
49501 gggtggggga accccacaca tgtggtatca gaagtgtgtt tctggagtat agtaggagaa
49561 attgagtttg ttttctgctc atacacagag aaacaaaatc actaaagagc aacaaattgt
49621 attctgttca gataatatag tggaagaaat attccactta tagtagtacc aaaaaggata
49681 aagtacttaa gaataaatgt tcagacgata taaaggacat ttcaaaactt ctaaaggaca
49741 caaaagacat caaaacacac catgttcaag gataggaaga ctcaatatca taaagattgt
49801 cattttcttt tttttttttt tgagatggag tctcgctctg ttgctgggct gggtggagtg
49861 cagtgactca atctcggctc actgcaacct ccaactcccg gatgcaagcg attctcctgc
49921 ctcagcctct caagtagctg ggactacagg tgcatgccac cacgcccagc taattttcgt
49981 atttttagta aagacggagt tttacccatg ttggccagaa tggtctcaat ctcttaacct
50041 cgtgatccac ctgcctcagc ctcccaaagt gctgggatta caggcctggg ccaccatgct
50101 tggccaaaga ttacaatttt ctatgagtta cttgacacat ttaatataat cccaataaag
50161 atacaatatt ctttttaaaa aactacacca ggtYattcta aagttcattg aaaaaacaaa
50221 cactagtcag ataaagacac tgacagtatt ctttttaaaa aactacacca ggtaattcta
50281 aagttcattg aaaaaacaaa cactagtcag ccatggtaag tggcttgcat ctgtagtccc
50341 agctacttgg gaggccaagg taggaggatc acttgaaccc aggaatttga ggctgcagta
50401 agctatgatc acacctgtga atagccacta cactccagcc tgggcaacat agcaagactc
50461 tgtctcttaa aacaaaaaaa ggcagaaggt ctttcttaag aagcattaaa aagaattcct
50521 cctatagata tttaacattt tatggcaccc caataattaa agtggtccta gagaatggat
50581 aaacattagc ccaatggaac agagcagaaa gccccactat agacctcaac acaaaaaatt
50641 catggtgttg aaaaaagggg gatcaatatt ttatacttta tacttattta aattccaaat
50701 gagtttacaa ttttacaagt aaaaaataaa agagaataca ttaaattctg ttatgatctc
50761 agaatggagg ttttttttac ttatgactca aaatccagaa gtcataaaat atttatcaat
50821 tcaaatacat ttttaaaatt tcatgagaaa acattataag caaagacaaa atgcaaacca
50881 acaaattggg tgaaaaattt acagctcata tcaaaaatgg ctaatcttcc taatatttaa
50941 agagctccca aatgtcaaaa acagaaatag aaacaaccag cactagaaaa atgaacaaag
51001 tagataaaat aacagtttgt agaaaaggag acacatggct cttaaacata ttagaagatg 51061 ctcaacctca ctcaaaataa cacaaaagca aatgaaaagg tttctaggta attcaatggg
51121 gaaaagatac ctttaaacaa aaagtgctgg aacgattgga tatcaccatg aaaaaaaaga
51181 acgtcaactt ttacttcaca ccatatacaa aaattaattc gaaaatggat cacaggtcag
51241 gcaaggtgtc tcatgcctat aattccagca ctttgagagg ccaaggcagg tatataactt
51301 gagctcaggt gtttgagacc agcctgggca atgtggcaaa accctgtt c tacaaaaaat
51361 ataaaaatta gccaggtttg gtaatgtata cctataatgc caactacttg ggaggctgag
51421 tggggaggat tgcttgagcc caggaggttg aggctgcagt gagccaggat tgtgcctctg
51481 cactcagcct aggcaacgta tggagagtct ctctctctct tttttctttc tttcttcttc
51541 ttttaagaga tcaggtcttg ctgtgttgtc caggctggcc tcgaacttct gggctcaact
51601 gatcctccct tagcctccca agtacctggg aatataggca tgtgtcactg catccagcta
51661 tactaagaac ttttaaagct caacaatatt aatagcccat ttcttaaata agcaaaatat
51721 tgaacagata gttcacaaaa gaagacacgt gcccaataag caaattaaaa gtggctcaac
51781 attgtcagtc acacctgtta gagtggctaa agtttaaaag actgactata ccgcatgttg
51841 acaggaccac tttggaaatg tttgacagtt tttcaatcca gcaattctag gtatttaccc
51901 agatgaaaat atatgtccaa acaaagactt gtacacagat gtctggagga gctttattta
51961 ataaccaaac ctgaaaacta ctcaaatgtt catcaatgga tgaatgaata cattgtgcct
52021 ctatctagac aatggaatgt gttggcaata caacaaacta cagatacaca gaataacatg
52081 tattactctc aaaaccatta cagtgagggg gaaaaagcta gacacagaag agtactgtgc
52141 actcatttca ttcatatgaa atgctagaaa agtgaaatgt gatcagcggt tatggaaagg
52201 tcagtggctg ctcaaagctg gaggtggcaa gcactgacgg gaagtgacgt ggagaacttt
52261 gtgagtggat gggaatgttt tgtatttgat tgtagggggt ggtggttact caggtgttca
52321 catttgtcaa agcacctcag atgacacttt ttattttatc tttatttatt taattttgag
52381 atggagtctc actctgttgc ccaggctaaa gtgcagtggc atgatctcaa ctcactgcaa
52441 cttccacctc ctgggttcaa gcaattctcc tgtctcagcc tcccgagtag ctgggactac
52501 agccgtgtac caccatgcct ggctaaattt tgtattttta gtagagatgg ggtttcacca
52561 tatcggtcag gctggtctca aactcctgac ctcaggtgat ccacctgcct cggcctccca
52621 aagtgctggg attagaggcg caagccagcc aaataataca ttttaaaagg gtgtttgttg
52681 tatgtaaatt acacctttaa aaaatatgta aatgctaggg gaagagaaac caaaccaaac
52741 caaaccctgt tctttgctgg agctagaaat ccaagactta caaagcaata aacaattgga
52801 caataaacag gctgggctag atggctcatg cctgtaatcc tagcagttag cgggccaggg
52861 ccaggtggga ggatcacttg aggccaggag ttagagacca gcttgagaag gccctgtctc
52921 tacaaaaaaa aaaaaaaaaa aaaagccagg catggtgatc ctttaagcct gggaggttga
52981 ggctgcagtg agccacaatc actgcactgc actccagcct gggagacaga gtgagaccct
53041 gtctcaaaac aaacaaacaa aaaacaaaaa aataacttga acaataaaσa aaaaaattac
53101 actgagatac aaattttcac tttccagaat gtcaaaagac ccaaaagttt aataacacag
53161 tgtattgaca tgactatgag aaaaaaacac cactgacaat gggagtgtaa attggtataa
53221 tccccagaga aggtattctg gcaatattta ctaaattata aatgctttga tttagcaatt
53281 ccacttctag gattttatct tatagataaa ctctaccaca aatagcacat gttaaaggtt
53341 attcat tgca aaagtattta aaatagcaaa acacaagaaa taatcaaaat gtctatcggt
53401 ccacgacagg ttgaataatt tatgatacat ccatactgtg gaatcctatg taagtacaag
53461 aaagcacagg gaaaggctgt ctgtggtaac atggaaagat cctcagtggg taatgttaag
53521 tgaaaaaggc aacattgtgt ttctatgttg ccatttgtat aaaaacagga acaacaaaaa
53581 cccagaagat acatatttgg attttcttgc atatattttt ttttaaaaaa caaaaccttc
53641 aggaagaatt accaagaaac taatcgcagg ggatggggga aggcatggga aatatgtgtg
53701 gagggagaat tttcataata tgctttccta tctttttaaa tgtttagcca accaaaattt
53761 aaatat tggc tgggtacagt ggctcacacc tgtaatccca gcactttggg aggctgtggt
53821 gggaggatcc tgcgagccca ggagttcaag accagcctga gcaacatggg gagacatcct
53881 tatctctaca aaagagattt taaaaattag ccggttgtgg tggcacaacc tgtggtccca
53941 gctactcagg aagctgaggc aagaggatcg tttgagcccc agagttcaag gctacagtga
54001 gctatgatca tgccactgca ctccagcctg ggtgatagag caagacggtc taaaaaattt
54061 tttttaaatg cttaaaaata aggccaggtg cggtggctca cacctataat cccagcactt
54121 tgggaggcct aggcaggcag atcacttgag gtcaggagtt cgagaccagc ctggtcaaca
54181 tggtgaaatc ccatctctac taaaaataca aaaattaacc aggtgtggtg gtatgcgcct
54241 ataatcctgg ctactcaggt gtctgaggca ggagaatcac ttgaatccgg gaggtagagg
54301 ttgcagtgag ctgagattgt actgtactct aacatgggca acagagtaag actcttgttt
54361 caaaaaaaaa taaaatactt ttcaataaca tcaaaataac acattatata ttaatatatt
54421 aactaggata cttaaactat tatcattatt caccaggtta tcttgaagaa aaatataata
54481 agaagtgtct agtccggtat aaggacatat ttggcacaca gtaatggtta ctatttctat
54541 accctgcccc tcaaatgccc gcacacaacc tgtctggtac ttcaggttct agttccccga
54601 agcccagttg cctgactgcc tcttccagct gtgcccttgc agggacttct cctctgctga
54661 atgatt ttcc ccatctcttc ttattgtcca cctacttggt agctgggatg tggaggacat
54721 cacctcctca ggaaagcctt ctctgattga cacacaccct cctcctccct cttcacaccg
54781 accctt tagg tggcccttgt ccttcctccc ctgtggactg cagggtctgc tcagtcctct
54841 gtagtcctgg agtgctggσc aaggatcgag ctcccctcca cagggtgggg attcatggca
54901 ggggcaggcc ttactctcca cctacacaga catccagaaa agtttcggtt tcccctaaac 54961 gttatgttga tcttcccatg ctcacaaaga agagtttggg tttcccctaa gttgtgatct
55021 catttttcct gtcttcccta ccctccagcc ctaccccagc caaggggccg tgccagcttt
55081 catggtgaag atgcctgggg tttcctgggc agcccttcat atactgtgta atagcaatgg
55141 aaggaatcca caggtgaatg ctgatgcagg aagctcccag tccagcaggg agggcagcca
55201 tatatgcaag gagcagaaac acacaatgtg gaatgggtgc agagagccag gcaagggcac
55261 agaggacaag tctcactggg cctcaaaggg tggccacagt gtggctgcgg ggattggagg
55321 gcaggctttg gaacagacag cctcagctag aaagccctgg gagggcccat gagaggcctc
55381 caagtaggca aaggggcaac agcaggtgca gcagcctggg actctaggaa ggggccctgg
55441 aaacctgaac ctcaatggcc atggcagtga cagaggggtc tgtgctgggc tttagggagg
55501 tgcctcaggc aatgtggagg acctccagga ggcgggacaa ggcagtgtct ggcaaaggca
55561 gggacagaca gcaaacaaga cagagccagg cacccaggaa gggcagagac cccttggggg
55621 agagggaagt tgcggtgcca caggacaggc tgggggctgt tcttaagggg aggctttgat
55681 ttttgtggtt ttgtttttcc cagaagtctc tccaaggagt aagattcctt tcttaggact
55741 caagaagtca gaggccccct tctctggggc ccctggggtt tgggcgagag tactggagca
55801 gaaagcaggg ctgggctggg cctggggcca gacctcaatg actgtttcct tcccgtcagc
55861 gagcggagaa gcagtgacag agtgtaccag gaggggaagc tgacggtggc cccaactcct
55921 ctcttgaatg ggatatgacc accccacctg cccctcagtg tttgcaggac actctggcac
55981 actcatgcct tcctttcctg gtgaacctgt atcccactac aaagaggaac agaactcccc
56041 acccagcccc acccttgctt ccaggggctt tgagacactc aggagaagga gcttcaaata
56101 ttgtgagggt ctgtctgtgt cagccaccag gatgtcaatc cctgcctggg ctggcagcat
56161 ggaccttgtg gaccctccta gcccacccca tgcccccagg agccccgctt ggcttcttct
56221 cttttataca ttgtaaacac cacatttatt tgtctgaggc ttgcaaacct ctggtaagaa
56281 gcacagaacg cagggctctc cttcatgctg ccctgggccc cagctcgcca ggcatgcagg
56341 acRgagctgg cagatgagtc agaaatcttt gggagcagcg ccagggaagc agcaggccct
56401 gctccttccc atgcccaatc ccgccagcac gggcctggac tgcagccagg aaggYgggcc
56461 agccaggatc cccaggtaac ttcgccacag ggacctcttc ttggagctgc cttcccttcc
56521 ctccccatcc ctctccaatc cccgcagagc ttagagcctg ggccacatgc ttggtccctc
56581 acacaaggac caaaccagct gctgtcaggc tgtttctgtg ggtcctgtct ctccagtcag
56641 gaagccagca gggcagggca ggcctggctc tcctcctgga atcacaccgt gcacccagct
56701 cagcgctggg cactcagctg gggaccggRa tggacaaagc cttgtccaga gaaccactRt
56761 aggggagacg tgcatggcag ccggactcag cctcctgcag cctccattca tgggctcttg
56821 gctgggcctg aaatttgtta gggcctcaac tctctgtggt gcagatgaac acctcctcct
56881 ccaagaggcc cctcRggctt ggtgccaggc ttgggactgg gctctggaaa gtcagccaag
56941 gctgctactt caaggccctg aggacagcct ccagcttcat ggccatagcc aggtcgccct
57001 tcaccttcag ccgtccactc atgtaggccc ccaggSgccg cagctctctg catagcaggg
57061 cccgcaggtc tgcctcggcc atctccacca ccacatcagg gatgccatca ggcaccccgt
57121 gtcccactct tcctcgtcct gtggggcaaa agaaaaccga gtgtcagtag gggaatggag
57181 gaacgtgaag gagatctatg ggggtgggag gggctggtat ttcccattgg gaggagagta
57241 ctggttaaga gtttgggttc taataccctg ggtttgagtc ttattggctg tgtgaactct
57301 tggatcctca gtttccaaat ctgtgatgat aattccttta gagatgacaa ttcctaaagc
57361 ataggctcat ggtgagaagt gggtgagata atgtacaaaa agtacttggc acagagcctg
57421 acaggcagca ggcctgtaac acgggcaggc ctcttggtat tggaagcctg gctgcattgt
57481 cctgcggatg gcggggagac cagggcatag ttaatgcctg gaaatggtgt ctgagcccct
57541 gcctgccatg ggttcacccc aaattattgg caggagcagg gggcagtcta cgagagcacc
57601 actggggtag gtaacaagaa acctagcaag ctggatggga aggagaggca aggagggcag
57661 cggcacctgt agtgaggtcc aggaagtagg cgctttgggt gScgctgggc aggacgacat
57721 tgaactggta gcaggccccg acttggctga ccagggcctc agacaggaag ggctgtagag
57781 cagtcagtag cccctccgcc agaggctgct tcggactgga cctggcacca acttgagggg
57841 caggtggctc aacttcactc accatctcca cggtgtctgc tgggggtggc caacagggtt
57901 ggggaaggag gcagagagga ggtcatcgtg ttgccaaggt caggaccact cactgtggcc
57961 tctgcacctt ttgtggcagt ttcctcttag atccccttca ggcctctgtt caacttcctc
58021 ctctaccaga aaggtgcccc tgagttttca gcctaaactg caaactcagt ttctaaacta
58081 ctccagcctc agatataaaa ttctttccag ctgcccttct ggtgatgtcg cctcctccca
58141 tggaggctgc caatggcctc tacacactca gacacctggc ctcctctcac tgccttggct
58201 gtggtcagtg tgggctgaac atctgtgcag ggtgtgtact gcacagagct gctgggatag
58261 tgagcaaagt ctgtgctggc accaagctgg taaacacccc cgctctcctc cccagggctc
58321 ctcacctggc cccggggacg gggcacctcc tgccattgag ttcatgcttc ctcccaggaa
58381 gtgcagggcc agctgctgga gggtgctgtc caggttgggc ccagctgggc tgtcctgggg
58441 cggctggagc acggcctcca ctgccagctc cacgcggtct acctccagcc cccaggccct
58501 ggtcacatcg ttgatctcca gctggaggac agtgtgagga gaaatgtaat taattcaaca
58561 aacctttcct gagcaccttc tttgggcaga ctgtgtggcc gtgcatggac atggaggcac
58621 cacaccgccc ttgagacact cctagcctgg gaacacaggc agagggcaat gacctttcag
58681 ctgtggtaag tgccaagaca gaagcaaggc ctgtggtgag cccccagcag aggagggtgg
58741 tgccagcagg agggagtcct caggtggagg aggacccttc cagcaacagg aacagcatgt
58801 gcaaaacccc agacaagaaa acctggcatg ttcgtggagc tgcgaggaac cagagttcca 58861 tttagctgga ccctcacatg tcggctgagg actggagaca gctgaggggt cagaggtggg
58921 gtgtttctgc ttactttgat ttattctgag gcaacaaaga gccccaggga ggagtttgag
58981 cagggaggtg atacagcaga cttgctttaa ggcaagatcc tcctggctgc tgtggatgct
59041 ggattatagg gggctgaggg gagggatgga gaccaaggaa gacattgttt caaaatacag
59101 ccaaggaatg atgcagctct ggcgagggtg gaggggagct gtgaagccaa gatccactga
59161 gggaggcatg cctctatcaa ctgtactgag ccacaacagg gcactagaga agtgcaagca
59221 ccaggctcgg ggctgcctcg atgtgtgcaa tgatatgaga gggggcggga gtggggagga
59281 gtcaggctcc tgaatggatg agtgtggcat tcactagaga ggacacacgg gggtgggaag
59341 ggagggatgg caactttttt tttttttttt actactgtaa gcttgaggtg tctgtggggc
59401 agtcaattgt ccagtaggca gctggagaaa tggcccaggg tacagaagca tcagggctag
59461 ggcaggacat tgtgaataat cagcatccac aggcagcaga cagcccagat ggatgagctc
59521 tcccagggag gtcacagatg agaagaggcc agtgatgaaa ccctggaaac tcaagggcag
59581 gagaataagt ggcagtaacc agggatgaca gggaaggagg aagtacaggg ggttctgggg
59641 gctgggggct gggtcgacca tgtcaaatgc tgccaccagg tgatgtaagg gaagggctga
59701 gaggtgccca ctgggctggc atgtgggagg tcactgtgat gttggccagc gctgtcttgg
59761 gagcccaagg aggccaggat gaaggatgta ggggcagggg ctgggagcat ggatgaaagt
5g821 cttgcagaag aaaaggggag aaagggagtg ggagctagag ggcactgtgg caaagggagg
59881 gcacatttct acacagaaag gagaggtgac agagagagag tgcatggagt ggagggaagg
59941 catcctggga tagcaggggg cccacagcac tgcgcagtac agggatgagc ctcagagagg
60001 ggaggcagaa gggcaaggag gcaggaaagc agcacagagg caggtgggtt tgaaggggtg
60061 aaactggagg aagcagagtg ctcatcctag agtttttctc ctgagtgtta ggaggcaagg
60121 cctgctgcag agagcaatga gcagtggtgg ggctggagga gggcagtgaa gggctgaggc
60181 agctggcctg gagcactggc aggtaaggag tggtaactgg ctaaggaagg tccagcaagt
60241 gagaggtggg gactctgatt tctctagaag aaaatcaggc aaaaaggggc atgtgaataa
60301 gtgtacgcct gaaccagggc ctgagggcgg tgtgctggac ctcctgaggt tctgtctcaa
60361 ccacaggcac agctctcact ctaccaggtg ctcactcagt ctgggaaatg ggacttaaag
60421 gactctcaca tcctggtgtg gaactgacct ccccaaactg cctgtctcac atcaaaacaa
60481 tgtgcaacaa gactgagatc agttttctct tcctaaaggt gaattaacac ggggcatggt
60541 tttatgaata aaagttgtta tccacttgct atctgagttg tgttagatca agcactggat
60601 tgaggggcga tggtgggatg gaggcaggtg gtctagctat ggctcagctc tgcccttgac
60661 catagctctc agaggcaagt caaattattt cttagcctta gcttcctccc tccaaaataa
60721 aacagtagta ccgacttgca gcaaaaaatg tcaagctcag aaatgctggg ccagacaaaa
60781 ggactttgta aaccataaac tgctaagcac gtaagagcta ctgttaggat ctcaaatagt
60841 atttcctcag gaatttcccc tcgctgcttc cagtgggacc tccaggactg gcatttatcc
60901 cattcccccg actgtcctct aaccttgatt ccccagggca aagcagagcc aagaggaatg
60961 gggagaaatg tcacctacat tcccctgtca ggacacaaga ggaagcacaa gttgagtgtg
61021 gctgcagggg acacaactct gcatgtgtat ttatttctac cccatcttgt agcagaagag
61081 atttagggca aactccaata tacacatgga gaagaggcag gaaaaagatc caaatgtcct
61141 catgttcctt tgttctgttc caaacaagga aacaaaaatc acaagcatgc acacgctgca
61201 tggtgagcct ggaattcccc agcaggtgac tgggctggga gggtccctgc tccatcaccc
61261 atctgcctgc cccatgagtc aggcccggaa tgagagctgt agaagccagt gtcatcatgg
61321 cagagcagtg aggggtaaaa actaaggggc agaccccaag aatgtctgcc ggggccactt
61381 cctcttctca gggacaagtt tgcccaggat cgttatggtc tacgcccacc tgccattcct
61441 caactcatgg ccccacccag gcactggctc ttcaaaggtg gttacactat tgggacatat
61501 ggtaaactga ggcccagagt ggtctgactc ttttctcaaa gtgacctggc aggtggagcc
61561 aggccggtgc cacccctcaa gctccgtctt gtgaggggct gcctaccaga agctggtcgc
61621 tgatcttgag cttctccatc tggatctccc gcagcggcct cttgagcagg gccttggtca
61681 tggcgttctg ggctgtcatg cgtgtggctg tgttcaggtc tttcacagtc atcaccgaca
61741 gcaccgggtc ccagatgcga aactggacat cggctcccac ggacagcaca gccccgtcct
61801 tagaggccag ctgttggggg aggccatgag agagagacac tcaaggggct gggggtgcag
61861 ggaggtcagg cccactgggg ccacccagct tgaaccacct gcttggcagc tagctcctca
61921 agggcaaatg gtgtcaccaa gtatgtaggg ttaggtgtat gaagcaagga tgtcctccta
61981 gcttccatca attttctggt ctcttcttcc cccttccccc ctcagatggt gactcacagg
62041 ctgaggtcct ggcaccacag tacattctgg acaggccccc agttcctctg tcaaggcagc
62101 tgagaagccc ctcaccttgc agggagggac gttgaaggct cgtgtcctca gatccaccct
62161 ctgaaaggag tcaatgaagg gcaagagcag aaccatgcca ggtccctggg gggtgcggat
62221 ccggcccagg cggaacacaa tcatccgctc gtaggtgggc acaatctgtc cacaatggca
62281 agggaaagag ttgaaagtgg tcagcctagg ctggccaatg ctgtctgcct aggtcccttc
62341 ctcacttctc tcctcctcac ctgggtcaca gttaggtatc cctagcactg tttccagatg
62401 agaaaaccaa ggctcaggga agctaagtga ctgctcaaaa attgcatagc cctaagtgaa
62461 atagtgaaga tttgaatgca gttctgaata actccaaagg ccatgtgtct taacYactgc
62521 actgtattga cttgatcctt agagaaactt ttcatctctg tggtctgaag ttagacatga
62581 ctcataccag gaaactgtct gtccttggat tagttaggag aaaaggctSg gctgccctaa
62641 cagcaccccc ggggaaaggg ctttgtcaac tttaggtccc tggacctcct agagaagtag
62701 tgatgtccaa attgagaaat gaaggcccag agaggcaaag aaacctgttc aaggtcacat 62761 ggcatttgtt tctgtggcag ttttagaact aggatataag gccatttaag gacccccttg
62821 cagaccacac caaacccaga ggttttctag agagggactg ttgcctaggg ctacacaaag
62881 ggcaaggcct ccttgggctt ccaccttccc ccagctttca cgtgcgatgc tgaactatag
62941 ctccatggtt catccttttc ccactgtacc accccttatg gaaaatgagg cctgaattcc
63001 tattatgcac taccagctgg gctaagttgg gtgttttcat ttctaattta ttctaaccca
63061 aagagaagat aatttggcaa agacatctgc gtgtacctta aagccagtgt ccagatccca
63121 ggacttagga gtttgggact tgcttctacc ccctactggc tcccagtatg actttagaca
63181 agcccaagcc ttagtttcct cccctgacca atgtgaatga atggttcttg cctagcccat
63241 tacacaaagg ggtaataata tttagggaaa ggggacagag gataggcaaa tttattcatc
63301 aatgccaaag ctctcagtgt ggcccaacca ccctgggggc tgacccagcc agccttacct
63361 tcagggcaaa ccagccagaa atggggaagg tgaccaacag cagcaagaac cccaggaaac
63421 tgatgaggcc atgacagagg caggagggcc agctctgggg tacatctgca ggtgagagca
63481 gaggtggtca actggacctg Nacgacagct gccaagcgga gtgaacttgg gcaagtgtac
63541 cttacgYcca ccttcccctc gagaggctcc ttccttctca gggctctcaa tctggctcct
63601 tgcctaatat tcccgtatct ttgggcagct gcaagttagg gtctgttccc tcctcccata
63661 catcaacact catttgtccc aagtccaaca accctcacaa ggccttattc tctgctaggc
63721 aacagccatt caatctcaga atccagtccg cgtgatgatg ctctcctcac tggactgagt
63781 aggggtcaat cctctcgttt aatttatatt gcctacccat acctggcatg gagccaggag
63841 cacctgggca tctgtaaaca tgcactgaat actgctggca aaacacattc ctcctatacc
63gθl atcagcccca gaagtgtgct ttccaggagt ccttatgaag atgatgcctt agcctacagg
63961 gataaatcat aaatagctta tcaacgggag ccacagatga ggaattagat tattattttc
64021 tattccacac ccaactttaa tgccttaatg accattaaaa aatgcctatt tcacgagatg
64081 gcgccactgc actccagcct gggggacaga gcgagactcc atctcaaaaa aacaacaaac
64141 aacaaaaaac aaaaacaaaa aaaaaccctg cctatttcaa ttcaagaaaa ttgttagggg
64201 tcggggtcag gggcagggct agaaagatga ggcttatcca agccaaatgt cctggcccct
64261 ggagattcag gagcccaagt tgggagcaaa gccgagacag ctccagaatc tgggatgagg
64321 ttatttgccg ctttcctccc aaccctggac aggaagcagt cgggagccct gctccattct
64381 tccaggaagc cctgccctct gggctaagcc ccagagcact gaggctccac tttgtgcctg
64441 gctctgatcc accaggcctc tcaagagact tctggatagg gagagctttc aggacaggaa
64501 ggccagggag ggatcaaatc caaggttagg cggttaggct gaacagcgtg ggatctggcc
64561 tgtaggccaa aggagccaca gaagactttg agggcaagac agaagcaggg cagatccaac
64621 aggcagctga ggacctgtca ttttggcctg cacatccagg agatgcctag ttcccgggct
64681 tctagaggtg ccccctaggg cgaaaattct tccatttccc tgcagcaggt gcctttaggg
64741 tgctggtggc ctcctctgcc tagacctcgg tttcttctat gcgaaataga aacctgaaac
64801 gtcttcccag gcctaaaggg ctgataagag ccgaggacaa atgtggtgag gtgaggtttt
64861 ggaagatagg agcaaSgctg gctggctctg gggccaaagc cccatgaccc tagggagggc
64921 ggatcggcgc tagcaccagg cgccgggtcc agccccctct ccacatcgta tccctttctc
64981 agtcccccct cgtagggtgc gacggcaccg ggccggccga ctcctcggag gcagagattc
65041 gggcctgggg gttgccggcc ggtccccccc ggStccgccg tgccaggcgg ccactcaccg
65101 gcccctgtcc ccacgccgcc ccgctccggg gacaagcagc ccttctgcga gcccagaaag
65161 ccgaagctcg actgctggaa gcggtcaaaa tcacccaggg gcagcgcccg gtacccagac
65221 ctgccgagca tggcttttga caggagacac gccccgcgcc tccgcgcggc gccctccctg
65281 gccagtgggc cctacgcggc cccgccctcc tggctgctgc ttccggcttc acccgcgcgg
65341 ccacccgcgg cggcgcgggc gcaggaagag gaggccggcc ggggcccgct tccgccgtcg
65401 catggctccc cctgcgctgg gaggaccgaa ctgcagccca gggctactgg gtgtgatcgg
65461 cgttcctcgg accccgctgg ggtcatcgcc tcctcccctc ttctcctact cagccctaga
65521 aaagctggag gggaagctgg gcacggtggc tcactcctat aatccatcaa tttgggagac
65581 tcaggcagga ggatcgcttg aggccaggaa ttcaggacca tcctgagcaa catagtgaga
65641 gcccatctct acaaaaaatt tttaaaaatt agcctggcgt gggatgcctg cctgtggtcc
65701 cagccacttg ggaggctgag gcgggaggat ctcttgagtc caggagtttg aggctgcagt
65761 gagctatgat cgtgccactg cactgcagtc ggagcgagag agcaagatct catcagggtt
65821 tacaggaagc caatcttctc caggatcaag gacatgctat atcagccttc tcagcactcc
65881 ttctctcaca ctggaggcag gacatgccat atctggactt tgggtttctc tgggacatag
65941 tctgcaaatt attcctcttt gtgaacccac agcccagcaa gcagggactg gcatagggca
66001 ggtctcaata cttatttgtt aagtaatggc ctggccaggt caccgtgatc aaggtggagt
66061 aggaaggcct gaactttggc acaaaaagaa agaagtttca catgcagact tcggggagca
66121 tgggagtgta aggaagaagg ggatagcaca gagctacatg agggcagggg ccccagagca
66181 ccacagaggt gaggccctca gtcctgcagg tccagaaaga gcatgcccct tgatccaggt
66241 acctggaatt aacttgcctc tccagggctt gagaaaacct gaatgcaact cgtgaatttc
66301 ctttgagaag tgttaacttc caacaggact ttggggtagt ctgggagcag gctatcttcc
66361 aaagcaagca aagaaatgaa taaagcttcc ccagctctgc ctcctcagcc aatcgcctct
66421 ggcctccgaa gccccatcct gccatagccc acttccaggt cccttgtgca gatggctgcc
66481 caccatattt ggctttcatg gactgattct ctaaaggcct gggagtactg accaggctgg
66541 agggaagggc aggctcctga ggccttacag tccctaggaa gttgcgtatc tgcccaaccc
66601 ctgctctcca ccctgcagac tgtaaggttt acaagagcca ggccctatca tcatcctttc 66661 tagtctgttt ctaagttgga acagagtacg gaatgggtac acaggagcca gcacagtggt
66721 tgcgatggtt taagtttgaa gccggggcgc tgacccagtg aggtcacctg gaactgtgcc
66781 cctttcccct taccagctgg gagtctgaca tgcttttcca ttggcgaaga cctagctggc
66841 tctcccctca ccctcttcat acccgctctc cagctctccc cctccctcct gcccccacca
66901 cctcagatcc accagccttt ccagctgtca ctcaaggcat catcctgctc cctcacctcc
66961 agtcactggc ttcccaggat ctctgaatca agtccctcct ctgcatccca cagccactgt
67021 cctagaccag ggcacctgct cctaggttgt cagagtgact gtcccatcat gcacagctga
67081 tcgtgttgtt ccctggttcc aaatccttca gcaacttccc atcactcaca gaactggttc
67141 aatctcctYa gctaggatct tgtcctagca cactccttgg gtatcatttc tcatgaattc
67201 cctcttaaat ctgaaaatgg ccaaaattag ttcccaaaca ggcttttgca agagctatct
67261 tttctgtttc aagtgtcccc cgtaccccac cacctacaac cctaaatccc tggtgaattt
67321 ccactgcttt tgcaggtccc agctgtgggc tctcctttcc agaatgtctc cgtttgcagg
67381 cttgctcttc cattacatct acggctctta gaaagcaggg gctgcgtgtg gctcatcttt
67441 gtacgcccag ctcccggcag gacgtggcac gaagcagtgc cagtgtgaac ggatgaatgg
67501 atcaaagccg ggagcagggc tgcccccctg cagctctgcc ctacctctYc cgctttaccg
67561 taagtcagcg gtaggtctgc agctctccgc ctctacctcc tccccgctct gggcgtgtct
67621 ttaaaaccca cagtcggcct ctctgccccc tagaaccgcc cccagcttct gtctcacttc
67681 ctctccagag gcgggccctg agccggcacc tcccctttcg gacagctcaa gggactcagc
67741 caactggctc acgcctcccc ttcagcttct cttcacgcac tccaagatct aaaccgagaa
67801 tcgaaactaa gctggggtcc atggagcctg cacccgcccg atctccgagg ccccagcagg
67861 accccgcccg gccccaggag cccaccatgc ctccccccga gaccccctct gaaggccgcc
67921 agcccagccc cagccccagc cctacagagg tactattggg ttaggggatg atggggttaa
67981 gctttgttgg tttgctgtgg tggggagagg cgggaagaga gggtctaacg gaggatttgg
68041 tcaagtaccc tagagagtga cacaaagcgg gaagtccaga caccagggtc ctgaccgtct
68101 cgggtggggc agggaaggga gggtaggata gagtagaaaa gaggacacgg aggagttggg
68161 gcggcctcgc tgggctgcgg tttctccact gagcagttgg gcaaggtgag aagggtcagt
68221 ggcctccggg cctgggccct tccgcccacc ctcgagccct gcctcaactt tgcctcagat
68281 gcaggacttc agattaggga ggatggaggt agtacccctg ttgcgctggc ctggagccag
68341 gggcatgtcc caggcacggc aaaactaaaa ccaacttccc agatccgagg tgagaaactg
68401 gctcagactg aagaggtatc tttgccaagg cctcccagct catgtggttt ctgcttaagg
68461 aagcctcccc aacgaaccct tctcttgcca cacctttcct gcccacctcc cacctccccc
68521 gacaaaggaa ctacttgggt ttcttgctct gctgcctttc aggccctttt actccccttc
68581 atgaaagtac agaggacacc gtattacagt aacttttata aacattatta caactaagaa
68641 taacattact taacaatact aggtaacatt tatgagcact tcaaatgtgc caggtactgt
68701 attaagcact ttggtttttt tttgttgttg tttgtttgtt ttgctttgtt ttttgtttgt
68761 ttgtttatct gtttgttttt gagacggagt ctcacactgt cgcccaggct ggagtgcaat
68821 ggtgcgatct cggctcactg caacctcctc cttccgggtt cacgccattc tcctgcctca
68881 gcctcccgag tagctgggat tacaggccac gccaccatac ctggctattt tttatatttt
68941 tagtagagat ggggtttcac tatgttggcc agattggtct ctaactcctg acctcgtgat
69001 ccacccacct cggcctccca aagtgctggg attacaggca tgagccacca tgcccggcct
69061 gtttttgtat tttacaaaat gtggtaaaat atacctaatg gataagttcc tatgttaacc
69121 atttataagt gtaccattca gtggcattaa gtagattcac aatattgtgt aaccatcacc
69181 accatctatt tccagaactt tttcattact ccagaaactc tgtactcttt aaaccatagg
69241 ggagggaaag atggcttgcc tccacccttc tagtttcctt ggctgggcta tgaattaaat
69301 agcctatgaa ttaaatagtc ataaaataga ttaccagcgg aaaacccata tttaattaca
69361 tatgtatact caggagtccc acaatatatg agactcaaag aaaggtcaga tgattgaagc
69421 ctgtataaca tcctgagcta cggaaaagag cttggagctt ctgggtgatg gtgataacac
69481 aagttatggg agggtgagga gaggagctgt ttggtgaata gaggttgtct tgctatgtag
69541 attaaaagtt cttagataat aaaagttgtc tggagcagcc ctcttttaat atagatcatt
69601 ttactaatgt agattttctt ttaagatata aatgcctttc ttttttacaa aaggagagct
69661 tttcagagct attcctgtat cagcagtttc tcagaataac cagcttaaaa tatgccaaag
69721 aagtatattt caagagcctc ctgcagtcat actttgaagt ggtgtgtcct gagccccagt
69781 aatgcaatag ctcctcattt tctccttccc ctagcccttg gtaacttcta atctaccttc
69841 tgtccctatg aacttactta ttctagatat ttcatgtaag tggaattgtt accagtagag
69901 gatcttgact gcaaattgtt caggttcttg gcattttgaa caaagaattg gacaaaatgt
69961 acagcaaagc aaggaaagag tgaagcaatg aaagcagaga tttattgaaa atgaaagtac
70021 accccacagg gtgggagcgg ctagagcagg gctcaaggac cccagttaca gaatcttctg
70081 ggttccaaat accccctaga ggtttcccat tggccacttg gtgttcaccc cattggttgc
70141 agaaagcaac caaccagacg tactttcaat tttccatctg ccctgcagga aatggggtga
70201 tttgcaaaga gagtagcctc tcttcctttt gttactgagg catggagagt tgcggttttc
70261 ctttcgattt agttctagga agtcagaggg aatcggcctt aggttccctg cctccagacc
70321 ctattctcct gcctcagaat catacagtgt ttgacctttt gtgactggct tatttcactt
70381 agcataatgt cattgaggtc tatctatgtt gtagcatgta tcagaatttc atttctttct
70441 aacgctgagt aatattccat tatatgtgta gaccacattt tgtttatcta ttcatctgtt
70501 gatggatact tggattgttt ctacattttg tctattgtga atagtgttgc tgtggacatt 70561 gttgtacaag tatctgtttg ggccttgttt ttacatcttt tggttatata tctaagagtg
70621 gaatttctgg gtcatattgt tgttccatgc ttacctcttt aatgaacccc caaactgtgc
70681 attaagcact ttatatgagg ttggtactta gtgtatctac cttccaaact gagttccttg
70741 aaggcagaat gtatcctaca cctcttatat ctcagagcct attactgtgg gtgatgagaa
70801 gtagatgctc aataaatggt gcagtgagag ctggagggcc tgaataaatg ggggtattgg
70861 ggtgctgata agccagggtt ttgcatcatc caatgactgg ctggaatgga atatgaggtc
70921 ctactccagg gtccagctgt aagggtggtt ggccggtagg tgggggcttt tgggacttct
70981 ccaggcctca cctgcctctc tggtccccca gcgagccccc gcttcggagg aggagttcca
71041 gtttctgcgc tgccagcaat gccaggcgga agccaagtgc ccgaagctgc tgccttgtct
71101 gcacacgctg tgctcaggat gcctggaggc gtcgggcatg cagtgcccca tctgccaggc
71161 gccctggccc ctaggtgcag acacacccgc cctggataac gtctttttcg agagtctgca
71221 gcggcgcctg tcggtgtacc ggcagattgt ggatgcgcag gctgtgtgca cccgctgcaa
71281 agagtcggcc gacttctggt gctttgagtg cgagcagctc ctctgcgcca agtgcttcga
71341 ggcacaccag tggttcctca agcacgaggc ccggccccta gcagagctgc gcaaccagtc
71401 ggtgcgtgag ttcctggacg gcacccgcaa gaccaacaac atcttctgct ccaaccccaa
71461 ccaccgcacc cctacgctga ccaggtgagt aggccggcac agggtggggt ggtgcatcca
71521 agtaccaggt agagggcgag aggagcaaag atccaaagag tcacacagct gaggacaagg
71581 agcttctggg gccttgcaac tctaaatgtg gtctgcagat atgcagtgtc cgtgttgatg
71641 accacaattt atgctgccaK tccccacgca ggtggatagt aagtttccag tttcctcctg
71701 taataaataa tgctgcagaa tcatctttgc atctttatcc agtaacttct ttaggataaa
71761 tttttagaag tgccactgct gggtgtaggg ggacgggaat tctacatttg atacatgtta
71821 ccaaactgcc ctttagaatt tagtggaatt ttccgagagc actgacacgg aatctcagta
71881 aggctggatt ctaggatcag agacaRgtag Ktagtttctg tctgaaaagt tgaaaccatt
71941 aacaccaggc agcgctatct gagaatgtct gtatggggaa aaaaaatcac atccagttgt
72001 aattattttt attaaacaga ttttaactca gttttttaat aggtaataca ttcgtacagt
72061 tcacgaacaa aatttgtaaa gaggagagag agagtgcaat cttctgtcca tgcccaactg
72121 cctaattccc accacttctc cctcttccca
CASPR4 genomic sequence (SEQ ID NO: 11)
>16: 76177651-76273450
1 ccatctcaaa aaaaaaaaaa aaaaaaaaaa aaacagaaaa gaaaaaatat atgaactctt
61 atgagctgta gatacacata gcaatgtgag ataaattgtg atattgcttc acagtcttta
121 aatggatctg tttgtaagca agcaaaaaat ttatttgaag agagggacta gagttaacag
181 ggaatttaat ttggtgcctc ttcaRagtgt acacccccat tccagttcat tttcaaataa
241 tcaacctgag aacaacattt ttaaaacact tgataacttg tatctcacat tctaccatgt
301 gacaattcaa tgacaacatc actccctttt ctctattccc tcttaccacg gctgcgatac
361 tgtgtcttag acatctgctt tttggctgct tcattcccca ggaggctaca ttttgcattt
421 ttcaatcttg gaagcagttc tgttcctttg aagtgtttct tcattgttcc ttaggaccta
481 gacaaaacta atacttccca ttcactttgc taattttcca tctttaattt atatacttta
541 ttaagtatat tttaaataga gacgagatta aaaaatattt acaactattc tgtaggttgc
601 ctgttcagtc tgatgatagt ttcttttgct gtgcagaagc tctctagttt aattagatcc
661 catttgtcta ttttggtttt tgttgtcatt gcttttggtg ttttagtcat gaagtctttg
721 cccatgccta ggtcctgaat ggtattgcct aggttttctt ctagggtttt tatggttata
781 ggtcttacgt ttaagtcttt aatccatctt gagttaattt ttgcataagg tgtgaggaag
841 ggattcagtt tcagctttct gcataYggct agccagtttt cccaacacca tttattaaat
901 agggaatcct ttccccattg cttgtttttg tcaggtttgt caaagatcag atggttgtag
961 atgtgtggcg ttatttctga ggcctctgtt ctgttccctt ggtctatata tctgttttga
1021 tatcagtacc atgctgtttt tgttactgta gccttgtagt atagtttgaa gtcaggtact
1081 gtgatggttc cagctttgtt cttttgctta ggattatctt ggctatgtgg gctctttttt
1141 ggttccatat gaaatttaaa gtattttttg ctaattctgt gaagaaagtc aatggagaaa
1201 ctaagatttg aagtggatac aattatattt cttaaaaact ctggccaggc gttgtggctc
1261 acacctgtaa tcccagcact ttgggaggcc aaggcgggtg gatcacgtga gatcaggagt
1321 tcaaaactag cctggccaac atggtgaaat cctgtctcta ctaaaaatac aaaaaattac
1381 ccgggtatag tggcggacac ctgtaatccc agctacttgc gaggctgagg caggagaatt
1441 gcttgaacct gggagactga ggttgcagtg agctgagatc acgccactgc actccttcct
1501 gggggacaga gtgagactcc gtctcaaaaa aaaaaaaaaa aaaacctaag agaatcatct
1561 gggtaattac tttttataaa ggtaattcag taatgcttct aacaacaaaa ttaattttta
1621 aattcttaag ttctcttcct agatataaat aactacatgg acaatgtaaa agaaatacaa
1681 acgccatttg taatagaatc caaactagat tagattggaa gttgggttta ttatttattg
1741 atttgcttaa tttatcttca tggaaatata tattctgaag ctactcttgt tgatcctgat
1801 atgctttttt gttattgttg tcttttatgt tttaattttt tgactttaag tttttttatc
1861 tttgtgcatt tacatttacc tttttagttt cgtgtcaaat tataaaaaat ttgctgaaat
1921 ttttttaaac ttttaggttc agggatacat gtgcaggttt gttgtatagt taaactcatg 1981 ttgtacagat tattttgtca gccaggtact aagcctggta cccaatagtt aatttttctg
2041 ctcctctctg tcttcccacc ctccattctc aagtaagccc cagtgtctgt tgttcccttc
2101 cttgtgttta tgagttctca tcatttagct cccacttata agtaggaaca tatagcattt
2161 ggttttctgt tcgtgcatta gtttgctaat gataatggcc tccagttcca tccatgttcc
2221 caaaacagac ataatctcat tcttttctta cggctgcata gtattacatg atgcatatgt
2281 atcacatttt ctttatccag tctttcattg atgggcattt atgttgattc catgtctttg
2341 ctattgtgac tagtgctgca gtaaacattt gcgtgcatgt gtctttgtgg tagaatgatt
2401 tctactattc tgggtatgta ctcagtagtg ggattgctgg gtcaaatggt tcttagctct
2461 ttgaggaatt gccatactgc tttccacaat ggttgaacta atttagactc ccaccaacag
2521 tgtataagta atccaaaaaa tgaaaagata tcaaggaaaa aaatgtaata gaatatgtac
2581 aagaaacaaa aaaagaacta tttagaatat tactaaagga catagaagaa cacttgatta
2641 aatgcaagga tgtatctgct tttgagtaaa agataatatt ataaagctat tcattctccc
2701 taaaatcatc catataaatg agatcattct gaatgtcata tagaaaaatg tatatgagaa
2761 ataactaagt taattagcaa aaacaataat ggtaaggaga atttacatgt tacaaaaaat
2821 ttattaatat atattaatta aaacttattg atactggcac attaaaatat ggtataagaa
2881 cacatgggac atctgttact atgtccaaat acatttaggg atttgcataa aatagataca
2941 gcattgaaaa gcttaataca tatttaagga aatatgtatt agtcaatatg gaaatcatag
3001 ccttctagaa aagtagataa cttgtttata tcaaaataga tttaatataa atatttaaaa
3061 gtaatacaga tgcagaaaaa agtattaaaa gaaaatatag gacaatgtaa agatacacat
3121 gtaatattgg acggggcctg tctttctagg caaagggaac caaacccaaa tgccataaag
3181 gaaaagatga aaaattagat aatatatgga aggctgcata aaaatataac atatataaca
3241 taaaagaaag ggtatacatt gggaaatatt tttagcctat atgatagcaa tgcccacatt
3301 tattcagcag cagcagtggt ctttggttaa gactgacatt ctgactgact gaataggctt
3361 cattcagcta catatttact tagatttaaa aataataaag ggcaggcaac cacacagcat
3421 gcacagcaac agcataatag atgttcagct atcatgaaca acttttaaat atcccaataa
3481 ctgtcactgg cttggtgggt gttattgaac aacttttaaa tatctgaata actgtcactg
3541 gcttagtggg tgtcgccacc acacatcagg aaagccatca gctccagggg tccttcagct
3601 cttacattac attagtgatg taacttctca gggatacttg ccaactgttc tccaatgtag
3661 ctggtatctt atcagtccta ggctattcac tgatttccag gttatgtctg tgatagctaa
3721 atttcactgt gcattctaat tctggtacct agggagactg tctagaggtg ggagcccaga
3781 tttttaaatt agaattttaa aaatattccc aagtgatttc aattagctgc aaagtatgag
3841 aaacattggg ttgctcagta atcttgacaa ccaggtacag gtttttagtt cagtacaaaa
3901 cataccagca ggatatccat tcatcttaga ttctcctgca cattctttga gttaatgttg
3961 caagaaggat ttggctaaag ataaagagta ggaaaaaagc tacagcttag agattaactc
4021 tatattccca ataataatga cacaattttc ttaatatcca aatctctgct tttacatgtg
4081 gtagctacta gccacacagg gtcactgaaa aggattataa gttattctac tataaagata
4141 catgcacacg tatgtttatt gcagcactat tcacaatagc aaagacttgg aaccaaccca
4201 aatgcccatc aRtcatagac tggataaaga aaatgtggca catatacact gtggaatact
4261 atgcagccct aaaaaatgag ttcatgtcct ttgcagggac atggatgaag ctggaaacca
4321 tcattctcag caaaccaaca caggaacaga aaaccaaata cagcatgttc tcactcataa
4381 gtgggagttg aacaatgaga acatatgggc acagggaggg gaacatcaca caccggggcc
4441 tgttgtgggg taaggggcaa ggggagggat agcattagga gaaataccta atgtagatga
4501 tgggttgatg ggtgcagcaa accaccatgg cacatgtata cctatgtaac aaacctgcac
4561 atcctgcacg tgtatcccag aacttaagta taataaaaaa ataaaattac attaattaaa
4621 ttaaaaataa agctcctcag tttacactcg ccccatttga agagctcaat ggctgcgtta
4681 gaccagtggt tactggatta gacagaacag ttatggaaca cttccatcat cacaaaaatt
4741 ctcaacatag tataagtatg aaactttcta aaaaacagta aaaaataaag ccttagtttt
4801 ttttgttttt tcgttttttg gttaaaaaaa aaagagccat tatataaaca ggcagttcat
4861 agaaaggaaa aaatgatata taaatatata aaagtatctt caacctcatt caaaatagaa
4921 ataacacatc ctaaaagatt ggaatgaaaa catttgaaac tgcaatattt tagacattat
4981 tttccaatgt gtgcaatata acaaaataat acgttctttc attttaagtt attcatttca
5041 tataattttt ctttaaaatt tttaagctac tgcatcacac ccatggtatt atggttactg
5101 ctgtttaata caagatagac agggttttcc agagaaatgg aaccaagtat atacatgaaa
5161 tgggaactgg tttatgcaat tatggagacc aagaagttct accatctgct gtcttttagc
5221 aggataacca ggaaagctgg tggtctaatt tagtctaagt ctgaagaccc aaggaccaga
5281 agctcagatg tccaaaggca gaagaacatg aatgcttcag ctcaagaaga gagagccagg
5341 cacagtagct catgcctgta atccctgccc tttgggaagc caaggtggga ggattacttg
5401 agcccagaag ttcaagagca acctgagcaa catagtgaaa ctccatctct acagaaaaca
5461 caaaaattaa ccaggtgggg tggtgcatgc ctgtagtccc agctactcag gaggctgagg
5521 caggaggatc gcttcagcct gggaagcaga tgttgcagtg agctgagatt gtgccactgt
5581 actccagtct gggcaacaga gtgagaccct gtttcaaaga gagggaggga gggagagaga
5641 gagagagagg atttgccctt tctcctccgt tttgttctat tttagccttc aatggattgg
5701 attatatctg cctacaatgg tgagggcagg tctctttact cagtctacca attcaaatgc
5761 aatctcttct ggaaacaccc tcacagacat actcagaaat aatattttgc cagctgtctg
5821 ggtacacctt tacctagtca tgtggaaata tcaaatgaac cctcacataa acaatagcta 5881 tctcctactt gttatacgat aatatctggt aacatttact gatagaataa agcRtacctt
5941 ggttgtcaat acaaagcatc acaacagatt attgttcaat attttagtag tttaaatcca
6001 tatatatagc tgtgtgggtt tcatatgtgc agcatgtcat ctaatctgag tgtattctga
6061 cagaaaaaaa aaaatcctta gttctggttc taaattgtcc tctgcgccag tgccccatca
6121 gagaaacaag ttacctcaga atgctagaac ttctgcaagg actgccctat agaattatgg
6181 aagcagtggg tatcttttgg gggctggagc cttgtaaaag gctcagccac taccaagtag
6241 cagcctgagg cagagcaaaa gtgggaagaa ataccctggt tcctcccttc ctttcacttg
6301 cagatctttt tcaagttccc agctggaagc tccttaatac aggagcctgg gacacagtcc
6361 acgtcactca gccctctaat gttttgggtc agagcaggga aagggtgaca cgtggttcta
6421 agtgaaacag aacgatgagg acagcctgaa gaaggtatgt tactaacgac aaattgcctc
6481 tatgagctgc tttttctttg cttatagaag aggatgcagg cagaatccaa gtacttactg
6541 agtgattcct cattcccttt cagttttgaa attgcatgct tccctttcaa cccataaaga
6601 aaatagatca atattttgat actgaggaaa ttgagattta agataagttt ccccctaaat
6661 ttatgttaac tagtgccaca tgtataaaat gttacattta gcgctcttct gtcctggtaa
6721 tatttatgag taggcaaagc tagccaagaa cagtctttca atgtcctgaa agaagggaat
6781 ccatgaaaaa tgctgaacca ttggtttagg gtcatttttg ccacataatc gacactgagt
6841 aagtagagtg gtgctctcct taatcaatta tcgattcaat tctttatttc tcaaaatatg
6901 tgttagagtt caaaacatag atttgctttc tatgtgggaa aaaatagcaa acatcttaca
6961 gatgatcaaa catcaaacat cttacacatg agctccagag ttcactgagg aggaccaggg
7021 tatatatgta ccttaataca catctgtttt cgttttttgt tttgttttgt tttgttttga
7081 aatggatctt cttctgtcgc ctgggctgga gtgcagtggc acgatcttgg ttgactgcaa
7141 cctccacctc ccggattcaa gcgactctcc tgcctcagcc tcctgagtag ctgggattac
7201 aggtgcgtgc ctcccgcctg gctaattttt gtaattttag tagaaacagg gtttcaccat
7261 gttatccagt ctggtctcga actcctgacc tgaggtgatc tgcccacgtc agcctcccaa
7321 aatgctggga ttacaggcat gagccaccac acctggcctg ttgtcacttc tgggacaagg
7381 ttacaacaca cacttggtat gcaaaggaaa gcacattact aagttttatt gaaatgtttt
7441 gcttagctgg aagatcttat ggctctgtcc agtcctaacc ttggcatatt tcactgatgg
7501 tttccttgtg caacacagct ccaagctcag gtgtttaatt gttgctctta agacattctc
7561 caaagtttct tgtactttcc tatttctctt ctgggtgata ctcttcagtt atctaaggca
7621 tgtctgccaa acaagcttta gttcatccct ttcaatcagg gctttccaaa cacaatcaag
7681 tcacttacct ctcaggtcca cttttgcccc tcacttttcc aatattcact taatcatctc
7741 taagttctta cttccaatga catctgtgat agtgttattt ccagggagtc tctgcattgc
7801 tttgcagggt ttgtataact ttaatcaacc gaatttccaa ttcacccatc tatttttgtt
7861 ctatttcatt ctacttatat gttggctgat aatggttgtg ttccagccca aatttttttt
7921 tttttttttt tgagacggag tcccactctg ttgcccaggc ttgaatgcag tggcgcaatc
7981 tcggttcact gcaagctccg cctcccaggt ccatgccatt ctcctgcctc agcctcccga
8041 gtacctggga ctacaggcgc ccgccaccag gcccagctaa tttttttttt tttttgtatt
8101 tttagtagag acagagtttc actgtgttag ccaggatggt ctcgatttcc tgacctcgtg
8161 atctgcccgc ctcggcctcc caaagtactg ggattacagg cgtgggccac cgtgccctgc
8221 tggtcccacc aaaatcttat cttgagttgt agctcgcatg atttccacgt gttgtgggag
8281 ggacccaatg tgagataatt gaatcacgtg ggcagtttcc cccatactgt tctcctggta
8341 gtgagtaagt ctcatgagat ctgatggttt tgtaaagggt ttcccctttc gcttggctct
8401 cattctgtct tttctgccac catgtaagac atgccttctg ccatgattgt gaggcctccc
8461 cagccacatg gaactaagtc cattaaacct ctttttcttt ataaattacc cagtcttgga
8521 tatgtcttta tcaacagcat gaaaatggac taatacattg gcctggtttc gaattatacc
8581 tttgacataa ataattactc aagtgctact ggctaaaatg catactatgt atattatctt
8641 tattgaaaag tgtacctatt tcttaaggct atgaattccc agaagataga aactccatgc
8701 tttgttgcta atgtggtttc gaagagatat tgataatatt atttgagtat aaagaaacac
8761 ttttcatgat tacttcgaat ctgaaataca ataatctgat gtgtctgctg gtttacagca
8821 caggggtcac tgtacaaact gagactatga gggtgtacat ctgatattcc acataaatat
8881 gtgaatatat tccatataaa taggtgaata tattccacat aaataggtga atatattcca
8941 cataaatagg tgaatatatt ccacataaat aggtgaatat attccacata aataggtgaa
9001 tatattccac ataaataggt gaatatattc cacatatata tgtgaaatat attccacata
9061 aatatgtgaa atatattcca cataaatatg tggagtatat ttcacaaaaa tatgtaaaag
9121 aaacattctt agtcataaaa accaggactt gaactacata gctttatcta tccatattcc
9181 caattgcctt tataagtcat acctctaaat tggccttgtc taagattttt tctttttatt
9241 attatctgca ctaaatttac tcctttcaga aatgttcaca aaaaatactt tgggtgactt
9301 agaagagcca tggttttagg aaaagattca aatgttagga catttgtcca gaagtagcta
9361 tgagtatgaa aggaggaaac tggacaggcg cagtggctca tctcatgcct gtaatctcag
9421 cactttggga ggccgaggca ggtggatcac ctgagctcag gagttcaaga ccagtctggc
9481 caacatggtg aaaccctatc tctactaaaa atacaaaaat tagccaggca tggtggcagg
9541 cgcctgtaat cccagctact tgggaggctg aggtggggga gtcacttgaa ctcgggaggt
9601 ggaggttgca atgagccaag atcacgccat tgcactccag cctgggtgac aagagtgaaa
9661 ctccatctca caaaaaaaaa aaaaaaaaga aaaggaaagg aaacaggaag ccaaaatact
9721 aagacatagc ctacagaatt gtgtctataa atcagagaga taagagatac agtccaaaat 9781 gaatcacttg ttttgtgtct aacaaataaa atttgtaatt ggcttttgaa taccattctt
9841 tcattttggg ttgcttcatg ttaatttctc atactgaaac gttgtctccc ttttgaagcc
9901 atgagcattt taagtaccta ataataggat tctttttcag taagtgagag aggagagaaa
9961 aattgctgga gcagtgaaaa gacatcctca gggggcaatc actttattac attatgttca
10021 gaataatcat gaatttgggt cgggctagag aatatcagtt tcagagaaaa gaatcttcta
10081 tttattttag cgagtttgtg gaaagttgca gaaaattatc ccaagagcta caaagcgatt
10141 atgttactaa ttccatcttt gtactctacc ctgaaataat gtaaaaaaat taatatatca
10201 ctttgaaaat caatttctga tccttaaatc agaataaata catgaattaa ttaaactcac
10261 agggaactgt gctcacctta aaactcttta tgtgaacaat gataggtaaa taatgaaatt
10321 tatctggatt ggaaataaat tggtctgtcc agccttcttg ttctcataaa atcaaattct
10381 ttgtatttat gtacacacaa acattgaatt tccgtgtaca ttactctcac tttcttagtt
10441 tgcatttttc aaaattttta gtctgtgaac atttaatcca tctaagttga ataaagtata
10501 tacttgacta tgacactatt attattatta ttattattat tattattatt attattattt
10561 gagagaagtc tcgctcttgt cccccaggct tgagtgcaat ggctcaatct cggctcacag
10621 caacctctgc ctcctgggtt caaatgattc tcctgcctct gcctctcaag tagctgggat
10681 taaggtgcct gccactatgc ctggctaatt tttgtctttt ttagtagaga tggggtttca
10741 ccatgttggc caggctggtc tcgaactcct gacctcaggt gatctgcccg ccttggcctc
10801 ccaaaatgct gggattacag gcgtcagcca tcacgcccgg ccagcagaac tttttttaag
10861 agaaattttc accaagaaga aagtactatt tgtgtgattt aaaggcacgt atttactagg
10921 tgcagtggct catgcctgta atcccagcac ttttggaggt tgaggcgggt ggataacttg
10981 acgtcagaag ttcgagacca gcctggttaa catggtaaaa ccctgtctcc actaaaatta
11041 caaaaatcag ccaggcgtgg tggcatgtgc ctgcagtccc agctactggg gaggctgagg
11101 caagagaatc acttgaacct gggaggggga ggttgcagta agctgagatc acgacactgc
11161 actccagcct aggtgacaga gcaaggctgt ctcagaaaaa ggcataaatt tatgaaatat
11221 atttattcta tctcgtccta ctttgaatat tgcatagggc tttgcactgg ggtcttttgt
11281 catgtaggaa agctgtgcga cttttcacgt tctagcacac agtagaacaa ggttggctct
11341 tacctttgct ccaggaaaag tccttgtgaa tcattctctt ctctcctcca ttgaagtccc
11401 cacccccagg ctcctgcatc agaagtgtag taaatgtgag tagatctaat aatctggggc
11461 tagggtagca aacatcatga acacaYtgtc tcattttctg cagggaagtt tacattggct
11521 atatggaaat agtgagcctc cttctgttgt gtgagccaag agtgacttga atagtcggat
11581 tgtcagttca aggtcagtgc tggagccaca gcactaaaaa gaaagatgag atggaaggcg
11641 atgaatagca gttaaggatg tcatctctgt tatcagattg catgcattca gatgcaggct
11701 ccatctcatg caagctgtgt gaccttgggc agttgctttt acctcctctg taaaataagc
11761 gtagcaatac tatacacatg aaagagtttg tgtgaaagtt aaatacaaaa ggagacaaga
11821 aggagcagga gaaagaggag gaggtggagg aggagagagt tagggggagg gagagaaaga
11881 gtgaggaaga gataaagggg aagggaaaaa agagggaaat aaagaaaagc aagcaaggaa
11941 gaaaaccttt atgcaattaa atgcaaaaaa aatacaactc atgcaaaatt aacatagatc
12001 tgaggttatc agcaattcag ctaaaaggtg agagtagatg tctcactgag tgcagcggtt
12061 ttcggaaagg aaatttgatg tggagtggaa aagagaaaac agcaaatact accccaagag
12121 aaagggaaag gactgcctaa cataaaggcc attcgagagc gtatgtgatg gagtgagagg
12181 attcaaatca cagttggctt ggaagagaca tgtcttctta ttataaagga agaaaaaaag
12241 taaagacagg tttagacttc agtctatata aaggaccttt catatgcaaa gagatcgtat
12301 atttactgag agcaaagagg gaggtgtgag aatggtacct ccttggaaaa gtatccccac
12361 acagtcggag agcccagcgt tggccaaagg gcatgaacag gtcacctgtg cagactgtga
12421 tatggccttc tgcagctgtg tgcaactgtg catacacagg aactgagggc atagacattt
12481 aggacccagg gttggaatcc acagggatac tgtgatggta ggacactagg acaaggacat
12541 ataggggctg gcaagagcat ggaggaagag aagtaccatg gagtcagaac catgtagaaa
12601 aggaagtgaa gtcagggagg gtgaggttga taggagattg tattagttag gattctccag
12661 agaaacaaaa ctaacaaggt ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
12721 gtgtgtgtac acatatacat acatgtatgg aggttgggag agatgggaga tttattttaa
12781 ggagttggct cgtgcaatcg acaggcttgg caagtccaaa atctgcaggg taggctggca
12841 ggcttaggac tcagggcaga gttgcagttt aagtccaaag gcagtgtgct ggcagaattc
12901 cctcttattc cagggaagtc agtctttttt ttcatatatt gagaccttca actgattaga
12961 tgaggcccac ccatactatg aagataattt gctttactta gtgtctatgg atttaaatat
13021 taatctcatt taaaaatacc tttaaagaaa catctagaat aatgtttggc caaatgtgtg
13081 ggtatggtag cctagtcaag gtgatgcata actttaacca tcacaaagat ggaaagtgtc
13141 taaggaagca tggagttact gaggctgaaa agcaaataaa aatggaatga tggaagagag
13201 tcggaaagat tcagtggtct atggtggaag aatagaatat acacgtttat aatttcaaag
13261 atggtgcaat gctaggaaat gattaagaag aaggtgtggg cagggaagtg ttgaagagga
13321 gtctgtgaaa gtcatttagg gtgttttatg ggtcaaccac aaggcttttg aagcagagag
13381 ttgcaagggg tgtgaagaaa tgacctgtgg tttgccagag gacctcagtc tggaggggca
13441 aagtttgcta tcaccagctg acactcataa aaaaggagaa taaatgtgtt ttctctccct
13501 catttttttc ttttggcacc tcatttttac aaggaagaaa taaaaattct ctgtaattga
13561 cagaagaact ataaaaatgc ttactgactc catggaaata tagcatgtgg gaaaagttag
13621 cacactgcac cttaggtccc agaatgttca tttggatttc aggtgggatg aattcaccat 13681 gctagtggca ttatgcaaag ctttgtctgt gcattgtccc acatttcatt tttctagaag
13741 aataaattaa agttttcagg agttacacac ctctcacaac taccaaccag tacctgctgg
13801 agtctggatt agaaacccag gctgctcgaa tccagagatc actctcaatt ctcattttat
13861 aacaatatta agagagtttc ttttgtttat tggagattct aaaaagaggg aggatgggag
13921 agggtgaggg atgaaaaatt acctatggga tacaatgtac actattcagg tgatggggac
13981 actaaaagcc cagaactcat tattgcacaa tatatccatg taacaatttt cagttatact
14041 ccctaaatct atcaaattaa aaaataaaaa aatataatga ggaccctgga tggcagaaaa
14101 aagatcgttg gaagaaagag aagacagcag tggaaaacca ggcctccaca tgttctttgt
14161 agtagccttt gtagtagcta atacggaagt cagatggagt tgaagaaggt gacagatatc
14221 tgtgattgtc aagggaagta tactgtttct ggcataggtg tataagacca ggatttgtat
14281 gtgctggtaa actccaggtc tgtccatatc acaggtcatg acatggaagt tctgggttta
14341 gaaatggaca gacaagggga cctttctgag tagaccttgg tgtaagtctt ggggtatccc
14401 tggcctcact gttgtgaatg gtctgtgtcc agtgtattct tgcagtctca gccctgacca
14461 cactccagct ttctaggtgc atctcacata ctttccttaa gattccatat agaacacagc
14521 ttttgaggga tgttgtgctc ctgcaaagtc tgtcctccat gtcagtgagg gagaaaaccc
14581 ggcccagctg ttctcaccta gggtcggcca agaggaggcc tgtgcatcaa gttcaggttt
14641 gcggaacagg aggaacctga gccatctttg tgtggtgaag aaactttatg tatcagagag
14701 agggcttcag ttctatggcc acttctacaa ctcacttgat ttgtgacttt gactcaaagt
14761 ttgtgacttc agactcaaaa tgtgattgag actcagtttc ctcatctgta aacttagggc
14821 ctctgggttc atgtgacctt tagggttacc ccggactcaa agatccatgc tcatgggatg
14881 ccttttgctc tgcaccattc cttgggtgtc atagggtcta actgaatccg agtcctactt
14941 tctggtactt aaaaatgact ccaattcaca gtgctacatg ggaaatggga ggaaagaatg
15001 cgagagaatc atggttgttg gctgtggcta tagaagcatg tσagggaagt tcatcctgaa
15061 agagaatgag attcacagaa actcttatat cttaccccac ctccctacaa tctggaggtt
15121 aggtagtttt cctctactaa ttctcattct atttataatt tttcatttca ttacaattgt
15181 aatttgtcaa atatattttc tcgtttaaac tttgtttggg gtttagagtt gatgttagtt
15241 ttatgttctt tttcctcctt taactgagtc aattccaaaa tgtactactc tttctctaac
15301 tgattttgtc ttaatattat cattctactt tgtacattgc agccggaggt cacgtcctaa
15361 ttaatcaaat gccattttat cattaatctg agaagcacca attaatcaag tttttcctcc
15421 cattgaaact ggtgattaac caagctgtga cactatcttt tgagtgactt tctatattct
15481 gcttctgatt tagtagttag gtgtacacat cagtttcaat cactactgac tgatcttagc
15541 tggttctgac caggacaatg gtccttatct tttcttcaaa ttgattcatg gatccgtaat
15601 attcttgctt cctgttctgt tcctgggtta atgatatgtg aaggatttct ctactcttaa
15661 gttcagattt tcaaagatat gcttaacttc tagataatgg tgtggatctt catgacctca
15721 gggtgtgaag tccttgacta cgagtatttt tgtctatcta ctttaatgac atttgcataa
15781 atcttgatgt aggatgtcag aattatgtgg tgaatgttgt gaatattttt tgagaaatta
15841 attttttcag ataaaacgca agtctgttgt agtatttcaa gatattagag ttcaattatg
15901 ctggaaaatg tgttcataaa ggccctatgc atttagaatt agtggcatac actaaagtta
15961 tttcattttg aataagatat aataactaga ggctttgtag tagctaatat ggaaatcagg
16021 tgaagttgaa gaaggtgaca gacatctgtg attgtcaagg gaagtatact gtttctggta
16081 taggcgtata ggaccaggat ttgtatgtgc tggtaaactc caggtctctc cgtatcacat
16141 aatcagtctc tcagtctcat tgataaaaat aaattgggga ttaagttccc aatgctttcc
16201 ttcagat tec aagattactt tgaaatcagt attgctatac tttaaaggga aattattaga
16261 gcatttttgt attctctatt ttttttctgc atttttcccc attttaaaaa tgcttgtgat
16321 tacttgaata gattcaagcg aagtgtaaca ataagatgac taagacatgg tttgaaacta
16381 aatgtgatcg ggggagtggt tttctttttc ttgaaaacat tcaccaattt ttttatttgt
16441 aagtagcgat actaccttta tatagctgaa gggctgtgtt cttaccatta gacggtgctt
16501 ggaacagaac accacgtact taaaccatcc ataaatattt aaaggttgtg attatgtcag
16561 cagttaccga gggtggaacc actgcgtgct caggaagtca tatatatagg atgcctcttc
16621 cacaccacaa gcatcaatat gtgtacctta gaatgccaag aaaaaattat gacctatcat
16681 gaactcattt actttctttt aagttagttg tctatcatct taggattatt gaacttccct
16741 ggatcttagt ctttcgtatt ctcctttgtc gccaggctct gcactttccc aagttttttc
16801 tccatacctt tgaaactctt tcctctattt cccattacca gttacacaca attacttttg
16861 cataaaactt ttttaggaag ttgttaatac tttcacacta tcttcctcta gatagattga
16921 atcagatgga ctgaatttta gaatctagta actttaaaga tgagaatcYt tctgtgtgtg
16981 tgtgtgagtt ggcattctcc aaacctcagc agctcttgca gctcttggag acattaacac
17041 agagattgtt gacatgtctt tggagtgagt cccgaaacct gacattgaac catcacacag
17101 tagcctccca gtgccccctc ccaccccagt gttttcccag aagagactct gagagacaca
17161 tggctctatc taggagaagt cacaatgata attctgatac tgtgctagtg gaaagaggat
17221 gcagatgacc aggaatacct gaggagttaa gttggaaagg cctctgaaat ttactgtagg
17281 atgtctagga ctcagcttct acttccttca ggtgatcgtc aatttcatct agataaccct
17341 tcaagggtaa aatctattta agagaattaa catgtggttt acctctaccc ctcacatttg
17401 tttaatcacc ttcacaaaga caaagtgaag aaactgtgta gggtatgtta tttacttaaa
17461 taaagggaac ggagatatgc acatatattt acatattttc ttatgctttt taaataaatg
17521 ggagga aat aattttttaa aagaaagtta cctgccgggt gcggtggctc acgcctgtaa 17581 tcccaggact ttgggaggcc aaggtggatg gatcacgaga tcaggagatc gagaccatcc
17641 tggctaacac ggtgaaaccc tgtctctact aaaaatacaa aaattagctg ggcgtggtgg
17701 tgggtgcctg tagtcccagc tactcgggag gctgaggcag gagaatggca ggtgaaccca
17761 ggaggcggag cttgcagtga gctgagatcg cgccactgcg ctctagcctg ggggacagag
17821 cgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaaaaa aagagaaagt tacctttatg
17881 ataaactata ggggagggat agaacagaga cagaagctag actttttttt aacatgcctt
17941 gtttttcaga ttttactgta gagtaatata cacaatttaa taattgtata caaaattaaa
18001 tataaagcca tttctaaaaa gcaaaagtaa aatggaacaa ataaactatt tgttgtttat
18061 ttcaactatt aagttgaagg cataaataca tagaaaggaa ttatttaaag tgactttaaa
18121 acagtaatct gtgtatttta ctgttttaga tcccattgcc aaaaaaatct taagctactt
18181 tcaatgatca catcttgcta atgacagcca tttttttact taaaatattg tgctgtgact
18241 cagaaactta tcctgataaa gcagttatgt gattatattg atattattgg aaataataat
18301 tttcaattta agagaaaaaa gaagcaaatc taaaatcaga aagattaagt agatatcata
18361 taaccctgtg tttgaattag atacatcaat atgaactctg aatatatttt ctcttaagaa
18421 aaatagaact atttcctagt ttggtttatc aaaaaaccat gactatgttt atcaagaaat
18481 tatcaaggaa aaatgatatc tcctagcacc tagactgagg gcactaaata ccactttcct
18541 ctaaaaggat ctagaattcc ttgcagtaaa agactggatc caaactgagc catcaaatat
18601 acaaataaat tgggattact ttataccaga aaacaagtat gttgtcaaag actactggag
18661 tgatgtcaaa aggactcagt ggttaatttg aaaagaattt cactggccaa atgaagtaat
18721 tgaaacatca ataataccag aaatggactg aaacatcaag ttaaacatta atgaatgcct
18781 tatagaacaa aacgtttctt atccatcttt atgggaagat gccagagaat caactcatta
18841 gtctgaacat tggtttgtaa aaggaaaaat caagcattta tcccactttt ttttttttaa
18901 ttactaaact gcatctcagg gtaaccaaat atttaatgaa agaaactttc ccattttgga
18961 agcactccag gtcagcatac aaaatttaag aatgttagaa taactccatt ttgtaaactc
19021 caatgaaata atgtacctag agaacatcag tgatggctca cattgaaaca gagacaacaa
19081 ggtaggaggt acctggaagt agacaatgtg tgcttcgaaa gattcttgcc aaagttctaa
19141 ctaccagttt ataataaata caggaacaga aaaaaaaaaa aaaaaacgta tcatgtaaca
19201 acagagggga acaatgagca aggtgggaaa cattatagaa caaatggggc catttttttt
19261 tcaatagttg attgaaagaa aaaggaagag tgatccataa atagagattt aagagaaaca
19321 gcaatcgaat gcaacacatg taaaattttg atatcccgat ttaaacaata ttgcatacac
19381 ttatatgcac atatactttt aagagataag cagtccacac aggatgctga taatacagaa
19441 ctattgtgaa attttagatg tgacaattgt gtttttgttt tataaggaat tctcattctt
19501 taaagataca ctttgagata tttacgcatg aaataatatg atgtctggga ctgaatttaa
19561 aataatcgag ttgtaaagat gataaacttg gaggggacat gggtgtaggc gaaataaaat
19621 tggtcctgag ttcgtctctg aaggtagatg tgtgtgagtt ttaaattctg ttctctctac
19681 ttggttctat gtttgaaaat gtccataata aaaatgttaa tgacagataa atgttttctc
19741 ctctttaaat ttttagtaaa gttctcagtt ttttgttttg ttttttgttt ttgtttgttt
19801 gttttgtttt ttgttattta tttatttatt tttttgagat ggagtctcgc cctgttgccc
19861 aggctggagt gcagtggcac tatcttggct cgctgcaacc tccgcctccc aggttcaagt
19921 gattctcctg cctcagcctc ctgagtagct gggattacag gcatgcacca ccatgcctgg
19981 ctaatttttg tatttctggt ggagatgagg tttcactatg ttggtcaggt tggtcttgaa
20041 atcctgacct tgtgatccac ccacctcggc ctcccaaagt gctgggatta caggcttgag
20101 ccaccgcgcc cagccaagtt cccagtctta tacaatacaa ctttacttgt aataagttaa
20161 ggctggcagt aatgagcacc atgaggacca agctgaataa aggatcaaga agaatgcgaa
20221 gttggttgcc tcagtaaggg atgaaaggag gccacccaca cccaagcgag gattcagcca
20281 gctctgataa agtgccatgt agctttggtt gtgactgact tgcttttcat tctcccgcac
20341 ttggagagtg tgggatggag aggcactgat gagttgatta atctccttgg tacctacctt
20401 aggagattcc gcgctcctct ctcaggaaca gtcatggtag gcgattggaa gtggccttgt
20461 tattagtcat gcttcatcat gacctcgaaa tcaccagttg tcatatagcc aggctttaag
20521 aattaatttt acaagcatat ataacacatt ttcaaataag cttttatttt actacagtta
20581 attatccata tttatagctc tgttgtttta tttccccaaa atacctaata taaggtaaaa
20641 ttagaaagta agaacaacag ggaaatcata tttttcaata catgagccaa atgtgaagta
20701 tttaaatttt ttaaaaaatc aatgagttaa tttacagtca gcattcaacc ggttgcaaca
20761 ttttttgaag gaaaatagcc taaggtataa atatagtgaa gatatacata tgaattattc
20821 tgacacctga caggtgcaac ttataaagta tgaaacagtt tacatgacag gagcataatt
20881 ataaatattt aaagatcctt tttttaaaca atataacgca ttttgttgat ttgccttgat
20941 gcttactcca gatttttccc agatttattt agagcagcaa gagctatgtg ataagtacag
21001 ctgattctca ctttccctga cagttatgtt ttataaagtt tccatggaca atgaattatc
21061 aaatactgaa ccattgctat gctatgtcat ctcacaggga ctgccttagg agggactaga
21121 gattgttttt aagataggat aaaaatacct tgttttttta ttttagcaat tttgattata
21181 aattcaaacc tgaaaaatac agagaaaata taaaaataga aacaactgta atttttcttc
21241 atgcaaaaat tatttatata tagcaatgtt tcctttcagt cttttctcat atttatacaa
21301 aaattaacac tttaattaga agtgtgtgtg tgtgtgtgtg tgtgtgtgtg tagagagagt
21361 gagttgattc tcattatgcg tggaaattat gttctataaa gttcctgtga acactgaatt
21421 agagagtagt gggtaaatac acaattagag tcccgtgagc ctctgactgc aatatttttg 21481 tccacccatc aatacgtaac cttgttttac gtatgtttct gtttaaagac accttatata
21541 gtctgtagtg ctgatttatt aatattgagc tcatggccaa cagcactata actcatgact
21601 gaatgaagct tccctaacac atattttctc cgtaaggtgc atggcagctt tcttgtactt
21661 aggaacataa ggcagtattt cagctctacg tttggggccc attttaaaca gggaaatcac
21721 caaaaaatgc acaaaaatgt gaaaaatgaa tagataatga aaaaaaacac ttgtttacag
21781 tattgtagct gaaacaggaa ggcagagtgc caccttgttt gaactcagtt ggaagcaggt
21841 acgttgggca gcccagagtc ttcactgctg tgggcacatt cacaaatgac cactgaagca
21901 cataaagctt tgatttgggg ttaaaaataa atcttagcta gtaggcaaat tcacaataca
21961 gtatctatga ataatgagaa agaactgtaa tttactattt gcctaaaaaa taccatatgg
22021 gtatagtata gctctattat attcttgcca cgtcttttat aatctgttta taaaaactag
22081 cctcgggcaa aatagtaaaa tgagcaattt tttaaaattg gaaactgccc tttgccttct
22141 cagtggtaca cattttttaa aaaaatttga tttgcttgct ctcagtttgg ggttaataag
22201 accaaaattt aaaatgcaag cttccaaaga taagaatcat gcattttgtt gaattgcctt
22261 tatgcttact ccagactttc ccagatttat ttagagcagt gagagctgtg tgataagtac
22321 agctgattac tgtcttattt acgttaattt tccagagcct aacctggtgc tagaaacata
22381 gtaggtactc aggagatact taggcacaat aagtgaattc atgtcatcag taatatatat
22441 cccaccatgg tgagtagaat ggccttccaa agatgttcac taccttaacg ttgggaccta
22501 taggtatgRt atctctataa aaaaggcata ttgggattgt agatggattt taggttgtta
22561 atcagatgat catagtaaga ttaccctgga ttacacaggt gggcccagtg taatcaccaa
22621 gggccttaaa agtcaaagga ggcctaaaag gagattcaga gggagaggag gctgtggaag
22681 gagaatagag ttatgcaatc tgtgaatgac tcaacttgct tttgttggct ttgaagatag
22741 aggaagggag ccataagcca aggaatttgt gcaacctctg caagctggaa aggacRagga
22801 aatgaattgt ctcataaagc ctccaaaaaa agcatgcatc ctgctgacat cttgatttca
22861 gcccagtgaa acctgtgtca gatttttgga ccacagaact gtaagataat aagtttgtgt
22921 tgtttttacc cacaaatttt tggcaatttg gtacactcca tgcctgagaa aattgataca
22981 cctaccacat gacatttata gtccgataag tgatatcaca aatttgaaaa tccattagga
23041 cacacagcaa tgaatattta tatgttaatg tcaaacatta tggtgaggac tggaactgat
23101 attttgagag aagctcattc tcagttctca aatctcatta tataatttgg cagctattca
23161 taaaactgat tgactgattt tgtaaatctt ttgcaaccaa tagtctctct tgctttaggg
23221 ctaaaataat tgattttctc tcattatttt gtcatttttg agtgcaagat aaattagtgc
23281 tttatatatt ttaaatcatg tactaagtaa tagcttggta tttataaaat gtttataatc
23341 aggctttgtg ataaaatatg gtaagatcaa tattacagta ctccaaaaaa gcaattgccc
23401 tctgaaactt cagaattaat gctcatgaaa taatcagcaa agaagaaatg aaaattaatg
23461 ttgttttaaa aaccattgaa catggacaaa atattaattg catattgtca gtcaacatga
23521 tttaatagtg gtttaaataa gggtggttat gttgtcataa gaaataagat gatatagaat
23581 acttatttta cttcctagta tataggctgt gctcaataaa tgtaaagtga ttgccgttat
23641 ttttgaggat gccattgtta ttataatgca aacacagaag ggatctattc ccctcttttg
23701 ttttctagac tggttgaaaa tattttattt tttaaaaagt attaatgtct gctgaaaccc
23761 aatactatgt aaatatttgt cattaacggg tgcttgccag tctattttgc cccatactca
23821 agggttttgt attttaccat cagtcactga cttgagagaa tacatgaaaa tcacccttaa
23881 gtgtgggtgg gttgtgatta ctttacaagt tcctactttg tggatttagc cagatcagca
23941 tcttgtggtg tcagagacat tactgggaca tttacccaaa gagttcatta cagcactgct
24001 gttcatttca tccatcctca gaaaggcagc agcatcgtgg agtgccagga attcactctc
24061 agaggaagtc agtgtttttc aaacattggt accataatca aaatgaaaaa caaacaaata
24121 aaaaacaact tttctccaca cagcaaaata ccattctttc ttacttgagg cagtaatgaa
24181 gtggttttga aacctttgaa aatgagcatt gtgtagaata ttgagtaaat ggatttgaaa
24241 caaatgaagg aaacattgat atggatttct agtgttttct ttaatgtatc agtcaattca
24301 cacaaggtaa aatgcacaca aagtaaacaa acaaaactta agctatctaa aagtcatctc
24361 ctgtaatact gtgatttgta ataatatttt atgcataatg tctgatatat aatagtaatt
24421 cctgttataa acacatatac atctattgat ttattgcctg tctatgctag gaaatgttct
24481 agacatttta gatgcatcta gatatttctt atgtaaatct aaatgatgga aatgttattt
24541 attgatattt tacatacaag gaaatgggaa tcagagactt ttgtaggtca tataattaag
24601 gcagtacctg actccaaagt acaagtctgt cccaacatgc tctgcttcca ttgtagaatt
24661 gttctttgtg tgctttaaat tataatattt aacaaggagt tctatgtcct tatagtaatt
24721 ctagagaaaa ggaaagtaat tctttaaaaa aggagaaaaa cttacatgta catttataat
24781 taatgttata tatgactaag ccaaaacctt atgtcattat aatataaaga acactgtcta
24841 gtatataata gagtataagt atgtgtaaat atattgtcac tgtaggaaat aaggaaaatg
24901 aatattgcta tatgttagag aaactcaaat gttaggaaat tagtccccag catgatgagc
24961 agaacaagct ttctgtatgt gtgctcaggc aatgcaaatg gttccatttg tctcatatag
25021 atgttaagta cgtgtcctga ctcatacaca ggcatgtata cacgtatcaa ctaaggcatc
25081 ttagtctgtt ttgtatctgc ctctgaaact aatgtcaaat caatgtcatg gaattctttc
25141 tgacagcatt tctggcaacg ttgcttgtgg ctcttcttcc actcagcgct ttgacagtgc
25201 tgtttagttt tttttgtttt tgcgtttttt gttttgtttt tgtttgagac agtatctccc
25261 tcttttgcct aggctggagt gcagtgacgt gatctcagct cactgcaaca tcctcatccc
25321 gagttcaagc aattctcatg cctcggcacc tggagtagca gggattacag gaatgtgcca 25381 ccaagcccaa ctattttttt ttcttttttc tttttagtag aaacagggtt tcgccatgtt
25441 gtccaggctg gtcttgaact cccggtgctg aattcctcat ctgcctgact cagcctccca
25501 aagtgctggg attacgggcg tgagccacca catccagcca acagtggtgt ttatgggaac
25561 ccgatctcag aatagtggcc tattctgtcc tcagatattc taattcttct ttctaatatg
25621 ctaccaaaac ccacatgttt tagtttgggt tcctctagaa gcagaacctg agacaagaat
25681 ttgagtgcaa gttatttatt tggaaggcaa tttcaagaaa taacagtagg aggggaggga
25741 agtgagacag agaagggaaa gtagttaata aggtttgcaa tttgagcaac tggagcttag
25801 ccccactggg gaattctagg agccagtata cttcgccatg tctcaatgta tccatcagag
25861 gagcaaggga gctggggtat ttatccatca tctccaggca gtcactggat gaggacttag
25921 ccttcctccc tgggagatgg acaaagccgt caggtaaact tgtgcactac tggatgctgg
25981 acttcagcaa gatgtttctg aaaatggcaa aaccttcagg tatatggtga agagtgggca
26041 tctcttacta cagtaactta tctattgtaa ctaattgtaa cttatctatt gtagctaatc
26101 tggtgaagtc ttcagttctt ttctttatcc ttgccttaga ggcctgtgtg agctgggcta
26161 tacatagaag attggggtct ggactatatc cttttgccag gacacttgtc tcctcctaaa
26221 aaccccacat gtaattgttt cctctgagaa aagctggtgt ttcttgtctc atcaggcgtt
26281 cacagccagg gaatctgttc atgaactgca acttaatgct atctcttctg gccccataaa
26341 taacaggtaa aaaaaaaaaa agccctgctt gttttaagca ggcattattc cttctcatca
26401 ttgcattact gattcaaatt gaaagcctgg aatgtggctt cacaggtagc ttactcacca
26461 aggttgtccc tgcccttatt attatgaaac aattctagga tttttatttc atccttagtc
26521 ctctttggct ctcttagcta acttgaatct ttcaagcact tctgggtttg cactatagga
26581 ctttaccctc ctcaagtctt gaatttcttt taattctcat taactgtttt ttttcttttt
26641 taaaaaattt tttgtgggta cataattggt gtatatattt atggggtaca tgagatgttt
26701 tgatatgggc atgcaatggg aaataagcac atcatagaga atggggtatc cattcactca
26761 agcacttatc ctttgagtca cagaccagcc aattacaatc tttaagttac tttaatatat
26821 acagttatta ttgactatag tcaccctatt gtgctatcaa atagtaggtc gtattctttc
26881 taactatggt tttgtacaca ttaactatcc ctacctagcc ccccactacc cttcccaatc
26941 ttttatctat tgatgttgac agcaaatcac actgactgct ggccaaagtg taaagatttc
27001 tcccgctcct ttgcatatga tgaggagcca aatgtggtaa acacttcctc catatgaact
27061 caaatgttcg catttgacgt ttcacatctc ttattatttt ctgggggaaa agtcaaccca
27121 cctccaatgt tctttcccac cagccacagt ctttctaatt tgtaactgac ttgtagaaat
27181 tgctaacgtt tctttttttg gaatgt tcca aagcatgcta acatttattt atctaaaata
27241 tcctgttatg caaaactttg tgcttggcct agtaaataaa gatctggctg gcattttatg
27301 ctcaaccagg ttgtcttgta tgctat tcaa catctaatca actcacgtgc agtatcagac
27361 tcacttaaga gcttgtgtaa agtgcagact ccaagatccc acttcggatc tacccaatca
27421 gaacctctga gtgtggggtc caggaacagt gttgtaagga gccctccatg tgatgtttga
27481 tgttcacatg aagcttgagt aacacaattc tatagctttg ctactcaatg tgtggttcta
27541 gcatcagcat catcagagag acaaaacttg ttagaaatac aggatctcag tcactgcttc
27601 agacgtcttg agtcagaatc tgcat ttaa tacgatccct gggtaattca cgtgcacacc
27661 caagtttgaa ttgctctgtt ccacaggact tagcttgtat tttcagtgtc aataaataat
27721 acgatgtatc aaattattca atataattag cattagataa gtatcctaat gtgtttgttt
27781 ttgagacaga gtctccctct gtcgcccagg ctggagtgaa gtggcacaat ctcggctcac
27841 tgcaacgagt tctgcctccc gggttcaagg gattctcctg cctcagcctc ccaagaagct
27901 gggattacag gcttgtgcca ccacacccag ctaatttttg tatttttagt agagatgggg
27961 tttcatcttg ttagccaggc ttgtcgtgaa ctcctgacct caagtgatct gcctgccttg
28021 gcctcccaaa ctgctgggat tacaggcatg agccactgtg cctgggtctt cctaatgtgt
28081 tttaaatgga gagttaYgtt aggaaaatgt tcctaaacat aacacacccc aaagaaaaac
28141 caatatgaac tcccaaatca ttggaaagcc acaaacctgg atattaagta tctagcatga
28201 gtcctaagaa agaaaaatag ctactagaga aataaggata cagaattccg caaatctact
28261 tcttacttca ttatatatat ttttt caag aagacaatgt aagactactc tgaatgattg
28321 gaacacgttc ttgaggaaat ggagggaaat atgtcccctc accacatgta gtgcagagat
28381 ttattttcta gtgaacacta gcagg ctgc tcaagtacat actgtcattc gggaaatgtg
28441 cctcagtcaa acacaaagaa aacataattt tttcttggag tgttgagtct ttagggagga
28501 gctctttttt gaaataacaa agggacatgg aatttggatt tttaaagctt gaacatgtcc
28561 tcattacctg ggcacagatt catttcttgt gcaaagatgt cccgagtctc acagcttgaa
28621 gatgcYtgtc aatgaatgaa aggtcgctgc agctgcagga gggaagtcaa agtgcttaca
28681 ccagagtccc tgctttatac cttgccatgc tttacgcctt tgcatcttgc ctcacctgag
28741 aggtaggttc ttagcataat gggcttatca tttttatcgt aagtatttta atgactttaa
28801 caagcacaat tgtctaaatt gtattctgac attgagctag tctttcctct gtYtttctga
28861 acatgactct taYagattct ccaccaaatt caccaactac attacaactt tttccattag
28921 gaaaccaaca aacccctatc tagcc tatc ttatggttgc tatggttatt ctcagccatc
28981 gatgatgatt ttactaccca ctgaaaagct ccggcctatg tcctatatag gaaatgtgat
29041 gaattgatta gtgaaattca gatgtggcat taatcatatc ccaagatggg aatggtgggg
29101 gtcaacaaat cctccctact ttatatgctg tcatttactt tacacttgta tttaccccag
29161 tgacaatgat agcaacccac attgct taag actatcattt tggaatttat atattcattc
29221 agtcagtctg tactgaacac tgggcattta tgatgtgttg ctgagtgtac agagatgaat 29281 gagacacagt cctgggcccc aaagtgctca cagcctcttg gggcttagag gcctgcaaat
29341 gaatggagat ccttgtgacc cagcacagag agtgccctaa ctgcctgtgg gatgaagcag
29401 gcatcagcaa ggacttcatg gggggtgggt gagaggagga ggatgaagac attcctggca
29461 gaaaaaaaaa aaattgaaag actcccattg tggggcagag ggtatcctgg gctgtgttcc
29521 ccactttcct aagaagagac ttcagcctgc ggtgctatga gaacatgcac taaaatctag
29581 aggtcctcga tgtctcttca gagaactgtt ggatctacca agaagctata aaatagctta
29641 aacattaggg gcttcaatga attcagagaa aaatatagtc aacacaattg ctttatttca
29701 ttttcgccaa cagaaactct attagactgt gaacgctttt gtgtgtctaa tattttccct
29761 gctggttttt cctttggata tgtgtcttca tggggatgaa caagcatgcc aaagaaaatc
29821 aaatagaaca gggagaaaag ttatgcctac ttattatggc aagctctggc ttctacaaca
29881 tctgaaaatt catgaggaaa tgtgtatctt taaaaattca acttatcatt tggcattcat
29941 cgtgagagac tctgatctgg gtggtagaat agagttggtc aggaatgttt atttattttg
30001 gaagttggcc ttgagcaagt tacttagtgt gtttaaatgg ggtttattct gtaaatcaca
30061 gatgctctgt cctttacttt gattgatatt ggaaaggttg gatttggaag tacactcaca
30121 cgtacacact tcatagtgtg aaaagtctaa aaaaRgcaaa tatgtcctct aaatgctaat
30181 taactgtgat aaaaatggaa aatcttgcat ttactggtat tgaattataa ttacaaaatg
30241 atttaataga tgggaatata actttaaata catgacacag aaaataattt cctaattttc
30301 actaattcct agagtgatgg gattatgagt aggctttttt cccccttctc ctttccccca
30361 aaattctata acgtatttaa gtgaggttta taatgaaagt tttcacttat ttaaacataa
30421 attacaattt gaaagaaaat agttttattg aaattcaact taaatatttt gatacctact
30481 taaatgttta attcaattaa aatgttaatc attaccaaag aagccctagg caatgtcagt
30541 aaatgaacgt gtagaactta gaaggactct gatttctgtg atgagtgata catcattccc
30601 atcttccttt cttgaaaagt gctcaagttg aaatcatcct tttatgtctt ctcccccagt
30661 ctaaactaac aggtcatagg tcctgtttac ttagggctct gtgactcctc ttttaccacc
30721 gtgataccag gatgaatacc tttctcctga tggagaatta atagaacaac taggcaattc
30781 ggtgggacca gagcccttaa acattcctct ttttcagaca aaattgYatg tttgaaacgg
30841 tttacttctg atggcaaaac gtgactctcc caatgaccat catgacaatc aatggaagcc
30901 aattgggagg cactgcagcc aggcttcaga gagatcacga ccttttgaag ctgcttaaat
30961 cagacttgaa gctgcttaga gggcatcagc agatttgata ttattaattt tttttaactt
31021 taccacttat caggccaaag attctttttt tttttttgag atgcagtctc tgtctgctgc
31081 ccaggctgga atgcaatggc gcaatcttgg ctcattgcaa cctctgcctc cagggttcaa
31141 gcaattctcc tgcctcagcc tcctgagtag ctgggattac aggcacgtgc caccacactg
31201 ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttggcag gctggtcttg
31261 aactcctgac cttgtgatcc acctgcctca gcctcccaaa gtgctggtat tacaggcgtg
31321 agccaccgcg cccggccaaa gattcttaaa atagggtgta ataaattatt ttattggaaa
31381 aaataatatt ttataagtat cttcagtaaa aatcaatgta tataaacacc attaggcagt
31441 tctattttgg tcacacaaat cggtaacagt caccagcatc actgtgtccc ctgaaaagat
31501 ctctggatgg tttttttttt tcgacaaggt cttgctctgt cgctcaggct ggagtgcggt
31561 ggagtgatct cagctcactg taacttccac ttcccgagtt caagtgatcc tcctgcctca
31621 gcctccctag tagctaggac tacaggtgtg tcccacaatg gccggttaat ttttgtattt
31681 ttagtagaga tggggtttca ccatgtttgg caggctggtc tcaaactcct gacctcaggt
31741 gatctgctgg cctcagcctc ccaaaatgcg aggattacag gcatgagcca ctgtgtctag
31801 cctggatggt ttttattaac ctgaacagtg gtgaaaaata aaataatctg gaccataaat
31861 aaggaaagac ctcaacatca actaaaacac agatatttat aaatgacttt gggatgtggc
31921 attcatttcc aaattttgct ttgttagacc ttaggYgttt atatagctaa aaaagtcaag
31981 gggatgactt cacttgaatt gtgcatattc atttgccatt taattcaata aagaacagca
32041 aatgtattga ttgcagtaac agttactgct gctgctcaca agccagacac caccagaaac
32101 acacctatag gcacactaag ttggccatac tacccggtgc aagggacagg atgcacccta
32161 tgtgagtatc ctaattttta tcaaggaggt aggaagaatg gggcaaaact aaagctgtaa
32221 gtggtgaaga gagagctgtt actcatgcta accaaagagg tggatgtcca gtcactttgc
32281 tggtttagac attactttag ttttgatctt cactcagaca tgattacaga gtggttttgt
32341 ttttgttttg ttccattaca gtggaagaat gaccttgtgt ggtgctggtg tcctgtgaaa
32401 ttgYttatat tcaatagtaa aacatcatcc tcactcacag ctgacagtgg tcaggagctg
32461 ctcccatctt tgtcagcatc cttcacctca tgcctactgt gtatcagcca gtgctaccag
32521 gcctgcacac acatcgctga ctgttcaaca cttcctgcaa agataggagg catccttctt
32581 cccaatgtgc acatcaaaca tccacatctc tcagaagtct ggtagcttgc ctatggccac
32641 acagaaaaga actaaagcta tttatcacaa gaataattag gtaaataagt aaatacacaa
32701 gaaacaacaa gaagctttaa aggaagcaga cacataaatg gttgagggaa accagagaga
32761 cttatggaac tcgatcactt gggacttaag caatggagag gaattcataa agaggtctca
32821 tgggtgggtg gcatcaggga aggattccag cttctatttg ggtaaacatg tgcacaaaga
32881 cccaggggcc tacaagagaa agaacaacaa acctttcacg gacataaggg aaggctttat
32941 gtcRtaggtg atacctgaac caagagtcca aagggcagag aacagtttcc aagcagagaa
33001 tccatggatt atgctggggt gggggttggt tggtagaaga caaaaaatga acaatgagaa
33061 ctgagaaaag ttgtggggta tgacagtcag aagaatgcta gtgatccccg agctaccaat
33121 gtcaggagaa ttatgaggaa agggattaaa tcataaaggg ttaaatttca gtgagaatgg 33181 gacaagcaga aacagtaacc attttctcct tttcaaggag ttagagggct gaaggcatgc
33241 gacagaggga aaagaagctt tggagtgtgg agacagcaca catcagatac gcagtgggtg
33301 ggtttgtttt cattattatg catttctagg aacagaatat atagcaactg ttacatacct
33361 aatggtagca gtaaatattt aacaattaac atttaacaag cctctggatg attctgatgc
33421 atactaaata aagagaacct ctgtatgcta gaaataataa ggcctggacc ataaagtact
33481 agtgctacag tcaattcata aatctgtcat ttcatgaata aaatttcatg gttgtaattg
33541 tagcattata agctttatgt gtgcatgtgt ttgtgtgtgt gtgtgtgtgt gtagagcgaa
33601 ggaaagagat ttcatgctaa aggaaacctt agaattcatg gactgcctag gttctctaac
33661 tttgtttagc atacatatat tagggttctc tagagggaca gaactaatag attatataca
33721 tatatatata tatatatata tatatatata tatatatata tatatatata tatatggagt
33781 ttattaagga gtattgactc acacaatcat aaggtgaggt ctgcaagctg aggagcaagg
33841 aagccagccc gagtσccaaa gctgaagaac ctggagtcca atgtttgaga gtaggaagca
33901 tccagcgtgg cagaaagaga taggccagag actaaaccag tctagtcttt ccatgttctt
33961 ctgcctgctt ttattctggc catgctggta gctgattaga tggtgcccac cctggttgag
34021 gatggttctg tctttcccag tccactgact caaatgttaa tctcctttgg caacaccctc
34081 tcagacacac ccaaaggcaa tactttgcat ccttcagtca atcaagttga cactcaatat
34141 taaccatcac aatacatgag aatcatccaa aggcttgtta agtgttgcgt gatactgcat
34201 tctgtgcacc taccgtgtct tccctaccca cttttccagc catggacact gaggttgctt
34261 tcaattctca gccaccgcac tgcaaagagc agctacatgc acgtcccttt tacacatgtg
34321 tcagaactac tttgagatag gtaactggag acacat tcac taggtagtag ggtatacaaa
34381 tactaaaaat tttactacat aacatgaggg gtgccgtcaa agagttataa cagtgtacac
34441 tcccaccatc aatacgtgag ttcctatatc cccacatttg tgccaacaca tgatactatc
34501 caactttctg attttgacag ctttttaagt acaaagcgat atatttttta tctttttaaa
34561 taatattggg tgcatatata tttgtatata tacatagaca catatatttg tacatatata
34621 tacttatata tttatctcac cttgtgatat ggtttggctg tgtcctcacc caaatctcac
34681 cttgaattgt aataatcccc cctgtgtcaa gggggggtcc aggtggagat aattgaatta
34741 tggggcagtt ttccccatac tgttcttgtg gtagtgaata agtctcaccg gatctgatag
34801 ttttataaat tggaattccc ctgcgcaagc tctcttgcct gccaccatgt aagatatgcc
34861 tttgcttctc ctttgcctgc tgccatgatt gtgaggcctc cccagccatg tggaactgtg
34921 agtcccttaa actgctttcc tttataaatt acccat ctc tagtgtggct ctattagcag
34981 catgaaaata gactaataca ctttgctaac tgtgtagtct tggataattc acttctttct
35041 gagtttcagt tctctcatca gtaaaatgaa gaaaaattaa gtacctctga tagaaaagcc
35101 atgaaatgag atgatgtgtg aaaagtaatt cacatgagct ctgcaaagca ataagctacc
35161 aaaatagtta tttgttttta ttctgggatt tgattaaaaa tattRtttct caaaaggcaa
35221 atttttYtaa agtacttagg gaactgaatt ataagaaaat tgtcaattat cagaattcag
35281 tttggggata ttcttatgag atttttggaa cccacaggga gagatcaaga atacctacac
35341 agttgacaat gtccaggtta agggaatttt ggtaaaggaa agagactaat agtagattaa
35401 aaaagagtat cttttgcatt tcctttttcg tttatagttt ctggtgtata tgtaacatat
35461 cattaaaaac tggtaataga agttaaaaag aaatctataa tcttatcact taaaagcact
35521 gctgtattaa aactttgatg catcttttgt tatgcttaac tgaataattt ataagtatgc
35581 tgatcacatt agtcatgtat cacacttaac taatgaagag agcatgctaa tttttcaata
35641 gtctctgcat aagtcatttt aattgcttca taatattcca tcaagtacat gttgctgggg
35701 taattatatt ttagtgctct ggactagaaa gtaattcagt atctataaaa atgtaaaaga
35761 ttaattatta atacaaacta Ytttaatcaa atggat ttag acaggttagc atatcttagt
35821 gtatagcaat gtgcttaata ataccttata tttgtacagc cccatagaga gtaaacactt
35881 tcaagcagcc ttgtgatctg gaccgtctgg gtattactgt tatgttatag atgaaggagc
35941 cagtcaaggc tatgtgttta agaatttgcc tttagatctg acctttgcaa gagccaatac
36001 tggggtgcaa tgtgatgttt tgatacttat atacat gtg gaatgatgaa acatatccat
36061 cacctcacat attttttgtg gtgggaacat ttaaaatcca ctcatttagc aaatttgaaa
36121 tatataatat attgcattcc ataaatatat acaattattt gtcaattaaa aataaaaatt
36181 cttgtaaatt taaattcctt acagatgctg gatattaggc ttctgtctga tgcatagttt
36241 gcacatattt tcttctattc tgtaagttgt ctgtttattg atgatttctt ttgctgtgca
36301 aaagctctta attttaacta gatcccattt gtcaatattt gattttgtcg tgattgcttt
36361 caatgtcttt gtcatgaaat ctttgcccat tgtatgtcca ggatggtgtt acctaggttg
36421 tcttcaaggg cttttttagt tttggatttt acatttaaat atttaacgca tattgagtta
36481 acttttgtat atggtgtaag gaaggggtcc agtttcggtt ttctacttat ggctagctgg
36541 ctatctcagc actatttatt gaataagggg tcctttccac gttgcttgtt tttgtaagct
36601 ttgtcaaaga tcaggtggtt gtaggtatgc agccttattt ctgggtactc tgttctgttc
36661 cactggtcta tgtgtctgtt tgataccatt accatggtgt tttggttact gtagcactgt
36721 agtacagttt gaagtcagat aacatgacgt ctccagcatt gttcctttgg attaggattg
36781 cctcggctat ttgggctctt ttttggttcc ttatgaatct taaaatagtt ttttctactt
36841 ctgtgaagaa tgtcattggt agtttgataa caatagtatt gaatctgtac attgctttgg
36901 gcagtacggc cattttaatg atagtgagtc ttcctatcta tgagcatgga atgtttttcc
36961 atttgtgcat gtcatttctg atttctttga gcagtgtttt gttactctca ttgtagagat
37021 cttttgcctc cctggttagc tgtattccta ggtatt ttat tctttttgag gtaattgcaa 37081 atgggattgc gtttctgatt tggctcttgg cttggttctt ggctgttatt ggtgtatagg
37141 aatgctagtg atttttggac attgattttg tatcctaaga gtttgctgaa gttgtttacc
37201 agctgaagga gcttttgggc tgagatgatg ggggtttcta gatatagaat catgtcatct
37261 gcaaacaggg atagtttgac ttcctctctt cctatttgga taccttttat ttctttctct
37321 tgcctgattg ctctggcaga cttctgatac tatgttgaac gagagtggtg agagggggca
37381 tccttgtctt gtggtggttt tcaaggggaa tgtttccagc tatggcccat tcactgtaat
37441 gt tgtctgtg ggtttgccat agatagcttt tattttgaag tatgttcctt caatacctag
37501 tt tattgagg attttttaac ttgaaaggat gttgaatttt attaaaagcc ttttccacat
37561 ctattgagat aatcatgtga tttttgtctt tagttctgtt tatgcgatga atcacactta
37621 ttgatttgca tatgttgaac caaccttgca tcccagagat gaagcctact tgattgtaat
37681 ggatttgctt tttgaagtgc ttctggattc agcttgcaag tattttgttg aggatttttg
37741 tatcagtgtt catcaaaaat attgtcctga agttttctat ttttgttgta tctctgccag
37801 gt tttggtat caggatgata tttacctcat agaataggtt ggagagaagt ccttcctcct
37861 cagttttttg gaaatcatat cattgggaat ggtaccagct cttctttgta catctggtag
37921 aattgagctg tgaatccgtc tggccctttt tggtcggtag gctgtttatt actgattcaa
37981 tt ttggagct cattattggt ctgttcaggg aatcaatttc ttccgggttt agtcttgtga
38041 ggctgtatat gtccaggaat ttagccatct caggttttct agtttgcgta tgtagaggtg
38101 tt cagagtag tttctgatgt ttctgatgtt tggtgttttt tttttctgtg aggtcagtgg
38161 aagtatctcc tttgtcactt ctaattgtgt ttatttggat cttctctttt ttcttcttta
38221 tt aatctagc tagcaaccta tcttatcaat ttttattatc ttactaatta aaaaacaacc
38281 tc ctgaattt gttgaacttt tgaatggctt ttcgtttctt gatttccttc agtttagctc
38341 tgattttggt tatttcttgt cttctgttag ctttggggtt gatttactct tgcttctcta
38401 at tatttcag ttgtgatgtt aggttgttaa ttttagatct ttataacttc ttgatggggc
38461 at gagtgcc atgaattttt gccttagctg cgtcccagag attctggtag gtcgtatctt
38521 tgttctcatt agtttcaaag aacttcttga tttcagcctt aatttcatta tttatgcaaa
38581 aatcattcag gagaatggtg tttaatttcc atgtaattgc atggttttga gcgatttttg
38641 tcagtcttct gtttttattg tgcgtggtct gagagtgtgt tttgtataag ttaggttctt
38701 ttgcatttgc tgaagattgt tttatgtgca attaagcaat caattttaga gtatgtacca
38761 tgtagcaatg ataacaacat atattctgta gtttttgggt gaagaaaaaa acaactccat
38821 taaaacgcgg gaaaaggaca tgaacactgt tgttgttgtt gggttttatt tttttttttt
38881 tt ttgagacg aagtctcgct ctgtctccgg ggctggagtg cagtggcgcg atctcgactc
38941 actgcaagct ccaccttcca ggttcacacc attctcctgc ctcagcctcc tgagtagctg
39001 ggactacagg cacctgccac cacacctggc aaattttttt gtatttttag tagagatggg
39061 gtttcattgt gttagccagg atggtctcga tctcctgacc tcgtgatcca cccacctcgg
39121 cc tcccaaag ggctgggatt acaggcttga gccactgcgc ccagccgtga acacttttct
39181 aaagaagtcg tatatatggc taacaagcat atgaagaaaa tcccaatatc actgatcatt
39241 agagaaatac aaatcaaagc cacaatgaga tatcatctca cacaagtcag aatggctatt
39301 at taaaaagt taaaaagtaa cagatgatga tgaggttgca gagaaaaggg aacacttata
39361 cactgttggt aggagtctaa attaattcaa ccattgtgga aaacagtatg gcaattcctc
39421 aaagagctaa gaacagaacc accatttggc ccaacaatcc cattactggg tatgtaccca
39481 gaagaatata aatcattcta ccacaaagac acatgcacgc aaatgtttat tgcagcacta
39541 gt cacaatag caaagacatg gaatcaacat aaatgcccat aagtgacaga ctggataaag
39601 aaaatatggt acatatacat cacagaatac tatgcagcca taagaaaaga atgagatcat
39661 gt cttttatg ggaacatgga tggagctgga ggccattatc attagcaaac taatgtagga
39721 acagaaaacc aaataccata tgttcttata agtggaagct aaatgatgag aactcataaa
39781 tacaaggaaa ggaacaacgg acactggggc ttacttgaga gtggagggtg ggaagatgga
39841 gacgagcaga aaaattaact attgggtacc aggcgtaata cgtgggtaac aaaataatct
39901 gtacaacatg agtttatata acaaacctac acatgcaccc ttgaacttaa aagttaaaaa
39961 aattcagtaa agtaaatgtt gtataataat ttgacatgaa attaaaaagg taaatgtaaa
40021 tgcacaaaga aaaaaactaa agtcaaaaaa attaaaaaat aaaagacata acaataacaa
40081 aaaagcatat caggatcacc gagagtagtt tcagaatata cacttccctg aagataaata
40141 taaataataa atcccagtct actctagttt ggtgacctct tacagagaac aataaagcaa
40201 tgctatcaca cacacacaga cacacacaca cacaaagagg tcaatattgg gacttctttc
40261 tccactgaac tttcttaata caacatcatt ctacttctta agttaaacaa cttaaagtag
40321 ggctaaccaa gggtctgaat tagaatctct cagcataagt gagtgttttg aaaatttgat
40381 aaattgctct taagtttctt aatacatata gaatctttat ataagattct gtaaacaact
40441 ttgtgagcat gcaatgaata atacatgaaa ttgcttataa aattaataga catagtaaag
40501 at ttaataca aaaattgtga atgtaagcac tcacattttg agatcttcaa aatttatgat
40561 aatggctttc tgctaatgaa tttaatagtg accacagtta ataataatgt actgtatatt
40621 tcaaaattgc taaaataata tatttttaat attttcataa cataaaaatg gtaactaatg
40681 aggtgatggg tgtattcatt agcttgatta actctttcta caatgtatgc aaaaatcaaa
40741 acatcacatt gtaccccata aatatgcaca attatttgtt gtaaccttaa aatagataaa
40801 tt caaaaaac ttatgacaaa tgtatgataa atgcatgtat ttcaaatgag gaaaatcatt
40861 taatttcttg aactctgaat agaaaatgac acagaattaa gattgctgta atgtagttgt
40921 taaagagttt ctcattgata gacttgtttt cactatgaca cttataaaca cttaaccctt 40981 gctatgaaac ataacattag gttacattat tctagagacc atcttaaaac catgcgagta
41041 ttgtaattgt tYtttcccag tagctattta gatctgatca ctataattgc taagtaaaat
41101 aaaacaggga attgcaactt tccaaatcat caatttctaa ataaatttta gttgactttt
41161 ggataacaca gggaggaggg gaaacccatg caatggaaaa ttcatgtata acctttgata
41221 ccccaaaaag gtaactgcta atagcttact gttgactgga agctattttg tattttgtat
41281 atgagttata tactgtattc ttacaacaaa gcaagctaga gaaaagaaaa ctgtaagaaa
41341 atcataagga agagaaaaaa tacttactct tcattaacta gaagtgagtc atcatagaat
41401 cttcatcctc attgtcttcg tgttgagtag tctgaggagg aggagggaga ggaggggttg
41461 gtcttgctgt tcacgggtgg cagaggcaga agaaaacctg catatatgtg gaccctcaga
41521 gttcaaaacc atgaggttca ggggtcaact gtattttgga aacatatgca tagcatgtaa
41581 attgtctcct ttttttttta catagctaaa gaatatgact tatagaaact gataatttta
41641 tgaaacataa tcaatctcaa ttactaaatg aaatacgttt ttgtgctgca ttagaagcca
41701 ttaagttggg ccaggtgcag tggctcacac ctataatcca ccactttggg aggcagaagc
41761 aggcagatcg cttgagctca ggagtttgag accatcctga gcaacatggt gaaactatgt
41821 ctgtacaaaa aatacaaaga aaaaaaaatt aggcgggtgt ggtggcttac gcctgtagtc
41881 ctagttactg ttagtgctat tttacaacag catgtgctca ctttgtgtct ctgtgtcaca
41941 ttttggtaat tcttgcaata tttcaagctt ttaaattatt attatatgt t acggtgatct
42001 gcaatcagtg atgtttgatg ttactattgt aatatcacgc cacaaaccat gttcatattc
42061 agcagcaaac ttaatggata aatgtgtgtg ttctgactcc tccaccaact ggctgttccc
42121 gcatctctct ctctctcctt ggacctccct atttcctgag agacaacaat attgaaatta
42181 gaccaattaa taaccttaca atggcctcta agtattcaag tgaaaggaag agtcatgtgt
42241 ctttcatttt aagtcaaaaa ctagaaatga ctgcacttag gaagacattg tccaccaaga
42301 taagcagaaa gctaggcttc ttgcagcaaa catttagcca agttgtgaat gcaaagaaaa
42361 agtttgtgaa gagaataaaa agtgctactt cagtgaacac atgaatgata agaaagtgaa
42421 ataaccctat tgctgatacg aagacagttt tagtggtctg gatagaagat caaatcagcc
42481 actacattcc cttaagccaa agcctgatca aggccctaag ttcttttcaa ttctatgaag
42541 gctgagagag gtgaggaagc tgtagcagaa agctggaagc tagcagaggt tggttcatga
42601 ggttcaagaa aagaggctgt ctccataaca tagaagtaca aggtgaagc gcaaatcctt
42661 aggatgaagc tgcagtaagt tatccagaag atgtagctaa gatcataggt aaaggtggct
42721 acactaaaca acagattttc agcatagatg aaacagcctt ctattggaag atgccatcta
42781 gaactttcat agctagagag gagaagtcaa tgtgtgactt caaaggacag gctgactctc
42841 ttgtcagaga ctaatgcagt tggtgacttt aagctgaaga cagtgctcat ttaccattct
42901 gaaaatccta ggacacgtaa gaattatgct aaattcttct ctgtaaagca caggcagatg
42961 acagcacatc tgtttgcaac atggtttact gaatatttga aacccactat tgaagcctac
43021 cgggctcaaa tagtctgcct gccttggcct cccaaagtgc tgggattaca ggcaagagcc
43081 actgtgtcta gcccttgttt ttgaagaaat acattttgta aggctatagc tcttattgat
43141 actgattcct ccaattaatc tgggcaaagt aaatttaaaa ccttctggaa agcagtcacc
43201 atcctagatg ctattaagaa catttgtaac tcatgagaga aggtaaaaat atcagcatta
43261 atgggcattt ggaagaagct gattccaacc cttagggatg actttgaggg gttcaagact
43321 tcagtggagg aaggaactgc ggatgtggtg aaaatagcaa gagaactaga attagaattg
43381 gagcctaaag atgtgactga attgctgcaa tcttataata aaacattaat ggatgaggag
43441 ttgcttctta tgaatgagag aagaaagtgg tttcttgaga tggaatctac tcctggtgaa
43501 gatgctatga acatagttga aatgacaaca aaggatttag aatattacat gaacttagtt
43561 gataaagcag tggcagggtt tgagaggatt gactttaatt ttcaagtttg gctatgggtg
43621 aaatatcaaa tggcatcaca tgctacagag aagtctttca tgaaaggaag aattaatgtg
43681 gcaaacttca ttgttttttt aaaaattcac tccacagtca ccccaacctt cagcaaccac
43741 caccctgatc agtcagcagc gatcaatatc gaggcaagaa cctctaccag gaaaaagatt
43801 aaaatttact gaagactgag attatgatta gtattttttt tagcaatcaa gtattttaaa
43861 attaaggcat atacattttt aaggcatata gctattatac acttactaaa atataaagat
43921 actatttata tgcactagga aacaaaaaac ttgatgtgat gaaatttatt gcaaaatatt
43981 cactttattg tggtagtctg gaaccgaatc cacagtacct ctgaagtgtc tgtacctatg
44041 ataagtaaag aaatgttata aaggaatata ttagcttgta aattactaag cttcttacat
44101 agaactaatt taattaagct attgcttaac aattaacagt tgttaatcta ttaacaatta
44161 acagttgtta atctattaac aattaacaac caccacccac attcactaga tacacacaag
44221 taaacagagt agcaaaacca accctcttgt acccattccg aggtcccaag catcaacccc
44281 atggcctttt ctcccccgtg caactctttc atacgttgcc catgatctgt attattttga
44341 agcaaattta aaacttccta gctttatatc cttaaatatt tgtgtgcaaa ttcctgaaat
44401 ttaagattct attttcttaa aatagaatct aaagaagtga acaataattt atttgcacca
44461 tcaaataatc agttgttttt caaattttca atagttaact ggaaaacagc attttattat
44521 tactattttt ttaacaacaa ctttccaaag acctcaatat gatacaaaag agaatttctt
44581 agtaaggact attgatttca gagtccattc tctgaacatg ttctctgtgt agttttacct
44641 catccactat ctgccactca atcaagattt gagtccctga ggaattgctg aaggtacata
44701 tattcagaga agatgcttat tcctattctt acagagccat ggttttcaaa cctgcgggaa
44761 caaagccaca atgagtcatt atgtctgtta ttcttttttt cattactata catttgtggc
44821 ctaagatttt gtgactgtcc tggaagaatt caaaggaaaa tttgaatgta tggcacaata 44881 ggctttacac tacatgtggc attaagataa atatcattta agtgtaaaat aagccctaat
44941 actgtgtcat cagaatacta aagaattccc cctcagatac atttatttta atttt tttaa
45001 tctttaggga gcagcaaggc gttttatctg gttccttaca gaaacactta Yggtt attct
45061 atatattatg aataatgtag tttcttaaaa ttaaaataag cagagtttaa agtacgtata
45121 cagcatcatt aaaataacat gcaatatgtt ttataaagtg acttcagagg atgcatacaa
45181 atatctataa aagttatgta tgcaccttta aaataatttg aaaatgttga tcaaccaatc
45241 taaactgcgt tgaaatagaa acaatatgga tatttaggaa cttctggttg ctgcatggta
45301 ctataattac actggctgaa gtataatttc caaaaattat atgcaaaggc aaact agtta
45361 aaaagaaaat aaaactctac agtaaagaaa ttaaaactat ttttgttgaa gtaac tttcc
45421 taggaagtat tctattggta tcttttgtct tgaggttaaa aatattgtct actatgttta
45481 aataattatt tggctttatt tcccaaatgg aattgtcact ttgatcaaag catatagaga
45541 ggcgttgcta tttctccttt tactctctag tggggtgact tggatgttaa actcaagtaa
45601 tgagattcag agattaataa actgtctgta acactgtgcc atctgtgaag acttaatcac
45661 tatacaacac aacaatcaca actgcatgtt attgaggctt gttatgaagg aggcagatgt
45721 taatctcttc atcttactta atttggatat cagactttgg aagtaagtat tcttatctcc
45781 aatttataga taaagaaact gaggtttagg aatctgattc aagattttcc agctgttaag
45841 tgatggatcc ccatctttta agagccagga ttgtcttatt attttttttc caggt catac
45901 taaggtctcc agtacaaaag tttggatgag catacttaat ttctctttat ggaaagggct
45961 tgaagggagt attaatattt cacttgttgc tggaataatg attgttgatg tttgaaaaaa
46021 atgttgtcta caaagattRa gaagattttt tgtgaacatg aaataaatga gattt tgtca
46081 tctgtgttga gtagaagaaa tatttcccaa atttcagaca tcctagcatt aaaaatggag
46141 aacatgtatt aaagccttca agctttctct gttcttgttt catttatcta tatcaagata
46201 cccatgggta tgtgagccat ttactggttg gttttgtagt tttgttacat ctggcagtgt
46261 ttcaaaaggt aatgcaagtg ggcaggtgtt attattgatt gaaataagca gtttacacca
46321 gtctaaaaca gtgtccgctg catgcattta ttcaccctct gctcccaaat gacagatgag
46381 tttgtctttg tgaagaatag gttaagccct gattacatta ttactaaata aaatactctc
46441 tcttttgact ttctctataa tgaaacttta attatgtgac taaattgtac agaat ctgaa
46501 ggtcagaaaa cccaaaataa cacaccatca tacatttctc tgtgtgtcct aaaaacattt
46561 ggtaaaattt aaagttggtg gcaacttaaa aaataatact gtagagataa ttaat ttttg
46621 tattcactaa atcttaatat tacaattggg catgtctcag aggttaccga gtttctccca
46681 gtgtctagct tctatgaaag tataggttaa gatctacata aagatacagt ggtac tcagg
46741 taaataagac atatagtgtc taatgtacat cacaatatac attataatat gaagt ataca
46801 ttaatgtaca tccatacata cactagtatc attattaata tacattaaat aatat atggc
46861 ttcagaggcc gtgatgaggg tcatcagttc tgaactctat gaaacagtaa gggctgattc
46921 aactctatcc aaacttttta aacattctaa tttttcaaat taaatataat aaactggata
46981 tttattttaa tctgcttaga aatgttggtt gattgcgagt ctctttctaa agcacatatt
47041 taagtttcca tttgggaaaa caattagcaa tttaataaat aaatgacatt ttgaagtaga
47101 ctgaaggcta atcaatatat tagaatgact gtataaaaac aatagaatat acaggtaaat
47161 gaggaataat ttactttaaa ttttataatg tctgtagtgg ggaattcagt agttt tcttt
47221 cagcactgaa caatagtgat tttgatggta atggtcataa gaatgccatt attctYagta
47281 atattaatgg taaaatgaga gatgctaatt gagctcttta tggtataatg catgataaat
47341 tatgtgatat ctaaaatatg aagttgaaag gtatttctca tagtgttctt aatgatctat
47401 aaaaaagcac aaaagtgaaa aatagaattt taatgaggta ttcttaaaaa aatct tctat
47461 ttttgctttt ggataaatac atgcaaaatt taaatcttga ttgtctttgc tgaactattt
47521 tttaaagtgc caaggaccta tttctttttc atagttagca tgcttatttt catgt aactt
47581 tttataatga aagacaatac acattcagaa aaagacaaaa agcataaatg tatat acaac
47641 tcattggact atcaaaaagt gaaaatgcta tgtaaatRtt acgtaggcca aacatattat
47701 tgtaactttc atgccYttac tgttgactct tacctccctc ttcccaccaa ataat catga
47761 ccatgaattc tattgccata gattagtttt gcttattttg aattatatac agaaggaatc
47821 atactatatg aacttttaaa tatctggctc cttgggttaa catcatgctt atgaaaaaca
47881 cccatgttgt gt ctacatag gtataactga tttattttta tataatgaaa tgtcctacag
47941 taatgaaaat aagtaaaagt ataaacaata caattaaaaa tataatttaa aaatatagca
48001 gtatttaaaa at ccattcta taattggaca tatgaattat actttgggtc aattatgaat
48061 aatgcttcaa aaatattcac gtacatacat gtcttttgct agctggaaaa ctgcc tgatt
48121 ttgcgctggg tacatcattc ttcagagtgg aattgccaac tcataaaaaa tgtatatatt
48181 taattttagt agaaaatgca aactaatttt aatggaaatt ataccaattt atattctcaa
48241 cagcagtgta tt aaaattcc atttgttcca cattcttgaa aacacttggt attaattttc
48301 ttttgtttta gatgtttatt gttaccctca tttttagcca ttctagttgg tgtgcataac
48361 tctcacactt tggttctaat tggcattgtc caatgtctaa taagattagc aaatatttcg
48421 tagatttgtt aggcatttaa atactttttt ctcttttttt ctctcattgc tttgtagttc
48481 actatgtatt ctggatacta atatactgaa aaataggttc taccattctg tggtt tcttt
48541 ctattataac at tttaaat gaacaaagtt cttaatgtat tctgacatca gtttσctttc
48601 atggttaaga aaatcgttga actccttaaa atcgtgaaaa tattcagcta tgttatcttc
48661 ctataacatt ac tgttttgc ctttcacatt tatgtctaca gtcttcctgg aattcacttc
48721 tgcatacggt ttgaggtagt gatcaatcct tctttaaaaa tttctttctt tttaattttt 48781 tatgggtatg tgaaatgttt tgatacatgc atgcagtgtg aactaagcac atcatggatg
48841 gggttatcca ttccctcaag tgtttatcct ttgagttaca aacaatccga gtatactttt
48901 taagttactt taaaatgtac agttattatt gactatagtc accctgttgt gctatcaaat
48961 aataggtctt agtcattctt tctgtttgtt tgtacccgtt aaccatcccc acctccctgc
49021 aagcccccca ctacacttct cagcctctag taaccatctg tctactctct atgtccatga
49081 actcaacttt tttgafctttt agatttttct ttttaaattg ttttccaatg tggatatcca
49141 atttatacag caccatgtat ttaaaagaat tatttttctc cccactgctc tgcatggcaa
49201 acattgttaa taatccactc tccatacatg ctgaatctgt ttctggattc tctgatctgt
49261 tccagtgatc tgtttgaaga acctgccaat aagacattct cttattttct ataacattat
49321 aagacttaat atccagtaaa aaaaaaaccc tccaactttg tttttcttga ggagtatctt
49381 ggtgatttcc attttgttac atttccacat aaaacttgta actatcttgt aatttgtgca
49441 cacacacaaa cattggtttg aatttggtag aatctatata ttaatttagg agtattgaca
49501 tcttttcaat atgtattttc tactataaac ctttaaaatt tttctcaata ttttataatt
49561 ttcatgtaaa ggcattaaat atattttatt agttttttac agttaaataa tatagtttga
49621 tactaatgta aatgtcattc aaaaatttca ctttctgttg cttttgtata aatgtttaat
49681 tcatttttat atatagactt ttatctaaca gacttgctaa actaattcta tagatttttc
49741 aaatttccta catttgcact catacaccta taaataaagg cagttttatt tcttcctttc
49801 caatcctact acctgttaaa tatttttctt gccttattac actaactaga agttcattac
49861 atatttaatg aaagggtcta tacagaacat acttgtcaca ttctcaaaca caaagcagct
49921 ctcagcattt cctataatgt atgatacttg ctgtatgatt tttacagata ctctttgcag
49981 agttagacat tgcctgctgg gctaagaatt ttaatcctgt gtgaatatta cattttatga
50041 aatgcttttt ctgtatttgg tgagaaaacc atatgttact taatgtgata aattacattg
50101 aatgactttt aaatat aag caattcttgc attcctggaa ttaactcgat tgagatatga
50161 tttattattt tttctatatt tttatattgt agaatcattt ttaaactatt tttaaggagt
50221 tttggattgg cattcatggg taagatcgac ttttattttc cttcttgcaa gttccttgtc
50281 agattttaat atcagggtta tgctggcctc acaaaacaag ctgggaagca ttctctgttt
50341 ttctgctctt tgaaggtact tgtttaatac tggtgtgatt ttgtccttaa atgtttagaa
50401 gaattcacta ggaaagacat cgaggcctgc aattttctgt gtgaatatgt ttacaattat
50461 gcatgtaatc taacagatgt gggcagttca ggttttcctg ttctcatctg ttttggtaag
50521 tggcgattgg tttggaattt atttcattta aatttgtaaa attagtggca taattcgaaa
50581 tatcattatc actctaatgt gtataggatc atcgtaagat gctcttttgc attactgata
50641 ttgtttattc atgtctccta tttttttctt tcccagatca atcctaacta gggttttgtt
50701 aacttaaacg ttcttttcaa aaaccaactt gtgttttttt tccctaattt tggtaatttt
50761 tcatatgtat tttaatcatg aggaataata cctcttgtag aaagaagaat atacagaagt
50821 caaaatgaaa aataattaca atagtctgaa tttccaaaat tcgggataaa cacaattcct
50881 ccaaattttg tgtatattct ttcagattta taacacaaat gtatttatga agtatgtttt
50941 ctaaacacac acagatgaaa tatagaatta tactgaatgc tatttgatac atatgaccac
51001 tgtttcctca tttRtacatc ttcttactac ttccctgctt agattatttt aaaacatatt
51061 taatattgca tgaccttctt caaagattct acaaaatata tttataatca ataaggagtt
51121 tgtttttaaa tagaacttaa aatgagcata tctaacataa tttataagtt ctgcaatatc
51181 ataaaataat cataggctat ttgacttctg cttgtagtgt aaaaatatct ttttagaatt
51241 tattatttga attagaattc aaagtctaat aatacgttga attaatacat gttttatagt
51301 acaatactat ttattacctt tgaaatcatt tttattgaga aagtatttag ttgccataaa
51361 atgcacccaa ataaagtgca gaaattgatg agttctgata aatgtaaaca cctgtttaac
51421 cccacaaaga ggaatcagaa tgtatccatc acccaacagt tccttcatgc tcctttgtag
51481 acaatgctca tcacaccctg accctggaaa taatcagctt tctgtcactg tagagtattt
51541 ttactattct agaattttat ataaatgaaa tcatcttgtg ttcactttta tatctggcat
51601 ttttcattct acaaaatatt tttttaattg ttttatgttg ttgagtacat catcagttta
51661 tgtcttttat tgagtaattt cccattgtat agatatactg tttgtttttt ttttttaact
51721 ctgtcttatt tttgtcaatt attcattctt ttctaaaata tttcttaatt tttggcttta
51781 atttgcttta tttttccccc taatgtctta acttctatcc ttaactcatt tatcttctgc
51841 ctttcttctt ctgatatcca tgggctcaat attggtgact ttgctttcat ttgtgatatt
51901 gataatttgg gtcttttctt tccctttttt cccccataga tagcaaacta gaggtttatc
51961 aatcttagca aacttttgaa agaaccacct tttagtttgt tgattttctc gaatgttttc
52021 ctgtttccaa ttttattctt tgtgctctaa tttttaaaat ttctttcctt ctgcattctt
52081 taggcttcaa ttctaaattc tctaataacc taggatgaaa acttgcatta tttatttaga
52141 tctttgtttg ttttctaata tatgcattta atgctacaaa ttttcctcga acactgcttt
52201 tgctctatcc tgcgtatttt gatgttatat tttcattttc atacagattt aaacattcta
52261 gataatttca catgaaactt ctatttttaa cttgaatttt tttcagatgt ttaggaactt
52321 tctagttatt tttctgttat taatttatag tttaattcct ttatgacctg agagcataca
52381 ttgtatgatt tctattttta taaatttgca agagtgtgtt ttatgaccga taatacatgg
52441 tgaatgttcc atgtgagctt aagatgagtg tgtctgctgt tgttgggtga aatgttctca
52501 aaatgttaat taaatctagt tgaataatag tgatgttcag gtcttctata ttcttactgc
52561 tttcctgctt ccttgataca tcaattattc caactataat aatggacttc tctgttttta
52621 acttgccatt ctatcagtat ttgcctcatc taacgactct gttgttagtt gtctacacag 52681 ttaggattat tttaccatct tggaaaattg atcactttgt ctttaggaaa tgtttcttgc
52741 tatcccaagt aatcttcctt gttcttcagg tttctttgtc tgaaattaat gtagctcctt
52801 cggcttttat tttttattag tgttaacgtg tgatatatct ttcttcatcc atttactttt
52861 aatgtacgtt agtctatatt taatgtggat ttcttgtaga caacatagct gggcctactc
52921 tttctatata ctctgacaat ctctttaatt ggtatattta gattgctcac ttttcaagtg
52981 attattgata tatttgaatt aatatgtatc atgcttttaa ctgttttcta tttgttgcag
53041 ttgtttttaa ttttttgccc cattttaagt tccttatctg attttaattg aaaatttttt
53101 tatgattcta ttttatctgc tcttttactg tatcagtcat actttaaaaa ttgtcagtgg
53161 ctgccttaaa ctaaaccaaa gtctattttc aaatattaat aatactattc tacttattat
53221 atagtgcagg tcccttaaaa cagagtattc ctaacttctc ccttacgtac ctgacaacat
53281 tcatttgtaa tttaggtgaa tgtaatatta atttgcaata aaaattaaat tcatttaatt
53341 tatccatgtg ctataagcac ccaatgcatg attattattg taaatgtttg tcttttaact
53401 aatgatttca ttaactaaga ataagaaaaa taaatgatct tacttctttt atttcttctt
53461 taatgatctt cctttctcaa tgtagatcca gatttctgag ctatataact ttccttttgt
53521 ctgaataact tcttcaaaca tttcttatag ggaaggaatg ctctcgatgc attccctcag
53581 tttttgtttg cctgagagtc tttatttctc cttcactttg gaaggataat ttctctggat
53641 atagagttgt agttttattt ttacttcttt caatgcttta catattttac tcctctcttt
53701 gcttgcttgc ttgttttctg atgaaaagtc caatgtaagt tttatctttc tttctctatc
53761 agtaatatag ctacctttcg atgccctctg cttcttccaa aattttgttt ttgtctttgg
53821 tttactgtaa tttgcatctg atatgactca gaatagtttt tattttggtt tttaatcttc
53881 atgtttattc tctgagtttc ctggatctac agttcagtgt ctgtcattaa tattgaaaag
53941 ttattggcca ttattacttc aagtatttct ttgatctatt atcttttcct tctggtattc
54001 cacttacgca tatgttacaa cgtttataat tgcccacaat tcttgatact atcttatgct
54061 tttctttttt ctttttctat tacaggtttt tttctttttc tttttctatt acagcttttt
54121 ttttctttgt ctattacagc ttgagaaatt tgtatcttct tttcttttat atatatatat
54181 ttttattata ctttaagttc tagggtacat gtgcacaatc ttctgatctt ttgttggttg
54241 tattgaatct gttgttgggc ccatcaaagg cattcttcac ttctgttcca gcatttttaa
54301 tttgtagcat ttctctttga ttcttttgca gagttttcat ctctcgatta cattacccat
54361 ctgtttttgc atgttttgag ctttttccat tagacccctt agcatatYaa tcatagttgt
54421 tttaagccct tgtctgattt tcaacatctg tggcatattt gagtcttgtt ctgataattg
54481 ttttgtctct gcagagtgtg gggttttttt ttttcttact ttttgccatt ccttgtaata
54541 ttttgttgaa accaaaatgc gctatatctg atgacaatag aaactaagac aaataRgttg
54601 ttagtatgaa gatttacatt actctggcta agaaatgggt tacagtttag gtttgctata
54661 ggtactatag gtaccagatg cttccggttc atctaatgca cttatttcta ttcctccttt
54721 tgacttaaat tctcttcaga ggcggtcttt gttttttaag tctttcaact gttatccagt
54781 attattgcac tggactcctg ttgtgtggtg gttcgatgtg taagaggagc aatgttctgt
54841 aatattccaa ctcaatttaa gtgtttcagt gggttgttgt ctcagaactg tgaccttcac
54901 aagcatatct ctggtggtat agcttttttc cctcctgcca gctactgtct ttcctggcta
54961 ctaggtttcc aatctatttc tgtgacgctc tgactcctgt tgcttttttt tccttaggta
55021 agacaggaaa ggtacggagg ctggaatggg agaagtactg ccccccagtt gggagaggtt
55081 ctggcaaagt cttttcttca ggagaatagc cctttgttat gaagaaaacc ctgagcatac
55141 ttcacagtca ttccctttcc cacttcctga cagagccaga agggagtctt tttctaatct
55201 tcatagaatg catggatggg ttcttggagg taaagcccac agaaatgtgg agccctctaa
55261 gactgtggtc aggaacttct cactctcatg ctagtctaca ctcagtttcc agagattcac
55321 caaaattatc atagaagttt tcctgtcagt ttctggtgcc agtggctttt gttccaggtg
55381 gatggatctc agctctgact ctttggatgg tcccgtccct ctagatttca gcatggtggt
55441 gtgtcatgtg tactagcttg tgctgctata accaatacca tagactgggt gacttaaaca
55501 acagacattt attacttata gttcttgagg ttgaaaagtc cgagaacaag gtgctaccca
55561 attcacttct tggttagggt cctatttgtg gtttgcagat ggctatctct ctgctgtgtc
55621 tgcacctggt gaagaaaaag aagtctgagc tctcttcgta ttcttataag ggcactaatt
55681 tcctcatgaa ggccccacct catgacct ta tcaaaatttg aatacctccc aaagacctca
55741 tttccaaata cagtcacatt gtgggttagg gcttcaacat agaattttga gagggtgcaa
55801 tttattctat agcaccatga aagcacagtt ctctgatgag tctaagaaaa gtgattgatt
55861 tctagtttgt ttgtcttttt tcttgtggtg cagtgtagag cagtgtttca ctctgagatg
55921 ggtactgtgt gtgtgtgtat aaatattcta atatattcta acagaataat atgtatattc
55981 tgtagaatat atattagaat aatgtatatt ctgtagaata tatattagaa taatgtatat
56041 tctataggag ataaatatta atttcccttt aagaacagtt tttgctgcta ttttattatt
56101 ttttattgta cgtaggacac tacataagaa aaaaatgaat agacaatttt aggcctagaa
56161 ggctatcttt ctgcaaagtg taatttcatt cacttttaca ggcaaccaga agcactgaac
56221 ctctctgaca tcctcactat aattccccac agattggaaa gatgggaagt ttacctttaa
56281 tctccgtgcg gggctgtccc atctctggct ttccctttat cctaaaaagt agatcctcta
56341 aattcttaca aaaagcctat ggaagcctgt aaaatattct cttctttgag ggctctagaa
56401 ctaaaatttt gtccctaacc ccatgaaagc tgctcataaa accatgacca aaaacaacaa
56461 caacaacaac aacgaaacta cccagctatt gtttctcctc ttcagaaatc ctttagttat
56521 ccctaaagag aaagcctcaa atgctgggct cacctctttg ggttttcttc ttctagatct 56581 tggacattta atattttatt atatttttat ctcttcaact ttttttttat tccaaaagga
56641 gggttcagaa tttccagtct agcagtacca taatgtgaat ttttatagtt attgtccatc
56701 tcaataaaaa tttagtcttc cacaaaatcg tacatatcat atcctaatat aaatgtaagc
56761 tttatgactt gtccacatat ctctcataaa acaatt att gctgtgtttc aacaatagtt
56821 acagattaca gccaagtttg catctttcct gtSctttttc tcttctggct atttgatctg
56881 tcttgggaat tcaaaccctt ttatgcaaaa ggtactaaac agtatatttt ataacttgta
56941 tctccataga ttctaatata atgatttgca caaggggtct catcaagtta tcattaataa
57001 ttgtgttcct tcaaataaat attttaataa tattcagtat ttttggaagg tggtagagtt
57061 tgttaaataa aattccattc cctttaattt tgcaaattga gatgtattat acgtgcagct
57121 caaaacttaa cattctaatt tgattagtgg attctcattg ctatttcttt attataataa
57181 atgaatttta cattcataat caagactgaa tcaact ttgt aagatacagt cctgatgtct
57241 tgttcaacat atgtttaaaa gttactctca tctgggttta tgttagcaaa ttttccactt
57301 ttcagtagtt cttatttctg tttgctttta ttatatactt ttctagacta gataaccttt
57361 tgggaggcac atttagtaaa gatttatacc tgacat cata aaattaaaaa gtgatttcta
57421 tttgacagca tgttgctatg atttatttag catctgaatg tcagctgact atgtcaaaat
57481 gaattgtact tgaaaatagg tcatgtgtag gacacatgta ggtcacaaga attctcacaa
57541 caagggaggt tattaatgac aaggggattt tcatgfc ttcc ctgtttcttt gttgaacttc
57601 tactggtgct gctctttatt tggatggagc tggactgatt tctatataat tgcagagtct
57661 gctgtgcaac tatgtgtaac gggtcccatg tttctgattt ataacagtga cgttttagag
57721 cttcttacaa attgccatat gggcatctcc ctttat actt cttggctttt atacgtgagt
57781 tgctcaatta atatttgaaa aagaaattag tgctat tatg cctcttcata aactttagaa
57841 tcactttgga aatactcaaa atcctgtgag aaactt taat tcattaactc cataaatttt
57901 cttggttaaa atacattcct aaattgtcta tgaacacctc attgagtttg gaaatcacca
57961 agtctaaaag aaaagaaaaa tacaatgaag gctttt tggt ttttatcatg taagacatat
58021 aaagttcatt ttacttctag atattttatg tacttaatga tataacatat attctgtgtc
58081 tattaggagg ttactattta tatgcaagag tctta tgat tattcaatgt ttatcattta
58141 tttttgactc caataatttt gggaagatat aaagtt taat agaaaagttc tttgtctata
58201 aaagtcagct ggtggagctg agtcccagtt caacaataac ctaagttgca ttattctaaa
58261 atgtgtaaaa ggttttaaac ataaattatg aggaaaaatg aaaaaagctt cagataaaat
58321 attaaatttc ctctagggta agttgtttgc tttcatgttc tgttgaagtg atgccttttg
58381 atggcttagc taaattatgg gctttggagt cagaaaagcc tggaattaaa tccttgctct
58441 gccactttct agctgtgtga ctttaggcac ataacc cta taattttcat tttcctcagt
58501 tgtaaagtgg gtacaaaaat aactacttca cagagt tgat gcaaatatta aagctagcta
58561 atacatttct gctatgtctg atgctgagcc cctaac tttc atgttgaaaa catttaaatt
58621 ggtaacatag aacgcaatca ctagttgtta tggtcσaaat atttgtgtct ccccaaactt
58681 catatattga aatcttaacc ctcaacaaga tggtat tagg tggggccttt tgggagttga
58741 ttaggtcaag agtcctgtta tggaaatgta attagt ttcc ttataaaaga gacccaaagg
58801 agctcattca ccgttccacg atgtgagact acagct agaa agtggcattc tatgaaacat
58861 gaagtaggcc ttcaccagac accgaatctg ctggt cctt cattttggac tttccagcct
58921 ccagaactgt gaaaaataaa tttttgttgt ttataagata ctcagtttat gacttttgaa
58981 gtgagacctt ctaaaatatt ttttctctct gaaaag tgt gagataatat agggaacata
59041 aaagaatagg atttatacac aaaccagagg agtact ttaa gagtgaaaca aagatccaaa
59101 gcacaaaatt agcttggcat gcattcaaaa tgcaa ttc aggaccctcc ccacaaattt
59161 agtacacagg tgcaagattc gtttctaaag aaaca ctca agtaatgctg acatatacta
59221 aagttctgaa tctttaaagg aagacataaa tgtccc tgta ataaaattat tatttttgaa
59281 aaaagataaa gagatactta aatccatgca ttcctt tgtg aattgttatg gcaacaattc
59341 ttcatagcaa attgaggaaa gtttcctagg caaagg ata catttgaaac tcaatagcat
59401 gcactgaact tttcatttat aaagtaatat agcatcatat gcatcattca caaacattct
59461 gaaaatttcc atcaaatatt aaaatccaaa gcagaa ctt ggttatgtat gaaaaaattt
59521 caacaagtgg agcaaaaatt gcaaatttat tgatcagtta ataaatataa taaatagtaa
59581 ctgcatattt ttccaagtga cactggcatt agaaag ttat ttaaagtatc cagagtgcta
59641 ctaagtaatg cttttgcctg ctgtatggct atacac tctt cctatgtgtg tctccattat
59701 tttattatta taaaattaat acatgcccat taaaaaatct agatttgact ggaatgtgct
59761 gtaagtccca tatccccaac ctcacaattt tccttaccct ccataagaga taattgctaa
59821 aagttttgaa tatgacaatg atatttttat tatta ata aactgtatct tatatttatt
59881 cttaacgttt tcaaaattta aatagctcat aaattgatca agtgaaaagt gaaaggctgt
59941 catttgcaga tgtcttattc catttacctg ttggctgtct ctgccactgt gcatcttttc
60001 tcccagtccc ttaagacccc aaaatcattg aactcacatt aattttgaaa caaatgtgag
60061 atcttttgga gggtaattta attaatcatc cagctg ttca ctctgcaaga aattataatt
60121 agggattgtg ttagtctgcc agtggcacct aggaaa taga atcaaaagta taagaagatc
60181 taagatcctc aaccaaagct gcacattact ctaatt tgga aagcttgtaa agacataagc
60241 atacaggctg ggtgcggtgg ttcacgcctg taatcc taac accttgagag gccgaggcgg
60301 gcagatcatt tgaggtcagg agtttgagac cagcctggcc aacatggtaa aatcccatct
60361 ctagtaaaaa tgcagaaaaa aaattagcca gccatggtgt ctggggcccg taatcccagc
60421 tacttgggag gctgaggcag gagaattgct tgagcc cggg aggtggaggt tgcggtgagc 60481 tgagattgtg ccactgcact ccagcctggg tgacagagtg agactcggtc taaaaaaaca
60541 aaaacaaaaa caaaaagacg taagcttaca catacacaca cccaaagaga aagagagaac
60601 aaaatcaatg ctcaggctat gagcgctgag agttttaatg tgcagtctaa gttcgggaaa
60661 cattgcccta tatcagccat cctaaaagaa attgaaataa tcgatttttt aggtgaatca
60721 tcgggattgc catagaaatt gagactgtag tgctctagag gttgggtggg aataagattt
60781 ggttagtgca atatagaaaa cagctaacct ttcttaccaa acctcagtaa aaaattttga
60841 ccagtggaac agaatggaac cttctcaggg gtctggttat cagagtccaa atatccatgg
60901 aattaaacaa tgttctccta tttatgttct gggaaacact agtctggaaa tttgttctgc
60961 aaaacaacag cagcaacaat agcaaaaaca gaggggagca gttttctggc cttatatgtt
61021 tgagatgcgc taggtaagtg tccctgccat gggttgatac attgcaattt gcacattagc
61081 acatgacatg ctctgagagg ccctgtaatt gagacatccg ttgaactttt gttttgtttt
61141 taagctcagt ctttctcaaa catacacatt caacatatat tttattgaga accactttga
61201 gctgaacaat gttctaggtg ttacggatgg aacacaataa acctccctgc tttagtagag
61261 tttgttttct aggaggataa gataaacagg cagataatga tcaaataaga gaaatccctc
61321 ttaaaataaa gagaaataca gagaaaatag caagatattt atggggagtg tcaggtacac
61381 aggtacttta gagactgtga tcaaaaaggg cctgtcttgg gggtaatatt ttagtcaaag
61441 cttaaaagga caagagaggc agggcatgca aagatctggg gaaagaactt tcagagcaga
61501 atggactgct ggtgcgaatc cctgagagaa ctgaacctgg cttgttcaag gaggtccagt
61561 gtggatagag cataatggaa gtggttgcta aagactgtgt ttgaataagg agtttagatt
61621 ttgttctaag tggcaaagaa agtgttgggg atggcatagt ttaatttacc tctacaagtg
61681 ttactgtgtg ctcagagggg aagacattgg gggtgatggc aaagaacaaa ataataataa
61741 agaccaggaa gaggctgtca gggaagttct ggtgaggtga tgctttgttg aactgagtgg
61801 tcatattgaa ataaagagat gccccgattt tggatataat ttggagatgc Yatcacagct
61861 gtgcctgtgt tatgtgagct tgaacattta gtgtatgggg tactggtgga gtgggggcag
61921 aaggtagggg attgattgac aaggagaatc aaattaattt aactataaaa cacccaatct
61981 tttaaaaatg tactagaaaa tgttttggta aatga^Tagta agggaatatt tgtgaattag
62041 aaagaaaaac aggcagatga tcagataccc tggg attgg tgtttctaat gtatttatct
62101 ttgccttgtg cagtctacat gaggttgatc ttatttgttg acccagtcat aggcaaggga
62161 cttatcatga acctgcaaat gtagttgcat gtccccttat tatgaaagaa agaggtggag
62221 gagaggagaa ggaggaccat gacaaggaag gtgagaaata aaaatgaaat gtaaattatt
62281 gagaacaact tctgcttcat gctgacttct ccacctgtag tcttaacagt gtgctgtgtg
62341 gaagaaaaca aaagttgcat aaatgttggg ggctgcagta tgtgggtttt acaggtaagc
62401 tacctattat gtcgatgcat cctgatttta tggaagaaac atagctcctg gccctaccat
62461 Rtaatggttg caatggttgc aaacactgga gggatttttt tttctttcct ttctgacctc
62521 taatttcctt gtctgcaatt tgactgtgct agcttagcat caattcccaa gatttctcta
62581 gctttcaaat tctaaagtcc gtaagtttaa ttacaggtct ttccaaatta ttattgcttc
62641 caatttccct tcacaatttg aatgtgtgta tctggcattg tgctgctgag gtttaacaac
62701 ctgttagctg agtgtagctc caacttgaat gttgcgtggt acttttcttt atgttaatga
62761 gtaagatgag aaagtgaaag aaccaaaaga catcatagct taattcattc atcaatgatg
62821 taagcaactt ctttgttgac tcgaatgatt gtttttcaac ccttggagaa tattttctca
62881 atttttttgg tgctattcac aatgttaagt gctacagaca tggcacattt ttacgtttaa
62941 tctacacttt acagaagcaa tttttgttac aggtatcgtg gttgaaaact agtttaatgg
63001 ggtggtagaa tttaaactct cttaagaaaa aagaaaagtt gaagcgacag taatttctct
63061 ggatgcagag acatcatgac ataactgtta atgtgatttt cttatagaag gtagcaccat
63121 tcatagtaaa atgcagatca cacattgcta atagacatta taggtgacaa gctgaaatgg
63181 atgttctcca gatacattga tgtgcttctt tcccttttct tttagggttt ttcaggaaat
63241 gcaaatgcag acagtgttgt gtactataga ctccagcctt ctatcaaagc cagatttctg
63301 cgcttcatcc ctttggaatg gaaccccaag ggcagaattg gaatgcgaat cgaagtgttc
63361 ggatgtgcat acagtaagtg tttgtttatc caatacactg acatagatat caaaagagat
63421 gttttaaaag ccaaactaca aactgaaatg gactttttag ctacataaag aggtataaaa
63481 aataggaata atttttgtgg aaagcttttt tgtgcatgcc tgtacatgcc aatattgact
63541 ttcatgttca actttaacat tttaattcag agatggaagc acttgataga tggatagata
63601 catatttact gatacatggg aatgtatttc ttcaaataga atattattga ctatgttgta
63661 actttcaaat attagaagtt tccttcatga gttatatttg atgatatttc atttaggtat
63721 cctgagtcta ataaaaggga cagtgttcca tttagtttaa ccgtcatgtt atgaaaccaa
63781 aaaatatttt ttctttagcc taaaaacaat atcatgcaat tσacctttaa atgtgctatg
63841 ctgtcagtat aaattaatag aaaaagagaa gacttctgcc tgaatataac atgtgtttaa
63901 aatactttca cataaaaaag atagaaacca cagat ttcac ttagtctcct cttaatgaag
63961 cattttatta tatatatttt ttgtgaggaa gggacctaag agttattgat agtgcacctc
64021 aagccacatt atcctgttag atacactttt attatagaac agtgggttag ttaatatgat
64081 ttacaattag cagactaaca gtgtgaggtt tgaagagatt cactaatttg ctcagagcct
64141 cacatatgaa ataatctgga agagaaccca ggactgctca attcacgaca tcgttttttt
64201 tttttctcta gtaaacattt atttttagct actaaagctt ttttcataca tacgctgtca
64261 ctttgtgatg taagccaagt taagttctga ttcac tttct ttacataaaa gaaaagcagg
64321 tgataaagag atcaagtgac ttgttgaagt tgtctaaact ctatccgaca gagagatcac 64381 attgcatggt ttgcgtgggt actctcctgt attttgtgat gttttcagtg tccatctcta
64441 ccatcaaaca tatttgacag acctgattcc tccagggcct acagaa aat actaataaaa
64501 gtattaatat aatattaata gcaataatag cagtaacact aatagt ata ttaatagcat
64561 tcctttctat aactgtagaa atagcaccgt ttccttagtg cttattatat gcactattcc
64621 aagcagttta cgattcctca aaatagcccc gataaatatt actgggtaac tactccattt
64681 acctcttttg aaaatgagaa agctaaagct tagagaggtt gacttgctca agccacacag
64741 aaaggaagtg gcagagctgg gtttgcagcc aagtttgcca aactcc gaa agcaagctta
64801 tattgacatt tcctctagtt gttgaataac agagatgagt cagtggccaa ctaacctctc
64861 actatctgtc cgccttaatt gcaggctttc gtggcttcaa caatcc gct tagctacacc
64921 atgttagttc ctcacgtcac aattagtata cctgaataaa atcacgcatt aaaaaaatcc
64981 tacccccaat tatgatcctg caaactagaa gttggacagt agtcttattt gtctttggat
65041 cgtagagctt agcaaagctc atgccacatg atggacaact agtaaaacca atttcaaagt
65101 gcttcctgtt tacagttata ttctccactt attcagaaca tccacc tgc aaaatacttg
65161 tctatcacag tataaaaata gctaacagtt attgtgcatg tatttt tgt agacattcta
65221 ctaataattt aatcctcaaa accacccatt tattagagag aaaactgggt cttagaaaca
65281 ttaagcaatt tgttcagtac cacaccctta gtatgcatta aacctaggat ataaactcaa
65341 tattaacaaa tttaacatta agagcaacag tttagtggga ctgtttatgc tgttttgctg
65401 gctctaaagc accaggtata atgtccacat ggtggtgata gctaaggtac aggttctttt
65461 gagttatctg ctgctctgtg gctaatgata actcaaacct ccccct cacc tgtcttgatc
65521 tgcagctctc tggaatgttc tttttgttgc aacttcattt gctata ttg gggtgagcat
65581 actgtccatg tatttggtca atattctttt cacattgacc catggt tgaa gtagtagtac
65641 tggaagccag caggatttta aactcaaact taaacacata tagtga ata gtgtggcagg
65701 agttaatgac aaatgatggt tgtgtaactt taaaccatta ttaaaggaga aaaagtaata
65761 aacttaatgg ataaacattc ttgtagataa tcagaaaata accaaagaat gggttgggca
65821 tgagtacctt atgggaatgt atttgatcaa attggctttt atacct caat tacaccatag
65881 tcatgctcac attttccacc tgttcatagc attggcattg caatatattt attaaaatgt
65941 gatattatat agccatcatt tattaaagtt aatatgtgtc agagac tgta aagaataagc
66001 atcttctgat ttgttcctag taatgtaggg aagcaggcac atgaa ttg ccatttcatg
66061 caggagtcag aggagaaaag cagaattatc tactgaataa gacat cagc ttgctctggg
66121 tggcatggca aagaaatagc taggactact ggctttccct gccctcagaa ggaagggctg
66181 tagttgctat catcacaagt atcctgttgc aagagtttgt ctgcaactcc cttaagtagc
66241 acagacccaa gatcagattg gattttcccc agacacaaaa gactgt tctc ccgaaatccc
66301 tattaaaagg aaaagtggtg ttggggagtg ggtagggttt ctttac tgaa tcacagccac
66361 aggacattca tccatgccca acaaagtagg tttcccctga gcttgaggaa ggcctgaagg
66421 attgcatgca actggccatc ctcccctgtc tgtgcctcct catctgcacc aaattaacgt
66481 gactcaggtg cgcttcgcct gagccattca ctcaagtgta gcacacctcg cagactgctt
66541 catctcttct gacatagaag aaggtgaact taagagaaat tggtaacttc tgcagaacta
66601 cacaacccgt gttagatcta ggatttaaaa tcagctgtct cattt ccta agccagtgcc
66661 cttgataact atgtgaatca tacatgtatt gagcctttaa ccatttattg gtacttgcca
66721 aaaagaacta ggtatggggt atagggagat attctaaagt cataaa att ttcttaataa
66781 agacaggcat gtgcaatgtt agaaaaatta tatgaactaa gtataaaata ttgtagaagg
66841 agtatagggt gtgagggata aagtgattga taaattgtgg ttagta aag aaagtttata
66901 gcagtagatt ttgaaacaaa gttgcagata ttttcacatg ggagac tgaa aggatggtcc
66961 aaataggaaa agtgctgtac cccagtcaag cacaggaaag aggattgctg gaatgattat
67021 ttgagtacag tcattcagac tgaaattagg gctatgggtt agaggg tgaa atctggaggc
67081 agcaactcat tagaaggctt tcactcttgt ttggacaagt gatggt gaa ccccaagcta
67141 gaggaacagc aatcagtaaa gggggaggaa gggcaaggcg cggtggctca tgcctgtaat
67201 tccaggactt tggaaggtgg aggtgggggg ttacctgagg tcaggagttc gagaccagcc
67261 tggccaacat ggcaaaaccc tgtctctact taaaatacaa aaattagccg ggcgtggcag
67321 cgcacgcctg taatcctagc tacttgggag gctgagacag gagaat cact tgaacccagg
67381 aagtggaggt tgcagtgaac cgaaatcatc ccactgcact tcagcc tggg cagcagagtg
67441 agactctgtc tcaaaagtaa agggggaggt aagcagattc aaaat tct taggatattg
67501 aatcaagata tcttggtcat tgtatgtgag ggaacactga gttatcaaat ttgctttttt
67561 tctttcctcc gttgatcctt tttttttcct tcaaatttga acaactgtct ggaaggggct
67621 gtcatttact aagatgggaa atgagacaat aaatagattg tggaaggaaa caagagataa
67681 ttaatcctgt ttttgacaca ttgagttcaa gggcctttga tatatggaag attggaactc
67741 caagccctct gagttgaaga cgtagaatta aaacctatat aaatat catt attgttagta
67801 aatcataaag tattctactt attgtactac agttaataac aaatgcgtga agtgctatgt
67861 ttgatcgact actcatgtct tgaaaaatgg gaatgcattt ccgtca aat aaaagcagct
67921 cctttgtact attttttagg tggaataaat atttttatgc caggct cccc ttgtgcctaa
67981 tacatgtttg ctgaagtcat agatgcaagc ctatcctgtg attatt acag gaaaatggct
68041 attgtgaaaa ccacacataa attgccgttt accccaacaa gttagggcag taacttgtta
68101 tgaaggaaca tcaagtgaat ggaaaatcca tatcaaagag catgtt ctac ttttatgtca
68161 gtaaacttga agttgtttcc tgagtaatga gagaagtaga ggctaaattt tatgggatca
68221 aagagaaact ataaatttcc aatatcttgg ccatagSagc agtgat cctg tttgcagatc 68281 tggagaagaa atgtatagaa gtaaattact ggtgggagaa agaaagaaaa agaaaagaaa
68341 atgtttgatg ctacagaaac aatactacat gtctgaaaga gaagtaaaca atggtgaaca
68401 aaggaaaata aatgggtgaa agtgaatata tctgcaatgt ccttaggaag cagcaattaa
68461 accataggag ataatgttct ttaattgtgg atgaattgct gaggcagttg tccttagtgt
68521 aaattctaat ttccttttct ctagttactg tataaacatc ctcattttgc agcctatgat
68581 catctcttcc tcatccccaa cagaataaga acatccaact gtcaagccat actcaactaa
68641 tttgtttctt tggctagcca tgattttatg atttttctag ccttagggtt tctgcatgat
68701 gcctagggca atcaccacgt acccaccagc cttcatttct ctatttggat aactctctta
68761 ctcattcttc ttttctcagc atagaaatct ctgcttctga caacttctct aataccccac
68821 attcaaatct gggaatgttt ccacccactt gtagaacagc ttttcttctc ccaatcatga
68881 catgcccacg ttatactggg ttgcaaccag acattctttt tttgttatta gtcttctgga
68941 taaagactaa taacaacaat gaagaatgaa tgaatggggg caagcttagt aagcctcagg
69001 aatgctttct ccatcattct agtgttcaac ttgttaaaga tcaggaataa aggttagcct
69061 accaggagaa ctgagggaga agattggaca tgatgagcaa atgtacagat gtgttaaacc
69121 attgtgttta attgcttcaa tgcagacagt tgaagagaaa attatggatc atatttaata
69181 aattaaacat caatcatttt aaaacatatt aacttgcaca taataggaat gtatacttta
69241 ttatttaaaa aaattccaat ttttttacat aataaactat aaagttggaa ttataaccat
69301 cagcagattt aagtttagaa aacatataaa gaggacaatt taaaaagtac tgtaaaagca
69361 cagacattta cctgggtgag gaaaacaaaa cattgaaaga cagctagata atagtctctg
69421 tctattcagg atgctaatct ctcataccac ctgtctggtt agggggaaga atgaaaagca
69481 ataaattggt tagatttatt aaaatgatag ttataattga gttcaatacc tatttattga
69541 gcaactccca catgctaact gctaaaagct ggagtaaggt gaattagata gttcttacac
69601 tcagattatc tatcagctaa tatagtagct gagaaatact gttttatgtc aaagtttgaa
69661 aagaagatag actctgattg gcctaaaatc aaagagtata aattctctaa ttctttgcaa
69721 aatttataat tttaagtttg atgacaagtg gagtgtatta gggttctcta gaaagacaga
69781 actaatatat atRtgtgtgt gtgtgttctg tatatatatg cacacacaca tatatagaaa
69841 tttatatata caaagggata tatatctaat aagatacatt tgtataatt aaatatatat
69901 atttataaat atatatacta gaaatattga aatatcgaat atatataaag gggagtttat
69961 taagtattat taagtagttt actgagtatt aagtattatc gttaagtagt tattaaggtc
70021 tctccaaata agattatgac acaaagccac aaagctggag agtttgatat acccctgagg
70081 taggacagta aaggtatatt gctggcattg ccagctgaaa gcaaattgt t tctggtgagc
70141 cttatggaca ggaatggaga aaaaggcatt tgccaagtca atggctgcac accaggtacc
70201 aggagatgtg ttaattggag caggcaatga aaccacatct agtacaacag ctgcaattgc
70261 aatcaccact tgattaagct tacaataatc cgctgtcatt ttccaagat c catctgtctt
70321 ctgcagaggc caaatgggag agttgaatgg ggatgtggtg ggaatcacca cccctgcatc
70381 tttcaagtct ttgatgttgg cactaatctc tgcagcccct ccagggatgt gatattgttt
70441 ttcatttact atttttcttg gtagaggcag ctctaagggc ttccatttgg cctttcccac
70501 cataatagcc ctcaacctcc cagccaggaa gccaatgtgg aggttccgc c agctgctaag
70561 tatgtctgtg ccaattatgc atcctggcac tggggaaatg accacaggat gagtctgggg
70621 acgcactgga cctactataa gtcacacttg agctagaact ccattaatca cctgacctcc
70681 ataagcccct actttaactg gagcaccaca atgatgtttt aggtcccct aaatcagcgt
70741 caactcagag acagtgtcca gtggtccctg aagtgcctga ttattttcc t ttccccagtg
70801 cacagttacc ctggtaaaag gctgaatgtc tcctcgggga aggataggag aaagattaac
70861 agcatacatt gtcagtaggg tagtagggtc cttcctcaaa gggacctggc ctccccttca
70921 ttcaaggggt tctgggtctg taaactggct caagtctgga agttgactga agggctgtga
70981 ttctctgttt ttataattca aatgagtctt ttgtcaattc aacctagaag ttttctactt
71041 atataaatta agcaggagtg cagtaggctt cctatcagtt ttacttctag gaacactgtg
71101 attaattagc caatgccaga gctctataca agtcagacta ttgtgattgc tgttttgcct
71161 ctgctgtcca ttacagtagc tacgcctgcc ttgcctttga tgtttgagtg ccaccacttg
71221 gttcctgcca cctcaggatc cagttattcc cattttattt aaattttgt c gttgagtgac
71281 tgtggttccc actgttagat ctgacataca gggaagagca attgtagggrc tcttcaaaga
71341 tgcagatgct gccctcacaa atctgttttg caaggtgttg gtcaagggta tatcttctgg
71401 accctcccag ctgggatgag taggtctaaa gtgactaatc tactccacca tccccatctc
71461 cctaagcctt tggattcctt tctctacatt aacccaaggg acatcaggct tccagctcgc
71521 tcacagtggg ccatctttta atccttattt cagctaacta agcaaataa-g ctgttagaac
71581 cttttttaaa actccctaag ctgcaacgtt aaatgcagaa tacctact a gtgggctgaa
71641 atcaataaat tcagcctgat ctaattctat gtttcttcca ccattatccc acacccttaa
71701 tatccattcc catccctgtt ctccagattt ctcttcatat aaattagaaa actcaagaag
71761 ttcttttcaa gtgtagtgca cctcctcatg ggtcacactc tgaatgtca-c ctctaggggc
71821 ccgccaggac tttagtctag ttataggtat agaacaaaca ggggtgttgg ggttggttcc
71881 tcaggagaat caacattatc tctcctggca actgcctcag gggaggccat cactgttgtc
71941 tcaggcagcg cagggtttat ctcctcagac aaaggtggaa agaatgatgg cagtgtgggt
72001 cagggagggg atgatgccgc tactggggat gggaaagctg tttcttctgrg caagaaaggt
72061 tcatcagagt ttacaaggtc agtgtcccca gcttcatcag ggtcctcccg cacatcccca
72121 ttccaagttg caaggttcca ttcttttcca atcaatgcct tcattttaac agtagacatg 72181 gcaaggctgt gcatccacct ttccttgcag ttcagccact cacatgataa gagct catgt
72241 ctgattttcc acaatttcag ctttctctaa aggagataag actctgactc gggtcagtct
72301 tagaagattt gagacccact atctgcttct gaagccagga gacagaatcc ctgagttcat
72361 cattttcttt catcactttg tccagtgaac tgaggagcaa ccaaccagct tcattatgtt
72421 ccttggttct ccacatatgg tcaaaggtat tatgtataga gtcactaaac tcctt acctc
72481 tcacaagtgg taaatcagga gtgtccaatg cattaatttt gcctaactct ctaaacagtt
72541 catgccaagg actatcagtg ttctccatac tattagaagt agagtcctta gcatt tttgg
72601 gtctaatcat attaagcagc caactccaga aaccccaaaa cagctaaaga actccatcct
72661 taatattctg ttcctgtaga accactcctg gtaccaaaat ctgtattagt cagtattaat
72721 ctgactaata cagaatatct atctatctat ctatctatct gtctatctag gagtt tatta
72781 aggagtatta attcacatga tcacaaggtc ctacaatagg ccatctgcaa gctgaggagc
72841 aaggaagcta gtccacgttt caaagctgaa gaacttggag tctgatgttt gagggcagga
72901 agcatccagc atgggaggaa gatgtaggcg gggaggctaa gccagtccag cgttttcgtg
72961 tttttctgcc tgctttatat ttgctggcag ctgattagtt ggtgcccacc cagat taagg
73021 gtgggtctgc cttccccagc ccactgactg aaatgttaat ctcctttggc aacaccctca
73081 cagacacacc caggatcaat actttgcata cttcagtcca atcaagttga gactσagtat
73141 taatcattac atggagttat attaaaatta aaataagatt agctattaag atac agaaa
73201 ataaggaaac tatgaaaacc tatcagggtc atggcaaaag aattcagcat cagttgaaga
73261 ggctctcact gaccaaaagt gaaaatgttt tagtatcaaa aaggatagta actgσtaagt
73321 tttgcaacaa attaagtatg tttgaatgaa tgggttcatg ataataataa ttgaaaaagc
73381 cccattgatc acctatgaga gacataaaga cccaactcct tattttgaaa actaatgaac
73441 gaatagagga aacacgaacc atatcttaat tttcctatgt aacttgaacc tccaggtaac
73501 cagatagaag agaggagtat ctctttaatt aaatatttta ggtaataaat aaaaatgaat
73561 aatagaatta gaaaatgtct atttggcagc actaaataaa tgactggttc aagctaacta
73621 tgacggttca caacaaggga gaagatcagt ttttcagtat cagtcatggc gttgtagctt
73681 ttattggact aagctgctgt ccataaaatt ataagtgtta aataaaatat attttaaaag
73741 cctgcttcag agttctgaag tttaaggtat taataaaatg aaagaaactg gagcagaatt
73801 gattcttgga ataagggaag taaactttgg gaaatccaca tttatcttgc ttttaccaaa
73861 ggaccagcag aaaatagcta gattttacta ggaagtgggg acagaggtca gatttcaagt
73921 tgccagagag gctagaaatt gagtagggaa tatttagaag aagatcagag agcaaKggtc
73981 cgtgctcctg cagacacaWt tccctcagat ccttggccaa ttcttgtaac tcacatgctc
74041 aaggtgaaat gcYaagcagc cctagagaaa gcacgagaaa gaggtttaaa agtctaaaga
74101 tttcagtatc tacgtagggc tggaagggga ccacctttgg agttcaagtc ctgccaattt
74161 agaggaattt gttaaacacc ttggagtttt actgaaatgc cacaaggtaa tctgtcacag
74221 gaatagagat gttttttaaa aagggaagaa agaaatccca caagagtatt gccttgggag
74281 taaagactgt acctgaggac atattgttat atcctagagc taaggacaaa accaaaatag
74341 acttatccaa caaaacttga aactaaggct tcacagggtc taggtgatca gccagtaatt
74401 cacctccctg tggaccactg ccatttactt cccgccagtg ccatccagct cgccactgtc
74461 tctcctacac tcctaacagg cctcatccct cccataccca cactctccct tttcccactt
74521 cctccttctt tcctggccgc tgctgacaca tagggttacc tactcagctt aaatagcact
74581 tccttagaga tattgtttct gaacaccaaa caaatttaaa tctccgtgtt caaaactctc
74641 ctgtaaccct gtcctttcat tccatgcttt ggaacttgta catttgtctg tacatgtgta
74701 catttgtaca attacaactt gtaaatatgt acaattacat atctttacta ctttactata
74761 tttttaaata gaccaattgt aattgtacat atttaccaac ttgtaaatgt acatatttac
74821 attataatgt gtaatatgtc tgtacacaca ggaggatttg cctgctctct tccttcggga
74881 tggagcatcc ttgaggccag gtgtgttcac tgtagcaaca gcagctccca ccgtagcact
74941 tgacacagca ttcaataact attggttaaa tggctgaatt aaaaaaaatc tgattatcca
75001 tgatgtaaat tgtatcataa atacataaaa atcacaaatg tattacattc atacagcagt
75061 agttgatcaa aagagagata actttgagat aaacgtgatt tcaagtgttg ttattattaa
75121 aatcataaca gtatacaaaa taatgttgag gcattttgat atttccattt gatccctcta
75181 gcatctttgt gtagtatgag aggctggaat ttttcagtac atagccaaat aaggaaactg
75241 agaatcaaca tttaggtgac ttctgtgaca ttgcaaaagt tgcaaatgaa tattagagcc
75301 aaaaatgcaa cttaYatcct ccggtgatgc attcaagtgt ccttgacata gtggatatta
75361 ctaatttcaa atctgtttaa aagattaatt tacattgaca aaaattaagt gagaatgatc
75421 atgttttttc ccataacctg ctggtgtgtt gttactgacc ttaacttggt ctatttaaaa
75481 agataataag ggcacctttt ccctgtggtt atatatagca cttgatctct gtgccttctt
75541 cctttttatt gtattaattt tagttgtttt aaacttaaga gtccttaaat cattctgtgt
75601 tctgttatgc taccatgcaa aaatagtata atctatttcc tgttgatttc ttgagtactt
75661 ggtctctctt ctccattgct ttaaaaaacc agttcagtaa tgcaggtctc aagtgcctat
75721 ctatcatgMt gctactttaa tatttcacta tataatagtt aaacagcgac tcagtctgat
75781 ttgtgtttct tagaagtcaa aattggacct ctgtttgttt agtaattcat gggcaataac
75841 tttcaaataa ataaacagta tgatcagtgt ttaaggctga cttcattttt aactaagaag
75901 agtttggtct ataccccttt ccagttgatg aaatagctat atattttttt tctctgatct
75961 ttgacaggaa cattctagtt ctatttacat tttggggaga ttcctaaaga attaataaaa
76021 gactctagtg tctttttcaa tcactctttc atgaccttca aatacagtta attttctatt 76081 atttaaaaat tgattttcta atttacacat tttctattcc aatttttctc ttttaagttt
76141 ttagtcatct gacctcagca aaaattccat gattcatagt ttcactcaca gaatcaattt
76201 atcccgaaaa catcttcaag ggacaaatct ctaccacctc cacaattatc ggcaagtacc
76261 acccacagta taaataaata aaacattcat ttccatggta caattcattt ccaggtacaa
76321 ttcaatatgc aatggggtta tttattttca gagaataggt ttatggaacc tacttgttct
76381 tcctatcaaa caaccctcat gctgccatct gcctcagaat catttaggga cctgtattcc
76441 tgttccaggt tagaattcca gagatYctaa tttggtgaac attaggccaa gcccaggaag
76501 tagaatgttg aatgtttatg gagatcccaa gggattcttt tccattggtt ccaatataac
76561 tggaccatag agctcagttc atggtcttga atatttttct tagtaattca cttgggggtg
76621 aggaggacat tgctttttca agtgacaacc cctcaaaatt tgagaagcct caaacttctg
76681 gagaagggct aggatgcagg ggtggggaga agataccagg aaaactggaa tatattgcca
76741 tgaggggtgt gtgtgtatgt gaaatatgca gtggtagaaa aagtttgctg ctcaagaagg
76801 taaagcgttt ttacaattta gttgagaccc ttcttagagg ctacagcgga tcaactccct
76861 ctcctgcatg tcttagaaat cattcaatac ccagccgtga tacaaaagcg gaactctgaa
76921 gacaggcatg aataattgca tctcagggtt gtgtgtcttc cccaattgac tataagctct
76981 ttcaaaaaaa caaaaagtgt tctttgtttt tatgcatcac tgtgtcttcc acggtattca
77041 cagaaagctc tccataaata catgctgcag gaaaaaaggc agaagacaca tttcaagaat
77101 actacatctg acacaactcc ctgaaagata tttgaatatt ttctattgca aagctcttaa
77161 ttccatggca gattgtattt ctgaattgtg taaataaagc aagctatacc tacggRMaca
77221 gggagaattg atatgagagt agggcgtaca atctttttga gtctcttctt tcctcgattc
77281 ttgctgtaaa tgtgaagatt tgagatggag gtattcactg agggggaatc aggtcaccag
77341 caattgctgt ggtaagtcag cttgggtagg agctgacaga cacagaaaaa gccacagaac
77401 ccacagatgg cttgaaatca tccttgctgc ataacctggc aatgacattg ataattaagg
77461 gtttcttatg tacttcagca attcattatt atttaaagag tcacaaatac accaaatgta
77521 cttattaaac tattttttgc tatgcacctt ttcctgccca atattctaac aataaatcct
77581 agtgctagca ttagtagtta atattcattt attgctaatt gtgtgtcagc ttctaaaaac
77641 taggcagata agcatgcata caacaatcct aagaagacta tactattatt ctcattttac
77701 aaatgagaca acagggacaa agaggttaag taactcactg tgataaagag gataatacct
77761 ccctaatatc ttagtccctg aaacctgtaa atatgttgtg ttaccatggc aaaagcgctt
77821 tgcagatgtc attaacttag ggatcttaca atggggagat tattttggtt tatccaggcg
77881 gacctgatgt aatcacaagg gtccttataa aagggaagta ggaggcaggg agggagagag
77941 ggaaagaaag gaagatttga agatgctgtg acactggtca catgaaggaa gaggccacga
78001 gccaagtggt ctctaaaagg tagaaaagac aaagaaatga attatttttt agagacttta
78061 gaaggaaaaa gctcctgcca acaccttgat tttaggactt ctgaattcca gaattgtaag
78121 ataataaatt tgtgatatat taagagacta tgtttgtggt tatttgtttt acaacaataa
78181 taggaagctg tctgaatcct tttatgttgc tataacagaa tatctgaggc tgggtaattt
78241 attaaaaata gaggtttatt tagcttatgg ttctgcaggc tgggaagttc aagaagcatg
78301 gtgctaacat ctgctgggct tctggtgagg gcttttgcag ggtcaaaaca gtggagaagg
78361 tcaaaaggga tgtggaaaag tgcaaaaagg caaaacctga ggggtgtctt gctttatagc
78421 aacacactct tgcaagaaca aatccattct catgagaact aatcagtctc atgagagaag
78481 ggattcactc actaccctga gaacagccac aaaccattca taagggatct gcctcatggt
78541 tcaaaccctt tccactgggc cacaactccc agcactgcca cactggggaa caaatttcaa
78601 tatgagtttt ggtggagaca aaccacatcc ataccatggc agaaaataat atacttgctc
78661 aagtttgagt gagtattcaa accagcacag actagttgcc ttaactacta tgccaacatg
78721 aaatatatat tattagaaat ggctgaaaag ggggctagac taaaaagcgg ggaatttgtc
78781 agaacaattt gcaactgtgg tcagagaact agagttcata ccctgcccat agtgagccag
78841 tgtatgacag agccacatta ttaatctcga taataaccca atcatttaaa atatagaatg
78901 taaaatatgt ataatatata cttaaatata taaaacctca gttaataagc atactaatga
78961 acaaattcac agttagaaaa ataattctta ttcttccttt cagttaagca aaaagtctcc
79021 tcttacatct ttagactgta ggccttttac tgttacaaat tttgttaact tcagatttca
79081 catttttcct atggtcaatt ttataatact tctacttttc ctatttatac aattcaacta
79141 tgtacaaaag attgtcttcc cagcctgggc aacatggaga aactccattt ctgccaaaaa
79201 tacaaaaaat tagctggaca tggtggcaaa ttcctgtaSt ctcaactact tggaaggctg
79261 aggctgaggt tggaggttca cttgagcctc ggaggtcagg gctgcagtga gctgagatta
79321 tgccattgca ctccagccta ggtgacagag ggagaccctg tccaaaaaaa atattttccc
79381 aaaggtattt acaaaagata ggagtaagta tgatattgac tgttaattta aatattaatt
79441 ttattttgga tgcttaattt agtgtttcta aaataaatat tgatttgtac taattttagc
79501 aattctattt actcatatct ttcatagatt agtacaatac aaagacatat tgctatgaat
79561 caccctgaaa ttttttattt ttgtatctgt ttgcattgct gttgcttttt taagagctca
79621 aatatctgag aatctttgtg gaatagtgaa aataaattct ggtgatggct aagatttgat
79681 atgttgcttt cttggtcatt gatgtgaaat ccaaacgtat gttttcagtt cgcaatgtta
79741 aagtaaattt tcaaaacata aaaacataac ttccattcaa atacagaata tacatgtatc
79801 aaagaagtat ttgattcatt aatgaaggaa tcagaaggat ggtaaaacta gtttcaaaga
79861 aaattcaaga gattgagtgt atatatagga atccaggaaa gcatgttaga ataatattac
79921 taggtagata cgcaagaagt taatattcaa caggacaata aacccataac ctttggagat 79981 atagtttcta ccagacagaa gcaatttgca tctctactga gcaaaaatct a agattatg
80041 tttaacttta tagaatctgg ccttaattat tattcattca gtaataaata gt aaaatcag
80101 aatttattaa ttcacctaga attaaataat ctttacctgt tagaagatgt tc tacaatga
80161 cattgagaag atgtgaagtt atttctttgc tttatttatt tccacttttt tt tctaattt
80221 ttcttaacag tggtaagatc actttcaaga gaatctatac tcctgtctct gt caccagca
80281 tttttggaca gctgagtact gtccaaaata tatagaattg aaatgctcct tctctctctc
80341 aaaagattaa ttttttcagg tttttatatg attaacttta tgccacataa ct cagaattt
80401 tgtaattgtt taagatgatt tttaaagtat atcaaatggg tgcaaataac tt tttataaa
80461 aattgcttat aaaaagtgac ctacaatgag tgttatatct aaaataatac tgttaaaaat
80521 catccagaat tttttttcat ttcctgagag tctgtttcta tatattaaat gtgtatcctt
80581 tgaagttttc ctgtactgat aatgtactcg cattgtgaat tatactgaac tttttttctc
80641 tgaagggtat tgtttacctg catgggaaat ctgtgatgcg actgtagcca gt ttgttgat
80701 ttccgtcttt ctgtactttg ttcctttcag gtcccctttt tcaaggtgag cσaacctcac
80761 tcctactctg agtactaaat tatttcctgt cactgtagtt tctcagcaat cctcagagct
80821 ctctYttatg acagtgaatg ggacagtgct gggaaaatgt ctaggcctct tgraaattaag
80881 tgttccaaga gtaatcctag tttatgggga caagttatag gacttgaaga ctgtagaggg
80941 tggcaagatt actgattaag atctcccttt gcctcctgtt tctagacctg agaactgaga
81001 gagcccttta tcaactacct taagtgactc cagccttctg ttactcttga tcagaatgcS
81061 tgttacaacc tgtaatgctt ttatgaactt agttgtKtac ttgctaaata ttgtctgtct
81121 tcactaaatg gaaacaccat gaggacaggg gccatattta tgttgaattt tttttaaatc
81181 ccagaatctg gcacactgat tcaaacgtga tgggtcaaat aaagttttat tgaatgaatt
81241 catagaattg cattgtcgtg tacctgtgaa gcaaggagac agtaagaatg acagaaaatg
81301 acaagtggcc ttggtttaag agtatgcaat tgctttaggc attaatggtt ttatatgttt
81361 ttctctatgc cattttgctg attgaaatat tccaggcaca aaagctttag gtgccacaga
81421 agataMatat catcattata atgtaataat aacagcagcg aaaaagaaaa aaaaagtact
81481 agtagctaaa gtaacacaag ctaaaccttt aatgggaaaa attctcttgg tagctaattt
81541 caaaaatagt ctttacctaa aatgaaatca ttactgtcat agttgccttt aagtgataca
81601 ttaactcgga gataactgca ttgctccaaa tgtgtcagca tttaaagtct gtcttactgg
81661 aatttttctt aatttattgt aatctaataa tcataggatg cattatttgt atttgacaca
81721 gttgtatttt tcccatgcgc attcattcag ctatgtaacg aggaaggatt gttaggctaa
81781 cattattctt tctacagaat gcagtattta ttcatgtgca cttggtgaat gaattctcta
81841 taagcacatt agcaaaatgt gaaaaaaata aaacctctga gtcttcaaaa gatggctgca
81901 taaaatagtt gaaaaaaatt tgcagggtgg tgtgtataga catttcacat aaaatatgat
81961 ggataatctg aatcaaatgc atatttgggc ttacaagtag ctataataac tttgtcacat
82021 caaacaagat gagtaaactg gaatgtcatt tcgttgactg gaagaagcca gcttaccagt
82081 tgaaaaatcg cttcatattt tattgtattt tttgagcctc ttcatttatt acataagtgc
82141 actctcaagg gtaattgcct taaaaaaatc tttgacttgt gaaatgtaga caataccgtc
82201 aggatttcca agtgttatga gttcttttta atgtctcttg ttcaggtgca actgattttg
82261 acagatgtat tgttaggtta ctggtataac atgacatctt ttttcagatg aaatgagtaa
82321 gagtgatttt gacaataagt agataagaca gtcagaaagt tgaaaaaaac atgtcaatgt
82381 cacagttatg ccacaaatac tacagaacag accttacaat atcattaagt cagggtcttt
82441 ccaacaatgt ccttgagaag acagaaaata gtattgccct taaatactac cacttagcca
82501 cagacggaaa ataagacaaa acacaaagat cagtttaatg tgtactcaag gcggcatttg
82561 atgagtctat gctatgtgtg tatatttgtg tatagacctc gttaacatac tgtatggatg
82621 aaagaatttt gagatatcaa aaccactttt tctggagcca aaaaagcatt taactttaga
82681 attccaagaa ctccattaaa aaacattgat tgtgaaatat gcaaagtgat ttaatgtata
82741 ttaattataa ctttgttgaa tggaataaga agaaatagcc tttaataata tgagaaaaag
82801 gccaggcaca gtggctcacg cctttaatcg cagcactttg ggtggctgag gtaggcagat
82861 cgcctaaacc caggaattcg agaccagcct gggcaacata atgaggactt catctccata
82921 aaaaataaac aaaattagct gagcatggta gtgcaccctt gtggttccac ttactcagga
82981 ggttgaggtg ggagggtcgc ttgagcctca gaggtcaagg ctgcagtgag ccaagatagt
83041 gtgagtacca ctgcattcca gcctgggtga caaagaagac cctgcctgaa aaattatata
83101 tatgaaatta tgtatatata tatatgaaat tatatatata tatgagaaat ttaggaatac
83161 atttaaaaat gtatttctag atcatgaatt ttgtaaacag gttagtaaag actaaaatga
83221 aatcaacccc atgtgtcaat agggaattag atgtttggtg gtcatatttt cccttactat
83281 tgactggtca gaagctggac tacacagaca gtccctgact tacagagatt caacttacag
83341 ttttttgact ttacagtggt gtagagacaa tatgcattca gtagaaacca tgcctcaagt
83401 acctatccag ccatgctgtc tttcactttc agtgcagtat tcaataaatt acatgagata
83461 ttcaacactt tattataaaa tggtttttgt gttagatgat tttgttcaaσ a-ataagctaa
83521 tgtaagtgtt ctgagcatgt ttaaggtagg ctaggctaaa ctatgaggtt tggtgggtta
83581 catgtattag atgcattttc aactaacaat atttttaact taagatgggt ttatcaggat
83641 ataactccat cattagttga ggagcatctg tatatgcatg tgtatgagta cgtatactgc
83701 cttttctcaa tatataatgc atttaaaatg atttaatgga aaagatattt atccttagaa
83761 tgccttctac tatctttgtt tctaggatca gaagtggttg atcttgatgg aaaaagttcc
83821 cttctctaca gatttgatca aaaatccctg agcccaataa aagacattat ttctttgaaa 83881 ttcaaaacca tgcagagtga tgggattcta ctccacaggg aagggccaaa tggagatcac
83941 atcacactgc aattaagaag agcaagactc tttttactta ttaattcagg taaaactatt
84001 cggtgaagtg ctcaaaaatc tgattattta gatatcacct aagtcacttt atgcttttat
84061 agcttatctt ttagcagtca gagtgcctta ttttcagatt caagggcttg tacatatgtc
84121 aatattgctc tttcatgtaa aaatggttca tattttgcaa attgcacaaa ate ttcagtg
84181 tttttttaca tagtgctgat agaaccatat agctattttc taacatcata aaggaaggga
84241 tgggtcattg aaaaatgttg aggtagtaaa aataatgagg ttgtggcaaa gataaaattt
84301 acatagaaaa tgagcgtgca atcagtaata atgacaaaaa gaattaacaa cggaggaaat
84361 tacaacaagg ttgagatatt attatattga aacttcgggg aaatgcatcc tagtatttga
84421 aacggaatgc gtagaaggag attgcaatta ttatgaaaga tggtggtcca cagaagggaa
84481 cctttttttt ttttctttag actggcaata atggtgctgt tatttttctc ct ttctaag
84541 gtgaagctaa actgccttcc acttccaccc tggtcaatct caccctgggc agcctgctag
84601 atgatcagca ttggcattca gtgctcatcc agcgtttggg caaacaagtc aac ttcacag
84661 tggacgaaca caggcatcat ttccatgcac ggggagaatt caatctcatg aat cttgatt
84721 atgaggtgtg atggttatgt ttcaattaat gctgatttta ttatgtatat gtggtttaat
84781 ctcccaRagg aaaatacact ataaagagcc caccttttca gtaaatcata gaacaggtga
84841 agcatttccc aaggcagtct aactcacagt ggcagctttc ggtgtatagt act tgWacct
84901 tcatctttct cacagtatgt aaatttattg ttatagaggg agatgatctt ttt tacctaa
84961 aatatgtagt cacagaacat catatgcagg aaatcttctg caccaaaaaa ate ttattac
85021 cacaagcaaa tataggatgt ttgctatgac ttctttgtgt tctagggtat ttgtgagcag
85081 tatagattta taaggagaat gtaccaacaa attgattaat taattcatta gcaatggatt
85141 caaatgctca aatatcaata tgtgStagaa gcgtatctaa aataaaatat tat aattggt
85201 tatagtatta aacagatcaa gttttaccat gttataaaga tgtatttttc atcgaccagt
85261 gaatatcaaa gccagatgtg atcagcaact tgtaaaaata aagttctagt gtaaataaaa
85321 gctaaatgca cataaatttg ttttaaatct atatcttaat ttttgtgtgt gtagggttat
85381 gaaaaattga tctgtgtgtg atgattatag ctatacttgc taatcataat taagcagatt
85441 tttagaaaat cactaaacaa tattattgat gccatttttc tttctaagat cagctttgga
85501 gggattccag cacctggaaa atcagtgtca ttcccacata gaaattttca tggatgttta
85561 gaaaatctct attataatgg agtggatatc attgatttgg ccaagcagca aaaaccacag
85621 atcattgcta tggtgagagt ctttatgcga agacattagt aaaactatat ttσ ttttttc
85681 cacacagtaa aattcctcca ttttaggttc ccatttgaca tggggtttta gaggtactct
85741 tatttaaata tttttctttg attggcaata tgcatataaa agattggttc tat ctgaagg
85801 aattataatt ttgggggcat aattatttta tttttatatg aagtaaagca gtgtttttat
85861 ggttgatatt ttaattttat tgtgatgtca ttactcacag gagcctaatt tct tttaatc
85921 tgtatttttt ttttcttttt tgagatgaag tctcactctg tcacccaggc tggggtgcag
85981 tggcataatc tcggctcact gcagcctccg cctcccagat tcaagcgatt etc ctacctc
86041 agcctcctga gtagctggga cttgtagtcc tgccaacaca cctggctaat ttt ttgtata
86101 ttttgtagag acaaggtttt gccatgttag ccaggctgat cttgaactcc tgaccttggg
86161 tgatccgcct gcctcagcct cccaaagtgc tgggattaca ggcatgagcc act atgccca
86221 gcctgctctg tgatttttta aataagatat tccctgacaa acttaccaga tgagcataaa
86281 gagtttctgg aatcagataa caaccatgta tattagggag acatttgaaa aacttgtatt
86341 ttgccatagt cattcatgat aaataaaaga gacgaacaga caacagcatg taa-gaaacat
86401 cacatgtagg aaatctgcac caagagatct tactaccgca agcaaataca ggt tgtgtta
86461 caatattgca tcggccaatc tgtccaaatg gcaatgttgg tSagactgca tta-cattcta
86521 attctgtgga aacggggaca atttaaatat agctgtcttg gttaggtttc agt tagggaa
86581 gcagcaccaa tgctaggtat tgtgaacagt ggatctatat taggacttgg acctcagcaa
86641 ttttcagagg aactaaaaaa tgaatggcct ggcaggggaa gtgcgaggat ca agaagtc
86701 attaattctg cccaaagcag tgatgtgtgg aggcatgttg gaacttacag acR-ttttcag
86761 cctaggaggg ttgaagagaa ctttggcagt tgttgcctgt gggtagccac cacccctgtg
86821 tgtccccagc catgcatcca gcgatgggcc tgggcttgct gtcggtcggt tggrgccagct
86881 gtcaggaaga agagatgggc catagtgcag gagagcaagg acagactgga acaaaccagc
86941 Ygctgtgtga ccacccctca tcgcacatga ttagaaaaac aaccttaggg gcaaaatgtg
87001 ttgctggtgt tttaattcta actatcaagt atcacccaag ctctcttttt tggrcttttac
87061 tcagaagcag acaagtaagg ggatcctggg aaacatggtt tctagcttta cca-gtttgat
87121 aataaaatac aggcacatat tgatttgaat aaatttcttt cattgcttaa aatccaaagt
87181 gggtaaattt aagctcatgt gtcagcaaat cccaaagcac atcacaagtg tatttattgt
87241 ttaaacagca ttttatttct aattatgtga attggtggta tttatatgac cacaacagcc
87301 agcaagattt taaaatagta tttttaataa aagcaaaatt atttaaaata aaaataaaaa
87361 tattttagat agatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat tttatccata
87421 aaatgagttt ctagaaactg caaggaccat tcactcttca ttggcaagag gatttgctgc
87481 tggtaagcta tcatgcagct atccaaatga tgcataagat caagctgcag gttaatgggt
87541 acaaaaatat gattagaaag aagaggggca ataaattcta gttttcaata gca-cagtagg
87601 gcgactatag ttaataagga tttatagtat atttcaaaat agctacaaga taagttttgt
87661 aatgttctca acacaaagaa aagataaatg tttgaaatga tggacatccc aattatcccg
87721 atttgctcat tacgtattat atatatgtat caaaatatca catgtgcctc ataaatatat 87781 acaactatta tgtatcacta agaaaaaaga ccaagctgca gctggtaaaa atgttttttt
87841 ttttttccct aggtttgata gtcttaaaat tgcctttaca catatgggtt agtgtagttt
87901 gctgttcagc ttttgttatt tcattcattg gaacaatgta tttgtttata ataaaagtga
87961 attcactttt cacagattca taatagagcc aaatgttttc gtttgaccaa gaccaaatgt
88021 tttattccaa tgtgtattct tctaaataag cttgacttca ttgactt tta aatttatatt
88081 aaagttgaga aatggagaga agagcagagc aaagggttga agaacct tta agaaatatgg
88141 cagtggtttg gactgtcatg ttgatagcag gcagttgttt taaatc cgg ataatgtgag
88201 attgaaaagc agccttcaaa ttctgttact aatgtgatgt gaataacatt ctgaaagctt
88261 tttcttttac tttattctca gggaaatgtg tcattttctt gttcacaacc acaatctatg
88321 cccgtgactt ttctgagctc caggagttat ttagcactgc cagacttctc tggagaggag
88381 gaggtttctg ccacttttca atttcgaact tggaataagg cagggct tct gctgttcagt
88441 gaacttcagc tgatttcagg gggtatcctc ctctttctga gtgatggaaa acttaagtcg
88501 aatctctacc agccaggaaa attacccagt gacatcacag caggtaataa atgtattccc
88561 tggggcaaag catatggatt tgaaagattt cattatctct gtggccaaat tttatgcata
88621 accaaaaatg taatatttgc ttaataaatg aatactcagg ttaataagat tataagtact
88681 cttccttaga ggaacttgat tccaattttc ttttaaatat ggttccaaca ctagcagttc
88741 ttattaacca aaatgatagt tttggggaac tgaagtttcc tttcacR_acc ctgtctccca
88801 ctccagacaa agaacatatc ctaaggtgat gtgttttggg gaaaacatga agaccttgaa
88861 ataggccaac aagttaacta agtgttcttc aatggaaaac tagactcttc ctaacacact
88921 tgttagtctt atctggtctg tgagaaaaag ggagaggtct ttctgggatc tatatctata
88981 tctctgtatg agtgtacagt gtgaatggta actttatttg ctgatg ctt atgtaaagag
89041 ttgaatacat tttgagggga tgcaaagatt tatgcaagat tcctcagttg tcaccaaatg
89101 aaattctctc tacttctagg caatacggta ttgttttaat gattagaagt aatgtacttg
89161 aggtgactat atgagtatct ggataatgaa tgtctaattt aggccagjtgc gttgagtgag
89221 ggatgttttt gtctcttcat taaaattata aagttcttga caaaagctct acatcacatt
89281 tttacgtatg tacaatggca tccaagccaa gcaactagag gttgccttgg ggtaaattac
89341 tacattaatt taataaataa tctttaaaaa caacttaaag attccattgt actactcctc
89401 tatattaagt atgaccaaaa aatagtggaa tgtaacttgg agaggagjaaa aaaatgagaa
89461 gttaaaatac agttgaaaat taaatacgag aaaacaagta tacaaatgga tatacaaatg
89521 cctattattt atatgtcttt ttgttgctgt actactattg tagtttaaat acggaaccga
89581 gaattcgata ttagttataa tttttaaaga gatactatgc tgtgactttt tatttagtgt
89641 tcaaaatgtg gtagatttgc tggctagaca aaaagaaata aattaatgag tctcatatta
89701 ataattaata ggccctgaaa atgaaggtct aaaaatgtaa gcttgccatt agtgtgtcat
89761 ttattgtgat gtatctgaca tcttctgaag tggttatatt cataccctaa ttttcagcat
89821 cttaaagaaa ccgcttcagt gcaacgttac tttggggagc tccatgaagt cagcctattt
89881 ctttcttttt tttttttttt tttctgagat ggagttttgc tcttgttgcc caggctggag
89941 tgttatggtg caatctcagc tcaccgcaac ctccgcctcc cgggttcaag tgattctcct
90001 gcctcagcct cccaagtaac tgggattaca ggcatgtgcc accacaccca gctaatttgg
90061 tattttttag ttgagacagg gtttctccat gttgatcagg ctgaagccag tccatttcta
90121 accgctttac aagcatgtat agttaatata ttactaggta taagtctcat agaataccct
90181 gagggattta aaaatttcta aatgaatgtt taaattcatg tataatstaa tctgttatga
90241 catcatctga cttggtatga ttattttcat actaatcata aggatactag actaaatatg
90301 aatgtcagta cactgaggat aacacaagta ggattttatt taaaaactct ctctactctt
90361 ttttttccgt ttctttcaca atattatttt ttgctagttc ccgtgaagca agtacatttt
90421 gcatttgaaa atagactatt taaatggtag ttgggtggga ggtcagcttg ttctcccaag
90481 gggaagactt tccatttatg ttttatgtat gcgacacttg ataattaaac cagttgtcag
90541 gatgtattat aatgactttc aagagaacca tgtctttatt gatggattgc tatcacattg
90601 tactaaatct tttcattata taaggatgga ttaatttttc tcagctactg gagatatatt
90661 ttacaaatct tatatgtttg aaaaactcaa cattttaata tattttataa tgaaattaag
90721 attaaattgt attgagaaag aactgaattg tgcaaatgct tgaattatca gactaaattt
90781 ttaatatgat gtacagtttt gcaaattgtc atttggaatt attcaaaaat attatgtcag
90841 cttaaatcat ttttgaaata ttcaacacat tatattagta taaatcatga aacatattag
90901 catcactata aaatccctta tgacacaaaa tatttttagt cgttgccacc tttataaatg
90961 tcaaagcaaa aatcaatgag cagtacagtt ttatgttccc atttaaaaca aagtttttga
91021 tatcaaattt gagatttctg ctatgatttt agcatttctg ctgctgtttt tgcgtaacag
91081 tgaaaatcag gcttataacc atgcctcttg tccccatggg cagggcctgg cagaggcagg
91141 cttgcagtat ttgagatgtt tctgcatttt tctattacta agcattctca attcttgtgc
91201 ctctgacaat ggagcagccc ccttgatttg ctgcacccag gagagccatt tttgtcaatc
91261 caccttcctc cctttcactg ttgaaatatt cctaactttc gggctgtaaa cctgtcaccc
91321 tttaaacttc tgctctccac caaagtgatg ggtaccaacc acctccatat tttcatcttg
91381 acaagagcta tctggtaatc tgaatcctta attctggtta gtgactacgg ttagtggata
91441 taagaatgtc tggcacttca gtgcgctgaa atacgcttgg aaagaggcaa caccctttgg
91501 tttttccctg aggaatggcc taggtataat tgccttttgc acctttgctg aactcctacc
91561 ctatatggca ggctaatttt ttttcttata cattgtgcac tacagatatg tgttgtagtc
91621 ttatgagagg gtgatgacaa ctaagctctc atgtttctga tgcaatttag gactggaact 91681 agaagacgat ctgtagaatg gaagtagacg taaatctttt ttctcctgct gtattttgta
91741 tgtttatgtg gtttaggctg gaagacagaa caaagagagc aacagaaagg gaaagagaga
91801 gagaacgttc taggccataa tctcatggtc tccaacgtgt aattgcaaac acttccatct
91861 actattccat ccttccatta ttccaattgg cattgtcaat gttttccatc caaagactgc
91921 aattaacata tctggagtta aacaagttga atttattgct tattgcaaca cagagaacac
91981 accctggaaa ccaacggttg tctgaagaca aagttgttag aatggcatag gatttggggt
92041 tgtgttagct gatttgaggg aggtttcaag gaagtgaaaa attgctgtag actaaatgct
92101 gtcacgaagt gagggtaatt ctatgattaa atatctttgt aaaccttatc tagaaggatg
92161 aaataacgaa gtaaggctaa agttgtaatt ggtaaataca gaacaaaaca gttggtcatt
92221 cataagtatc aggagagaaa gaagtttgtg tttttgaggt ttgtacaata gccttgcttc
92281 tgtctgtgtt tagacaagtt tataagtagt catgattttt ccccaccttc atttcattat
92341 agtcacagaa tggccttgtc tgatgttggt gttctgtgtt attgttgatg ttcaacagaa
92401 gaacaccaaa gcccagccct cagtgccagc cagattctta caacaccaag gtctcactgg
92461 tggtaccagg ctgtgtccta gctgttgcgg cctatttttc ttagagttaa ttgtttaata
92521 tgagcaaaaa ataaataaaa taaaataaag taaggcagac acctgtcttg cagacaggga
92581 agagtgtagg ttttggagtc agtcttggtt ttctgttttc cttcagctat ccagcagctg
92641 gatgtgacct cggtagtttc ttttcctctc tgagcctcat tttctccgta tttaaggtga
92701 gaatgataag ttatagtgaa gattaaatga tactatgcat agaaagctcc cagtatttgt
92761 tataagtaat acctcaataa aattactatt ttattattat gacaacatgt tcctccccag
92821 acttaaaagt tatgagtggt gggactgggt gcatagaatt ttcatttact tacacaatat
92881 cagaaacaag aaaacaaatt caaattctat gatttctcct tctccttcct gtttcacagt
92941 ggtgcggccc ttgaaaaggg ccaacctatt atcagaccta gtaacggaaa ggagttgtat
93001 agctacaaaa caattagaat ctaatttaaa attaggtaga gttagttgaa atgagttaaa
93061 gggacatttt gtgatttgag taataaattc caattgacag gtattaagtc tcctcatcat
93121 aggcaaataa tgtttgttac aaaggaggct tgggaaaagc tttctgaagg ttcccccaca
93181 aacatggcac aacttcattc tattcacaac ctgtaacctg ctagcttgtt agatgaatgt
93241 gtttaaatgt gtgccaaatt acagagtggg ttactctggc agtcttttgt tcctgatcta
93301 ttttttgctt ctgtatggac agtaggcctc cccaagcctt ttagttaatc ctgctgcatg
93361 cctaaccaat gactgcccag agccctgcta ctcaaagtat gggtcctgga ccagcactgg
93421 ctcagtgaaa tacttttaac tgatctatga tgagatgaat gttaaaattg agattaaact
93481 cctagaaact ggtaaaaaga gatcactgca acatctaagc acatggttag tgggcttgta
93541 ttttatgtct tatttatttg ttattttact ttttattttt ttttaatttt agatttgggg
93601 gtacaagtgc aggttgttac atgggtatat tgcatggtgc tgagatttgg gtttcaattg
93661 aacccattac ccaaataatg aacatggtac ctgataggta gtttttaaat tcttgcccca
93721 tgccctctcc ccttttgaag ttcccagtgc ctgtttttcc catctgtatg accatgtgta
93781 cccagtgatt agctcccact tacaagtgag aacatgctgt atttggtttt ctgtttttgt 93841 gttaattcac ttaggataat agtctccagc tgcatctgtg ttgctgcaaa caatgttatt 93901 ccattctttt ttatcgctac ataatattct gtgatgtata tgtgccacat tttctttatc 93961 caacccatca ttgatgggca cctaggttga ttccatgtct ctgctattgt aaataatact 94021 acaataaata cgtgaatgca ggcatctttt ttggtcagtg gtcctcaacc tttttggcac 94081 cagggactgt tttcatgaaa gacaattttt ctagggactg taatgttggg ggatggtttc 94141 aggatcattc gagcaaatta aatttattat gtactttatt tctattatta ttgtaatata 94201 tagtgaaata attatacaac tcatcataat gtggaatcag tgggagtctt gagcttgttt 94261 tcctgcaact agattgaccc atctgggggt gatttgagac agtgaccatc aagcattaga 94321 ttctcattag gagtgtgcaa cctagatccc tcgcatgtgc agttcacaat agggttcgaa 94381 ctcctaggaa aatctaatgc tgccagtgat ctgataggag gcagagctca ggtggtaatg 94441 caagtgatag gagcagctgt aaatacagct tcacttgcct gccagccact caccttctgc 94501 tgtgtgatcc agttcctaac aggccacaga cctggtatcg gtccatggcc ctggggattg 94561 gggacgccta tttttggtag aatgacttat tttcctctgg gtatagaccc agtaatggga 94621 ttgctgggtc gaatagtaat tctactttta gttctttgag aaatctccaa actgctttcc 94681 acagaagctg aactaattta cagttccccc tttttttttc tgtagccttg ccaaaatcta 94741 tttttttagt aatttatttt catcatattt tataaaagta tcaatttgca atagatcaga 94801 taataaaatg ttcatcccca cagatagttt gagaagaact gttggacacc agtggaaagt 94861 ctaaaatgaa ataagagaag tagagtcttg cacacagggc tttgagaatg agatgtcgga
94921 gaaatgccag gggcaggtgg gtagaatata cacgtgacac agagagtgta taagaaattt 94981 ctctctaaat gagtgaaatc tatcttaaag gaagcactgg atgacaaatc taggacatct 95041 gatttatttt aatccagtcc tgtaccatca aggattacat aactctattc agctgtctat 95101 ttcagagtcc actcttagaa aatgtgtcta aatgtatcta acctacattc ttcccattcc 95161 agttttcagg cctttcctat tatcttacac aaaccaaacc agagttgggt cttcagtaat 95221 ctttttttgc ttcatggatg tgatgtaaaa gtgagcttct gtgccctggc taaaatttgt 95281 gttagaccat atatgtccag ggcaaagaca tgtaatcacc taagggagtt ttgatgcatt 95341 tttgatccaa atgtatgtgg tagaaattct tcgggaaaat aaaagaaatc acatatatca 95401 catatttatg taaacttctt ttacataaaa tcagtaaaga aat cacatgc aatatcagaa 95461 aaaaggctgt ttggttttga tagattgctt atttttttgt ttcttaattt gatctgcaga 95521 atcacacaga gttgactatt caaatggatg taaacctgac tggtaaattc acgacaaaga 95581 ctcttagatt tcacctcNgc tcaacattta gctacacagc tccttgtaga atcgattgtc
95641 tgtaagagga aaagtctatg cattctgatg gattcatgac actggggctt ccttaggagg
95701 gactagagat tgctttttag aggtgataag aatacctcga tttttgattt tagcaacttt
95761 tgactttata catgtctaca tatatataaa cttggaaaat
GPR50 genomic sequence (SEQ ID NO: 12)
>X:GPR50
CCAGTGGCTGGGGTCTTGCTACCCACCTCCGAGCTGGAGAGCAAACCACC[A-/G]GCCCTCCTGCCTCTCACTCCTGTGCCTCCCC CATTCCCTCATGAGCTCTA
APOL3 genomic sequence (SEQ ID NO: 13)
>22:34781351-34880400
1 tacacttttt tttttttttt tgagacagag tcttgctcta ttgcccaggc tggagtgcag
61 tggcactatc tcagctgact gcaacgcctc ctgggttcaa gctattttca tacctcagcc
121 tcccaagtag ctgggattac aggtgtgtgc caccatgccc agctaatttt cgttttttaa
181 gtagagacag ggttccacca Ygttggctag gctggtctca -aactcctgac ctcaagtgat
241 cctcctgcct tggcctccga aagtgctggg attacaggcg tgagccacca aacccggcct
301 gatacacaat tgtctatggg agaagcacag tgaatgcact ctgatttagc aatcttattc
361 tcttgaatgg tttgtgcttt ttatgtctta ggaaaccttc cttggtccca agatattcta
421 tagaRacttt attttgtact tttcttctaa aagtcttttc tttttttttt ttttttgaga
481 cagagtctca ctccgttgcc caggctggag tgcagtggca cgatcttggc tcactgcaac
541 ctccgcctcc tcggttcaag cgattctcct gcctcagcct ccagagtagc tgggactaca
601 ggcatgcgcc accacgcctg gctaattatt gtatttttag tagagacggg gtttcaccat
661 attggccagg ctagtcttga actcctgagc tcaagtgatc tgcccatctc ggcctcccaa
721 agtgcaggga ttacaggcgt gagccaccac gcccagcctc taaaagtctt aacgttttgc
781 ctttcacatt tacatctgga attgattttg ttatgcggtg aggaaagaat ctttttattt
841 ttctctttgg ggactcaccc cccactccat ttgcaggcct gttgggaggt aggctcatct
901 tagaggaaca gaccctgggc aggctgtgac acagggctcc agcaacaagc cgcagaagcg
961 gaactcataa catgtggcat tggcattccc taccattact gattcaatgc cattccacgg
1021 tggccctggg tcatggacca gctcatgttg ggctaatgtc ccaacacaca caaagatggt
1081 aggtttgact aagcMagagg cagtccttag gtgaggttgc agggagaggg aagagggctt
1141 ggtgaagaat agaagaccca tgaagaaggg gtgtggtctt cggtgaccacg tgatcccata
1201 gtattcccat agacactcaa gacagctggt aaattgagct gctccccaga ggaggccaac
1261 agacaggctg gacaatgact ggggtctgag cagagacccc gtctcccttc tgctgcacct
1321 gctgcagctt aacattgact agactaccag gctcagcctc agcaaggccc ccacctggct
1381 ctgggcctgg tgaccaggga aggtgggaag agagggggct catcacttcc tacagaagga
1441 agctcagact tccaatttcg tgtggcataa gagcatgggc tctgggcaac actgcctgga
1501 ttagtattca gctcgggccc tactcgtggt ataactggga gtcactaatt ttatctctgg
1561 gcttcactat aaatgggatc ctaatggcag tctacccaag cagggtattg tgaggcctag
1621 agatgatgag gcaaacagtt ggttctcaat acaagaaaga aatttatcat ttgcatgtag
1681 ctgcatagct gataagccca tgacagtttt cccataacct gttttcatgg ccttattttc
1741 cgcaactctg tctatttcag ctacgtggaa ccactcctgt gtactgtgac agtctaatgt
1801 tgggatctgg ttaaatatat tatggcccat ccaggcgcgg tggctcacgc ctgtaacccc
1861 agcactttga gaggccaaga caggcgaatc accctgaggt caggagttcg agaccagctt
1921 ggccaagatg gtgaaacccc gtctctacta aaaatacaaa aattagctga gtgtggtggt
1981 gcatgcctgt aatcccagct actcgggagg ctgaggcagg agaattgctt tgaaaccggg
2041 aggtggaggt tgcattgagc caagattgca ccactgcact ccaacttggg cgacagacag
2101 agagagactc ggtctcaaaa aaaaaaaaaa aaaaagttat ggcccatcca caggatgcaa
2161 tatcatatag ccatttaaaa gaatgggcta catctgaacc IMgatggaaga aaagatgccc
2221 ggatatgtta ttaatgggat gaggcaacgt gtagaacctg tgtaaaatag gatttttttt
2281 ctgagatgga gtcttgctct gtcacccagg ctggagtgca ttggtgccat ctctcctcac
2341 tgcaacctct gcctcctggg ttcaagcgat tctcctgcct cagcctccca agtagctggg
2401 attataggag cccgccacca catctggcta gtttttgtat ttttagtaga gacgaggttt
2461 caccatgttg gccaggctgg tcttgaactc ctgatctcag gtgatccacc cacctcggcc
2521 tcccaaagtg ctgggattac aggtgtgagc caccacgcct ggccaagtag gatgctttta
2581 tgccatattt aaaagaatcc acagggagct gttaatgctg -atacttttgg ggaaagggct 2641 cagtggagca gctaagcttt tgcttttctt tttgttcctt tctgtggaat tggcattgcc
2701 taccaacact gattcagtgt cattccacgg tggccctggg gcatggtgtt ttttttcatg
2761 gatcagctct gcctgacacc accatgcagc aggctgtact gtgagcctca ttttgcaggt
2821 gagagaagca aggcacagag aggttacgt acttgcttaa agacatgtga caagtaagag
2881 gtggagctgg gattcaaact caggcagtgg aggtctggag tccctatttt tagctactac
2941 atgacactgt ctcccaatat attattttta tctatttaaa aattcaaagc agttttctgt
3001 gttatagact attttttact tcttcacatg cttaaaaaca aacaaacaaa aaaaaataaa
3061 acagaggcca ggcacggtgg ctcacgcctg taatcccagc actttggaag gccgaggaag
3121 gtggattacc tgaggtcagg agttcgagac cagcctggcc aacatggtga aaccctgtct
3181 ttactaaaaa tacaaaaaat agccaagtgt ggtggcatgc gcctgtagtc ccagctactc
3241 gggaggctga agcaggagaa tcgcttgaac: ctgggagaca gagtttgcag tgagctgaga
3301 ttgtgtcatt gtactccagc ctgggcgaca gagagacttc atctcaaaaa aacaaaacaa
3361 aacaaaacaa aacaaaaaaa aacaggaaca atgcatagcc catgatgaat tgttttatta
3421 tctgtgactc ttattgttca ttggttgctt ctgtccctct ctgaccacag cctgatggga
3481 ggcacaggcg agggaagaac gtggctttgg gagcaggggg accctcattc tcatcccagc
3541 tctgcacgaa ctgcggcatg accttggcca ggccccttcc cttccttggc ctcagcctcc
3601 atctgtagag ctgggccaat gccggagccaa atgacctctg cgggccctcc tgcacaagga
3661 ttctctccct ctttctgatc tatttttgcc tgacgcctct cccaggggcc tgtgggcctg
3721 agctaatttt cctggctggc cccagtccag gcagctcagg tggagagcgc caagctaatg
3781 aggccaaggt catggtccag ttagcatctc tcggaggaac cgtggctttt cagccagact
3841 gtagctccct gaccagtcac tgcgctcagg tagaggcggg ccctagagga gaggacaata
3901 gcaaagctgg atcctgcaag tcagcatttc cagtaggagc tgctcagggc ccagggccca
3961 gatacccttt gtgactgcag ggcagcatgt ccaggctcac atcaacatac caggatgatt
4021 caaggagtgt gtacgttggg ggttagggag aggaccaggt ggatcaccaa gtgcctgcaa
4081 gtacccccac acctgtcaag tcaggaagat gagaaccaat tctaccttta aatctaaagc
4141 agattgggag gccgaggcag gaggatcacc tgaggtcagg agtttgagac cagcgtgacc
4201 aacatggtga aaccccatct ctactaaaaa tataaaaatt agccaggcat ggtggcgggc
4261 gccacctccc agctactcag gaggctgtgg cgtgagaatc gcttgaacct gggaggcgaa
4321 ggttgcattg agccaagatc atgccattgc actccagcct gggggataga gcgagactct
4381 gtctcaaaaa acaaaacaaa acaaaacaaa. caatctatat ctatatctat atctatctat
4441 ctatctatct atctatctat ctatctatct atctatataa agcagacagc atgtccacat
4501 tctctcaagg tgaccccctc tttctaacat cagaactttc cttttttcta catgaggcat
4561 ttccaccact tttaaatcag atgtaagaca gagtaagcct tcctctttta cctgccacga
4621 gggccagggg ttgtctgttc cttctctact acatccccgg cacctagacc catgcctggc
4681 gtacctacac taggagctca gtcaatattg ttgagcgaat caaatcacca ctgttccaga
4741 atgaggctgc agactgcctt tgaacggaca cagtattgcc agtgggtttg actcagtttt
4801 gttcaaatat ttcaatttct ttttttggtt tgtttttctg agggagtctc actctgttgc
4861 ccaggctggc gtgcagtagc gtgatctcgg tcggctcact gcaacctcca cctcctgggt
4921 tcaggcgatt ctcctgcctc agcctcccaa. gtagctgggg ctacaagcat gcgccaccac
4981 acctggctaa tatttttgta tttttagtag atacagggtt tcaccatgtt ggtcaggctg
5041 gtctcaaact actgacctca aatgatccac ctgcctcagt ctccgaaagt gctgggatca
5101 caggcgtgag tcaccgtgcc tggcctcaga tgcttctatt tcaacgagtc tggtgaagct
5161 tgttatttag agagtaatat gtgaatgctc tagaaaaagc aattctcctg tctcagcctc
5221 ccaagtagct ggcactacag gtgcccacca ccatgcctgg ttaagttttt gatttttact
5281 agagacaagg ttttaccatg ttggccaggc tggtctcgaa ctcctgactt caagtgatct
5341 accctccttg gcctcccaaa gtgctgggat tagaggaatg agccaccaca cttggccaaa
5401 ttattccttt tacaatctgc tacaaccccc tgatttgaac attttgcaaa tttgaatgtt
5461 ctcattaggt tttcgattca gttcagtgaa tgtttattat taagtattgt tattatatta
5521 ttattcatta ttgttattat ttaataaga taattgagtt cttaccataa gccagacttt
5581 gggttaaaca cataacatgt agatttagt aattttcatg acaaatctat aagatgggca
5641 ctactgctat cctactttac agatgagaa actgaggcag acagaggtta agtaaattgc
5701 tcaaccccac atgaatagta agttctggag ccaggagtca aacttcagag cctacactcc
5761 taatcacagc taatgttgct cttcaggacg tactttacat gcaagtacag taactgtcta
5821 caaggcactg gtgattaaaa aatgaacaaa gcctttaaca ggtgaatggt taagcagact
5881 gtggcacatc cacatcatgg aacacaattc agcaacagca cggaatgaac actattgatg
5941 cacacagtaa cctgaatgac tctccagaga attatgccaa ctgcgaaaag gcaatccgca
6001 agagttacgt actctatgat gccatttac tatttatttt gagacctagt ctcgctctgt
6061 cacccaagct ggagtgcagt ggcatgatc cggctcactg taacctccgc ctcctgggtg
6121 caagcgattt tcctgcctca gctttccaag tagctgggac tacaggcgtg caccaccacg
6181 cccagctaat ttttgtattt ttagtagaga cagggtttta ccatgttggc cgggctggtc
6241 tcgaacttct gacctcaaat gatccgccc t ccttggcctc ccaaagtgct gggattacag
6301 gcgtgagcca ccgtgcctgg aaaattatt t atttttaaga tttgttaagt gtagtcatga
6361 gaagcgggaa agagtagaac aaggagttt atctgctgtg actgaacaat caattgagat
6421 aacgcggcac cttcggatca gctgattcc tttatctaac attcttaaat ggacccactt
6481 atagacatga agaatagatt agcaattgcc aaggctaaag tagggatcag ggtgggagag 6541 aagtgggtga ggctataaaa ggacaacaag agggattctt gtggtgatag aaatattcta
6601 tatcttgatt atatcaatgc caatatcctg gttgtgatat tgaagaggct aaagctgcat
6661 ttggtacaat aaaatacaat tagcagccta taaccccaaa ggagaaaact ggccagttgt
6721 gtattaaatc tttgtgtgtt tgcatatgtg acatttaaat gcttaattta tatgccaaca
6781 tttagcattt ttccaagatg ttactattaa cggaaactga gtaaagggta catgggatct
6841 ctctggatta ctttgtacaa atgcaaataa aaatgttaat ttaaaaaaac agaatgaggc
6901 caggtacggt ggttcatgcc tgtaatccca gagctttggg agaccaaggt gggaggatcg
6961 attgaggcca ggagttcaag accagcctgg ccaaccagca agaccccatc tctacaaaaa
7021 attaaaaaat tcagctgggc atggtggcgt atgcctgtag tcctagctac tgcagaggct
7081 gaggcaggaa aatcacttga gactgagagg tcgaggctgc agtgagcaat gatggtgcca
7141 ctatactcta gcctgggcaa cagggcaaga gaatgaggca gacaggagcc cagcctggca
7201 ggaaagggag gttgtattag tcagggttct ccagagagac agagctaata ggatagatgt
7261 atatatgcag gggagtttat taaggagtat tgactcacac gaacacaagg tgaagtccca
7321 caacaggctg ttttcaagct gattagcaaa gaagccagcc agagtctcaa aacctcaaaa
7381 gtagggaagc tgacagcgca gcttttagtc tgtggccgga ggcctgagag cccctggcaa
7441 accactggtg taagtccaag agtccaaaag ctgaagaact tggagtctga tgttcaaggg
7501 caggaagcat ccagcacggg agaaagacca tggaagggag tgaaggctgg aagactcagc
7561 aagtctagtc cttccaagtt cttctgcctg cttaattcta gccgtgttgg cagctgatta
7621 gatggtgccc acccagattg agggtgcgtc tgcctctccc aggccactga ttcaaatgtt
7681 aatctccttt ggccacaccc tcacagacac acccaggaac aatactttgc atccttcaat
7741 ccaatcaagt tgacactcaa tattaactat cacagagggc ttccaatgca gtgacagttg
7801 acatgagtcc tcaaggttag tttgcaggtc acaagggaga gaaggacagg aggcctgagg
7861 caggcaggac agcatgtgRt agtgggctgt ttgggtcttc cttccccaaa gtcatcctgg
7921 gatggtgaga tctccggcca ttcattccat tgcacagagg cattcatgca ggctacctcc
7981 caacttgttc ataaaaatgt taagtgatgg acaaaataat gtctttacat ttttcttaaa
8041 cgtttggttc ctgctgctgc ttatctggta gagaggctca tcagaggaga aaatgaagga
8101 agattccctt gtcaaacatc acaacagaga gcaagcatct ttgttcagcc tgtcaggatc
8161 atctttcaca ttcaatttag aaaaatggca gatgttaatg tttttcctgt taagagataa
8221 tttcttttta aaatgtttgt tttttttttc cccttactat gcctagtcct gctttttata
8281 tgataacagc ctaggagtgg aaagaatgag agtttgggtg acagagatcc ttacatttga
8341 atctcaattc cacttagagg ctatggtcat gacttagagg ctatattaag accaYttaga
8401 ggctatggtc atgaccttga gtccgtttcσ ctgagtttca ctgcctcaga ctaatcatac
8461 Ygaataggcc agtattgcca aatcccagtg ctaggatggg gattaatgag aaaacatttg
8521 ccaaaaaacc tagtatacct tgtgtaatac ctgacacgta gtaggtgctc aataagtgat
8581 actcattgat ttattttttt attttattta ttttattttt ttgagaccga gtcttactct
8641 gtcacccagg ctagagtgca gaggcgtgat ttcgacttac tgcaacctct acctcctggg
8701 ttcaaatgat tctcctgcct gggcctcccg agtagctggg ataacaggcg tgtgccacca
8761 cacctggcta atttttatat ttttagtaaa gacagggttt caccatgttg gccaggctgg
8821 tcttgaactc ctgacctcag gtgatccgcc tgcctcagcc tcccaaagtg ctgagattac
8881 agttgtgagc caccacgcct ggtcaataag tgatactcat tgttaataac aattctagtt
8941 catctaagga tttaaagctg tgtacctttc atagtgttct acaaacagct tcctgatttc
9001 cagcagcttt gcttatatca gccaggatag tctaggttat gctgcagtaa aaaacaagcc
9061 cctaggctgg gcacggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg
9121 cggatcacct gaggtcagga gtttgagacc agcctgacca acgtggtgaa cccctgtctc
9181 tattaaaaat tcaaaattag ccgggcatgg tggtgcatgc ctgtagtcct agctagttgg
9241 gaggctgagg caggagaatc gcttgaacct gggaggtgga gcttgcagtg agccaagatc
9301 gcgccattgc actccagcct gggctactag agcgaaactc tgtctcaaaa aacaaaacaa
9361 aactaaacaa aacaaaaaaa caaaccaaac aaacaaacaa aaaccaccaa aaagcaagcc
9421 cccgatctca gtggttcaca acagcaaagg ctacttcttg ctcacgctac atgtccatca
9481 tggggcaggt gcctctctgc tcYggttgtc ttccctcctg gactcagtat catggagcaa
9541 ccactttctg gaagattgct ggttgccaca gtagaggaaa agggtcttat atcagcattc
9601 attgctgtgg cttagaaatg acacatatta tttccattca aaaσtctttt gtccagaact
9661 ggttacatat tcccacccaa ccataaggag accaggaaga ataatcccac tgtgcatctg
9721 gaaaggggaa aagccagaca aatgtggcca acagccccag tgactaccac cacagtgctt
9781 ttgaaaacca ctgcccagag ccagaaggat ggaggatcag catggcggta ggaggaaggg
9841 agaagccaga ggggaatgag gaggagccgg ggtgcctggt atggagggcc atccatcctt
9901 ggtcaatgtg cagggctggg gccagaggaa ggctgggcgc ctttctcatc tggacccaga
9961 cccagacaga ccccggggcc attccgttct gcaggcaaac aagccagtcc cgctagaatg
10021 tggcagtcac aggctttcaa catggaaggt ggagctgcct ggacgctgtg ttttttttct
10081 gtttgttttt ttgagacgga gtcttgctct gtcacccagg ctggagtgca gtggcatgat
10141 ctgggctgat tgcgcctcgg caaaatctcg gctgacttgc ctcccgggtt caagcgattc
10201 tcctgcttca gcctcccgag tagttgagat tacaggcgcg caccaccacg cccggctaat
10261 ttctgtattt ttagtacaga cggggtttca tcatgttggc cacKctggtc ctgacctcaa
10321 gcgatccgcc cgcccaggcc tcccaaagtg ctgggattac aggaataagc caccgcgccc
10381 ggccagacgc tgtgttttcc tggcactcca cttcatgagc aaaactgtca cagagtagta 10441 tttccctggc tccacccctc cggcgctgct ggattcctga acctattcac ttcttctgaa
10501 gtgctctcaa cttggcctcc ctggctcctt cctggtgcag acatttactc ttcctgctcc
10561 ggctttgtgc ctctgtaaaa ctgctgacgt cacc-agcagc ggctccgacc gcctgtcctc
10621 caaggtcccg ggctgcggct gcgcagcgcc gacagcacga tgcgtgtgcc gacagcgcca
10681 cctcctggct ctgcYgaggc tgttggcaac acgc-agggct cgcagtgcgc ccgcttttct
10741 actgcagccc tcaaaattca gcacgaggct tggctagggg agcttgagtg gctgacactg
10801 tggtctggtt agtttccatt ctgacccatg ctagccgtct ttcagattct agaactcagt
10861 tcttctccgg acctccctcc cagccacaag tctttgaata tgcggcctgc agctgggctc
10921 ccctcatccc cgctcttctc cccaaccttc ttcatcatcc cttggccgat cttgaagact
10981 tagcggaggc agggcgcaat ggcttacgcc tgtaatccca gcacttaggg aggccgaggc
11041 gggagcatca cttgaggtca ggagtttgag accagtctgg ccaacatggt ggaactttgt
11101 ctctactaaa aatacaaaaa ttagctgggc gtggtggcgg gcacctgtac tcccagctac
11161 tggggaggtt gaggtaggag aatcgcttgt acccgggagg cagaggttgc tgtgagccag
11221 gattgagcca ctgcactcca gcctgggcaa cagagcgaga tcctgtctca aaggaaaaaa
11281 aaagtcttag ctgaaacgtc acttcctcga ctcc tcaaat ttagtcaagc ccccgtgcta
11341 tgagatctct ccccttcttg ctggacgggt tggcaatgct ggaggatctt gaaagaggaa
11401 cactcatggg tcaagagcat ttcctaacag cgaacagagg tttcagaatc ctcatgagca
11461 tcggtgtctc cttgctggga cgctgctcac acac tttgtg atcctcagag gtgagatgca
11521 ggcctattaa acacgctggc cttggtgaga aagc ctctgt gggtttcctg tttatcccaa
11581 taagctgatt caggaaagga gacatctcct tcct ctctg tttgccatgg aggactcaca
11641 cctttcttgt ccccaggaca gtggacatct gttt gccaat gcagacctcg tgctcactgg
11701 aggctggaga aggcacgctc aagaaacgtt caaggcatga cagctaccca gaaggcctct
11761 agtgccccaa gagctgctca tcagccccat ttt tccta atattattta aaaatttaaa
11821 gaaattcagt gaaagtgtaa gcatacaggc ataggtagta ggtaaactag aattcactct
11881 tgctggggga ataccaccca gggtttgaaa agat cagaa ggcaaaagaa actgcattta
11941 gtataataaa atacaattag gcagagcacg gtgg ctcatg cctgtaattc cagcactttg
12001 ggaggccgag gaaggcggat tacctgagct ctgg agtttg agaccagcct gggcaacatg
12061 gtgaaacccc gtctctacaa acatacaaca attagtgagt cttggtggta catgccagtc
12121 atcccagtta tttgctgggc tgggctggga tgggaggact gtttgggctc aggaggtcaa
12181 ggctgcaatg agctgtgttc acgccactgc actc cagcct gggtgacaaa gcaagaccat
12241 gtctagaaaa aataaaaaaa ttagcagcct ataa ttccaa agcagaaaac cagctggctg
12301 gctatgcact aaatctgacc agccattgtg tgtaaggcgt gtgtgtgcaa atgtgtgttt
12361 gcatgtatat cgtttaaata gttactttat ttaσ caacat ttacatttaa ggaaatttca
12421 catcaaataa tctataattc tagaatcttc ttaaacatga ggtgggcaac atgagacccc
12481 cacttctatc agtatccatc ctgactggac ccaagtggac agcttgagtt tccagttcaa
12541 tccagttcct gcctggcctc tgctggcctc tggg tttgca atcccaactc cctaccaccg
12601 ccactactgc tgagagcatc ccctctacag tac cagaac ctcactggct gcctgcaacc
12661 ctgggggatc agcagaagag actctaagcc catc tatcag gtaaaaaacc tgaggcccag
12721 agagggaaag tgacttacct agggacacac agct cttagt aaacagagtg gaggccaact
12781 ccactccaac tcagtctcat tccaactctg aga ttaaga aaaaaaaatg tgattttaaa
12841 aatcccaaag ttgtttcctt cctccctccc tccctccctt cctccctctc cctcctttcc
12901 ttcctccctc tccctccttt ccttccttcc tctccctcct ttcctccctt cctctccctc
12961 ctttcctccc ttcctctccc tcctttcatt cctt cctctc cctccttttc ttccttcctc
13021 tccctccttt tcttccttcc tctccctcct tttcttcctt cctctccctc cttttcttcc
13081 ttcctctccc tccttttctt ccttcctctc cctccttttc ttccttcctc tccctccttt
13141 tcttccttcc tctccctcct ttcctccctt cctctccctc cttttcttcc ttcctctccc
13201 tccttttctt ccttcctctc cctcctttcc ttccttcctc tccctccttt ccttccttcc
13261 tctccctcct ttccttcctt ccttcctccc tccctccctc cctctctccc tccattcccc
13321 ttccttccct ccctcccttg ccctccctcc ctcccttctt tccttccttc ctttgtttct
13381 tccttccttc ttcccttcct ccctctctct ccttccttcc tctctttctc tctctctctc
13441 tctctttctt tttccccctc tctctctttc tttctttctt ttgacagggt ctcagtcctc
13501 actctgtcac caaggctaga gaacagcagt gtgεatcatgg ctcactgtag cttctacctc
13561 ctcgggttga agggagcctc ccacctcagc ttccccagta gctggaacca cagtcacgag
13621 ccacaatgcc tggctaattt tttgtatttt ttgtagagat ggggtttcac gttgttgccc
13681 aggctggtct caaactcctg ggctcaagca gtcctcttgc cttggcctcc ggaagtgctg
13741 ggattacagc catgagccac cgcgcccggc caatcgcaaa gtttctaaag taggaaatgg
13801 gattctattc catccccaac taattgtccc caaccactgg tagcagcctg gcttgtctct
13861 gcttcgacaa acacagaggt ctaagctcac actctcaaag ttacactcac atgtctacag
13921 tttggctttc tctcttttac tttttttaaa atttattttc tatttgtttt ccccatgaca
13981 tagctccagg agatcctgag aacatgtccc ctacagtttg gcttttaatc ttatgattgc
14041 aaagctggga tcatgctgca aacaccactc tgcaacgtat ccttσccacc aacccagcgc
14101 ccacacaacc ccctcagtgt gggccatctt tccctttcag gacacacagc acagtccctt
14161 tcttccctca tcacctcaca ggcctgaaca gagcggccaga gaggtggagt cctgcaattt
14221 acctgctcag tctcccatca caggaccctg gacaagtcac tcctctctca gagcctcagt
14281 ttccctgcag gaaagaggag gtgctcagag acaaggtgga tgaaacaatt tctgggcttc 14341 ttgtatctca aaagaaatcc tcttcctgtg gccgggcgcg gtggctcttg cctttaatcc
14401 cagcactttg ggaggctgag gcaggcggat cacctgaggt caggagatcc ccgtcaggag
14461 atccatgacc atcatggaga aaccccgtct ctactaaaaa tacaaaatta gctgggcatg
14521 gtggtgcatg cctgtaatcc cagctactca ggaggctgag gcaggagaat cgcttgaacc
14581 tggcaagcgg aggttgtggt gagccgagat cgcgccattg cactccagcc taggcaacaa
14641 gagcaaaact ctgtctcaaa aaaaaaaaaa aaaatcctct tcccctgtca ggccttagta
14701 gcagcatcct aggggtagcc tagacggggg cagattcctg ggggtggttc taacccacat
14761 cacattaatg atgccaccca agtccattcc catggcacca ggtcactggg acaaagggcc
14821 aggtctccag tcttccatgt ctgacctcta cctcctttgc ttcctccaaa gtgcccagag
14881 aaatgcacgt ggcccacggc tgctgccttc tgaggtcacc tggccat cc ccaagtagtc
14941 tgggaaccca tgctgagcct ggagaatctt cactctccca cctctccctc cattcctcag
15001 gggaacaagg actccaaaag agccgtcgga taaacctggg tttggatcca ggctttctac
15061 cttggacaag ttacctaaac ctcctgcatc tcggtttctt cttcgtcaaa tggggacaat
15121 acttctttct ttaaaggctt tactttgagg atgaggtgag agggaagcca tcctcctccg
15181 taccccacaa ggatcacagg ccagtgagat ccagctatta tcacctctgg tgatgctggt
15241 cgccaacaac ccaaggaccc ctgttactga gctctaacca gaccctccct ctagtatcca
15301 acacatactc tcaagggaaa cagaaatcac acagaagagg ccaggcaggc gcagtggctc
15361 acgcctgtaa tcttagcatt ttgggaggca gaggcgggtg gatcacctga ggtcaggagt
15421 ttgagaccag cctggccaac atggtgaaac cctgtctcta ctaaaagcac aaaattagcc
15481 gggcgtggtg gcacacactt gtaatcccag ctactcagga ggctgaggca ggagaatcgc
15541 ttgaacccgg gaggcaaagg ttgcagtgag ccaagatcgt gccactgcac tcaagcctgg
15601 gcaacaagag cgaaactctg tctcaaaaaa aaaaaaaaaa gaaagaaatc acatagagga
15661 aataaattgg ctggttctat tctcaacctc agctccgctg ctccactggc taactcagag
15721 gacagcccga gtccagccat gacccactgt ccagcctcct ttcctgcagg gaaccagctt
15781 gggtttccag gacgacacac tggcccgaag tcttactccc agtcgcσact gcactcctgc
15841 ctgggcaaca acagtgaaac tccatctcaa aaaaaaaaaa aaaaaaaaga atgatacaac
15901 ggactctggg aactcacggg gaaggttgga aaggccaggt atgcgggatg gtattggcaa
15961 ggacacatat agagacacag agaaggagca tcgtaggggg tatggggaag ctatgcacat
16021 ttcaaagtat tagtagagca caaggaagag gctgggacag ggggaggatg aacttggaga
16081 agccatgact ggaagcctgt gtcccatggc attgtcatct gtgtgtgtgc cccatcttga
16141 ctttgagctc cacacaggac aggactctga ctcatctttg ttatagatct cagtgagtgc
16201 aaggcacgaa gaagaagggg tgtcaatgag tgcttcataa atgaatgatt ggatgaatga
16261 atgaatcatc tgtttctcca cttccattct gtggtctccR gccaacattc cctcccattt
16321 acctctcatt aaactctttt tgcagcagca ctttctctta gttcttcctg tcatttgcta
16381 gacttcagct ttgtgatctt tgggtcagac accatgatga gagatgcaga tcgcaactga
16441 gcgKcattta aatattcaga agagctgagg ctccgcaggc tgaattctga atatgcagat
16501 aattcagaaa acactggagc aatagacttg ttgaattcaa actcgaggtg gagcagacga
16561 gggtacagct cggcttaggt gacccatcgt ccccatcagc tgctccttcc caaagctacg
16621 gctccctcgg cctttgagct ttcaagcctc agcctcgtgt gttgcttcag tggcagctgg
16681 aacattcctc cctgcagcct gctcctcaga cgcttatctc accccatagg gccctgctcc
16741 atctcagtct tggatggggt tagcagtgtt ttctggatca aagtagcttc tttccttgtg
16801 ctgtatttaa actttgtggc gtaggcatca gtttccctaa tgcctctgtt atccatcttg
16861 caggtctaca gtattgagag acagaaagtc aagaagttct ggacctgrcca ggaattccca
16921 ctgtggaaac aaatccaccc tccttacttc ctggagaggg gcaattcctt caggaaggtc
16981 ttccatgagc cttacatcag actttgtcct gaactccacc cacagctccc ctgtctgagc
17041 gtgtcccatt ttctctggac ctctttcatc tccagtccca gaccagσatc ctcctgcatg
17101 tgcttctgaa agtacaggcc actcctgcat cccttctata cctgggtcgc caggaaactc
17161 acggatccac ttttgacgca gtctgttctg ctctcccttc tcaaatctgc ccagatctca
17221 gctgtccccc atggtcctta tcaaactccc atctacagcc tctagaaagt gacttctgat
17281 catttcctct atcgtggccc tgaatggcag tcacatgtac ccttcatctg tttggctctt
17341 gccccctgcc agacccagca gcaattccat gcccctgtct ttctggatct cagctcgaga
17401 ggagtttgag gtgcgtggct tgattttcgc ccatcattct gtcctgtctg gcttgcatgc
17461 cttacctttt cttcacagga aatcccatca ttcaatccac atgttgcttt tccatgtacc
17521 aatattagat tttcctagtg attcttttct gatagtaagt cccaaatctg tcttttagcc
17581 aatcttatcc Ytccctgatc ctctgagaaa ccagactcct agatacggac ctttcaaatg
17641 cttctttgct tctgggcttt taataatccc cctgagatta ttcaccagct aaaggatggt
17701 ggggacagaa cagcacttga ctgataaagg cccccatcct cctggtσtgt cactctcaca
17761 tcccaccgtt ccctggggta ccccctggag gccagcacac gacctctcca gatccctgtt
17821 gacaccactt gttggggaaa ggcagctcga gcatcccatg gacatccgtc tgaaaggttg
17881 gccccaatct ggttccttcc ttgatggagg acgacattaa aagaagacaa aggagagaat
17941 ttggggtgac tgatctattg ctgcttaggc caagtctaac cattgaaNgt ctccaaatct
18001 cacacctaag ggtccctagc tcttgtagaa caccacagag attttccagt tcaaggtttt
18061 ggtctatcac acgatgggag aaagctggca agaagaaaac aagctgtggg aatcaacaat
18121 tgttttactc accaaagatt aggaagcctg aataacaaca tcacctcttt tgagtacagc
18181 ctcacataga actgaactga atagaaatca tctcatttta caatcatcag acatctgtct 18241 ttgccccagt cctggctgct gcaccctcac tacgagccct ggattgccac grtcgtccctt
18301 ggttcccaaa tcctagcccg tggatataca tttcttatcc taagagtcac cctactatgt
18361 gagggttctg ggagcagctt tgttcctggg aatctgcagg caccttcctg ccttcctgct
18421 gtggtcgcca ggcacaagga aagaaagaag ggtctcgctt attacagtag ggaaaacatg
18481 cgatgaattc tcttctaacc ctggtgcaga aattctccta atgagtcctg gggtgaaacg
18541 caggcctgga agcgaggtga ggctcctccc caccagcatc taaaaagccg gctccctgga
18601 gccacaggat ttttccaatc agccatggga ccagggcagc ccaccagcct c cccagctgc
18661 cagacgctgg tagagagacc tgagacagag ggcaggtgaa tggagcggga gaggaggaga
18721 gaagggacac cagatggggt ctgaggaaga aagaaggaag aaaaaaagat ccttgatgg
18781 ggaaggggaa agccttaatc tgcttctcaa tcgcgaagta ggtctgcttc t caatcatgc
18841 agtagggagt gaaaagcaca ggtggggctt ttgaggctca ggcactccac c caccaggac
18901 aatgcggacc ccatgactgc agagcctagg ctctgcaggg agcagctagg gagacactag
18961 taagggaggt gggcaggggg cagaggcccc tttcccccac tgctcccacg gggatgagga
19021 gggggcttcc gaaaaggccc aggttagggg gcctgcctgc tcagctcaca tccccctggt
19081 gtgacagtgc cttctttact ctgtcctcta gccccNggga cccatctgag tctctcccct
19141 ggaaattgga ggacctgaaa gaaaaccctt ggaggcagca ggcagtggag ctgaggcctt
19201 gagtgtagct cgttccctac cgctgagagc cctgaggctt tctgggtccc tggtcttccc
19261 taagcctgtt tttaaaaaat gtgcacgcac gcccacccac ccaaggattt ctttaattct
19321 gtgagctttc tctctggatc attcaaatat atgcctcYac tcttgaggta gcgggaagat
19381 tttttaagat ttttcatttg tttttgtttt tgcatttgct tttgtcttgg ttttgctttg
19441 ctatgttcta cttgcatcca aagggtccta cctaatagaa aaattggcac caaagggttg
19501 gttgcagacc acaaagcctc aggataattg gtacaggtag aatcatgttt tgtgttgaga
19561 ggtggacaga gcaatagtga aσccttctca cccccctcat tctggggagc acctgctctc
19621 agcttgtgga aaggggacaa ggaatgctgg gacatgaagc aggaccactc actttggaca
19681 aaggcctttg acatttctcc tgaaggcgtc caataaattg tggctgttga tatttttggc
19741 tgactctcct atgaaaaaca aattcagaaa ccgtttctat aggtttctgg ttacatgatg
19801 aatttcatcc tcactagatc ttctaagcgc acatgagggc cctgatgggg acagagtggt
19861 gtgctagtac ctctcctgct gtaacaaagc cctacagaca cagtgacttg aaccaacaca
19921 aagttgttct cttccagtag agttctaaaa tcaaggcatg ggtagagctg cattccttgg
19981 ggaggctctg ggagaagcaa ttcccttacc ttttccagct tttagaggca cctgctgtcc
20041 tcagctcctg gcttctccct tcgtcttcaa gccagccttg tagcatcctc tgatctctct
20101 cagtttctct ccccttctat catctcatct ccttttctcc ctctcaccct actgtctccg
20161 ccttataagg acccttgtgg ataccttggg cccacccaga taatcgcaga taacctctca
20221 tctccagatc cttgactgga tcacacctgt gaggtccctt ttatgatgga aggtgacata
20281 atcacaagtc ctatgattaR gacacccaca tctgtcaggg gctgttattt agcctaacac
20341 aagatgtatt cagaaaattg caatagggat acctgagggg aattgaagga tcccaactcc
20401 aagccgcatc taaggatgct tccgaggtgc agctcccgct ggaggactct gctccatctc
20461 tcttcctgtc tgccgctgcc tgcctctctg tttctagaca gccagtgttc aagtcagtat
20521 ggccttgaga gtgaactgca gaatggaaag gagtgagatg ctgcagcagg agaaagagct
20581 cgctgtcaaa gctccgaaga gctgaagacc atttatttgc atggtggggt ctgacggagg
20641 tcggcaagga agaggaatca tcatttggWt tccttgccat ggtcatcctc agctggcacg
20701 gtttgctcca gcagcaggct gggattccag ctgtgcccag tgttagccat gccaccctca
20761 actaaatgct gatcacttct ttgtgacata aaaagccaga aattagttgg catgatgaag
20821 aagaaggagg actcaaagtg tgtaggaggc tgaaatgcta gatttgattt ctcaagcact
20881 tcctgcccac Rctgtttcct gccagggccc aaaagatttc ccgctccttt aacgagaaga
20941 gtcaatggat aaccaggaac tctctataat aggggagggg ctgggactct ggtctcttta
21001 gggtgggaga aattccaaga ggccgactgt aggggaggca ggtaactgcc agaagaaaag
21061 agagtgcggg cgccaggtca cgcaccagga gggcgcatga tcatggctca agggacattt
21121 gataggaaca aggttccaaa atagagctgg aagacagtcc actgacttta caaaaccccc
21181 aatctggtga gtggatacct gtcacaggtc atcaggctgg atagtccctg ct tgtcaccc
21241 aattcttagg cctgggtcag agggggagat tatagggcac aagtaattag tgaatatcta
21301 tattcgttta cctttgatta agtccatcag ggtcccaccc tcacctggtc a catttttc
21361 aaattcctgg gtggataact ggaaagaata ctcttggaag cttcagattg tt cacccaga
21421 cccacggacg gggactattt cagtgacata Ygccagtgga ggccattggt tt tacatacc
21481 tgcctaaata ttttactcaa agtcaacacc aacttcatgg aggagttaca gaggcagtta
21541 cagagatttc tgccatcatc aagatttaaa gggagcagaa gcagtgattc ctgtgactca
21601 cctgttcacc tctccagtgt ggccagtcgt caacagggaa acaactgttt gt ttccaac
21661 cgcagaacaa agtaggaagc tcatcaatgg aagttgccat tcctaagttg ttcttgttaa
21721 tgaagcaaat aaacacagcc tgcagctctc agtctgtatc aatcaggctt ct ggtcgag
21781 cagaggtacc aactctgttt tcttagggca gaaaacaaca tgaaattcac tggaatgata
21841 ccagaagaac cccacgtgtg taggaggctg gaaattggct tggaagataa atagaagcca
21901 agacagtgag acggtatcga aggctgcgag cacaagagcc ctgctttgtg aggagtgaσa
21961 cggccacagc gctgcccYgc cacctgcgga cgtcatctct gctggtgcag gactcggtcg
22021 tccccgtctc tattcccctc ccgggcagtc ctgctgctct cactgagaat ggattctaag
22081 caccctgggc tttgcctcac ttgctccaga ttcaggatcc catgtggaag cagccaatta 22141 gccagcctag gtcttgtcca gaagccctgg atgccagggt gggggtggac agagagtcat
22201 ctattctctt gggcattaca tagaaggtgg gaccagtctt tctctatgac tccacatgct
22261 gggaaacccc acaaaactag gaagaggcga atagatgcca atcagctccc tcccaggaaa
22321 ctgggagttc attccaccca gaggcctaaa atgttgacat gccgtctttg agtgtagagg
22381 gaaggaagct aactccaatt cgcaaaatga ctaaatagag ataaatgact gacagctcag
22441 aaaagaccat gagggctgaa ttcaggtgct tacacagagt catgagtact cagcatctct
22501 caaattgtgc tgtgctttcc gcctggccca cctgctcccc ccaggtctgg cctgctgtgg
22561 aacgcctctc aaggacggtt cctgaagagc aatggagcac acctcacagt ccaggctgcc
22621 tggaaggagc tgcatcctcg gaccaggatc tgcattgttt cctgggtaac aactaaggaa
22681 ttagctggaa tttcaacatt ttagaaggaa taaatctgga ggcttggtga caaagatttt
22741 tagggaagag gaacatacat agagctttca gaacaacggt agaaStaaaa aaaaatctgt
22801 cccatgtgaa tgctcattgg aagatgtcca ccatcaaaaa agactctttt tttttttttt
22861 ttgagactgg gtctcactgt atcgcccagg ctggagtgca gtggtgcaat ctcggctcac
22921 tgcaacctct gcctcccagg ttcaagcaat tctcgtgcct cagcctccaa agtagctggg
22981 attacaggca cccgtcacca tgtctggtgg ctagtttttg tatttctagt agaaataggg
23041 tttcaccatg ttgaccaggc tggtctccaa ctcctgactt caactgatcc actcgccttg
23101 gtctcccaat gtgctgggat tacaggcgtg agtcaccatg cctggctcag aggctgttaa
23161 taaacaaggg aagaagtcac tctttaaggc tcaaatctcc tctgttcccc aggcagcctg
23221 acattttcag aatgggctca ttaaccaact tgcctaatgt ggagctctat gtaaccacac
23281 aacacggacc ccactcatca aggctgacca cttggcaccc agtgaatctc aaccccggaa
23341 atgacagcct taggtcccat ggaaatggcc caaaggggac tcagctccat atcagaggct
23401 gggagctgcc cttaggatgt gatatgtttt gaatccatac ccagaatttt ccccatttcc
23461 tgtaatagcc agaattcatg gagctgggca gtcagaggtt aagatgaggg tgatagctct
23521 atggttaccc acaataaacc actttcaaaa attttgttta tgatacatac tcctaactca
23581 cagactttta ggtctggaag tttcagtatc taaggttgac aaaagttgtt tcagcagaaa
23641 ccatagctgg cttctcatgc tccctgatgt agggatagca atgacgtcac tgggttggat
23701 ataatcatgc atcatgttcc tccagggaag ctcatgttgt tattacacag caggacagga
23761 ggaattgagg gatcccctag gattgctcct tgtaatactc taaagtgtta gagtattagt
23821 gtaaatgtga ataggaaatt tcaccaactt actgaggcca gaccatcaag gagcttagac
23881 accacgagaa tgactttgcc cataagtaag aggaacattg agtggaacaa ttcaagactt
23941 ctgatggtgg cagcaatggt cagtagtggc tgtagccttg accgtacctc tttattttct
24001 acaaatatac acacacaaaa attctgagac agaagctgcc aatggaccaa aagaaaaatt
24061 gatcgtgtgc tgaggccctc ctcctgtgac ataacttcag catgcagaag gtggagatgc
24121 tgtgtgtggc tctcactggg gaagaggcaa gtgcatttgc ctttttcctt gggatggctg
24181 ggttcatagc agataaggag agttcttttt gtttgtatga gaagaagagt gtgtgtgcag
24241 tagcaagYga ttgactgtat acaatgagca caaattcagg tggctgtttg gccagaggct
24301 tcccattagg gtttgtgtct ctgttaccca tccccattcc tgataccata gcctcactga
24361 ttagttcaag aagagtcact aacccaagct attctgtcta ctgagtatgt gaaactttaa
24421 tcagagacac taggaatcaa agtgtgtgga gctaagccag gtgcaggcag agccctgaaa
24481 gggcaaacca tatattcctg atgttggtaa tggtctgctc ctgtccttcc aaattctgta
24541 gattttgttc ttccttccat cctctgacct gctctagttt tcatccaatg aatcttctat
24601 tttgtttaag acagatagtt tctgtttctg ttgcttgcaa ttgaaaaatt tttaaacaat
24661 actagcagta cagtggaatt gcatcaaatg caggtagcct gatggcattt caactctaag
24721 tgtcagggca aatgctggct ggatcactga agaagtaaat tactcagtgY cagaaacatt
24781 caaagcttaa gtgaaatgta tgaaaagaat gggaattatc caggaattga tgaacaattg
24841 acaRacaaat gaaacacaat gttctggcgt taggcaagtc ggtggccgtt gctctgttga
24901 cttcttcagg aagaaataga tgaatcaact gaaggtcagg gaagccttgg ctgatggaga
24961 gttacaggga ctgaggcaag tgttctgcag gatgctacat aaaaaaggac taagtaggcc
25021 ctgggtgcac tttacgagtg acttaggaga ggttctgggg tgattKtgtg cattctgtat
25081 ctcttgcccc tgctcYgggc tccagctgag gcgcccagca gttctatatt ctatgcatgg
25141 aaatacagat aattaatgtc cactggggca aggccatggg ggacaggagc agtggttaca
25201 ggcctccctc tctcctccct gtagaggaac attctgaaga cgctccttga agactcctca
25261 ggaggtctcc agtcgcccac atgggtgacc ctatcaagaa tttctcccRg catcagcctt
25321 ctgtccttct ctgtgtcact cctMccagta ccccagtcct gctcctagaa tcacttccca
25381 aacaaatcct ctgcctggga gccttgccta gggctctccc ttcaggggaa ctcaggccac
25441 agcagcctac attagacagc atgaaggctc tgggcttttg tgctaagagt aataggaagc
25501 cattgaagac atggaagcat gggcttgaWg aaatctRtgt tcttacgggg caaMttggcc
25561 cagtgtggag gatgggcagg gatagtggca agggctgtat aacagggaag accattctgg
25621 aagcttttgc aggagtctgg gtgaaatgag agggctgact ggatgagggt gtttgcagac
25681 tggatgaggg tgtttgcaga ctggatgagg gtgtttgctg tctggctatc tctctctgtt
25741 cctctatttc tcatggactt tctctcaacc tacacacagg cccctctgat tttagtcagc
25801 cttgtgtgac ccatgtcatt cgtgggccct ggctgctaga tggggaccat gcctgcactt
25861 gggccaagcc agatgtctac aagctttccc tgagtgcctc acaggccact gggcactggg
25921 gtcgcccaga aatgaccgac cagaagaaca agcagaaggg gccatggagg cctagctccc
25981 tgagtccctg gaagaaggat catgaggaag tgaagtcagg caccgagagc ccaggggagc 26041 ccatccatca gcaccacaaa ggcacaggca tagatcagtg ttgcttgaac ccagatctcc
26101 agaacacaag aggagagagc caggtggacc tgagatatca tcttgtccag cccctctttc
26161 ccagctgatg aggaaactga ggctcagaga ggcggggtct cttgactgca ggctggttca
26221 tctcctcaat gcaccacaaa gttccttgat tggttcctgg catctggttt tgcttttctc
26281 ttccttgttt ttttttgggg gggggacgcg ggggatggag tctcgctctg tctcccagac
26341 tggagtgcat tggcgccatc tcggctcact gcaacctcct cctcttgagt tcaagcaatc
26401 cgcctgcctc agcctcctta gtagctaaga ttacaggcac ccaccaccat gcccagctaa
26461 tttttgtatt tttagtagag aaggggtttc actgtgttgt cctggctggt ctccaactac
26521 tgacctcagg tgatccaccc gcctcggcct cccaaagtgc caggattaca ggcctgagcc
26581 accgtgccca gcctcctttt atttttcttc acaaatcaat gacttttcca atacagaatt
26641 tggagtttca ttggaatgtc atcgttccct cagtgtatcc tggccccaag cagggctgac
26701 atttgtcaag tcctcctgct gtctgctgac atcatcacca tcacctttac cactgttcag
26761 acaaaaactt cagacaggaa cttgctccca aagcgagaaa ggagccagga gaccaaggaa
26821 tgactcgaat aagtccagct tggtgagtag gtgagtttat taggacttac acacagggca
26881 ctcagcagga tggctctaga gatccggcct cccccagtct ctaaactgct tttcagttaa
26941 ttttctgtct ctttgcctgc tgtatatgag taatgagact gtttttcttg gtaggttctc
27001 gcatactctc caggatgttt gggtttttag agacacctgg tcctcagctg gggacaatgg
27061 ccatggctca ttacctggcc ttcagggttc aagcagggga catatacccc taaataacct
27121 aaaggggatc catcacacta caaccaccac ctccaccgcc atcatcaaga agccactggc
27181 tgactgagat acacttccag gaggacaaga cagagtggat gctggaaaga cagggcaggg
27241 gaccatcacc agggaaagac ttcattcttg gaaggacatc gaaccggggg caggtcggta
27301 gtggagccgc tgtttcttct gctgtatcca aaagttctaa ctcttcggct ttctgcattt
27361 tcagctcttt cttttcctgg ccttctcatt gctggttcct gcacacctcc cctctattcc
27421 tccccccaat atattcgtta gtctaaagga aatttcttct tcctattccc cacactctcc
27481 agtcccctct cctcccttat tccaggctcc agcattcctg ccttctcctt ggtgcacttg
27541 ccatctgcat taacccctcc cctgctgtgc tcagctacag aaatgccaaa gtcactaaca
27601 ctcagctcca taaactttac cttgccctct ttatccccct aataaaatgc ctgcattttg
27661 tcgtggcctg tgtatggctc acctcccctg ctggctgcac tggtctgggg tcagtgggta
27721 tggcatggat tcagacgctg atagatctga gtgagctcca ttagattctc ctccagctcc
27781 tgagcctgcc gcctcagctc ctcagcagat gcagactttg ccccctcatg caagtgcttt
27841 gactcgtata caaggttgac cacatccagt gcaaggaaga tgcctgaagt ggtcgcactc
27901 aggatccggg ctcctctgct cactgcccgg gtggtgcctg caatcgttct ctctgcttga
27961 ccWccacttc cagctgagat tcgccaggtg gtcacaggga gtcgggccct ggctctggct
28021 tgcctgatgg cacggatttc actcccaatg gtttgtgtgg cttcgtaata attattaaga
28081 agggaaagta agttgggtgt gatgtcacgc ataacttcct taaatacctt caaKcggtca
28141 atgctggttg cagtcagcct gctggcttca gcttctgctg atgatgtgta tgagtgctcc
28201 acgatgctgg tggtgatccc agtcacagca gacgctgctc ccagccctac cccagctgca
28261 gtaagggcca gactcgtccc tgctgtaaat ggtgccaaaa caagaccagc aagggacatg
28321 atgccagagg cagcgccagt ggagctggac accacRttgg agatggtgca gcctctgtgg
28381 acctcttcaa taccatttgc aagggcacga agcttttcta tggactcctg gatcttcctc
28441 ttgacttggg gaaactcttt caaaaaccat tccctaaact gctcatcttt ctgctgcaca
28501 tattcgtcct caatagctgc atatgttcta agcttcttca gagcttcgta gagagcatct
28561 gcctcatccc tgtaccaata aaggacagat gattaagaaa ggcagcttac ttatctgtaa
28621 aatcagctca ataagatctg ttctacataa atcacagagc tattactatg agtcaaatgg
28681 aaataaagct ttaaatttta aatggaaaaa tttaaaataa tttttccaag gttaaacatg
28741 ttttgtatat catagatatg ccacagtact tattctgtat gggaataaaa aacttaaagt
28801 catcttcaga tgctctttag tggtaggtat tcgataaaga tggctcctca agcaagagag
28861 gtcaacatca tccctccaat agtgtgtgga gaggggaaat tttgtagatg aacaaagaga
28921 agtgggttcg gagcaaaaag accttcattc agaggatcat agaacagtga aggattaact
28981 ttattagaag agaggtcgtt cttttgtctt tgggccctgg gaagggatct ctggggccct
29041 ggaatgtcct gcctggtagg aacatctttg tttccctggt ggtttggcta cagcacagta
29101 tagcaatgtt atgggtgatg ggttttgggg ctattacgta tcttttctgc cttccaaagg
29161 aactgggaac taagggtgtt agacctcagg gaggggctgg ggactccatg tcagccatca
29221 ggacagcttg tgatccagcc ccagaaagag ctctgtacat tgaggcatag gttgagaaag
29281 actttctcct tggccaaact ccagtcaggc tgctctgagc cttttctcct ctaggcgctg
29341 accttccatg cccatcccgt gcttgctggg cctgtactgc cccagttcag caagaatccc
29401 ccaaggcagt tagggagggt cctccccact tgctgtctga gcattcttgc tgtctgatca
29461 cggtcttcac ccgctcctta cctgccttta gttgagcagc ttgttaggcc agtttagcag
29521 aaacccccca ttctggtgtc tccagtcaga actggtccat ctcccactcc tcaccctggt
29581 gttggctgtg actccccctc tgtctttact atattgggag ctgggctcag tctccctccc
29641 ctgtaacNca atcctgaata aaggcttcct gatctaatgt gattcacagg aatttttcct
29701 taactgggtg agcttctctg gttggcaaca ccccatgtgt tttgtcccac attcacacag
29761 gagaacacag cgtcctgagg acaacgaagc ttcacacctg aaaccctccc agactctgcc
29821 ctgtgtgtct cttccttagg ctgattttaa tctgtgttct ttccctgtga taaaccacaa
29881 tcgtgcaata acagttatca gtgagttacg taagtctttg tagtgaatta tcaaacctga 29941 gtgggggctt aagaaacacc ttcaaatctg caactggtgt cagaaRgaag ggtgccttca
30001 gacattgcat tttgactaac tctgagtcct taagctatca aataaaacct cagactggaa
30061 gagatcacct tgcctggcat gttctctctt ccaatgccac atgccctttg atcttctgac
30121 tgaaggccac tgggtccagc cactgccccc tttgactgaa aagtgaaagg cctggctatt
30181 agtcctggct gcacatgaac tctcaagcca cttgacKgcc tcctgacctg gcacctccaa
30241 gcttcagggt ctcactgtca catgtcRcca gccaaactaa tgccttagca ggtgacagct
30301 tcacctgtgt gcatRccaat gccatgtgca atttcatgga acctcttatg gactcatgag
30361 actttgaaaa tcatctctat aaatcactaa tgctgaaaag acctgcattt ggacaagatg
30421 atagagaaag tgtttttctc tttggttggg gacttgtgag tctcctgaga acccttcaaa
30481 ttacccagtt ggcagacact tgttccaact ctccaagctg gcccgaagaa acacttcctc
30541 tactctatgt agaacagaag agggtcccaa atggcagttc agaaYgcccc agttcccagg
30601 catgctgtca gggaaacagt cacccatggc ccactatgcc catcagtgat gggatcaaat
30661 cagggaggga agaaatatcc ctctcccact cactggtcct ctgcaagtcc atggccacgt
30721 tacMtttcat gccctcagtg cctccctctt ctcaccctac tcccagcctt ggtgcccgag
30781 ccttcctgct gctcctccaa cccaggccca cccctgcccc atcctgaccc ctggctctgc
30841 ccctgaaacg tctctctggg tctttggatg gcatcatgct acttggttcc ccacctYtga
30901 cctgctgttc attctcaggc tttaaccaca Ygcccatctg attgaactac tattagcatt
30961 ggagagatgg caggtcccag tctccaagac ataaaacaac agccccagag ctgtgcaggg
31021 acagagccaa gatccacccc cagctctgtc caactccatt ccagcctctc tgtgttctgK
31081 gtcagcagga ggatcctgct gtgtttgtgc agttcctcag aggtggaaga aaagggcccc
31141 ggacagcatc tccaggaaca cacattgatc aggtcaagat ttttctggct tttttcaaag
31201 aaagtcctgc tgggcatcca actctaagaa aaacacttgg tcgggYgcag cggctcatgc
31261 ctgtaatccc agcaccttgg gaggccgagg cgggaggatc acgaggtcag gagatcaaga
31321 ccatcctggc taacacgatg aaaccccgtc tgtactaaaa atacaaaaaa aaWtagccgg
31381 atgcggtggc cggagcctgt agtcccagct acttgggagg ctggggcagg agaatggcgt
31441 gaaaccggga ggcggaggtt gcRgtgRgcc gagatcatgc cactgcactc cagcctgggg
31501 gacaagcaag actctgtctc aaaaaaaaaa aaaaaagaaa aaaaaagaaa aaaaaagaaa
31561 aacacttttg gtcctggtct ctccccagca atctttttaa aaggtaacat taacggagca
31621 cctaccatgt gtcagtcatt atgctaaata ctttacatgc attagcttat ttttctcaca
31681 ataaagctca atggatgaag aaaggaaggc agaaagtagt caagtagctt gcaaagctcc
31741 catcaccagt agatggcaga actgaccctg cccttgtggg cttcctctcc cctcagcctg
31801 aggtcactca ctgccagcga aggacttgga ggaaatattc ctcctggact gctgagaggg
31861 acattctcaa gttcagcaga gggggctgcc tggaggaggt gtgcctgcca gagaaaacta
31921 gcccagggga gatcaggatg gcatagccgg ggcgccccat ggaggtaacc ccacggaggt
31981 tacctgggca attcagccgc agtcacgaat ctcttccagg cttcattgtt agtcagcagg
32041 atttgcagat gcactgggct gactctctcc cggaagtatt tggtggcctc ttcagtaaag
32101 cgtttctttt ctacttggaa acaaaaagca taagattgga agaaagtgtg ctacagccta
32161 aatggcattg agaataaggt ggttcgaKgt taatcctcct caaccagctg tcacatgggg
32221 tatttttgat ggaggcatca gtgctataga ctgagttgtg tgccctccaa attcatatac
32281 tgagaccYta aaccccagta actatatttg gagattgagc ctttaaggaa gtcattaatt
32341 taaagagagt cgtaagggta gggccctaat cctacaggac tggtgtctag ttaaaagaaa
32401 aaaaagaggc agaagatctc tctctctctc ctcaccccac cccgccctcg ctgtctctct
32461 tgccttccag ccctctctcc ctgtctctct ttctctctct ctctctctct ctcacacacW
32521 cacacacaca cacacacaca cacatacacc ccccacactg ggaaggccat gtgaggacac
32581 agccctgagg cagMctctgt aagccaggag cagagccctc cccagacatc aaccctgctg
32641 gcaccttcac cttggaMttt ttgcctccag aactgtRaga aaatacatca gttgttggag
32701 ccacccagcc tgtggcgttt tactaaggca tcctgagaag agtgattcac cagggaagtg
32761 ccaYggtgct ttgtggagga accRatctat ttcagctgag aatcaccaga aagtgagctt
32821 tccaccatgY tttctcccca tgtacgggaa atattccagt gatcgcttcc tYctgccatg
32881 tgcctattgt caaacgcttt acaccagtgt cttcaaaatc tgagtttcga cccatcagtg
32941 ggttatgaaa atagttcatt ttgtcaagag cagcatttta aaaagaaaag agcattgaaa
33001 atatcagagt gtattgaaca cagcaagagt gagtattctt ttgtaagata tttgaaatat
33061 atataatata tatatacata agggtgtata tatatatacc cttatgtaaa ttcctgggat
33121 Mtagatgtgt ttaggatggc agcattttca atctgtgtca atatgacaca gggtgcatat
33181 gctgtatcac tgaccactcc cacactggtc aacgctacaa atgtttcaac cttgtaatca
33241 aaggtacaaa tgtttcaaca gagaaaccaa tgaatattca ccttaaatgg gatacataat
33301 attatcagta caaagcatct tagtacacag caggattact gcccagaKga gttgccccaa
33361 aaatgtgtgg tttgcaggga tttgggaatt atggaactgc agagaaggga ctgggaagca
33421 gtatggattt atgtatgcac tgggacatga ggtaaaatcg tttcctgccg tggacacact
33481 tgcgaggcct cattctcatt tcacagaagg agaaattgag acccagacag cgaaagacac
33541 cacccaaccc agcaagcagg aagctcagga tttgactcaa ggccagcgtt cccttgccat
33601 tactttgaag actccatata ttttgaaaat gcctgtggtt cctgcattct ccactgtagt
33661 atacctgtgg gattttaaac attttattga aaaagaatat ttcaacccta caccattgaa
33721 taaactacca tgcacagagg attcctcctg ctgctcatgg gcgctctcag atgggcagtg
33781 gagggggttc tttaggcggg caggggagca agaccctcag cactgatccc tgtggccctt 33841 ctgtgttacc tctgtcctct gcaggctggt ctcaggggac atggctcccc actatcacct
33901 ctgaacccag ctggccgcgt tattaaacca cagatcatct tgtttcggag aSagagtttc
33961 ttccttgagc ctcccagcca agcccttctg aaggattccg gggttggctg gtaggtcccg
34021 gcttctaatc ttccctgccc tctcctcatc ttggacagga ctcagcagag cccagtttgc
34081 tgtccagggc ggctcctgag cagatgtgac ttggttgcca aggcaactca gtgaggggag
34141 aaaacaggcc ttagggaaat gaacacagtg ctgacttggg tgaSgggtat tttgctttta
34201 ttttttcctc cttcactgaa aggatgaagg aaaccagggt tggatggagg gaacctccag
34261 cactagatct gtgtatttat tgctggggtg ggagtaccag ggtgttaaag caaacttaaa
34321 atgaacacct gggcaaacaa aagcaaacag gccttcagaa Wggctgtaac cccccttaaa
34381 ctgccaacta tggggaactt aactggagtc gtttcagatg ggtgcttacg ttaggcacaa
34441 acaaaactta acttcggcca gtcatgagca gccagctgac agacgggtac acgactagga
34501 attttccaac aaggtaaacc aaaaaacata atttgacaac tgcaacaaat caaataatgt
34561 ccttattcca cttccatatt caccctataa atacctgcct ctgacacttt tccatcataa
34621 catgaaatgt ctttcatttt gatgtttccc acttcatgac ttgcttcttc ctcaaataaa
34681 gtcttcaaaa ttcgattgga cctcagattt ttctttgaca aggggtattt gagatcatgg
34741 gaatgaggcc ctgcctgagg cagtcatccc tggtaagcag gtgcttgtga tgggccgtgc
34801 agggcaggcg ccctggggga caaaaagggg cttccacctg gaatcaacag tggcaggtaa
34861 aggggatggg aaccaactct tagggaggcc ctactgtgtg gcaggcactg gctgggccag
34921 gtacccatgt actatttgat cctcatgacc acatggggaa atattatact cgcattccag
34981 gtgaggggag gtaagaagct ccaggtgaca cagagaagac gtggcRaagg ccagaatggg
35041 gctcagttca gtgggacgct gagtcactct tttcacaggg ccactcagag cagaggggct
35101 ggtgcagggc aagagctgga gggaggggac tggcctgtgc tggaaacacc ccagggtcag
35161 ctgggagcag agcgggaggt cagaggtcgg gRctgctggt caacctcctc tctcagccct
35221 ccgcacctcc tggaccctgc tctcccccta ctccccgacc ctgctgtttc cacttcccca
35281 aggctgtggt gccccacttg agtcgtttgc taggtgccag ggcagggagg aagtgggcac
35341 ctgggccatg ctcccctgag gagaggtcag gacatagatg cccccacaga cccttgggtc
35401 gggggactcc atgtggcctc ttttggggct cagggaagac tcatcggcct gcttgaccat
35461 ccgggttcct ctggggctca ctgagttgtg gaaacgccac cctccattct aggtgcgagt
35521 aggaaccagc cagggaagag gaagaagcaa gcctacctga gtccatggtg ccagcagcca
35581 ggtcactgag agactttccW tggagctctc cagtcactga cctgactgga agggttcgtt
35641 ttttttctta acccttgagg aggagaaagc aaattgtggg actgaatgtg agccacctgt
35701 ggacagaggg aggttggagg ggctggatct ctgcaatccc tttgcgtgtc agcaaatgcc
35761 aagaccaacc tagcccggtg ttttttaatc tcctgggccc cagccagctg gtatttagag
35821 aaattctact tgctccagct ccctctgccc tcactctcac accaaggcag ggtccttttg
35881 tcctgtaggg gtatgaagag aagataatca gaggaaggga tggacatctg ataatcacag
35941 aaactacaga gtctatacac cgaaatagag atgggaagga acgttctgac aatgacctgg
36001 gcctggcaac atgtgtgata actaattgat aaYagccagt gtgtactggg tgtctgtgat
36061 ctgcagggct cctcatatgt gcctcattcg atgatcacac acaggccagg agatgggtgc
36121 aaccgtggct cccattttga aacagaagaa acctcaaatg ttaagcaacc ttgccatgtt
36181 ttcacaatag gggtagagcc aggacttctg attcaaatcc catgtcttcc atgactgggc
36241 tccactccct taaatatata aaaatattga ctcatgcata catgcttaYt gtaaatgact
36301 cctcattcca aatctgtgtc ttgcactcta tgcccaagtg tctgtcttgg tgaattcact
36361 ggtgctgtgc tggacaccct ttgtccccct tgcttctgcc tgtatgtcct ggctgcaagt
36421 gatgcttctg cttcaacttc ccaagtagtt gtccctacag gtacatacca ccacgctagg
36481 cacattaaaa aaaaattttt tttagaaatg tggatcttgc tttgttgccc agagctggtc
36541 tccaactcct ggtttcaagc aatcctcctg cctgagcccc ccaaagtcct gcgattgcag
36601 gcatcagcca ctacaaccag cctaaataaa tgctgatctt tatacagaga aacactcttc
36661 acattctgct tgtgatgatc ttgccttggg aaatgagaaa aaagaaagca aatgttgatt
36721 atgtttaggc attgttctaa gaaggtagaa gaacatttat tgactatccc ttcaagatct
36781 gactacagtg ttagtcaagg cacttatagg tataataaca gtcaatgaga aataggggtg
36841 aacatttgtg gactcgactt tgcaccacta attgctctaa gatgttataa ataataactc
36901 acagtcctct tccaagagcc tattaagtgg gtaccatttg tatttccatt ttcagataag
36961 aaaactgaaa cagatgttca gcgacttgcc caatctcaga aatctactaa ggtgtaaaga
37021 ctgggttccc acccaaccag acggactcaa gaacacacac actgcctctg caccctctgc
37081 tgccaatgaa aatgtgaatg gaccagttgt ggtggctcac gccttaatcc cagcaatttg
37141 ggagaccgag gcaggtggat cacgaggtca ggagatcaag accatgctgg ccaacatagt
37201 gaaaccctgt ctctactaaa aatgcacaca cacacacaca cacaaattag ctgggcgtgg
37261 tggcgtgtgc ctgtaatccc agttacccgg gaggctgagg caggagaatc gcttgaaccc
37321 aggaggcaga agttgcagtg agccgagatt gggtcactgc actccaccct ggtgacagac
37381 tgggactctg tctcaaaaaa tatatacata tgaaaatttg aatgaggaaa acaggagatc
37441 agagacttca acagatattt ggaagacaga actggctgaa gaagtgacaa ctgaatagag
37501 aggggtaaag ggatctgcaa tccacagcaa caccaagagc acattcagcc aagaattgcc
37561 tgctaagcag agcctcagag aggggagaag ttcaccagcc ccacgaccca tacaggattc
37621 acagtagccg tgagtctaca ccaatggaaa aaattagaga cttcataact gcatctaaag
37681 gccccagaaa taatatcttt gtatcctgat gccaaggagt tctcatttca tcactctaca ι7741 gggaagactg ccagtggacc tgcccctttc tttaatatga atagatctag gatcagataa
,7801 agcagaaaga caaaaaatgg ggaaaaggtc aagataacaa gtaaaaaatg agtccagaag ι7861 aaatggatga ttgcgaaaat agaaaataat ttttaaaaac tcaaacccat gtcctcaggg
17921 acataaaaat gttttattca taaatgagaa cattatgtac tgaa aggaa caaagatgat
17981 ggaacaaaaa agacttcttg agaattaaaa ggtgattgag aaaataaaca actctaggac
!8041 aagattcaaa aagataggca aggaagcttt ccagaaaatc aactaaaagg atgacagaaa
18101 aagaaaaaaa caaaaacaaa aacagagcta gatatagaat aagaaagtta ccatacataa
18161 taattacata gaaagctact tgagtctgag catggtggct catgcctata accccatact
18221 ttgggagggt aagcaggaga attctttgag tccaggagtt ctagaccagt atgggccaca
18281 tagtgacacc ccatcattac aaagaataca aaaatgaacc aggtgtggtg atgcatgcct
18341 ctagtcccaa ctactctgga agctgactgg ggagaatctc ttgagcccaa gaggtcacag
18401 agcaagaccc tgtctctgtt aaaagaaaaa caagtaaata acagaaaaga aagttacttg
18461 agaatgagct gtggaggctg agaggaggaa gaatgtgagt gtgtgtgtgt gtgtgcacgc
18521 acactcatgg agaggggata aggaaaacca agagagaaaa agacgtgaaa gagaaaaatc
18581 aacccaggga gaaggaaatg caaggatcac agctgggcat gcagcaggcc tagaaagcaa
58641 ccagtccagg atagaataag aaggaaaggg ctctgtaggg aaaggggact cgatagaaca
58701 ttgcatataa ttcacagttt gagaaaaact gaggaaatca tgaaggcaaa cagtacaaga
58761 gggggaaaaa acaaaggcaa ttagaaacat caggaaaaac taaagccgtg cagcaaaaca
38821 tgtgcaacca tattgtacaa ctcagctcaa cagtaagcaa gatttaaaRc gtcaccaaaa
38881 tgtaaacact tggttaactt ttaactttta gaacaaaaca gaaσatttac atatgagaac
38941 taaatctact tgttaccagt cagtataatt aatgttccat ggtaaaggtg ggaggtgaaa
39001 cactgaagga aggaggggga ggattaatat ggccattttg taaagtgaag agtcaagaaa
39061 tactggctac agttaagggc ataagaaata aagttaaata aactcacgtt tagttctcac
39121 aacaaccatc ctacgtaggc actgttatca tcttaatagt tctgagggga aaactaaagc
39181 ttggagaagt taagtaattc acctggagcc cctagctagt gacagccaga agccaaactc
39241 aagtgcccaa tctccagagc atgcactctc actctatttc atctgctagc ataagaatat
39301 tatgtaaaga aaatgattta ctccctaaag aaaagctggc taggcacact ggttcacatc
39361 tgtaatccca gcactttagg aagctgaggt gggtggatca cctgjaggttg ggagttcgag
39421 agcagcctga ccaacatgga gcaactctgt ctctactaaa aaaatgaaaa aattagccgg 39481 gcatggtggt gcatgcctgt tatctcagct actcaggagg ctgaggcagg agaatcgctt 39541 gaacccagga ggtggagttt gtggtgagcc aagatagcta cattgcactc cagcctgggc 39601 aacaagagtg aaattctgtc tcagaaaaWa aaaaaaggaa aatctgaaca tcaaaattag 39661 ctgcttttaa ttgggaaggg agtgagtgga gccctcttta ttaaatgatt tgtctgaacc 39721 gtatacactt attaattgat ttttttaaat tttaacaaaa cagaagttac tttatagtag 39781 ttagtaactg ctaacctcaa taatggtttg gattgtggtg ccaccacctt aaagttgatg 39841 gagaagtgtg agcaagtgcc aaagagaaat acacctgcct cctgatggga gaaatgtcag 39901 cttcagagaa acctcggtgg ctggggtaac caagctgcta agaaaagtac ggatgttgtc 39961 attttatgtt aaactgttaa tattaacagc ataatcagag tgaactccta tcttgaatca 40021 gtataatttc cagtggcacc ttgccactca acatacgggc ttcttttcca cccaaaggaa 40081 ccaagacgtc ttgtggggaa ccaaattccc cagactgtga tatgtgttac cccagaaagc 40141 aaggacgctt ccaaagatgt tcagagcagt gttcaaaggg atgcccactg gtcagtccca 40201 accgctgtga acccggaaaa tctgagactg gtgtcagtta atttagaaag tttattttgc 40261 caaggttgag gacgtatgcc tgtgacacag cctcaggaag tcctgatgac atgtgcccaa
40321 ggtggttggg gtgtagcttg attttataca cttagggagc atgagacatc aattaagtac 40381 acttgagaaa tacatcggtt tggtctagaa aggcgggaca actcaaagtg ggcgtttcca 40441 ggctacaggt aaattgaaac gttttctggt tgacaattgg ttgagtttgt ctaaagaccg 40501 gagatcaata ggaaggaatg tttgagttgY gataagaggt tgtggagacc aaagttttat 40561 cctgcagatg aagctttcag ctagcaggct tcacagagaa acaggctgta aaatgtttct 40621 tattagactg aaagcctgtg ttgatattaa tgccagagag gcataatgaa gcatgtctga 40681 cccccatttc ccttcatggc ctgaaccagt ctttcaggtt aaattttaag agccctggct 40741 gaggaggaag tcctttaaat gagggggagg cttagaatct tacttttggt ttataccgct 40801 tatattcaac agtaataatt gattgtgatt attatgatca tgtttacttg gtccaagatg 40861 aatctgtgaa aggccttggg ttgatactaa cattcaagtg agaacatttg agaaaagtat 40921 acagaaaagg ctaaaacagg gtacttgaaa tgcaaagact tatcgtaaca gagaatgttt 40981 aattgttaat tggttttaac aagaagagca tcttaatata aatggatatt tttccttcta 41041 tttatttatg ttcctgttcg taagtgttga gaatgaagga agagctgcca cagacatttg 41101 gaagctggcg tggactccca gaagggctgt gttattctcc tatggacaga aataatgtca 41161 cagaatagta accacacaca gggtgactct gagattgtga gcaaatgaga cagagcaatt 41221 agacttcata atactgtcta agtatagaca gaaactgagt ctctgctcca cccacaaaat 41281 accaaacact ccctctcctg gctaaataga atgcctgttt tttctacacc aagtcaactc 41341 taacctcttc ctggtctccc tctctctaga tgagatttgc tgagataccc actggtagac 41401 ttgcccccca ctttctgcaa cacccaatcc agagtgggct ccatttcata ggccctcctg 41461 ccaatcaccc agccagaacc cagatattct aacaggttcc ttctcgcacc ccttatggag 41521 gtgccgatgg acctccacct gtgtccccct cactgagaag aatgaactca actggttcaa 41581 ccacctacag gagtgatctg gcagccccag cctggaaaca Ytgactctag agacttccat 41641 ggtttctgta gtgaggaggc aacaacaagc ccaggcagct gtgaggtggc cctgtcaggc
41701 ccctcaaagg taggggttgg ctccaagcag gcccctatct ctttcttctt tactgtggct
41761 tcggctgcat ctgtttcagc tggctcccag gcacatccat tccagccgct ggtctttgct
41821 cccagacttt atgttaacaa cgcagtggtt cccgggaccc cctgatgcgt tttcatcctc
41881 aaggtcatgt gtagaagcat cctcatcgaa agcctctcac ctccctcttc ctatttcctg
41941 cctctgtctt agggatcttg catccaggtg tctattgtct ggggccccca tgcaaccatg
42001 gtgacagtga ggccaataga ggcactaggg gagtgtgctg aggggtttct gggtgcttct
42061 tgctgtaagg gataagggtg atagaaggag ggctcccctt ccccttcttc ctgctttgtt
42121 cagtgtgtga ccccctaggc cagggcagct gtctcaacat catgagccat aaggaccagg
42181 agccagcaca gagcagagga gcaggagggc agagagagct ggggcctcag accacacctg
42241 acacctctga tgagctacac ccagggtctc gtcctcctta ggcgttgttg gcctggctcg
42301 gaatcttgtc tggggcatcc gctgagggtt gaagctggat actgcccctc gagctgaact
42361 aggacacagc atgtcctcYc tgggcaagcc tgcagtttgg tcaattcccg gaaagggact
42421 ttagttcctg gaggaggccc agacagggag ccctccctcc tgcctcagct ctgagccaag
42481 ctctccagat gcagaggaca gagactctca gcaaagcagc tccctgcaag tggctgtggg
42541 gcctcctcct taggcagaga gagagggaga gaggggtgaa gacaccgtgc tcctcctgag
42601 gaatctttat ttttattttc aatatttttt ttttttgctc tgttacccag gctggaacgc
42661 agtggcacca ccataactca ctgtagtgtt gacgttctag gatcaatcga tcctcctgcc
42721 tcatccttct gagtagtggg aactacaagt gcatcactat gtcagtcaat ctttttattt
42781 tcatttttgc agagatgggg tYgtgctatg ctgcccaggc ttgtcctgaa ctcctgggtt
42841 cgagggatcc tcctgcatta gcctYcgtgc attagcacgg gaattacagc cctgagccac
42901 aatacctagg tctcctgagg aatctttaat gacctgccag ggtcaagttc aaccccttaa
42961 ctgggcacac gggctcctac tttcctcact gctccctgσc cacacagtca ccttgggtcc
43021 aggtacacac tgacgccctg cttccctgcc tcccagagcc catctactcc ccccactccc
43081 attcccagcc tcaggccttt gctcaggctg ctccctcccc ttggaatgcc tcccccacct
43141 tccccaccat gtgcaagtca cccatcctca gaggctcagc caaagctgcc tggaccctgc
43201 agcgtccccc agccctcccc aggctccctg agcactctgc tttccggggg cagctctacc
43261 tctgtgtggc tctttgggcc tctgtctccc cgttaaactc tgagcatccg gcagggaccc
43321 tgcggtgttc ccagctgcat cccctatgac tgacctgggt ggcctctgcc ctccgtggca
43381 cagcctggct gaaatccgag gtgtgggagg cagcacttgg actaaaagca accagcctct
43441 ggacaacatg gcccagcttc agtttcactt tcagttgagg gattgaatgt ttttccttgc
43501 tatctagatg ctcatctctt tttggggaag aacaaataag accatgactc tgatttcatg
43561 tacttttggt ggctctatca ggtttctgag tttccattta ttttctcccg tgtcctcccc
43621 agtcttatta cttttgtacg aggRgaaaga aaaaagaaat ttctaaaaac acgcgagcca
43681 gctaacctct gaatcatagc catggtttcc aagcctcccc tcccccacgg caatggccca
43741 ggcctgcatc tgggcccagc tccctccggg tccatgacac tcttatgcag caaccaacta
43801 ctgccaggga cttttacggg aaagaggtca tttccttcct gcacttgttg tgccttagaa
43861 tacacacaaa aaagtcttgt tcttctttgt ctgtagtagg tacccatgaa ataggtccta
43921 catttaaaag aagaagaaac aaattcttct ccaaaaataa gtaaatcaat cccaaaggga
43981 tctaagtgta ccccagaaag aaaaaattaa aactatacta gaagaaatgt taaaaacaat
44041 gttgagttgg gaagaccttt cgaatcaaaa ctcaattccc agaagactta aagggaaaat
44101 tgaatagagt tttacctctt acaaattaaa aattagaaag aacatcattc aagagccaga
44161 ataaaatgaa agaataggaa gcacggtttg caatacttaa agcaaaggta actgtccaca
44221 atccacaaga aatgctcaaa tcaacatgaa aagactgaaa tcaagtttct aaaaatatag
44281 ccaggtgcgg tggctcatac ctgtaatccc agcactttgg caggccaagg cgggtggatc
44341 acctgaggtc aggagttcga gaccagcctg accaatatgg tgaaactctg actctactaa
44401 aaatatcaaa atttgccagg tgtggaggca cgcgcctgta gtcctagcta cttgggaggc
44461 tgagacagga gaattgcttg aaccccggag gtggaggttg cagtgagctg agattgcgcc
44521 actgcacttc agcctgggca acaaagccag actccatctc ataaataaat aaataaataa
44581 ataaaattta aaaatgggta aaagatagga tctgaagaaa tagaaattaa cgttaaccat
44641 atgaaaaggc actcaagctc acttttgaac catatatgta agtgatcaca gagacatacg
44701 tttttgaaac attagataag ccaaacctaa agtgactaat aatgtccact gttagggagg
44761 taaaggtggc acaagcccct tcactgttga tggagtgtga aaggttctgg tgtcctggag
44821 gatcgtcagc gatactcagc acactttaca aagtgccccc acgtcatggc acagcaccca
44881 ctcctaggtc tcagcctcca gggagcagag ggcaagtgtg cagggacagg ggctttagag
44941 ggtgccatgc agcgttgttt ctatcaccaa aaagggagaa atcactaaat ctcctgccat
45001 agggagtagg cgggtcccta acactatgcc cattaagact aaggaatgcg Yctggcacgg
45061 tggctcatgc ctgtaatccc agcactttgg gtggcggagg tgggtggatc acaaggtcag
45121 gagatcgaga acatcctggc taacatggtg aaaccccgtc tctactaaaa atactaaaaa
45181 ttagccgggc gtggtggcac gcctctgtag tcccagctac tcaggagggt gagctggaga
45241 atcacttgaa cccaggaggc ggagggtgca gtgagccgat ggtgctactt gcactccagc
45301 ctgggcgaca gagcaagact ccgtcagaaa aaaaagacta atgaatgcga tgcctccctt
45361 aaagaaatga ggaggaaaag aagctgcaca gaatcaaaga cccttcgagg ccacgacaca
45421 gaggtgagaa acacagggct ccatgaagtg aaatctgaat agcaggtgtg agtgtgcgtg
45481 tgtgtgtgtg tgtgtgtgtg tgaatttgtg agtgtgtgtg tggcatatgc aaggtttgcc 45541 ttttatttgg ttgccagcat gtcaaatgta attgcacctg agtttatagc aaatgttccg
45601 tcatctgagc tctgaggagc caggcccacc ctctcacctg ctgggcatca cctggatctg
45661 agaagcccat gcaggcctcc agctctcccc actttcctgc agcccctgca ggcatctggg
45721 ctgcaatgtc aactttcccc tgactcgcac tgccccgcct cccacctcac cccagatggg
45781 gtcagcagcc tgctgggggt cagcagggta gggcatccta accccctMWg gcaggtgaaa
45841 aaccctgagg ctcagagagg ggaagtgact tccccagtgt cacacacctc ttggagggca
45901 gggggaaggt caacacctga cctcctgact ctgacattga agcaagaaag tataatgtta
45961 ataatccaaa atcttccagg tttgtttctg cttctacaaa cacagagggc taagctcacg
46021 ctcccacagt tatgctcacg cttccacagt ttgactttta atctcatgat tgtcaagctg
46081 ggatcatgtg gcagacacca ttctgcaaca tgccgttctc actgcccctg tctgggccat
46141 ctttcccact agggaacagc acagcttctt tcttctctat cacccagagg cctgaaaagg
46201 aaccaggtga gtgtcaggga catggagtcc tgtgatctac ctgctcaact tcctgaYatg
46261 ggaccctcag cgagtcactc atctcccatg gcctcagttt acccacaggg cctggctcaa
46321 gtaggtgctc agagtcaggg tgggtgaaac aacctctggg ttccttgtta tctcttttcg
46381 ctctctctct cttttttttt tttgagacag agtctcactc tgtcaggagt gcactcaggc
46441 tggagtgact ggtgcgatct cgactcactg caaccttcat cacctgggtt caagtgattc
46501 tcatgcctca gcctcccaag tagctgggat tactggcttg tgccaccacg cccagctaat
46561 tttttgtatt tttagtagag gcagggtttc tccatattgg ccaggcaggt ctcgaactcc
46621 taacctcaag tgatctaccc gtctcggcct ctcaaagtgc tgggattaca ggcatgagcc
46681 accgcgccca gccaggttcc ttgtatctca aaggaaatcc tctgtcccca tcgggcctca
46741 gcagcagcac cctggggcca gcctcagggt ggccaggcca caagaaggac aggccaggct
46801 ctggatcacc tcctgtcctc caccttctct ggttcctcca aatattctaa aggaatggac
46861 agtcccaaca tctgccttcc ttctggggtc accgggccat gtctcacgca ggctggaact
46921 agagctgagc cctaggaagc tttgtgaacc cagctgagct gattctgcct ctgtctctac
46981 tgtttggggg cccagagaga gggagggaga agtccagcta aaacctgggt gcaaattcag
47041 gctctgccat ggaccgagat gtgacctcag tcagttacct aacctctctg agctcatcta
47101 caaaaggtga atgacccttc tcttatagag ctgctgtgag gatggggaga tggggaaggt
47161 cagaccaccc ctaacttacc aaggaagctt ctcttgaaag agtgtgagca agatccagct
47221 gttctgagct gtgtggatcc cacctccagc cgtgcatctg cataataacc agacacgttc
47281 tccagKctct gagatatacc ctggaaccca aaagggaaag tgaaagtcac aacttggcag
47341 cagctcctga tcaaacatgc aaaacaggat gcttcccagc cccacccttg gcccagtccc
47401 atccttggtc cagcagcacc cttggtYcca ccctcctgct gatccaagag cagccccaga
47461 cgtccttctt ggccaaccca cctgcctccc atacttaggg ttgggggttt gctgtgtctt
47521 caggaagaaa gacctaccac tgaaagacta tgagaccctc cagattactc cccaccccca
47581 ataacaccac actccccaga tgcccacctc actccctcca tgccatcagc attaccacag
47641 tccatcacac atgccgggtg gacgcttatt gcatattgat tgtattgctg ttggggttat
47701 tttgttgttt tgttttgttt tgtttttgag atggggtctg gctctgtcac ccaggctgga
47761 gtgcggtggc acaataatag ctcactgtag cctcaaattc cagggttcaa atgaacctcc
47821 tgagtagctg ggactacaag catgagccac tcggcctggc tacttttaaa aaatgatttt
47881 gaaggggtga aatcttacta tttttaccag gttggtttca aactctggcc tcaaatgatc
47941 ctcctgcctc agcatgagcc acYgttccag acctgctctt gtcgaacgcc atacctgtgt
48001 ggcttctgga caYttcctta tgtgggttct tctgccagga gcacctgcta ccttcacctg
48061 gaaaagtcac gctcctctat cagaatgcaa atctagcatt tcctcccctg agaagccccc
48121 tagcatcctc ttcagcagag cccactgccc catgttccac tcctgtggca cttttgttag
48181 gctgttgtaa ttggccacag tcccaggttg actgaacaaa gtggggggYg gatgtgggag
48241 taaaagacaa agacaaaaga gtatattagg aagaaggggt cNgggggttc cttgcttcta
48301 gtgaacaagg gctctgagct tttcaagctc tctgagttta ttaggtaaaa gagatgacga
48361 gaaaaaggtg gggggNtgat tgtcaggtaa ttgtcagtca gccRtttggt tcacagcagg
48421 cttgcaagac tgcatccttc aaataatagg tgctagatat cccaacagat aacttcaagg
48481 agcccagcac cagggagtga tggccctcag gaaaccttct ggcggcgggt gcagtgtgag
48541 tttacccaca tcccgcattc atgataaaca gtttgctgtt tgatcatata gcctccagtg
48601 aaatgctgag ttggtcacaa tccctttggc cttttcagct cccaacaggc agttaagtag
48661 acattagcag ctgggaggag aaaagagagc agaaagcctg tcactgcaac agctcctggc
48721 ccacctaagt tcagccccag agccattcta agacccccct aactgatgaa gttggtggta
48781 tagtttgtgg ccagcacatc ctgaagaaag agaaactagg gcacaggtgg aaattcccta
48841 aaggggcaca tgcccagtaa catgaaactg tgccctcagg tcaccccaag ttcattatac
48901 catcattata ataaaatgtg gttttattat acaaaagccc cagagtgggc ttttctgtga
48961 aaattatggg taaaaacatg cattgcctaa ttttagttat ataaccataa actgccaatc
49021 agatgacatc gtcctttact cagacacagc cccaacctca acttctctcc acaaaccgca
49081 cagaagcacc ttaaactcta tatagagggg ctgacttcac ttcacagaaa ttagcccact
49141 gtccctctga gagtgtctaa ctgtgcttca atacactttg ctttgagctt gcattttgga
49201 gttagcctgc aattgtttgc tcactctcag aagaactgag attactggtc cagaactcca
49261 gctctgttaa tctcctcagt taaaggatcc atcccagcgc agaattcctg gtaatatctt
49321 agtgctgtga cctggatgat ttacgttcag catggctttt aatatgtgct tgattttagc
49381 ttggggaact gaaacatatt ttgctaaaat gcttcctttc gctttgggtc aagatgtttg 49441 tgctatgttt cgσtgcttgg ctaagagaag ttgcaatgag tgttgtattt gctgcattag
49501 agagggggta tatcccccaa catgccacca ataactttta gagaagggct tagagaaatc
49561 ttctctggat ttaggtttaa ttagctgttt aacgtgatta aacaacttca ttaggttgta
49621 gtggccattg aagcccagag cttgttaaca gcccagggaa gctttgagag gcaaaatggt
49681 ttcttatgct ctggccacag agccaggaat caccctcaac tccctttaga ctgggcattt
49741 tggctggatg caatttttaa aattactgat taagagagcc gattgggatt cagatcatgg
49801 gatagcttgg ataaatgcta agtttagagg tttacagccg ggaacgaagg gtaggcccat
49861 agtgggtcat aacctttgga gaactcccca aatcgtcctY gcccaccctt ttgggcactc
49921 accccacccg aggccccctc cctgccacac tgccataggc agcagcacag cttctgaaga
49981 tcgttttgca attttttttc ctttttcttt tgaacagagc ttcatttctt ttctttcttt
50O41 ctaaccactt ttattcagaa tctaggggac aaatgttttc agcaaggctg tagtacccac
50101 tgtaggaagg ggtctccatg ctgggcacag ccatggtcca cacataggta caacttgaga
50161 gacacacaga ctgccccagg ggaggcggag cctccatcta aagagcaggg gacactctct
50221 cctggtaatg gtcaaggata ttgggatgtc gagactacct tgatctcagt gctgtgtatt
50281 ctggattgcc agctgcatcc acactcctat gtaaaaccac agagggctgc ccaaactgat
50341 gatgtctcca cagacaaata cacttgtgag actttagtgg acctcaagcc tctctttaaa
50401 agactgccaa aaaataagta atgcccactg actttcccta gtgccttttt ttaaatatta
50461 gctttaagtt ggattgttat agttattctc atatatttgc agttcaattg cctcctcctg
50521 aatgggtgaa ataatttttt atgctaaaat agctgtttta aatgcagtaa ccaatatttt
50581 tgctttttaa actagattaa cccttgcaat catttctcct aatgtttttt tccaacaccc
50641 atatttagct accatcaaag aagttttaaa accttgttta aacacaacat caacggactg
50701 cacaacatca cagaaactgt tgaatctgtg tttacacctt ccctagcaga ggtctatcag
50761 ccatttccat tcctgcttct gagtggaatc aatcagaaac atttccagcc cccacttctg
50821 ttaaccgacc agaataagct gtcaatccta gggtcgagcc cacagtcaat tgcatactcc
50881 ttaaaagtct ataccaacaa acctgttaca acctccgagg acctgtcgtc tatctgtaat
50941 actatctgac taagcactcc tttgtcttct atcttcattg aggatgaggc cattacttgg
51001 attttttcct aatatttcca aggcttgcaa tcacacttgt accctatttt ccacccaatt
51061 atgtgtcagc ttagtcactg acaacaaaaa atgcaaacat acctgatatt ctaattcttc
51121 tttgtgtttt attcatttcc caagcccccc aacagaacca ctatgtggaa agaagccagc
51181 tattctggat ctaccctttt ccccagaccc acaccagaat atcattttaa acataacaac
51241 ttctggtttc agtctcacaa cttcgggcaa aatcattgca aaaaactgca gctccccata
51301 atttcacaat attggttggg atcccatcac tccttcctct aattgggctt ttgattcctc
51361 tttcattctg tcaagtactg cctgtgttcc cccattacat gaactagcct tgacttccac
51421 ttctgagggt attaaagcag acttacacag catggaaaaa ccctacttta gtatcactgt
51481 tgatatttgt cttaacatga caaatcacat ttttgtatag aaacaaggca tatctctgct
51541 tgtctgctaa ttaaacgggg atttggccct agtttacatc atccccaaac tcactcttat
51601 cgatagcatt cccctcccta tacacgctca atctggtaaa actgaaagag gagttttaac
51661 agcactgact ataattggcg ttctggctgg tattggcacg ggaactggag gacctcctta
51721 actccatttt tactgcccag aaactcttct taaaaattac tcaacaaatt attaatctaa
51781 ctaaccaggt caataccctt tcagaacaaa ttgcttcatt agcaagcata gtcttatgaa
51841 attgatgagc ttttaatttg ctcacagcca atcaaggggg agcttgtgca acacttgata
51901 aacattgctg ttttcatcaa ccaatcaggt aaagtgcaaa ccaacttaaa aaaattacag
51961 acagggccaa caagttaatg gaaaacagag tttcaggagg ctttgactgg tggaaattta
52021 acaactggtc ctggttttcc tggttagccc cctttcttgg tcctaaaaca gctttataca
52081 acttatagct ttcaaacgat gctcatttga tttacaaggt tgttttgttt cttcccacct
52141 agaatccata aaactccaaa tgattctaca caaggttacc gcgaggtctc aaccatgtct
52201 gatatctacg tgggcccctt ggatggccac cacttttctc tgcccaacct accagctaca
52261 agagagcaaa aaagagaacc caattattac cactgcctct tgtcagcagg aagtagccag
52321 attaattgtc accgatctac ccaaaaattt ggcttttttt ctctaaaggg ggaaatatta
52381 ggtagttaaa tagacattag cagctaggag tgggtaagaa aagagagtag aaaggctgac
52441 agtgaaacag cccctggccc acctaagttt agccccagaa ccgtcctaat gccatcctaa
52501 tggatggagt ttttggtaaa gtctgtggcc agcacatccc aaagaaagag aaagtaaggc
52561 acaggtggaa gtctcctaaa ggggcacatg cccagtaaca caaaaacatg ccctcaggtc
52621 accccaagtt cattatacca tcattataat aaaatttaca tgtggttgta ccctcctttc
52681 cccagagtgg gcttttctKt ataaatgatg ggtaaaacca tgccagttta attttagtta
52741 tataaccata aactgccaat caaatgacat catcctgtta ctcagacaca acccaaacct
52801 tgactcctcc ccacaaaccc cataaaagca ccttaaaccc tgtaaagagg ggcttatttc
52861 acttcgcaga aatcattccg ctctccctct gagagtRtat tactgtgctt caatacactt
52921 tgccttgagc ttgcattttg gtgttagtct gcaattcttc gctcactatc agaggaactg
52981 agattgctgg tccagagctc cagctctgtt aatccccacc tctgttaaga atccatccca
53041 gtgcaggatt attggtaaca cttagaggga aggggcctaa gcccactgct cagccacagt
53101 cccgtggcta agaaggcgtg ctgtcggatt gctggcggac ttttctgctt taccccaggc
53161 agaagggttt tgagaggggc tgaaccctga ccaacatgac cctttcactg ggaactgttt
53221 catcctgggc aaatgtccct gcagcctcgt ggccaccacc ccatacacct gccagatttt
53281 cagggaggaa caggagggtg attacacaag aactgtacga tacactttga aatataccca 53341 cttctctatt taattggaat ttgataacca tctcttaaat gggccaggag tatgatctga
53401 gt tacaggt gagRaaactg aggcaaggca tgaggctgtg gctttcaacc agcaactcgg
53461 ggaggagcca agatttgtaa accaagWtgc gtctgagaca gatctcaatc cgtttagtgg
53521 tttattttgt catggttgag gatgcccaca ggaaaaaaaa aagagacaca agtcacagtc
53581 ggatctgtgg cccacaagtt ttcaaaagag ggttttaagg gcttcaatat ttcaaaggta
53641 aagagtggga aggaggagga gggatgaaaa aaaaagacag gacaggtagt gagaagagtt
53701 gtcacattct tgtgaggctt tgattagcac ttcctgaatc tatgtgctgc atgtaaaagg
53761 catggataga agaacagtaa ttatgcattc atctcatgct cagtaaatgt gtattttaca
53821 gaagataaaa ataaacaggc agggcttggt ggctcatgcc tgtaatccca gcactttggg
53881 aggcctaggc acttggatca cctggagtca ggaggtcgtg accaacctgg ccaacatggc
53941 aaaacctcgg gtctactaaa aatacaaaaa gtagctgggc atggtggtgc acgcctgtag
54001 tttcagctac tcaggaggct gaggcaggag aatcgcttga atccaggagg tggaggttgc
54061 agtgagccgg gatcatgcca ctgcaatcca gcctgggcta gagagggaga cKccatctca
54121 aaacaaaaca aaacaacaac aataaaatga acatagatta gaggaagcag tcacatatgc
54181 atttgtgttg aagtgagcag cagggtaatt tctagtcttg gttttgtcat gtacctgtca
54241 aggtaagtta ctaatttgca ttgtcatggt aaaattccac aggctctgtt ttaagggaaa
54301 agatgttggg gctcacaagg aattttcttg tgggaaatcc atgaggaaga ccacctgggg
54361 aatatgttgc cttctgtctt ggcagatacc tgtttaggga caaaaagaag ggcagttttt
54421 tgactgattc aatttccctg cttaacggtt ttctttggca tagagagttt ggggccctga
54481 tattttattt tcctttgaca ttatctctcc cttttacaaa atctttttga gaaagcattg
54541 gagatgcaaa tgagtctctg gtcatgagtt tcatctgatt cctgtcagat gaagttgtct
54601 agtttcagtc tgtagggtgt tcagggaagc acggttttaa tttctggtga ttccgagtga
54661 gaaaaatgag agaaagaaga caagaatgat gcttcttttg agacttgcag ccaagaaaga
54721 attcacgagc cagcctagat gaattttgga caaataataa aactggaata caatggacaa
54781 agctagaatc taataacagg tattctacag tttcttttaa aacatatttt tttttctctt
54841 cagtcctcta attctaccaa agacaaatca tggtaggact aatttatttg aaaaataagt
54901 tgtagtctta tgatacttgg cctgattact ttcataaagt gcagtaagaa caatgattta
54961 ccatatgggt tcttcttaag aaattggatt tgctggaaca tcttcttttt cataaggaat
55021 ctcagattac accttttaaa gccttgagtt cagccaagta tttatctgtg cctgcaggtt
55081 tctgtatgaa ttgggtgagt tcctctcttc ttgagattcc aagataactt gggggttcct
55141 aggcctgtca gaaagtatta ttttccttac ttaccccaca tcccacatca ggaaccctgc
55201 atagttaaag aatgaggcca attttttgat ggggctttca ttggctctat aagtcaacct
55261 ctattcctca aagctgcctg ctcatatgtg aaaatatgcc atgccagtca aagccttgat
55321 aaaataacta gtgtctccaa tggtgtccta ttgcaaagga aaacagattg ttactgaact
55381 tatgcaaata attctattgc cataaattaa gaaaactcac aaatagtttc caaattctgg
55441 agaaatcaaa tagagagaaa gaaatgtgct ttaacttttg ctcacaagag tRtatttcat
55501 tcaactgtca aaagctgtac atagctcaca agatatcaac gtttccttga ctctgaagaa
55561 gaaaaaaaaa agaatcagcc atgtttcaaa cacaaagtca tctaaaaaat tatttcagtc
55621 ctctattaga tcagtcctaa gatagaaaaa aaatcaaaaa tgttattttg gagacttgcc
55681 gccaggaaag atttcaggat ccattctaga taaattttgg acaaataaca aaactggaaa
55741 aacaatgcac aaggccctaa tctagtaaca ggtgttctat aactcgttcc acctgatatt
55801 gggttagcaa tcctcatgaa cataacaact ttttaattag agtcctggat tttttttctc
55861 tag ccaatg gcatagcctg tagctgacca taaactggta ttgagaagaa ttaaagtaaa
55921 acagtaactg tggatagcaa aagtattaga gcagccttgg caaacacaaa attgacaagg
55981 aaatttggtt atttctgtga cacacaacaa cttaccgtaa aaatgattat tattactaat
56041 aacatatatt gctgtgtgcg gtggctcaaa cttgtaatcc cagcactttg cgaggctgag
56101 gtgggcggat cacttgaggc caacagtttg aaaccagctg accaacatgg caaaatccca
56161 tctctactaa aaatacaaaa agcagcttgg tgtggtggtg cacacctgta gtcccagcta
56221 ctcgggaggc tgaggcatga gaattgcttg aacctaaaag gtggcggttg cagtgagcca
56281 agat tgtgcc attgcactcc agcctgggtg actgagtgag actctgtctc aaaacaaaca
56341 aacaaacaaa acaaaaacac catagaggaa gctataacag aattataggc atctcataca
56401 attttggaac acatttattt atatataact caaagaaagt tacaacacca ttttacatct
56461 gtcctgctag acccgtgcta gacacttgca agctcggaga gcacagtctt ggagagagta
56521 aagaaaagac ttggagagag cagatgagac ataagcttta ttcagggaac ttacatacaa
56581 ggagtccagg agcagcaggc tggacagaaa gcccctcaca tttgtaaaaa gcatgcagtt
56641 tatatagtat ccttcccaca gcaacctcca cttagccacc tccacccggc aacctccact
56701 tagcccaaaa caaagggcct tggttccctc caggacctgc ttcccaagga ctgggccagg
56761 ttacaggtgt tcttcatagg tatagtgtaa acatctggat tggccattcc tggggtccat
56821 agtttagaac aatgaacaaa cattcaccaa ggaacatagg gccattctca ggggatgctt
56881 gaa tattgc tgtctgacag gacatgccca ctaggcactc cactccagta tagccttcag
56941 tggccctctc gtaccaagta agatgaatat gtctcttcaa gacttcaggg gacctaatat
57001 ctaaaaaatt aatgaggtca aaacactgga tttgaaattt gattttagaa agtttgtcaa
57061 ataccaaagg ttgaaaacac ttgatatcac aaaataggat tacgctcact ataaagtaag
57121 tcattcgtgt ggccaaagag ataacttaaa tatttcaaaa acatagaaat gtttacacct
57181 tgagagagag aagactcagt ttcccacaca ataacacctc ataaagacag catgggccgg 57241 gcatggcagc tcatgactgt aatcccagca ctatgggagg ccaaggcaag cggatcacct
57301 gaggtcagga gttcgagact ggcctggcca acatggcgaa accccgtctc tacttaaaat
57361 acaaaaatta gccagacgcg gtggtgggca cctgtaatcc cagctattcg ggaggctgag
57421 gcagggagaa ttgctggaac ccgggaggca gaggtcgcag tgagccgaga tcacgccatt
57481 gcgctccagc ctgagcaaca gagtgagact ccaccgcaaa aaaataaata aacagcatga
57541 ggccagtgga atctgtttct ctccctacca gcttttttgt agtttattca aaaagcaaac
57601 agacgtcttt tattatcttg taatattaca tgaaaatctt gttcaaagca gcaagcccaa
57661 atttaccttt gcttaacact aaagttaatt ttaatatctt agaaacaaat ctgtcaaatt
57721 ttaattagtt acatcttaag gtaaaatatt ttataaatat tttataacct tttcaatttc
57781 tattaaaaag cagatcaatg ctccaagaaa gccctgttat tctcatacag tggctcagat
57841 tctgaccttt catcagtgtg gtatttatat taattttcaa tttataggaa aagtaaataa
57901 tccccattac aattttgcca ccttgatcac aaacaaattc tttttacaag aataatcttc
57961 cacacacctt ctataattgg ctgaaaactt tggtttggtc ctgtttttca tttaacttga
58021 aataatcctt aaaaacttct aaactagata acattattat tattattatt attatttttt
58081 tttgagacag agtctcgctc tgtcgcccag gctggagtgc agtggcacga tctcggctca
58141 ctgcaacctc cgcttcccag gttcaagtga ttctcctgcc ttagcctcct gagtagctgg
58201 gactacaggg gcgtgccacc acacccggct aattttttgt atttttagta gagacgtggt
58261 ttcaccgtgt ctactaaaga tggtctccat ctcctgacct cgtgatccac ccaccttggc
58321 ctcccaaagt tcttggatga caggcgtgag ctagcacgcc cggctaatta cgtttaacaa
58381 aacccacatt cctgtgcctc ttataacgtt tttaccaaaa acacatccta ccttttgtca
58441 caggtataac tgactgggac caatattgtg gacagtaaaa taatttaccc aagacagtca
58501 tgggtaaaga aagacagatt tattagagaa agtacaaaga cacattgcaa aagtgcaatg
58561 gtcagcacag caaagaaggg acgtctgcaa agtgtcaggg gctgaaggga agtttcatag
58621 ggttgtactg gaggctacct gtggaatgag gtgcagctgg ggctacatgc ggagtgaggt
58681 atttgggaac aggatgtcat gctagttggt tgtctgtgat cagctgtctc tcagaacaat
58741 tgttctcccc cacctggggc cccttcctcg ttgttgctta cttatcttat taggactcca
58801 cacaaattac tccttatcag attttagcca ggacaaacag ctgatatttc tggcttttta
58861 acttttatac aaaagataac ctcctgagtg aaaccaataa cgcttaacta aggtcattac
58921 tgaaccatgg atgcatggat tccccctgtt ctcaggctac acactagaca gaaagtgagc
58981 taagctattt tcactgtatt cttatctttg caggtgtaaa ctcaaccttt tccccacggc
59041 acttccttgg gttattctga aagcctctgc agtactctga ttatcccgat gtatatacta
59101 catgaaacac tgtctggttt attagttcat ttatctcact aacagcaatc atactaatac
59161 gtttttatga cctgagaagc ctttgcttca aaagaagaag ttttagtagt tgaagtatca
59221 actacaaatc tcaaatgact ctacggttgc ccaccaccat accacacatt tgaagaacca
59281 gcttacgtaa aatccttgac gagaaaggaa ggaatcaaac ctcctaaaac tggttccaaa
59341 cgagcttcat aatcactctg actttctcaa ttaaaatgta ttagtaaaaa taattacata
59401 actttgtcaa agttaacttg taggttaaaa ttatttatct ctttatggca tatccattta
59461 aactaggctt ccaagatgct atgtcaccta tcatagaagg aagaactcct tcattttcat
59521 gaccacaccc atgtggtcat tttcttttct ctgttttttt tttttttttt ttttttttga
59581 gacagagttt cactcttgac tcttgttgcc caggttggag agcaatggca cgatcttggc
59641 tcaacacaac ctccgcctac cggcttcaag cgattctcct acttcagcct cccacgcagc
59701 tgggattaca ggcatgtgcc accacgcccg gctgattttg tatttttatt agagacagga
59761 tttttYcatg ttgatcaggc tggtcttgaa ctcccgacct taggtgatcc gcccgcctcg
59821 gcctcccaaa gtgctgggat tacaggcgtg agccaccacc gtgcctggcc gtgatcattt
59881 ccttaattcg ttcattagta ctttatatta cttccctgat actaacaaat taacttgcac
59941 aagactatag atgcccaaga agtggagaca atatgaacta tgttgcttgc tagtatctta
60001 attttaattg ttctcccatc attatgtgtt ctaatacata atagatgaaa ttaataatct
60061 ctccctttct gtcaaaacta tagggcatca atgatattga agctacaaat atacagatta
60121 tgaagaccta agttttgact cctacataat tcccacaaca gacttaaaat caagagagct
60181 gtggttactt gaagttgaca gttgagtagt tctccctata gaaatattaa ttcatatgtt
60241 aatttcatca gaagatgtcc tatatttgtg agccatacca tcacatcaat aggcctaaaa
60301 atcgttRcaa tcccagggca tttaaaccaa gcaaccttaa catctatacg accagacctt
60361 tactacagac aatgcccaga aatctgcaga tccaaccatg gctttatacc cattgttctt
60421 gaactagtcc ccctaaagca cttcgaaaat tggtcagcct ctgtatcata atatcactgt
60481 gaagctaatt agcattaacc ttttatgtta aagaccgaga gccaggattt ctccacatta
60541 aaatgtccca actaaacaca tctacattat ttactatggt tttatgtata atcatatcac
60601 tctttatctt atttcaatta aaattctcaa aatttatctc cccaataagc tcaacactaa
60661 aattctttga atcacagaaa cttgaaattc cttgagaaat Raaatgaatg gaaatgtatt
60721 tgcctttcat tgccctaaca gtaatacgaa gacccgtagt tataatctcc tatttccaag
60781 tattttattt ctatcatcta gtcacctgat taacaactgg ctaatctcca ttcaacagcg
60841 actaattcaa ctcatattaa aacaaatgat aataatacat aataccaatg gatgaagctg
60901 atcccttata ctaatttcat gtattctgtt tattggctca actaatttac tRggaggctt
60961 cccactcaca ccaactactc aactctcaat aaatttaggt atagctattc cagtatgagc
61021 aggagcagta attactggtt tttgtcacaa aacaaaagca tcccttgctt atttcctacc
61081 acaaggaatg cctatttaac ttctctcttt tctagtcatc gtcaaaacca ttagcctttt 61141 cattcaacca atagccttac ccatatgatt gacagccaat attacaactg taaatgtaaa
61201 ttatacattt aactggaggt gccatcttag tatcaacatc tattagccta cccacagcct
61261 cagtcccatt tattaccttg attttactag ccgttcttga atttgccatg gttttaatcc
61321 aagcatatgt ttttacaatt tttttttgag acagagtcta gctctatcac tcatgctgaa
61381 atgtagtgac atgatcttgg Yttactacag cctccaactc ctgggctcaa gcagtcctcc
61441 agcctagcct ctggagtagc tgggactaca gtttcatgtc accatgtctg actatttttt
61501 tattttttat tttttggtta gatggggttt tatcaatgtg cccaggctgg tctcaaactc
61561 ttaggttcaa gcaatctacc tgccttggcc tcccaaagtg ggattatagg tgtgagacac
61621 catactcagt ggtttttaca cttctagtga gcctctactc acatgatagt actttacgac
61681 ctacaaaacc caagcatata atagagtaag cttcagccct tggccattca caggggcgct
61741 cataactact gtaacacttg ttgaaaggca ctcattacaa catctgtctt agccatatga
61801 ttccactcga actcaattac tctattaacc ctaggcctag taactaatac attaacaatg
61861 tatcaatcat aatgagacaa tatcagagaa ggcacattcc atggccacca cttgtcaatt
61921 gtccgaaagg gccttagata tggaataatt ttatttatcc catcagaagt agttttctct
61981 gctggattct tctgagcatt caagcctggt cccaatccca gaactcggag gctgctgacc
62041 tccaacaggt atttacctcc ttaacccctt cgaagtgccc ctactcaaca tatccattct
62101 ctcagctttg ggagtatcaa ttacctgagc ccatcatagt ttgaaagaag aaaaccaaaa
62161 acacatactc caaaccttat ccattacgat tgccctggat atttacttta cactcttcca
62221 agcctcagaa tgcttccagg cacctttcac cacctctcat ggcatatatg gctcaacatt
62281 ctctatcgct acagacttcc atggacttca cgtcatcaat ggctcaacct tcctaaccat
62341 ctgccttgtg catcaacgaa aatttcactc atcagactYt tgccaaattc cattgcacat
62401 ctgctctaca atcaaagaca ccttggatct aattctcctt ctaatattac tactcatatc
62461 agtactgttc tcaactgacc tattaggaga ctcagacaat tacactccag caaatctcct
62521 caacacacca cccgacatta aaccagaatg gtgcctttca tttgcctatg caattctaca
62581 ttaaaccaga agggtgtctt ctatttgcct atgcaattcc acattaaacc acagtagtgt
62641 atttcatttg ccaatgcaat tccacatgaa accagaatgg caactttcat ttgcctatgt
62701 aattccacat taaaccagaa tggtactttt catttgccta tgcaattcta cactccattc
62761 ctaatgaact aggaggcatg ctggcccttg tcttctccat tcttatccta gctgttgttc
62821 caacacttca catatctaaa caacaaggca taatattctg accattaagY caatgtctRt
62881 tctgaattct agtagcagac cttcttacac ttacatgaat cgggggccaa cctgttgaac
62941 acctctttat tattatgagc caagcagcat ccattgtgta cttttccctt atccttcttt
63001 ttataccaat tactagccta atcgaaaacg agctactcaa atgaagaagt ccttgtagta
63061 tcattaagtg actctggtct gtaaaccaaa aatggaggac ccggctcctt gggaccattt
63121 ccaggaagaa gcttcttgct ccacaaccag cacccaaagc tgaaattcta cttaaactat
63181 tccctgattt ttgtacttga agtgcaatac atttatttta actgctatgt cagattggaa
63241 aatccacata aattactgtt gcaactatgt acatcatgca ttcctgcttg accccatgaa
63301 ttaacatgct agtactagat gtgcctgatc gtatattgta tatttatgta tcgtacctta
63361 aatcttcacc tccatgaata tttagcagga gtaataatgt cacagcaacc tgtcatacat
63421 tcatcaaaca ttctgcagaa agcgattaac atacatatat atcatccagt ataataatcc
63481 cttaatattg cataggacWt tcagttattt atgaatcata gcacattcaa gtcaaatcat
63541 ttctcagcaa cacgcttatc acctcctaaa aacattctta actaacaagc tttgagaaat
63601 cagcagcctg cttggaaagt tctatccttc ttactcccgg cccatgacac ttgggggtaa
63661 ttagactgca actatacctg gcatctggtt cttccttcag ggccatggag actaagatcg
63721 tccacttgtt cctcttaaat aagacacctc aatgatttag tgacaatcac ctcatggtca
63781 cttgcagaag tactgacatg tatttggtag tttttaaatt gggagatgct atgactcagc
63841 atggtgggag cctgaaccca gccaactcca ttgtagctgg agtttaatgg aatattacga
63901 gtcaacactt acaaccacaa ggtgctaatt tattcatgct tgacagatat catgaaaaga
63961 aaatgcacgt tcaagctcac cctttctcca aacatgtatc tgatttactc ctcaaactcc
64021 cctgccccct tttccctgga ctaacctaat tatgccaaaa aaaattgttt gttcttgcca
64081 agcccaaaaa caagatatgt ataacatcaa tgacagccag ggctcacact ccaaatcaaa
64141 ttgtaatctc aactacaatt acattttagc caaactttca attaaaccta tttcaaaaac
64201 acatgattgt aaaataaaaa ccaggctatc taggctaaaa atcccacttt ttatttctaa
64261 agttactaaa tattgcccta ataNctagca tagtacttca acccttcatt ttgtaacaga
64321 gagaaaattg tctagatccg aattaatgta gcttatgata ttaaaacaag gcactgaaaa
64381 tgcctaggtt agttcatgta actccatRaa cacaaaggca tagttctggt ctttttattg
64441 ggttttaata agattacaca tgtaagcatc tggattccag tgaaaacgcc ctccagatca
64501 tctaatttca aaaggagcag gtactaagtg cacagcccta catcataaca ccttgctcaa
64561 ccacgacccc acgggaaaca gcagtgataa aaaaaaaaaa aagcaataaa tgaaagtttg
64621 actaagctat actaaactat tagggttggt aaatttcatg ccagctaccg gagtcataca
64681 attaacccaa actcacaaaa acaagcattc agcgtgttta aggcaattct cataataaag
64741 ctaaacttta aaccgagccR tgaaaagctc aagctaaaat aaaaagaaac tacaacaatg
64801 attttagtat cctgagaaca tgatagctaa ggcccaaact gggactaaat ctctcactgt
64861 gcttagccat aaacttaaat aatttaataa acagaattat ttaccagagc actataagca
64921 atagcttaag cctcaaagga catggcgatg ctttacagct ctcgagaggg gcctgttcta
64981 tattcaataa gctccgatat acctcagcat ctcttggtaa ctcagcctgt atactgctta 65041 aacaatctca caggaagtca ccccatctat taattattct tttatcagtc cccttgataa
65101 gtgggtcatc cactttatca tctcttattc ttgcacaata atctgcatga ttgattttac
65161 catcatgacc cctgtccata atgtaattca tctcaacact agcagaaact aaccgagccc
65221 catttgaccR gcagaatgtg atttagagct agtctcaggc ttcagtatag ttatttattt
65281 aatttttttt ttgagacaaa gtctcactct gtcacccagg ctggagtgca atggtgcgat
65341 ctcggcttac tgcaacctct gcctctgggc tcaagcgatt ctcgagcctc agcctcctga
65401 gtagctggga ttacaggtgc acaccaccat cctagctgat ttttgtattt ttaatggaga
65461 tggggtttct ccatgttgac tgggctggct ctggaactcc tgacctcatg tgatccacct
65521 gcatcgacct cccaaactgc tgagattaca ggagtgagcc attgcgcccg gcccggcttc
65581 aatgttgaat atgctgcagg ttcattggtt gtttcttcat agcagaatat actaacatta
65641 ttataataaa tgtcctaact actattattt ttccaggagt actacatgat gtctttatag
65701 caaaaatcta tacaattaat tccattacca aactctccta ctgagaaccc tgtttctgtg
65761 aatcagggca tcagacctat gagtttgata tgatcaactt atgcatcttc ccgtgaaaaa
65821 actttctatt ccttactcta gccctatgca tacagaatgt ttaaatatct gtcctaatat
65881 ctagtattca gccacaaaca tgggaaatat gtctgataag agagttactt tgacagagta
65941 aattacagag gtttaaatct tcctatttct agaattacag gaattgaaac tagtcctaag
66001 aagtcaaaat tctccatgct atctgataca ccatgtccta tagtaatagc agctaataag
66061 taagggcagc ttaccctatg gtaatggcag ctaaataagt tatcaggccc atacccaaaa
66121 tatgctRgtt tatacccttc ctgtactaat cagttctcta atcttcctca ctatcctatt
66181 cactattttt atagaaactg taat atagt aatcgcctta cactgtctct taatctgaaa
66241 ggattagaaa taaatatgct agtcataatc cccataaaag gccaaaccca ggccgggaat
66301 ggtggctcac acctataatc tcaacacttt gggtggctga ggtgggtgga ctgcttaagg
66361 ccaggaggtc gagaccagcc tcggcaacat tcatagggag tgaggccatg cttggtagtg
66421 agtgactcat tcaaagtttt catggtttca gggagattct tagtctagga cccccaagag
66481 ccatcctggg acagtgctca tatgtgggtc tttagcaggg cactcttcca ctgaggtctg
66541 ccccagtggg ttacatgagc tgtggaacct ccagtctatg gattgttctg atgcccagtg
66601 ctggaaatca tggcccatga aagggggccc tgaYctctat ctgtcctttt agccatgcca
66661 ttcgtgacac taagagcggt gagacRcttc atgStctcca gttgggtggc acgttttaca
66721 ctgaaggcct gtagtagcct cattgttgta tccacacagg ttaagtcata ccgtttccct
66781 ccgctctggg gcgggggggc caataaaatc gactcgccag tcccgcacag gttgtatggc
66841 tcgatgtatg tgacccggtg tggagggaac ctttctagtc gcagccatga acaggtcccg
66901 gggttctgaa cagctgctag attatctgca cagtgggcag ggaagcctac agtctttgct
66961 ttggcccacc tcatggctgc cccctggtgg tcgctcttat aaggtagcca catggcagcc
67021 tcccacaatg ggctccagca aaccatggga acatgcttaa gggcgcctgc ctcctgattt
67081 ccaggagaca gcttaggact atgtgcatca acRtggtaca ccataagatg cacatcattc
67141 ttttgtcacc tgacgtggat attctgccac atggacaggc cctcaaaggg gcctgcccca
67201 aacctcccaa ctgtaagcag cccattgact gctttgtcgt tacccccatt ctatccRtat
67261 ggtgtcagta tccatttgca ccgtcagcac tgaccgtaag tgttaggtgc tcttgctagt
67321 tccatgtgtt tgcctggcag atatcgtaag ggtcgcctca tatatggtag ttggcatggt
67381 aggtggatct attgccatgt ccRctctttc aagcacgtcc tgtagtactt gacttaaagg
67441 actagtggac agggcatccc tttgttgcag agaggcatgg catttctgta ggatgtgtgg
67501 ttgtgccacc ccgggaggcg ggσttggcta ggagaccttc cattcaccct tgtataaggt
67561 aggcagtctt tactgggaca gtctgctttc tggcgatggc ctctgctcRt tgcaatgtcc
67621 tatacatggc caatagctgc tgctccagca ctgtaaagtg agattctgct cccttccaca
67681 gttgagactg aaaccctaca ggtaccattc ctgtgggttg catttgcgac aaactccaac
67741 tcaggtcagt ggcgtctcta gtgacttcca gtacaagagg gtgctgtggt catgaggctc
67801 ctgttgcttg agcttgtttc acccatattt tgttttgtca gaagcctctt gctccatatc
67861 tgtccagtcc catttgtttc acctttcttt attagagtgt ataatgggca aagggattgt
67921 gccaaatgag gaatgaatat cctccagtag cccagtaaac ctaggaaaac ctgcagttgc
67981 tttactgtct gaggaacagc atggatgcgg gcttgatggt cccctggggc ccatcggagt
68041 ctcttcccag gaaattggag gacctgaagg aaaaccctta gaggcagcag gcagtggagc
68101 tgaggcctga agaggagctg gtttcccact gctgacaccc ctgaggcttt ccggatccct
68161 ggtcttccct aaacctggct ttaaaattgc ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt
68221 gtgtgtgtct gtccatacat gtgtgtgtgc acacccatag atttctttat ttatttaatt
68281 ctgtgagctt tctctctgga ttcttccaat acatgtctct actgcagagt tagccagagg
68341 attttaaaaa gctttcgctt cacttttgtt cttgcatttg cttttgactt tgttttgctt
68401 tgcgctctcc ttgcttcNaa aaaaaaatgt taactgatac aaacattgtc ccaaagagtt
68461 ggttgcagat cacaggccct cagatgattg gcatatttgg aataagtttt caggctgaga
68521 ggagggcaga gcaacagtga gccaccccca accccagcat tccggggagc acctgctgtc
68581 atcttgtgga aaggggcaag gaacgctggS acctgaagca ggataggtca cttcagacaa
68641 atgcctggct ttgacatttt tcctgaaggc gtctgataaa ttgtggctgt tgatattttt
68701 ggctgacttt cctatgaaaa gcaaattctg taggtttctg gttacatgat aaatttcgtc
68761 ctcgccagat cttctaagcg cacatgaggg ccctgatagg gagagagtgg tgtgttagct
68821 cctcccctgc tgtaacaaag caccacagac acagtggctc aaaccaacac gaagttcttc
68881 tggagctcag aagtcctaaa atcaaggtgt gggcagagct gcgttccttc tggaggctct 68941 ggaagaagaa gccattccat tgcctcttcc agctcttgga ggaaactgct ggccttggct
69001 cctgtctcct tccttcctct tcaaagtcag ccttgtagca tcctccgatc tctcccagtc
69061 tctctcccct tctatcatct catctccttt tctccctctc accctactgt ctctgcctta
69121 gaaggaccct tgtggttaca ttggacccac ttaaagaatc ccaaataatc tcccatctcc
69181 agatccttat ctggacgata actgcaaggt cccttttatg atggaaggtg atataatcgc
69241 aagtcccagg gttaggacat gcacatctgt agggggctgt tattcagcct aaaacaagtt
69301 gcatcaagaa aattacgatg gggatatcaa ggagtttgaa gaatcccaac tcgtagccat
69361 gtctaagggc ttttctgagg tacaggcccc gctagaggaa gctgctccaa ctctgttcct
69421 gtctgctcct gccccactct ctgtttctag acagcctgcg ttcaagtcat tgtggcccaa
69481 gactgaactg cagaatggaa aggagtgagg cgctgcagca gaaggagctc gctgtcaaag
69541 ctccaaagag ccggagacca tttgcagggt ggggtctgag ggaggttggc aaggaaaggg
69601 gagcatcatg tggattcctt tccatagtYg tcatgagcta acacacttcg ccccaacagc
69661 tggcttagat tctaattgtg cccaggactg gccatgcaac ccttgagtaa atgctggcca
69721 cctctctatg acaccaaaag gccagaaatt acctggcatg ataaagaaga aggagtcaag
69781 tgtataggag accggagggt tagactggat ttctcaggcg ctttctgccc tgactgtgtg
69841 ctgccagggc ccaggagatt cccctttcct ttgatgagaa gaatcagtgg atattctcta
69901 gagctctcta gaatggggga ggggctagga ccctggtctc tttagggtgg gagaaattcc
69961 aagaggcaaa ccctagggtg aggcaggtgg tggccagaag aaaagagtgt ggacaccagg
70021 tcaRgaagca gggagggcgc atgatctggg c cagggacg ttccacatgc agaatccagc
70081 aacagagctg gtggacagtc tactgacttc gcaaaacccc cagtctggtg agcaggcacc
70141 tgtcacaggt catcatgctg gatggcccct gcttgtcact caattctcag gcctgactca
70201 tagcacagac ccagagccct tgaaggaaag ggaggccagg agtctgcaaa aggccccgtc
70261 atttcccata agtgcagcct gtgagcgttc ctcctacctg ttctccctgg acctggagcg
70321 tcccctcaga tcacagggga cggcttaaag gaaacccatc cccaggactg ttggatccca
70381 tccagactga caccaattcc tgggacccat aatgacccag agtgccactg tggtgttcca
70441 gtcagagggg gggttacagg gaacaagtaa tgaatgaata tctgatttca gtttactttt
70501 caataagtct atcacctggt tattattttt taaattcctg ggtggataac tggaatgcat
70561 attcttggaa gcttcagatt gttcacgtag acccacggat gatgactatt tcagtgacag
70621 acgccggtgg aagccgttgg ttttacatac ctgcctaaat attttaatca gagtcaacag
70681 caaattcatg gaggagttag agagattgct gccatcatca aggtttaaag ggagcagaag
70741 cagtgattcc tgtgactcac ctgttcacct cttcaatgca gccagtcgtc agcagggaaa
70801 caactgtttg tcttccaaca gcagaacaaa gσaggaagct catcagtRga agctgccatt
70861 cctaaggtgt tcttgttaat gaagcaaata aacacagcct gcagctctca gtctctatca
70921 atcaggcttc ttggtcaagc agaggtacca tctctggttt ttaagggcag aaaacaacat
70981 gaaattcact ggaatcatat cagaagagcc ccacctgcag aggaggctgg agtttggctt
71041 ggaagataaa aagaagccaa gacagtgaca cggtatcaag gctgcgagca caagagccct
71101 gctttgtgag gagtgacacg gccacagcgc tgccccgcca cctgcggaca tcatctctgc
71161 aggtgcagga ctcggtcgcc ctcttctcta ttctcctcct gggcagtcct gctgctctca
71221 ctgagaatgg gttctaagca ccctgggctt tgcctcactt gctccagttt cagaatccca
71281 tgtggaagca gccaattagc cagcctagct cttggacagg agccctggat gccagagtgg
71341 gggtagggag tgggagaatc tacttgcctt agaatcacag agggaaatgg gcccagcctc
71401 tctctatgac tacacatgct ggcaaacScc caaagtagga agaggaaaat agatgcggaa
71461 gagttccctg ctgtgaaaca agtttgttcc atctcttggt tctaaatatt gacatctttg
71521 attgtacaag gcagacccct aactctaatt tgYgaaaact aaatagagat acataactca
71581 cagaccatga gggctgaatg caggtgctta cactgagtta tgagtactca acRtctctca
71641 aattctgctg tgctttcctc ctggcccacc tgctcccacc aggcctggcc tgctgtggaa
71701 cacctctcag ggatggttcc tgaagagcag tggagcacac ctcacagtcc aggctgcctg
71761 ga ggagMRg tgtcctcggg aaggatctgc cttgtttgct gggtaacagt tgaggatttg
71821 gctgtaagtt cagcatttta gaaggaatac gtctggaggc ttggtgacaa agatatttag
71881 ggaagaggta tacagataaa gattttagaa tgagcccaga gcaaaaaaaa gaaagagaaa
71941 aaaactaccc ctgtcccatg tgaatactga ctagaaagtc tccactctca agagactcat
72001 atacagggaa gaagtcactt ttgtggctgc aagtctcctc tgttcccagg gcggcccggt
72061 attttcagaa tgggctccat aaccaggtgc gtgatgtgga gctcggtgta accacgcaac
72121 acggatccct cctcaaggct gagcacttgg catcgtccag tgaatctcaa ccccggaagt
72181 cacagcctta gagagcatgg aaatggcccg aaggggactc agttccatgt cagaggctgg
72241 gaactgcctt taggatgtgc tatgttttga attcataccc aaaatttacc tcatttcctg
72301 tgatagccag aatttatgga gctggacagt aagaggttaa gatgagggtg atagctctat
72361 ggttacaaac aataagtcac tttcaaaaat cttgtttaca atacccctaa ctcagagact
72421 tttaagtcta gaagtttcag tatctaaggt gggaatgcct cctgcaaggc tgacaaaagt
72481 ggtttcagag gtgcccatag ctggcttctc atgctccctg atgtagggat agcaatgacg
72541 tcactgggtt agatataatc atggatcatg atcatccagg gaagctcatg ttgttactac
72601 acagcaggac atgaggaatc gagggatccc ctaggattgc tccttgtaat actctaacaa
72661 gttgtaaagg tgaataggaa atttcaccac cttactgagg ccagaccatc aaggagctta
72721 gaccccacaa gaatgacttc gcccataagt aagaggaaca ttgagtggaa cagtcaaaga
72781 cttgtgacgg tggcagcaat ggtcagtggt ggttgtagcc ttgaccgcac ctctctgttt 72841 cctacaaata tacacacaga aaatgctgag ataggagctg ccaatggacc aagagaaaaa
72901 ttgacagtgt gccgaggcct tcctcctgtg acataacttc agcatgcaga agagggcgat
72961 ggtgtgtgtg gctctctttg gagaagaagc aagtgcattt gtctttgtcg ttcggatggc
73021 tggattcata acaggtaaRg agagtttttt gtttgttttt cgagacggag tttcgctctt
73081 tcaccaggct ggactgcagt ggcgtgatct cagctcgctg caagctctgc ctcccggatt
73141 caagcaattc tcctgcttca gcctcctgag tagctgggat tacaggcatg tatcaccatg
73201 cctggctaat ttttgtattt ttagtagaga cggggtttca tcatgttggc catgctggtc
73261 ttgaactcct gaactcaaat gatccgcccg ctgcaaccac gcgaagtgct gggattacag
73321 gcgtRagcca ctgtgcccag tcgaaaaggg ttctttttgt ttgtatgaga agaagggtac
73381 gtgtgtgtgg tagcaagcag ttgactatat aMaataagca caaattcagg tgactgtttg
73441 gccagaggct tcccattagg gtttgtgtct ctgttactca tcgctgttcc tgataccata
73501 gcctgactga ttggttcaag aacagtcact gacccaagct atcctcYcat ttgagaatgt
73561 gaaactttaa tcagagacac taggaatcaa agtgtgtgga gctaagccag gtgcaggcag
73621 agccctgaaa gggcaaacca tatattcctg atgttggtaa tggtctgctc ctgtccttcc
73681 aaattctgta gattttgttc ttccttccat cctctgacct gctctagttt tcatccaatg
73741 aatcttctat tttgtttaag acagatagWt tctgtttctg ttgcttgcaa ttgaaaaatt
73801 tttaaRcaat actagcagta cagtggaatt gcatcaaatg caggtagcct gatggcattt
73861 caactctaag tgtcagggca aatgctggct ggatcactga agaagtaaat tactcagtgc
73921 cagaaacatt caaagcttaa gtgaaatgta tgaaaagaat gggaattatc caggaattga
73981 tgaacaattg acagacaaat gaaacacaat gttctggcgt taggcaagtc ggtggccgtt
74041 gctctgttga cttcttcagg aagaaataga tgaatcaact gaaggtcagg gaagccttgg
74101 ctgatggaga gttacaggga ctgaggcaag tgttctgcag gatgctacat aaaaaaggac
74161 taagtaggcc ctgggtgcac tttacgagtg acttaggaga ggttctgggg tgattttgtg
74221 cattctgtat ctcttgcccc tgctctgggc tccagctgag gcgcccagca gttctatatt
74281 ctatgcatgg aaatacagat aattaatgtc cactggggca aggccatggg ggacaggagc
74341 agtggttaca ggcctccctc tctcctccct gtagaggaac attctgaaga cgctccttga
74401 agactcctca ggaggtctcc agtcgcccac atgggtgacc ctatcaagaa tttctcccgg
74461 catcagYctt cYRtccttct cYgtgtcact cctMccagta ccccagtcct gctcctagaa
74521 tcacttccca aacaaatcct ctgcctggga gccttgccta gggctctccc ttcaggggaa
74581 ctcaggccac aRcagcctac attagacagc atgaaggctc tgggcttttg tgctaagagt
74641 aataggaagc cattgaagac atggaagccK gKgtttgatg aaatctgtgt ttttatgggt
74701 caacttggcc caaKgtggag gaWgagctgg cctagσggca agggctgtRt atcagcgaag
74761 accattttgg aagcttttgc aggagtctgg gcgaagtgag aaggctgact ggatgagggt
74821 gtttgcagac tggatgaggg tatttgctgt ctggctgtct Stctctgtcc ctctatgtct
74881 catggatttt cYYtcaacct acatacaggc ccttctgatc ttagcctcat gtgacccatg
74941 tcaatcctgg gccctggctg ctagatcagg accacgcctg tactagagcc aagccagaag
75001 tctacaagtt ttccctgagt gcttcagggg ccactgggca ctgggttcgc agagaaatga
75061 gcagtctgga gagtaagcag aaggggccat ggaggcctag ctccctgaga gcctggaaga
75121 agaatcatga ggaagagaag tcaggcaccc agagcctagg ggagcccata tatcaRcaca
75181 caaaggctca gtcatcagtc agtgttgctt gaacacaagt ctctagaaca caagagaaga
75241 gggccaggtg gatgtgagat atcatcttgt ccagcccccc tttcccagct gatgaggaaa
75301 ctgaggctca gagagatggg gtctcttgac tgcaggctgg ttcatctcct caatgcacca
75361 caacattcct tgacttgttc ctggcatctg gttttgcttt tatttttctt cacacatcaa
75421 cgtttccaat atagcatttg gagtttcatt gaaatgtcat cggtccctca gtgtacgctg
75481 gccccaagca gggccgaccc catgtcaagt cctcttgctg tctgctgaca tcaccacaat
75541 cacctttacc actgttagga caaaaacttg agacaggaac ttgccctcaa agcgggaaag
75601 gagccatgag accaaggaat gacttaaaca agtccagctt ggcgagtagc taagtttatt
75661 aggacttaca cacagggcac tcagcaagac agctcgagag atccRgcctc ccccaatgtc
75721 taaactgctt ttcagttaat tttctggctc tttgtctact atatatgagc aacgagactt
75781 ttacttggtt ggttctcaga tactctccag gatgtttgga ttctcagaga cacctggtcc
75841 tcagctgggc accatggaaa tggctcatta cccggccttc agggttcaag caggggacat
75901 gcacccttaa ataacctaaa ggggacctgt cacactacaa ccaccaccac catcatcaag
75961 aagccactgg ctgactcaga tacaccccYg ggaggacaag ggagagtgga tgctggtaag
76021 acagggYgag agaccatcac cagggaagga ttccattctt ggaaggacat ccaaccgggg
76081 ggcgggtctt tagtggagcc gctgtttctt ctcctgtatc caacagttct aactgtggct
76141 ttctccattt tcagctcttt cttttcctgg tcttctcatt gcttgttcct acgtgcctcc
76201 ctctcttcct cccccaatat actctttagt ctagagtaaa ctgcttcttt ccattcccca
76261 cactctccag tcccctctcc tcccttattc caggccccag catttctgcc ttctccttgg
76321 cgcacttgcc atcttgagta acccctcccc tgctgtgctc agctacagat gccaaagttc
76381 ctaacactga gttccataaa ctttacctcg ccctctttat tcccctaaaa aatgtctgcg
76441 ttttgtcccg gcctgtgtct ggctcacctt ccctggtggc tgcactgctc tggggtcatt
76501 gggtatcggg gaacctgccc cgatggtcac gtaggttctt ttctattttc cctaagtgtt
76561 ggccggtttg agaaataaag gcacagagta caaaagagag aaattttaaa gctaggtgtc
76621 caggggagac atcacacatc ggtaggttcc gtgatgcctc acaagccgca aaaccagcaa
76681 gtttttatta gggactttca aaaggggagg gagtgtatga atagggtgtg ggtgtgggtc 76741 acaaagatca cctacttcac aaggtaatag aatatcacaa ggcaagtgga ggcagggcga
76801 gatcacagga acacaggacc ggggagaaat taaaattgct aatgaggttt cgggcaccat
76861 tgtcattgat aacatcttat caggagacag ggttttgaga gcaaccggtc tgaccaaaat
76921 ttattaggcg ggaatttcct cttcctaata agcctgggag cgctatggga gactggggtt
76981 tatttcatcc ctacagtctc gaccatagaa gatggccaca cσcaaggagg ccatttatag
77041 acccaccctc aggggtgcat tctctttctc agggatgttc cttgctgaga aaaagaattc
77101 agcgatattt ctcccatttg cttttgaaag aagagaaata tgactctgtt ccaccaggct
77161 cactgttggt cagagtttaa ggttatctct cttattccct gaacaattgc tgttatcctg
77221 ttcttttttc aaggtgccca gatttcatat tgttcaaaca cacatgctct acaatttgtg
77281 cagttaacgc aattatcaca tggtcctgag gtgacataca tcctcctcag ctgacaggat
77341 taggagatta aagtaaagac aggcataaga aatcacaagg gtattgattg gggaagtgat
77401 cagtgtccat gaaatcttca caatttgtgt ttagagattg cggtaaagac aggcatagga
77461 aattataaaa gtattaattt ggggaactaa taaatgtcca tgaaatcttc acaatccacg
77521 ttcttctgcc atggcttcag ccagtccctc cgtttggggt ccctgacttc ccgcaacaat
77581 tgggcctagc ctgcttttag actctgatgg atatgggtga gctcattgag attctcctcc
77641 agctcctgag cccactgcct cagcgactca gcagactcgg attttgcccc cttgtgcaag
77701 tccagtgagt cttgcacaag gttgactaca tccagcacaa caaggacacc tgaagtggcc
77761 ttgcccaggt tccgggctac ttttctcact atccgggtgg gggccccacg tgttctcagt
77821 gtctcaaaaa catttatagg tacatatcgc caagcaatca aagggcgtcc aacagtggct
77881 ttagatctcc tgagtgtatg gacatcattc gcaatcattt ttgtggcttc gtcaaaatca
77941 agtgcaaaRg aaagcacatt gggtgtgatg tcaYgcagaa tgtcccttaa tgcctccaat
78001 tggtcagtgc tggttgcagt cagcctgctg gctgtgagtt ctgctgacct tgtgtatgtg
78061 ttctccacga tgctggaggc gatcccagcc gtggcagatg ctattcccag ccctacccca
78121 gctgcagtaa tgctcaggct cagccctgct gtaaatggtg ccaacaYaac gccaatgaca
78181 gacaggatgc cagtggagcc agacaccaca ttggcgatga cgcagcctct gtggaccttt
78241 tcaatctcat ttgcaatgac acgaagcctt tctatggact cctgaatctt ccatctgatt
78301 tgaggaaacN ttcaaaaacc actccctaaa ctgctgttct ttttgctgca tgtctttgtc
78361 ctcaatagcc acatatggtg taagattctt cagagcttca tagagagcat ctgcYtcttc
78421 cctgtaccaa taaaggacag atgattaaga aaggcagctt acttacctgt aaaatgagct
78481 caataagatc tattctgcat aaatcacaga gctgtttcta taagtcaaat ggaagtaaag
78541 ttctaaaaga taaataattc ttttcaaggc cgggYgcggt ggctcatgcY tgtaatccca
78601 gcactttggg aggccgagat gggtggatca caaggtcagg agatcgagac catcctagct
78661 aacacggtga aaccccgtct ctactaaaaa tacaaaaaat tagccaggYg tggtggtgag
78721 tgcctgtagt cccagctact tgggaggctg aggcaggaga atggcatgaa tccaggaggt
78781 ggagcttgca gtgagccgag atcgcgccac tgcactccag cctgggcgac agagcgagac
78841 tccatctcaa aaaaaaataa taataataat tctaYtcaag gttaaatatg ttttgtacaa
78901 catagatatg ccacagtact tattcagtat gggaaaaaat aagttaaagt catcttccga
78961 tgctctttag tggctatgtg tttgataaag atggctcctc atgcaaggga ggtcaatgcc
79021 atcactacca gggtgtgtgg agaggggaaa ctttgtagaa aaacaaagag aagtgggttc
79081 agagcaaaaa gaccttcatt cagaggatca tagaacagtg atgaattaac tttattagaa
79141 gagagcatat ccctttgtcc tcggcccctg gaaagggatc tctggggccc tggaatgtcc
79201 tgcctggtag gaacgtcttt gtttccctgg tggtttggct acaggccagt atagcaatgt
79261 gatgggtgat gggcgtttag ggctattagg tgtctcatct gccttccaga ggaactgagg
79321 actaaagggg ttagaccttg gggaagggct ggagactcca tgtctgccat gacggcagct
79381 tgtgatccag ccccaggaag agctctgcat tgtcatgagt taagaaagac ttactccttg
79441 gccaaacttc agttgggcgg ttctgagcct cttctcctct agacattgac cttggccttc
79501 catgcccatc ccgtgcttgc tgggcctgca ccgccccagc tcagcaagaa tcccccaaag
79561 tcaatttaga gaggatcccc ccagcttgct gtctgagcac acttgctctc tgatcacggt
79621 cttcacccat tcatttgata agcgactgtc tgacctgcct ttagggagca tcctgttagg
79681 ccagtttagc aggaaccccc cactctggtg tctcctgtca gtcctgttcc atctgccgcc
79741 ccttaccctg gtgttggctg tgactccccc tctgacttta ctgtattggg agctgggctc
79801 agtctccctc ccctgtaaca acaatcctga ataaaggctt ccttcctgat ttaatgtgat
79861 tcaYaggaat ttttccttaa ctgggtgagc ttccctggtt ggcaacaccc catgtgtttt
79921 gttccacatt gacacaggag aacacagcct cctgaggaca atgaagcttc acaactgaaa
79981 ccctctcaga ctctgccctg tatgtctctt ccttaatctg tgttctttcc ctgtgataaa
80041 ccacaatcgt gcaataacag ttatcagtga gttacgtgag tccttgtagt gaattatcca
80101 acctgagggg ggcttaagaa agcccctcaa gtttgcaact ggtgtcagaa gtaagggtgc
80161 actcgaacgt tgcagttcac ctaaatctga gtccttaaga attcaaacac aacctcagac
80221 tagaaggtgt caatttgcct ggcatgttct ctcttccaat gcctcatgcc ctttgacgtt
80281 ctgactaaag gccactgggt ccagccactg ccacctatga ctgaaaagtg gaagacctgg
80341 ctattagtcc tggctgcaca caaactctca agccacctta ctgcctcctg acctggcacc
80401 tccaaacttc agggtctcac tctcacatgt caccagccaa actaatgcct tagcaggtga
80461 cagcttcatg tgtatacagg tcaaggccct gtacaatttc atggaagctc ttgaggactc
80521 atgaggactt tgaaaatcat ctctataaat cactaatgct gaaaagacct gcatttggac
80581 aagatggtag agaaagtgtt tttctctttg gttggggact tgtgagtctt ccgagaaccc 80641 ttcaaattac accagttgaa gccactcgtc cccactctgg aagttggcct gaagaaacat
80701 tgcctctact ctatgtagaa cagaagaagg tttcaaatgg cagcccagaa ctccccattt
80761 cccaggcatg gtgtcgggga aacagtcacc catggcccac tatgcccatc agtgatggga
80821 tcaaatcagg gagggaagaa atatccctct cctactcacg ggtcttctgc aagtccatga
80881 ccatgttaca tttcatgctc tcagtgtctc ccttctctca ccctcctccc agccttgatg
80941 ctccagcctt cctgctgctc ctccaatcta ggtccacccc tgccccatcc tgacccctgg
81001 ctctgcccct ggcaatgtct ctctgggtct ttgggcggca tcatgctatt tggttcccca
81061 cctttgacct ggagttcatt ctaaggcctt caccacactc ccatctgatt gaattactaa
81121 tagcattgga cagacggcag gtcccagtct ccaagacata aaccaacagc cccagagctg
81181 tgcagggaca gagccaggat ccaccccagc tctgtccaac tccattccag cctctctgtg
81241 tcctgg tca gcagaaggat tctgctgtgt ttgtgcagtt cctcagaagt tcaggaaaag
81301 ggccccagac agcatYtccR ggaacacaca ttgatcaggt caagattttt ctgacttttc
81361 ccaaag aag tcctgctggg cttccatctc taagaaaaag acttttggYc ctggtctctt
81421 gccagcaagt tttgtaaaag gtaacgctaa ctgagcacct actgtgtgtc agtcattatg
81481 ctaaatactt tacatgcatt atcttatttt tctcacaata aagctcaatg gatgaagaaa
81541 ggaaagcaga aagtagtcaa gtagcttgca aagctcccat caccagtaga tggcagaact
81601 gaccctgccc ttgtgggctt cttctcccct cagcctgagg tcactcactg ccagcgaagc
81661 acttggagga aatattcttc ctgcactgct gagagggaca tcctcaagcc cagcagaggg
81721 ggctgcctgg aggaggYgtg cctgccagag aaaactagcc cggggagatc tgggtggcat
81781 caccggggtg ccccaaggag gtaaccccat ggaggttacc tgggcaattc agccacacgc
81841 acRaatctct tccaggcttc atcgctagtc agcaggattt tcagatgcac tgggctaact
81901 ttcttctgga agtattcaat gacttcttca gtgaagcgtt tcttttctag ttggaaacaa
81961 aaaggat aag attggaagaa agtttgctac cacataaatg gcattgagta taaggtggtt
82021 cggtgttaat cctcctgaac cagctgtcac atggggtatt tttgatggag gcaccagtgc
82081 tatagactga attgtgtgcc cYccaaattc aaatactgag gctctaaacc ccagtgaccg
82141 tatttggaga ttgagccttt aaggaagtca ttaatttaaa gggagtcata agagtaggga
82201 cctactccta taggactggt gtccaattaa aagaaaaaaa agagacagat gatctctctc
82261 tctctctctc tctctctctc tctctcacac acacacacac acacacacac acacacacac
82321 acacaccact gtgaaggcca tgtgaggaca cagccctgag gcagcctctg taagccagga
82381 gcagagσcct ccccagacat caaccctgct ggcaccttca ccttggactt cttgcctcta
82441 gaactgtgag aaaatacgtc agttgttgaa gccacccagc ttgtggcatt ttactaaggc
82501 atcctgagaa gagtgattca ccagggaagt gccacgatgc tttgtggagg aaccaatcta
82561 tttcagctga gaatcaccag aaagtgagct ttccaccatg ttttctcccc atgtacggga
82621 aatattccag tgatcgcttc ctcctgccat gtgcctattg tcaaacactt tacaccagtg
82681 tcttcaaaat ctgaattttg acccatcagt gggttatgac aatagttcat tgtgtcaaga
82741 gcagcatttt aaaaagaaaa gagcattgaa aatatcagag tatattgaac atagcaagag
82801 tgagtattct tttgtaagat acttgaaata taYctataga cccttatgta aattcctggg
82861 atctagatgt gtttaggatg gcagcatttt caatcttcta gaagggacag agggtgcata
82921 tggtttatca ctgaccactc ccagcaggga ctgggcccca ccttgtaatc aaaggtacaa
82981 atgtttcaac caggaaacca atgaatattc accttaagtg gcatacat aa tattatcact
83041 acaaagcatc ttagtacaca gcaggattac tgcccagatg agttgcccca aaaatgtgtg
83101 gtttgcaggg atttgggaat tatggaactc cagagaaggg gctgggaacc agtttgtatt
83161 tatgtatgca ctgggacatg atgtataatt gtttcctgct gtgctcatac gtgcgaggcc
83221 tcattctcat ttcacagaag gagaaattga gacccagaca gcgagagaca ccacccaacc
83281 cagcaagcag gaagctcagg atttgactca aggccagcgt tcccttgcca ttactttgaa
83341 gactccatat atttaaaaaa tgcctgtggt ttctgcattc tcccctgtag tatacctgtg
83401 gggttttaaa cattttattt gcacagagga ttcctcctgc tggtcatggg ctctctcaga
83461 Ygggcagtgg agggggttct ttaggtgggc aggggagtgg gaccctcagc actgatcctt
83521 gtggccσctc cgtgttgcct ctgtcccctg caggctggtc tcagggtaca cggctcccca
83581 ctggcacctc tgaacccagc tggccccgtt agtaaaccac agaYcatσtt gtttcagagg
83641 gagagc tct tccttggccS cccagcccag cccttcctaa ggattctggg attggctgag
83701 WgctctcRgc ttctaatctt ccctgccctc ccctcatctt ggacaggact cagcacagcc
83761 cagtttgctg tccagggcgg cYcctgagca gagctgactt ggttgccatg gcaactctgt
83821 aaggggagga agccctcctg aggaaatggg gcttagggaa atgaacgcag tgctgacttg
83881 gctgggcgag ggattgtctt gttttttctt tttccttctt caccaaaagg aggaaggaaa
83941 ctcagggttg gatggaggga acctccagca ctaaatttgt gttttattga tggggtgggg
84001 atggtgaata ttaaagcaaa attaaaataa aaaccagacc tgaaacattc ccgggcaaac
84061 aaaacc acc agaccttcag aacagctgta accccccatg aaactgcaag ctatgaatct
84121 gaactggggt catatcagat gggcgcttct gtcagacaca aacacagctt aacctcggcc
84181 agtcat agc agccagctga cagagggcca tgctgagatg tggatactgg gaggtcacag
84241 aaaga caag aactccaggc agcaggttca cataatggac acagaaggag ctgctgtaac
84301 cagctgtagg gacaggggga ggggatgggc ccagaggacc ctgacaaaca ggaagtggcc
84361 aatctggcta agaccagtaa gatctaactc agcactgggt ctgacccacc tttcacccca
84421 gactcaatca taccctcctt gtcccacacc cacctgtgcc acagaagttc catgcttgca
84481 acaaaactgc gtggcccccc agttccaaga aatccccgcc tcttcccata aatccttatg 84541 cttactctgc cccttaactt agtaaaccca caaagtcaga aaccccaaac cccactgggc
84601 ccgactggct cttctgagtc cgcctgcact cccacccctg agcctgcgct tctgctttgc
84661 aataaaagct aatttgcttt ggctttgcct caaattcttt ctctcttcgt tgtcagaatc
84721 ctggacaagg ctaaggtccg gtctcacctg cattcagaga cctccctaaa cccaccggca
84781 tcaacatgac caggaatttt ccaacaaggt aaagcaaaac aggcagtttt atcactggaa
84841 ctaatcaaat aatgtcctaa ttgcacttcc atattcaccc gataaacact tgtcttccac
84901 agtttttcat cataacacaa aacctcctcc agtttggttt tctctattta tgaactcctt
84961 cttattcaga taaatgttgt tgtgcctcag atgtttcttt gacaaggggt actttcgatg
85021 attggactca gcccagataa agaggtgctt gtgacaggca gtgcagggtg ggtgccctaa
85081 cacagctcgg gaagggggtg gcttccactt acaatcaaca ggggtcaggt agaggggatg
85141 ggaaccaccc cttagggagg ccgtactgtg tggcaggcac tggctggccc aggtacccat
85201 gtaatgtt tg atcctcatga caacatgggc aaatatccta gtggtgcagg tgaggaggag
85261 taaggagctc caggtcacac agaggggaca tggccaagac cagaatgggg tccagttcag
85321 tgggaagctg ggtcactcta cccacagggc cactcagagc agaggggctg gtgcagggca
85381 agagctggag ggaggggacc ggcctctgct ggaaacaccc cagggtcagc caggagcaga
85441 gagggaggtg agaggtcagg gctgctggtc aacctcctct cccacccctc cgctactcct
85501 ggccaaccct caaaagccaa ccctgctgtt tccatttccc caaggctgtc ctgccccact
85561 taagtcat tt gctaggtgtc agggtaggga ggaagtgggc acctgggcca tgacccgctg
85621 aggagaggtc aggatgcaga tgccccccag aaccctgggt caggggactc cacgtggcct
85681 ctcttggggc ttggggcagc ctcatcRgcc acctccRtct gggttccgtt ggggctcact
85741 cagccttgaa gacaccaccc tccattctag ctgtgggtag gaaccagcca gggaagagga
85801 ggcgagcc ta ccagcagcca ggtctctgaa aggcttacct tggaactgtc cagccactgt
85861 ccagcctgga tggttttgct gcacccttga ggaagagaaa acaaattgtg ggattgaatg
85921 tgagccacct atgggcaaag ggaggcttga acagctgggc ctctgcagat ccctctgagg
85981 tggcagcaaa tgccaagacc aacctaaccc agattctttc tctatcacca agtccccatc
86041 atctgctatt tacagacact caactcattc cagctccctc ttccctcact ctcacaccaa
86101 ggaaaagt cc gcttgtcctg ttggagaatg aggagaagat aatcagagga ggggcagcca
86161 tctgatcatt acagaaacta cacagtctat acgcagaaat agagatggga aggaacgttc
86221 taacaatgac cggaaacatg tgtgacaact aattgatgat agccagtctg tattgagtgt
86281 ctgtgatgtg cagggcttct ttttttattt ttatttttat ttatttatat tttttgagac
86341 ggagtctcgc tctgtcgtcc aggtggagtg cagtggcgcg atctcggctc actgcaagcg
86401 ccgcctccca ggttcacgcc attctcttgc ctcagcctct cgagtagctg ggactacagg
86461 tgcccgtcgc cacattcggc taattYtttg tattttcagt agagaagggg tttcaccgtg
86521 ttagccagga tggtctcgat ctcctgacct catgatcagc ccgtctcggc ctcccaaagt
86581 gctgggatta caggcgtgag cggtcgcgcc gggcctgtga tgtgcagggc ttctgacatg
86641 tgtctcattc aatgatcaca cacagcccgg gagatgggta ccactttccc atttgaacac
86701 agaggaatcc acaaaagtta gggaacttgc cagtgttttc tattgctaga gccaggactt
86761 ctgcttcaac ctcatgtctt caatgactgt gctctactcc cttaaatata caatattgag
86821 tcatgtatac acRctcatgg taaatgactc ctcattgcaa atccatgtct cacactccgt
86881 gctcaacttt tcgtcttggt gaattcactg gtgctgcagt ggacagcctg tgtccccctt
86941 gcttctctaa gatcctttgt cccacaaaga cctggatcct gccagatgcc ggcctagccc
87001 ctgctgtggc tgccgagccc tcctggcgct gccctgttcc ctctgctgtc ctcccctagc
87061 tgatggacct tagggtgttt ctaattcttc atgtaaatta tgctacaaag aacaYcctcc
87121 ttcacgtaaa actgcccaca tttgatttta tttccttaag atatttgtag gagtagaatg
87181 actaggtcag agggtatcaa catctcaaaa tgttttatac ctagagccac actRcatgca
87241 aattgtacca attcacactc aaactagcag tatatgaaga tgcccattct ttcagtctta
87301 ctggctctca gtagtctctt tatcaggaca aaaaatatat acacaacatg taaatttgag
87361 aactaaat t cttgttatca ataccaatta gtacaaactt taaggcacga aggtagcagt
87421 tgagatgtga agcactgaac aaaggagaag gaggattaat attgtcattt tttaaagaKg
87481 gaagttaaga aatactgggt acaactgagg gtataagaaa gttgtaagta aattgtttac
87541 agctacaaag ttgctaatgg Ragacataaa actggtgata gaatgttagg aaaaggtgga
87601 gagRagagat agagggaggg tacaaataag atgaaaatga ctaataatga tactataaat
87661 aataacaata ccaYttcagg cccatcccag ttaggggcgg ctccaagcat taccattgtt
87721 cttttctcac cgtgtgtctc tgcgcactcc ctggcacacc cacttccagc agctggtctt
87781 tgtttgcaga ctttatttta acagctcagt ggttcccggg ccccctgatg gggttccatc
87841 ctccagctct catactaaag ccccctcctc aaaagccact cgcctccctc tttccctttc
87901 ctgcctttgt ctcagggttc agacacacag atgtctgtct tctggggccc ccatgcaRca
87961 agggtaaaag ggggacccag tcctgggcag cNttcaccag gggagtatgc agaggggcRt
88021 ctgggcgctt cttgctgtaa gggacagggg tgacaggaga ggggcatccc ttcSccttSt
88081 tcctgctttg ttcactgtgt gaccccctag gccaRggSaR ccatctcaac accaNgagcc
88141 aKKagaacjNg ggaggaccag gagagagcag aggagcagga gggcagagag ctggggcctc
88201 ggactcaccc gacgcttgtg atgagctgca cccaggatcc catcctcctt ggtcattgtt
88261 ggcctggctc agacgctgat ctggggcctc tgctgaatgt tgaggctgga tactgactgt
88321 tagcctcaac taggacacaR tgcKtcccct ctaggcgagt ctaccagttg gtcaattccg
88381 ggaagtgatt ttggttccta gaaaaaccca catggctcct ggcccagccc aagccctgcc 88441 caattgtgca gcccagacag ggagccctcc ctcccacctc agggctctga gccaagctca
88501 ccagatgcag aSgacaaaga Ytttcagcaa agcagctccc tccatgtcgc tgcggggcct
88561 cctccttggg caggaaaaga ggggttgaga cagtgtgctc ctcctgagaa atcaccattt
88621 tcatttcatt tttaataaac cgttttgctS tgtcacccag gctgcagggc tttgacgcca
88681 tcctagctca ttgctgccta gatctgctgg gctcaagtga tcttcctcct tcaaccttct
88741 gagtagctgg gactacaggt gcacgctacc atgctgggct aatttgttaa tttttgattt
88801 catagagaca gcatctcctg tgtttcYcag gctgtcttga actcctggcc tcaagtgatc
88861 ttcccgcctc tgcctcccac agcactggga ttacaggctt cagctatagt gctttctatc
88921 ttgatgggca tctctttttg gtgaagaaaa atcaggccgg gagcggtggc tcacgcctgt
88981 aatcccagca ctttgggagg ccgaggcagg cagatcacaa ggtcaggaga tggagaccat
89041 cctggctaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc cgagtgtagt
89101 ggcgggcgcc tgtagtccca gctactcggg aggctgaggc aggagaatgg tgtgaacccg
89161 ggaggcggag cttgcagtga gcagagattg cgccactgca ctccagcctg ggcaacagag
89221 cgagactccR tctcaRaaaa aagaaaaaaa aaaaaagaaa aagaaaaata agaccacgac
89281 tcagatttca cagaaattac ccccctgatt tcatggactt ttggcagctc tatcaggttt
89341 ctgagagggg aaaatcttag gctgggaggg gaggtgactt gcccagagtc gcacagctct
89401 tggagagcag acgggaagcc aacatctgcc cttgtgactc tgctattgaa gaaaaacggg
89461 tgattttagt aatcaaacag tgtccaggtt tgattctgct tctacaaaca cagagatcta
89521 agctctcact cctgtagtta cactcacaat tccacaggtg gcttttgaat ctcatgatta
89581 caaagctggc gtcatgccac aggcaccatt ctgcaatgcg accttctcac tcccctgtct
89641 cagccatgtt tcctattgcg ggatctggcc agcagccccc agtgcaacgg ggctctctct
89701 ttgctcctag gcggatcggc aggttgagaa ataatagaca cacacaagat agtgaaagct
89761 gggtccaggg gggtcaccgc cttctggtca acaatgcact ggatatacca gcatttatta
89821 ttcagtttag tgagggcggg ggtaggttag tgagggattt agggtcattt gattacgagg
89881 tgggatggtc acatggggat gaagtaattc tttaacataa cattcgtatg tagaagtaca
89941 gtgcatttgt atgtagaagt acagtataca gagataagaa tttacaatat agtgtgtgcg
90001 tcagtaattt ctaacagagc cttaaaacag aaacacaatc tttccataac ctatgattag
90061 caagatatta atcagcagta acaattgcaa caaaagctgg ttactgacaa tccatggaaa
90121 caggacgtga agctagataa ccggttagac tagaaattct cagaagggag tatacctgaa
90181 ccctaaagat gcctagaaga gccacggcaa gatgatagca tttatagccc tagcttgtcc
90241 atatggacag gcgcccccct gcatccattc ataggctctc tgcaggggga agcacatcac
90301 gtgctgttgg ttcgttctgg cagtccaacc tggcattgtc tttacacaat cctgcatgca
90361 attttgtatt tacaataatc aggagcattt catcttttat tccgtagcaa tagtttcagg
90421 gggtctccct acagtttccc attagggaca cagcacagcc tgtttcttct ccatcacccc
90481 agaggtctga acagagggac agaggtgagg gccacagaca tggagtccta tgatctacct
90541 gctcagcctc ctgacactgg accctgggca agtcactccc ctcccagggc ctcagtttcc
90601 ccacagggcc tggcacaagt aggtgctcag actcagggtg ggtgagatga cctctaggtt
90661 ccttgtatct caaaagaaat ctcttgcctc atcaggcctc agcagccgca ccccggggcc
90721 agcctggttg tggccagacc ataaggacag accRggctcc aggtcacctc cccacctcca
90781 ccttctttga ttccttcaaa tttcccaaag agatgggcac ccccaacaca aaccttcctt
90841 ctggggtcac ctggccatgt ctcagcagtc taaaacagag ctgagcccag agagctttgt
90901 gaacccatct gagctatttc cccacctctc tctacggttt aagggcccag caggagggag
90961 ggagcaatca gactcaagcc tgg- tgcaaa tcccggctct accactgctt tcctgtctga
91021 tctgaacgag ttacctaacc tctccgagct tatctacaaa agctgaatga tccttccctc
91081 atagagctat tgcgagaata aggagatggR gggaggtcac accatcccca acttaccaag
91141 ggatcttcct ctgacagaga ctgagcaaga tccagctggt ctgagctgtg tggatctcac
91201 ctccagctgt gcacctatat aataaccaga cacgtcctcc agcccccaag atatacccag
91261 gaattcgaaa ggtaaaatga aa tcacaac ttcccagcag ctcacaatca agcacagcaa
91321 acacgctgct ccccagcacc tc tgcagtc cagccccacc ctccttgctg ctgcgcttag
91381 aggagcagcc tgagaccaga cct ccaggtc tctttcatcc aacccacctg cctggcatcc
91441 tcggggttgg gggtctgcta tag cttcag gaagaaagac ctgccactga catactgtgg
91501 gacccttcag attactcccc gtσctcccgt gcttccacat tcccctgatg cctgccttac
91561 tcctgcccat accatcagca tttgcacagt ctcctacaca tgccaagtgg atccttattg
91621 tatatttatt gtaaggccat tggggttatt ttggttttgt tctggagaca gggtctcact
91681 ctgtagccaa ggctgaagtg caccgccaca gtcatagtgc actgcagttt caaacccctg
91741 ggctcaagcc atcctcccac ctgagcctcc tgagtagctg tttctacagg catcagccaa
91801 ccacccagct aatttttaaa aaagttatat tagagatggt gtctcactat attgactggg
91861 ctactcttga actccaggcc tcaagtgatc ctcccacctt ggcatgagcc accgcaccag
91921 gcctgctctt gttgaaggcc atggcttgtg gcttctagat atttgcttat gtggggtctt
91981 ctgccgggat cccctgcttc caccacctgg aaaaatcatg ctcatYgttc agtgacaaaa
92041 tcaggcattg cctcctgtca gagatccccc agcatcctcc caagcagagg ccactgcccc
92101 gtgttccact cccgaggcac acagggtgga gggactagag accactgctc agccacactt
92161 ctatggctaa gaagtcatgc aaccagattg ctattggact tttgtgcttt gccccaggca
92221 gaagggcctc aaagacagct gaacctcaga agccaacctg acccttccat gggggcctat
92281 ttcatcctga gcaaacatcg ctgggggcat cgtggccacc tccccccacc catacgcaca 92341 cacaccagct tttgagacag gaacagaaag gtgattacac agggactgca caatacactt
92401 tgcaatacat tccatttgca aatgcttctc catttgattg aattttataa tcatcccctc
92461 aatgggccag gattatgatc taagttttca aatgaggaaa ctgaggcaag gggcgaggaa
92521 gttgctttca tccagcaact cagggaggag ccaagacttg tcaaccaaag agggtctggg
92581 acacgtctca gtcagtttag aggtttactc tgccaaggtt gaggatgcac ccaggaaaaa
92641 gacacgcaag tcacaggaag atσtggggcc cactcattat tcccagaggg ttttgagggc
92701 ttcaacattt aaatgtgtaa aatcaggcag gcgtggaagg agggaaggaa aaaagacagg
92761 ataggtaatg agctgagtgg tcacattttt gtgaggcttt gatcggccct ccctgaatcc
92821 ataggttcca tgtgaaaggg ggttagagga acagtccatt attcattctt cttgtgcaca
92881 gttaatctac attttctata agataaaaat aaacagaaag tagaggaagt aggcatatgt
92941 gcatttgtct gagYgtgggc agaagggtca cttccactct tgtcattgtt aggtaccagt
93001 caagataagt tgccagtttg cat gtcaca gtgaaattat acaaagtctg tctcagggtg
93061 aaaatttggg gacctacaag gattttcttt gtgaggaatt tgtgaggcag gccaactggg
93121 gtatatgttg ccttccatct ttgcaaatat ctgtttagaa acaaaaacaa aggcaggttc
93181 tggagtgact ctgtttccag gcttaactgg ttccactggt atagtgaatt tggggccctg
93241 agatttgatt ttcctttcac attttctctt tgtttttcaa tatcttttgg agaaaacagt
93301 gtagaagcaa aagaatctcc agtcacgggg ttggtctgaa ttctgtaaca caaagtattc
93361 caccttccgt ttgcNtgcag gggtttagaa aaaggacagt tttgatttct ggtgatgcca
93421 agtcagaaaa atgagagaaa aacaaaagga atatgttagt ttggagactt gtagccagga
93481 aagaattcaa tatctagtgc ggataaattg tagacaaata ataaagctgg aaaacaatgg
93541 acaaagctag aatctcataa cagacgtttt atagtttctt ttaaaacaca ttttctctct
93601 ctagtactct atttctacca aagacaaatc atagtaggac gcatttattt gcaaaataag
93661 ttttagtctt ctaatacttg gcσtgattat ttgcataaag tgcagaagaa taatcttgtg
93721 gcataaggag tcttttttaa aatttgactt tgctaggcca ttttcgtatt cataagctat
93781 ctcagagtag gccYtttaaa accttgagct cagccacgaa tttatgtttg cctgcagata
93841 cctgtatgaa ttgggtgagt tcσtttcttc tcgaggcccc atgatcactt gggcttcctg
93901 ggcctgtcag aaagtgatat tctttattta ccacagttca ggaaccctgt aaaggaactc
93961 tataggcaaa ggacttaata aaggactgaa attaatttca gtcctttagt aattcagtcc
94021 catgtaatta ccttcttcca tttgatattg gcttagcaac cttcctgaac acatcagctt
94081 tttttttttt tttccagttt tgctgtcagg gcccagggga gggagaataa ggagttatgg
94141 cttgctggat acaaagtttc cattttgcaa gaagaaaagt tctgtggatg atagcggttg
94201 cacaacaatg tgaatgtaat tccactgaac tgtacaccta aaaatggtta aaatgatcaa
94261 ctttaggtta ggaatatttt accacaattt aatttttgtt tgtttgtttg tttgcttgtt
94321 tgttttgaga tggagtcttg ctctgtcacc caggctggag tgcagtggcg caatctcggc
94381 tcactgcaac ctccacctcc caggttcaag caattctcct gcctcatctt ccccagcagc
94441 tgggactaca ggtgcatgcc acσacgctca gctaattttt tgtattttca gtagagacag
94501 ggtttcacca tgttagccag gatggtttca atctcctgat gttgtgatcc acctgccttg
94561 gcctcccaaa gtgctgagat gacaggagtg agccactgca ccaggcccaa ttaaaaaagt
94621 ttttaaaatc cttgaaaacc cacctttgca gaaaaaaaaa taatagcacc tgagcctttt
94681 ctggtttgct aaacattttt acacacataa tcatacaagt ttcaacaaca gccctgtgat
94741 gaaaacattt tcttcctagc ctcgtttccc agaagagaaa acaaaggttc aaatggggtg
94801 aaatgagtta ctcagaaaga ggcagagctg ggcttgtagc tggacctttc tggttcttgt
94861 tttgtttcat tttctggacc atcctgtttc ccctaaagga aatgatttcc tgaaatttct
94921 caagtattct gaaaatstaa ttttcttcct cactttctcc ctgttggctc aagatgaatc
94981 acaaaactcc aaataccatc agaatgtgtt gcccaagtcc cacctgttct atggctgatg
95041 gccacaggga gctgggtatg gctgggcYgg ttatgaccaa ctgtaacccc atcaaggatt
95101 aacatgctcc tgaaacagac cccatgtcca gaaatttgca aaacctaccc tgaaatgttg
95161 acatcataga gtgtgcccca atgtcctgtc cagatttctg tccctcccat gagctggaga
95221 ggatatttgg catcagacag ctggaaatca ctttccccag tttttggctt catgactcag
95281 ttttcttgct tgtagaataa agctaatcat agaatttacc tctcagaatt cctaagagaa
95341 taaattcagg cagggtgggg aatatgcatg gcatatagta gatgctcatt aaacaagaat
95401 caatatttct gagcactcac tctgtataca gggcagtgag caatcatgat gtctgcatta
95461 tctccatttg taactgaaga aaagttcagc tgctcactgc ttgcaaaggc aaatgaacaa
95521 ggatgagaag cagtgaaagg aaagtgactt cattccaaaa gcccatatct ggggatgagg
95581 tcaggctagt gccttagaga aaccatttca gattttgaac tgagggcagg tgtttcaaaa
95641 gggaaacttg atatgaaagg catgcaagag tggtgaagaa gtgccagtct acatgacttg
95701 tccaatgacc atcttgagtt attgccccat cgggtgtatg gactggggac atctccagga
95761 tagccaggtt gaaaattcaa tgtagccttg aggcaattct gtagcttcct ggatggtttc
95821 aagatttctt ctactggggg aacacactcc caacatttca atggaggttc tttctatttt
95881 ccataaatgt tggccagctg agaaataaag agagacagta caaagagagg aattttacag
95941 ctgggctgct gggggtgaca tcacatatca gcaggactgt gatgcccacc tgaatctcag
96001 atcagcaagt ttttattcag ggttttaaaa aggggagggt gtgtaagaac agggagtagg
96061 tacaaagatc acatgcttca aagggcaaaa agcagaacta ctaataaggg tctaacaaag
96121 atcacatgct tctgagggaa caggacaaag ggcaaaagca gaaatactga tatgttcagc
96181 ggtgcacRta ttgtcttgat aaacatctta aacaacagaa aacagggttt gagggtagag 96241 aaccggtctg accacaaatt taccagggtg gactttttcc ccaccctaat aagcctgagg
96301 gtactgcagg agaccagggc atatctcagt ccttatctca accgcataag acagacatcc
96361 ccagagcggc cgtttataga cctcccccca gaaatgcatt cctttcccag ggtattaata
96421 ttaatattcc ttgctgggaa aagaatttgg caatatcttc cctacttgcc catctgttta
96481 taggctctct gcaagaagaa aagtatagct ctttttgccc gaccctgcag gcagtcagac
96541 cttatggttg tcttcccttg ttccctaaaa tcgctgttat tctgttcttt ttcaaggtgg
96601 actgatttca tattgttcaa ccacacatgt tttacaatca atttgtacag ttcacataat
96661 tatcactgtg gtcctgaggt gacgtacatc ctcagcttag gaagataaca ggattaagag
96721 attaaagtaa agacaggcat aagaaattat aaaagtatta tttgggaact gataaatgtc
96781 catgaaatct tcacaattta tgttcctctg ctgcggctcc agccggtccc tccattcggg
96841 ctccctgact tcctgcaaca tcttccctgg aatttctaag caatctaaca tgattaaata
96901 aaatacagtg catgggaggg gagttcctag tagaaaagga gaacaaagat tcacacatta
96961 ctaaaagcaa aacaagaaat ggacaaagag aggagaccag aaacaaacaa acaaaaaata
97021 aaatgggata cttggttaca ttttcatctt ctccatgcac tctctagtac tcttgatgtt
97081 tctcctatcc cYatgtacag accagaaaca gactcagaaa ataaaatcat ttccccaagg
97141 ccacacaact ggccttggct tccttttttg ttagagacag gatctcactc tgttgcccag
97201 gctggggtgc agcagcagat caaacgtctg ggctcaagtg atccccccac tgcaggaacc
97261 caagcagctg aaactacagg catgtgccac catgtctggc taatttttta actttcttgg
97321 tagagatgag gtctcatgat gttgcccagg ctggtcttaa actcctagcc tcaagtaacc
97381 cttctgcttc agcctcccaa tgtactggag ttgtaatcga gtaacccagc attgaaatgt
97441 actttaacat tatttttctt tctgtcttaa tctcagaatg tagctttaaa atgtacttca
97501 aaattccttt cccctccctt tctcaccaag ctctcttgtg cacagtgctc acttatctaa
97561 tgatgtgggt gcatagaaat tcaaggagtg aattttgaaa aaaaaacagg cagagaaacc
97621 caggtgcaaa attctccggc ttagggggag ttaccaacaa ttaatccacc accaacaggg
97681 taaagtccaa atgatgccaa ttggacctcc tgacgggcta cttctcaaga cagccattgg
97741 aacaagacac agacctgcac cctcctgcac cactcccaca cacctccaat tccaattttc
97801 cctttctaaa cccctctctc cagcctaaag tagaaatgat cttttaagag catgagcctg
97861 atcattcccc cactgtgagc acttgaatga agctgctttc ccttcaccgc aactcacttc
97921 ctgtgttttt ggccactgag tggtgagcag ctggacttga gccagttata gcattacagg
97981 agggagccaa tgcacccagc atggcttccc tttttcacct actgatcctc acgattcagt
98041 gcttaaatta tagaaatttt ttcatttcta agacaaataa tgatagactc acaagacaaa
98101 acagcacagc tggaaaaata gttgcaaaac tagcacagag aggccctgca gactctttgc
98161 ccagtttccc ccaacggtcc tccagttcat ctgatgtagg agctggactg ggctggtctg
98221 gaaactcagt ctcagctgcc tgaagtggtc acttatccat gcgctccctt agaggggatg
98281 acaaggtcct aggagaagtc aacatcaaag ccacctccaa gctgtggtca gcccaaagga
98341 gatggtcaca aaggcagaat tcagaaggag gaagagactt agagccaagg gtggagatgg
98401 aacctagggg tgggccttga gttacttagg tcaccgatgc caagctgcca taacaaagag
98461 ctcccaatta ccgatatatt caatcaatga tataggagat tgctgaactg agacattcac
98521 accaacgttg ctaggcagtt tcagtggcag gtggttttgc tcccgaaggt cgaccagggg
98581 ttgccactca gagggagttg ttgttttcca cgtggaagct ggcgcttacc catacatccc
98641 agcccaaaga acagaagagg acacaaaaca caggaatctt ccccttaaga gaaacaccta
98701 caagttgcag acatcactgc tctcaccttc cattggccac aatttaggaa gaagacccca
98761 tggagttgcc agggatactg ggcagtcctg tgcctgtgga aactcagcag cYtgatgatc
98821 aaagacgaaa aaaaagagag gaaataaaaa cgggtaaaat gctcaatttt ataactttta
98881 aattttcatc ttttgccacc tggagaacct gaaatggaaa cgaaaagtca caacttctca
98941 gcagctcgtg atcacgcaaa cccactaaac acactgctcc ccggcaccac cttcagcccg
99001 gtcccaccct ccttgctgct gcacttacag gagcaacccc agacccagtg
[0346] Following are cDNA sequences for PADI2 (SEQ IDNO: 14), APOB (SEQ IDNO: 15),
IL1RL2 (SEQ IDNO: 16), ILIRLI (SEQ IDNO: 17-19), WASPIP (SEQ IDNO: 20), ADAMTS2 (SEQ
IDNO: 21-22), BVES(SEQ IDNO: 23-24), TM7SF3 (SEQ IDNO: 25), PELI2 (SEQ IDNO: 26),
LOXLl (SEQ IDNO: 27), CASPR4 (aka CNTNAP4) (SEQ IDNO: 28-29), GPR50 (SEQ IDNO: 30), and APOL3 (SEQ IDNO: 31-36).
PADI2 cDNA sequence fSEO IDNO: 141
NM_007365 Homo sapiens peptidyl arginine deiminase,typeII (PADI2), mRNA 1 cgcacctgct gcaggtgctc ccggccgccc cggaccagcg agcgcgggca ctgcggcggg 61 gaggatgctg cgcgagcgga ccgtgcggct gcagtacggg agccgcgtgg aggcggtgta 121 cgtgctgggc acctacctct ggaccgatgt ctacagcgcg gccccagccg gggcccaaac 181 cttcagcctg aagcactcgg aacacgtgtg ggtggaggtg gtgcgtgatg gggaggctga 241 ggaggtggcc accaatggca agcagcgctg gcttctctcg cccagcacca ccctgcgggt 301 caccatgagc caggcgagca ccgaggccag cagtgacaag gtcaccgtca actactatga 361 cgaggaaggg agcattccca tcgaccaggc ggggctcttc ctcacagcca ttgagatctc 421 cctggatgtg gacgcagacc gggatggtgt ggtggagaag aacaacccaa agaaggcatc 481 ctggacctgg ggccccgagg gccagggggc catcctgctg gtgaactgtg accgagagac 541 accctggttg cccaaggagg actgccgtga tgagaaggtc tacagcaagg aagatctcaa 601 ggacatgtcc cagatgatcc tgcggaccaa aggccccgac cgcctccccg ccggatacga 661 gatagttctg tacatttcca tgtcagactc agacaaagtg ggcgtgttct acgtggagaa 721 cccgttcttc ggccaacgct atatccacat cctgggccgg cggaagctct accatgtggt 781 caagtacacg ggtggctccg cggagctgct gttcttcgtg gaaggcctct gtttccccga 841 cgagggcttc tcaggcctgg tctccatcca tgtcagcctg ctggagtaca tggcccagga 901 cattcccctg actcccatct tcacggacac cgtgatattc cggattgctc cgtggatcat 961 gacccccaac atcctgcctc ccgtgtcggt gtttgtgtgc tgcatgaagg ataattacct
1021 gttcctgaaa gaggtgaaga accttgtgga gaaaaccaac tgtgagctga aggtctgctt
1081 ccagtaccta aaccgaggcg atcgctggat ccaggatgaa attgagtttg gctacatcga
1141 ggccccccat aaaggcttcc ccgtggtgct ggactctccc cgagatggaa acctaaagga
1201 cttccctgtg aaggagctcc tgggcccaga ttttggctac gtgacccggg agcccctctt
1261 tgagtctgtc accagccttg actcatttgg aaacctggag gtcagtcccc cagtgaccgt
1321 gaacggcaag acatacccgc ttggccgcat cctcatcggg agcagctttc ctctgtctgg
1381 tggtcggagg atgaccaagg tggtgcgtga cttcctgaag gcccagcagg tgcaggcacc
1441 cgtggagctc tactcagact ggctgactgt gggccacgtg gatgagttca tgtcctttgt
1501 ccccatcccc ggcacaaaga aattcctgct actcatggcc agcacctcgg cctgctacaa
1561 gctcttccga gagaagcaga aggacggcca tggagaggcc atcatgttca aaggcttggg
1621 tgggatgagc agcaagcgaa tcaccatcaa caagattctg tccaacgaga gccttgtgca
1681 ggagaacctg tacttccagc gctgcctgga ctggaaccgt gacatcctca agaaggagct
1741 gggactgaca gagcaggaca tcattgacct gcccgctctg ttcaagatgg acgaggacca
1801 ccgtgccaga gccttcttcc caaacatggt gaacatgatc gtgctggaca aggacctggg
1861 catccccaag ccattcgggc cacaggttga ggaggaatgc tgcctggaga tgcacgtgcg
1921 tggcctcctg gagcccctgg gcctcgaatg caccttcatc gacgacattt ctgcctacca
1981 caaatttctg ggggaagtcc actgtggcac caacgtccgc aggaagccct tcaccttcaa
2041 gtggttgcac atggtgccct gacctgccag gggccctggc gtttgcctcc ttcgcttagt
2101 tctccagacc ctccctcaca cgcccagagc cttctgσtga catggactgg acagccccgc
2161 tgggagacct ttgggacgtg gggtggaatt tggggtatct gtgccttgcc ctccctgaga
2221 ggggcctcag tgtcctctga agccatcccc agtgagcctc gactctgtcc ctgctgaaaa
2281 tagctgggcc agtgtctctg tagccctgac ataaggaaca gaacacaaca aaacacagca
2341 aaccatgt
APOB cDNA sequence fSEQ ID NO: 15)
NM_000384 Homo sapiens apolipoprotein B (including Ag(x) antigen) (APOB), mRNA 1 attcccaccg ggacctgcgg ggctgagtgc ccttctcggt tgctgccgct gaggagcccg 61 cccagccagc cagggccgcg aggccgaggc caggccgcag cccaggagcc gccccaccgc 121 agctggcgat ggacccgccg aggcccgcgc tgctggcgct gctggcgctg cctgcgctgc 181 tgctgctgct gctggcgggc gccagggccg aagagg aat gctggaaaat gtcagcctgg 241 tctgtccaaa agatgcgacc cgattcaagc acctccggaa gtacacatac aactatgagg 301 ctgagagttc cagtggagtc cctgggactg ctgattcaag aagtgccacc aggatcaact 361 gcaaggttga gctggaggtt ccccagctct gcagctt cat cctgaagacc agccagtgca 421 ccctgaaaga ggtgtatggc ttcaaccctg agggca agc cttgctgaag aaaaccaaga 481 actctgagga gtttgctgca gccatgtcca ggtatgagct caagctggcc attccagaag 541 ggaagcaggt tttcctttac ccggagaaag atgaacc tac ttacatcctg aacatcaaga 601 ggggcatcat ttctgccctc ctggttcccc cagagac aga agaagccaag caagtgttgt 661 ttctggatac cgtgtatgga aactgctcca ctcactt tac cgtcaagacg aggaagggca 721 atgtggcaac agaaatatcc actgaaagag acctggggca gtgtgatcgc ttcaagccca 781 tccgcacagg catcagccca cttgctctca tcaaag cat gacccgcccc ttgtcaactc 841 tgatcagcag cagccagtcc tgtcagtaca cactggacgc taagaggaag catgtggcag 901 aagccatctg caaggagcaa cacctcttcc tgccttt etc ctacaacaat aagtatggga 961 tggtagcaca agtgacacag actttgaaac ttgaagacac accaaagatc aacagccgct 1021 tctttggtga aggtactaag aagatgggcc tcgcatt tga gagcaccaaa tccacatcac 1081 ctccaaagca ggccgaagct gttttgaaga ctctccagga actgaaaaaa ctaaccatct 1141 ctgagcaaaa tatccagaga gctaatctct tcaataagct ggttactgag ctgagaggcc 1201 tcagtgatga agcagtcaca tctctcttgc cacagctgat tgaggtgtcc agccccatca 1261 ctttacaagc cttggttcag tgtggacagc ctcagtgctc cactcacatc ctccagtggc 1321 tgaaacgtgt gcatgccaac ccccttctga tagatgtggt cacctacctg gtggccctga 1381 tccccgagcc ctcagcacag cagctgcgag agatcttcaa catggcgagg gatcagcgca 1441 gccgagccac cttgtatgcg ctgagccacg cggtcaacaa ctatcataag acaaacccta 1501 cagggaccca ggagctgctg gacattgcta attacctgat ggaacagatt caagatgact 1561 gcactgggga tgaagattac acctatttga ttctgcgggt cattggaaat atgggccaaa 1621 ccatggagca gttaactcca gaactcaagt cttcaatcct caaatgtgtc caaagtacaa 1681 agccatcact gatgatccag aaagctgcca tccaggctct gcggaaaatg gagcctaaag 1741 acaaggacca ggaggttctt cttcagactt tccttgatga tgcttctccg ggagataagc 1801 gactggctgc ctatcttatg ttgatgagga gtccttcaca ggcagatatt aacaaaattg 1861 tccaaattct accatgggaa cagaatgagc aagtgaagaa ctttgtggct tcccatattg 1921 ccaatatctt gaactcagaa gaattggata tccaagatct gaaaaagtta gtgaaagaag 1981 ctctgaaaga atctcaactt ccaactgtca tggacttcag aaaattctct cggaactatc 2041 aactctacaa atctgtttct cttccatcac ttgacccagc ctcagccaaa atagaaggga 2101 atcttatatt tgatccaaat aactaccttc ctaaagaaag catgctgaaa actaccctca 2161 ctgcctttgg atttgcttca gctgacctca tcgagattgg cttggaagga aaaggctttg 2221 agccaacatt ggaagctctt tttgggaagc aaggattttt cccagacagt gtcaacaaag 2281 ctttgtactg ggttaatggt caagttcctg atggtgtctc taaggtctta gtggaccact 2341 ttggctatac caaagatgat aaacatgagc aggatatggt aaatggaata atgctcagtg 2401 ttgagaagct gattaaagat ttgaaatcca aagaagtccc ggaagccaga gcctacctcc 2461 gcatcttggg agaggagctt ggttttgcca gtctccatga cctccagctc ctgggaaagc 2521 tgcttctgat gggtgcccgc actctgcagg ggatccccca gatgattgga gaggtcatca 2581 ggaagggctc aaagaatgac ttttttcttc actacatctt catggagaat gcctttgaac 2641 tccccactgg agctggatta cagttgcaaa tatcttcatc tggagtcatt gctcccggag 2701 ccaaggctgg agtaaaactg gaagtagcca acatgcaggc tgaactggtg gcaaaaccct 2761 ccgtgtctgt ggagtttgtg acaaatatgg gcatcatcat tccggacttc gctaggagtg 2821 gggtccagat gaacaccaac ttcttccacg agtcgggtct ggaggctcat gttgccctaa 2881 aagctgggaa gctgaagttt atcattcctt ccccaaagag accagtcaag ctgctcagtg 2941 gaggcaacac attacatttg gtctctacca ccaaaacgga ggtgatccca cctctcattg 3001 agaacaggca gtcctggtca gtttgcaagc aagtctttcc tggcctgaat tactgcacct 3061 caggcgctta ctccaacgcc agctccacag actccgcctc ctactatccg ctgaccgggg 3121 acaccagatt agagctggaa ctgaggccta caggagagat tgagcagtat tctgtcagcg 3181 caacctatga gctccagaga gaggacagag ccttggtgga taccctgaag tttgtaactc 3241 aagcagaagg tgcgaagcag actgaggcta ccatgacatt caaatataat cggcagagta 3301 tgaccttgtc cagtgaagtc caaattccgg attttgatgt tgacctcgga acaatcctca 3361 gagttaatga tgaatctact gagggcaaaa cgtcttacag actcaccctg gacattcaga 3421 acaagaaaat tactgaggtc gccctcatgg gccacctaag ttgtgacaca aaggaagaaa 3481 gaaaaatcaa gggtgttatt tccatacccc gtttgcaagc agaagccaga agtgagatcc 3541 tcgcccactg gtcgcctgcc aaactgcttc tccaaatgga ctcatctgct acagcttatg 3601 gctccacagt ttccaagagg gtggcatggc attatgatga agagaagatt gaatttgaat 3661 ggaacacagg caccaatgta gataccaaaa aaatgacttc caatttccct gtggatctct 3721 ccgattatcc taagagcttg catatgtatg ctaatagact cctggatcac agagtccctg 3781 aaacagacat gactttccgg cacgtgggtt ccaaattaat agttgcaatg agctcatggc 3841 ttcagaaggc atctgggagt cttccttata cccagacttt gcaagaccac ctcaatagcc 3901 tgaaggagtt caacctccag aacatgggat tgccagactt ccacatccca gaaaacctct 3961 tcttaaaaag cgatggccgg gtcaaatata ccttgaacaa gaacagtttg aaaattgaga 4021 ttcctttgcc ttttggtggc aaatcctcca gagatctaaa gatgttagag actgttagga 4081 caccagccct ccacttcaag tctgtgggat tccatctgcc atctcgagag ttccaagtcc 4141 ctacttttac cattcccaag ttgtatcaac tgcaagtgcc tctcctgggt gttctagacc 4201 tctccacgaa tgtctacagc aacttgtaca actggtccgc ctcctacagt ggtggcaaca 4261 ccagcacaga ccatttcagc cttcgggctc gttaccacat gaaggctgac tctgtggttg 4321 acctgctttc ctacaatgtg caaggatctg gagaaacaac atatgaccac aagaatacgt 4381 tcacactatc atgtgatggg tctctacgcc acaaatttct agattcgaat atcaaattca 4441 gtcatgtaga aaaacttgga aacaacccag tctcaaaagg tttactaata ttcgatgcat 4501 ctagttcctg gggaccacag atgtctgctt cagttcattt ggactccaaa aagaaacagc 4561 atttgtttgt caaagaagtc aagattgatg ggcagttcag agtctcttcg ttctatgcta 4621 aaggcacata tggcctgtct tgtcagaggg atcctaacac tggccggctc aatggagagt 4681 ccaacctgag gtttaactcc tcctacctcc aaggcaccaa ccagataaca ggaagatatg 4741 aagatggaac cctctccctc acctccacct ctgatctgca aagtggcatc attaaaaata 4801 ctgcttccct aaagtatgag aactacgagc tgactttaaa atctgacacc aatgggaagt 4861 ataagaactt tgccacttct aacaagatgg atatgacctt ctctaagcaa aatgcactgc 4921 tgcgttctga atatcaggct gattacgagt cattgaggtt cttcagcctg ctttctggat 4981 cactaaattc ccatggtctt gagttaaatg ctgacatctt aggcactgac aaaattaata 5041 gtggtgctca caaggcgaca ctaaggattg gccaagatgg aatatctacc agtgcaacga 5101 ccaacttgaa gtgtagtctc ctggtgctgg agaatgagct gaatgcagag cttggcctct 5161 ctggggcatc tatgaaatta acaacaaatg gccgcttcag gg-aacacaat gcaaaattca 5221 gtctggatgg gaaagccgcc ctcacagagc tatcactggg aagtgcttat caggccatga 5281 ttctgggtgt cgacagcaaa aacattttca acttcaaggt cagtcaagaa ggacttaagc 5341 tctcaaatga catgatgggc tcatatgctg aaatgaaatt tgaccacaca aacagtctga 5401 acattgcagg cttatcactg gacttctctt caaaacttga caacatttac agctctgaca 5461 agttttataa gcaaactgtt aatttacagc tacagcccta ttctctggta actactttaa 5521 acagtgacct gaaatacaat gctctggatc tcaccaacaa tgggaaacta cggctagaac 5581 ccctgaagct gcatgtggct ggtaacctaa aaggagccta cσaaaataat gaaataaaac 5641 acatctatgc catctcttct gctgccttat cagcaagcta taaagcagac actgttgcta 5701 aggttcaggg tgtggagttt agccatcggc tcaacacaga catcgctggg ctggcttcag 5761 ccattgacat gagcacaaac tataattcag actcactgca tttcagcaat gtcttccgtt 5821 ctgtaatggc cccgtttacc atgaccatcg atgcacatac aaatggcaat gggaaactcg 5881 ctctctgggg agaacatact gggcagctgt atagcaaatt cctgttgaaa gcagaacctc 5941 tggcatttac tttctctcat gattacaaag gctccacaag tcatcatctc gtgtctagga 6001 aaagcatcag tgcagctctt gaacacaaag tcagtgccct gcttactcca gctgagcaga 6061 caggcacctg gaaactcaag acccaattta acaacaatga atacagccag gacttggatg 6121 cttacaacac taaagataaa attggcgtgg agcttactgg acgaactctg gctgacctaa 6181 ctctactaga ctccccaatt aaagtgccac ttttactcag tgagcccatc aatatcattg 6241 atgctttaga gatgagagat gccgttgaga agccccaaga atttacaatt gttgcttttg 6301 taaagtatga taaaaaccaa gatgttcact ccattaacct cccatttttt gagaccttgc 6361 aagaatattt tgagaggaat cgacaaacca ttatagttgt agtggaaaac gtacagagaa 6421 acctgaagca catcaatatt gatcaatttg taagaaaata cagagcagcc ctgggaaaac 6481 tcccacagca agctaatgat tatctgaatt cattcaattg ggagagacaa gtttcacatg 6541 ccaaggagaa actgactgct ctcacaaaaa agtatagaat tacagaaaat gatatacaaa 6601 ttgcattaga tgatgccaaa atcaacttta atgaaaaact atctcaactg cagacatata 6661 tgatacaatt tgatcagtat attaaagata gttatgattt acatgatttg aaaatagcta 6721 ttgctaatat tattgatgaa atcattgaaa aattaaaaag tcttgatgag cactatcata 6781 tccgtgtaaa tttagtaaaa acaatccatg atctacattt gtttattgaa aatattgatt 6841 ttaacaaaag tggaagtagt actgcatcct ggattcaaaa tgtggatact aagtaccaaa 6901 tcagaatcca gatacaagaa aaactgcagc agcttaagag acacatacag aatatagaca 6961 tccagcacct agctggaaag ttaaaacaac acattgaggc tattgatgtt agagtgcttt 7021 tagatcaatt gggaactaca atttcatttg aaagaataaa tgatgttctt gagcatgtca 7081 aacactttgt tataaatctt attggggatt ttgaagtagc tgagaaaatc aatgccttca 7141 gagccaaagt ccatgagtta atcgagaggt atgaagtaga ccaacaaatc caggttttaa 7201 tggataaatt agtagagttg acccaccaat acaagttgaa ggagactatt cagaagctaa 7261 gcaatgtcct acaacaagtt aagataaaag attactttga gaaattggtt ggatttattg 7321 atgatgctgt gaagaagctt aatgaattat cttttaaaac attcattgaa gatgttaaca 7381 aattccttga catgttgata aagaaattaa agtcatttga ttaccaccag tttgtagatg 7441 aaaccaatga caaaatccgt gaggtgactc agagactcaa tggtgaaatt caggctctgg 7501 aactaccaca aaaagctgaa gcattaaaac tgtttttaga ggaaaccaag gccacagttg 7561 cagtgtatct ggaaagccta caggacacca aaataacctt aatcatcaat tggttacagg 7621 aggctttaag ttcagcatct ttggctcaca tgaaggccaa attccgagag actctagaag 7681 atacacgaga ccgaatgtat caaatggaca ttcagcagga acttcaacga tacctgtctc 7741 tggtaggcca ggtttatagc acacttgtca cctacatttc tgattggtgg actcttgctg 7801 ctaagaacct tactgacttt gcagagcaat attctatcca agattgggct aaacgtatga 7861 aagcattggt agagcaaggg ttcactgttc ctgaaatcaa gaccatcctt gggaccatgc 7921 ctgcctttga agtcagtctt caggctcttc agaaagctac c tccagaca cctgatttta 7981 tagtccccct aacagatttg aggattccat cagttcagat aaacttcaaa gacttaaaaa 8041 atataaaaat cccatccagg ttttccacac cagaatttac catccttaac accttccaca 8101 ttccttcctt tacaattgac tttgtcgaaa tgaaagtaaa gatcatcaga accattgacc 8161 agatgcagaa cagtgagctg cagtggcccg ttccagatat a atctcagg gatctgaagg 8221 tggaggacat tcctctagcg agaatcaccc tgccagactt ccgtttacca gaaatcgcaa 8281 ttccagaatt cataatccca actctcaacc ttaatgattt t caagttcct gaccttcaca 8341 taccagaatt ccagcttccc cacatctcac acacaattga agtacctact tttggcaagc 8401 tatacagtat tctgaaaatc caatctcctc ttttcacatt agatgcaaat gctgacatag 8461 ggaatggaac cacctcagca aacgaagcag gtatcgcagc t tccatcact gccaaaggag 8521 agtccaaatt agaagttctc aattttgatt ttcaagcaaa t gcacaactc tcaaacccta 8581 agattaatcc gctggctctg aaggagtcag tgaagttctc agcaagtac ctgagaacgg 8641 agcatgggag tgaaatgctg ttttttggaa atgctattga g-ggaaaatca aacacagtgg 8701 caagtttaca cacagaaaaa aatacactgg agcttagtaa tggagtgatt gtcaagataa 8761 acaatcagct taccctggat agcaacacta aatacttcca caaattgaac atccccaaac 8821 tggacttctc tagtcaggct gacctgcgca acgagatcaa gracactgttg aaagctggcc 8881 acatagcatg gacttcttct ggaaaagggt catggaaatg ggcctgcccc agattctcag 8941 atgagggaac acatgaatca caaattagtt tcaccataga aggacccctc acttcctttg 9001 gactgtccaa taagatcaat agcaaacacc taagagtaaa ccaaaacttg gtttatgaat 9061 ctggctccct caacttttct aaacttgaaa ttcaatcaca agtcgattcc cagcatgtgg 9121 gccacagtgt tctaactgct aaaggcatgg cactgtttgg agaagggaag gcagagttta 9181 ctgggaggca tgatgctcat ttaaatggaa aggttattgg aactttgaaa aattctcttt 9241 tcttttcagc ccagccattt gagatcacgg catccacaaa caatgaaggg aatttgaaag 9301 ttcgttttcc attaaggtta acagggaaga tagacttcct gaataactat gcactgtttc 9361 tgagtcccag tgcccagcaa gcaagttggc aagtaagtgc taggttcaat cagtataagt 9421 acaaccaaaa tttctctgct ggaaacaacg agaacattat ggraggcccat gtaggaataa 9481 atggagaagc aaatctggat ttcttaaaca ttcctttaac aattcctgaa atgcgtctac 9541 cttacacaat aatcacaact cctccactga aagatttctc tctatgggaa aaaacaggct 9601 tgaaggaatt cttgaaaacg acaaagcaat catttgattt aa-gtgtaaaa gctcagtata 9661 agaaaaacaa acacaggcat tccatcacaa atcctttggc tgrtgctttgt gagtttatca 9721 gtcagagcat caaatccttt gacaggcatt ttgaaaaaaa cagaaacaat gcattagatt 9781 ttgtcaccaa atcctataat gaaacaaaaa ttaagtttga ta-agtacaaa gctgaaaaat 9841 ctcacgacga gctccccagg acctttcaaa ttcctggata cactgttcca gttgtcaatg 9901 ttgaagtgtc tccattcacc atagagatgt cggcattcgg ctatgtgttc ccaaaagcag 9g61 tcagcatgcc tagtttctcc atcctaggtt ctgacgtccg tgrtgccttca tacacattaa 10021 tcctgccatc attagagctg ccagtccttc atgtccctag aaatctcaag ctttctcttc 10081 cacatttcaa ggaattgtgt accataagcc atatttttat t cctgccatg ggcaatatta 10141 cctatgattt ctcctttaaa tcaagtgtca tcacactgaa taccaatgct gaacttttta 10201 accagtcaga tattgttgct catctccttt cttcatcttc tctgtcatt gatgcactgc 10261 agtacaaatt agagggcacc acaagattga caagaaaaag grggattgaag ttagccacag 10321 ctctgtctct gagcaacaaa tttgtggagg gtagtcataa σagtactgtg agcttaacca 10381 cgaaaaatat ggaagtgtca gtggcaaaaa ccacaaaagc cgaaattcca attttgagaa 10441 tgaatttcaa gcaagaactt aatggaaata ccaagtcaaa acctactgtc tcttcctcca 10501 tggaatttaa gtatgatttc aattcttcaa tgctgtactc t accgctaaa ggagcagttg 10561 accacaagct tagcttggaa agcctcacct cttacttttc cattgagtca tctaccaaag 10621 gagatgtcaa gggttcggtt ctttctcggg aatattcagg aactattgct agtgaggcca 10681 acacttactt gaattccaag agcacacggt cttcagtgaa gctgcagggc acttccaaaa 10741 ttgatgatat ctggaacctt gaagtaaaag aaaattttgc tggagaagcc acactccaac 10801 gcatatattc cctctgggag cacagtacga aaaaccactt acagctagag ggcctctttt 10861 tcaccaacgg agaacataca agcaaagcca ccctggaact c tctccatgg caaatgtcag 10921 ctcttgttca ggtccatgca agtcagccca gttccttcca tgatttccct gaccttggcc 10981 aggaagtggc cctgaatgct aacactaaga accagaagat cagatggaaa aatgaagtcc 11041 ggattcattc tgggtctttc cagagccagg tcgagctttc caatgaccaa gaaaaggcac 11101 accttgacat tgcaggatcc ttagaaggac acctaaggtt cctcaaaaat atcatcctac 11161 cagtctatga caagagctta tgggatttcc taaagctgga tgtaaccacc agcattggta 11221 ggagacagca tcttcgtgtt tcaactgcct ttgtgtacac caaaaacccc aatggctatt 11281 cattctccat ccctgtaaaa gttttggctg ataaattcat tactcctggg ctgaaactaa 11341 atgatctaaa ttcagttctt gtcatgccta cgttccatgt cccatttaca gatcttcagg 11401 ttccatcgtg caaacttgac ttcagagaaa tacaaatcta taagaagctg agaacttcat 11461 catttgccct caacctacca acactccccg aggtaaaatt ccctgaagtt gatgtgttaa 11521 caaaatattc tcaaccagaa gactccttga ttcccttttt tgagataacc gtgcctgaat 11581 ctcagttaac tgtgtcccag ttcacgcttc caaaaagtgt ttcagatggc attgctgctt 11641 tggatctaaa tgcagtagcc aacaagatcg cagactttga gttgcccacc atcatcgtgc 11701 ctgagcagac cattgagatt ccctccatta agttctctgt acctgctgga attgtcattc 11761 cttcctttca agcactgact gcacgctttg aggtagactc tcccgtgtat aatgccactt 11821 ggagtgccag tttgaaaaac aaagcagatt atgttgaaac agtcctggat tccacatgca 11881 gctcaaccgt acagttccta gaatatgaac taaatgtttt gggaacacac aaaatcgaag 11941 atggtacgtt agcctctaag actaaaggaa cacttgcaca ccgtgacttc agtgcagaat 12001 atgaagaaga tggcaaattt gaaggacttc aggaatggga aggaaaagcg cacctcaata 12061 tcaaaagccc agcgttcacc gatctccatc tgcgctacca gaaagacaag aaaggcatct 12121 ccacctcagc agcctcccca gccgtaggca ccgtgggcat ggatatggat gaagatgacg 12181 acttttctaa atggaacttc tactacagcc ctcagtcctc tccagataaa aaactcacca 12241 tattcaaaac tgagttgagg gtccgggaat ctgatgagga aactcagatc aaagttaatt 12301 gggaagaaga ggcagcttct ggcttgctaa cctctctgaa agacaacgtg cccaaggcca 12361 caggggtcct ttatgattat gtcaacaagt accactggga acacacaggg ctcaccctga 12421 gagaagtgtc ttcaaagctg agaagaaatc tgcagaacaa tgctgagtgg gtttatcaag 12481 gggccattag gcaaattgat gatatcgacg tgaggttcca gaaagcagcc agtggcacca 12541 ctgggaccta ccaagagtgg aaggacaagg cccagaatct gtaccaggaa ctgttgactc 12601 aggaaggcca agccagtttc cagggactca aggataacgt gtttgatggc ttggtacgag 12661 ttactcaaaa attccatatg aaagtcaagc atctgattga ctcactcatt gattttctga 12721 acttccccag attccagttt ccggggaaac ctgggatata cactagggag gaactttgca 12781 ctatgttcat aagggaggta gggacggtac tgtcccaggt atattcgaaa gtccataatg
12841 gttcagaaat actgttttcc tatttccaag acctagtgat tacacttcct ttcgagttaa
12901 ggaaacataa actaatagat gtaatctcga tgtataggga actgttgaaa gεa-tttatcaa
12961 aagaagccca agaggtattt aaagccattc agtctctcaa gaccacagag gtgctacgta
13021 atcttcagga ccttttacaa ttcattttcc aactaataga agataacatt aaacagctga
13081 aagagatgaa atttacttat cttattaatt atatccaaga tgagatcaac acaatcttca
13141 atgattatat cccatatgtt tttaaattgt tgaaagaaaa cctatgcctt aatcttcata
13201 agttcaatga atttattcaa aacgagcttc aggaagcttc tcaagagtta cagcagatcc
13261 atcaatacat tatggccctt cgtgaagaat attttgatcc aagtatagtt ggctggacag
13321 tgaaatatta tgaacttgaa gaaaagatag tcagtctgat caagaacctg ttagttgctc
13381 ttaaggactt ccattctgaa tatattgtca gtgcctctaa ctttacttcc caactctcaa
13441 gtcaagttga gcaatttctg cacagaaata ttcaggaata tcttagcatc cttaccgatc
13501 cagatggaaa agggaaagag aagattgcag agctttctgc cactgctcag gsaataatta
13561 aaagccaggc cattgcgacg aagaaaataa tttctgatta ccaccagcag tttagatata
13621 aactgcaaga tttttcagac caactctctg attactatga aaaatttatt gctgaatcca
13681 aaagattgat tgacctgtcc attcaaaact accacacatt tctgatatac atcacggagt
13741 tactgaaaaa gctgcaatca accacagtca tgaaccccta catgaagctt gctccaggag
13801 aacttactat catcctctaa ttttttaaaa gaaatcttca tttattcttc ttttccaatt
13861 gaactttcac atagcacaga aaaaattcaa actgcctata ttgataaaac catacagtga
13921 gccagccttg cagtaggcag tagactataa gcagaagcac atatgaactg gacctgcacc
13981 aaagctggca ccagggctcg gaaggtctct gaactcagaa ggatggcatt ttttgcaagt
14041 taaagaaaat caggatctga gttattttgc taaacttggg ggaggaggaa caaataaatg
14101 gagtctttat tgtgtatcat a
IL1RL2 cDNA sequence fSEO ID NO: 16)
NM_003854 Homo sapiens interleukin 1 receptor-like 2 (IL1RL2), mRNA.
1 cccgcccacg gtggcgggga aatacctagg catggaagtg gcatgacagg gctcgtgtcc 61 ctgtcatatt ttccactctc cacgaggtcc tgcgcgcttc aatcctgcag gcagcccggt 121 ttggggatgt ggtccttgct gctctgcggg ttgtccatcg cccttccact gtctgtcaca 181 gcagatggat gcaaggacat ttttatgaaa aatgagatac tttcagcaag ccagcctttt 241 gcttttaatt gtacattccc tcccataaca tctggggaag tcagtgtaac atggtataaa 301 aattctagca aaatcccagt gtccaaaatc atacagtcta gaattcacca ggacgagact 361 tggattttgt ttctccccat ggaatggggg gactcaggag tctaccaatg tgttataaag 421 ggtagagaca gctgtcatag aatacatgta aacctaactg tttttgaaaa acattggtgt 481 gacacttcca taggtggttt accaaattta tcagatgagt acaagcaaat a acatctt 541 ggaaaagatg atagtctcac atgtcatctg cacttcccga agagttgtgt tttgggtcca 601 ataaagtggt ataaggactg taacgagatt aaaggggagc ggttcactgt tttggaaacc 661 aggcttttgg tgagcaatgt ctcggcagag gacagaggga actacgcgtg tcaagccata 721 ctgacacact cagggaagca gtacgaggtt ttaaatggca tcactgtgag cattacagaa 781 agagctggat atggaggaag tgtccctaaa atcatttatc caaaaaatca ttcaattgaa 841 gtacagcttg gtaccactct gattgtggac tgcaatgtaa cagacaccaa ggataataca goi aatctacgat gctggagagt caataacact ttggtggatg attactatga tgaatccaaa g61 cgaatcagag aaggggtgga aacccatgtc tcttttcggg aacataattt gt acacagta
1021 aacatcacct tcttggaagt gaaaatggaa gattatggcc ttcctttcat gtgccacgct
1081 ggagtgtcca cagcatacat tatattacag ctcccagctc cggattttcg agcttacttg
1141 ataggagggc ttatcgcctt ggtggctgtg gctgtgtctg ttgtgtacat at acaacatt
1201 tttaagatcg acattgttct ttggtatcga agtgccttcc attctacaga gaccatagta
1261 gatgggaagc tgtatgacgc ctatgtctta taccccaagc cccacaagga aagccagagg
1321 catgccgtgg atgccctggt gttgaatatc ctgcccgagg tgttggagag acaatgtgga
1381 tataagttgt ttatattcgg cagagatgaa ttccctggac aagccgtggc caatgtcatc
1441 gatgaaaacg ttaagctgtg caggaggctg attgtcattg tggtccccga atcgctgggc
1501 tttggcctgt tgaagaacct gtcagaagaa caaatcgcgg tctacagtgc cctgatccag
1561 gacgggatga aggttattct cattgagctg gagaaaatcg aggactacac agtcatgcca
1621 gagtcaattc agtacatcaa acagaagcat ggtgccatcc ggtggcatgg ggacttcacg
1681 gagcagtcac agtgtatgaa gaccaagttt tggaagacag tgagatacca catgccgccc
1741 agaaggtgtc ggccgtttcc tccggtccag ctgctgcagc acacaccttg ctaccgcacc
1801 gcaggcccag aactaggctc aagaagaaag aagtgtactc tcacgactgg ctaagacttg
1861 ctggactgac acctatggct ggaagatgac ttgttttgct ccatgtctcc tcattcctac
1921 acctattttc tgctgcagga tgaggctagg gttagcattc taga ILIRLI cDNA sequence 1 fSEO ID NO: 17
NM_016232 Homo sapiens interleukin 1 receptor-like 1 (ILIRLI), transcript variant 1, mRNA 1 aaagagaggc tggctgttgt atttagtaaa gctataaagc tgtaagagaa attggctttc 61 tgagttgtga aactgtgggc agaaagttga ggaagaaaga actcaagtac aacccaatga 121 ggttgagata taggctactc ttcccaactc agtcttgaag agtatcacca actgcctcat 181 gtgtggtgac cttcactgtc gtatgccagt gactcatctg gagtaatctc aacaacgagt 241 taccaatact tgctcttgat tgataaacag aatggggttt tggatcttag caattctcac 301 aattctcatg tattccacag cagcaaagtt tagtaaacaa tcatggggcc tggaaaatga 361 ggctttaatt gtaagatgtc ctagacaagg aaaacctagt tacaccgtgg attggtatta 421 ctcacaaaca aacaaaagta ttcccactca ggaaagaaat cgtgtgtttg cctcaggcca 481 acttctgaag tttctaccag ctgcagttgc tgattctggt atttatacct gtattgtcagj 541 aagtcccaca ttcaatagga ctggatatgc gaatgtcacc atatataaaa aacaatcaga 601 ttgcaatgtt ccagattatt tgatgtattc aacagtatct ggatcagaaa aaaattccaa 661 aatttattgt cctaccattg acctctacaa ctggacagca cctcttgagt ggtttaagaa 721 ttgtcaggct cttcaaggat caaggtacag ggcgcacaag tcatttttgg tcattgataa 781 tgtgatgact gaggacgcag gtgattacac ctgtaaattt atacacaatg aaaatggagσ 841 caattatagt gtgacggcga ccaggtcctt cacggtcaag gatgagcaag gcttttctct 901 gtttccagta atcggagccc ctgcacaaaa tgaaataaag gaagtggaaa ttggaaaaaa 961 cgcaaaccta acttgctctg cttgttttgg aaaaggcact cagttcttgg ctgccgtcct
1021 gtggcagctt aatggaacaa aaattacaga ctttggtgaa ccaagaattc aacaagagga
1081 agggcaaaat caaagtttca gcaatgggct ggcttgtcta gacatggttt taagaatagc
1141 tgacgtgaag gaagaggatt tattgctgca gtacgactgt ctggccctga atttgcatgg
1201 cttgagaagg cacaccgtaa gactaagtag gaaaaatcca attgatcatc atagcatcta
1261 ctgcataatt gcagtatgta gtgtattttt aatgctaatc aatgtcctgg ttatcatcct
1321 aaaaatgttc tggattgagg ccactctgct ctggagagac atagctaaac cttacaagac
1381 taggaatgat ggaaagctct atgatgctta tgttgtctac ccacggaact acaaatccag
1441 tacagatggg gccagtcgtg tagagcactt tgttcaccag attctgcctg atgttcttga
1501 aaataaatgt ggctatacct tatgcattta tgggagagat atgctacctg gagaagatgt
1561 agtcactgca gtggaaacca acatacgaaa gagcaggcgg cacattttca tcctgacccc
1621 tcagatcact cacaataagg agtttgccta cgagcaggag gttgccctgc actgtgccct
1681 catccagaac gacgccaagg tgatacttat tgagatggag gctctgagcg agctggacat
1741 gctgcaggct gaggcgcttc aggactccct ccagcatctt atgaaagtac aggggaccat
1801 caagtggagg gaggaccaca ttgccaataa aaggtccctg aattctaaat tctggaagca
1861 cgtgaggtac caaatgcctg tgccaagcaa aattcccaga aaggcctcta gtttgactcc
1921 cttggctgcc cagaagcaat agtgcctgct gtgatgtgca aaggcatctg agtttgaagc
1981 tttcctgact tctcctagct ggcttatgcc cctgcactga agtgtgagga gcaggaatat
2041 taaagggatt caggcctc
ILIRLI cDNA sequence 2 (SEQ ID NO: 18
NM_003856 Homo sapiens interleukin 1 receptor-like 1 (ILIRLI), transcript variant 2, mRNA 1 gaggagggac ctacaaagac tggaaactat tcttagctcc gtcactgact ccaagttcat 61 cccctctgtc tttcagtttg gttgagatat aggctactct tcccaactca gtcttgaaga 121 gtatcaccaa ctgcctcatg tgtggtgacc ttcactgtcg tatgccagtg actcatctgg 181 agtaatctca acaacgagtt accaatactt gctcttgatt gataaacaga atggggtttt 241 ggatcttagc aattctcaca attctcatgt attccacagc agcaaagttt agtaaacaat 301 catggggcct ggaaaatgag gctttaattg taagatgtcc tagacaagga aaacctagtt 361 acaccgtgga ttggtattac tcacaaacaa acaaaagtat tcccactcag gaaagaaatc 421 gtgtgtttgc ctcaggccaa cttctgaagt ttctaccagc tgcagttgct gattctggta 481 tttatacctg tattgtcaga agtcccacat tcaataggac tggatatgcg aatgtcacca 541 tatataaaaa acaatcagat tgcaatgttc cagattattt gatgtattca acagtatctg 601 gatcagaaaa aaattccaaa atttattgtc ctaccattga cctctacaac tggacagcac 661 ctcttgagtg gtttaagaat tgtcaggctc ttcaaggatc aaggtacagg gcgcacaagt 721 catttttggt cattgataat gtgatgactg aggacgcagg tgattacacc tgtaaattta 781 tacacaatga aaatggagcc aattatagtg tgacggcgac caggtccttc acggtcaagg 841 atgagcaagg cttttctctg tttccagtaa tcggagcccc tgcacaaaat gaaataaagg 901 aagtggaaat tggaaaaaac gcaaacctaa cttgctctgc ttgttttgga aaaggcactc 961 agttcttggc tgccgtcctg tggcagctta atggaacaaa aattacagac tttggtgaac 1021 caagaattca acaagaggaa gggcaaaatc aaagtttcag caatgggctg gcttgtctag 1081 acatggtttt aagaatagct gacgtgaagg aagaggattt attgctgcag tacgactgtc 1141 tggccctgaa tttgcatggc ttgagaaggc acaccgtaag actaagtagg aaaaatccaa 1201 gtaaggagtg tttctgagac tttgatcacc tgaactttct ctagcaagtg taagcagaat 1261 ggagtgtggt tccaagagat ccatcaagac aatgggaatg gcctgtgcca taaaatgtgc 1321 ttctcttctt cgggatgttg tttgctgtct gatctttgta gactgttcct gtttgctggg 1381 agcttctctg ctgcttaaat tgttcgtcct cccccactcc ctcctatcgt tggtttgtct 1441 agaacactca gctgcttctt tggtcatcct tgttttctaa ctttatgaac tccctctgtg 1501 tcactgtatg tgaaaggaaa tgcaccaaca accgtaaact gaacgtgttc ttttgtgctc 1561 ttttataact tgcattacat gttgtaagca tggtccgttc tatacctttt tctggtcata 1621 atgaacactc attttgttag cgagggtggt aaagtgaaca aaaaggggaa gtatcaaact 1681 actgccattt cagtgagaaa atcctaggtg ctactttata ataagacatt tgttaggcca 1741 ttcttgcatt gatataaaga aatacctgag actgggtgat ttatatgaaa agaggtttaa 1801 ttggctcaca gttctgcagg ctgtatggga agcatggcgg catctgcttc tggggacacc 1861 tcaggagctt tactcatggc agaaggcaaa gcaaaggcag gcacttcaca cagtaaaagc 1921 aggagcgaga gagaggtgcc acactgaaac agccagatct catgagaagt cactcactat 1981 tgcaaggaca gcatcaaaga gatggtgcta aaccattcat gatgaactca cccccatgat 2041 ccaatcacct cccaccaggc tccacctcga atactgggga ttaccattca gcatgagatt 2101 tgggcaggaa cacagaccca aaccatacca cacacattat cattgttaaa ctttgtaaag 2161 tatttaaggt acatggaaca cacgggaagt ctggtagctc agcccatttc tttattgcat 2221 ctgttattca ccatgtaatt caggtaccac gtattccagg gagcctttct tggccctcag 2281 tttgcagtat acacactttc caagtactct tgtagcatcc tgtttgtatc atagcactgg 2341 tcacattgcc ttacctaaat ctgtttgaca gtctgctcaa cacgactgca agctccatga 2401 gggcagggac atcatctctt ccatctttgg gtccttagtg caatacctgg cagctagcca 2461 gtgctcagct aaatatttgt tgactgaata aatgaatgca caaccaaaaa aaaaaaaaaa 2521 aaaaaaaaaa aaaaaaaaaa aa
ILIRLI cDNA sequence 3 (SEQ IDNO: 19)
NM_173459 Homo sapiens interleukin 1 receptor-like 1 (ILIRLI), transcript variant 3, mRNA 1 gaggagggac ctacaaagac tggaaactat tcttagctcc gtcactgact ccaagttcat 61 cccctctgtc tttcagtttg gttgagatat aggctactct tcccaactca gtcttgaaga 121 gtatcaccaa ctgcctcatg tgtggtgacc ttcactgtcg tatgccagtg actcatctgg 181 agtaatctca acaacgagtt accaatactt gctcttgatt gataaacaga atggggtttt 241 ggatcttagc aattctcaca attctcatgt attccacagc agcaaagttt agtaaacaat 301 catggggcct ggaaaatgag gctttaattg taagatgtcc tagacaagga aaacctagtt 361 acaccgtgga ttggtattac tcacaaacaa acaaaagtat tcccactcag gaaagaaatc 421 gtgtgtttgc ctcaggccaa cttctgaagt ttctaccagc tgcagttgct gattctggta 481 tttatacctg tattgtcaga agtcccacat tcaataggac tggatatgcg aatgtcacca 541 tatataaaaa acaatcagat tgcaatgttc cagattattt gatgtattca acagtatctg 601 gatcagaaaa aaattccaaa atttattgtc ctaccattga cctctacaac tggacagcac 661 ctcttgagtg gtttaagaat tgtcaggctc ttcaaggatc aaggtacagg gcgcacaagt 721 catttttggt cattgataat gtgatgactg aggacgcagg tgattacacc tgtaaattta 781 tacacaatga aaatggagcc aattatagtg tgacggcgac caggtccttc acggtcaagg 841 tttggtgtca gagtttctgc aaattaaaaa agagcttaat ctttagtaat actcattgga 901 ttcaaagtct aatgagaggc tttgtgatgg tatactatgg tgtacataaa tgttgtcgag 961 tggtttttaa tctttgtttg caatactttc aacatcatca atggccttga atgagcaagg
1021 cttttctctg tttccagtaa tcggagcccc tgcacaaaat gaaataaagg aagtggaaat
1081 tggaaaaaac gcaaacctaa cttgctctgc ttgttttgga aaaggcactc agttcttggc
1141 tgccgtcctg tggcagctta atggaacaaa aattacagac tttggtgaac caagaattca
1201 acaagaggaa gggcaaaatc aaagtttcag caatgggctg gcttgtctag acatggtttt
1261 aagaatagct gacgtgaagg aagaggattt attgctgcag tacgactgtc tggccctgaa
1321 tttgcatggc ttgagaaggc acaccgtaag actaagtagg aaaaatccaa gtaaggagtg
1381 tttctgagac tttgatcacc tgaactttct ctagcaagtg taagcagaat ggagtgtggt
1441 tccaagagat ccatcaagac aatgggaatg gcctgtgcca taaaatgtgc ttctcttctt
1501 cgggatgttg tttgctgtct gatctttgta gactgttcct gtttgctggg agcttctctg
1561 ctgcttaaat tgttcgtcct cccccactcc ctcctatcgt tggtttgtct agaacactca
1621 gctgcttctt tggtcatcct tgttttctaa ctttatgaac tccctctgtg tcactgtatg
1681 tgaaaggaaa tgcaccaaca accgtaaact gaacgtgttc ttttgtgctc ttttataact
1741 tgcattacat gttgtaagca tggtccgttc tatacctttt tctggtcata atgaacactc
1801 attttgttag cgagggtggt aaagtgaaca aaaaggggaa gtatcaaact actgccattt 1861 cagtgagaaa atcctaggtg ctactttata ataagacatt tgttaggcca ttcttgcatt
1921 gatataaaga aatacctgag actgggtgat ttatatgaaa agaggtttaa ttggctcaca
1981 gttctgcagg ctgtatggga agcatggcgg catctgcttc tggggacacc tcaggagctt
2041 tactcatggc agaaggcaaa gcaaaggcag gcacttcaca cagtaaaagc aggagcgaga
2101 gagaggtgcc acactgaaac agccagatct catgagaagt cactcactat tgcaaggaca
2161 gcatcaaaga gatggtgcta aaccattcat gatgaactca cccccatgat ccaatcacct
2221 cccaccaggc tccacctcga atactgggga ttaccattca gcatgagatt tgggcaggaa
2281 cacagaccca aaccatacca cacacattat cattgttaaa ctttgtaaag tatttaaggt
2341 acatggaaca cacgggaagt ctggtagctc agcccatttc tttattgcat ctgttattca
2401 ccatgtaatt caggtaccac gtattccagg gagcctttct tggccctcag tttgcagtat
2461 acacactttc caagtactct tgtagcatcc tgtttgtatc atagcactgg tcacattgcc
2521 ttacctaaat ctgtttgaca gtctgctcaa cacgactgca agctccatga gggcagggac
2581 atcatctctt ccatctttgg gtccttagtg caatacctgg cagctagcca gtgctcagct
2641 aaatatttgt tgactgaata aatgaatgca caaccaaaaa aaaaaaaaaa aaaaaaaaaa
2701 aaaaaaaaaa aa
WASPIP cDNA sequence 1 (SEQ ID NO: 20
NM_003387 Homo sapiens Wiskott-Aldrich syndrome protein interacting protein (WASPIP), mRNA
1 tagaagacag caggggaact cgagaagttg gttgttttca gcagattaaa acaatacaga 61 tttatcagca agactgttga acgcataact gcccaagatg cctgtccctc cccctccagc 121 acccccgccg cccccgacgt ttgcactggc caatacagag aagcctacct tgaataagac 181 agagcaggct gggagaaatg ctctcctttc tgatatcagc aaagggaaga aactaaagaa 241 gacggtcacc aatgacagaa gtgcaccaat actggacaaa cctaaaggag ctggtgctgg 301 aggcggtggt ggtggctttg gtggaggcgg cggatttggc ggaggaggtg gtggcggagg 361 cggtggaagt tttggagggg gcggacctcc aggtctggga ggattgttcc aggctggaat 421 gccgaagctg agatccacgg ccaacaggga taatgattct ggaggaagcc gaccaccatt 481 gttgccaccg ggaggaagat ccacatctgc gaaacccttt tcacccccaa gtggcccagg 541 gaggtttcct gtgccttctc caggccacag aagtggtccc ccagagcctc agaggaaccg 601 aatgccgccc ccaaggcccg acgtgggctc aaagcctgat agcattcctc ctccagtacc 661 tagtactcca agacccattc aatcaagtcc gcacaaccgg gggtccccac cagtgcccgg 721 aggccccagg cagcccagcc ccgggcccac tcctccccct ttccctggaa accgcggcac 781 tgctttggga ggaggctcaa tacgtcagtc ccccttgagc tcctcctcgc ccttctccaa 841 ccggcctccc ctgccgccta cccccagcag ggccttggat gacaaacccc ctccaccacc 901 tcctccagtg ggcaacaggc cctccatcca cagggaagcg gttccccctc ctcctcctca 961 gaacaacaag cctccagtgc cttccactcc gcggccttcg gcctcctcac aggccccacc
1021 tccgccgcca cctcccagca ggcccgggcc gcctcctctg cctccaagtt ccagcggcaa
1081 tgacgaaacc ccaagactcc cacagcggaa tctgtccctc agttcgtcca cgcccccgtt
1141 accttcgcca ggacgttcag gtcctcttcc tcccccgccc agtgagagac ccccacctcc
1201 agtgagggac ccgccaggcc gatcaggccc cctcccacca cctcctccag taagcagaaa
1261 cggcagcaca tctcgggccc tgcctgctac ccctcagttg ccatccagga gtggagtaga
1321 cagtcccagg agtggaccca ggcctcccct tcctcctgat aggcccagtg ctggggcacc
1381 tcccccacct ccaccatcaa catctattag aaatggcttc caagactctc catgtgaaga
1441 tgagtgggaa agcagattct acttccatcc gatttccgat ttgccacctc cagagccata
1501 tgtacaaacg accaaaagtt atcccagcaa actggcaaga aacgaaagcc ggagtggatc
1561 caaccgaaga gaaaggggtg ctccaccact ccctcccatc ccgaggtgat ctttgcctgc
1621 tcttctctac ccaagctcaa gagctgcttc tgttgctatc taagaactgc ataccctcct
1681 ccctgcttct tcccttgtgc ctcatgtatg ggcaggagga aaggtgggag ggggagtggg
1741 aatatgcgtg tgtgggtggg aatcggtaag aaatgcacct agcttttcat attgtgttta
1801 ttctccaggc tattgcttgc ttcagctgca gcctgcctgt gctggctgct ggggtcgata
1861 ggcttttgtc gtaataggca gagatgactt gcatcccagc tttccaccaa ccaaattcaa
1921 acattcactg cttatttgtt acagactgta attattaaag tccctgagag ctgttttctc
1981 ccgttccttt ttcgcatgct tggcctcctc tctgtttcta tgaaccacag accacctaag
2041 caagctgctg agtaagggct cactggaaac ttgcagtcac aggatgtcca atctttggca
2101 gtccgagctt ggctctagga cagagctgtc caatagaaat ataatgtgag ccccatatac
2161 aatttttaca tttctaatat attttaaaca agtgaagtta atatgcatcc aaaatatttc
2221 aacctgtaat caacataaaa ttttaatgag atattttata ttattttttg gtactgaatc
2281 ttcaaaatcc agagtgtatt ttacacttac cgcacatctc cattcagact agtcacattt
2341 ttaagtgctc agtagccaca tgtggctggt ggctactgga ttagacagca cgagtctgga
2401 agatggaagc tagtgcagaa acctcttgtt taaaaaacaa aaaaggcaag atgggcttga
2461 gcgattcaag aggcaactaa aaataaaatt aggacccagc accttgtttg acacacagtt 2521 tgaccttcga ttttcctccc ttaacttccc tcttccctta atatctgtat acaagtgttg
2581 cttcaaagta ccaaggtcag aaattgattc agtacggttt actaaagtca tgtggaataa
2641 agccattgga aacaaatgga aagcctgtcg ggacttctgg gctcagaacc agctggctca
2701 cgcactccac ttgtcagctg gacttctgcc ttgtgaaatg gaagcagcct ttgttccttt
2761 ctggctgagc aagctcctga ggctgggaga gactaggaag gcttggtagg aggggaaaaa
2821 agtcaggaaa agatatcaaa tcagaaacat ggaagaagaa gggaaccgat ttgagttggt
2881 gggcaaaact ctaaaaatct aaatctgatg cttatgtaag ggttgagcga attagggaga
2941 ttgctagtgg aaattggagg gaatttgttt tgcatcattt gtctaggatc tatgcaaata
3001 tagctccact aaaggaccat agggaagagc cagccttgcc ttttcttata tgattttgtt
3061 tacaaaattt tactgggact tttaaatcta gctatagagt tgggaaaaaa tatttccact
3121 tagatatttt acatggtttt gtttaaaatt accattactt gttttttaaa aacacatgac
3181 cacatatgta tatgtatatc tacctaaaca ttgtatcatg gtttcagtat gttattcatg
3241 tattactggg agatgctacc aagaaaccaa cccaaagaaa attctgaaaa atacatttct
3301 atttatagaa taaatgtttc atttatataa aagcaaaaga acttagagtt ctaataaatg
3361 ggatgtctaa taaattatga agttactgat ttgaatatat tatattttta taacttcctt
3421 gccaaagtcc tgatttagta cattagagaa cctgtgtttc ctctctcctc taccattcat
3481 ctctcttcca tacagtcatt tgggcttttt actcaaagag aatcaagaaa taataaggta
3541 taacaagctt ggcaaagtgt tggcttttta aaaaaaaatt tttttaatct ctagcagttt
3601 ggtaatttag cagcatcatt tatttgggat tcttttatct gatttcaaca gtgaaaaaca
3661 tccctatgat aaagcctaat gacccatttc acaaaagatg gaatttgccc ttcctagaaa
3721 atatgacgga gaaaagtctg actcagagaa agtgagtctg aattttataa ggggtagtaa
3781 gaattggaca attcctttgc atatctgaac ttggcaggta ccgttctaaa tctgaaacag
3841 ggtgatagct caaagttgcc attcatccag aatagattgt tttagaatgt agtgtttaag
3901 tgactgtttc attaatacac ctacaccctt tctttgaaag tttgcaacct aattgcatct
3961 aaaactatga ataagttctg tggtaaaatc ttaaactatg gaaaattaca aaaatgaatt
4021 tttcttccct gaaatcagag cttacatgtg tgttttttta taacattttc agataaatgt
4081 attcaacatg taatacagta ttttaacatt cacctcttat tttatattga aatgtattac
4141 agtattaaaa ctcagtgttc agtatttatt tcactatgca ttttatttag taaaagccag
4201 gagaaatgtt taatccaatg gtgccttact ttgtgattta aaagaaatca actttttttt
4261 atgtctaagt agtagattat ttgcatattt gtaaaaactg ttaggtcttt atattttaaa
4321 gtgtaatacc agttttgtta ttttagtagc agaaatggga tgattgttaa agttccccaa
4381 aaatgttggc atgaaattaa tttttccctc cttatagtca aggaccgtag aggaagaaaa
4441 actttttttt cataccatgc actatgtaaa cagacacatt ttgctatctg tgtcatcagg
4501 atagtgtaag tggtagggta gagactaccc tagacatctg catctttgta agttagccag
4561 acaataaaga aaagcagaat gaaaaaaaaa aaaaaaaaaa aaaaa
ADAMTS2 cDNA sequence 1 (SEQ ID NO: 21)
NM_014244 Homo sapiens a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 (ADAMTS2), transcript variant 1, mRNA 1 atggatccgc cggcgggagc cgctcgccgc ctgctctgcc ccgcgctgct gctgctgctg 61 ctgctgctgc cgccgccgct cctgccgccg ccgccgccgc ccgcgaacgc caggctcgcc 121 gccgccgccg accccccagg cgggcccctg gggcacggag cggagcgcat cctggcggtg 181 cccgtgcgca ctgacgccca gggccgcttg gtgtcccacg tggtgtcggc agctacgtcc 241 agagcagggg tacgagcccg cagggccgcc ccggtccgga ccccgagctt ccccggaggc 301 aacgaggagg agcctggcag tcacctcttc tacaatgtca cggtctttgg ccgagacctg 361 cacctgcggc tgcggcccaa cgcccgcctc gtggcgcccg gggccactat ggagtggcag 421 ggcgagaagg gcaccacccg cgtggagccc ctgctcggga gctgtctcta cgtcggagac 481 gtggccggcc tagccgaagc ctcctctgtg gcgctcagca actgcgatgg gctggctggt 541 ctgatccgga tggaggagga ggagttcttc atcgaaccct tggagaaggg gctggcggcg 601 caggaggctg agcaaggccg tgtgcatgtg gtgtatcgcc ggccacccac gtcccctcct 661 ctcggggggc cacaggccct ggacacaggg gcctccctgg acagcctgga cagcctcagc 721 cgcgccctgg gcgtcctaga ggagcacgcc aacagctcga ggcggagggc acgcaggcat 781 gctgcagacg atgactacaa catcgaggtc ctgctgggcg tggatgactc tgtggtgcag 841 ttccacggga aggagcacgt acagaagtac ctgctgacac tcatgaacat tgtcaatgaa 901 atctaccatg acgagtcctt gggtgcccac atcaacgtgg tcctggtgcg gatcatcctc 961 ctgagctatg gaaagtccat gagcctcatc gagatcggga acccctctca gagcctggag
1021 aatgtctgcc gctgggccta cctccagcag aagccagaca cgggccacga tgaataccac
1081 gatcacgcca tcttcctcac acggcaggac tttgggcctt ccggcatgca aggctatgct
1141 cctgtcaccg gcatgtgcca tccggtccgc agctgcaccc tgaaccatga ggacggcttc
1201 tcctcagcgt ttgtggtggc ccatgagact ggccacgtgc tgggcatgga gcacgacggg
1261 cagggcaacc gctgtggcga cgaggtgcgg ctgggcagca tcatggcgcc cctggtgcag 1321 gccgccttcc accgcttcca ctggtcccgc tgcagccagc aggagctgag ccgctacctg
1381 cactcctatg actgcctgct ggatgacccc ttcgcccacg actggccggc gctgccccag
1441 ctcccgggac tgcactactc catgaacgag caatgccgct ttgacttcgg cctgggctac
1501 atgatgtgca cggcgttccg gacctttgac ccctgcaagc agctgtggtg cagccatcct
1561 gacaacccct acttttgcaa gaccaagaag gggcccccct tggacgggac tatgtgtgca
1621 cctggcaagc attgttttaa aggacactgc atctggctga cacctgacat cctcaaacgg
1681 gacggcagct ggggcgcttg gagtccgttt ggctcctgct cacgtacctg tggcacgggc
1741 gtgaagttca ggacccgcca gtgtgacaac ccacacccgg ccaacggggg ccgcacctgc
1801 tcgggccttg cctacgactt ccagctctgc agccgccagg actgccccga ctccctggct
1861 gacttccgcg aggagcagtg ccgccagtgg gacctgtact tcgagcacgg cgacgcccag
1921 caccactggc tgccccacga gcaccgggat gccaaggaga gatgccacct gtactgcgag ig81 tccagggaga ccggggaggt ggtgtccatg aagcgcatgg tgcatgatgg gacgcgctgc
2041 tcctacaagg acgccttcag cctctgtgtg cgcggggact gcaggaaggt gggctgtgac
2101 ggtgtgatcg gctccagcaa gcaggaagac aagtgtggcg tgtgcggagg ggacaacagc
2161 cactgcaaag tggtcaaggg cacgttcaca cggtcaccca agaagcatgg ttacatcaag
2221 atgtttgaga tccctgcagg agccagacac ctgctcattc aggaggtaga cgccaccagc
2281 caccatctgg ccgtcaagaa cctggagaca ggcaagttca tcttaaatga agagaatgac
2341 gtggatgcca gttccaaaac cttcattgcc atgggcgtgg agtgggagta cagagacgag
2401 gacggccggg agacgctgca gaccatgggc cccctccacg gcaccatcac cgttctggtc
2461 atcccggtgg gagacacccg ggtctcactg acgtacaaat acatgatcca tgaggactca
2521 ctgaatgtcg atgacaacaa cgtcctggaa gaggactctg tggtctacga gtgggccetg
2581 aagaagtggt ctccgtgctc caagccctgt ggcggagggt cccagttcac caagtatggc
2641 tgccgccgga ggctggacca caagatggta caccgtggct tctgtgccgc cctctcgaag
2701 cccaaagcca tccgcagagc gtgcaaccca caggaatgct cccagccagt gtgggtcaca
2761 ggcgaatggg agccatgtag ccagacctgt gggcggacag gcatgcaggt gcgctccgtg
2821 cgctgcattc agccgctaca cgacaacacc acccgctccg tgcacgccaa gcactgcaat
2881 gacgcccggc ccgagagccg ccgggcctgc agccgcgagc tctgccctgg tcgttggcga
2941 gccgggccct ggtcccagtg ctcagtaacc tgtggcaacg gcacccagga gcggccagtg
3001 ccctgccgca ccgcggacga cagcttcggc atctgccagg aggagcgtcc tgagacagcg
3061 aggacctgca ggcttggccc ctgtccccga aacatctcag atccctccaa gaagagctac
3121 gtagttcagt ggctgtcccg cccggacccc gactcgccca tccggaagat ctcgtcaaag
3181 ggccactgcc aaggcgacaa gtcaatattc tgtaggatgg aagtcttgtc ccgctattgc
3241 tccatcccag gctacaacaa gctgtcctgc aagtcctgta acctgtacaa caacctcacc
3301 aacgtggagg gcaggataga gccaccgcct gggaagcaca acgacattga cgtgttcatg
3361 cctaccctcc cagtgcccac tgtagccatg gaggtgcggc catcaccaag cacccccctg
3421 gaggtccctc tcaatgcctc cagcaccaat gccacagagg atcacccaga aaccaatgcc
3481 gtagatgaac cctacaaaat ccatggcctg gaagatgaag tccagccacc caacctaatc
3541 cctcgacgac cgagccccta tgaaaagacc agaaaccaaa gaatccaaga gctcattgat
3601 gagatgcgga agaaagagat gctcggaaag ttctaa
ADAMTS2 cDNA sequence 2 fSEO ID NO: 22)
NM_021599 Homo sapiens a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 (ADAMTS2), transcript variant 2, mRNA
1 atggatccgc cggcgggagc cgctcgccgc ctgctctgcc ccgcgctgct gctgctgctg 61 ctgctgctgc cgccgccgct cctgccgccg ccgccgccgc ccgcgaacgc caggctcgcc 121 gccgccgccg accccccagg cgggcccctg gggcacggag cggagcgcat cctggcggtg 181 cccgtgcgca ctgacgccca gggccgcttg gtgtcccacg tggtgtcggc agctacgtcc 241 agagcagggg tacgagcccg cagggccgcc ccggtccgga ccccgagctt ccccggaggc 301 aacgaggagg agcctggcag tcacctcttc tacaatgtca cggtctttgg ccgagacctg 361 cacctgcggc tgcggcccaa cgcccgcctc gtggcgcccg gggccactat ggagtggcag 421 ggcgagaagg gcaccacccg cgtggagccc ctgctcggga gctgtctcta cgtcggagac 481 gtggccggcc tagccgaagc ctcctctgtg gcgctcagca actgcgatgg gctggctggt 541 ctgatccgga tggaggagga ggagttcttc atcgaaccct tggagaaggg gctggcggcg 601 caggaggctg agcaaggccg tgtgcatgtg gtgtatcgcc ggccacccac gtcccctcct 661 ctcggggggc cacaggccct ggacacaggg gcctccctgg acagcctgga cagcctcagc 721 cgcgccctgg gcgtcctaga ggagcacgcc aacagctcga ggcggagggc acgcaggcat 781 gctgcagacg atgactacaa catcgaggtc ctgctgggcg tggatgactc tgtggtgcag 841 ttccacggga aggagcacgt acagaagtac ctgctgacac tcatgaacat tgtcaatgaa 901 atctaccatg acgagtcctt gggtgcccac atcaacgtgg tcctggtgcg gatcatcctc 961 ctgagctatg gaaagtccat gagcctcatc gagatcggga acccctctca gagcctggag
1021 aatgtctgcc gctgggccta cctccagcag aagccagaca cgggccacga tgaataccac 1081 gatcacgcca tcttcctcac acggcaggac tttgggcctt ccggcatgca aggctatgct L141 cctgtcaccg gcatgtgcca tccggtccgc agctgcaccc tgaaccatga ggacggcttc L201 tcctcagcgt ttgtggtggc ccatgagact ggccacgtgc tgggcatgga gcacgacggg 1261 cagggcaacc gctgtggcga cgaggtgcgg ctgggcagca tcatggcgcc cctggtgcag 1321 gccgccttcc accgcttcca ctggtcccgc tgcagccagc aggagctgag ccgctacctg 1381 cactcctatg actgcctgct ggatgacccc ttcgcccacg actggccggc gc gccccag 1441 ctcccgggac tgcactactc catgaacgag caatgccgct ttgacttcgg cctgggctac 1501 atgatgtgca cggcgttccg gacctttgac ccctgcaagc agctgtggtg cagccatcct 1561 gacaacccct acttttgcaa gaccaagaag gggcccccct tggacgggac tatgtgtgca 1621 cctggcaagt tcaggccggg cgcggtggct catgcctgtt atcccagcac tttgggaggc 1681 caaggtaggt ggatcgcctg
BVES cDNA sequence 1 (SEQ ID NO: 23) fM_007073 Homo sapiens blood vessel epicardial substance (BVES), transcript variant A, mRNA
1 tcaggcagcc ccagcgtccc cgggccctcg gccccaccga gtgccggctc ccgcgctctg 61 cggcggcaag ccccttggaa ttttcaaaat gaattataca gagtccagcc cattgagaga 121 atcaactgcc ataggtttta cacctgagtt agaaagtatc atacctgtgc cttccaataa 181 gaccacttgt gaaaactgga gagagataca tcatctggtt tttcatgtag caaatatttg 241 ttttgcagtt gggttggtta ttccaactac tcttcacctt catatgatat ttcttagggg 301 aatgttaact ctaggatgta ccctttatat cgtctgggcc actctctacc gatgtgcctt 361 ggatataatg atctggaact ctgtgttctt gggtgtcaac attttgcatc tgtcgtatct 421 tttatacaag aagagaccgg taaagattga aaaggaactc agtggcatgt accggcgatt 481 gtttgaacca ctccgtgtgc ctccagattt gttcagaaga ctaactggac agttttgcat 541 gatccaaacc ttgaaaaagg gccaaactta tgctgcagag gataaaacct cagttgatga 601 ccgtctgagt attctcttga agggaaaaat gaaggtctcc tatcgaggac attttctgca 661 taacatttac ccctgtgcct ttatagattc tcctgaattt agatcaactc agstgcacaa 721 aggtgaaaaa ttccaggtca ccattattgc agatgataac tgcagatttt tatgctggtc 781 aagagaaaga ttaacatact ttctggaatc agaacctttc ttgtatgaaa tctttaggta 841 tcttattgga aaagacatca caaataagct ctactcattg aatgatccca ccttaaatga 901 taaaaaagcc aaaaagctgg aacatcagct cagcctctgc acacagatct ccatgttgga 961 aatgaggaac agtatagcca gctccagtga cagtgacgac ggcttgcacc agtttcttcg
1021 gggtacctcc agcatgtcct ctcttcatgt gtcatcccca caccagcgag cctctgccaa
1081 gatgaaaccg atagaagaag gagcagaaga tgatgatgac gtttttgaac cggcatctcc
1141 aaatacattg aaagtccatc agctgccttg atcagagaga gaattcaggt taccaagacg
1201 gaaggtgtct tgaagagatc ctgaaaaata ccagcacttt ttcatggctt ttaggttatt
1261 ctgctttagt gcatccagac tggtggagtc ggagggagga agtgaggaag ggtcaaggat
1321 ggaagagttc tttcacttac cctttttatt agtcagcttt taaagtaatt gttttactga
1381 gccttctgac tatgccttgt tctcttttga gatatatatt ttcacagtct tttctagata
1441 tattattgtt ttaacttaac aaatcttagc aatctctcaa tgccttttca cttatttttt
1501 tccaagttat gattcttttt cctcacagtc ttttttgttc catagcaatg aggttgtcca
1561 tttgataatt ttaacaaaca atgtaagttt aaaattgagg ctaaggtaac atgaaaaagc
1621 agggaatctc aaactttat
BVES cDNA sequence 2 (SEQ ID NO: 24)
NM_147147 Homo sapiens blood vessel epicardial substance (BVES), transcript variant B, mRNA
1 agagcgccga tggctgggga cccgaggtcc gcgccaccca cccgcaacct ccttccccga 61 gcctttggga acgggttgtt ggccagacaa gtcccagaaa ctgcctgctt tgaagcatga 121 ataagtgcga aaagactctt agcaatgaat tttcaaaatg aattatacag agtccagccc 181 attgagagaa tcaactgcca taggttttac acctgagtta gaaagtatca tacctgtgcc 241 ttccaataag accacttgtg aaaactggag agagatacat catctggttt ttcatgtagc 301 aaatatttgt tttgcagttg ggttggttat tccaactact cttcaccttc atatgatatt 361 tcttagggga atgttaactc taggatgtac cctttatatc gtctgggcca ctctctaccg 421 atgtgccttg gatataatga tctggaactc tgtgttcttg ggtgtcaaca ttttgcatct 481 gtcgtatctt ttatacaaga agagaccggt aaagattgaa aaggaactca gtggcatgta 541 ccggcgattg tttgaaccac tccgtgtgcc tccagatttg ttcagaagac taactggaca 601 gttttgcatg atccaaacct tgaaaaaggg ccaaacttat gctgcagagg ataaaacctc 661 agttgatgac cgtctgagta ttctcttgaa gggaaaaatg aaggtctcct atcgaggaca 721 ttttctgcat aacatttacc cctgtgcctt tatagattct cctgaattta gatcaactca 781 gatgcacaaa ggtgaaaaat tccaggtcac cattattgca gatgataact gcagattttt 841 atgctggtca agagaaagat taacatactt tctggaatca gaacctttct tgtatgaaat 901 ctttaggtat cttattggaa aagacatcac aaataagctc tactcattga atgatcccac 961 cttaaatgat aaaaaagcca aaaagctgga acatcagctc agcctctgca cacagatctc
1021 catgttggaa atgaggaaca gtatagccag ctccagtgac agtgacgacg gcttgcacca
1081 gtttcttcgg ggtacctcca gcatgtcctc tcttcatgtg tcatccccac accagcgagc
1141 ctctgccaag atgaaaccga tagaagaagg agcagaagat gatgatgacg tttttgaacc
1201 ggcatctcca aatacattga aagtccatca gctgccttga tcagagagag aattcaggtt
1261 accaagacgg aaggtgtctt gaagagatcc tgaaaaatac cagcactttt tcatggcttt
1321 taggttattc tgctttagtg catccagact ggtggagtcg gagggaggaa gtgaggaagg
1381 gtcaaggatg gaagagttct ttcacttacc ctttttatta gtcagctttt aaagtaattg
1441 ttttactgag ccttctgact atgccttgtt ctcttttgag atatatattt tcacagtcaa
1501 aaaaaaaaaa aaaa
TM7SF3 cDNA sequence 2 (SEQ ID NO: 25)
NM_016551 Homo sapiens transmembrane 7 superfamily member 3 (TM7SF3), mRNA
1 ccagccctgg cgtgggccca gcccggccca ggcagcaatg gggttcctgc agctgctggt 61 cgtagcggtg ctggcatccg aacaccgggt ggctggtgca gccgaggtct tcgggaattc 121 cagcgagggt cttattgaat tttctgtggg gaaatttaga tacttcgagc tcaataggcc 181 ctttccagag gaagctattt tgcatgatat ttcaagcaat gtgacttttc ttattttcca 241 aatacactca cagtatcaga atacaactgt ttccttttct ccgactctcc tttccaattc 301 ctcggaaaca ggcactgcca gtggactggt tttcatcctt agaccagagc agagtacatg 361 cacttggtac ttggggactt caggcataca gcctgtccag aatatggcta tcctactctc 421 ctactcagaa agagatcctg tccctggagg ctgtaatttg gagttcgatt tagatattga 481 tcccaacatt tacttggagt ataatttctt tgaaacgact atcaagtttg ccccagcaaa 541 cctaggctat gcgagaggcg tagatccccc accatgtgac gctgggacag accaggactc 601 caggtggagg ttgcagtatg atgtctatca gtattttctg cctgagaatg acctcactga 661 ggagatgttg ctgaagcatc tgcagaggat ggtcagtgtg ccccaggtga aggccagtgc 721 tctcaaggtg gttaccctaa cagctaatga taagacaagt gtttccttct cctccctccc 781 gggacaaggt gtcatataca atgtcattgt ttgggacccg tttctaaata catctgctgc 841 ctacattcct gctcacacat acgcttgcag ctttgaggca ggagagggta gttgtgcttc 901 cctaggaaga gtgtcttcca aagtgttctt cactcttttt gccctgcttg gtttcttcat 961 ttgtttcttt ggacacagat tctggaaaac agaattattc ttcataggct ttatcatcat
1021 gggattcttc ttttatatac tgattacaag actgacacct atcaagtatg atgtgaatct
1081 gattctgaca gctgtcactg gaagcgtcgg tggaatgttc ttggtagctg tgtggtggcg
1141 atttggaatc ctctcgatct gcatgctctg tgttggacta gtgctggggt tcctcatctc
1201 gtcagtgact ttctttactc cactgggaaa cctaaagatt tttcatgatg atggtgtatt
1261 ctgggtcact ttctcttgca tagctatcct cattccagta gttttcatgg gctgcctaag
1321 aatactgaac atactgactt gtggagtcat tggctcctat tcggtggttt tagccattga
1381 cagttactgg tccacaagcc tttcctacat cactttgaac gtactcaaga gagcgctcaa
1441 caaggatttc cacagagctt tcacaaatgt gccttttcaa actaatgact tcattatcct
1501 ggcagtatgg ggcatgctgg ctgtaagtgg aattacgtta cagattcgaa gagagagagg
1561 acgaccgttc ttccctcccc acccatacaa gttatggaag caagagagag agcgccgagt
1621 gacaaacatt ctggacccta gctaccacat tcctccattg agagagaggc tctatggccg
1681 attaacccag attaaagggc tcttccagaa ggagcagcca gctggagaga gaacgccttt
1741 gcttctgtag atgcccaggg gcttggtcag tgtgcctcag ctttggagtt catgcctgga
1801 gtggttcaac agtctctggt gcaagtctaa taagagatca ggcatatata tctgttcttt
1861 gcataatatt atggtgccct tattgatata tggtaagggt gtactagggg attaggatga
1921 ttgtaagaga atgagaaaga tgaccaaaag gttggtggta gggaggcttt ttcttatttc
1981 caaatacttg agaaattacc ttttggttta caaatctatg atcaacttat tccattaaat
2041 agatacatta aaaaaattaa aaactgcaaa aaaaaaaaaa aaactggtgt ttctttttat
2101 aaccccttga aacaagtctc tcacctgagc ctgtctaaac tttcggaggg agtttattat
2161 tgagtcttta tctgtgacag tatttggaga tttagggatt tgatacttag gcctttgaat
2221 tttagaatac aaaaagagaa gcaagccaga catggtggct cacacctgta atcccaatac
2281 tgggaagcca aggtgggagt atcgcttgag cccaggagtt tgagaccgac atgggcaaca
2341 tgacaagacc ccatctctac aaaaaaaatt aaaaaattag ccaggcatgg tggcacatgc
2401 ctactcccag ctcccaagga gactgagatg ggaggatccc tggagccctg aagattgagg 2461 ctacagtgag ccttgattgt gtcactgcac tccagcttgg gtgacagaga ccctgtctcg 2521 agaaatt
PELI2 cDNA sequence 2 (SEQ ID NO: 26)
NM_021255 Homo sapiens pellino homolog 2 (Drosophila) (PELI2), mRNA
1 cagccacgac ggagcagcag cgggactggc cgccccgcgc ccccttcgcc gccgtgccct 61 tccccggcgc gctcaccccg ttctcgggat gggattgtag cggcggcgcg gactcggcgg 121 ggatcgcggc ggaggcggcg gcgtcggcgg cggcgtcggc ggccgagcgg ggctccatgt 181 tttcccctgg ccaggaggaa cactgcgccc ccaataagga gccagtgaaa tacggggagc 241 tggtggtgct cgggtacaat ggtgctttac ccaatggaga tagaggacgg aggaaaagta 301 gatttgccct ctacaagcgg cccaaggcaa atggtgtcaa acccagcacc gtccatgtga 361 tatccacgcc ccaggcatcc aaggctatca gctgcaaagg tcaacacagt atatcctaca 421 ctttgtcaag gaatcagact gtggtggtgg agtacacaca tgataaggat acggatatgt 481 ttcaggtggg cagatcaaca gaaagcccta tcgacttcgt tgtcacagac acgatttctg 541 gcagccagaa cacggacgaa gcccagatca cacagagcac catatccagg ttcgcctgca 601 ggatcgtgtg cgacaggaat gaaccttaca cagcacggat attcgccgcc ggatttgact 661 cttccaaaaa catatttctt ggagaaaagg cagcaaagtg gaaaaacccc gacggccaca 721 tggatgggct cactactaat ggcgtcctgg tgatgcatcc acgagggggc ttcaccgagg 781 agtcccagcc ggggtctgg cgcgagatct ctgtctgtgg agatgtgtac accttgcgag 841 aaaccaggtc ggcccagcaa cgaggaaagc tggtggaaag tgagaccaac gtcctgcagg 901 acggctccct cattgacctg tgtggggcca ctctcctctg gagaacagca gatgggcttt 961 ttcatactcc aactcagaag cacatagaag ccctccggca ggagattaac gccgcccggc
1021 ctcagtgtcc tgtggggctc aacaccctgg ccttccccag catcaacagg aaagaggtgg
1081 tggaggagaa gcagccctgg gcatatctca gttgtggcca cgtgcacggg taccacaact
1141 ggggccatcg gagtgacacg gaggccaacg agagggagtg tcccatgtgc aggactgtgg
1201 gcccctatgt gcctctctgg cttggctgtg aggcaggatt ttatgtagac gcaggaccgc
1261 caactcatgc tttcactccc tgtggacacg tgtgctcgga gaagtctgca aaatactggt
1321 ctcagatccc gttgcctcat ggaactcatg catttcacgc tgcttgccct ttctgtgcta
1381 cacagctggt tggggagcaa aactgcatca aattaatttt ccaaggtcca attgactgac
1441 gcccttgaca gccatctacg actttattaa caggttactg tgaagatttt gccactaact
1501 ctagatttta cctttttgta atgctgttta tcagaggagg gtgacagggg ctggaaataa
1561 agagagggga catggtgatg aaacatggca ggagtgtaac agataccagt ggtgtgttgc
1621 atgctcaaaa cagcagcgtc gtcattgaag tctgcttgat ccaaccataa tatctttgta
1681 ataattggat ttaaaatgct atgcttctat ttttaacctt gggtttttaa ccaagttttt
1741 tttttttttt gtaatcttgg acaagacttt aaatcatatt ttacagatgt agaagaaatt
1801 tattcaaaag tgtgggctca tgaagttcac ttcagtgcag tgtggtgtag gtgttacgcg
1861 aagggcgcac agtgtctaga aatacttgat cgtggctcaa acctgaccag acagcagagg
1921 ggcggctctg tacagtgtga ctggtggaca gatggcctta ggcacaggtg gttttgaaat
1981 ctggggcttt ttctgattta tttttctgac ttgttggggg agagaatatt cataacttgt
2041 gggctttttt tttttttaac ttcagtggaa tttactttag atattcattc atcaaataca
2101 tgggacttca caaacaattt tccataactt tttagcctgt cttttgttat ttctgcctaa
2161 tatgatttgc cccgatactc atcttgcacg gccagaactg tttggttgat taaaatacat
2221 cagctcttaa aaactcatta actgagggta attacagtag tagacatggt ctgggtacta
2281 tactaccatg tttatttgct gactgaatta agatttaaga atgattaaaa ataagctttt
2341 actttttaaa accacttgag gtttcataaa gcttggggtt tttttttttc ctttgttaag
2401 aaagccaacc aatcacaatg atatagtcat tgttgtgcac tcccttttca ccatctgtca
2461 ccttcccttg cagcttaagg agcccagtaa gttttgaaaa tgtttgcgaa tcaaactaaa
2521 tttaagtggg atgattagat atacacaaca ccaagtggta catctgcaga gataattcaa
2581 aattcctgct tttgagagag caaatgagtg tttgctgagg aataattaaa tgagaatttc
2641 ataggagctc caccattcct gttactttca tttcattttg attaataatt cttggatgct
2701 tggcatcgat cgtatcactg ctcctagaag gtaaagatcc tttaggacat gagactggta
2761 gaagctggct gagataaaat aagtatttat ttaaactaat gttctcttaa tttgaccatt
2821 gcagatttgg gtgacttttt tttaaccttt gtacatatac gtaatttata tgattctaat
2881 gtactatatc catacttgaa ttggtttttt cgtattttgc ctactggcaa atattttgcc
2941 tattttcagt cgttctaacc tatttgaata cgcttttcct taaagtgata cgataatatt
3001 actcttgatt gctgctgctt aatttgatgt aatatgttta aagttcagcc tctcagtttt
3061 aatatagctt tatttttcag tggagatcat tgtttaggat gagacatttt tggttttggt
3121 tttgtttggg taaattttaa atggtgtgaa aatcgatgac aacagtcctc ttacagatag
3181 cttgctgtat tctgtatagc ttactctacc tgcagacaga aaatgaaaga aaaaaatgga
3241 cttgcctaga ataatatatt gaatgccttt tgatttagcc agagtctctg atgattagct 3301 ttcgctgata gagtatgtct tttcagcctg taattctttg ggccccaaag aatgacaaag 3361 gaggcactcg ttctcttttc ttgctgtatg cctagaaagt ggttgaagga ttcttgatgc 3421 cctaaaacca tcttgtaagc taaatggtct tgcatccaga aaggccagat tttacctacc 3481 aagaaaaaaa gatatttttc cagagagtta ggtatatcat aattttccat ttcaagtcct 3541 gtttataagt ctagtcattc tgcaacgtga catatccccc aaaatgaagt taccttccaa 3601 gttggacacg tcccgtagtt gggcatatgt ctaactaaaa gtttctgact tttagtaaat 3661 tcagcttaaa tataagttga aatttgggaa ataatttcca agctcttgga aggggtaaca 3721 gtgaaccgcc ctccatgggc tccacatctt ttcctttggc ttccaaagtc aggtcccgcc 3781 caccctgcct aaggaactgc agagaggtgg caaatcagca aaaaggacac caggctcttc 3841 ttggccactt gtaggaagat ccctttacaa ttttgactaa ggagattttt tttttcacag 3901 ttgagttagt ttgtgaaaat aaagaactct gtagctcacc aaggtggaga aacgcaattc 3961 agaaaagtaa tttctccaag gtcacttctt tttttatgtc ttgccatcac tttaaaggac 4021 tagccccact cccccatgtg tatacacaag gaaattgcag accaattagt tgtcttggcc 4081 tgactctaat gccttttgca agtagctttc cagaagtaaa agtcccagtg atgtattccc 4141 atagaaatat ttttcagttg tttatgtcgt ttactacaaa aaaaaagatt cagagtggat 4201 ggagtacaac tctgagtatt tttctagtcc ggaatttttt attaataatc ggtgctgccg 4261 ggtcatgcat gctgcaactc tcaacatttc ccttatttgg ttcagctttt agcaaaaagg 4321 gctacagttc accctgcaga gtattaaggt ttctggattt ttttctccca actgtggccc 4381 aaaagaatta aaatctgtta atataaatag agaacatatt tatcattcct cgatagttaa 4441 ttatagactt tggtaccttt gtgcctcagg gaagccacgt gatataactg gttatagaat 4501 ttcagggtta gggtttaaag aaaggagaaa gccattggaa aaatgatggg ctccattaag 4561 gagactaatg aatctggatg cagaaatatg tcagaaactg gcataaacat gattgtagta 4621 gaatttattt tccagtacca atagggaaat tattttaagt tattacattt actgtattgg 4681 gaaacttgag gagaactctt tagttcataa agcttcaatg tctttttttt tttttttcat 4741 ggaaaaactc aaacctctgt tatttgggag ctcagtattg tgtggacact tacgagagtt 4801 ttctgcttaa ttgaagtgta atataggttg tagaattgtt acctgcagtt ctatggtttt 4861 gtttcacttc ttttcttttt taaagccatt ctgttctttg gatgtgcttg aaagggtgtg 4921 tgattacacc attgttaatg ctgggtaaaa actatcttct tgcagccttg cctcataaca 4g81 gtggaatttc tgatagacaa accacaggac tttgatttta agccaaatcc atctccatcc 5041 ctttactgtc aatcttctgt cccagtagtt tagcctttgt ggcttaggtt atgatgcgcc 5101 tccttctgtg cgaccaatga gacgacttca gcatcttttt aaaataatct aagcatcatt 5161 gaagcagtaa cacaaaaaaa aggttcagta ttttcttttt agtataactt acatcctttc 5221 aaataagtct ttgccctcat gaagaatccc tagaggaaga taaggaaaat aagtattttc 5281 cagttttgct tgacagtttc taaacaaaca aaaataaact caatgaaagg aaagatgttt 5341 ctttttagct gagatgacag attgcttctc tgtattaaat agtctagaag ttaaggggat 5401 ggtcacattt accatgtatt gtgttattag cagttaaatt ttatgaatat gtttgtaaaa 5461 ttgttgtttt atatttcatg tcaaattgaa aagtttattt cttcactatt gtacctgtgg 5521 aaatacaagc cattttacag gaaaaaatct tcaaaaacta ttaaatggat atcagcctga 5581 aaaaaaaaaa aaaaaag
LOXLl cDNA sequence 2 (SEQ ID NO: 27)
NM_005576 Homo sapiens lysyl oxidase-like 1 (LOXLl), mRNA
1 gccagccgag cggccagcca gtgcggggct ggccatgtaa ggcccacagg cggtcctgcc 61 cgcccggtgc cctgcggaga gcctcgtgca gccctgggca ccgcccctgc cctgccctga 121 ccccttggcc ttgaaatgct gtcatcggag gagccgtccc gctcgggaca aggccagcat 181 ggacaaagct agagctgggg caagcaagga gccttcctgt cctcgaggcc gtgggaagag 241 aagcacgccc agggggccac tcctgagagc ctctctgtcc accaggcctc tgcagagggg 301 tcaccatggc tctggcccga ggcagccggc agctgggggc cctggtgtgg ggcgcctgcc 361 tgtgcgtgct ggtgcacggg cagcaggcgc agcccgggca gggctcggac cccgcccgct 421 ggcggcagct gatccagtgg gagaacaacg ggcaggtgta cagcttgctc aactcgggct 481 cagagtacgt gccggccgga cctcagcgct ccgagagtag ctcccgggtg ctgctggccg 541 gcgcgcccca ggcccagcag cggcgcagcc acgggagccc ccggcgtcgg caggcgccgt 601 ccctgcccct gccggggcgc gtgggctcgg acaccgtgcg cggccaggcg cggcacccat 661 tcggctttgg ccaggtgccc gacaactggc gcgaggtggc cgtcggggac agcacgggca 721 tggccctggc ccgcacctcc gtctcccagc aacggcacgg gggctccgcc tcctcggtct 781 cggcttcggc cttcgccagc acctaccgcc agcagccctc ctacccgcag cagttcccct 841 acccgcaggc gcccttcgtc agccagtacg agaactacga ccccgcgtcg cggacctacg 901 accagggttt cgtgtactac cggcccgcgg gcggcggcgt gggcgcgggg gcggcggccg 961 tggcctcggc gggggtcatc tacccctacc agccccgggc gcgctacgag gagtacggcg 1021 gcggcgaaga gctgcccgag tacccgcctc agggcttcta cccggccccc gagaggccct 1081 acgtgccgcc gccgccgccg ccccccgacg gcctggaccg ccgctactcg cacagtctgt 1141 acagcgaggg cacccccggc ttcgagcagg cctaccctga ccccggtccc gaggcggcgc 1201 aggcccatgg cggagaccca cgcctgggct ggtacccgcc ctacgccaac ccgccgcccg 1261 aggcgtacgg gccgccgcgc gcgctggagc cgccctacct gccggtgcgc agctccgaca 1321 cgcccccgcc gggtggggag cggaacggcg cgcagcaggg ccgcctcagc gtaggcagcg 1381 tgtaccggcc caaccagaac ggccgcggtc tccctgactt ggtcccagac cccaactatg 1441 tgcaagcatc cacttatgtg cagagagccc acctgtactc cctgcgctgt gctgcggagg 1501 agaagtgtct ggccagcaca gcctatgccc ctgaggccac cgactacgat gtgcgggtgc 1561 tactgcgctt cccccagcgc gtgaagaacc agggcacagc agacttcctc cccaaccggc 1621 cacggcacac ctgggagtgg cacagctgcc accagcatta ccacagcatg gacgagttca 1681 gccactacga cctactggat gcagccacag gcaagaaggt ggccgagggc cacaaggcca 1741 gtttctgcct ggaggacagc acctgtgact tcggcaacct caagcgctat gcatgcacct 1801 ctcataccca gggcctgagc ccaggctgct atgacaccta caatgcggac atcgactgcc 1861 agtggatcga cataaccgac gtgcagcctg ggaactacat cctcaaggtg cacgtgaacc 1921 caaagtatat tgttttggag tctgacttca ccaacaacgt ggtgagatgc aacattcact 1981 acacaggtcg ctacgtttct gcaacaaact gcaaaattgt ccaatcctga tctccgggag 2041 ggacagatgg ccaatctctc cccttccaaa gcaggccctg ctccccgggc agcctcccgc 2101 cgaggggccc agcccccaac ccacaggcag ggaggggcat ccctccctgc cggcctcagg 2161 gagcgaacgt ggatgaaaac cacagggatt ccggatgcca gaccccattt tatacttcac 2221 ttttctctac agtgttgttt tgttgttgtt ggtttttatt ttttatactt tggccatacc 2281 acagagctag attgcccagg tctgggctga ataaaacaag gtttttct
CASPR4 cDNA sequence 1 (SEQ ID NO: 28)
NM_033401 Homo sapiens cell recognition protein CASPR4 (CASPR4), transcript variant 1, mRNA
1 tatataattt tatgattttt aaagtatttt catattctcc tgtctttaag ttttttcttt 61 tctcattgaa cttactagac ttctagtaag ccctggaagt agtaggcata tttttagaga 121 tcttagatcc tagtttttga tgttgttgtt ttacttgttg gttgttttgt ctattgattc 181 cacgaaagcc tcagcactaa ctaaccctaa cgtggcattg ttcctcctgg cagatgactg 241 tgatgatcct cttgtgtctg ccttgcctca ggcatccttc agcagttctt ccgagctctc 301 cagcagtcat ggtcctggat ttgcaaggct gaatagaaga gatggagctg gtggctggtc 361 tccacttgtg tctaacaaat accagtggtt gcagattgac cttggagaga gaatggaggt 421 caccgctgtg gccactcaag ggggatatgg tagctccaac tgggtgacca gctacctcct 481 gatgttcagt gatagtggct ggaactggaa acaatatcgc caagaggaca gcatctgggg 541 tttttcagga aatgcaaatg cagacagtgt tgtgtactat agactccagc cttctatcaa 601 agccagattt ctgcgcttca tccctttgga atggaacccc aagggcagaa ttggaatgcg 661 aatcgaagtg ttcggatgtg catacagatc agaagtggtt gatcttgatg gaaaaagttc 721 ccttctctac agatttgatc aaaaatccct gagcccaata aaagacatta tttctttgaa 781 attcaaaacc atgcagagtg atgggattct actccacagg gaagggccaa atggagatca 841 catcacactg caattaagaa gagcaagact ctttttactt attaattcag gtgaagctaa 901 actgccttcc acttccaccc tggtcaatct caccctgggc agcctgctag atgatcagca 961 ttggcattca gtgctcatcc agcgtttggg caaacaagtc aacttcacag tggacgaaca
1021 caggcatcat ttccatgcac ggggagaatt caatctcatg aatcttgatt atgagatcag
1081 ctttggaggg attccagcac ctggaaaatc agtgtcattc ccacatagaa attttcatgg
1141 atgtttagaa aatctctatt ataatggagt ggatatcatt gatttggcca agcagcaaaa
1201 accacagatc attgctatgg gaaatgtgtc attttcttgt tcacaaccac aatctatgcc
1261 cgtgactttt ctgagctcca ggagttattt agcactgcca gacttctctg gagaggagga
1321 ggtttctgcc acttttcaat ttcgaacttg gaataaggca gggcttctgc tgttcagtga
1381 acttcagctg atttcagggg gtatcctcct ctttctgagt gatggaaaac ttaagtcgaa
1441 tctctaccag ccaggaaaat tacccagtga catcacagca ggtgtcgaat taaatgatgg
1501 gcagtggcat tctgtctctt tatctgctaa aaagaatcac ttgagtgtgg cggtggacgg
1561 ccagatggct tctgctgctc ctctgctggg gcctgagcag atttattcgg gtggcaccta
1621 ttattttgga ggttgtcctg acaaaagctt tggatccaaa tgtaaaagtc cacttggtgg
1681 atttcaggga tgtatgaggc tcatttctat cagcggcaaa gtggtagatc tgatttcagt
1741 tcagcagggg tcccttggga acttcagtga ccttcagata gactcatgtg gcatctcaga
1801 caggtgtttg cccaactatt gtgaacacgg tggggagtgt tcccagtcct ggagcacctt
1861 tcattgtaac tgtaccaaca ctggttacag aggagctact tgccataact ctatctatga
1921 gcagtcatgt gaagcctata agcacagagg aaatacttca gggttttact atatagattc
1981 agatggaagt ggtcccctgg aaccatttct tctatattgc aatatgaccg aaactgcatg
2041 gaccatcata cagcacaacg gctctgactt aacaagagtc agaaatacta atccagagaa 2101 cccatatgct gggtttttcg agtatgtggc cagcatggag caacttcagg ccactattaa 2161 ccgtgcagag cactgtgaac aggagtttac ttattactgc aagaagtcac ggctggtcaa 2221 taagcaagat ggaacccctc tgagttggtg ggtaggaaga accaatgaaa cgcaaaccta 2281 ctggggaggt tcttcgcctg atcttcaaaa atgtacttgt ggattagagg gaaactgcat 2341 tgattctcag tattactgca attgtgatgc tgaccggaat gaatggacca atgacactgg 2401 attgcttgct tataaagaac atcttccagt aactaagatc gtgattacag acacaggccg 2461 actgcattca gaagcagctt ataaactggg gcctctgctc tgccggggag acagatcatt 2521 ttggaattca gcttcctttg ataccgaggc ttcatatctt cattttccta ccttccacgg 2581 agaacttagc gcggatgtat ctttcttttt taagacaaca gcttcatctg gggtattttt 2641 agagaacttg gggattgctg attttatacg gatagagctt cgctctccga cagtagtgac 2701 tttttcattt gatgtgggga atgggccttt tgaaatctca gtgcagtcac ccacccactt 2761 caacgacaac cagtggcacc atgtgagggt tgaaaggaac atgaaggagg cctcccttca 2821 agtggatcag ctgacaccaa agacacagcc cgcccccgct gatgggcatg tcctgttaca 2881 gctcaacagt cagctcttcg tgggtggaac ggccaccaga cagagaggct ttctgggctg 2941 cattcggtct ctgcagttga atgggatgac cctggatttg gaagaaagag cccaggtgac 3001 tccagaagtg cagccaggtt gtaggggaca ttgcagcagc tatgggaagt tatgccgcaa 3061 tggagggaaa tgcagagaaa gacccattgg gttcttttgt gactgcactt tctctgcata 3121 cacagggcca ttctgctcaa atgagatttc tgcatatttt ggatctggct catccgtgat 3181 atacaatttt caagaaaatt atcttttaag taaaaactcc agctcccacg ctgcttcatt 3241 tcatggtgat atgaagctga gcagagaaat gatcaaattt agtttccgaa caacacgaac 3301 accaagcttg ctgctttttg tgagctcctt ttacaaagaa tacctttctg tgatcattgc 3361 caaaaatgga agtttgcaga tcaggtacaa gttaaataaa tatcaagagc ctgatgttgt 3421 taactttgat tttaaaaaca tggctgatgg acaacttcac cacataatga ttaacagaga 3481 agaaggagtg gtctttatag agattgacga taatagaagg agacaagttc acctgtcatc 3541 aggcacagaa ttcagtgcag tcaaatctct ggtattgggc aggattttag aacacagtga 3601 tgtggaccag gagactgcac tggcaggtgc gcagggcttc acaggctgcc tctctgcagt 3661 gcagctcagc cacgtggccc ctctgaaggc agctctgcac cccagccacc cagaccctgt 3721 cactgttaca ggacacgtga ccgagtccag ctgtatggcc cagcctggca ctgatgccac 3781 atcaagggaa aggacacact cgtttgcaga tcattctgga acaatagatg acagagagcc 3841 ccttgctaat gcaatcaaaa gtgactctgc agtaattgga ggtctgatag ctgttgtgat 3901 ttttatcttg ctttgcatca ctgccatagc tgttcgcatt tatcagcaga aaaggttata 3961 taaaagaagt gaggcaaaaa ggtcagagaa tgtagacagt gctgaggctg ttctgaaaag 4021 tgagcttaat atacaaaatg cagtcaatga aaatcagaaa gagtacttct tctgattggc 4081 agctatgatt taacataaaa ttatgatagt ttgttttaat agccaggggt tctcaatgga 4141 aaaacgaatg ctcttacact gaatgtacag gcagtgggct tgcagcactg ccatcttgcc 4201 atgtacaggc ttggggtggc tccaggaagc ctcgtccagt gatatatttc tcatagcatt 4261 cattctatgg aacaagaaat tagatattgc tgttaatttt caactgttct ggtatgatct 4321 aaaacaagtt taacctgctt aatggctaca gtttttacat gtgaaaactg tagccttggt 4381 ctcttaacca tgtaatacat aagttttgtt agaggtaaaa attaaatttg gactataatg 4441 tccttgcttt atttg
CASPR4 cDNA sequence 2 fSEO ID NO: 29)
NM_138994 Homo sapiens cell recognition protein CASPR4 (CASPR4), transcript variant 2, mRNA
1 ctcattttct cttgcagccg ccatgattct gaggccttcc cagctatgtg gaactatgac 61 tgtgatgatc ctσttgtgtc tgccttgcct caggcatcct tcagcagttc ttccgagctc 121 tccagcagtc atggtcctgg atttgcaagg ctgaatagaa gagatggagc tggtggctgg 181 tctccacttg tgtctaacaa ataccagtgg ttgcagattg accttggaga gagaatggag 241 gtcaccgctg tggccactca agggggatat ggtagctcca actgggtgac cagctacctc 301 ctgatgttca gtgatagtgg ctggaactgg aaacaatatc gccaagagga cagcatctgg 361 ggtttttcag gaaatgcaaa tgcagacagt gttgtgtact atagactcca gccttctatc 421 aaagccagat ttctgcgctt catccctttg gaatggaacc ccaagggcag aattggaatg 481 cgaatcgaag tgttcggatg tgcatacaga tcagaagtgg ttgatcttga tggaaaaagt 541 tcccttctct acagatttga tcaaaaatcc ctgagcccaa taaaagacat tatttctttg 601 aaattcaaaa ccatgcagag tgatgggatt ctactccaca gggaagggcc aaatggagat 661 cacatcacac tgcaattaag aagagcaaga ctctttttac ttattaattc aggtgaagct 721 aaactgcctt ccacttccac cctggtcaat ctcaccctgg gcagcctgct agatgatcag 781 cattggcatt cagtgctcat ccagcgtttg ggcaaacaag tcaacttcac agtggacgaa 841 cacaggcatc atttccatgc acggggagaa ttcaatctca tgaatcttga ttatgagatc 901 agctttggag ggattccagc acctggaaaa tcagtgtcat tcccacatag aaattttcat 961 ggatgtttag aaaatctcta ttataatgga gtggatatca ttgatttggc caagcagcaa 1021 aaaccacaga tcattgctat gggaaatgtg tcattttctt gttcacaacc acaatctatg 1081 cccgtgactt ttctgagctc caggagttat ttagcactgc cagacttctc tggagaggag 1141 gaggtttctg ccacttttca atttcgaact tggaataagg cagggcttct gctgttcagt 1201 gaacttcagc tgatttcagg gggtatcctc ctctttctga gtgatggaaa acttaagtcg 1261 aatctctacc agccaggaaa attacccagt gacatcacag caggtgtcga attaaatgat 1321 gggcagtggc attctgtctc tttatctgct aaaaagaatc acttgagtgt ggcggtggac 1381 ggccagatgg cttctgctgc tcctctgctg gggcctgagc agatttattc gggtggcacc 1441 tattattttg gaggttgtcc tgacaaaagc tttggatcca aatgtaaaag tccacttggt 1501 ggatttcagg gatgtatgag gctcatttct atcagcggca aagtggtaga tctgatttca 1561 gttcagcagg ggtcccttgg gaacttcagt gaccttcaga tagactcatg tggcatctca 1621 gacaggtgtt tgcccaacta ttgtgaacac ggtggggagt gttcccagtc ctggagcacc 1681 tttcattgta actgtaccaa cactggttac agaggagcta cttgccataa ctctatctat 1741 gagcagtcat gtgaagccta taagcacaga ggaaatactt cagggtttta ctatatagat 1801 tcagatggaa gtggtcccct ggaaccattt cttctatatt gcaatatgac cgaaactgca 1861 tggaccatca tacagcacaa cggctctgac ttaacaagag tcagaaatac taatccagag 1921 aacccatatg ctgggttttt cgagtatgtg gccagcatgg agcaacttca ggccactatt 1981 aaccgtgcag agcactgtga acaggagttt acttattact gcaagaagtc acggctggtc 2041 aataagcaag atggaacccc tctgagttgg tgggtaggaa gaaccaatga aacgcaaacc 2101 tactggggag gttcttcgcc tgatcttcaa aaatgtactt gtggattaga gggaaactgc 2161 attgattctc agtattactg caattgtgat gctgaccgga atgaatggtg atttccatac 2221 gatttcttta tgcaagaaaa agttcattta aaaaaattaa tcactcaaag tatgtatagc 2281 tagccagata ctgaacaagt tagtgcaatg aagtaattaa ataaaggttt gttttaatg
GPR50 cDNA sequence (SEQ ID "NO: 30)
NM_004224 Homo sapiens G protein-coupled receptor 50 (GPR50), mRNA
1 tgtttgctgt ctggacctgg ctgctgatcc tgagcctgct gggagatctt aacgatcccc 61 aggagcaaca tggggcccac cctagcggtt cccaccccct atggctgtat tggctgtaag 121 ctaccccagc cagaataccc accggctcta atcatcttta tgttctgcgc gatggttatc 181 accatcgttg tagacctaat cggcaactcc atggtcattt tggctgtgac gaagaacaag 241 aagctccgga attctggcaa catcttcgtg gtcagtctct ctgtggccga tatgctggtg 301 gccatctacc catacccttt gatgctgcat gccatgtcca ttgggggctg ggatctgagc 361 cagttacagt gccagatggt cgggttcatc acagggctga gtgtggtcgg ctccatcttc 421 aacatcgtgg caatcgctat caaccgttac tgctacatct gccacagcct ccagtacgaa 481 cggatcttca gtgtgcgcaa tacctgcatc tacctggtca tcacctggat catgaccgtc 541 ctggctgtcc tgcccaacat gtacattggc accatcgagt acgatcctcg cacctacacc 601 tgcatcttca actatctgaa caaccctgtc ttcactgtta ccatcgtctg catccacttc 661 gtcctccctc tcctcatcgt gggtttctgc tacgtgagga tctggaccaa agtgctggcg 721 gcccgtgacc ctgcagggca gaatcctgac aaccaacttg ctgaggttcg caattttcta 781 accatgtttg tgatcttcct cctctttgca gtgtgctggt gccctatcaa cgtgctcact 841 gtcttggtgg ctgtcagtcc gaaggagatg gcaggcaaga tccccaactg gctttatctt 901 gcagcctact tcatagccta cttcaacagc tgcctcaacg ctgtgatcta cgggctcctc 961 aatgagaatt tccgaagaga atactggacc atcttccatg ctatgcggca ccctatcata
1021 ttcttccctg gcctcatcag tgatattcgt gagatgcagg aggcccgtac cctggcccgc
1081 gcccgtgccc atgctcgcga ccaagctcgt gaacaagacc gtgcccatgc ctgtcctgct
1141 gtggaggaaa ccccgatgaa tgtccggaat gttccattac ctggtgatgc tgcagctggc
1201 caccccgacc gtgcctctgg ccaccctaag ccccattcca gatcctcctc tgcctatcgc
1261 aaatctgcct ctacccacca σaagtctgtc tttagccact ccaaggctgc ctctggtcac
1321 ctcaagcctg tctctggcca ctccaagcct gcctctggtc accccaagtc tgccactgtc
1381 taccctaagc ctgcctctgt ccatttcaag ggtgactctg tccatttcaa gggtgactct
1441 gtccatttca agcctgactc tgttcatttc aagcctgctt ccagcaaccc caagcccatc
1501 actggccacc atgtctctgc tggcagccac tccaagtctg ccttcagtgc tgccaccagc
1561 caccctaaac ccatcaagcc agctaccagc catgctgagc ccaccactgc tgactatccc
1621 aagcctgcca ctaccagcca ccctaagccc gctgctgctg acaaccctga gctctctgcc
1681 tcccattgcc ccgagatccc tgccattgcc caccctgtgt ctgacgacag tgacctccct
1741 gagtcggcct ctagccctgc cgctgggccc accaagcctg ctgccagcca gctggagtct
1801 gacaccatcg ctgaccttcc tgaccctact gtagtcacta ccagtaccaa tgattaccat
1861 gatgtcgtgg ttgttgatgt tgaagatgat cctgatgaaa tggctgtgtg aaaaatgctc
1921 tcgtaggtgg ccaggcagt APOL3 cDNA sequence 1 (SEQ ID NO: 31)
NM_145640 Homo sapiens apolipoprotein L, 3 (APOL3), transcript variant alpha/d, mRNA
1 agcaggaggg tgggaccaag ggtgctgctg gaccaaggat gggactgggc caagggtggg 61 gctgggaagc atcctgtttt gcatgtttga tcaggagctg ctgccaagtt gtgactttca 121 ctttcccttt tgggttccag ggtatatctc agagcctgga gaacgtgtct ggttattatg 181 cagatgcacg gctggaggtg ggatccacac agctcagaac agctggatct tgctcacact 241 ctttcaagag aagcttcctt gaaaagaaac gctttactga agaggccacc aaatacttcc 301 gggagagagt cagcccagtg catctgcaaa tcctgctgac taacaatgaa gcctggaaga 361 gattcgtgac tgcggctgaa ttgcccaggg atgaggcaga tgctctctac gaagctctga 421 agaagcttag aacatatgca gctattgagg acgaatatgt gcagcagaaa gatgagcagt 481 ttagggaatg gtttttgaaa gagtttcccc aagtcaagag gaagatccag gagtccatag 541 aaaagcttcg tgcccttgca aatggtattg aagaggtcca cagaggctgc accatctcca 601 atgtggtgtc cagctccact ggcgctgcct ctggcatcat gtcccttgct ggtcttgttt 661 tggcaccatt tacagcaggg acgagtctgg cccttactgc agctggggta gggctgggag 721 cagcgtctgc tgtgactggg atcaccacca gcatcgtgga gcactcatac acatcatcag 781 cagaagctga agccagcagg ctgactgcaa ccagcattga ccgattgaag gtatttaagg 841 aagttatgcg tgacatcaca cccaacttac tttcccttct taataattat tacgaagcca 901 cacaaaccat tgggagtgaa atccgtgcca tcaggcaagc cagagccagg gcccgactcc 961 ctgtgaccac ctggcgaatc tcagctggaa gtggtggtca agcagagaga acgattgcag
1021 gcaccacccg ggcagtgagc agaggagccc ggatcctgag tgcgaccact tcaggcatct
1081 tccttgcact ggatgtggtc aaccttgtat acgagtcaaa gcacttgcat gagggggcaa
1141 agtctgcatc tgctgaggag ctgaggcggc aggctcagga gctggaggag aatctaatgg
1201 agctcactca gatctatcag cgtctgaatc catgccatac ccactgaccc cagaccagtg
1261 cagccagcag gggaggtgag ccatacacag gccacgacaa aatgcaggca ttttattagg
1321 gggataaaga gggcaaggta aagtttatgg agctgagtgt tagtgacttt ggcatttctg
1381 tagctgagca cagcagggga ggggttaatg cagatggcaa gtgcaccaag gagaaggcag
1441 gaatgctgga gcctggaata agggaggaga ggggactgga gagtgtgggg aataggaaga
1501 agaaatttcc tttagactaa cgaatatatt ggggggagga atagagggga ggtgtgcagg
1561 aaccagcaat gagaaggcca ggaaaagaaa gagctgaaaa tgcagaaagc cgaagagtta
1621 gaacttttgg atacagcaga agaaacagcg gctccactac cgacctgccc ccggttcgat
1681 gtccttccaa gaatgaagtc tttccctggt gatggtcccc tgccctgtct ttccagcatc
1741 cactctgtct tgtcctcctg gaagtgtatc tcagtcagcc agtggcttct tgatgatggc
1801 ggtggaggtg gtggttgtag tgtgatggat cccctttagg ttatttaggg gtatatgtcc
1861 cctgcttgaa ccctgaaggc caggtaatga gccatggcca ttgtccccag ctgaggacca
1921 ggtgtctcta aaaacccaaa catcctggag agtatgcgag aacctaccaa gaaaaacagt
1981 ctcattactc atatacagca ggcaaagaga cagaaaatta actgaaaagc agtttagaga
2041 ctgggggagg ccggatctct agagccatcc tgctgagtgc cctgtgtgta agtcctaata
2101 aactcaccta ctcaccaa
APOL3 cDNA sequence 2 (SEQ ID NO: 32)
NM_014349 Homo sapiens apolipoprotein L, 3 (APOL3), transcript variant alpha/a, mRNA
1 agcaggaggg tgggaccaag ggtgctgctg gaccaaggat gggactgggc caagggtggg 61 gctgggaagc atcctgtttt gcatgtttga tcaggagctg ctgccaagtt gtgactttca 121 ctttcccttt tgggttccag ggtatatctc agagcctgga gaacgtgtct ggttattatg 181 cagatgcacg gctggaggtg ggatccacac agctcagaac agctggatct tgctcacact 241 ctttcaagag aagcttcctt ggacaaaagg accctgcctt ggtgtgagag tgagggcaga 301 gggagctgga gcaagtagaa tttctctaaa taccagctgg ctggggccca ggagattaaa 361 aaacaccggg ctaggttggt cttggcattt gctgacacgc aaagggattg cagagatcca 421 gcccctccaa cctccctctg tccacaggtg gctcacattc agtcccacaa tttgctttct 481 cctcctcaag ggttaagaaa aaaaacgaac ccttccagtc aggtcagtga ctggagagct 541 ccatggaaag tctctcagtg acctggctgc tggcaccatg gactcagaaa agaaacgctt 601 tactgaagag gccaccaaat acttccggga gagagtcagc ccagtgcatc tgcaaatcct 661 gctgactaac aatgaagcct ggaagagatt cgtgactgcg gctgaattgc ccagggatga 721 ggcagatgct ctctacgaag ctctgaagaa gcttagaaca tatgcagcta ttgaggacga 781 atatgtgcag cagaaagatg agcagtttag ggaatggttt ttgaaagagt ttccccaagt 841 caagaggaag atccaggagt ccatagaaaa gcttcgtgcc cttgcaaatg gtattgaaga 901 ggtccacaga ggctgcacca tctccaatgt ggtgtccagc tccactggcg ctgcctctgg 961 catcatgtcc cttgctggtc ttgttttggc accatttaca gcagggacga gtctggccct 1021 tactgcagct ggggtagggc tgggagcagc gtctgctgtg actgggatca ccaccagcat 1081 cgtggagcac tcatacacat catcagcaga agctgaagcc agcaggctga ctgcaaccag 1141 cattgaccga ttgaaggtat ttaaggaagt tatgcgtgac atcacaccca acttactttc 1201 ccttcttaat aattattacg aagccacaca aaccattggg agtgaaatcc gtgccatcag 1261 gcaagccaga gccagggccc gactccctgt gaccacctgg cgaatctcag ctggaagtgg 1321 tggtcaagca gagagaacga ttgcaggcac cacccgggca gtgagcagag gagcccggat 13 81 cctgagtgcg accacttcag gcatcttcct tgcactggat gtggtcaacc ttgtatacga 1441 gtcaaagcac ttgcatgagg gggcaaagtc tgcatctgct gaggagctga ggcggcaggc 1501 tcaggagctg gaggagaatc taatggagct cactcagatc tatcagcgtc tgaatccatg 1561 ccatacccac tgaccccaga ccagtgcagc cagcagggga ggtgagccat acacaggcca 1621 cgacaaaatg caggcatttt attaggggga taaagagggc aaggtaaagt ttatggagct 1681 gagtgttagt gactttggca tttctgtagc tgagcacagc aggggagggg ttaatgcaga 1741 tggcaagtgc accaaggaga aggcaggaat gctggagcct ggaataaggg aggagagggg 1801 actggagagt gtggggaata ggaagaagaa atttccttta gactaacgaa tatattgggg 1861 ggaggaatag aggggaggtg tgcaggaacc agcaatgaga aggccaggaa aagaaagagc 1921 tgaaaatgca gaaagccgaa gagttagaac ttttggatac agcagaagaa acagcggctc 1981 cactaccgac ctgcccccgg ttcgatgtcc ttccaagaat gaagtctttc cctggtgatg 2041 gtcccctgcc ctgtctttcc agcatccact ctgtcttgtc ctcctggaag tgtatctcag 2101 tcagccagtg gcttcttgat gatggcggtg gaggtggtgg ttgtagtgtg atggatcccc 2161 tttaggttat ttaggggtat atgtcccctg cttgaaccct gaaggccagg taatgagcca 2221 tggccattgt ccccagctga ggaccaggtg tctctaaaaa cccaaacatc ctggagagta 2281 tgcgagaacc taccaagaaa aacagtctca ttactcatat acagcaggca aagagacaga 2341 aaattaactg aaaagcagtt tagagactgg gggaggccgg atctctagag ccatcctgct 2401 gagtgccctg tgtgtaagtc ctaataaact cacctactca ccaa
APOL3 cDNA sequence 3 (SEQ ID NO: 33)
N _030644 Homo sapiens apolipoprotein L, 3 (APOL3), transcript variant alpha/b, mRNA 1 agcaggaggg tgggaccaag ggtgctgctg gaccaaggat gggactgggc caagggtggg 61 gctgggaagc atcctgtttt gcatgtttga tcaggagctg ctgccaagtt gtgactttca 121 ctttcccttt tgggttccag ggtatatctc agagcctgga gaacgtgtct ggttattatg 181 cagatgcacg gctggaggtg ggatccacac agctcagaac agctggatct tgctcacact 241 ctttcaagag aagcttcctt ggacaaaagg accctgcctt ggtgtgagag tgagggcaga 301 gggagctgga gcaagtagaa tttctctaaa taccagctgg ctggggccca ggagattaaa 361 aaacaccggg ctagggttaa gaaaaaaaac gaacccttcc agtcaggtca gtgactggag 421 agctccatgg aaagtctctc agtgacctgg ctgctggcac catggactca gaaaagaaac 481 gctttactga agaggccacc aaatacttcc gggagagagt cagcccagtg catctgcaaa 541 tcctgctgac taacaatgaa gcctggaaga gattcgtgac tgcggctgaa ttgcccaggg 601 atgaggcaga tgctctctac gaagctctga agaagcttag aacatatgca gctattgagg 661 acgaatatgt gcagcagaaa gatgagcagt ttagggaatg gtttttgaaa gagtttcccc 721 aagtcaagag gaagatccag gagtccatag aaaagcttcg tgcccttgca aatggtattg 781 aagaggtcca cagaggctgc accatctcca atgtggtgtc cagctccact ggcgctgcct 841 ctggcatcat gtcccttgct ggtcttgttt tggcaccatt tacagcaggg acgagtctgg 901 cccttactgc agctggggta gggctgggag cagcgtctgc tgtgactggg atcaccacca 961 gcatcgtgga gcactcatac acatcatcag cagaagctga agccagcagg ctgactgcaa
1021 ccagcattga ccgattgaag gtatttaagg aagttatgcg tgacatcaca cccaacttac
1081 tttcccttct taataattat tacgaagcca cacaaaccat tgggagtgaa atccgtgcca
1141 tcaggcaagc cagagccagg gcccgactcc ctgtgaccac ctggcgaatc tcagctggaa
1201 gtggtggtca agcagagaga acgattgcag gcaccacccg ggcagtgagc agaggagccc
1261 ggatcctgag tgcgaccact tcaggcatct tccttgcact ggatgtggtc aaccttgtat
1321 acgagtcaaa gcacttgcat gagggggcaa agtctgcatc tgctgaggag ctgaggcggc
1381 aggctcagga gctggaggag aatctaatgg agctcactca gatctatcag cgtctgaatc
1441 catgccatac ccactgaccc cagaccagtg cagccagcag gggaggtgag ccatacacag
1501 gccacgacaa aatgcaggca ttttattagg gggataaaga gggcaaggta aagtttatgg
1561 agctgagtgt tagtgacttt ggcatttctg tagctgagca cagcagggga ggggttaatg
1621 cagatggcaa gtgcaccaag gagaaggcag gaatgctgga gcctggaata agggaggaga
1681 ggggactgga gagtgtgggg aataggaaga agaaatttcc tttagactaa cgaatatatt
1741 ggggggagga atagagggga ggtgtgcagg aaccagcaat gagaaggcca ggaaaagaaa
1801 gagctgaaaa tgcagaaagc cgaagagtta gaacttttgg atacagcaga agaaacagcg
1861 gctccactac cgacctgccc ccggttcgat gtccttccaa gaatgaagtc tttccctggt 1921 gatggtcccc tgccctgtct ttccagcatc cactctgtct tgtcctcctg gaagtgtatc 1981 tcagtcagcc agtggcttct tgatgatggc ggtggaggtg gtggttgtag tgtgatggat 2 041 cccctttagg ttatttaggg gtatatgtcc cctgcttgaa ccctgaaggc caggtaatga 2101 gccatggcca ttgtccccag ctgaggacca ggtgtctcta aaaacccaaa catcctggag 2161 agtatgcgag aacctaccaa gaaaaacagt ctcattactc atatacagca ggcaaagaga 2221 cagaaaatta actgaaaagc agtttagaga ctgggggagg ccggatctct agagccatcc 2281 tgctgagtgc cctgtgtgta agtcctaata aactcaccta ctcaccaa
ΛPOL3 cDNA sequence 4 fSEO ID NO: 34)
NM_030644 Homo sapiens apolipoprotein L, 3 (APOL3), transcript variant alpha/c, mRNA 1 agcaggaggg tgggaccaag ggtgctgctg gaccaaggat gggactgggc caagggtggg 61 gctgggaagc atcctgtttt gcatgtttga tcaggagctg ctgccaagtt gtgactttca 121 ctttcccttt tgggttccag ggtatatctc agagcctgga gaacgtgtct ggttattatg 181 cagatgcacg gctggaggtg ggatccacac agctcagaac agctggatct tgctcacact 241 ctttcaagag aagcttcctt gggttaagaa aaaaaacgaa cccttccagt caggtcagtg 301 actggagagc tccatggaaa gtctctcagt gacctggctg ctggcaccat ggactcagaa 361 aagaaacgct ttactgaaga ggccaccaaa tacttccggg agagagtcag cccagtgcat 421 ctgcaaatcc tgctgactaa caatgaagcc tggaagagat tcgtgactgc ggctgaattg 481 cccagggatg aggcagatgc tctctacgaa gctctgaaga agcttagaac atatgcagct 541 attgaggacg aatatgtgca gcagaaagat gagcagttta gggaatggtt tttgaaagag 601 tttccccaag tcaagaggaa gatccaggag tccatagaaa agcttcgtgc ccttgcaaat 661 ggtattgaag aggtccacag aggctgcacc atctccaatg tggtgtccag ctccactggc 721 gctgcctctg gcatcatgtc ccttgctggt cttgttttgg caccatttac agcagggacg 781 agtctggccc ttactgcagc tggggtaggg ctgggagcag cgtctgctgt gactgggatc 841 accaccagca tcgtggagca ctcatacaca tcatcagcag aagctgaagc cagcaggctg 901 actgcaacca gcattgaccg attgaaggta tttaaggaag ttatgcgtga catcacaccc 961 aacttacttt cccttcttaa taattattac gaagccacac aaaccattgg gagtgaaatc
1021 cgtgccatca ggcaagccag agccagggcc cgactccctg tgaccacctg gcgaatctca
1081 gctggaagtg gtggtcaagc agagagaacg attgcaggca ccacccgggc agtgagcaga
1141 ggagcccgga tcctgagtgc gaccacttca ggcatcttcc ttgcactgga tgtggtcaac
1201 cttgtatacg agtcaaagca cttgcatgag ggggcaaagt ctgcatctgc tgaggagctg
1261 aggcggcagg ctcaggagct ggaggagaat ctaatggagc tcactcagat ctatcagcgt
1321 ctgaatccat gccataccca ctgaccccag accagtgcag ccagcagggg aggtgagcca
1381 tacacaggcc acgacaaaat gcaggcattt tattaggggg ataaagaggg caaggtaaag
1441 tttatggagc tgagtgttag tgactttggc atttctgtag ctgagcacag caggggaggg
1501 gttaatgcag atggcaagtg caccaaggag aaggcaggaa tgctggagcc tggaataagg
1561 gaggagaggg gactggagag tgtggggaat aggaagaaga aatttccttt agactaacga
1621 atatattggg gggaggaata gaggggaggt gtgcaggaac cagcaatgag aaggccagga
1681 aaagaaagag ctgaaaatgc agaaagccga agagttagaa cttttggata cagcagaaga
1741 aacagcggct ccactaccga cctgcccccg gttcgatgtc cttccaagaa tgaagtcttt
1801 ccctggtgat ggtcccctgc cctgtctttc cagcatccac tctgtcttgt cctcctggaa
1861 gtgtatctca gtcagccagt ggcttcttga tgatggcggt ggaggtggtg gttgtagtgt
1921 gatggatccc ctttaggtta tttaggggta tatgtcccct gcttgaaccc tgaaggccag
1981 gtaatgagcc atggccattg tccccagctg aggaccaggt gtctctaaaa acccaaacat
2041 cctggagagt atgcgagaac ctaccaagaa aaacagtctc attactcata tacagcaggc
2101 aaagagacag aaaattaact gaaaagcagt ttagagactg ggggaggccg gatctctaga
2161 gccatcctgc tgagtgccct gtgtgtaagt cctaataaac tcacctactc accaa
ΛPOL3 cDNA sequence 5 fSEO ID NO: 35)
NM_145641 Homo sapiens apolipoprotein L, 3 (APOL3), transcript variant beta/a, mRNA
1 actctgggga aaggagggta caaccacatg taaattttat tataatgatg gtataatgaa 61 cttggggtga cctgagggca tgtttttgtg ttactgggca tgtgcccctt taggagactt 121 ccacctgtgc cttactttct ctttctttgg gatgtgctgg ccacagactt taccaaaaac 181 tccatccatt aggatggcat taggacggtt ctggggctaa acttaggtgg gccaggggct 241 gtttcactgt cagcctttct actctctttt cttacccact cctagctgct aatgtctatt 301 taactaccta atatttcccc ctttagagaa aaaaagccaa atttttgggt agatcggtga 361 caattaatct ggctacttcc tgctgacaag aggcagtggt aataattggg ttctcttttt 421 tgctctcttg tagctggtag gttgggcaga gaaaagtggt ggccatccaa ggggcccacg 481 tagatatcag acatggttga gacctcgcgg taaccttgtg tagaatcatt tggagtttta 541 tggattctag gtgggaagaa acaaaacaac cttgtaaatc aaatgagcat cgtttgaaag 601 ctataagttg tataaagctg ttttaggacc aagaaagggg gctaaccagg aaaaccagga 661 ccagttgtta aatttccacc agtcaaagcc tcctgaaact ctgttttcca ttaacttgtt 721 ggccctgtct gtaatttttt taagttggtt tgcactttac ctgattggtt gatgaaaaca 781 gcaatgttta tcaagtgttg cacaagctcc cccttgattg gctgtgagca aattaaaagc 841 tca caattt cataagacta tgcttgctaa tgaagcaatt tgttctgaaa gggtattgac goi ctggttagtt agattaataa tttgttgagt aatttttaag aagagtttct gggcagtaaa g61 aatggagtta aggaggtcct ccagttcccg tgccaatacc agccagaacg ccaattatag
1021 tcagtgctgt taaaactcct ctttcagttt taccagattg agcgtgtata gggaggggaa
1081 tgctatcgat aagagtgagt ttggggatga tgtaaactag ggccaaatcc ccgtttaatt
1141 agcagacaag cagagatatg ccttgtttct atacaaaaat gtgatttgtc atgttaagac
1201 aaatatcaac agtgatacta aagtagggtt tttccatgct gtgtaagtct gctttaatac
1261 cctcagaagt ggaagtcaag gctagttcat gtaatggggg aacacaggca gtacttgaca
1321 gaatgaaaga ggaatcaaaa gcccaattag aggaaggagt gatgggatcc caaccaatat
1381 tgtgaaatta tggggagctg cagttttttg caatgatttt gcccgaagtt gtgagactga
1441 aaccagaagt tgttatgttt aaaatgatat tctggtgtgg gtctggggaa aagggtagat
1501 ccagaatagc tggcttcttt ccacatagtg gttctgttgg ggggcttggg aaatgaataa
1561 aacacaaaga agaattagaa tatcaggtga aggtagcagg tgctcctggc agaagaaccc
1621 acataaggaa gtgtccagaa gccacacagg gtatatctca gagcctggag aacgtgtctg
1681 gttattatgc agatgcacgg ctggaggtgg gatccacaca gctcagaaca gctggatctt
1741 gctcacactc tttcaagaga agcttccttg aaaagaaacg ctttactgaa gaggccacca
1801 aatacttccg ggagagagtc agcccagtgc atctgcaaat cctgctgact aacaatgaag
1861 cctggaagag attcgtgact gcggctgaat tgcccaggga tgaggcagat gctctctacg
1921 aagctctgaa gaagcttaga acatatgcag ctattgagga cgaatatgtg cagcagaaag
1981 atgagcagtt tagggaatgg tttttgaaag agtttcccca agtcaagagg aagatccagg
2041 agtccataga aaagcttcgt gcccttgcaa atggtattga agaggtccac agaggctgca
2101 ccatctccaa tgtggtgtcc agctccactg gcgctgcctc tggcatcatg tcccttgctg
2161 gtcttgtttt ggcaccattt acagcaggga cgagtctggc ccttactgca gctggggtag
2221 ggctgggagc agcgtctgct gtgactggga tcaccaccag catcgtggag cactcataca
2281 catcatcagc agaagctgaa gccagcaggc tgactgcaac cagcattgac cgattgaagg
2341 tatttaagga agttatgcgt gacatcacac ccaacttact ttcccttctt aataattatt
2401 acgaagccac acaaaccatt gggagtgaaa tccgtgccat caggcaagcc agagccaggg
2461 cccgactccc tgtgaccacc tggcgaatct cagctggaag tggtggtcaa gcagagagaa
2521 cgat tgcagg caccacccgg gcagtgagca gaggagcccg gatcctgagt gcgaccactt
2581 caggcatctt ccttgcactg gatgtggtca accttgtata cgagtcaaag cacttgcatg
2641 agggggcaaa gtctgcatct gctgaggagc tgaggcggca ggctcaggag ctggaggaga
2701 atctaatgga gctcactcag atctatcagc gtctgaatcc atgccatacc cactgacccc
2761 agaccagtgc agccagcagg ggaggtgagc catacacagg ccacgacaaa atgcaggcat 2821 tttattaggg ggataaagag ggcaaggtaa agtttatgga gctgagtgtt agtgactttg 2881 gcat ttctgt agctgagcac agcaggggag gggttaatgc agatggcaag tgcaccaagg 2941 agaaggcagg aatgctggag cctggaataa gggaggagag gggactggag agtgtgggga
3001 ataggaagaa gaaatttcct ttagactaac gaatatattg gggggaggaa tagaggggag 3061 gtgtgcagga accagcaatg agaaggccag gaaaagaaag agctgaaaat gcagaaagcc 3121 gaagagttag aacttttgga tacagcagaa gaaacagcgg ctccactacc gacctgcccc 3181 cggttcgatg tccttccaag aatgaagtct ttccctggtg atggtcccct gccctgtctt 3241 tccagcatcc actctgtctt gtcctcctgg aagtgtatct cagtcagcca gtggcttctt 3301 gatgatggcg gtggaggtgg tggttgtagt gtgatggatc ccctttaggt tatttagggg 3361 tatatgtccc ctgcttgaac cctgaaggcc aggtaatgag ccatggccat tgtccccagc 3421 tgaggaccag gtgtctctaa aaacccaaac atcctggaga gtatgcgaga acctaccaag 3481 aaaaacagtc tcattactca tatacagcag gcaaagagac agaaaattaa ctgaaaagca 3541 gtttagagac tgggggaggc cggatctcta gagccatcct gctgagtgcc ctgtgtgtaa 3601 gtcctaataa actcacctac tcaccaa
APOL3 cD~NA sequence 6 (SEQ ID NO: 36)
NM_145642 Homo sapiens apolipoprotein L, 3 (APOL3), transcript variant beta/a, mRNA 1 actctgggga aaggagggta caaccacatg taaattttat tataatgatg gtataatgaa 61 cttggggtga cctgagggca tgtttttgtg ttactgggca tgtgccσctt taggagactt 121 ccacctgtgc cttactttct ctttctttgg gatgtgctgg ccacagactt taccaaaaac 181 tccatccatt aggatggcat taggacggtt ctggggctaa acttaggtgg gccaggggct 241 gtttcactgt cagcctttct actctctttt cttacccact cctagctgct aatgtctatt 301 taactaccta atatttcccc ctttagagaa aaaaagccaa atttttgggt agatcggtga 361 caattaatct ggctacttcc tgctgacaag aggcagtggt aataattggg ttctcttttt 421 tgctctcttg tagctggtag gttgggcaga gaaaagtggt ggccatccaa ggggcccacg 481 tagatatcag acatggttga gacctcgcgg taaccttgtg tagaatcatt tggagtttta 541 tggattctag gtgggaagaa acaaaacaac cttgtaaatc aaatgagcat cgtttgaaag 601 ctataagttg tataaagctg ttttaggacc aagaaagggg gctaaccagg aaaaccagga 661 ccagttgtta aatttccacc agtcaaagcc tcctgaaact ctgttttcca t aacttgtt 721 ggccctgtct gtaatttttt taagttggtt tgcactttac ctgattggtt gatgaaaaca 781 gcaatgttta tcaagtgttg cacaagctcc cccttgattg gctgtgagca aattaaaagc 841 tcatcaattt cataagacta tgcttgctaa tgaagcaatt tgttctgaaa gggtattgac 901 ctggttagtt agattaataa tttgttgagt aatttttaag aagagtttct gggcagtaaa 961 aatggagtta aggaggtcct ccagttcccg tgccaatacc agccagaacg ccaattatag
1021 tcagtgctgt taaaactcct ctttcagttt taccagattg agcgtgtata gggaggggaa
1081 tgctatcgat aagagtgagt ttggggatga tgtaaactag ggccaaatcc ccgtttaatt
1141 agcagacaag cagagatatg ccttgtttct atacaaaaat gtgatttgtc atgttaagac
1201 aaatatcaac agtgatacta aagtagggtt tttccatgct gtgtaagtct gc ttaatac
1261 cctcagaagt ggaagtcaag gctagttcat gtaatggggg aacacaggca g acttgaca
1321 gaatgaaaga ggaatcaaaa gcccaattag aggaaggagt gatgggatcc caaccaatat
1381 tgtgaaatta tggggagctg cagttttttg caatgatttt gcccgaagtt gtgagactga
1441 aaccagaagt tgttatgttt aaaatgatat tctggtgtgg gtctggggaa aagggtagat
1501 ccagaatagc tggcttcttt ccacatagtg gttctgttgg ggggcttggg aaatgaataa
1561 aacacaaaga agaattagaa tatcagggta tatctcagag cctggagaac gtgtctggtt
1621 attatgcaga tgcacggctg gaggtgggat ccacacagct cagaacagct ggatcttgct
1681 cacactcttt caagagaagc ttccttgaaa agaaacgctt tactgaagag gccaccaaat
1741 acttccggga gagagtcagc ccagtgcatc tgcaaatcct gctgactaac aatgaagcct
1801 ggaagagatt cgtgactgcg gctgaattgc ccagggatga ggcagatgct c ctacgaag
1861 ctctgaagaa gcttagaaca tatgcagcta ttgaggacga atatgtgcag cagaaagatg
1921 agcagtttag ggaatggttt ttgaaagagt ttccccaagt caagaggaag atccaggagt
1981 ccatagaaaa gcttcgtgcc cttgcaaatg gtattgaaga ggtccacaga ggctgcacca
2041 tctccaatgt ggtgtccagc tccactggcg ctgcctctgg catcatgtcc ct tgctggtc
2101 ttgttttggc accatttaca gcagggacga gtctggccct tactgcagct ggggtagggc
2161 tgggagcagc gtctgctgtg actgggatca ccaccagcat cgtggagcac tcatacacat
2221 catcagcaga agctgaagcc agcaggctga ctgcaaccag cattgaccga ttgaaggtat
2281 ttaaggaagt tatgcgtgac atcacaccca acttactttc ccttcttaat aattattacg
2341 aagccacaca aaccattggg agtgaaatcc gtgccatcag gcaagccaga gccagggccc
2401 gactccctgt gaccacctgg cgaatctcag ctggaagtgg tggtcaagca gagagaacga
2461 ttgcaggcac cacccgggca gtgagcagag gagcccggat cctgagtgcg accacttcag
2521 gcatcttcct tgcactggat gtggtcaacc ttgtatacga gtcaaagcac ttgcatgagg
2581 gggcaaagtc tgcatctgct gaggagctga ggcggcaggc tcaggagctg gaggagaatc
2641 taatggagct cactcagatc tatcagcgtc tgaatccatg ccatacccac tgaccccaga
2701 ccagtgcagc cagcagggga ggtgagccat acacaggcca cgacaaaatg caggcatttt
2761 attaggggga taaagagggc aaggtaaagt ttatggagct gagtgttagt gactttggca
2821 tttctgtagc tgagcacagc aggggagggg ttaatgcaga tggcaagtgc accaaggaga
2881 aggcaggaat gctggagcct ggaataaggg aggagagggg actggagagt gtggggaata
2941 ggaagaagaa atttccttta gactaacgaa tatattgggg ggaggaatag aggggaggtg
3001 tgcaggaacc agcaatgaga aggccaggaa aagaaagagc tgaaaatgca gaaagccgaa
3061 gagttagaac ttttggatac agcagaagaa acagcggctc cactaccgac ctgcccccgg
3121 ttcgatgtcc ttccaagaat gaagtctttc cctggtgatg gtcccctgcc ctgtctttcc
3181 agcatccact ctgtcttgtc ctcctggaag tgtatctcag tcagccagtg gcttcttgat
3241 gatggcggtg gaggtggtgg ttgtagtgtg atggatcccc tttaggttat ttaggggtat
3301 atgtcccctg cttgaaccct gaaggccagg taatgagcca tggccattgt ccccagctga
3361 ggaccaggtg tctctaaaaa cccaaacatc ctggagagta tgcgagaacc taccaagaaa
3421 aacagtctca ttactcatat acagcaggca aagagacaga aaattaactg aaaagcagtt
3481 tagagactgg gggaggccgg atctctagag ccatcctgct gagtgccctg tg gtaagtc
3541 ctaataaact cacctactca ccaa
[0347] Following are amino acid sequences PADI2 (SEQ ID NO: 37), APOB (SEQ ID NO: 38), IL1RL2 (SEQ ID NIO: 39), ILIRLI (SEQ ID NO: 40-42), WASPIP (SEQ ID NO: 20), ADAMTS2 (SEQ ID NO: 43-44), BVΕS (SEQ ID NO: 23-24), TM7SF3 (SEQ ID NO: 25), PELI2 (SEQ ID NO: 26), LOXLl (SEQ ID NO: 27), CASPR4 (aka CNTNAP4) (SEQ ID NO: 28-29), GPR50 (SEQ ID NO: 30), and APOL3 (SEQ ID NO: 31-36)..
PADI2 amino acid sequence (SEQ ID NO: 37)
NP_031391 peptidyl arginine deiminase, type II; protein arginine deiminase [Homo sapiens]
MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWNEVVRDGEAEEVA
TΝGKQRWLLSPSTTLRVTMSQASTEASSDKVTVΝYYDEEGSIPIDQAGLFLTAIEISLDVDADRD
GVVEKΝΝPKKASWTWGPEGQGAILLVΝCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTK
GPDRLPAGYEΓVLYISMSDSDKVGVFYVEΝPFFGQRYΓHILGRRKLYHVVKYTGGSAELLFFVEG
LCFPDEGFSGLVSIHVSLLEYMAQDΓPLTPIFTDTVIFRIAPWIMTPΝILPPVSVFVCCMKDΝYLFL
KEVKΝLVEKTΝCELKVCFQYLΝRGDRWIQDEΓEFGYΓEAPHKGFPVVLDSPRDGΝLKDFPVKEL
LGPDFGYVTREPLFESVTSLDSFGΝLEVSPPVTVΝGKTYPLGRΓLIGSSFPLSGGRRMTKVVRDFL
KAQQVQAPVELVSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIM
FKGLGGMSSKWTΓI^KILSΝESLVQEΝLYFQRCLDWΝRDILKKELGLTEQDIIDLPALFKMDEDH
RARAFFPΝMVΝMΓVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGE
VHCGTΝVRRKPFTFKWLHMVP
APOB amino acid sequence (SEQ ID NO: 38)
NP_000375 apolipoprotein B precursor; apoB-100; apoB-48 [Homo sapiens]
MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRI YTYNYEAESSSGV
PGTADSRSATRΓ TCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRY
ELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLFLDTWGNCSTHFTVKTRK
GNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKE
QHLFLPFSYNNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTI STSPPKQAEAVLK
TLQELKKLTISEQ QRANLFNKLVTELRGLSDEAVTSLLPQLFFIVSSPITLQALVQCGQPQCSTHI
LQWLKRVHANPLLIDVVTYLVALIPEPSAQQLIIEIFNMARDQRSRATLYALSFIAVNNYHKTNPT
GTQELLDIANYL EQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMI
QKAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADΓNKΓVQILPWEQN
EQVKNFVASHLA.NILNSEELDIQDLKKLVKEALKESQLPTVMDFRKFSRNYQLYKSVSLPSLDPA
SAKIEGNLIFDP NYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLEALFGKQGFFPDSVNK
ALYWVNGQVPDGVSKVLVDHFGYTKDDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRI
LGEELGFASLHDLQLLGKLLLMGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPTGAGL
QLQISSSGVIAPGAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQMNTNFFHES
GLEAHVALKAGF LKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLRENRQS*WSVCKQVFPGLNY
CTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAE
GAKQTEATMTFI YNRQSMTLSSEVQIPDFDVDLGTILRVNDESTEGKTSYRXTLDIQNKKITEVA
LMGHLSCDTKEERKIKGVISIPRLQAEARSEILAHWSPAKLLLQMDSSATANGSTVSKRVAWHY
DEEKTEFEWNTGTL^VDTKKMTSNFPVDLSDYPKSLIAMYANRLLDHRVPETDMTFPVHVGSKLRV
AMSSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRRVKYTLNKNSLKI
EIPLPFGGKSSRD-LKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPKLYQLQYPLLGVLDLSTNV
YSNLYNWSASYSGGNTSTDITFSLP^RYIIMKADSVVDLLSYNVQGSGETTVDHKNTFTLSCDGS
LRHKFLDSNIKFSITVEKLGNNPVSKGLL1FDASSSWGPQMSASVHLDSKKXQHLFVKEVKIDGQ
FRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQSGII
KNTASLKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSL
NSHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLENELNAELGLSGASMKL
TTNGRFREHNAI FSLDGKAALTELSLGSAYQAMILGVDSKNIFNFKVSQEGLKLSNDMMGSYA
EMKFDHTNSLNLAGLSLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSDLKYNALDLTNN GKLRLEPLKLI1VAGNLKGAYQN-SIEIKHIYAISSAALSASYKADTVAKVQGVEFSH] -,NTDIAGL
ASAROMST-NYNSDSLHESNVFRSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPL
AFTFSHDYKGSTSHHLVSRKSISA-ALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDAYNTK
DKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFVKYDKNQDVHSI
NLPFFETLQEYFERNRQTIRVVVE ^QRNLKHINIDQFVRKYRAALGKLPQQANDYL^SFNWER
QVSIXAKEKLTALTKXYMTENDIQIALDDAKΓNFNEKLSQLQTYMIQFDQYIKDSYDLFIDLKIAIA
NIMEIIEKLKSLDEITYFFLRV-^NKLTIFΩLHLFIENIDFNKSGSSTASWIQNVDTKYQIRJQIQEKLQ
QLKRFFLQNIDIQHLAGKLKQHFFIAIDVRVLLDQLGTTISFERTNDVLEHVKHFVINLIGDFEVAEKI
NAFRAKVHELIERYEVDQQIQVL DKLVELTHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFID
DAVKKLNELSFKTFFFIDVNKFLD LIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKA
EALKLFLEETKATVAVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMD
IQQELQRYLSLVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEI
KTILGTMPAFEVSLQALQKATFQTPDFTVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILNTFHIP
SFTIDFVEMKVKIIRTROQMQNSELQWPVPDRYLRDLKVEDIPLARITLPDFRLPEIAIPEFIIPTLNL
NDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADIGNGTTSANEAGIAASITAK
GESKLEVLNFDFQANAQLSNPKΓ ΠPLALKESVKFSSKYLRTEHGSEMLFFGNAIEGKSNTVASLH
TEKNTLELSNGVRV-KINNQLTLDSL^TKYFHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGK
GSWKWACPRFSDEGTHESQISFTLΈGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQV
DSQHVGHSVLTAKGMALFGEGK^EFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNL
KVRFPLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGΓNGE
ANLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKFIRHSIT
NPLAVLCEFISQSIKSFDROTEKNΓ NNALDFVTKSYNETKIKFDKYKAEKSHDELPRΓFQIPGYTV
PVVNVEVSPFTIEMSAFGYVFPK^^VSMPSFSILGSDVRVPSYTLILPSLELPVLFFVPRNILKLSLPHF
KELCTISFFLFIPAMGNITYDFSFKSSVITLNTNAELFNQSDRVAHLLSSSSSVIDALQYK-LEGTTRLT
RKRGLKXATALSLSNKFVEGSHNSTVSLTTKNMEVSVAKTTKAEIPILRMNFKQELNΓGNTKSKP
TVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEAN
TYLNSKSTRSSVKLQGTSKIDDIWT^LEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEH
TSKATLELSPWQMSALVQVHASQPSSFI DFPDLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQ
VELSNDQEKAHLDIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTK
NPNGYSFSIPVKVLADKFITPGLKLNDLNSVLVMPTFHVPFTDLQVPSCKLDFREIQIYKKLRTSS
FALNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAAL.DLNAVAN
KIADFELPTIRVPEQTIEIPSIKFSVPAGRVTPSFQALTARFEVDSPVYNATWSASLKNKA-DWETVL
DSTCSSTVQFLEYELNVLGTHKEΓJGTLASKTKGTLAHI^FSAEYEEDGKFEGLQEVVEGKAHLN
IKSPAFTDLHLRYQKDKKGISTSAASPAVGTVGMDMDEDDDFSKWNFYYSPQSSPDKKLTIFKT
ELRVRESDEETQΓKVNWEEEAASGLLTSLKDNVPKATGVLYDYVNKYHWEHTGLTLREVSSKL
RRNLQNNAEWVYQGAIRQIDDIDΎRFQKAASGTTGTYQEWKDKAQNLYQELLTQEGQASFQG
LKDNVFDGLVRVTQKFHMKVKHXIDSLIDFLNFPRFQFPGKPGIYTREELCTMFIREVGTVLSQV
YSKVIWGSEILFSYFQDLVITLPFELRKHKLIDVISMYRELLKDLSKEAQEVFKAIQSL.KTTEVLR
NLQDLLQFIFQLΓEDNIKQLKEM FTYLINYIQDEINTIFNDYIPYVFKLLKENLCLNLΓ^KFNEFIQ
NELQEASQELQQIHQYIMALREEVFDPSRVGWTVKYYELEEKTVSLIKNLLVALKDFHSEYRVSAS
NFTSQLSSQVEQFLHRNTQEYLSIL.TDPDGKGKEKIAELSATAQEΠKSQAIATKKΠSD"YHQQFRY
KLQDFSDQLSDYYEKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELTIIL
IL1RL2 amino acid sequence (SEQ ID NO: 39)
NP_003845 interleukin 1 receptor-like 2 precursor; interleukin-1 receptor-related protein 2 [Homo sapiens]
MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYK-NSSKIPVS KIIQSWHQDETWILFLPMEWGDSGVYQCVIKGRDSCHWHVNLTVFEKHWCDTSIGGLPNLSDE YKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAE-DRGNYAC QAILTHSGKQYEVLNGITVSITERAGYGGSVPKIΓYPKNHSIEVQLGTTLIVDCNVTDΓKDNTNLR CWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGNSTAY πLQLPAPDFRAYLIGGLIALVAVA.VSVVYrYΝIFKIDIVLWYRSAFHSTETTVDGKLYDANNLYPK PHKESQRHAVDALVLMLPEVLERQCGYKLFIFGRDEFPGQAVAΝVroEΝVKLCRRLINrVVPESL GFGLLKΝLSEEQIAVYSALIQDG-v KVILIELEKiEDYTVMPESIQYIKQKHGAIRWHGDFrEQSQC MKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPCYRTAGPELGSRRKKCTLTTG
ILIRLI amino acid sequence 1 (SEQ ID NO: 40)
ΝP_057316 interleukin 1 receptor-like 1 isoform 1 precursor; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed gene ; ST2 protein [Homo sapiens]
MGFWΓLAILTILMYSTAAKFSKQS GLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNR
VFASGQLLKFLPAAVADSGIYTCRNRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNS
KIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAFΓKSFLVIDNVMTEDAGDYTCKFIHNENIGANY
SVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTK
ITDFGEPWQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRK
NPROHHSIYCIIAVCSVFLMLLNVLNIILKMFWFFIATLLWRDIAKPYKTRNDGKLYDAYVVYPRN
YKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQI
THNKEFAYEQEVALHCALIQNDA VILIEMEALSELDMLQAEALQDSLQHLMKVQGTI WRED
HIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ
ILIRLI amino acid sequence 2 (SEQ ID NO: 41)
NP_003847 interleukin 1 receptor-like 1 isoform 2 precursor; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed gene ; ST2 protein [Homo sapiens]
MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTNDWYYSQTNKSIPT
QEP^RNFASGQLLKFLPAAVA_DSGIYTCINRSPTFNRTGYANNTIYKKQSDCNNPDYLM
YSTVSGSEKΝSKIYCPTIDLYΝWTAPLEWFKΝCQALQGSRYPVAH SFLVIDΝVMTEDA
GDYTCKFIHΝEΝGAΝYSVTAT*RSFTNKDEQGFSLFPNIGAPAQΝEIKENEIGKΝA]ΝT.TCS
ACFGKGTQFLAAVL QLNGT ITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADNKE
EDLLLQYDCLALΝLHGLRRHrNRLSRKΝPSKECF
ILIRLI amino acid sequence 3 (SEQ PD ΝO: 42)
ΝP_775661 interleukin 1 receptor-like 1 isoform 3 precursor; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed gene ; ST2 protein [Homo sapiens] MGFWLLAILTILMYSTAAKFSKQSWGLENEAVLIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNR. VFASGQLLKFLPAAVADSGIYTCΓVRSPTFN TGYANVTΓYKKQSDCNVPDYLMYSTVSGSEKNS KIYCPTIDLYNWTAPLEWFKNCQALQGSRYF FIKSFLVIDNVMTEDAGDYTCKFIHNENGANN SVTATRSFTVKVWCQSFCKLKKSLIFSNTHVV^IQSLMRGFVMVYYGVHKCCRVVFNLCLQYFQH
HQWP
WASPIP amino acid sequence (SEQ ID NO: 43) NP_003378 WASP-interacting protein [Homo sapiens]
MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGA
GAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPP
LLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQ
SSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDK
PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETP
RLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQL
PSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYV
QTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR
ADAMTS2 amino acid sequence 1 CSEO ID NO: 44)
NP_055059 a disintegrin and metalloprotease with thrombospondin motifs-2 isoform 1; procollagen I N-proteinase; Procollagen N-endopeptidase [Homo sapiens]
MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTD
AQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNNTVFGRDLHLRLRPNAR
LVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEP
LEKGLAAQEAEQGRVFTVVYTRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRA
RRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNTv^EIYHDESLGAHINVVLVRIILL
SYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTG
MCHPVRSCTLNHEDGFSSAFVVAFffiTGFfVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFITRF
HWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTF
DPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGS
CSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFE
HGDAQP WLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCR
VGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATS
FfHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVα
DTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLD
HKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDN
TTRSVHAKHCNDARPESRRACSRELCPGRW- AGPWSQCSVTCGNGTQERPVPCRTADDSFGIC
QEERPETARTCRLGPCPRNISDPSKKSYVVQ LSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLS
YCSIPGYNKLSCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPL
NASSTNATEDHPETNAVDEPYKTHGLEDEVQPPNLIPRRPSPYEKTRNQRIQELIDEMRKKEMLG
KF ADAMTS2 amino acid sequence 2 (SEQ ID NO: 45)
NP_067610 a disintegrin and metalloprotease with thrombospondin motifs-2 isoform 2; procollagen I N-proteinase; Procollagen N-endopeptidase [Homo sapiens]
MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPA-NARLAAAADPPGGPLGHGAERILAVPVRTD
AQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNAR
LVAPGATMEWQGEKGTTRVEPLLGSCLYVGDV GLAEASSVALSNCDGLAGLIRMEEEEFFIEP
LEKGLAAQEAEQGRVHWYRRPPTSPPLGGPQAI.DTGASLDSLDSLSRALGVLEEHANSSRRRA
RRHAADDDYNffiVLLGVDDSVVQFHGKEHVQKΥLLTLMNIVNEIYlTDESLGAHrNVVLVMILL
SYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTG
MCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVl^GSIMAPLVQAAFHRF
HWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTF
DPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKFRPGAVAHACYPSTLGGQGRWIA
BVES amino acid sequence (SEQ ID NO: 46)
NP_009004 blood vessel epicardial substance; popeye protein 1; popeye domain containing 1 [Homo sapiens]
MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCEN"WREIHHLVFHVANICFAVGLVIPTTLHLHMIF
LRGMLTLGCTLYTVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKIEKELSGMYRRLF
EPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPC
AFroSPEFRSTQMHKGEKFQVTIlADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYS
LNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSSDSDDGLHQFLRGTSSMSSLHVSSPHQRA
SAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP
TMS7SF3 amino acid sequence (SEQ ID NO: 47)
NP_057635 transmembrane 7 superfamily member 3; seven transmembrane protein TM7SF3 [Homo sapiens]
MGFLQLLVVAVLASEHRVAGAAEVFGNSSEGLIEFSVGKFRYFELNRPFPEEAILHDISSNVTFLI
FQIHSQYQNTTVSFSPTLLSNSSETGTASGLVFILRPEQSTCTWYLGTSGIQPVQNMAILLSYSERD
PVPGGCNLEFDLDROPNRYLEYNFFETTIKFAPANLGYARGVDPPPCDAGTDQDSRWRLQYDVY
QYFLPENDLTEEMLLKHLQRMVSVPQVKASALI VVTLTANDKTSVSFSSLPGQGVIYNVIVWDP
FLNTSAAYIPAHTYACSFEAGEGSCASLGRVSSKVFFTLFALLGFFICFFGHRFWKTELFFIGFIIM
GFFFYILITRLTPΓKYDVNLILTAVTGSVGGMFLVAVWWRFGILSICMLCVGLVLGFLISSVTFFTP
LGNLKIFHDDGVFWVTFSCIAILIPVVFMGCLRILT^ILTCGVIGSYSVVLAIDSYWSTSLSYITLNV
LKRALNKDFHRAFTNVPFQTNDFIILAVWGMLAVSGITLQIRRERGRPFFPPHPYKLWKQERERR
VTNILDPSYHIPPLRERLYGRLTQIKGLFQKEQPAGERTPLLL
PELI2 amino acid sequence (SEQ ID NO: 48) NP_067078 pellino 2 [Homo sapiens]
MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNTGDRGRRKSRFALYKRPKANGVKPSTVHVIS TPQASKAISCKGQHSISYTLSRNQTVVVEYTHDK-DTDMFQVGRSTESPIDFVVTDTISGSQNTDE AQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSP NIFLGEKAAKWKNPDGHMDGLTTNGVLV MHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWR TADGLFHTPTQKIilEALRQErNAARPQCPVGLNrPAFPSiNliKEVVEEKQPWAYLSCGHVHGYH NWGHRSDTEANERECPMCRTVGPYVPLWLGCE GFYVDAGPPTHAFTPCGHVCSEKSAKYWS QIPLPHGTHAFHAACPFCATQLVGEQNCrKLIFQGPID
LOXLl amino acid sequence (SEQ ID NO: 49) NP_005567 lysyl oxidase-like 1 [Homo sapiens]
MALARGSRQLGALVWGACLCVLVHGQQAQPGQGSDPARWRQLIQWENNGQVYSLLNSGSEY
VPAGPQRSESSSRVLLAGAPQAQQRRSHGSPRRRQAPSLPLPGRVGSDTVRGQARHPFGFGQVP
DNWREVAVGDSTGMALARTSVSQQRHGGSASS^VSASAFASTYRQQPSYPQQFPYPQAPFVSQY
ENYDPASRTYDQGFVYYRPAGGGVGAGAAAVASAGVΓYPYQPRARYEEYGGGEELPEYPPQGF
YPAPERPYVPPPPPPPDGLDRRYSHSLYSEGTPGFEQAYPDPGPEAAQAHGGDPRLGWYPPYAN
PPPEAYGPPRALEPPYLPVRSSDTPPPGGERNGAQQGRLSVGSVYRPNQNGRGLPDLVPDPNYV
QASTYVQRAHLYSLRCAAEEKCLASTAYAPEATEYDVRVLLRFPQRVKNQGTADFLPNRPRHT
WEWHSCHQHYHSMDEFSFTΛ-LLDAATGKKVAEGI1KASFCLEDSTCDFGNLKRYACTSHTQGL
SPGCYDTYNAD-DCQWIDITDVQPGNYILKVFΓVNΓPK^^
CKΓVQS
CASPR3 amino acid sequence 1 (SEQ ID NO: 50)
NP_207837 cell recognition protein CASPR4 isoform 1; contactin associated protein-like 4 [Homo sapiens].
MLLFYLLVVLSIDSTKASALTNPNVALFLLADDCΓJDPLVSALPQASFSSSSELSSSHGPGFARLNR
RDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYLLMFSDSGWNWKQYR
QEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSEVVDLDGK
SSLLYRFDQKSLSPIKDΠSLKFKTMQSDGILLF-I^EGPNGDFFLTLQLRRARLFLLINSGEAKLPSTST
LVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDE-TI HFHARGEFNLMNLDYEISFGGIPAPGKS
VSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLALPDFS
GEEEVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQ
WHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQΓYSGGTYYFGGCPDKSFGSKCKSPLGGFQGC
MRLISISGKWDLISVQQGSLGNFSDLQIDSCGISORCLPNYCEHGGECSQSWSTFHCNCTNTGYR
GATCHNSIYEQSCEAYKHRGNTSGFYYIDSDGSGPLEPFLLYCNMTETAWTIIQHNGSDLTRVRN
TNPENPYAGFFEYVASMEQLQATINRAEHCEQEFTYYCKKSRLVNKQDGTPLSWWVGRTNETQ
TYWGGSSPDLQKCTCGLEGNCROSQYYCNCDADPXNEWTNDTGLLAYKEHLPVTKTVITDTGRL
HSEAAYKLGPLLCRGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA
DFLRIELRSPTVVTFSFDVGNGPFEISVQSPTITFND- QWFIHVRVERNMKEASLQVDQLTPKTQPA
PADGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQI-NGMTLDLEERAQVTPEVQPGCRGHCSSYG
KLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFH
GDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLS"VIIAKNGSLQIRYKLNKYQEPDVVNFDFKN
MADGQLFTH lNPxEEGVVFffilDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQETALAGAQ
GFTGCLSAVQLSHVAPLKAALHPSHPDPVTVTGFTVTESSCMAQPGTDATSRERTHSFADHSGTI
DDrøPLANAIKSDSAVIGGLIAVVIFILLCITAIAVRJYQQKRLYKRSEAKRSENVDSAEAVLKSEL
NIQNAVNENQKEYFF
CASPR3 amino acid sequence 2 fSEO ID NO: 51)
NP_620481 cell recognition protein CASPR4 isoform 2; contactin associated protein-like 4 [Homo sapiens] MWNYDCDDPLVSALPQASFSSSSELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQIDLGER
MEVTAVATQGGYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWGFSGNANADSVVYYRLQPSI
KARFLRPlPLEWNPKGMGMRffiVFGCAYRSEVVDLDGKSSLEYRPDQKSLSPIKDIISLKFKTMQ
SDGILLHREGPNGDHITLQLRRARLFLLiNSGEAKLPSTSTLNNrLTLGSLLDDQHWHSVLIQRLGK
QVNFTVDEHRHHFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLA
KQQKPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSEL
QLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASA
APLLGPEQrcSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFSDL
QmSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSrYEQSCEAYKHRGNTSGF
YYIDSDGSGPLEPFLLYCNMTETAWTIIQHNGSDLTRVRNTNPENPYAGFFEYVASMEQLQATIN
RAEHCEQEFTYYCKKSRLVNKQDGTPLSWWVGRTNETQTYWGGSSPDLQKCTCGLEGNCIDSQ
YYCNCDADRNEW
GPR50 amino acid sequence 2 (SEQ ID NO: 52) NP_004215 G protein-coupled receptor 50 [Homo sapiens].
MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITΓVVDLIGNSMVΓLAVTKNKKLRNSGNIF
VVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFRTGLSVVGSIFNRVAIAINRYCYIC
HSLQYERIPSVRNTCRYLVITW TVLAVLPNMYIGTIEYDPRTYTCLFNYLNNPVFTVTIVCIHFV
LPLLRVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPLNVLTVLVAV
SPKEMAGIΠPNWLYLAAYFIAYFNSCLNAVΓYGLLNENFRREΎWTIFHAMRHPΠFFPGLISDIRE
MQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHS
RSSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGITPXSATVYPKPASVHFKGDSVHFK
GDSVHFKPDSVHFKPASSNPKPITGHHYSAGSHSKSAFSAATSHPKPIKPATSHAEPTTADYPKPA
TTSHPKPAAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPA-AGPTKPAASQLESDTIADLPDPT
WTTSTNDYHDVVVVDVEDDPDEMAV
APOL3 amino acid sequence 2 (SEQ ID NO: 53)
NP_663615 Homo sapiens apolipoprotein L, 3 (APOL3), isoform 1, protein
MGLGQGWGWEASCFACLTRSCCQVVTFTFPFGFQGISQSLENJVSGYYADARLEVGSTQLRTAGS
CSHSFKRSFLEKKRFTEEATKYFRERVSPVHLQILLTNNEAW-E RFVTAAELPRDEADALYEALK
KLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKPJ IQESIEKLPALANGIEEVHRGCTISNVVSSST
GAASGFMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSI
DRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARA-RARLPVTTWRISAGSGGQAERTI
AGTTRAVSRGARILSATTSGΓFLALDVVNLVYESKHLHEGAI SASAEELRRQAQELEENLMELT
QIYQRLNPCHTH
APOL3 amino acid sequence 2 (SEQ ID NO: 54)
NP_055164 Homo sapiens apolipoprotein L, 3 (APOL3), isoform 2, protein
MDSEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYA AIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGRLEEVHRGCTISNVVSSSTGAASGI MSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTS1NEFISYTSSAEAEASRLTATSIDRLKVF KEVMRDITPΝLLSLLΝΝYYEATQTIGSEIRAIRQARARARLPNTTWRISAGSGGQAERTIAGTTRA VSRGARILSATTSGIFLALDVVΝLVYESKHLHEGAKSASAEBLRRQAQELEEΝLMELTQΓYQRLΝ
PCHTH
APOL3 amino acid sequence 2 (SEQ ID NO: 55)
NP_663616 Homo sapiens apolipoprotein L, 3 (APOL3), isoform 3, protein
MSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSΓVEHSYTSSAEAEASRLTATSIDRLKVF KEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPNTTWRISAGSGGQAERTIAGTTRA VSRGARILSATTSGIFLALDVVΝLVYESKΗLHEGAKSASAEBLRRQAQELEEΝLMELTQIYQRLΝ
PCHTH [0348] Modifications may be made to the foregoing without departing from the basic aspects of the invention. Although the invention has been described in substantial detail with reference to one or more specific embodiments, those of skill in the art will recognize that c-hanges may be made to the embodiments specifically disclosed in this application, yet these modifications and improvements are within the scope and spirit of the invention, as set forth in the aspects which follow. All publications or patent documents cited in this specification are incorporated herein by reference as if each such publication or document was specifically and individually indicated to be incorporated herein by reference. [0349] Citation of the above publications or documents is not intended as an admission that any of the foregoing is pertinent prior art, nor does it constitute any admission as to the contents or date of these publications or documents. U.S. patents and other publications referenced herein are hereby incorporated by reference.

Claims

What is claimed is: 1. A method for identifying a subject at risk of osteoarthritis, which comprises detecting the presence or absence of one or more polymorphic variations associated with osteoarthritis in a nucleic acid sample from a subject, wherein the one or more polymorphic variations are detected in a nucleotide sequence in SEQ ID NO: 1-13, or referenced in Table B, or a substantially identical sequence thereof, or a fragment of the foregoing; whereby the presence of the polymorphic variation is indicative of the subject being at risk of osteoarthritis.
2. The method of claim 1, which further comprises obtaining the nucleic acid sample from the subject.
3. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 21233000 to 21243000 of chromosome 2 in human genomic DNA.
4. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 2 selected from the group consisting of 238, 294, 295, 347, 1425, 4891, 5087, 7041, 7121, 7219, 7443, 7485, 10939, 11367, 11571, 11839, 12551, 12646, 13469, 14913, 15205, 15246, 15695, 17473, 17610, 17828, 18130, 18281, 18623, 18890, 21561, 23 100, 23872, 24581, 24582, 24983, 27540, 30846, 31415, 31453, 31899, 37000, 38681, 39287, 42951, 45648, 46222, 46687, 47020, 47593, 48513, 49723, 49986, 53018, 53296, 53547, 53899, 53916, 53933, 54305, 55327, 55895, 56143, 56640, 58486, 59576, 63048, 64008, 64018, 64859, 65995, 66905, 67183, 67942, 68101, 68521, 68664, 68988, 69178, 72143, 74183, 74312, 74407, 75518, 76153, 77398, 77615, 79-092, 80000, 80125, 80595, 81061, 81151, 81918, 83072, 83137, 83235, 83263, 83279, 83280, 83533, 86856, 87186, 87189, 87727, 87978, 89129, 89556, 89702, 90233, 93060, 94779, 95367, 95844, 95942, 96884 , 96938, 97627, 97777, 97871, 98746 and 99663.
5. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 2 selected from the group consisting of 721 9, 7485, 11839, 31899, 37000, 48513, 49986, 56640, 74407, 77398, 93060 and 97627.
6. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 102456500 to 102471500 of chromosome 2 in human genomic DNA.
7. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 3 selected from the group consisting of 225, 509, 860, 874, 939, 1483, 1798, 2189, 2215, 2282, 2340, 2963, 3369, 3481, 3564, 3653, 4860, 4941, 4975, 5321, 5346, 5541, 5633 6007, 6317, 6378, 6382, 6426, 6479, 6641, 6703, 6705, 7963, 8525, 8526, 8598, 8624, 8883, 8980, 13578, 16135, 16141, 16642, 16931, 17004, 17009, 17010, 18713, 18853, 20783, 21335, 22180, 22268; 22285, 25378, 25906, 26015, 26475, 26798, 27042, 27649, 27827, 27873, 28122, 28202, 28232, 28240 29546, 29748, 30054, 30646, 31149, 36912, 36936, 37184, 39064, 39343, 40868, 40917., 41113, 47343 47806, 47911, 48009, 48621, 49245, 49247, 49299, 49302, 49514, 49626, 49791, 50010, 50294, 51482 51556, 51855, 51956 ,52155, 52448, 52458, 52511, 52607, 54049, 54224, 54567, 55052, 55857, 55941 56120, 56349, 56727, 57232, 58806, 61181, 63808, 64526, 64865, 64928, 64966, 65080, 65690, 66228 66982, 72511, 74170, 74264, 74333, 74502, 74741, 75321, 82558, 85366, 85469, 86485, 87687, 89463 89660, 95718 and 95821.
8. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 3 selected from the group consisting of 2215, 3369, S 642, 20783, 52155, 55052, 55941, 74333, 74741, 85366, 85469, 87687, 89660 and 95718.
9. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 102570000 to 102583000 of chromosome 2 in -human genomic DNA.
10. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 4 selected from the group consisting of 207, 6019, 641 4, 7341, 10984, 12351, 13335, 16584, 16737, 23897, 24057, 25145, 25300, 26262, 26312, 26589, 27302, 27358, 27451, 27552, 30731, 32085, 32139, 33184, 42382, 42569, 44823, 45217, 45548, 45601, 45722, 45967 ,47367, 47642, 48126, 49218, 49274, 49433, 49610, 51282, 51466, 53757, 53960, 54031, 54574-, 55679, 56100, 56182, 59817, 60533, 60656, 72209, 72778, 74293, 77335, 78029, 78374, 78421, 78434-, 79174, 79397, 79562, 79700, 79730, 79904, 79920, 79938, 79972, 80125, 80368, 83484, 85536, 85829», 86425, 88083, 88770, 90622, 90924, 91634, 92029, 95152, 95348, 96145, 96793, 97015, 97064, 97711 , 97855 and 98708.
11. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 4 selected from the group consisting of 6414, 51282, 54574, 78374, 92029 and 96793.
12. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions positions 175647734 to 175655734 of chromosome 2 in human genomic DNA.
13. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 5 selected from the group consisting of 209, 5908, 7460), 7733, 7855, 7904, 8869, 9480, 13820, 15152, 17713, 17804, 18220, 19083, 19123, 19605, 20247, 20592, 21907, 23273, 23299, 23623, 23669, 23844, 24190, 24486, 24896, 25118, 30551, 30844, 30900, 30942, 31699, 32081, 35078, 36196, 36541, 38356, 45578, 49634, 49774, 51119, 51181, 51652, 54467, 55762, 55999, 57865, 66613, 68377, 69754, 72859, 76512, 76717, 77722, 80998, 82033, 89658, 89960, 94155 and 95679.
14. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 5 selected from the group consisting of 19083, 30900, 38356, 76512 and 94155.
15. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 178746000 to 178751000 of chromosome 5 in rtuman genomic DNA.
16. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 6 selected from the group consisting of 210, 3608, 3609, 4318, 5593, 5629, 5639, 5640, 8943, 17968, 19887, 21034, 21085, , 21596, 23379, 23432, 24007, 261- 21, 26273, 26755, 27411, 27710, 27842, 28379, 29603, 31232, 31504, 32583, 32794, 32840, 33044, 33150, 33218, 33513, 33959, 34486, 36289, 36570, 38247, 38477, 38518, 38529, 38667, 39781, 39856, 39927, 40506, 41869, 42452, 44788, 46059, 46846, 47712, 48796, 49441, 49602, 49723, 50050, 50171, 50477, 50818, 50833, 50881, 50882, 51386, 51534, 52317, 52368, 52970, 53023, 53356, 53882, 54553, 55475, 55530, 55691, 55848, 55879, 56316, 56911, 57320, 57391, 57437, 57478, 57500, 59111, 59333, 59715, 59804, 59851, 59929, 60052, 60240, 60359, 60381, 60456, 60724, 60875, 60968, 60978, 60998, 61557, 62091, 62645, 62943, 63131, 63145, 63406, 63427, 63554, 63661, 64093, 64153, 64409, 64544, 65257, 65626,65739 , 66392, 66720, 69177, 69336, 69636, 69823, 69928, 70547, 70633, 71805, 72181, 72200, 72474, 72567, 72973, 73468, 73889, 75730, 75970, 76114, 76342, 76449, 76465, 76791, 78042, 80758, 80778, 81356, 81576, 81689, 81759, 81950, 82562, 83591, 83700, 83821, 83842, 83923, 83929, 84021, 84175, 84417, 84747, 85746, 86129, 86335, 87315, 87648, 87764, 87770, 88221, 90474, 91148, 91150, 91160, 91733, 91772, 91785, 93140, 93148, 96080, 96157, 96313, 96759, 97026, 97320, 97732, 98713, 99707, 99959, 100009, 100020, 100065, 100086, 101270, 101276, 101371, 101376, 101439, 101820, 102392, 102602, 102604, 102896, 189104, 189134 and 189205.
17. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 6 selected from the group consisting of 5640, 33150, 38247, 38529, 46846, 49723, 50050, 63427, 73889, 189104 and rs42890T.
18. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 105595000 to 105615000 of chromosome 6 in human genomic- DNA.
19. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 7 selected from the group consisting of 241, 801, 899, 2091, 2290, 2440, 4959, 7914, 7969, 7972, 10831, 12399, 13841, 14461, 14680, 16808, 18231, 18394, 18505, 18684-, 19257, 20263, 20656, 21499, 21563, 21612, 21834, 22406, 22408, 22685, 23303, 23306, 25139, 25211, 25364, 25381, 25414, 25835, 26214, 27224, 27526, 27934, 28550, 29015, 29879, 29979, 30030, 30585, 31753, 31934, 33227, 33228, 35172, 36901, 36921, 36932, 37061, 37570, 38745, 38970, 39725, 40070, 40460, 41470, 41562, 41956, 42047, 42280, 42358, 42629, 43075, 43387, 43393, 43438, 44115, 44537, 45642, 46629,47496, 47515, 48329, 48862, 48908, 49038, 49080, 50204, 50404, 50426, 50531, 50840, 50964, 50971,51378, 52610, 53906, 53951, 54111, 54149, 55563, 55999, 58415, 58961, 60447, 61377, 61528, 61606, 62140, 62461, 63826, 64950, 65076, 66121, 66406, 67051, 68860, 69014, 70796, 72325, 73414, 75258, 76347, 76839, 77358, 77822, 77946, 80002, 80024, 80285, 80397, 82075, 82153, 83981, 84184, 85089, 85288, 85330, 85581, 85642, 86433, 86904, 88391, 89042, 90828, 92676, 92881, 94227, 94585, 94616, 94712, 94738, 95253, 95522, 95869 and 97856.
20. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 7 selected from the group consisting of 25414, 25835, 38970, 41470, 44115, 47496, 49038, 50204, 50840, 50964, 50971, 53906, 54149, 58415, 70796, 72325, 75258, 77822, 80002, 85288, 85581, 86904, 90828, 94616, 94712, 95869 and 97856.
21. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 27052000 to 27066000 of chromosome 12 in human genomic DNA.
22. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 8 selected from the group consisting of 230, 231, 5330, 6334, 11372, 11456, 11501, 13393, 16666, 17596, 19710, 19800, 20297, 20967, 32514, 33159, 37600, 41259, 41329, 50060, 53292, 53393, 56417, 56435, 58847, 59595, 59661, 60355, 60407, 62357, 68230, 68516, 69055, 72603, 73928, 85897 and 91554.
23. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 8 selected from the group consisting of 56435, 59595, 53292, 33159 and 41329.
24. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 71957600 to 71962600 of chromosome 15 in human genomic DNA.
25. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 10 selected from the group consisting of 213, 249, 1824, 2057, 2306, 2869, 3976, 4288, 4290, 4434, 5298, 5467, 8486, 8487, 8831, 9036, 9058, 9131, 9732, 9862, 10191, 10270, 16167, 17620, 17751, 17764, 17787, 19401, 21021, 21902, 22173, 22416, 22653, 24945, 25011, 28563, 48574, 48710, 48880, 50194, 56343, 56455, 56729, 56759, 56895, 57036, 57702, 62515, 62629, 63501, 63547, 64876, 65073, 67149, 67549, 71660, 71906 and 71911.
26. The method of claim 1, wherein a polymorphic variation is detected at position 65073 in SEQ ID NO: 10.
27. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 76221000 to 76226000 of chromosome 16 in human genomic DNA.
28. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 11 selected from the group consisting of 205, 866, 4212, 5934, 11486, 16969, 22509, 22796, 28097, 28626, 28853, 28873, 30155, 30827, 31956, 32404, 32944, 35205, 35227, 35781, 41052, 45051, 46039, 47276, 47678, 47716, 51014, 54408, 54596, 56853, 61851, 62016, 62461, 68257, 69793, 73976, 73999, 74053, 75315, 75729, 76466, 77216, 77217, 79239, 80825, 81060, 81097, 81426, 84787, 84896, 85165, 86502, 86753, 86941, 88787 and 95598.
29. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 11 selected from the group consisting of 47716 and 69793.
30. The method of claim 1, wherein the one or more polymorphic variations are detected within a region spanning chromosome positions 34828750 and 34833750 of chromosome 22 in human genomic DNA.
31. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 13 selected from the group consisting of 201, 425, 1095, 2201, 7879, 8395, 8461, 9503, 10304, 10695, 16300, 16444, 17591, 17988, 19116, 19358, 20300, 20669, 20891, 21451, 21978, 22785, 24248, 24770, 24844, 25066, 25096, 25309, 25344, 25529, 25537, 25554, 27963 28134, 28356, 29648, 29986, 30217, 30267, 30315, 30585, 30724, 30897, 30931, 31080, 31246, 31373 31463, 31467, 32188, 32288, 32520, 32594, 32657, 32677, 32764, 32784, 32830, 32872, 33121, 33348: 33952, 34184, 34361, 35026, 35192, 35600, 36033, 36289, 38869, 39629, 40530, 41621, 42379, 42802 42865, 43644, 45051, 45828, 45829, 46257, 47286, 47427, 47963, 48013, 48229, 48282, 48376, 48404 49900, 52699, 52897, 53414, 53487, 54112, 55492, 59766, 60307, 60701, 60952, 61401, 62379, 62870 62879, 63499, 64284, 64408, 64760, 65230, 66127, , 6634, 66686, 66694, 67113, 67257, 67403, 67609 68418, 68610, 69629, 70024, 70848, 71428, 71553, 71633, 71768 ,71769, 73039, 73325, 73412, 73547 73769, 73806, 74467, 74472, 74473, 74482, 74494, 74592, 74670, 74672, 74714, 74723, 74749, 74861 74892, 74893, 75176, 75705, 75989, 76027, 77949, 77974, 78167, 78310, 78415, 78575, 78590, 78709; 78875, 79864, 81316, 81320, 81409, 81737, 81843, 82102, 82833, 83461, 83624, 83660, 83701, 83708 83782, 85707, 85717, 86486, 86833, 87115, 87234, 87479, 87561, 87604, 87674, 87958, 87992, 88019 88074, 88079, 88115, 88118, 88120, 88135, 88142, 88143, 88149, 88340, 88344, 88512, 88521, 88650 88827, 89230, 89236, 90754, 90984, 91110, 92026, 92954, 93375, 93794, 94937, 95068, 96188, 97092 and 98812.
32. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in SEQ ID NO: 13 selected from the group consisting of 20300, 87958, 89236, 30267, 32657, 36289, 38869, 45051, 46257, 54112, 60307, 63499, 20891, 52699 and 71768.
33. The method of claim 1, wherein the one or more polymorphic variations are detected at one or more positions in Table B.
34. The method of claim 1, wherein the one or more polymorphic variations are detected at one ar more positions in linkage disequilibrium with one or more positions in claim 4, 7, 10, 13, 16, 19, 22, 25, 28, 31 or 33.
35. The method of claim 1, wherein detecting the presence or absence of the one or more 3θlymorphic variations comprises: hybridizing an oligonucleotide to the nucleic acid sample, wherein the oligonucleotide is complementary to a nucleotide sequence in the nucleic acid and hybridizes to a region adjacent to the Dolymorphic variation; extending the oligonucleotide in the presence of one or more nucleotides, yielding extension Droducts; and detecting the presence or absence of a polymorphic variation in the extension products.
36. The method of claim 1, wherein the subject is a human.
37. The method of claim 36, wherein the subject is a human femal .
38. The method of claim 36, wherein the subject is a human male.
39. A method for identifying a polymorphic variation associated with osteoarthritis proximal to in incident polymorphic variation associated with osteoarthritis, which comprises: identifying a polymorphic variation proximal to the incident polymorphic variation associated with osteoarthritis, wherein the polymorphic variation is detected in a nucleotide sequence selected from :he group consisting of: (a) a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the imino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (d) a fragment of a nucleotide sequence of (a), (b), or (c) comprising a polymorphic variation; determining the presence or absence of an association of the proximal polymorphic variant with asteoarthritis.
40. The method of claim 39, wherein the incident polymorphic variation is at one or more positions in claim 4, 7, 10, 13, 16, 19, 22, 25, 28, 31 or 33.
41. The method of claim 39, wherein the proximal polymorphic variation is within a region between about 5 kb 5' of the incident polymorphic variation and about 5 kb 3' of the incident polymorphic variation.
42. The method of claim 39, which further comprises determining whether the proximal polymorphic variation is in linkage disequilibrium with the incident polymorphic variation.
43. The method of claim 39, which further comprises identifying a second polymorphic variation proximal to the identified proximal polymorphic variation associated with osteoarthritis and determining if the second proximal polymorphic variation is associated with osteoarthritis.
44. The method of claim 43, wherein the second proximal polymorphic variant is within a region between about 5 kb 5' of the incident polymorphic variation and about 5 kb 3' of the proximal polymorphic variation associated with osteoarthritis.
45. An isolated nucleic acid comprising a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (d) a fragment of a nucleotide sequence of (a), (b), or (c) comprising a polymorphic variation; and (e) a nucleotide sequence complementary to the nucleotide sequences of (a), (b), (c), or (d); wherein the nucleotide sequence comprises a polymorphic variation associated with osteoarthritis selected from the group consisting of in SEQ ID NO: 2 an adenine at position 7219, a guanine at position 7485, an adenine at position 11839, a thymine at position 31899, an adenine at position 37000, a cytosine at position 48513, a guanine at position 49986, a guanine at position 56640, a cytosine at position 74407, a guanine at position 77398, an adenine at position 93060 and an adenine at position 97627; in SEQ ID NO: 3 an adenine at position 2215, a deletion at position 3369, a deletion at position 16642, a cytosine at position 20783, a cytosine at position 52155, a cytosine at position 55052, a cytosine at position 55941, a thymine at position 74333, an adenine at position 74741, a deletion at position 85366, a thymine at position 85469, a thymine at position 87687, an adenine at position 89660 and a cytosine at position 95718; in SEQ ID NO: 4 an adenine at position 6414, an adenine at positoin 51282, a cytosine at position 54574, a thymine at position 92029 and an adenine at position 96793; in SEQ ID NO: 5 a thymine at position 19083, a guanine at position 30900, an adenine at position 38356, an adenine at position 76512 and an adenine at position 94155; in SEQ ID NO: 6 a cytosine at position 5640, a cytosine at position 33150, an adenine at position 38247, a thymine at position 38529, an adenine at position 46846, a cytosine at position 49723, a cytosine at position 50050, a cytosine a position 63427, a guanine at position 73889, a thymine at position 189104, and an adenine at position rs428901; in SEQ ID NO: 7 an adenine at position 25414, a cytosine at position 25835, an adenine at position 38970, an adenine at position 41470, an adenine at position 44115, a guanine at position 47496, a cytosine at position 49038, an adenine at position 50204, a thymine at position 50840, a cytosine at position 50964, a cytosine at position 50971, an adenine at position 53906, a guanine at position 54149, a guanine at position 58415, a thymine at position 70796, a guanine at position 72325, a cytosine at position 75258, an adenine at position 77822, an adenine at position 80002, an adenine at position 85288, an adenine at position 85581, a guanine at position 86904, a guanine at position 90828, an adenine thymine adenine adenine sequence at position 94616, a cytosine at position 94712, a guanine at position 95869 and a cytosine at position 97856; in SEQ ID NO: 8 a thymine thymine repeat at position 56435, a thymine at position 59595, a cytosine at position 53292, a guanine at position 33159 and a thymine at position 41329; in SEQ ID NO: 10 a guanine at position 65073; in SEQ ID NO: 11 an adenine at position 47716 and a thymine at position 69793; in SEQ ID NO: 13 an adenine at position 20300, a thymine at position 46257, an adenine at position 89236, a guanine at position 30267, an adenine at position 32657, a cytosine at position 36289, a guanine at position 38869, a thymine at position 45051, a guanine at position 54112, an adenine at position 60307, a thymine at position 63499, a guanine at position 20891, a guanine at position 52699, and a cytosine at position 71768; and an allele associated with osteoporosis in Table B for positions rs910223, rs242392 and rs512294.
46. An oligonucleotide comprising a nucleotide sequence complementary to a portion of the nucleotide sequence of (a), (b), (c), or (d) in claim 45, wherein the 3' end of the oligonucleotide is adjacent to a polymorphic variation associated with osteoarthritis.
47. A microarray comprising an isolated nucleic acid of claim 45 linked to a solid support.
48. An isolated polypeptide encoded by the isolated nucleic acid sequence of claim 45.
49. A method for identifying a candidate therapeutic for treating osteoarthritis, which comprises: (a) introducing a test molecule to a system which comprises a nucleic acid comprising a nucleotide sequence selected from the group consisting of: (i) a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (ii) a nucleotide sequence which encodes a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (iii) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (iv) a fragment of a nucleotide sequence of (a), (b), or (c); or introducing a test molecule to a system which comprises a protein encoded by a nucleotide sequence of (i), (ii), (iii), or (iv); and (b) determining the presence or absence of an interaction between the test molecule and the nucleic acid or protein, whereby the presence of an interaction between the test molecule and the nucleic acid or protein identifies the test molecule as a candidate therapeutic for treating osteoarthritis.
50. The method of claim 49, wherein the system is an animal.
51. The method of claim 49, wherein the system is a cell.
52. The method of claim 49, wherein the nucleotide sequence comprises one or more polymorphic variations associated with osteoarthritis.
53. The method of claim 52, wherein the one or more polymorphic variations associated with osteoarthritis are at one or more positions in claim 4, 7, 10, 13, 16, 19, 22, 25, 28, 31 or 33.
54. A method for treating osteoarthritis in a subject, which comprises contacting one or more cells of a subject in need thereof with a nucleic acid, wherein the nucleic acid comprises a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (d) a fragment of a nucleotide sequence of (a), (b), or (c); and (e) a nucleotide sequence complementary to the nucleotide sequences of (a), (b), (c), or (d); whereby contacting the one or more cells of the subject with the nucleic acid treats the osteoarthritis in the subject.
55. The method of claim 54, wherein the nucleic acid is RNA or PNA.
56. The method of claim 55, wherein the nucleic acid is duplex RNA.
57. A method for treating osteoarthritis in a subject, which comprises contacting one or more cells of a subject in need thereof with a protein, wherein the protein is encoded by a nucleotide sequence which comprises a polynucleotide sequence selected from the group consisting of: (a) a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (d) a fragment of a nucleotide sequence of (a), (b), or (c); whereby contacting the one or more cells of the subject with the protein treats the osteoarthritis in the subject.
58. The method of claim 57, wherein the treatment comprises administration of an effective amount of a composition comprising an active ADAMTS2 polypeptide or fragment thereof, wherein the polypeptide fragment is selected from the group consisting of: 252-1211, 253-1211, 254-1211, 255-1211, 256-1211, 257-1211, 258-1211, 259-121 l or 260-1211 of SEQ ID NO: 44.
59. The method of claim 58, wherein the polypeptide or fragment has biological activity.
60. A method for treating osteoarthritis in a subject, which comprises: detecting the presence or absence of one or more polymorphic variations associated with osteoarthritis in a nucleic acid sample from a subject, wherein the one or more polymorphic variation are detected in a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (d) a fragment of a nucleotide sequence of (a), (b), or (c) comprising a polymorphic variation; and administering an osteoarthritis treatment to a subject in need thereof based upon the presence or absence of the one or more polymorphic variations in the nucleic acid sample.
61. The method of claim 60, wherein the one or more polymorphic variations are detected at one or more positions in claim 4, 7, 10, 13, 16, 19, 22, 25, 28, 31 or 33.
62. The method of claim 60, wherein the treatment is selected from the group consisting of administering a corticosteroid, a nonsteroidal anti-inflammatory drug (NSAID), a cyclooxygenase-2 (COX-2) inhibitor, an antibody, a glucocorticoid, hyaluronic acid, chondrotin sulfate, glucosamine or acetaminophen; prescribing a heat/cold regimen or a joint protection regimen; performing joint surgery; prescribing a weight control regimen; and combinations of the foregoing.
63. A method for detecting or preventing osteoarthritis in a subject, which comprises: detecting the presence or absence of one or more polymorphic variations associated with osteoarthritis in a nucleic acid sample from a subject, wherein the polymorphic variation is detected in a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (d) a fragment of a nucleotide sequence of (a), (b), or (c) comprising a polymorphic variation; and administering an osteoarthritis prevention or detection procedure to a subject in need thereof based upon the presence or absence of the one or more polymorphic variations in the nucleic acid sample.
64. The method of claim 63, wherein the one or more polymorphic variations are detected at one or more positions in claim 4, 7, 10, 13, 16, 19, 22, 25, 28, 31 or 33.
65. The method of claim 63, wherein the osteoarthritis prevention is selected from the group consisting of administering a corticosteroid, a nonsteroidal anti-inflammatory drug (NSAID), a cyclooxygenase-2 (COX-2) inhibitor, an antibody, a glucocorticoid, hyaluronic acid, chondrotin sulfate, glucosamine or acetaminophen; prescribing a heat/cold regimen or a joint protection regimen; performing joint surgery; prescribing a weight control regimen; and combinations of the foregoing.
66. A method of targeting information for preventing or treating osteoarthritis to a subject in need thereof, which comprises: detecting the presence or absence of one or more polymorphic variations associated with osteoarthritis in a nucleic acid sample from a subject, wherein the polymorphic variation is detected in a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (b) a nucleotide sequence which encodes a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B; (d) a fragment of a nucleotide sequence of (a), (b), or (c) comprising a polymoφhic variation; and directing information for preventing or treating osteoarthritis to a subject in need thereof based upon the presence or absence of the one or more polymorphic variations in the nucleic acid sample.
67. The method of claim 66, wherein the one or more polymorphic variations are detected at one or more positions in claim 4, 7, 10, 13, 16, 19, 22, 25, 28, 31 or 33.
68. A composition comprising a cell from a subject having osteoarthritis or at risk of osteoarthritis and an antibody that specifically binds to a protein, polypeptide or peptide encoded by a nucleotide sequence identical to or 90% or more identical to a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B.
69. The composition of claim 68, wherein the antibody specifically binds to an epitope comprising an amino acid encoded by rsl367117, rsl041973 and rs398829.
70. A composition comprising a cell from a subject having osteoarthritis or at risk of osteoarthritis and a RNA, DNA, PNA or ribozyme molecule comprising a nucleotide sequence identical to or 90% or more identical to a portion of a nucleotide sequence in SEQ ID NO: 1-13 or referenced in Table B.
71. The composition of claim 70, wherein the RNA molecule is a short inhibitory RNA molecule.
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168180B2 (en) 2002-11-27 2012-05-01 Technion Research & Development Foundation Ltd. Methods and compositions for modulating angiogenesis
US9382318B2 (en) 2012-05-18 2016-07-05 Amgen Inc. ST2 antigen binding proteins
WO2019210080A1 (en) * 2018-04-25 2019-10-31 The Regents Of The University Of California Methods and compositions for skeletal and neurological disorders
US10494443B2 (en) 2007-08-02 2019-12-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US20210246225A1 (en) * 2018-06-20 2021-08-12 Pharma Foods International Co., Ltd. Novel anti-pad2 antibody
US11267893B2 (en) 2018-07-16 2022-03-08 Regeneron Pharmaceuticals, Inc. Anti-IL36R antibodies

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010071405A1 (en) * 2008-12-18 2010-06-24 Erasmus University Medical Center Rotterdam Markers for detecting predisposition for risk, incidence and progression of osteoarthritis
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
CN102712683B (en) 2009-08-21 2014-09-10 吉联亚生物科技有限公司 Catalytic domains from lysyl oxidase and LOXL2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002366713A1 (en) * 2001-12-20 2003-07-09 Incyte Genomics, Inc. Nucleotide polymorphisms associated with osteoarthritis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of EP1756317A2 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168180B2 (en) 2002-11-27 2012-05-01 Technion Research & Development Foundation Ltd. Methods and compositions for modulating angiogenesis
US10494443B2 (en) 2007-08-02 2019-12-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US9382318B2 (en) 2012-05-18 2016-07-05 Amgen Inc. ST2 antigen binding proteins
US9982054B2 (en) 2012-05-18 2018-05-29 Amgen Inc. ST2 antigen binding proteins
US10227414B2 (en) 2012-05-18 2019-03-12 Amgen Inc. ST2 antigen binding proteins
US11059895B2 (en) 2012-05-18 2021-07-13 Amgen Inc. ST2 antigen binding proteins
US11965029B2 (en) 2012-05-18 2024-04-23 Amgen Inc. ST2 antigen binding proteins
WO2019210080A1 (en) * 2018-04-25 2019-10-31 The Regents Of The University Of California Methods and compositions for skeletal and neurological disorders
US20210246225A1 (en) * 2018-06-20 2021-08-12 Pharma Foods International Co., Ltd. Novel anti-pad2 antibody
US11267893B2 (en) 2018-07-16 2022-03-08 Regeneron Pharmaceuticals, Inc. Anti-IL36R antibodies

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