TW201632629A - Methods for cancer diagnosis and prognosis - Google Patents

Abstract

Disclosed herein are various methods for assessing the presence of ovarian tumor or malignant ovarian tumor, or the prognosis of the subject, based on the hypermethylation of one or more markers. Also disclosed herein are methods for determining whether a tissue sample derived from a subject is neoplastic based on the hypermethylation of one or more markers; said tissue sample is a bladder sample, breast sample, cervical scraping sample, colon sample, endometrium sample, liver sample, oral scraping sample, or osteosarcoma sample.

Description

Methods for cancer diagnosis and prognosis

The present disclosure relates to the diagnosis and prognosis of cancer. In particular, the present disclosure is a method for performing cancer diagnosis and prognosis evaluation based on the methylation status of a particular gene signature.

Among the common cancers among women, the incidence of ovarian cancer ranks fifth, and it is also the highest mortality rate among female reproductive cancers. Early symptoms of ovarian cancer are usually not obvious, so it is difficult to diagnose ovarian cancer at an early stage. Usually when ovarian cancer is diagnosed, the patient's course has reached a late stage, and the tumor has spread to organs other than the ovary. Specifically, about 90% of ovarian cancer cases develop from epithelial cells, and up to 70% of epithelial ovarian cancers have been diagnosed with stage III or IV.

If treated early, the 10-year survival rate of patients with stage I ovarian cancer treated is close to 90%. Conversely, the 5-year survival rate for stage III or IV ovarian cancer patients is only about 15%-20%. Therefore, early diagnosis of ovarian cancer can provide greater help to patients.

BRCA1 and BRCA2 gene mutations, Lynch syndrome, or women with a family history of ovarian cancer have a higher risk of developing ovarian cancer. These women's groups can use genetic counseling to assess potential risk of illness. For female populations with a high risk-related family history of BRCA1 or BRCA2 mutations, BRCA gene testing is usually required.

For female populations that are asymptomatic and do not have mutations associated with high risk of ovarian cancer, the commonly used screening techniques are vaginal ultrasound and serum cancer antigen-125 (CA-125). However, studies have indicated that these screenings do not reduce ovarian cancer mortality. Furthermore, the false positive rate of the above screening is high (about 10%), causing the individual to undergo unnecessary oophorectomy, which may cause serious complications. Because the current ovarian cancer screening has more harm than good, in 2012 the US Preventive Service Task Force recommended that serum CA-125 and vaginal ultrasound screening should not be performed on women with no symptoms and a high risk ratio.

In view of this, the current diagnostic test for ovarian cancer cannot effectively screen patients. Therefore, there is a need in the art for methods for diagnosing and evaluating prognosis of ovarian cancer.

SUMMARY OF THE INVENTION The Summary of the Disclosure is intended to provide a basic understanding of the present disclosure. This Summary is not an extensive overview of the disclosure, and is not intended to be an

A first aspect of the present disclosure is directed to a method of assessing the degree or malignancy of a tumor in a patient with an ovarian tumor.

According to an embodiment of the present disclosure, the method comprises the steps of: (a) collecting the same copy from the patient; (b) determining the methylation status of at least one of the target genes in the sample, wherein at least one of the target genes is selected from the following Group consisting of: TMEM132D (SEQ ID NO: 75), IRX1 (SEQ ID NO: 76), MIR124-2 (SEQ ID NO: 77), TRH (SEQ ID NO: 78), PCDHB4 (SEQ ID NO: 79), ZNF132 (sequence No.: 80), KLHL33 (sequence number: 81), DPP6 (sequence number: 82), ADCY8 (sequence number: 83), C20orf85 (sequence number: 84), C17orf46 (sequence number: 85), FOXI2 (sequence number: 86), HIST1H4I (sequence number: 87), HIST1H2BB (sequence number: 88), SLC6A3 (sequence number: 89), HTR1A (sequence number: 90), CDO1 (sequence number: 91), CDH8 (sequence number: 92) , PCDHGA5 (SEQ ID NO: 93), COL14A1 (SEQ ID NO: 94), SPAG6 (SEQ ID NO: 95), RAX (SEQ ID NO: 96), PRDM14 (SEQ ID NO: 97), HIST1H3E (SEQ ID NO: 98), ZIC1 (SEQ ID NO: 99), COX7A1 (sequence number: 100) and ECEL1P2 (sequence number: 101); (c) Determination of the Whether a target gene is highly methylated; and (d) assessing a patient's tumor malignancy or prognosis based on the result of step (c), wherein if the at least one target gene is highly methylated, the patient is judged to be malignant Ovarian tumors or poor prognosis.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (e) determining the methylation status of the GHSR gene (SEQ ID NO: 102); and (f) determining whether the GHSR gene is highly altered. In step (d), based on the results of steps (c) and (f), determining the degree of tumor malignancy or prognosis of the patient, wherein if the GHSR gene is highly methylated and the at least one target gene is generated Highly methylated, the patient is judged to have a malignant ovarian tumor or his prognosis is poor.

In some other embodiments, as desired, the method further comprises the steps of: (e) determining the methylation status of the HIST1 H3C gene; and (f) determining whether the HIST1H3C gene is hypermethylated; In step (d), the prognosis of the patient is determined based on the results of step (c) and step (f), wherein if the HIST1H3C is methylated and at least one of the HIST1H2BB, HIST1H3E or HIST1H4I is hypermethylated, the patient is determined Progression without disease progress.

According to various embodiments of the present disclosure, at least one of the underlying genes is highly methylated, possibly representing that the individual (1) has poor disease progression survival; or (2) poor overall survival.

In a specific embodiment, the at least one gene is TRH, the prognosis is associated with disease-free progression survival, and the method comprises the steps of: (e) determining a methylation status of a GHSR gene; and (f) determining Whether the GHSR gene is highly methylated, wherein in step (d), the prognosis of the patient is determined based on the results of steps (c) and (f), wherein if the GHSR gene is highly methylated and the TRH is highly Methylation determines that the patient has no disease progression and poor survival.

According to various embodiments of the present disclosure, the sample is a sample taken from a patient; or the sample is taken from a sample originally present in the patient; the patient is preferably a human; the sample comprises Tissue, tissue sample or cell sample (eg, tissue section, eg, aspiration biopsy, brush biopsy, surface biopsy, needle biopsy, puncture sample (punch) Biopsy), excision biopsy, open biopsy, incision biopsy, endoscopic biopsy, cervical scraping cells, urethral scraping Cells (uterus scraping cell or vaginal lavage), tumors, tumor samples, or biological fluids (eg, peritoneal fluid, blood (containing plasma), serum, lymph, spinal fluid). Specific to this disclosure In the embodiment, the sample is taken from the patient's ovarian tissue, cell samples (eg, cervical scraping cells), and body fluids (eg, serum and plasma).

A second aspect of the present disclosure relates to a method of assessing whether an individual has an ovarian tumor.

According to an embodiment of the present disclosure, the method comprises the steps of: (a) collecting the same copy from the individual; (b) determining the methylation status of at least one of the target genes in the sample, wherein the at least one target gene is selected from the following Groups composed: TMEM132D, IRX1, MIR124-2, TRH, PCDHB4, ZNF132, KLHL33, DPP6, ADCY8, C20orf85, C17orf46, FOXI2, HIST1H4I, HIST1H2BB, SLC6A3, HTR1A, CDO1, CDH8, PCDHGA5, COL14A1, SPAG6, RAX, PRDM14, HIST1H3E, ZIC1, COX7A1, and ECEL1P2; (c) determining whether the at least one target gene is highly methylated; and (d) evaluating whether the individual has an ovarian tumor based on the result of step (c), wherein When the at least one target gene is highly methylated, the individual is judged to have an ovarian tumor.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (e) determining a methylation status of the GHSR gene; and (f) determining whether the GHSR gene is highly methylated, wherein In the step (d), the tumor malignancy or prognosis of the individual is determined based on the results of the steps (c) and (f), wherein if the GHSR gene is highly methylated and the at least one target gene is highly methylated, Then the individual is judged to have an ovarian tumor.

In a specific embodiment, as desired, the sample is a serum or plasma sample, and in step (d), when the subject is obtained with an ovarian tumor, the method further comprises FOXI2, MIR- The methylation status of 124 or a combination thereof determines whether the ovarian tumor is malignant.

In other embodiments, as desired, the sample is taken from a cervical scraping cell and at least one of the underlying genes is selected from the group consisting of MIR124-2, TRH and FOXI2. In this example, when the result of the subject having the ovarian tumor is measured in step (d), the method further comprises determining the methylation status based on the MIR124-2, TRH, FOXI2, or a combination thereof. Whether the ovarian tumor is malignant.

According to various embodiments of the present disclosure, the sample is taken from a body; or the sample is taken from a sample that is already present in the individual; the individual is preferably a human; the sample contains tissue Tissue samples or cell samples (eg, tissue sections, eg, needle-suction, brush, slice, needle, puncture, excisional, open, incisional, endoscopic, sub- Cervical scraping cells, urethral scraping cells or vaginal lavage samples), tumors, tumor samples or biological fluids (eg, peritoneal fluid, blood (containing plasma), serum, lymph, spinal fluid). According to a particular embodiment of the present disclosure, the sample is taken from the individual's ovarian tissue, cell samples (eg, cervical scraping cells), and body fluids (eg, serum and plasma).

A third aspect of the present disclosure relates to a method of assessing whether an individual has malignant ovarian cancer.

According to an embodiment of the present disclosure, the method comprises the steps of: (a) collecting the same copy from the individual; (b) determining the methylation status of at least one of the target genes in the sample, wherein the at least one target gene is selected from the group consisting of a group consisting of: ADCY8, CDO1, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2; and (c) determining whether the at least one target gene is highly methylated, wherein at least one of the targets When the gene is highly methylated, the individual is judged to have malignant ovarian cancer.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (d) determining a methylation status of the GHSR gene; and (e) determining whether the GHSR gene is highly methylated, wherein When the GHSR gene and the at least one target gene are highly methylated, the individual is judged to have malignant ovarian cancer.

Further, the steps (d) and (e) shown in the above embodiment may be replaced by the following steps, or may further comprise the steps of: (f) determining the methylation status of the HIST1H3C gene; and (g) determining the Whether the HIST1H3C gene is highly methylated, wherein if the HIST1H3C gene and one of the GHSR genes are highly methylated and the at least one target gene is highly methylated, the individual is judged to have malignant ovarian cancer.

According to various embodiments of the present disclosure, the sample is taken from a body; or the sample is taken from a sample that is already present in the individual; the individual is preferably a human: the sample contains tissue Tissue samples or cell samples (eg, tissue sections, eg, needle-suction, brush, slice, needle, puncture, excisional, open, incisional, endoscopic, sub- Cervical scraping cells, urethral scraping cells or vaginal lavage samples), tumors, tumor samples or biological fluids (eg, peritoneal fluid, blood (containing plasma), serum, lymph, spinal fluid).

According to a particular embodiment of the present disclosure, the sample is taken from the individual's ovarian tissue, cell samples (eg, cervical scraping cells), and body fluids (eg, serum and plasma).

A fourth aspect of the invention relates to a method of assessing whether an individual has an ovarian tumor.

According to an embodiment of the invention, the method comprises the steps of: (a) collecting the same copy from the individual; (b) determining the methylation status of at least one of the target genes in the sample, wherein the at least one target gene is selected from the following a group consisting of: ADCY8, CDO1, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2; and (c) determining whether the at least one target gene is highly methylated; wherein the at least one target gene When hypermethylation occurs, the individual is judged to have an ovarian tumor.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (d) determining a methylation status of the GHSR gene; and (e) determining whether the GHSR gene is highly methylated; When the GHSR gene and at least one of the target genes are highly methylated, the individual is judged to have an ovarian tumor.

In a specific embodiment, if it is determined in step (c) that the subject to be tested has an ovarian tumor, the method further comprises determining whether the ovarian tumor is malignant based on the methylation status of the at least one target gene.

According to various embodiments of the present disclosure, the sample is taken from a body; or the sample is taken from a sample that is already present in the individual; the individual is preferably a human; the sample contains tissue Tissue samples or cell samples (eg, tissue sections, eg, needle-suction, brush, slice, needle, puncture, excisional, open, incisional, endoscopic, sub- Cervical scraping cells, urethral scraping cells or vaginal lavage samples), tumors, tumor samples or biological fluids (eg, peritoneal fluid, blood (containing plasma), serum, lymph, spinal fluid).

According to a particular embodiment of the present disclosure, the sample is taken from the individual's ovarian tissue, cell samples (eg, cervical scraping cells), and body fluids (eg, serum and plasma).

In a particular embodiment, as desired, the sample is a serum or plasma sample, and if the result of step (c) indicates that the individual has an ovarian tumor, the method further comprises FOXI2, MIR124-2 or The methylation status of the combination determines whether the ovarian tumor is malignant.

In other embodiments, as desired, the sample is taken from a cervical scraping cell and the at least one target gene is selected from the group consisting of MIR124-2, TRH and FOXI2. In this example, if the individual determined in step (d) has an ovarian tumor, the method further comprises determining whether the ovarian tumor is based on the methylation status of the MIR124-2, TRH, FOXI2, or a combination thereof Malignant.

A fifth aspect of the invention relates to a method of assessing whether an individual has malignant ovarian cancer.

According to an embodiment of the invention, the method comprises the steps of: (a) collecting the same from the individual, wherein the sample is taken from scraping the cells; (b) determining the methylation status of at least one of the target genes in the sample. , wherein at least one of the target genes is selected from the group consisting of TRH, FOXI2, and MIR124-2; and (c) determining whether the at least one target gene is highly methylated; wherein if at least one of the target genes is highly raised Upon methylation, the individual is judged to have malignant ovarian cancer.

In accordance with an embodiment of the present disclosure as desired, the method further comprises the steps of: (d) determining the methylation status of the GHSR gene using the method of step (b); and (e) utilizing the method of step (c) It is determined whether the GHSR gene is highly methylated; wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is judged to have malignant ovarian cancer.

A sixth aspect of the invention relates to a method of assessing whether an individual has an ovarian tumor.

According to an embodiment of the invention, the method comprises the steps of: (a) collecting the same from the individual, wherein the sample is taken from scraping the cells; (b) determining the methylation status of at least one of the target genes in the sample. , wherein at least one of the target genes is TRH or MIR124-2; and (c) determining whether the at least one target gene is highly methylated, wherein if the at least one target gene is highly methylated, the patient is determined to have an ovary Tumor.

In accordance with an embodiment of the present disclosure as desired, the method further comprises the steps of: (d) determining the methylation status of the GHSR gene using the method of step (b); and (e) utilizing step (c) The method determines whether the GHSR gene is highly methylated; wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is determined to have an ovarian tumor.

A seventh aspect of the present disclosure relates to a method of assessing whether an individual has malignant ovarian cancer.

According to an embodiment of the invention, the method comprises the steps of: (a) collecting a whole liquid sample from an individual; (b) determining a methylation status of at least one target gene in the body fluid sample, wherein the at least one target gene is FOXI2 or MIR124-2; and (c) determining whether the at least one target gene is highly methylated; wherein if the at least one target gene is highly methylated, the individual is judged to have malignant ovarian cancer.

According to an embodiment of the present disclosure as desired, the body fluid sample is a serum or plasma sample.

An eighth aspect of the invention relates to a method of assessing whether an individual has a bladder tumor using an individual's bladder sample.

According to an embodiment of the invention, the method comprises the steps of: (a) determining a methylation status of at least one of the target genes in the bladder sample, wherein the at least one target gene is selected from the group consisting of: ADCY8, C17orf46 , CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and Z1C1; and (b) determining whether the at least one target gene is highly Methylation; wherein if the at least one target gene is highly methylated, the bladder sample is determined to be a neoplastic sample.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (c) determining the methylation status of the GHSR gene in the bladder sample by the method of step (a); and (d) utilizing the step (b) The method determines whether the GHSR gene is highly methylated, wherein if the GHSR gene and the at least one target gene are highly methylated, the bladder sample is a neoplastic sample.

A ninth aspect of the invention relates to a method of assessing whether a breast tumor is diagnosed using an individual's breast sample.

According to an embodiment of the invention, the method comprises the steps of: (a) determining a methylation status of at least one target gene in a breast sample, wherein the at least one target gene is selected from the group consisting of: ADCY8, C17orf46 , CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and Z1C1; and (b) determining whether the at least one target gene is highly Methylation, wherein if the at least one target gene is highly methylated, the individual is determined to have a breast tumor.

In accordance with an embodiment of the present disclosure as desired, the method further comprises the steps of: (c) determining the methylation status of the GHSR gene in the breast sample using the method of step (a); and (d) utilizing the step (b) The method determines whether the GHSR gene is highly methylated; wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is determined to have a breast tumor.

A tenth aspect of the invention relates to a method of determining whether a subject has a cervical tumor using an individual's cervical scraping sample.

According to an embodiment of the invention, the method comprises the steps of: (a) determining a methylation status of at least one of the target genes in the cervical scraping sample, wherein the at least one target gene is selected from the group consisting of: ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and Z1C1; and (b) determining the at least one target gene Whether or not hypermethylation occurs, wherein if the at least one target gene is highly methylated, the individual is judged to have a cervical tumor.

In accordance with an embodiment of the present disclosure as desired, the method further comprises the steps of: (c) determining the methylation status of the GHSR gene in the cervical scraping sample using the method of step (a); And determining whether the GHSR gene is highly methylated by the method of the step (b), wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is judged to have a cervical tumor.

An eleventh aspect of the present invention relates to a method for determining whether an individual has a colorectal tumor using an individual's large intestine sample.

According to an embodiment of the invention, the method comprises the steps of: (a) determining a methylation status of at least one of the target genes in the large intestine sample, wherein the at least one target gene is selected from the group consisting of: ADCY8, C17orf46 , CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and Z1C1; and (b) determining whether the at least one target gene is highly Methylation, wherein if the at least one target gene is highly methylated, the individual is determined to have a colorectal tumor.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (c) determining the methylation status of the GHSR gene in the large intestine sample by the method of step (a); and (d) utilizing the step ( The method of b) determines whether the GHSR gene is highly methylated, wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is judged to have a colorectal tumor.

A twelfth aspect of the invention relates to a method of assessing whether an individual has an endometrial tumor.

According to an embodiment of the invention, the method comprises the steps of: (a) collecting the same copy from the individual; (b) determining the methylation status of at least one of the target genes in the sample, wherein the at least one target gene is selected from the following a group consisting of: CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, SPAG6, TRH, PRDM14, and Z1C1; and (c) determining whether the at least one target gene is highly methyl And wherein if the at least one target gene is highly methylated, the individual is determined to have endometrioma.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (d) determining the methylation status of the GHSR gene in the sample by the method of step (b); and (e) utilizing the step (c) The method determines whether the GHSR gene is highly methylated, wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is judged to have an endometrial tumor.

In a specific embodiment, the sample is taken from endometrial cells, and the at least one target gene is selected from the group consisting of PRDM14, TRH, MIR124-2, Z1C1, and FOXI2. In an embodiment as desired, the sample is taken from a cervical scraping cell, and the at least one target gene is selected from the group consisting of PRDM14, TRH, MIR124-2, Z1C1, and FOXI2 .

A thirteenth aspect of the invention relates to a method of determining whether an individual has a liver tumor using an individual's liver sample.

According to an embodiment of the invention, the method comprises the steps of: (a) determining a methylation status of at least one of the target genes in the liver sample, wherein the at least one target gene is selected from the group consisting of: ADCY8, C17orf46 , CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and Z1C1; and (b) determining whether the at least one target gene is highly Methylation; wherein if the at least one target gene is highly methylated, the individual is determined to have a liver tumor.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (c) determining the methylation status of the GHSR gene in the liver sample by the method of step (a); and (d) utilizing the step (b) The method determines whether the GHSR gene is highly methylated; wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is determined to have a liver tumor.

In a fourteenth aspect, the present invention relates to a method of determining whether an individual has an oral cavity using an oral scraping sample of a body.

According to an embodiment of the invention, the method comprises the steps of: (a) determining a methylation status of at least one of the target genes in the oral scraping sample, wherein the at least one target gene is selected from the group consisting of: ADCY8 , C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and Z1C1; and (b) determining whether the at least one target gene is A hypermethylation occurs; wherein if the at least one target gene is highly methylated, it is determined that the oral scraping sample is a neoplastic sample.

In accordance with an embodiment of the present disclosure as desired, the method further comprises the steps of: (c) determining the methylation status of the GHSR gene in the oral scraping sample using the method of step (a); and (d) utilizing The method of step (b) determines whether the GHSR gene is highly methylated, wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is judged to have a oral tumor.

A fifteenth aspect of the invention relates to a method of determining whether an individual has osteosarcoma using an individual's osteosarcoma sample.

According to an embodiment of the invention, the method comprises the steps of: (a) determining a methylation status of at least one of the target genes in the osteosarcoma sample, wherein the at least one target gene is selected from the group consisting of: ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and Z1C1; and (b) determining whether the at least one target gene has occurred Highly methylated.

According to an embodiment of the present disclosure as desired, the method further comprises the steps of: (c) determining the methylation status of the GHSR gene in the osteosarcoma sample by the method of the step (a); and (d) utilizing the steps The method of (b) determines whether the GHSR gene is highly methylated; wherein if the GHSR gene and the at least one target gene are highly methylated, the individual is determined to have osteosarcoma.

In an embodiment as desired, any aspect of the present disclosure, the step of determining the methylation status of a gene, can be accomplished by the following method: methylation-specific polymerase chain reaction (methylation-specific polymerase) Chain reaction; MSP), quantitative methylation-specific polymerase chain reaction (qMSP), bisulfite sequencing (BS), sulfite pyrosequencing (bisulfite pyrosequencing) , microarrays, mass spectrometry, denaturing high-performance liquid chromatography (DHPLC), pyrosequencing (pyrosequencing), methylated DNA immunoprecipitation and Quantitative polymerase chain reaction (methylated DNA immunoprecipitation (MeDIP or mDIP) coupled with quantitative polymerase chain reaction), methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing (nanopore) Sequencing).

The basic spirit and other objects of the present invention, as well as the technical means and implementations of the present invention, will be readily apparent to those skilled in the art of the invention.

The description of the embodiments of the present invention is intended to be illustrative and not restrictive. The features of various specific embodiments, as well as the method steps and sequences thereof, are constructed and manipulated in the embodiments. However, other specific embodiments may be utilized to achieve the same or equivalent function and sequence of steps.

The scientific and technical terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the invention pertains, unless otherwise defined herein.

Although numerical ranges and parameters are used to define a broad range of values for the present invention, the relevant values in the specific embodiments have been presented as precisely as possible. However, any numerical value inherently inevitably contains standard deviations due to individual test methods. As used herein, "about" generally means that the actual value is within plus or minus 10%, 5%, 1%, or 0.5% of a particular value or range. Alternatively, the term "about" means that the actual value falls within the acceptable standard error of the average, depending on the considerations of those of ordinary skill in the art to which the invention pertains. Except for the experimental examples, or unless otherwise explicitly stated, all ranges, quantities, values, and percentages used herein are understood (eg, to describe the amount of material used, the length of time, the temperature, the operating conditions, the quantity ratio, and the like. Are all modified by "about". Therefore, unless otherwise indicated to the contrary, the numerical parameters disclosed in the specification and the appended claims are intended to be At a minimum, these numerical parameters should be understood as the number of significant digits indicated and the values obtained by applying the general carry method.

In addition, the singular noun used in this specification covers the plural of the noun in the case of no conflict with the context; the plural noun of the noun is also included in the plural noun used. In addition, the words "at least one" and "one or more" are used herein to include one, two, three or more.

The term "diagnosis" as used herein refers to the identification of a pathological condition, disease or condition, such as a tumor or neoplasm of a different tissue source, including the ovary, bladder, breast, cervix, large intestine, endometrium, Liver, oral tissue, osteosarcoma and soft tissue. In some instances, the term "diagnosis" refers to the identification of malignant and benign tumors.

The term "prognosis" refers to predicting the death or cancer progression caused by cancer, including recurrence rate and metastatic spread of a neoplastic disease, and recurrence-free survival of tumor patients. The recurrence-free survival time, progression-free time, or overall survival time. According to a particular embodiment of the present disclosure, the "prognosis" refers to recurrence-free survival (RFS), progression-free survival (PFS), or overall survival (overall survival; OS). Furthermore, the term "poor prognosis" refers to an individual whose expected prolonged life expectancy is significantly lower than that of one or more of the underlying genes. In other embodiments, an individual's "RFS poor" means that the individual's RFS period is less than 12 or 24 months. Similarly, "poor overall survival" or "poor progression without disease progression" means that the individual has less than 12 or 24 months of OS or PFS. Alternatively, poor RFS or PFS may mean that the probability of recurrence or worsening of an individual with a poor RFS or PFS is higher in a particular period than in a control individual.

In the present disclosure, the term "tumor, neoplasm or neoplasm" refers to abnormally new cells or abnormally growing cells that grow faster than normal cells. Tumors produce benign unstructured masses (ie, benour tumors) or malignant unstructured masses (eg, cancer). The term "benign" refers to a non-cancerous tumor or tumor, for example, cells do not invade surrounding tissues or metastasize to distant places; and "malignant" refers to metastatic tumors or tumors that can invade surrounding tissues. And is not controlled by normal cell growth.

As used herein, the term "cancer" refers to all types of cancer or malignant neoplasm or tumor in an animal, including leukemia, malignant epithelial cell carcinoma, melanoma, and sarcoma. . In accordance with various embodiments of the present disclosure, the methods disclosed herein relate to the diagnosis and/or prognosis of one or more malignancies and sarcomas. The "malignant tumor" or "cancer" refers to a malignant tumor or cancer derived from epithelial cells. For example, the malignant tumor or cancer shown in various embodiments of the present disclosure includes, but is not limited to, ovarian cancer, cervical cancer, endometrial cancer, breast cancer, hepatocellular malignancy, bladder cancer, colon cancer, and oral cavity. cancer. The "sarcoma" generally refers to a malignant tumor that develops from osteosarcoma, cartilage (ie, chondrosarcoma) or soft tissue (eg, fat, muscle, nerve, fibrous tissue, blood vessels, or deep skin tissue).

When the C5 position of the cytosine in the CpG dinucleotide located in the core promoter region of the gene is covalently bonded to the methyl group, it is called "methylation". The "methylation state" refers to the presence or absence of 5-methyl-cytosine (5-mCyt) on one or more CpG dinucleotides within a gene or a nucleic acid sequence of interest. As used herein, "methylation level" refers to the amount of methylation in one or more copies of a gene or nucleic acid sequence. The degree of methylation of the gene or nucleic acid sequence of interest can be expressed as an absolute value. Furthermore, the concept of "relative methylation level" can also be used, in which the amount of methylated DNA is expressed relative to the total amount of DNA, or a copy of a gene or nucleic acid sequence indicating methylation. The number of copies relative to the total number of copies of the gene or nucleic acid sequence. In addition, "methylation level" refers to the percentage of methylated CpG sites in the DNA fragment of interest.

As used herein, "methylation profile" refers to a set of data relating to the degree of methylation of one or more of the target genes in a sample. In certain embodiments, the methylation profile is a map compared to a methylated reference map taken from an unknown type of sample, such as a cancerous sample or a non-cancerous sample or a different cancer stage Sample.

Here, "differential methylation" refers to the degree of methylation of one or more target genes in a sample or population and the degree of methylation of one or more target genes in other samples or populations. There are differences. Differential methylation can be distinguished by an increased degree of methylation (hypermethylation) or a decrease in the degree of methylation (hypomethylation). Here, "highly methylated" means that the degree of methylation of the target gene in the test sample is increased by at least 10% compared to the average methylation degree of the target gene in the reference sample. According to various embodiments of the present disclosure, the increased degree of methylation means an increase of at least 15, 20, 25, 30, 35, 40, 45 or 50%.

The "percent (%) sequence identity" as used herein for a nucleotide sequence means that the nucleotide residue of a candidate sequence is identical to the nucleotide residue of a reference polynucleotide sequence. Percentage. When performing the above alignment, the candidate sequence may be side by side with the reference polynucleotide sequence, and a gap may be introduced as necessary to form the highest sequence similarity of the two sequences, and when calculating the similarity, Conservative substitutions are considered to be the same nucleotide. A variety of methods are available for the above-described side-by-side, such as publicly available software such as BLAST, BLAST-2, ALIGN or Megalign (DNASTAR). Those skilled in the art to which the present invention pertains may select appropriate parameters and calculation methods when performing side-by-side to obtain an optimal arrangement. The nucleotide sequence similarity of a candidate polynucleotide sequence A compared to a reference polynucleotide sequence B (also referred to herein as sequence A and sequence B have a specific percentage (%) of nucleotide sequence similarity Degree) is calculated as follows: % where X is the identical nucleotide match obtained by arranging sequences A and B using the Blastp or Blastn analysis database, and Y is the shorter nucleotide of the A and B sequences. The total number of residues.

It will be understood that all of the genes or polynucleotide sequences herein comprise different variants, respectively, which have at least 75% nucleotide sequence similarity to the gene or polynucleotide sequence. Furthermore, the gene or polynucleotide sequence of the present disclosure may be replaced by the term "polynucleotide having at least 75% nucleotide sequence similarity", unless otherwise indicated.

The term "subject" or "patient" refers to an animal, including a human, that can be diagnosed and/or prognosed using the methods of the invention. Unless otherwise specified, "individual" or "patient" covers both male and female animals.

The term "sample" as used herein includes any sample taken from an individual or patient. In accordance with the methods of the present disclosure, the sample comprises a DNA molecule that is capable of determining the degree of methylation. For example, the sample taken from an individual or a patient includes, but is not limited to, blood, smears, sputum, urine, feces, body fluids, bile, gastrointestinal secretions, lymph, osteosarcoma bone marrow, organ extraction And or tissue sections. These samples taken from an individual or patient can be determined using techniques well known to those of ordinary skill in the art. Furthermore, it is well known in the art that DNA can be isolated from the sample using known methods and reagents, such as extraction of DNA using phenol/chloroform or in a commercial kit.

At least a portion of the present disclosure is based on the discovery of the degree of differential methylation (especially hypermethylation) of one or more target genes in an individual as a function of tumor progression and tumorigenesis. Furthermore, these target genes can be used alone or in combination as biomarkers for predicting the risk or susceptibility of an individual to have a tumor or tumor, determining whether the tumor or tumor is malignant and/or assessing the prognosis of the tumor or neoplastic patient. Furthermore, individualized treatment guidelines can be developed based on the degree of methylation of related genes in the patient. For example, a patient with one or more highly methylated genes can be treated with a demethylating agent or other epigenetic drug to treat the tumor or tumor.

In view of this, the present disclosure provides various diagnostic and/or prognostic methods, which are listed below, respectively. For example, all methods herein encompass the determination of the methylation status or degree of methylation of at least one of the underlying genes. Therefore, the common steps in most (or all) of the requested methods are explained below.

According to various aspects and/or embodiments of the present disclosure, the method is applied to a body, and the usual steps include: a sampling step (a), wherein the biological sample sampled at the step is taken from the individual Measuring at least one methylation step (b), the step of determining the methylation status of at least one of the target genes in the sample; and at least one determining step (c), the step determining whether at least one of the target genes is highly methylated. The method according to some embodiments of the present invention directly uses biological samples, such as tissue section samples, cervical scraping cells, and body fluid samples (eg, blood or urine); in this case, the sampling step of step (a) may be omitted. . Next, the resulting methylation profile is used to diagnose and/or assess prognosis in accordance with various aspects and embodiments of the present disclosure.

In a first aspect, the present disclosure provides a method of assessing the degree of malignancy or prognosis of a tumor in an ovarian tumor patient, comprising the above-described common steps (a), (b) and (c), and an evaluation step (d), wherein The method is based on the results of step (c) determination to assess the degree of tumor malignancy or prognosis in an individual. Specifically, when at least one of the target genes is highly methylated, it is determined that the patient has a malignant ovarian tumor or has a poor prognosis.

According to various embodiments of the present disclosure, the at least one target gene is selected from the group consisting of: TMEM132D, IRX1, MIR124-2, TRH, PCDHB4, ZNF132, KLHL33, DPP6, ADCY8, C20orf85, C17orf46, FOXI2, HIST1H4I, HIST1H2BB, SLC6A3, HTR1A, CDO1, CDH8, PCDHGA5, COL14A1, SPAG6, RAX, PRDM14, HIST1H3E, ZIC1, COX7A1 and ECEL1P2.

According to an optional embodiment of the present disclosure, the method further comprises a second methylation assay step (e), wherein the step (e) is determining the methylation status of the GHSR gene; and the second determining step (f) ), this step is to determine whether the GHSR gene is highly methylated.

In an embodiment implemented as desired, the evaluating step (d) is based on the results of steps (c) and (f) to determine the degree of tumor malignancy or prognosis of the individual. Specifically, the hypermethylation of the GHSR gene and the hypermethylation of at least one of the underlying genes determine that the individual has a malignant ovarian tumor or has a poor prognosis. For example, the at least one target gene used in combination with the GHSR gene can be a TRH gene, and the GHSR and TRH can be used to effectively assess the disease-free progression survival of the individual. The results revealed by the following examples demonstrate that simultaneous assessment of a patient's malignancy or prognosis of a GHSR gene methylation profile can improve accuracy. Furthermore, this embodiment can be used in combination with other embodiments of the present disclosure.

It will be appreciated that the first and second methylation assay steps can be performed simultaneously or sequentially in a single process or in a separate process. Similarly, the first and second assay steps can be performed simultaneously or sequentially. It will be appreciated that the steps described above in terms of sequential completion or the processes required to perform these steps are also applicable to other embodiments described herein.

According to various embodiments of the present disclosure, hypermethylation of at least one of the underlying genes indicates (1) no disease progression survival or (2) poor overall survival.

In an embodiment as desired, the at least one target gene is selected from the group consisting of ADCY8, CDO1, HIST1H4I, ECEL1P2, HTR1A, SPAG6, CDH8, DPP6, HIST1H3E, PCDHGA5, RAX, C17orf46, COL14A1, FOXI2, PRDM14, ZIC1, HIST1H2BB, MIR124-2, and TRH, and at least one of the underlying genes is highly methylated, and the individual is judged to have a malignant ovarian tumor.

In another embodiment, which is optionally carried out, the at least one target gene is selected from the group consisting of MIR124-2, TRH, PCDHB4, ZNF132, KLHL33, C20orf85, C17orf46, HIST1H4I, HIST1H2BB, CDO1. CDH8, PCDHGA5, COL14A1, SPAG6, HIST1H3E, ZIC1, COX7A1 and ECEL1P2, and at least one of the underlying genes is highly methylated, and the individual is judged to have poor disease progression and poor survival.

Furthermore, the at least one target gene is selected from the group consisting of: TMEM132D, IRX1, KLHL33, DPP6, ADCY8, FOXI2, SLC6A3, HTR1A, CDO1, CDH8, RAX, and PRDM14, and at least one of the target gene heights Methylation determines that the individual's overall survival is poor.

In embodiments specifically contemplated as desired, the at least one target gene is selected from the group consisting of HIST1H2BB, HIST1H3E, and HIST1H4I. The marker combination is particularly useful for assessing the disease-free progression survival of an individual. Furthermore, in yet another embodiment, two or three genes in the HIST1H2BB, HIST1H3E, and HIST1H4I genes are highly methylated, and the disease-free survival of the individual is determined to be poor.

Furthermore, the combination of the above markers can additionally be used in conjunction with related markers (eg, the HIST1H3C gene). According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (e), wherein the step is to determine the methylation status of the HIST1H3C gene; and a second assay step (f), This step is to determine if the HIST1H3C gene is highly methylated. In this embodiment, the evaluating step (d) is based on the measurement results of the steps (c) and (f) to determine the degree of tumor malignancy or prognosis of the individual. Specifically, when the HIST1H3C gene is highly methylated and the above marker combination is highly methylated, it is determined that the individual has no disease progression and poor survival.

In certain embodiments, the sample is taken from an individual's body fluid (eg, serum or plasma). In this example, the subject gene is FOXI2, MIR124-2, or a combination thereof.

In certain other embodiments, the sample is obtained from an individual's ovarian tissue (eg, from a cervical scraping cell) and the subject gene is MIR124-2, TRH, FOXI2, or a combination thereof. Furthermore, the evaluating step (d) is based on a GHSR methylation profile and a methylation profile consisting of at least one of the underlying genes selected from the group consisting of MIR124- 2. TRH and FOXI2.

Methods for determining the methylation status of a gene according to various embodiments of the present disclosure, including but not limited to: methylation specificity polymerase chain reaction (MSP), quantitative methylation specificity polymerase chain reaction (qMSP) , sulfite sequencing (BS), sulfite pyrophosphate sequencing, microarray, mass spectrometry, denaturing high liquid chromatography, pyrophosphate sequencing, methylated DNA immunoprecipitation and quantitative polymerase Chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing.

In an embodiment of the present disclosure, the methylation status is determined using qMSP or sulfite pyrophosphate sequencing. It will be understood that the methods of the present invention are not limited to the various assay methods described above; further, the scope of the present invention encompasses other methods that are the same or similar to quantify the methylation status or extent of a particular gene. Furthermore, the above methods or similar steps can be applied to the following other embodiments; therefore, in the following aspects/embodiments, the same or similar methods for determining the methylation status or degree of methylation of a gene are not otherwise Narration.

The present disclosure provides a method of assessing whether an individual has an ovarian tumor. The method comprises the above-described common steps (a), (b) and (c), and an evaluation step (d), wherein the step (d) is based on the result of the determination of the step (c) to determine whether the individual has an ovarian tumor. Specifically, if at least one of the target genes is highly methylated, the individual is judged to have an ovarian tumor.

According to various embodiments of the present disclosure, the at least one target gene is selected from the group consisting of: TMEM132D, IRX1, MIR124-2, TRH, PCDHB4, ZNF132, KLHL33, DPP6, ADCY8, C20orf85, C17orf46, FOXI2, HIST1H4I, HIST1H2BB, SLC6A3, HTR1A, CDO1, CDH8, PCDHGA5, COL14A1, SPAG6, RAX, PRDM14, HIST1H3E, ZIC1, COX7A1 and ECEL1P2. In certain embodiments, as desired, the at least one target gene is selected from the group consisting of MIR124-2, CDO1, HTR1A, and TRH.

In embodiments in which the disclosure is performed as desired, the method further comprises a second methylation assay step (e) and a second assay step (f) associated with the methods of the present disclosure.

In the embodiment carried out as needed, the evaluation step (d) is based on the measurement results of the steps (c) and (f), and determines whether the individual has an ovarian tumor. Specifically, when the GHSR gene is highly methylated and at least one of the target genes is highly methylated, the individual is judged to have an ovarian tumor. For example, the GHSR gene and the MIR124-2 gene can be used in combination to assess whether an individual has an ovarian tumor to obtain a better and more accurate diagnosis. It will be appreciated that the embodiments disclosed herein can be used in conjunction with any of the other embodiments.

In certain embodiments, the sample is taken from an individual's body fluid (eg, serum or plasma). In this example, the target gene can be FOXI2, MIR124-2, or a combination thereof. In yet another embodiment as desired, when the result of step (d) indicates that the individual has an ovarian tumor, the method further comprises determining whether the ovarian tumor is based on the methylation status of FOXI2, MIR-124 or a combination thereof Malignant.

In certain other embodiments, the sample is taken from an individual ovarian tissue (eg, from a cervical scraping cell) and the subject gene is MIR124-2, TRH, FOXI2, or a combination thereof. Further, the evaluating step (d) is carried out based on a GHSR and a methylation profile of at least one of the target genes selected from the group consisting of MIR124-2, TRH and FOXI2. In an embodiment as desired, if the individual determined in step (d) has an ovarian tumor, the method further comprises: determining the ovary based on methylation status of MIR124-2, TRH, FOXI2, or a combination thereof Whether the tumor is malignant.

In a third aspect, the present disclosure is directed to a method of assessing whether an individual has malignant ovarian cancer. Based on the various embodiments of the present disclosure, based on the results of step (c), it is determined whether the ovarian cancer is malignant. In particular, the at least one target gene shows hypermethylation. Then, the individual is judged to have malignant ovarian cancer.

Further, in various embodiments, the at least one target gene is selected from the group consisting of ADCY8, CDO1, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2.

An embodiment implemented as needed according to the present disclosure further includes a second methylation assay step (d) for determining the methylation status of the GHSR gene; and a second assay step (e), The step is to determine if the GHSR gene is highly methylated. In this example, the degree of tumor malignancy of the individual is determined based on the results of steps (c) and (e). Specifically, the GHSR gene is highly methylated, and at least one of the target genes is highly methylated, and the individual is judged to have malignant ovarian cancer. The results revealed in the following examples demonstrate that when assessing the malignancy of ovarian cancer, the methylation profile of the GHSR gene can be combined to make the results of the assessment more accurate. Again, this embodiment can be used in conjunction with other embodiments described herein.

In an embodiment as desired, in accordance with a particular embodiment of the present disclosure, further comprising a second methylation assay step (f) for determining the methylation status of the HIST1 H3C gene; and a second assay step (g), this step is to determine whether the HIST1H3C gene is highly methylated. In this example, the degree of tumor malignancy of the individual is determined based on the results of the determination of step (c) and step (g). In a specific embodiment, the hypermethylation of the HIST1 H3C gene and the hypermethylation of at least one gene determine that the individual has malignant ovarian cancer. For example, combining the GHSR gene and the methylation profile of the HIST1H3C gene can more accurately assess whether ovarian cancer is malignant. Furthermore, the present embodiment can be used in combination with any of the other embodiments.

For example, in other embodiments implemented as desired, steps (a), (b), (c), (d), (e), and (f) are performed, and based on steps (c), (e) And (g) the results of the evaluation of the prognosis of the degree of malignancy of ovarian cancer. In other words, if at least one of the target genes is highly methylated, and at least one of the HIST1H3C gene and the GHSR gene is highly methylated, the individual is judged to have malignant ovarian cancer.

In a specific embodiment, the methylation status of CDO1, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2 is determined in step (b), and the methylation profile of these markers is determined alone, or The GHSR gene and/or the HIST1H3C gene methylation profile assesses the prognosis of the malignant degree of individual ovarian cancer.

In certain embodiments, the methylation status of CDO1, FOXI2, TRH, and MIR124-2 is determined in step (b), and the methylation profile of these markers is determined alone, or the methylation profile of the GHSR gene is assessed. The prognosis of the malignant degree of individual ovarian cancer.

In certain embodiments, the sample is taken from an individual's body fluid (eg, serum or plasma). In this embodiment, the target gene can be FOXI2, MIR124-2, or a combination thereof.

In certain other embodiments, the sample is taken from an individual's ovarian tissue (eg, from a cervical scraping cell) and the subject gene is MIR124-2, TRH, FOXI2, or a combination thereof. Furthermore, the prognosis of the malignant degree of individual ovarian cancer is evaluated based on the methylation profile of the GHSR gene and at least one of the underlying genes, wherein at least one of the underlying genes is selected from the group consisting of MIR124-2, TRH and FOXI2.

It will be appreciated that if the subject being tested is not suffering from malignant ovarian cancer, the method (or related step) shown in the fourth aspect of the disclosure can determine whether the individual has an ovarian tumor.

In a fourth aspect, the invention relates to a method for assessing whether an individual has an ovarian tumor (benign or malignant), in step (c) of the method, if at least one of the target genes is highly methylated, the individual is determined Suffering from ovarian tumors.

According to various embodiments, the at least one target gene is selected from the group consisting of ADCY8, CDO1, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2.

According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d), the step of determining the methylation status of the GHSR gene; and a second assay step (e), The step is to determine if the GHSR gene is highly methylated.

In this embodiment, the diagnosis is performed based on the measurement results of the steps (c) and (e). In particular, the hypermethylation of the GHSR gene and the hypermethylation of at least one of the underlying genes indicate that the individual has an ovarian tumor (benign or malignant). The results as described in the examples below show that combining the results of the methylation profile of the GHSR gene allows for a more accurate assessment of whether an individual has an ovarian tumor. Furthermore, this embodiment can be used in combination with other embodiments.

In a specific embodiment, the methylation status of ADCY8, CDO1, HIST1H2BB, HIST1H3E, HTR1A, TRH, FOXI2, and MIR124-2 is determined in step (b), and the methylation profile of the markers is used alone, or The markers and the methylation profile of the GHSR gene are used together to diagnose whether the individual has an ovarian tumor.

In certain embodiments, the methylation status of CDO1, HTR1A, TRH, and MIR124-2 is determined by step (b), and the methylation profile of the markers is used alone, or the markers and the GHSR gene are used in combination Methylation map to diagnose whether the individual has an ovarian tumor.

In certain embodiments, the sample is taken from an individual's body fluid (eg, serum or plasma). In this embodiment, the target gene can be FOXI2, MIR124-2, or a combination thereof. In an embodiment implemented as desired, if the result of step (c) indicates that the individual has an ovarian tumor, the method further comprises determining whether the ovarian tumor is malignant based on the methylation status of FOXI2, MIR-124 or a combination thereof. .

In certain other embodiments, the sample is obtained from an individual's ovarian tissue (eg, from a cervical scraping cell), and the target gene is selected from the group consisting of: MIR124-2 , TRH and FOXI2. Furthermore, the prognosis of the malignant degree of the individual ovarian cancer can be assessed based on the methylation profile of the GHSR gene and at least one of the target genes, wherein the at least one target gene is selected from the group consisting of MIR124-2, TRH and FOXI2 . In this embodiment, when the individual determined in step (c) is suffering from an ovarian tumor, the method further comprises determining whether the ovarian tumor is malignant based on the methylation status of MIR124-2, TRH, FOXI2, or a combination thereof.

In embodiments as desired, if the subject to be tested has an ovarian tumor, the method further comprises determining whether the ovarian tumor is malignant based on a methylation status of at least one of the target genes. For example, the method (or related steps) described in the third aspect of the disclosure relates to determining whether an ovarian tumor is malignant.

In a fifth aspect, the present disclosure provides a method of diagnosing whether an individual is suffering from malignant ovarian cancer. According to various embodiments of the present disclosure, in step (a) the sample is taken from a cervical scraping cell and at least one of the underlying genes is selected from the group consisting of TRH, FOXI2 and MIR124 -2, and determining the degree of malignancy of ovarian cancer based on the measurement result of step (c). In particular, at least one of the underlying genes is highly methylated, indicating that the individual has malignant ovarian cancer.

As with the related embodiments shown in the second aspect of the present disclosure, the degree of malignancy of ovarian cancer can be further evaluated by the GHSR gene expression profile. Specifically, if the GHSR gene and at least one of the target genes are highly methylated, the individual is determined to have malignant ovarian cancer, wherein the at least one target gene is selected from the group consisting of TRH, FOXI2, and MIR124-2.

A sixth aspect of the invention relates to a method of assessing whether an individual has ovarian cancer. According to various embodiments of the present disclosure, the sample of step (a) is taken from a cervical scraping cell, and at least one of the target genes is TRH or MIR124-2, and at least one of the determined ones in step (c) If the target gene is highly methylated, it is determined that the individual has an ovarian tumor.

Similar to the third aspect related embodiment of the present disclosure, the method can further determine whether the patient has an ovarian tumor (whether benign or malignant) with reference to the GHSR gene expression profile. Specifically, if the GHSR gene is highly methylated and at least one gene of TRH or MIR124-2 is highly methylated, the highly methylated individual has malignant ovarian cancer.

In a seventh aspect, the invention relates to a method of assessing whether an individual has malignant ovarian cancer. According to various embodiments of the present disclosure, the sample used in step (a) is a body fluid sample, and at least one of the target genes is FOXI2, MIR124-2 or a combination thereof; further, the ovarian cancer is determined based on the result of step (c) Whether it is malignant. In a specific embodiment, at least one of the underlying genes is hypermethylated, and the individual is determined to have malignant ovarian cancer.

According to an embodiment of the present disclosure as desired, the body fluid sample is a serum or plasma sample.

In an eighth aspect, the invention relates to a method of assessing whether an individual has a bladder tumor using a single bladder sample. According to various embodiments of the present disclosure, the sample used in step (a) is a bladder sample, and the at least one target gene is ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and Z1C1, and if at least one of the underlying genes is highly methylated, the individual is judged to have a bladder tumor.

According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d), wherein the step is to determine the methylation status of the GHSR gene; and a second assay step (e) ), this step is to determine whether the GHSR gene is highly methylated. In this embodiment, the diagnosis is based on the results of step (c) and step (e). In particular, the hypermethylation of the GHSR gene and the hypermethylation of at least one of the underlying genes determine that the individual has a bladder tumor (ie, the individual may have a benign or malignant bladder tumor).

In an eighth aspect, the invention relates to a method of assessing whether a breast tumor is present using a breast sample of a body. According to various embodiments of the present disclosure, the sample utilized in step (a) is a breast sample, and at least one of the target genes is ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH, and Z1C1; further, if at least one of the target genes is highly methylated, the individual is judged to have a breast tumor.

According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d), wherein the step is to determine the methylation status of the GHSR gene; and a second assay step (e) ), this step is to determine whether the GHSR gene is highly methylated. In this embodiment, the diagnosis is based on step (c) and step (e). Specifically, if the GHSR gene is highly methylated and at least one of the underlying genes is highly methylated, the individual is judged to have a breast tumor (ie, the individual may have a benign or malignant breast tumor).

In a tenth aspect, the invention relates to a method of determining whether a subject has a cervical tumor using a single cervical scraping sample. According to various embodiments of the present disclosure, the sample of step (a) is taken from a cervical scraping cell, and at least one of the target genes is ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH or Z1C1; further, if at least one of the target genes is highly methylated, the individual is judged to have a cervical tumor.

In accordance with an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d) for determining the methylation status of the GHSR gene; and a second assay step (e) This step is to determine whether the GHSR gene is highly methylated. In this embodiment, the diagnosis is based on the results of step (c) and step (e). In particular, hypermethylation of the GHSR gene, as well as hypermethylation of at least one of the underlying genes, indicates that the individual has a cervical tumor (ie, the individual may have a benign or malignant cervical tumor).

In an eleventh aspect, the present invention relates to a method of determining whether an individual has a colorectal tumor using a large intestine sample of a body. According to various embodiments of the present disclosure, the sample used in step (a) is a large intestine sample, and at least one of the target genes is ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH or Z1C1; further, if at least one of the underlying genes is highly methylated, the individual is judged to have a colorectal tumor.

According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d), wherein the step is to determine the methylation status of the GHSR gene; and a second assay step (e) ), this step is to determine whether the GHSR gene is highly methylated. In this embodiment, the diagnosis is based on the results of step (c) and step (e). Specifically, the GHSR gene and at least one of the target genes are highly methylated. The individual is then judged to have a colorectal tumor (ie, the individual may have a benign or malignant colorectal tumor).

In a twelfth aspect, the invention relates to a method of assessing whether an individual has an endometrial tumor. According to various embodiments of the present disclosure, the sample used in step (a) is an endometrial sample, and at least one of the target genes is CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H3E, HIST1H4I, HTR1A, MIR124. - 2, SPAG6, TRH, PRDM14, TRH or Z1C1; further, if at least one of the target genes is highly methylated, the individual is judged to have endometrioma. In a preferred embodiment, the at least one target gene can be PRDM14, TRH, MIR124-2, Z1C1 or FOXI2.

In an embodiment as desired, the sample may be taken from a cervical scraping cell, and at least one of the target genes is selected from the group consisting of: PRDM14, TRH, MIR124-2, Z1C1, and FOXI2; Furthermore, if at least one of the target genes is highly methylated, the individual is judged to have endometrial tumors.

According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d), wherein the step is to determine the methylation status of the GHSR gene; and a second assay step (e) ), this step is to determine whether the GHSR gene is highly methylated. In this embodiment, the diagnosis is based on the results of step (c) and step (e). In particular, the hypermethylation of the GHSR gene and the hypermethylation of at least one of the underlying genes indicate that the individual has an endometrial tumor (ie, the individual may have a benign or malignant endometrial tumor).

In a thirteenth aspect, the invention relates to a method of determining whether an individual has a liver tumor using a liver sample of a body. According to various embodiments of the present disclosure, the sample of the step (a) is a liver sample, and at least one of the target genes is ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I. , HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH or Z1C1; further, if at least one of the target genes is highly methylated, the individual is judged to have a liver tumor.

According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d), wherein the step is to determine the methylation status of the GHSR gene; and a second assay step (e) ), this step is to determine whether the GHSR gene is highly methylated. In this embodiment, the diagnosis is based on step (c) and step (e). In particular, the hypermethylation of the GHSR gene and the hypermethylation of at least one of the underlying genes determine that the individual has a liver tumor (ie, the individual may have a benign or malignant liver tumor).

In a fourteenth aspect, the invention relates to a method of determining whether an individual has an oral cavity using a single oral scraping sample. According to various embodiments of the present disclosure, the sample utilized in step (a) is an oral scraping sample, and at least one of the target genes is ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB. , HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH or Z1C1; further, if at least one of the target genes is highly methylated, it is determined that the oral scraping sample of the individual is a neoplastic sample. And the individual has a mouth tumor.

According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d), wherein the step is to determine the methylation status of the GHSR gene; and, the second assay step (e), This step is to determine if the GHSR gene is highly methylated. In this embodiment, the diagnosis is based on the results of step (c) and step (e). In particular, the hypermethylation of the GHSR gene and the hypermethylation of at least one of the underlying genes indicate that the oral scraping sample is a neoplastic sample and that the individual has a stomatoma (ie, the individual may be benign Or malignant oral tumors).

In a fifteenth aspect, the invention relates to a method of determining whether an individual has osteosarcoma using a single osteosarcoma sample. According to various embodiments of the present disclosure, the sample used in step (a) is an osteosarcoma sample, and at least one of the target genes is ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I. , HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH or Z1C1; further, if at least one of the target genes is highly methylated, the individual is judged to have osteosarcoma.

According to an embodiment of the present disclosure as desired, the method further comprises a second methylation assay step (d), wherein the step is to determine a methylation status of the GHSR gene; and a second assay step (e), This step is to determine if the GHSR gene is highly methylated. In this embodiment, the diagnosis is performed in accordance with the results of step (c) and step (e). In particular, if the GHSR gene and at least one of the underlying genes are highly methylated, the individual is judged to have an osteosarcoma (ie, the individual may have a benign or malignant sarcoma).

In the following, a plurality of experimental examples are set forth to illustrate certain aspects of the present invention, and the present invention is not limited by the scope of the present invention. It is believed that the skilled artisan, after reading the description set forth herein, may fully utilize and practice the invention without undue interpretation. All publications cited herein are hereby incorporated by reference in their entirety.

Materials and Methods

Tissue sample

Volunteer subjects were recruited through the General Hospital of the Three Armies (Taipei, Taiwan, Republic of China) and their organizational samples were collected. During the period from 1994 to 2013, a total of 288 adult tissue samples were collected. The samples were obtained with the written consent of the patients and approved by the Trial General Hospital Human Test Committee.

Ovarian tumor samples were obtained surgically and immediately frozen in liquid nitrogen and stored in an environment of -80 °C. All clinical information in this experimental example is from the medical records of patients in the Three Military General Hospital. Pathological diagnosis was performed for each sample by a gynaecological and obstetric pathologist. The ovarian epithelial cells of the uterine fibroids were scraped to obtain normal epithelial ovarian tissue samples.

In the observation group (recovery cohort), there were 75 malignant ovarian tumor samples, 20 benign ovarian tumor samples, and 6 normal ovarian tissue samples. The above samples were from different patients, and these samples were used for wild-type whole-genome body armor. The study of the basic map. In the validation cohort, there were 118 malignant ovarian tumor samples, 43 benign ovarian tumor samples, and 8 normal ovarian tissue samples, all of which were from different patients. These samples were used here to verify differential A. Basic map.

Serum and plasma samples from patients with benign ovarian tumors (N=26) and malignant tumors (N=33), and serum and plasma samples from 18 women without ovarian tumors were collected. The collected blood samples were stored at -4 ° C; then, the serum and plasma in the blood samples were separated in three days and stored in a centrifuge tube and placed at -80 ° C until use.

Cervical scraping cells were collected from female patients with benign ovarian tumors (N=6) or malignant tumors (N=13) and without ovarian disease and cervical disease (N=25). The procedure for collecting the inner cervical scraping cells is as follows. Insert a new internal cervical sampling brush into the inner cervical canal, then gently rotate the collection brush three to five times to ensure that the sampling is true. Thereafter, the sample was placed in a centrifuge tube (15 ml) containing 2 ml of RNA later ® (Ambion; Life technologies; USA), and then the centrifuge tube was capped. The inner cervical scraping cell sample was stored at 4 °C. Thereafter, the cells were mixed for 10 seconds with an oscillator, and a swab cell-containing sample was evenly distributed into three centrifuge tubes (1 ml per tube), and stored at -80 ° C until use.

Cervical cancer (N=20), bladder cancer (N=20), hepatocellular carcinoma (N=24), breast cancer (N=15), colorectal cancer (N=15), endometrial cancer (N=15) Tissue samples such as oral cancer (N=15) and osteosarcoma (N=15) are the tissues remaining in the patient during the surgical procedure or pathological examination.

Normal (ie, non-cancerous) cervical epithelial scraping cells (N=24), normal bladder epithelial tissue (N=20) next to benign tumors, hepatitis tissue (N=24), normal breasts next to benign tumors Tissue (N=15), normal colorectal tissue next to benign tumor (N=15), endometrial hyperplasia (N=15), normal oral scraping cells (N=15) and osteoarthritic tissue (N=15) And other tissue samples were taken from patients who were not diagnosed with malignant tumors.

2. Preparation of genomic DNA and sulfite conversion

DNA was extracted from the samples using a QIAGENE ^® DNA extraction kit (purchased from Taigen Bioscience Corp; Taipei; Taiwan; Republic of China) and the DNA concentration was determined by a NanoDrop 1000 spectrophotometer. The pooled DNA sample used for the validation mixed five samples with the same amount of DNA and belonging to the same type of disease and tissue.

The genomic DNA (1 μg) was subjected to sulfite modification using a CpGenome Fast DNA modification kit (Chemicon-Millipore, MA, USA) and following the manufacturer's instruction manual, in which the genomic DNA was dissolved in 70 μl of no Nuclease in water. DNA methylation analysis was carried out using the above sulfite DNA as a template.

3. MethylCap sequencing

Two micrograms of genomic DNA was processed using the MethylMiner methylated DNA Enrichment Kit (Invitrogen, Carlsbad, CA) and following the manufacturer's manual to obtain methylated DNA. Briefly, genomic DNA was ultrasonicated to approximately 200-bp, captured as MBD protein, and precipitated using 1 M salt buffer. Based on the standard protocol provided by Illumina (San Diego, CA), a database of methylated DNA-producing databases is used for sequencing. The MethylCap-seq database was sequenced using the Illumina Genome Analyzer IIx System. Image analysis and base determination using the standardized Illumina pipeline. Special readings (to 36-bp readings) were incorporated into the human reference genome (up to two base pair pairing errors) using the ELAND algorithm.

4. Sulfite Pyrophosphate Sequencing

The degree of methylation of the CpG position of each pyrophosphate sequencing amplification of the DNA is quantified by sulfite pyrophosphate sequencing, wherein the degree of methylation is expressed as a percentage of methylation (eg, 0% to 100%).

The PCR product was amplified using a PyroMark PCR kit (QIAGEN). Samples, pyrophosphate sequencing, and analytical results were prepared using the PyroMark Q24 System (QIAGEN) and following the manufacturer's instruction manual.

The primers used for the sulfite pyrophosphate sequencing are shown in Table 1 below.

Table 1

5. Quantification of methylation-specificity polymerase chain reaction (qMSP)

In quantitative methylation-specificity PCR (qMSP), this experiment used a specificity probe and primer (Table 2) to identify the DNA methylation of the 3-8CpG position relative to the unmethylated (COL2A1) total input DNA. Degree. If the Cp value of COL2A1 is greater than 36, it is determined that the sample DNA is an unqualified sample.

Table 2

In the case of qMSP, fluorescence real-time PCR was performed using the Roche 480 PCR system. The reaction mixture (20 microliters) contained 2 microliters of sulfite genomic DNA, 250 nM primer (HPLC grade), 225 nM TaqMan probe, and 10 microliters of FastStart Universal probe Master (Rox) (Roche). The 5' end of the probe is labeled with 6-carboxy-fluorescein (6-FAM), while the 3' end is labeled with a quencher (MGB (Applied Biosystems) or BHQ1 (TIB). )mark. The reaction was carried out in a standard mode and a thermal cycle step, and the initial incubation temperature was 95 ° C for 10 minutes; then, DNA adhesion and elongation were carried out at 95 ° C, 15 seconds, and 60 ° C for 1 minute for 45 times. cycle.

6. Statistics

In the independent cohort, the true operating rate (ie, sensitivity) and the false positive rate (1 minus the difference in specificity) are plotted to obtain the receiver operating characteristic curve (ROC). . To assess the best accuracy, the area under the curve (AUC) was used to confirm the optimization threshold to distinguish between the two samples from the different groups. The best accuracy and threshold were evaluated using 100 times of shoe lift and the Youden method (maximum sum of sensitivity and specificity).

To assess the combination of the best candidate genes, a multi-regression model was used here to analyze the relationship between disease occurrence (positive (designated = 1) and negative (designated = 0)) and the degree of methylation of multiple genes. In the analytical model here, the correlation coefficient is used to indicate the degree of tightness between the methylation degree data and the ovarian tumor patients. When calculating the correlation coefficient, the square root of the measurement coefficient is taken. The higher the correlation coefficient, the higher the association of this gene combination with ovarian tumorigenesis. Correlation coefficients can also be used to calculate weighting values to calculate an optimization threshold for this combination of genes.

Variables are introduced into the regression model using the Enter mode and the Stepwise mode. In the forced selection method, all variables are forced to be entered into the model once. In the stepwise regression selection method, significant variables are sequentially input into the regression model; after inputting a variable, the p value of the variable is used to determine whether the variable is introduced into the regression model.

The Kruskal-Wallis test was used to assess the effect of several different ovarian tissue pathological types on the degree of methylation. A p value of less than 0.05 represents statistically significant.

Example 1

Identification of ovarian cancer diagnosis and prognosis and association with highly methylated genes

In the observation group, samples were analyzed by MethylCap sequencing, of which 29 candidate genes were associated with disease progression-free survival (PFS) and overall survival (OS) in individuals (see Table 3).

table 3

Further, 29 candidate genes in the observation group were further verified, in which normal ovarian tissue (N) and malignant ovarian cancer tissue (T) were used for sulfite pyrophosphate sequencing. The results showed that in the malignant ovarian cancer tissues, 21 candidate genes were significantly highly methylated (Fig. 1A and 1B).

Further studies were carried out with methylation profiles of 11 candidate genes. The results are shown in Figure 2. The methylation profiles of these 11 genes were associated with normal ovarian tissue (N, n=8), benign ovarian tumor tissues (B, n=43), and malignant ovarian cancer tissues (M, n=18). ), and this data has a significant difference (Kruskal-Wallis test; p < 0.001).

The 11 genes are ADCY8, CDO1, GHSR, HIST1H2BB, HIST1H3C, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2, and in the subsequent independent groups, the diagnostic and/or prognostic stratification ability of these genes was evaluated. Best accuracy.

Example 2

Using sulfite pyrophosphate sequencing to identify the best accuracy of normal ovarian tissue, benign ovarian tumor patients and malignant ovarian tumor patients

In the independent group, the ROC map was drawn; in addition, the cut-off point, AUC, and 95% confidence interval (CI) of the nine genes identified in Example 1 were measured, and the results are shown in Table 4. .

As can be seen from the data in Table 4, 9 of the 11 genes shown (ADCY8, CDO1, GHSR, HIST1H2BB, HIST1H3E, HTR1A, TRH, FOXI2, and MIR124-2) are useful for identifying normal ovarian tissue (N), benign Ovarian and malignant ovarian cancer tissues (B+M) exhibited significant accuracy (0.759 to 0.958).

Based on the stratified analysis between ovarian tumor tissue (B) patients and malignant ovarian cancer tissue (M) patients, 9 genes out of 11 genes (CDO1, GHSR, HIST1H3C, when using larger threshold points) HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2) exhibited significant accuracy (0.749 to 0.956).

Table 4

Example 3

use Evaluation of sulfite pyrophosphate sequencing to identify the best coefficient of normal ovarian tissue, benign ovarian tumor patients and malignant ovarian tumor patients

The highest five coefficients were evaluated by a multivariate regression analysis using a forced selection method; see Table 5.

From the data shown in Table 5, the correlation coefficients of genes such as MIR124-2, CDO1, HTR1A, GHSR and TRH were relatively different when distinguishing between normal ovarian tissue individuals (N) and benign or malignant cancer tissues (B+M). Higher.

On the other hand, the MIR124-2, CDO1, TRH, GHSR and FOXI2 genes showed better morphogenesis in normal ovarian tissue individuals (N), benign tumor tissue patients (B) or malignant ovarian cancer tissue patients (M). Correlation.

table 5

In view of this, CDO1, FOXI2, GHSR, HTR1A, MIR124-2 and TRH genes were further selected to investigate the stratification power of these genes on the qMSP platform.

Example 4

use qMSP Analysis of ovarian tissue from cervical scraping cells to assess the best combination of genes for identifying normal ovarian tissue, benign ovarian tumors, and malignant ovarian tumors

In this embodiment, the ovarian tissue sample is an ovarian tissue sample taken from the cervical scraping cell. The methylation profile was determined by qMSP and the normal ovarian tissue (N), benign or malignant ovarian cancer patients (B+M) were identified by stepwise multiple regression analysis.

From the results shown in Table 6, it is known that the combination of the GHSR and MIR124-2 genes can identify normal individuals (N) and individuals with benign or malignant ovarian cancer (B+M). The same combination of genes can also effectively identify benign ovarian tumor tissue (B) and malignant ovarian cancer tissue (M).

Table 6

Example 5

Cell free DNA gene

In this example, pooled cell-free DNA samples were taken from serum samples for qMSP analysis to distinguish between benign ovarian tumors (B) and malignant ovarian cancer (M). The preliminary data shown in Figure 3 shows that hypermethylation of candidate genes (FOXI2 and MIR24-2) in patients with malignant ovarian cancer occurs.

Example 6

Determination of histone plexus (Histone Cluster) Gene prognosis

In the validation cohort, ovarian tissue samples and sulfite pyrophosphate sequencing were used to study the prognostic ability of histone cluster genes (including HIST1H2BB, HIST1H3C, HIST1H3E, and HIST1H4I). These histone clump genes exhibit similar biological functions, namely, maintaining the stability of the chromosome structure and participating in the process of DNA replication. The results are shown in Figures 4A and 4B.

In Figure 4A, the above four histone plexus genes are highly methylated and are associated with poor prognosis (eg, shorter recurrence periods and lower PFS values during the same period; solid line). Next, based on the number of hypermethylation of histone cluster genes in the sample, individuals were divided into three groups: low HS-HM group (samples without or containing a highly methylated histone cluster gene); medium HS-HM group (samples containing two or three highly methylated histone cluster genes); and high HS-HM groups (samples containing four highly methylated histone cluster genes).

The data in Figure 4B shows that individuals in the HS-HM group (solid line) and the high HS-HM group (dashed line) have significantly worse survival outcomes. In addition, the survival curve (solid line) of individuals in the high HS-HM group was the worst.

Example 7

Threshold and univariate of multiple genes in ovarian cancer in the absence of disease progression COX regression analysis

Table 7

The histone proteome gene (including HIST1H2BB, HIST1H3C, HIST1H3E, and HIST1H4I) was used to predict the progression-free survival (PFS) of ovarian cancer patients. The ROC map obtained from the sulfite pyrophosphate sequencing data was used to generate histone cluster genes (including Hazard ratio (HR) and 95% confidence interval for HIST1H2BB, HIST1H3C, HIST1H3E, and HIST1H4I); the results are shown in Table 7.

The data in Table 7 shows that HIST1H3E is most effective in predicting PFS in patients with ovarian cancer ( p < 0.001).

The effect of histone cluster gene combination on the progression-free survival of ovarian cancer was studied by COX regression analysis. The results are summarized in Table 8.

Table 8

The data in Table 8 shows that the hypermethylation of the above histone cluster genes is significantly associated with ovarian cancer (high HS-HM group; adjusted HR = 10.45, p < 0.001). Furthermore, the medium HS-HM group and the high HS-HM group were associated with individual tumor recurrence. In addition, individuals in the high HS-HM group had the lowest risk (10.45 times) compared to individuals in the low HS-HM group.

COX regression analysis was used to study the effects of two hormone-associated genes (GSHR and TRH) on progression-free survival (PFS) in ovarian cancer. The results are shown in Table 9 and Figures 5A and 5B.

Table 9

As described in Table 9, hypermethylation of GSHR and TRH genes was an important factor in ovarian cancer (2-HM group; adjusted HR = 7.13, p = 0.012). Furthermore, in these two hormone-related genes, hypermethylation of one of the genes (1-HM group) or hypermethylation of two genes (2-HM group) is associated with the outcome of tumor recurrence in individuals ( See Figures 5A and 5B). In addition, individuals in the 2-HM group had a higher risk of recurrence (7.13 fold) compared to the group with no hypermethylation of both genes (0-HM group).

Table 10

The PFS probabilities for different patients are summarized in Table 10. This data is based on a highly methylated profile measured by different patients during the first and second years of treatment.

The data in Table 10 show that individuals with high HS-HM and 2-HM groups had the lowest proportion of individuals with no recurrence during the first year after treatment, at 28.6% and 56.7%, respectively, while the proportion of no recurrence during the two years was 14.4. % and 30.9%.

Example 8

Methylation map of candidate genes in different tissues

For the 21 candidate genes shown in Example 1, they were measured in different tissues (including bladder (Bl), breast (Br), large intestine (Cl), cervical (Cx), endometrium (Em), and liver (Hepa). Methylation profiles in the oral (Oral) and sarcoma (SA) tissues. The results are shown in Figures 6A, 6B and 6C.

Example 9

Evaluate the best accuracy for identifying patients with normal bladder tissue, benign or malignant bladder tumors

Table 11

In the present example and the following examples, the ROC map was drawn using the methylation map obtained in Example 8. Next, the threshold points, AUC, and 95% confidence interval (CI) of the 21 candidate genes were measured, and the results are shown in Table 11.

The results in Table 11 show that ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, GHSR, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PRDM14, RAX, SPAG6 and TRH genes can be used to identify normal cystic tissue (N) An effective marker for an individual, a subject with benign or malignant bladder tumor tissue (B+M).

Example 10

Evaluate the best accuracy for identifying normal breast tissue individuals and benign or malignant breast tumors

Table 12

In this embodiment, the optimal threshold for determining the individual breast tissue individual (N) and the benign or malignant breast tumor tissue individual (B+M) for each candidate gene, and the sensitivity and specificity of each candidate gene threshold are determined. degree. The results are shown in Table 12.

The results in Table 12 show that ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H3C, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6 and TRH genes can be used to identify normal breast tissue. Individual (N) and a valid marker with a benign or malignant breast individual (B+M).

Example 11

Assessing the best accuracy of identifying normal ovarian tissue individuals with benign or malignant cervical tumors using cervical scraping cells

Table 13

Effective markers were determined by cervical scraping to distinguish whether the individual had a cervical tumor, and the data is summarized in Table 13.

The results in Table 13 show that ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, GHSR, HIST12BB, HIST1H3C, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and ZIC1 genes As an effective marker for identifying normal cervical tissue individuals (N) and individuals with benign or malignant cervical tumor tissue (B+M).

Example 12

Evaluate the best accuracy for identifying individuals with normal colorectal tissue and individuals with benign or malignant colorectal tumors

Effective markers were determined by large intestine tissue samples to distinguish individuals from colorectal tumors, and the data are summarized in Table 14.

Table 14

The results in Table 14 show that ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H3C, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PRDM14, RAX, SPAG6 and TRH genes can be used to identify normal colorectal tissues (N And an effective marker with a benign or malignant colorectal tumor tissue individual (B+M).

Example 13

Assessing the best accuracy for identifying individuals with normal endometrial tissue and with benign or malignant endometrial tumors

Effective markers were determined by taking samples from endometrial cells to distinguish whether the individual had an endometrium, the data is summarized in Table 15.

Table 15

The results in Table 15 show that CDH8, ECEL1P2, FOXI2, GHSR, HIST1H3C, HIST1H4I, HTR1A, and TRH genes can be used to identify normal endometrial tissue (N) and benign when tested from endometrial cells. Or a valid marker for a malignant endometrial tumor tissue individual (B+M).

The effective marker can be determined by taking samples from the cervical scraping cells to effectively distinguish whether the individual has endometrioma. The data are summarized in Table 16.

The results in Table 16 show that PRDM14, GHSR, TRH, FOXI2, Z1C1, and MIR124-2 genes can be used as markers to identify normal endometrial tissue (N) and when using samples taken from cervical scraping cells. A valid marker for benign or malignant endometrial tumor tissue individuals (B+M).

Table 16

Further verify the degree of methylation of CDO1 in endometrial cancer patients (EC) and healthy individual tissues. The data is summarized in Figure 7A and the results show that the DNA methylation status of CDO1 in endometrial cancer is higher than in endometrial and fibroids (n = total number of cases). Figure 7B is a graph showing that in order to distinguish endometrial cancer patients (EC) from healthy individuals, the methylation of CDO1 is 0.94 at 1 AUC, the sensitivity (Sn.) is 77.4%, and the specificity (Sp.) is 96.9. %.

Example 14

Assess the best accuracy in identifying normal liver tissue individuals and benign or malignant liver tumors

Effective markers were determined by taking samples from liver tissue to distinguish whether the individual had a liver tumor, and the data is summarized in Table 17.

Table 17

The results in Table 17 show that ADCY8, C17orf46, CDH8, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and ZIC1 genes can be used to identify normal liver tissue individuals (N And an effective marker with a benign or malignant hepatocyte tumor tissue individual (B+M).

Example 15

Evaluate the use of oral scraping cells to identify normal oral tissue and the best accuracy with benign or malignant oral tumors

Effective markers were determined by taking samples from the oral scraping cells to distinguish whether the individual had a oral cavity, as summarized in Table 18.

The results in Table 18 show that the CDH8, COL14A1, DPP6, ECEL1P2, FOXI2, and HIST1H3E genes can be used as markers for identifying normal oral tissue individuals (N) and individuals with benign or malignant oral tumor tissue (B+M).

Table 18

Example 16

Assessing the use of normal osteosarcoma to identify individuals with normal osteosarcoma and with benign or malignant osteosarcoma ( Osteosarcoma Neoplasm ) Optimum accuracy

Effective markers were determined by taking samples from osteosarcoma cells to distinguish whether the individual had osteosarcoma, as summarized in Table 19.

The results in Table 19 show that ADCY8, C17orf46, CDO1, COL14A1, ECEL1P2, FOXI2, HIST1H3C, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH and ZIC1 genes can be used to identify normal chondrocytes (N And an effective marker with a benign or malignant osteosarcoma tissue individual (B+M).

Table 19

Although the embodiments of the present invention are disclosed in the above embodiments, the present invention is not intended to limit the invention, and the present invention may be practiced without departing from the spirit and scope of the invention. Various changes and modifications may be made thereto, and the scope of the invention is defined by the scope of the appended claims.

no

The above and other objects, features, advantages and embodiments of the present invention will become more <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; The degree of methylation of a candidate gene and a control gene; FIG. 2 is a methylation profile of 11 candidate genes in an ovarian tissue sample according to an embodiment of the present disclosure; FIG. 3 is a hybrid according to an embodiment of the present disclosure. Methylation index of 2 candidate genes in a cell-free DNA sample; the line graphs of Figures 4A and 4B show the prognostic ability of four histone plexus genes in ovarian tissue samples according to an embodiment of the present disclosure; Figures 5A and 5B The line graph shows the prognostic ability of the TRH gene, the GHSR gene, and the binding digene in an ovarian tissue sample according to an embodiment of the present disclosure; FIGS. 6A, 6B, and 6C are summarized in accordance with an embodiment of the present disclosure, in different tissue samples. Methylation index of 21 candidate genes and a control gene; and Figures 7A and 7B are in a tissue and cervical scraping sample according to an embodiment of the present disclosure Methylation profile and sensitivity of CDO1.

<110> Taipei Medical University Jinyun <120> Methods for cancer diagnosis and prognosis <130> P2795-TW <150> US62/103539 <151> 2015-01-14 <160> 102 <170> BiSSAP 1. 3     <210>   1   <211>   twenty four   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ADCY8_ forward primer     <400>   1   Tttgggttta   Ggttttttgg   Ttga   twenty four       <210>   2   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ADCY8_ reverse primer     <400>   2   Cccctcctcc   Tccttcttt   19       <210>   3   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ADCY8_pyrophosphate sequencing primer     <400>   3   Gttttggttg   Ttgtattgg   19       <210>   4   <211>   25   <212>   DNA   <213>   Artificial sequence     <220>   <223>   C17orf46_ positive introduction     <400>   4   Gggtgtaagt   Tttgtttagt   Atagt   25       <210>   5   <211>   30   <212>   DNA   <213>   Artificial sequence     <220>   <223>   C17orf46_ reverse primer     <400>   5   Aatactacct   Ctccccctcc   Aatatactct   30       <210>   6   <211>   15   <212>   DNA   <213>   Artificial sequence     <220>   <223>   C17orf46_pyrophosphate sequencing primer     <400>   6   Ggagaggaag   Gagtt   15       <210>   7   <211>   twenty three   <212>   DNA   <213>   Artificial sequence     <220>   <223>   CDH8_ forward primer     <400>   7   Gggagggggg   Attgtttata   Tga   twenty three       <210>   8   <211>   29   <212>   DNA   <213>   Artificial sequence     <220>   <223>   CDH8_ reverse primer     <400>   8   Atccccaacc   Caaaatacaa   Ctaatatct   29       <210>   9   <211>   twenty two   <212>   DNA   <213>   Artificial sequence     <220>   <223>   CDH8_pyrophosphate sequencing primer     <400>   9   Cccaaaatac   Aactaatatc   Tt   twenty two       <210>   10   <211>   18   <212>   DNA   <213>   Artificial sequence     <220>   <223>   CDO1_ forward primer     <400>   10   Aggtggagag   Gggagagg   18       <210>   11   <211>   25   <212>   DNA   <213>   Artificial sequence     <220>   <223>   CDO1_ reverse primer     <400>   11   Tcatcctccc   Caaccccttt   Taaac   25       <210>   12   <211>   15   <212>   DNA   <213>   Artificial sequence     <220>   <223>   CDO1_pyrophosphate sequencing primer     <400>   12   Aaagtggggg   Agaga   15       <210>   13   <211>   twenty three   <212>   DNA   <213>   Artificial sequence     <220>   <223>   COL14A1_ positive primer   Sequence     <400>   13   Atttgtgttg   Ggtaaggttt   Tag   twenty three       <210>   14   <211>   twenty three   <212>   DNA   <213>   Artificial sequence     <220>   <223>   COL14A1_ reverse primer     <400>   14   Accttccttt   Cctcttatct   Aat   twenty three       <210>   15   <211>   25   <212>   DNA   <213>   Artificial sequence     <220>   <223>   COL14A1_pyrophosphate sequencing primer     <400>   15   Ggagttttta   Gagtttaggt   Aagat   25       <210>   16   <211>   18   <212>   DNA   <213>   Artificial sequence     <220>   <223>   DPP6_ forward primer     <400>   16   Aggaggtagg   Tggggaag   18       <210>   17   <211>   30   <212>   DNA   <213>   Artificial sequence     <220>   <223>   DPP6_ reverse primer     <400>   17   Aacccaaact   Ctaactatac   Tttctctctt   30       <210>   18   <211>   18   <212>   DNA   <213>   Artificial sequence     <220>   <223>   DPP6_pyrophosphate sequencing primer     <400>   18   Cccaaaattt   Aacaccac   18       <210>   19   <211>   27   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ECEL1P2_ forward primer     <400>   19   Attttggagg   Tttagttggt   Gtttaag   27       <210>   20   <211>   twenty one   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ECEL1P2_ reverse primer     <400>   20   Acaaccttca   Aaacaaactc   c   twenty one       <210>   twenty one   <211>   16   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ECEL1P2_pyrophosphate sequencing primer     <400>   twenty one   Gggttgtagt   Tttgga   16       <210>   twenty two   <211>   twenty one   <212>   DNA   <213>   Artificial sequence     <220>   <223>   FOXI2_ forward primer     <400>   twenty two   Atagttttgg   Gggttttgag   g   twenty one       <210>   twenty three   <211>   twenty two   <212>   DNA   <213>   Artificial sequence     <220>   <223>   FOXI2_ reverse primer     <400>   twenty three   Ctctaattcc   Cccttcctcc   Tt   twenty two       <210>   twenty four   <211>   20   <212>   DNA   <213>   Artificial sequence     <220>   <223>   FOXI2_pyrophosphate sequencing primer     <400>   twenty four   Ggatttaggg   Tttttgtaat   20       <210>   25   <211>   25   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GHSR_ positive primer     <400>   25   Tttgggaagt   Gagagatgga   Attgg   25       <210>   26   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GHSR_ reverse primer     <400>   26   Tctaacacct   Cccctttcc   19       <210>   27   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GHSR_pyrophosphate sequencing primer     <400>   27   Gtgagagatg   Gaattggat   19       <210>   28   <211>   27   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H2BB_ forward primer     <400>   28   Aaattgtaag   Gttgtaatag   Gaagtta   27       <210>   29   <211>   26   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H2BB_ reverse primer     <400>   29   Aacactctcc   Actacaaaat   Aataca   26       <210>   30   <211>   25   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H2BB_pyrophosphate sequencing primer     <400>   30   Aaaacccata   Tatttataat   Cttaa   25       <210>   31   <211>   30   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H3C_ forward primer     <400>   31   Gagagtaagt   Ggtttttaaa   Tatagtgaga   30       <210>   32   <211>   27   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H3C_ reverse primer     <400>   32   Aataaaccaa   Tcaatctaat   Cactctt   27       <210>   33   <211>   twenty four   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H3C_pyrophosphate sequencing primer     <400>   33   Tggttttgta   Atattttaaa   Agtt   twenty four       <210>   34   <211>   27   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H3E_ forward primer     <400>   34   Gtttggtgag   Galaatagtt   Taggatt   27       <210>   35   <211>   27   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H3E_ reverse primer     <400>   35   Aatatcctcc   Aaaaacccca   Ccaaata   27       <210>   36   <211>   twenty three   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H3E_pyrophosphate sequencing primer     <400>   36   Gagaaatagt   Ttaggatttt   Aag   twenty three       <210>   37   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HISTIH4I_ forward primer     <400>   37   Aaaggaggta   Agggtttgg   19       <210>   38   <211>   30   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HISTIH4I_ reverse primer     <400>   38   Aataactaaa   Cttcaaaata   Ccatttaacc   30       <210>   39   <211>   16   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HISTIH4I_pyrophosphate sequencing primer     <400>   39   Aaggtgtttt   Tggaga   16       <210>   40   <211>   twenty two   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HTR1A_ forward primer     <400>   40   Gttgggagtg   Gagagtaagg   Tt   twenty two       <210>   41   <211>   29   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HTR1A_ reverse primer     <400>   41   Accaacctcc   Ctaaacaaaa   Acaaatact   29       <210>   42   <211>   15   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HTR1A_pyrophosphate sequencing primer     <400>   42   Gagagtaagg   Ttggg   15       <210>   43   <211>   28   <212>   DNA   <213>   Artificial sequence     <220>   <223>   MIR124-2_ forward primer     <400>   43   Gtttttagtt   Ttagattgtg   Gttattgg   28       <210>   44   <211>   28   <212>   DNA   <213>   Artificial sequence     <220>   <223>   MIR124-2_ reverse primer     <400>   44   Aattaactca   Tccccaccta   Cctaatcc   28       <210>   45   <211>   17   <212>   DNA   <213>   Artificial sequence     <220>   <223>   MIR124-2_pyrophosphate sequencing primer     <400>   45   Tggttattgg   Ttgagga   17       <210>   46   <211>   26   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PCDHGA5_ forward primer     <400>   46   Atatagagaa   Aattgggtag   Agagaa   26       <210>   47   <211>   twenty two   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PCDHGA5_ reverse primer     <400>   47   Actccaaccc   Aaaatcctta   Ac   twenty two       <210>   48   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PCDHGA5_pyrophosphate sequencing primer     <400>   48   Aaaaaacctt   Tatccaact   19       <210>   49   <211>   twenty one   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PRDM14_ forward primer     <400>   49   Taggtagggg   Gtgaggttgt   a   twenty one       <210>   50   <211>   28   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PRDM14_ reverse primer     <400>   50   Aaacccttaa   Ttccattcac   Attcacaa   28       <210>   51   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PRDM14_pyrophosphate sequencing primer     <400>   51   Ggtaggagag   Gaatttgtt   19       <210>   52   <211>   twenty four   <212>   DNA   <213>   Artificial sequence     <220>   <223>   RAX_ forward primer     <400>   52   Gggagaaggt   Ttttttttag   Ttag   twenty four       <210>   53   <211>   18   <212>   DNA   <213>   Artificial sequence     <220>   <223>   RAX_ reverse primer     <400>   53   Cccaccccaa   Aaccattt   18       <210>   54   <211>   twenty one   <212>   DNA   <213>   Artificial sequence     <220>   <223>   RAX_pyrophosphate sequencing primer     <400>   54   Agttagtttt   Gggttatttt   t   twenty one       <210>   55   <211>   twenty two   <212>   DNA   <213>   Artificial sequence     <220>   <223>   SPAG6_ forward primer     <400>   55   Gggggagtta   Tgagttagag   Gt   twenty two       <210>   56   <211>   29   <212>   DNA   <213>   Artificial sequence     <220>   <223>   SPAG6_ reverse primer     <400>   56   Ccacattta   Caccaactaa   Atcctaacc   29       <210>   57   <211>   15   <212>   DNA   <213>   Artificial sequence     <220>   <223>   SPAG6_pyrophosphate sequencing primer     <400>   57   Gttgtaaggt   Agggt   15       <210>   58   <211>   28   <212>   DNA   <213>   Artificial sequence     <220>   <223>   TRH_ forward primer     <400>   58   Ggggttttta   Gagttgtaga   Tttttgat   28       <210>   59   <211>   twenty three   <212>   DNA   <213>   Artificial sequence     <220>   <223>   TRH_reverse primer     <400>   59   Aaaaaactcc   Ctttccaata   Ctc   twenty three       <210>   60   <211>   twenty three   <212>   DNA   <213>   Artificial sequence     <220>   <223>   TRH_pyrophosphate sequencing primer     <400>   60   Aaaataaact   Ccacaaaata   Aat   twenty three       <210>   61   <211>   26   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ZIC1_ positive primer     <400>   61   Gttgaatagg   Gatattttgg   Aagtgt   26       <210>   62   <211>   27   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ZIC1_ reverse primer     <400>   62   Acttttcctt   Ctcacaatca   Tatacat   27       <210>   63   <211>   25   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ZIC1_pyrophosphate sequencing primer     <400>   63   Tttttgttgt   Gtttattagt   Tttat   25       <210>   64   <211>   30   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GRHL2_ forward primer     <400>   64   Ttggtgaaat   Tggattttta   Agtttgtgta   30       <210>   65   <211>   twenty three   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GRHL2_ reverse primer     <400>   65   Atataaaaaa   Ccccccctta   Tcc   twenty three       <210>   66   <211>   15   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GRHL2_pyrophosphate sequencing primer     <400>   66   Taggtgaagg   Tgtgt   15       <210>   67   <211>   twenty three   <212>   DNA   <213>   Artificial sequence     <220>   <223>   FOXI2_MS02_ positive primer     <400>   67   Ggttgcgggg   Ttcgtgaagt   Tag   twenty three       <210>   68   <211>   20   <212>   DNA   <213>   Artificial sequence     <220>   <223>   FOXI2_MS02_ reverse primer     <400>   68   Ccccgcccaa   Acctaacacg   20       <210>   69   <211>   29   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GHSR_MS02_ positive primer     <400>   69   Atttttattt   Tcgggtgtga   Tttgttttt   29       <210>   70   <211>   25   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GHSR_MS02_ reverse primer     <400>   70   Cgaataaaaa   Ccgcaaaaac   Caaac   25       <210>   71   <211>   31   <212>   DNA   <213>   Artificial sequence     <220>   <223>   MIR124-2_MS01_ positive primer     <400>   71   Aagattagag   Gttttgtttt   Tcgtgtttat   a   31       <210>   72   <211>   27   <212>   DNA   <213>   Artificial sequence     <220>   <223>   MIR124-2_MS01_ reverse primer     <400>   72   Atatccttca   Aatacaaccg   Taaactc   27       <210>   73   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   TRH_MS03_ positive primer     <400>   73   Ccaatactcc   Cgaacaccg   19       <210>   74   <211>   19   <212>   DNA   <213>   Artificial sequence     <220>   <223>   TRH_MS03_ reverse primer     <400>   74   Gattgcggat   Ttcgagttt   19       <210>   75   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   TMEM132D     <400>   75   Ttttctgaac   Atgctgggag   Ttaactgtct   Ttgctctgca   Actgttaccc   Gcacaacttt   60     Aataacaagt   Ctagagcttc   Cggaggctgc   Tacgtagaat   Gggctgtccg   Agaatgaaga   120     Caaataggca   Aatatagagg   Aaaacagaga   Gaggagaaga   Gacagggagc   Ccctgggcca   180     Accatccggg   Atggatgttg   Gatgcactgc   Tgcttgttcc   Atcctagaaa   Gtaacacatc   240     Ctcttcctca   Ctcctgctat   Ttttccctta   Agcccacttt   Attttttcaa   Tcacttgcaa   300     Taaaaggatt   Ctctttaaag   Caaacaggaa   Gacagaactt   Cttctctgcc   Atggggactt   360     Ctttttccct   Ggagtggatg   Ggaatgtgcc   Ccccaggaag   Atatgttgaa   Gtcttacccc   420     Ttaatccctg   Tgaatgtgac   Cttatctgga   Aatagggtct   Ttgcagatgt   Aatcaaggta   480     Agatgaggtc   Atatgaatta   Gggtatatcc   Aaaatccagc   Gactgaatgt   Cttaagaaaa   540     Cttggacaca   Aagactcgca   Gggagaggac   Cgtgcgatga   Cagaggcagg   Gggtagagtg   600     Atgtatccac   Cagccaggag   Accccagatt   Gtcgcgagcc   Accggaagct   Ggaagaggag   660     Gcatggggct   Gatttggcct   Cataacacct   Ggaaggaacc   Acctctgccg   Acacctcgac   720     Tttggacttt   Ctgccttcag   Aatggtgaga   Gaataaattt   Cggttgctgt   Gagcagccct   780     Gtttgcagtg   Atttgttatg   Acggccccag   Gaaaccaata   Catctcccaa   Aacacatgca   840     Gcctttgtac   Ccaggacaga   Ccctgcattc   Tcctctctct   Gactttctga   Tgaacagatc   900     Agcatgtttt   Cccatatact   Catatcgttt   Ggggtcagat   Gtggggaagg   Cgtgtcacag   960     Tgtgcttgag   Aagaaggacc   Tgttggccag   Gcagagattc   Ctccgatcca   Agtcactact   1020     Gcatcgggcc   Tctggcctgt   Cgcccttctc   Gcctctgcct   Cccctctcca   Ccccctggat   1080     Cagtcatcca   Cagtaatcac   Tggctcagag   Gatgccagtc   Tccactgggg   Gaccccccg   1140     Acccatccgt   Cttcctgcca   Gagcatcatt   Tgctgctgca   Agggcaaaac   Aaagggggg   1200     Aaggagctaa   Tgactgcacc   Ttgggaagcg   Ccagttgggt   Aattaattca   Cagttctgag   1260     Ctttcccaga   Aggaaaaaga   Taaattgttc   Acttgcactc   Ccagggtgtc   Ctagcagaga   1320     Ctcatttgta   Aaacgggtgt   Gaaaccgagg   Gtagggcgag   Gctctgaggg   Atgagatgca   1380     Ttcctggaag   Gccagtgggc   Cccaccagcc   Cagtgccagg   Gcagtcacaa   Ctggctgccc   1440     Tcggcttgtg   Cacaggctta   Gctgcccagg   Accttaggac   Cagaggctgg   Tgttacggat   1500     Tgaactgtgt   Ctcccccgac   Cccaaattca   Ttagggaaat   Cctaatgccc   Agtatcagag   1560     Gacaatcttg   Tatggaaata   Gggtcattgc   Agatgtaatt   Agttgagatg   Aggtcatact   1620     Ggagtagagt   Gggccctggc   Ttccttgggg   Aaatttggag   Ccgggcatgg   Tggcttatcc   1680     Tgtaatccca   Gcactttggg   Aggccaaggc   Gggatgattg   Cttgagggca   Ggagttcgag   1740     Accagcctgg   Gcaacatagt   Gagaccccat   Atttacaaaa   Aattttaaaa   Attagctagg   1800     Tgtggtggtg   Tgtggctgta   Gtcccagcta   Cttgagaggc   Tagggtggga   Ggattgcttg   1860     Agcccaggag   Gtcgaggcag   Cagtgagcgt   Tgatcacaca   Actgtattcc   Agcctgggta   1920     Gcaaagtgag   Atccctgtct   Cacaaaaaag   Aagaaattcg   Gacacagaca   Cacacacagg   1980     Gagtctgtca   Catgaagacg   Aaggcagaga   Tcagagtgat   Gcttctacaa   Gccaaggact   2040     Accaagatgc   Cagcaaccgc   Aggagctggg   Agaggcctgg   Aggagttccc   Ccacaaaccc   2100     Tccgagggaa   Ccagctctgc   Cgacacgctg   Agctcagact   Tcaggcttcc   Agaaaagtga   2160     Agcaatacat   Ttctgttatt   Aaagctgccc   Agtttgtggt   Atttagttag   Tttaggtaaa   2220     Gtacctgtag   Ccggagtcca   Gggagggaac   Tgagaagccg   Cgagggacag   Gcccccaacg   2280     Gagatgctga   Tgaggccggc   Agccttccag   Cttccagcgc   Catcttcctt   Gggagtttgg   2340     Gaaactcagt   Gcctccaggg   Gccccgcagg   Tggcgtcaaa   Gagcgaacca   Gccaggtgca   2400     Agagaaacca   Agccgcatca   Cttatttatt   Cacactcgaa   Aagacacctc   Gtggacattt   2460     Cagttaagac   Tttcctatca   Gttctttctc   Agattctggg   Cacatagatc   Gcatgacggt   2520     Ttgcatcata   Atggcgtctt   Cagttgtgtt   Ctttagacat   Gacattctat   Atttgcctag   2580     Gagacacaca   Ggatttttct   Tcccttttgt   Aaagcaatga   Gctctttctg   Aatgatcttg   2640     Aaaacacac   Gctccttccc   Tctctgtttc   Ccccactttt   Gggtagagct   Gtgacttggg   2700     Agaaacactt   Ctgtattaga   Agaggtgga   Gagggagcat   Aaatggagtt   Ggtcaactct   2760     Gggtccagaa   Gacatcgtgg   Gtggagagga   Ctcgaaacct   Cagtgccact   Ctgccccatc   2820     Gaggccaagt   Cagattggaa   Gccccatttt   Gccagtgtct   Gaattcttaa   Gcgatgctag   2880     Aaatctagat   Ttctaaggtg   Aaatcatcaa   Agttttgaat   Gttggctcaa   Ttttctccat   2940     Tctgcaacca   Gtttcattgt   Cttttacaaa   Acttatgact   Ggctgggttc   Cgtggctcac   3000     Acctgtaatc   Ccaggacttt   Gggaggccga   Ggtgggagga   Ttgcttgagc   Ccaggagttc   3060     Aagatcagcc   Tgggcaacat   Agcaagaccc   Ccatatctac   Aaaaagtaca   Aaaattcact   3120     Gagtgtggtg   Gcatgttcct   Gtagtcccag   Ctactcggga   Ggctgaggtt   Gggaggatca   3180     Cttgagcact   Caggaggcag   Aggttttagt   Gagctgagat   Tgtgccactg   Cgctccagcc   3240     Tgggcaacaa   Gacagagcaa   Gaccctgtct   Caaagcaaaa   Acaaacaaac   Aaaaaaaccc   3300     Atgactatct   Gaaattattt   Tgtttgctgt   Tttatccccc   Tacccaaata   Gatataagta   3360     Aggttttgga   Gagtgcatgt   Gcatttgctg   Tatgtgtgac   Tctgtctcta   Gtgctcacag   3420     Ctattcctgc   Tacagagtag   Agtagctgct   Cagtaaatac   Tggctgaata   Aatgattgac   3480     Ctatcaatca   Cttgctattg   Tttgcatgaa   Tataaggatt   Ccatgcatct   Tcttgtttcg   3540     Tagaattgtc   Ttggggctgc   Agttgataaa   Ggaatctaca   Atcaactttt   Taacccagtc   3600     Cagagttgtt   Gtatgtacac   Tcgagaccca   Aaggaaggac   Agagaatttt   Cctcacctca   3660     Gcccaaaagg   Aggctggaat   Gcatgcttgc   Ctgccacagt   Ttccacttac   Ttccaccat   3720     Cagtcagcag   Gcttttagga   Gagaattgca   Cgtgtgattt   Atttgcaaat   Cctttcaggt   3780     Cctggaggag   Agatacttgg   Tacacaatgc   Actttgtcat   Cacgtgtcaa   Catcccctca   3840     Atgcagggag   Cagcactaca   Cgatgtaaag   Gtggaactgg   Attgtgctgg   Gatccttcaa   3900     Tcagcatttc   Atttagagct   Gcagcatttg   Cagagccatt   Tgcaattgat   Gccagcccct   3960     Tggagggggt   Cagcgtgtag   Aagacaaagg   Acagccataa   Agccactgaa   Tgcaaacttt   4020     Atatttacag   Tcagtaagtt   Tataaatata   Tattacattc   Ttacaatcta   Cagtacattc   4080     Tacacgcaga   Tggatttgga   Agcgggcagc   Ggctgcagta   Ttcaacagaa   Catgacacag   4140     Gtaagaatgg   Aaagaaatat   Gaggacgtta   Ctgaaagcaa   Aggattctca   Ttgaaaaggg   4200     Gtgacagctt   Aatcacccaa   Ccaaacaagg   Taggtaagct   Tgcggacagg   Agcaggtgac   4260     Ttactggctg   Cagaaacctc   Agtctcaaga   Gcaccacagt   Tgcaggggag   Agggctaagg   4320     Ttgggagggt   Aaactggtga   Aatttacaca   Cacatgatct   Aaagagaatt   Caattctatg   4380     Gagaggaaga   Aggagtaaag   Acacacactc   Aaaattacag   Agatgagatg   Gagaggaagc   4440     Agggagaaga   Taggttcaaa   Ggaggagaga   Gatacagaga   Cagacacaca   Gagagactgg   4500     Aaaacagaca   Actgaagagc   Agagagagag   Agaaaatgac   Cagagggaaa   Aatagaagat   4560     Caattcaaca   Gcacggcctc   Ttctgcccac   Cacccgctgc   Ccccgaccat   Cttttgcagg   4620     Atcctatctg   Gctggcaatc   Acccaacaca   Ccattctcta   Cctgtgagtg   Agcgtgagat   4680     Gaggcaggaa   Ttctctgatg   Tatccttgcc   Cccatcttca   Taggcttcat   Aagtgaaggg   4740     Attcagggat   Atccagagtc   Atggctggtc   Ttaagcaatg   Ctgaaccttt   Cggggctgac   4800     Tgcaggacca   Agtgcttgca   Aacctgcatc   Ttcaccacat   Gcactgatgc   Cccttatccc   4860     Ttcgcacctc   Caagatgaag   Aaggtttctg   Tgctgtccgg   Tgtgtgtgag   Gctgggcttc   4920     Ctgctggatc   Caccactttc   Acacccagaa   Cccccccaac   Tccacacgcc   Ctgcacgttc   4980     Cacacaggca   Cccggatttg   Tctcaacagc   Ctcgaggcca   Catctttgga   Caggagatct   5040     Gccatgaaca   Gtgaaagacc   Catcccaagt   Ggccctgttt   Tctttctagt   Aaagcaaggg   5100     Aatgtatatc   Ccctggtatg   Gaattcaccg   Tgactaccgc   Ccatgcctag   Agaccagcct   5160     Cttcaaagac   Ggacggcgtg   Ggacatatgc   Ccaggttgcg   Gggggagctt   Ctctacagaa   5220     Tgtcacttgg   Gagttgacac   Aaaacccagg   Gggagaaaaa   Agaccagca   Aatactacaa   5280     Actgccctct   Ccctccccca   Cccacaggtg   Accaacggct   Ttggggagga   Tggcaatgca   5340     Gtggaggaat   Gagaatggat   Acattgtgaa   Cttgatatga   Atcaaaagag   Cgtggttctt   5400     Tgaacctgat   Tcaaattcta   Tgcccagtat   Ccttagttta   Caaataaaga   Agtacccga   5460     Agggctcaga   Ggatttgcgt   Ccatgtgttt   Gtccttggca   Tgtagttaca   Aaggtattg   5520     Tggcctgtta   Gcccacatgt   Tccctttcag   Tccttgtcag   Ccacttcctt   Ggcctgtcca   5580     Tgatctgaga   Cagctctggc   Ccaggctttg   Agagacaatg   Actcacaatc   Atgcctccca   5640     Cagctgacgg   Cggcactgga   Ctgcctgtga   Tcgcgctcac   Agcaagatgt   Gctgctccag   5700     Tttcgatgac   Acgcttcctc   Ccattgatcc   Atggatgcga   Tccatggatg   Ctccacctga   5760     Gttgtacttt   Tcttccatag   Tctgcaatat   Tgaatattgg   Agccatgtgg   Attttacaat   5820     Atccaaattg   Ctttgattcg   Agagagagag   Gctgttcttt   Cctggacgct   Ctcagacgct   5880     Cagtgattca   Gaactcgttt   Ttgtttcaag   Tcttaaaaat   Cttgccatgc   Atgataaacc   5940     Tcttaagcaa   Gacactgtac   Tctggaatgt   Gtgcgtcgat   Gcggactcca   Ggcctcgccg   6000     Ccgagccggg   Gtcattggct   Gaggctgtat   Ggatagtgtc   Atccttattt   Tgtcctgctg   6060     Ctttgtttct   Cttccggggg   Caccgttgct   Acacatcctg   Gaattaaagg   Ctgaaaggtg   6120     Agtgagaacc   Aatgtctgtg   Tgtgtctggc   Ttacacattt   Tcatgtaacc   Tctccatgta   6180     Gttgtgcagc   Tctttgcagt   Ccccagggtc   Cagatcctgg   Cagacccact   Taatgtcatc   6240     Ctcgctactc   Atcacgatgg   Agttcctggt   Ggggtactcg   Tcgtctgagg   Agacggcggt   6300     Gaaggtggta   Aattttaccc   Ttttcctttt   Tgaggtaggg   Gatgttgggg   Gctcactttt   6360     Ctgatctttc   Ccatcaatga   Tgatgggtcc   Caaaggtttg   Aacagctgcc   Cattgatgct   6420     Tttttgggag   Tttgtgctga   Ggagatattt   Actttcctcg   Aaatccatgc   Ccctgtcaat   6480     Ggcagtgatt   Tgctcatctt   Gcgaggaggc   Aaagttgatg   Tgattctcca   Acagctctgt   6540     Ccggttgctt   Aacccaaccc   Agtcatgaga   Gtgactcatc   Ccttcctgct   Cctcgaaggg   6600     Aacctgtttg   Tgtctgtatt   Tatagtcacaa   Ggtcacacag   Tttatcaaga   Agaccaaaat   6660     Ggccaaacag   Aagactccca   Acaaagcata   Catcccaatt   Tctaagtcgc   Tcagcccttt   6720     Gtaggcctgc   Atagagtcat   Tcccatccat   Ttccccattg   Cttctgggga   Ggtccacctg   6780     Ggctgggaag   Ctggtgaggt   Cgctggggat   Ggtctgcaag   Tggctgttgt   Catctaaaag   6840     Gctttcctgg   Cctttcttct   Tctgcaggat   Ggacctgtct   Gtcgtggtgc   Cccgtccctc   6900     Catgagtccc   Atagaagaac   Tgccatagta   Ctgtccttcc   Tgactccccc   Attcctgcga   6960     Gggttttttg   Ggccttctgt   Cactgacatt   Gttttccatg   Tgaacccctg   Cccctgtgtg   7020     Tctgctgtca   Ctggtgttgg   Ggttagcatc   Gttttggcca   Aatttaactt   Tgatgtttgc   7080     Cgttccaaca   Gctaacacac   Tcttccgctt   Ggatttctgg   Caggattcac   Taataaccat   7140     Ttccaccttg   Accagggtgc   Cttgtccttc   Tgtttccgca   Gcaatgatag   Gccacttgaa   7200     Tttggggtct   Tggtggatgg   Agactacctt   Ctcatccaaa   Gatgtggcca   Tcaaggagaa   7260     Gtctttccca   Tcgtaaatat   Ccaagggcgt   Gactgagcca   Tcactgaact   Ggacccagca   7320     Actgatggct   Gcttcctatg   Gagaaaaata   Tgtaagttaa   Tcaaatgggc   Caaaaagctc   7380     Attgagcccc   Aagtcttagt   Acagtagaca   Cacaacggca   Aaactattgc   Tacaagaaca   7440     Aagacaaacc   Tttcaaacag   Tgtagaaata   Agcgataaga   Agtaccaaga   Gtataaaaga   7500     Aaatgaattc   Tcacaaagat   Gcaaaaaagc   Aaaataaaac   Aacaacaaaa   Tgacaaaaca   7560     Gggccagtat   Taaacaatcc   Gtaagaagat   Ttgctttttt   Tttttttctc   Ctgtaggtgt   7620     Tgttataaaa   Ggaagatggg   Cccttgggct   Gttcagaatc   Aacttctgaa   Caataataaa   7680     Ttgcacgaca   Aaggaaatta   Ctggttagtg   Gaatcattta   Caagtgttac   Acattcaaat   7740     Gaaaaatatt   Tattacatta   Tttttaagtt   Gtaatactga   Gtctccactg   Attactggca   7800     Atacagataa   Aagcctctga   Tctagatgag   Gtcccactgc   Agggctgcag   Gctgtggttt   7860     Tgccagccct   Gccttttctg   Ggtctgcagg   Agtggatctg   Tcctggcctc   Aggccatagt   7920     Cttggcttgg   Agggaggagt   Taagcctgac   Agcaggagag   Ggagaagcat   Cttgattgga   7980     Gagtcttcat   Ctcttcctcc   8000       <210>   76   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   IRX1     <400>   76   Cttctccagg   Aataaaaaat   Ccctcccatt   Tagaaaactg   Actcataata   Ataatgataa   60     Caacagcagc   Accttgcaag   Taaactttcc   Atgaagcctt   Aacaccagct   Taatcaagtt   120     Agcttaaact   Gcagttgcac   Accaacgccc   Gtccccctcc   Actaccgcct   Ctgggccttt   180     Cctctcctcc   Ccgcccaacc   Cccaccccca   Cagcctgccc   Cctgcgctcc   Ccgagacacg   240     Cgcgctctct   Gcccatgccg   Ctgcagccgg   Aggcctgcat   Ctgtcccagc   Cctggacgcg   300     Ctgaaggtcc   Tagcttccca   Gcaggggtgt   Cccagtcacc   Ccccattgcc   Gagcttcgcg   360     Gggtcttgcc   Agccttctgg   Gccacgtgcc   Ttgggtcccc   Ggagcactgg   Ggcccaaggg   420     Cttccggact   Gtagccccgg   Cgctaagcag   Gaggagctcc   Gattccgctg   Cgcagcgacc   480     Ctagagctg   Gttttgtcag   Gctcctcgtc   Tttgtctctg   Gcacagtgac   Cagggggcag   540     Ccaccgggtg   Cggccagctc   Cgccaggagc   Aacttccgga   Gcagcggcag   Ggcctgcctc   600     Agccaccccc   Tttggaggca   Ggaaaagtgg   Ctgaggggcc   Aacaaagtgg   Ctctctcctg   660     Cctcagaggt   Ccaggccctc   Acagctgggg   Cgtcggtttc   Gaaggccaag   Cagagggaac   720     Cacacaacct   Cccattccaa   Tgtccatcgc   Ctttgcctgg   Cacccctagg   Gccaccagag   780     Ggatggtcct   Agatgccagt   Gatgctgagt   Ccgggcagcg   Gcaggggcag   Tctctttgag   840     Ggaaagtttt   Agacttctc   Acgacatttt   Taaaaggacg   Ttcaaatcag   Gcccacggat   900     Tccagacgca   Cagcccttct   Gcctgctcca   Gcatctgagg   Ccatgaagcc   Ctgggcccca   960     Ctgaaacatt   Tgctgctgaa   Aatgagtggc   Agaacgagtg   Ggaggaaact   Ctaccaggag   1020     Gggctgagcc   Aggatagtct   Agctccttct   Ccgcccctcc   Ccctctctga   Tgggatgctt   1080     Tggtggcaat   Tctctctctc   Tttctctcag   Tctaccctgc   Ttcctagtat   Ctagggtgaa   1140     Agttttgggg   Acaagggcca   Aggagaaaga   Agagaggagg   Tgagtcaggg   Cctgccaggc   1200     Tctgctagag   Cttcctagaa   Aggacttcct   Agaattggtt   Ttaggcgagg   Gacctggagt   1260     Gcagcctcag   Gccctggcct   Tgggcagaga   Atagaccaca   Atctcccctt   Ctgcaccttt   1320     Gcagggctct   Ccagggagca   Agttacccag   Ctttgctagt   Gccgcttccc   Caggaactgt   1380     Gcagtcctca   Ggcaggattc   Acaggggagt   Ctccaggtgg   Ggcccagcca   Ggtcctcccc   1440     Acccagctcc   Tccccaccca   Gctccctggt   Gttttgagga   Gcctgcaatc   Actttgtgat   1500     Gtgatgccaa   Tggaggtgat   Gcagccgggg   Cacagaggag   Tgggctggtt   Gagttaggat   1560     Gaagcctcca   Ctcccctatt   Cctgcctccc   Cacagagctc   Tgccagctgc   Agagagacct   1620     Gaggcttgcg   Ggtggggtgg   Gcggtggtgc   Tcagtgggtt   Ggatggaggc   Agataagctg   1680     Tagctgaatc   Ccaaggctga   Gaagtgtccc   Tggacttaca   Tcccacctca   Ttctccaggt   1740     Cactcaagag   Ggcgtatctc   Ccctgtcaac   Ctgaaatgtg   Acactgtagt   Ttgctgaaca   1800     Ggacaggggt   Gggtgggact   Ggcccacttc   Tcacacagtg   Agtcacaggc   Aatggatgga   1860     Tttgttttgg   Gtatagagga   Gaggaggttg   Aagatcggaa   Atctgtctta   Gggttagaag   1920     Gtgtctggtg   Gtaggctggg   Gaacaggaaa   Aagctgcagt   Taggggcttc   Cgggatttgt   1980     Gtcaccaaga   Atccactccc   Caccaaccct   Cggcgtcccc   Acaaacccag   Cccggaatct   2040     Atgtaaaagc   Aggaaaggaa   Ccctggaggt   Tgtaggcgga   Tcctggagtg   Tggaggggcg   2100     Aattgagcgc   Gggaagcagc   Atgactagca   Agacaatctg   Actcagagca   Gggaaaaatc   2160     Aagcccgatg   Tcggagctgg   Tttatagta   Ttactaccat   Cacgggcatt   Attgttgcta   2220     Atttaggcg   Atgtctcagt   Gtctgtcctc   Aggcccggaa   Aaccggagcc   Cctcctgatg   2280     Ctgctgaagt   Ccctgggcct   Cgaggctccg   Tgaagagagg   Gaagcgaggc   Agggggtgaa   2340     Gggaccgcct   Ggccggtgtc   Caggatacgg   Gtggctcaaa   Ccaccagcag   Aacagcatgc   2400     Cgactctggc   Ccgatggccg   Ccttcatccc   Gtagccccaa   Cccggcctaa   Agccgagaag   2460     Acgccagagt   Gcgctgctga   Aattcccgcg   Gagtccggtg   Tgctggagag   Ccgcagcggg   2520     Gtgaactccc   Ggccccgtct   Ctgcgtagga   Ggtggttcgc   Aaagtggccc   Cgggagccgg   2580     Gactggtacc   Cggttcccca   Cggcaccgtc   Cggagctctc   Cagccacgag   Gcgcagaagt   2640     Ggcctgccag   Cgccttccca   Ggctcaggga   Ggcgaggagg   Cccgtgcact   Tggcatcttc   2700     Tcccgggagc   Cgcacggcca   Gggccgcggc   Gaaacggagc   Ccatctcaag   Tgcgccgcgc   2760     Ctggccgcgt   Cctgtagccc   Gacgaggctg   Agtagggaga   Ggggagacgc   Agggagaaga   2820     Gggacgcggg   Acttggaccc   Aagaggccgc   Tccgttgccg   Gtctggcggc   Ggcgccgact   2880     Cgggttcgcg   Cgttccacac   Aagtttcctg   Tctgcctctg   Cacacctggt   Ggacaaaccg   2940     Ggcgtccagg   Ccacaccgtc   Ttcccccttc   Gcgggggcgc   Gggggatgtt   Tccctccggc   3000     Tgccaggggg   Ctttctgggt   Gaagagaaag   Cccctccccc   Cgcgtctccc   Ccaccccctcc   3060     Ctccgagaac   Ccgcggcgcc   Gactgcgcct   Gcttcccccg   Agctggcgac   Ttctccgcgg   3120     Gatttgccct   Cgctcaaagt   Ttgcacaatt   Gaaagagccc   Gcagagctcg   Gccgctcccc   3180     Gcttccccaa   Gggcggcgag   Gccggtcatt   Ggcagacgat   Cggttactac   Ccagtagggg   3240     Cccacgggaa   Cccgcatctg   Gagtcggggg   Tgtcacgcca   Cgccggttca   Gtggctcgcg   3300     Gagagcgtcc   Gggtgcactt   Ctgccaaaga   Tgtcccctgg   Aggccccggc   Cgcgcgggac   3360     Tcgggggaga   Ggccgctccc   Ccctcgctgt   Caccagcgtc   Caggccgccg   Gccccttccc   3420     Cgctgcccaa   Acagtagaaa   Agcaggcgcc   Aagttgtttt   Tgttaaaaag   Gggacacacc   3480     Tcggccgcga   Aactgcaaac   Ccggtgtcag   Acagctgtaa   Acccgtgtcg   Acaggttgtc   3540     Agacagctgc   Gggggctggt   Cgggaaggag   Cccacggcct   Ccgggcccac   Accccgccgc   3600     Cccgacgcgc   Gcgcccaccg   Cgagagtagc   Tggccgggcc   Ggcacggggc   Accacgtgct   3660     Cgcgggaggg   Gcgggagcgg   Ccggcgaggg   Cgggcgggag   Gcagggaggg   Ggcgggaggg   3720     Gagccagggg   Cggggcctgc   Gctcaagggg   Atgccaatca   Aagcatcaac   Ttcaaattgt   3780     Gtctgaaagc   Cccgccgccg   Agcggagggc   Ggccgccgca   Gtcggcgcgc   Gattgcggat   3840     Ccgggcgcag   Ccgggagccg   Ggcgcctgcg   Agcaccgggc   Agaggagccg   Cgaccggcct   3900     Ccatctcccg   Gcccgcccga   Gcgcgcccgg   Ccggccgccc   Gctcctccct   Agacccctcg   3960     Cggcgccccc   Tgcaaccccc   Tccggccggc   Ctccgcctcc   Ctccccgcgc   Ctttaatact   4020     Cgcccgctgc   Ggcggtcgcc   Gagtccgcgg   Acatgtcctt   Cccgcagctg   Ggctacccgc   4080     Agtacctgag   Cgccgcgggg   Ccgggcgcct   Acggcggcga   Gcgcccgggg   Gtgctggccg   4140     Cggccgctgc   Ggcggctgcc   Gccgcctcgt   Cgggccgacc   Gggggccgcg   Gagctgggcg   4200     Gcggggcagg   Cgcggctgca   Gtcacctcgg   Tgctgggcat   Gtaccggggg   Gcggggccgt   4260     Acgcgggcgc   Gcccaactac   Agcgccttcc   Tgccctacgc   Cgcggatctc   Agcctcttct   4320     Cgcagatggt   Gagtgcgccc   Ggcctccccc   Gcttctcctc   Tgtctcaccc   Gcgccagggc   4380     Aagggtggcg   Ggtcgcccgg   Gagggagaga   Ctacgggtgg   Acctggtccg   Gaagaggaac   4440     Tagaaaggtc   Cgggggcagg   Ttcccggtgg   Ccgaggccgc   Ggcccccggg   Gacgcaagag   4500     Ggctgggagg   Ccgggcgggt   Gagggctggg   Ccatctcggc   Ctgggaaagc   Ggaaggcccg   4560     Ggccagggag   Cgggtagcga   Gtgaattcag   Agaggccgca   Gaagcaggcc   Cgtggagcgg   4620     Tgcccgcgct   Ggaggtcggg   Ggcaaactcg   Cctggctcgg   Ccagggcgcc   Cgggcaggcc   4680     Cacggggttc   Ctgcaggtcg   Gcccggcgta   Gcgtagcagg   Acttcccttc   Ctggccgcgg   4740     Gttccactcg   Cgcggcctct   Ttagttttcg   Aaccgagtct   Ggaaaacttg   Gttttctccc   4800     Tctttagcag   Ctccgagata   Gttgtatccg   Agtttgccag   Acagacccct   Tctaagcctg   4860     Gtagagtcaa   Tcaaaataat   Cttaacaata   Gaggtccaaa   Gggatggaga   Ggtctctcca   4920     Cggcgtgagt   Gcgaatttga   Gattacaaca   Aaattaagtt   Gcagtaatgt   Gctggtgtct   4980     Gaaacggtgt   Ttgattttac   Ttttgtaagt   Tgcccaagtt   Ttcatttcat   Ttgcacagaa   5040     Agaaaagcac   Ttttcttcct   Gcgttacata   Atggaggatt   Aaagaaaaca   Gtgtcccttg   5100     Gcttaaaaca   Aatggtgtcc   Tcttagtctc   Ccgtcccagt   Gggcgttaga   Tgtcggggca   5160     Ggcggctgca   Cacttaattc   Tccgcggggg   Cattggcctg   Tctgccggtc   Caaatcatcc   5220     Attttccttg   Gtctgactgc   Aaggtcggtg   Cttaaacttc   Ggacggctgg   Tgaattgtgc   5280     Ggcgggcgcg   Gggccctggg   Aggcagcccc   Ctcctgggtc   Gctgcccgcg   Gtagataagca   5340     Atttccaagc   Acccgcgata   Tctccccgct   Ccccgcagga   Gaagcgggga   Gtaaacgccc   5400     Ctcaagtgtg   Cacaagcaaa   Gagggggttt   Ccctgtaact   Tttcttgtag   Ttttgaaaga   5460     Aagcggcccg   Gctgcctttc   Aggtctctta   Ctatcgaaaa   Agatcagccc   Ccattttgtt   5520     Caggcggcgg   Ggaggccggg   Acgcgatgag   Agatttacaa   Ggtgtccttt   Caaaaagaat   5580     Tcccagtgga   Gacgaggctg   Aaacgtcttc   Tttacaatta   Caaccaaaat   Aattagaaaa   5640     Gcgcaaagta   Cattttggaa   Cgattgggca   Aaaacgaaat   Ctagccgcag   Aaatgttttc   5700     Tctgcggcct   Cagtcaccaa   Actaattagt   Ccaagaaatc   Ttctggtctt   Tacaactttc   5760     Tcagagtccg   Gaactccctt   Tgctaacatt   Gcaactagac   Cattttttca   Gaggatgaat   5820     Attttttaca   Gaaattgcga   Atgcagttgt   Gtgccatttg   Ggaaccctgc   Ctgtgtttgc   5880     Gggggaggga   Gagagcttca   Gtgtgaggac   Ctgcaccctt   Tgtggagagc   Tggggaaggg   5940     Agatgtttgc   Tgttctgagt   Tgtttttccc   Acctagaggg   Ataatatgta   Aaaattattc   6000     Ccacccaaaa   Ggtgtgtgtt   Tctccagctc   Tcccactggt   Tctgagagag   Taaactcaaa   6060     Cccaaaccct   Gattctaggc   Ctaggtttcc   Aagccattat   Aattgggtgt   Ttggaagtca   6120     Aaagataaaa   Ttgtatttga   Atgtctgtct   Gcgcaattta   Tggtaataat   Gaggcctaat   6180     Gaggttgtta   Gaaagataaa   Atgttattta   Ccaaaaaacc   Tgatgggata   Atttgacttg   6240     Ctgtgtttta   Ctactgatta   Taaaaagaat   Atcgattgca   Aataaatcag   Cgcctctaaa   6300     Tgcctgcaaa   Cagctagtgt   Ttgctccctc   Cagatcaaag   Tcaaacttaa   Gagatgaagt   6360     Aactgagaag   Aggcctagga   Tactgaaccg   Gttcccctcc   Tggccgccgg   Tggctcccag   6420     Cccttgcgtt   Aatattttac   Aggctaagcc   Ttccttttgt   Attaaaaaa   Aaaatggtgt   6480     Ttttgttatt   Gttgtcgatg   Atggccggga   Ttaaaatttt   Aaattacctg   Tcacctctaa   6540     Agactttta   Atgtgggtaa   Accattatat   Gcagattaat   Ttggaaggca   Aaggactgtg   6600     Ctttcgtttt   Aaattgctgg   Cggatttaga   Ccggtagaaa   Acccgggatg   Gtttattttg   6660     Attgagcccc   Ctctgggtgg   Cagagaggag   Gcttgggctc   Tgggcccttt   Acgtttggag   6720     Aaatggcttt   Atcagctcag   Ttgaaaggtt   Tttccctcta   Gctagtgaaa   Gataaacttg   6780     Gaaatgcagg   Tttctccagc   Ggttggtggt   Ggggacaggg   Gtcgcctagg   Gaacttgcag   6840     Gggccgcggc   Ctctgttgtg   Ctcttctgga   Gagtgcactg   Tttgtggaac   Ttttctagag   6900     Tggcaaaaac   Gatctccact   Gtcggtgaaa   Gggcagttcc   Tgaagtcagc   Tcatggtcct   6960     Ggctcccctt   Ctccccagca   Gtgaactggg   Ggtgacttcc   Tgatctgccc   Agcacaggag   7020     Agccccgcaa   Agcgcctggg   Aggccctcga   Gtccattgaa   Gcggctgctt   Cccactctcc   7080     Cgtcttgggg   Actcatgtct   Ctctctctct   Ctccctttct   Ctctccactt   Ccctcctctc   7140     Tctcctcgat   Ggatctgccc   Tgtggcttca   Gggctcgcag   Tatgaactga   Aggacaaccc   7200     Tggggtgcac   Cccgccacct   Tcgcagccca   Cacggcgccg   Gcttattacc   Cctacggcca   7260     Gttccaatac   Ggggaccccg   Ggcggcccaa   Gaacgccacc   Cgcgagagca   Ccagcacgct   7320     Caaggcctgg   Ctcaacgagc   Accgcaagaa   Tccctacccc   Accaagggcg   Agaagatcat   7380     Gctggccatc   Atcaccaaga   Tgaccctcac   Gcaggtctcc   Acctggttcg   Ccaacgcgcg   7440     Ccggcgcctc   Aagaaggaga   Acaaggtgac   Atggggagcg   Cgcagcaagg   Accaggaaga   7500     Tggagcgctc   Ttcggcagcg   Acaccgaggg   Cgacccggag   Aaggccgagg   Acgacgagga   7560     Gatcgacctg   Gaaagcatcg   Acattgacaa   Gatcgacgag   Cacgatggcg   Accagagcaa   7620     Cgaggatgac   Gaggacaagg   Ccgaggctcc   Gcacgcgccc   Gcagcccctt   Ctgctcttgc   7680     Ccgggaccaa   Ggctcgccgc   Tggcagcagc   Cgacgttctc   Aagccccagg   Actcgccctt   7740     Gggcctggca   Aaggaggccc   Cagagccggg   Cagcacgcgc   Ctgctgagcc   Ccggcgctgc   7800     Agcgggcggc   Ctgcagggtg   Cgccgcacgg   Caagcccaag   Atctggtcgc   Tggcggagac   7860     Agccacgagc   Cccgacggtg   Cgcccaaggc   Ttcgccacca   Ccaccccgggg   Gccaccccgg   7920     Cgcgcacggg   Ccctccgccg   Gggcgccgct   Gcaacacccc   Gccttcctgc   Ctagccacgg   7980     Actgtacacc   Tgccacatcg   8000       <210>   77   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   MIR124-2     <400>   77   Actacaatta   Tttggatctt   Taaatggagt   Ggtggttttg   Tgagctcaaa   Aataatgaaa   60     Tgcaaactat   Ctgcttcctg   Tacattcaat   Ttggtggcaa   Atatagaaaa   Atgagaacaa   120     Ctgggatgag   Gaagagaacc   Taaagcctat   Agcatttccc   Cctttgcta   Tcattttaaa   180     Tgctagggag   Tctaatttgt   Gcagaagcat   Tgtgactttc   Atttttcaaa   Aggtaacact   240     Agcatgtcct   Ttcatgtgga   Tcaagaccat   Ggacagcgaa   Ctaatattaa   Atcactgagc   300     Aaaaaaggac   Tctaataaaa   Ttttgagacc   Tgagtgaaag   Tttacattca   Aagcatgtta   360     Gaagtcaaaa   Ataatcttta   Tggtctttaa   Aaggaattag   Actggtaaaa   Tgtggcattt   420     Caaacttatt   Ctaccaagtt   Tcaaagaaac   Aatgattatg   Tgttcagttt   Ttccctgcc   480     Tcaaatagta   Tatattactt   Atccaattaa   Aataagataa   Agcccacctt   Ttggtactgg   540     Taaatataaa   Atttaaaact   Atcagtttta   Gatgtagaac   Gttttttata   Aggccttgaa   600     Acagaatggg   Gatggagaaa   Ttttactatt   Ttagactggc   Attggctgaa   Tgacactaca   660     Gaaaattaaa   Ttgattttta   Tcagtgaatg   Aatttctaaa   Tgcataaaat   Tgggaaaatt   720     Aaatgccact   Ttgatagaca   Ggaataatat   Gaatggagat   Ataatccggc   Tattccttct   780     Actcccgtgt   Aggcattgta   Ctctataact   Gacagtgcaa   Tgttgtgagc   Aagcatttat   840     Tttttttcca   Gagaaltcac   Agattttttc   Atatatactg   Attagatttg   Ggacacagga   900     Ttggttcagt   Gtgggtctgt   Gctggagatc   Agcttatttt   Gttttataca   Ttgtttgaat   960     Agtctttact   Cctttacaga   Atataaatc   Atttaaaacc   Atttcatttg   Tggattacat   1020     Aacttattca   Aaattgctca   Tttaaatttc   Cagtttgatg   Tgtcttttag   Cttatttcat   1080     Aacctgactt   Tagtgtgacc   Tgtaaaggcc   Tggaaaatca   Tataaagcaa   Aaacaatatg   1140     Caggttagaa   Gaattaaaat   Agttcataat   Taaaattaag   Ttaaaattac   Atcatttaaa   1200     Aggaccttagg   Agtttataaa   Taaattaatt   Tttgatcttt   Attcatcaga   Tttggctata   1260     Aaatgaaact   Gcagttcttt   Gaatgtgcag   Gttgctggaa   Ttagatgcta   Catatatttt   1320     Gaacacacat   Acttatttta   Atattttagt   Tttagacaac   Gtattcaaag   Tacttgagaa   1380     Gaatatgcaa   Tgacattttt   Tccgtgtcct   Aatcaggacc   Atggtgaggt   Ccccgtggtt   1440     Caccgagtgg   Tggtccaggg   Ctctggttgg   Gacgctgagt   Taggttggca   Aagcgtcatt   1500     Gttttgaaag   Gcacattcgt   Ccggaatggc   Attcgtgata   Agattaaaca   Taaacctaaa   1560     Cctgtccctc   Gggggaaggc   Aggctgcggg   Gttgagaaga   Ggagatgcag   Attagctctg   1620     Cttttgctgc   Ttgcgcacat   Aattaagagg   Cggtccctca   Gctggagcgt   Gggctgtgtc   1680     Cggcctaagg   Tgcttatttt   Cctgttactt   Ggccaaccga   Gtgtgagtga   Acaggagccc   1740     Gagagcttaa   Atgtgggatc   Tagataaggt   Gtcgactggg   Ttgtgggcgt   Ttgtctccat   1800     Gttagggaga   Ggcaactgag   Aacggtgact   Ttggcttgtt   Ttgagagagc   Ctgggttttg   1860     Acagcaggac   Ggcgaaggga   Gcgcttggag   Aggctggaag   Ctcgacgtct   Tagggagctg   1920     Cctgcgggca   Ctgggttgac   Gccaagaggt   Tgtcggcaag   Ggcagggctc   Ttgccctctg   1980     Ctgtacctag   Gctctgcaac   Tgggggctgc   Gagccttctg   Cggctctttg   Gtttcaagga   2040     Cacagcgagc   Tgctcaggac   Tttgggagcc   Aacatctgtc   Tgactggtga   Cgtcagcagc   2100     Ccgtgtaatc   Ctcttgtgct   Gaaggcagat   Gccttatttg   Tttggctgga   Gcgagccatt   2160     Aatccctaat   Tctggatcag   Caagcgaggg   Ggaaagaccg   Gaccgctccg   Acccaccccc   2220     Tccctacccc   Cacctcccac   Cttaaagcac   Cttataccac   Ggaaggctct   Cagcctcttc   2280     Tttcctctgc   Gaacgcgctg   Agcagcgatt   Gaaaacgttt   Tggtcctctg   Caggtttgaa   2340     Cagggctagc   Aggtctctct   Ccggatttct   Agggctatgg   Gtatatgtaa   Ttctttctct   2400     Catcgatcgt   Ttcgattctc   Ttgccggtct   Tgcagtttgc   Agggtcctaa   Acgaagaggg   2460     Gtggagattc   Gagagtgcgg   Gtctggcgtg   Tggtccaagg   Gagggggtga   Ggctgggaaa   2520     Gggggtgcag   Aatgcgggaa   Cggctgggac   Tgcacagaag   Gaccatctgc   Ggactcgttt   2580     Tcactgctcc   Agctcccgaa   Atcgtttctc   Tggacgcggc   Agtatccgca   Gcgcatgcac   2640     Cctcctctgg   Acttccgcag   Cccagacctg   Cgcttacagt   Catcgcgcca   Ccccctcccc   2700     Ccgggctgcg   Ggccccgcgc   Tccgtgggct   Cagggtcccc   Tccgcgtccc   Cctgaagcct   2760     Ggggacggag   Gtcgcgaccg   Gccgactggg   Gtcctgtcct   Cttgtcacct   Tgtatccctc   2820     Gcatgctccc   Tcccgcctcg   Tgtccctctc   Cccaccctcc   Ccctcctctc   Tcccgcctcc   2880     Ctaacactgc   Gctttgattc   Tgtttttcag   Gggcgcattc   Tggggtctct   Gcgcaagacc   2940     Agctctcagc   Tctctctcct   Ttcctcggac   Tctggagcgg   Gagggggcct   Ttccctcggg   3000     Tcgaccacgc   Cgtaggggac   Gccgtgaaaa   Gagccgtcgc   Gcccgctgcc   Tcctgcccgc   3060     Tgcgcagagg   Gctccgcccg   Tagaggtcaa   Cttccctcac   Ccttttctct   Ctcctgcttg   3120     Ccctccctcc   Gcccggccca   Ggcgcttcca   Gccccagact   Gtggccactg   Gctgaggagt   3180     Gcgagtcggc   Tgcgctgccc   Tgagcctaat   Ccctcttccg   Ggcccagacc   Cgaggtccgc   3240     Gctcctgggc   Agtggggaag   Ctttagtgag   Caggcttttc   Tctccgcagc   Aaacttgtag   3300     Ccagaccaga   Tgggccgccc   Agctctctcg   Ggactaggca   Ggtgcggatg   Agttaatttt   3360     Tccgcattac   Aaagaaagat   Gacccagccc   Gcccttggac   Tctcttttcc   Caaaatctcc   3420     Caaccaaacc   Cgcggtaacg   Ttatcaaagg   Acacagagcc   Caggcatatc   Tgtgtgttta   3480     Tcttacaggc   Acacacgcat   Ggttttctct   Tttatatgct   Agatttcatc   Cctgacagca   3540     Gaaaatgatt   Ggcaatggtt   Atgacggaga   Acatgcaata   Gcgtggtcct   Taaaaacctg   3600     Ccattcctta   Caagtgcctt   Agaaaggatt   Cagggcgaac   Caactgggtt   Aattgcattc   3660     Agtaaaataa   Cacgattaca   Aaattagatc   Tgtaccagag   Gggtaattaa   Cttggatcca   3720     Cgccgtcatt   Tgaaaactag   Atttataggc   Ttatgtatgt   Ttttaggcgt   Gtgctgtaaa   3780     Tggcatggag   Atatatgcat   Atgtatacgc   Aggcacacgc   Accgtctaca   Cttccacgga   3840     Acagactaat   Taacagcggc   Tctggcagat   Gtgtcagaga   Tgagcagaga   Caggagctgg   3900     Gcttatgagt   Tatgactcta   Ggggtagaga   Ctcagagcgg   Agagaggggg   Atgggcaggg   3960     Agagaagagt   Ggtaatcgca   Gtgggtctta   Tactttccgg   Atcaagatta   Gaggctctgc   4020     Tctccgtgtt   Cacagcggac   Cttgatttaa   Tgtcatacaa   Ttaaggcacg   Cggtgaatgc   4080     Caagagcgga   Gcctacggct   Gcacttgaag   Gacaccaaag   Catctcaggg   Tcagaaaggg   4140     Gaaaaagcaa   Ttgcagggaa   Tttagggggt   Agtaaaagga   Acccatctct   Tgccgcataa   4200     Atgcccccca   Cccccaccca   Ggactgattc   Tggaagcaac   Ctagtgttcg   Aaagggaaag   4260     Gctcctactt   Ttccattaca   Gccgcggaaa   Tccgcaggca   Aatctccgag   Gagaatttta   4320     Gggaagcttc   Attgacagct   Gtctggagag   Cagtagttcc   Cgcctgtgca   Aatattccag   4380     Agagttatat   Catttagaaa   Gcactagttc   Tttcaagaac   Aggtagtgtg   Attgtctgca   4440     Gtcctgggcc   Aagctgggaa   Aacaaaacag   Cagagagagg   Tgtaacatta   Aatagcgtcc   4500     Tgaccacact   Gcgcaagaaa   Cagcaaatga   Aacgtccaaa   Ctttggaaag   Atctgaagaa   4560     Cacttgccgc   Ccgcatttcc   Cctgtacttc   Tccctttttc   Ttcccaatct   Cgaggcgttc   4620     Atgcctggct   Ttaagacgcc   Aagataactc   Tcttgttttg   Gcattgtcgc   Aatgtccaaa   4680     Tcggtcaaag   Gagtgggata   Aggtgaaagg   Accaggtcag   Aaactttaga   Aggactcggt   4740     Aaattaattt   Gtttggaagc   Cagtgaggtg   Gactatgttg   Aggtagcagt   Tccgcaccac   4800     Gactttggag   Ccaaagaaaa   Acccaggccg   Aaaaagcgag   Cctgtatgtc   Tttgttctgc   4860     Cttggcctgc   Aggggttggg   Aacaaaggag   Aggaggtaag   Agtaggcacc   Aaagtagccg   4920     Cgccctccct   Gcctggcgct   Gtccgcggtg   Ctgaccgtgg   Cccttttctc   Tctccgtaat   4980     Caaactggaa   Aagcaatagg   Accgtcccgt   Ccctactcaa   Aagaagagta   Gtagattagg   5040     Taatttgaaa   Aataacattt   Aaaaagagaa   Aaaggtcaca   Tacagcaaaa   Caatatttta   5100     Ctgaaatcgt   Tccctcaagc   Tggttgctac   Ccttgcctga   Cactttttgg   Tcttcacgta   5160     Ggaatgcaca   Catacataca   Ttgtaagtgt   Atggggaaac   Catttccact   Tttattaggc   5220     Tgaaacctaa   Atcgcaggat   Tgcaagaagg   Aaattgagga   Gaatgaaggc   Tttattatta   5280     Tccttttctt   Tcttaaatca   Tcttccttaa   Aacagaaaca   Taaggtcctc   Agccgcggat   5340     Tttagtgctt   Acttggtcac   Caaagggacg   Tgcaatggac   Tcaagtgtgg   Gcctcgaggc   5400     Ttaactagga   Aggggtgggt   Cggggaccca   Ccaggtgaaa   Cagggcagga   Gcccatgcag   5460     Cttgccacct   Tcggccaggc   Cttgcagccc   Ggcagcctta   Gtagacgggt   Acagagggct   5520     Gagctctgca   Gaccgctctg   Ctgcgcagga   Gcctgctcgg   Cgcatcccag   Ccggcgggag   5580     Gcactggagg   Gccaggaggc   Ctgaaacccg   Cactgcggaa   Aaaccgacct   Cagccacatc   5640     Ctcatagctc   Acgcgacgga   Aagaggcagg   Gcggtttact   Aaatcttatg   Cagtgaaaat   5700     Tcgccttaga   Aatcgaaggt   Tggatgagtc   Agtattgata   Tattcaaaaa   Tctaaatttc   5760     Ttagcatatt   Tcatcgttct   Tagatgttga   Aagtattaaa   Tgtaaacaat   Acaaatttaa   5820     Attccctaag   Taatgaatca   Aaatggcaag   Ggagagagag   Agagagagag   Acggaaaatc   5880     Aaccaattcg   Tagccaccct   Ggctggctat   Ttctcaaaag   Aaatttctat   Gcatttgctt   5940     Gagtttgtct   Ataaattcac   Aaacataaag   Ggtgttaaaa   Ttagtaacag   Acaaaataat   6000     Tcaggttgga   Caatagagac   Agcaacaccg   Attttgatcc   Aggtataaca   Atgggccatg   6060     Cattgacaat   Gacctaaaag   Acatgtgttc   Attatagtta   Tttttttaca   Cgggatgtag   6120     Atgtatcata   Aaattcatga   Aataaagcgg   Ccaggtgcaa   Tatcctcaga   Gagctgcctt   6180     Ctcaccccct   Gcctcagggc   Ggattttatc   Tgtcctcgaa   Ttttagaact   Ctgcaagtcg   6240     Ggtctttcac   Attcatcgat   Tactttggtt   Tatatttaat   Tttatccaat   Ttcggagtgg   6300     Gtgggtaaag   Cacactggaa   Aataggggct   Gctcgaatta   Caaaatttaa   Ggattgggaa   6360     Tattcctctt   Gtgccaatta   Aaagcagtcg   Ttggaagcag   Aaatgaattt   Aaagcattac   6420     Acgttatcat   Ggcggccttg   Ctttttcctt   Ccagtattca   Tccaattgcg   Ctgatctcct   6480     Gcatccacat   Cttgcgtaat   Ccacaaagca   Gctatggtcc   Agggctgcaa   Aatcgtcctg   6540     Cctgattcct   Ttagaattca   Tactacctca   Gaggagcaaa   Cctaatcccc   Tcagcctaat   6600     Cctacctgtt   Taggatcatc   Taaacttgtc   Cttcagaaag   Cttgatcagt   Ttaaaattgc   6660     Tttctaaata   Gaaatgaaat   Acgtgatatg   Agagaggtta   Aaatactgct   Taaaaaggga   6720     Aacactcaat   Ttagtaattc   Ggttgcctag   Atgaaatcga   Gtggctattg   Atccgtgatg   6780     Tttctagatt   Tttaagacta   Tgtacttcct   Atttctttgg   Aaaataatca   Tccagtttga   6840     Tgcccattac   Aaattttcct   Gctatgaaag   Aaattctatg   Cgcggcagtt   Ttgcaataaa   6900     Acaacccggg   Cttcgcaatg   Ggagaacttc   Ggtgcggcgt   Gccgtgagag   Tcctttgaca   6960     Atctcagctt   Tcatctaggt   Ctgaaattaa   Agcttctcgg   Aataatttag   Gaacagcttg   7020     Acccgttgag   Atactcaagg   Acaaccctcc   Agggaaatag   Tatgtttcct   Tcctgggaac   7080     Aagatgctag   Cgcggtgcac   Cgggaggtat   Ctggtgtcaa   Caatgccaga   Gcgccctctg   7140     Ctgcctcaaa   Gaggcaggac   Accagttaca   Aaagccagat   Ggcacagtgg   Caataagcgg   7200     Aggaaacatt   Aagctcttag   Aaacgtttaa   Tctgtgaaat   Ttaaaagctc   Tcatcatatt   7260     Ctacttttga   Aagggccacc   Tgattttgat   Tttgagcact   Cctgtgagt   Tatcttctat   7320     Tctggaggat   Aatgaaaagt   Ccgtgttttg   Aagttttcag   Attatttctg   Tagttatatt   7380     Tctccactct   Ttctcgaatt   Ttatatggaa   Atacgaaatt   Gcaaatctaa   Gtgaaaaacc   7440     Tttgtgtaaa   Acaggtgagt   Ggagaagacg   Tcctggtttc   Tccaaataac   Taagatctaa   7500     Taaagaaaca   Aatcttaatt   Aaaataaaga   Taccgagcac   Atgttgttgt   Gttagtttaa   7560     Aacgataata   Aaaagaaaga   Aattaagtct   Cgatgtaaat   Cattgttttg   Ttgttttgtt   7620     Tcagtgatta   Acccaaattt   Tgaccagact   Tgaagttttg   Aaataagaaa   Gtgaattatt   7680     Ttaaagaaga   Gagaaaattt   Gcttcttatt   Aatatgtaca   Atatttttgc   Ccttaaaacc   7740     Tttgcaatac   Atttatacac   Acacactcag   Cttgcaaagc   Cttctttaga   Aaataaccca   7800     Ctctgagtag   Aagtaatgag   Atatggtagc   Agcatgggca   Aagccataag   Aaacgttatt   7860     Tgcattaaaa   Atgagttttt   Cagtatggaa   Aatcaattac   Caaatgaaat   Agagattttt   7920     Tttaaaggtt   Caaacctttt   Caaattttta   Tgttataggg   Tttatattga   Ttaaaataaa   7980     Tgtacgtttg   Tagttattca   8000       <210>   78   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   TRH     <400>   78   Ggagtttaag   Cccagcctgg   Ccaatatagt   Gaaaccctgt   Ctttactaaa   Aatacaaaaa   60     Aaaattagct   Gcgcatggtg   Gtaaaattac   Acgcctgtaa   Ttctagctag   Ttgggaggct   120     Gaggcaggat   Aatcgcttga   Acccaggagg   Cggaggttgc   Aatgagccga   Gattgcgcca   180     Ctgcacacca   Gcctgggtgg   Cagagcgagg   Ctgtctctta   Aaaaaaaaaa   Aagtttaaat   240     Taaaaaaacc   Caccataaac   Aaaattcaaa   Agtaaactca   Gtgaaactgc   Tttaggcctg   300     Tctgcagctt   Agggttgtta   Aagactctta   Accatctgca   Ggacatctat   Ggataggaat   360     Agggagcaga   Gaggctttga   Gagggaaaaa   Gaattcacgg   Aggcaggaat   Taggaaatca   420     Gagcctaccct   Accctgagac   Tcaatacacc   Tcctacaagg   Agtgtcgtgt   Gtcagagtga   480     Gtgtgtgagt   Gtgtgtgtca   Gtgtgtgagt   Tcgtgagact   Gtgtgagtgt   Gtgtgtgtga   540     Gacagtgaat   Gtatgtatat   Gagtgtgtgt   Gagtatgtgt   Gagtgtatga   Ggtgtgtgt   600     Gtgtatgtgt   Gtattgtggg   Tggcactggg   Agttagaaat   Agtgtacata   Ctcaccatta   660     Aattatccca   Tttatcattt   Tcaaaagcat   Agctgtatta   Atctgataag   Caactacagt   720     Cttgagattc   Aagcccattt   Gccttatcag   Gagaaaaaat   Tgcacgctag   Aaaaatatat   780     Gcaacacact   Gactagattc   Taagctctgt   Gagagaggga   Acagggtcct   Gacttcttgc   840     Cctgctgggc   Ccctgcttta   Aagtgtaggt   Gtcattatta   Ttcagatatg   Gcgaggccaa   900     Cagatcttcg   Ttacttacag   Ttcccaagag   Gagtgggcac   Accaagatct   Gcagagccat   960     Gggggaagca   Ccggggtcag   Tcaggaggca   Cagggagtgg   Gtgaaaacag   Gagagaaatc   1020     Ctttcttctg   Gcttcctcag   Ggaggaacgg   Acgagacagt   Gtgagcaggt   Ttacgattgg   1080     Ctagtttgga   Taatttcaat   Gggctctggg   Tcatcggggc   Tgtcccctag   Ttgtctggta   1140     Cgtggccctg   Aggtgactag   Ggagggggat   Agtggccctg   Agtgtgagaa   Ctccatagag   1200     Aaggtggtgg   Ggagagaaag   Ctctggattg   Gttggtttgc   Acatgaaagg   Ggcgccccta   1260     Ggagagttgt   Ttactttctg   Ggaggtggct   Aaccctagaa   Gtctctccaa   Ggtcagcaag   1320     Acctcagatg   Tcaaagcatc   Agaaaaaaca   Catggtaaat   Acaatcccca   Aggtccagaa   1380     Caggtcctgg   Tacttaggaa   Gggctcagta   Aatatttgtt   Tagtgaggga   Gagaagaaag   1440     Gatggaaggg   Aggaagggag   Ggaggaggga   Aggaaggaag   Ggagggaggg   Agggagggag   1500     Ttggcttgct   Aaggacaccg   Cagaggcctc   Taccatcctc   Tctggttcca   Tgggctgcag   1560     Gggagctctc   Ctgactcctc   Ccgatccaac   Caggacctat   Cctccaaaca   Ggccactcaa   1620     Atccctgatg   Atagaaaggc   Acctaatggg   Ctcaccaggg   Agcagtgttc   Cagccatctt   1680     Acccttcagg   Aggcagtttt   Gccatgcatc   Catgctcacc   Aagcctttgg   Tgccttaggt   1740     Gggatttctg   Ttgttcttat   Tgttgggagt   Tttggtgctg   Tttgtttgtt   Tgtggacagt   1800     Aatcctgcag   Agagaaaatt   Caaacagggc   Taagagctga   Cagtgaaaag   Caagcctctc   1860     Cacaaccctc   Tctgtcctct   Ctttccctgg   Cttctaggtt   Tccttcttca   Tgggtcttgt   1920     Ctaagaacat   Aagaaggata   Tgtgtggtgg   Ctcaggtctg   Taatcccagc   Acttgggagg   1980     Ccaaggctgg   Aggattgctt   Gaggccagga   Gtccgagact   Agcctgggca   Atatagtgaa   2040     Accctgtttt   Tacaaaacaa   Aaacaaaaac   Aaaaatctag   Cctggtgtgg   Tactggtgcg   2100     Tgcctgtaat   Cccagtgctt   Taggaggctg   Aggcaagagg   Attgcttgag   Cccaggagtt   2160     Tgaggctgca   Gtgagctagt   Gattgtgctg   Ctgcactcca   Acctgggcaa   Cagtgcaaga   2220     Ccccatctcc   Aaacaataac   Aaaacaaaac   Aaaaagaaca   Taagagcctg   Gcagcccatc   2280     Ttcctcacac   Tccacaaatg   Gcagcatcat   Atacacatag   Ttctctactc   Tgcttctggg   2340     Agcttattcc   Acatgagtgc   Atatggaact   Gccttattct   Tttaaaggct   Gcatagtacc   2400     Ccacagtttt   Agatgggtct   Tagttgactt   Aagtgtcccc   Ctcctgatgg   Acagacatcc   2460     Aggctggttc   Caattctggc   Ttgtataaac   Catgctgcac   Tgaataccct   Gaggtataca   2520     Ttctcatgta   Tagaggtggg   Agtatctgta   Tttagaattc   Tgaaaaacag   Aattgtctca   2580     Tggaaggtac   Atatgtgtta   Aattttcaga   Ttgccaccca   Aaagattgga   Tcaatttata   2640     Ccctcgtcat   Tgtgtacaaa   Agacaacagg   Tctatctgat   Ttcatcttag   Ctagggtggc   2700     Atttcttcaa   Atcctggagt   Ctagttggga   Gaccaagcct   Gaggtttcat   Gtttgcagtg   2760     Tctccctcac   Tgcctctgaa   Ctttttgagg   Gctggggctg   Agcctcattc   Acttctaggc   2820     Cttcaggacc   Taccaaggag   Tctgacacca   Tagtgggtgc   Ttgttaaatg   Tttagagatg   2880     Ggccgggtgt   Ggcggctcat   Gcctgtaatc   Ccaggacttt   Gggaggccaa   Ggaggaggat   2940     Tgctagagtc   Taggagttcg   Agaccagcct   Gggcagcata   Agaagactcc   Atctctacaa   3000     Gaaataataa   Taaaaaatag   Ccataaaaat   Tatggtgcct   Ggctgtagtc   Ccagctactt   3060     Cggaggctga   Ggtgggagga   Tcccttgaac   Tggggaggtc   Aaggctacag   Tgaggtcaga   3120     Ttgcaccact   Gcactccagc   Ctgggtgaca   Gaatgagacc   Ctgttttaaa   Aaaaaagtt   3180     Caagatggag   Gcagtcccca   Gggctagatg   Tggcagtccc   Acatctggga   Ctttgggaac   3240     Tgactcgggg   Ggcaagctcc   Ttggcaccca   Tgtgtttctc   Ctccctgctt   Cccctcccct   3300     Cctttgctag   Agttgggtga   Actccaatag   Attcctgtgc   Aggggctgca   Gactcgaatg   3360     Tccctcctca   Gtgacagggg   Caacacattg   Gaagacatta   Gggagtggtg   Gagactgtgg   3420     Tggccgagag   Cagccaggct   Cagctccacc   Tggctgttga   Caggaggaaa   Tgggggccca   3480     Ttctttttca   Agagaagcca   Taaatccaaa   Attttctaag   Tttacttggt   Tttaaaatgt   3540     Tggttattca   Gatttttttc   Aaaacactgt   Ggaagtcaat   Caaaattgtc   Catgaactgg   3600     Ttgtagccta   Caggccgcca   Cttttggaat   Tctgaaagct   Ttcctctggc   Tcctattaca   3660     Cagaggagaa   Aactgaggcc   Cagagaaacg   Gaggcactag   Ccaggaatga   Cacagttaag   3720     Attagcaccc   Tggagcctgc   Ggggtggctc   Acgcctgtaa   Tcccagagac   Gcaggagtct   3780     Gaggcaggag   Gatgacttga   Gcccaggagt   Tcaaggctgc   Agtgagccgt   Gatcgcgcca   3840     Ccgcactcca   Gtctggggga   Caaagcgaga   Tcccatctct   Ttaaaaaaaa   Aaaaaaaaaa   3900     Agtagagctc   Cgctcccact   Tgccccccat   Tctctctctc   Tctctctttc   Tctctctctc   3960     Tctcttgctc   Tactctcgcc   Cgtctgcgtt   Ctacattggt   Tctgcggccg   Tgtccctttc   4020     Gtgtgtgtct   Gccctgtgtt   Tctccgtcgt   Ctccgtgtgg   Atctcggtct   Ttgtctcgcc   4080     Ctctagctct   Ctcgtgcgcc   Tgtgtttaat   Cgtgcgcttc   Tctcaatctc   Tctgtccctc   4140     Cctttgcccc   Ctacaccggt   Gttctcgtca   Acagatctcc   Agaggtggtg   Cagaaacgac   4200     Cccgcgccgg   Cgccccatcc   Tgcggccagt   Gcctccgcgc   Cccggctccg   Gtccccaccg   4260     Tccccgcccc   Agatttccgg   Aggaggaggg   Gggcggggtc   Ccgcggggcc   Ggctgccgtc   4320     Agcgcccctt   Cccggcggcc   Gcgacccctc   Cccgctgacc   Tcactcgagc   Cgccgcctgg   4380     Cgcagatata   Agcggcggcc   Catctgaaga   Gggctcggca   Ggcgcccggg   Gtcctcagcg   4440     Ctgcagactc   Ctgacctgcc   Gactgcggat   Cccgagtccc   Cggatcccgg   Acccatcctg   4500     Tggagcccac   Tcctggcagg   Taaccgcccc   Aacccctctc   Cttccgcaga   Cggtgtccgg   4560     Gagcactgga   Aagggagccc   Tctcggcccg   Ccctcacctt   Cggttctctg   Agagcttcct   4620     Ggagaacagg   Gccggtgcac   Aggcgggcgc   Tgtgctcgca   Cccccgggtc   Ctccccgagc   4680     Gcaggccggg   Gaccggacgg   Gaggcacggc   Gcgggcacat   Cggaggctct   Cgctgctggg   4740     Cactcaggtc   Gccagagtcc   Gcagcgcggg   Gtgggagctc   Cgcggcaccc   Cctgcctggg   4800     Tgccgccgga   Cagagctggg   Tattcagggc   Gtcggcctga   Gaacctggga   Gttcgaatcc   4860     Caatctcaac   Gctagaaata   Gaattttagc   Gttgaagtta   Ggattttagc   Gttagaatca   4920     Gattcctggc   Ttgtcatga   Aagcttagca   Ttagaaatag   Aatcttagct   Ttgcaaatag   4980     Actttgagct   Ttagaacctg   Aatcttagcg   Atagaaatgg   Gatcttcgcg   Ttggaatgag   5040     Gacgtcggcc   Acggagcttg   Gagttagaac   Gtggcgatgg   Ggacctttgg   Gggagtcttg   5100     Gcggggacgc   Aaccgttagc   Gtcgcggctg   Tgcctggcgc   Tgcaatctca   Atggttgcac   5160     Tcccggcgag   Gcagtcccag   Cgttggcttc   Cccagttccg   Cgtcacattg   Aagggtggcg   5220     Gtggcgctgg   Cgatggggtt   Cctacggcct   Cctgccttgc   Gcaagcagaa   Ctgggcgcag   5280     Gcactacagg   Cacccgtggg   Ggcgaggacg   Ctagaggtgt   Acaggtgtgg   Acgcagagcc   5340     Ggggcgaacc   Cgccgctgct   Cccgcccctg   Cacgaggggc   Agtggtcctg   Cttctgggag   5400     Ggcggttgaa   Ctgtgcgtgg   Tttgtttctg   Gcgggcgtcg   Ggggagatgg   Agcgggatgt   5460     Gctgtgattc   Ggtgcgctca   Ggctccctct   Gtcccctaac   Ccagacgccg   Cgatgcccgg   5520     Cccttggttg   Ctgctcgctc   Tggctttgac   Cctgaacctg   Accggtgtcc   Ccggcggccg   5580     Tgctcagcca   Gaggcggccc   Agcaggaggc   Agtgacggcc   Gcggagcatc   Cgggcctgga   5640     Tgacttcctg   Cgccaggtgg   Agcgcctcct   Cttcctccgg   Gaaaacatcc   Agcggctgca   5700     Aggggaccag   Ggtgagcact   Ccggtgagtg   Gatggggctg   Ttgggggctg   Tggggctagg   5760     Ctattgggag   Agccgtggaa   Acctgccggc   Aaaggggagg   Ggaggcttgg   Tcagctagcc   5820     Ttctgccttt   Cggaagctca   Gaaaccctcc   Ctggctgcgc   Ctaggcggga   Tctggagttg   5880     Accattcctc   Ggggtcagat   Tcctcccctg   Tctcaatgct   Gggaatattt   Cacagagagc   5940     Aggccctggg   Tggggaagct   Tctgtgtgct   Agggagagag   Tttctttgtg   Tgtgacagtt   6000     Tgaattacta   Ctgtctaggc   Acttctgtgc   Cagacactat   Tccaagcact   Tcaaacacct   6060     Tatcacactg   Tttgatcttc   Ctaacaacct   Cttagttagg   Tactgttatt   Acgattttac   6120     Acagaagaaa   Actgaggctc   Cgagagatca   Attgagtcgc   Tttaggtcag   Acaactaggg   6180     Agcgccagag   Ctgggattgg   Aacccagagg   Caatgccttt   Gactattgtg   Tgaatgtgtg   6240     Tatctgtgag   Gcctgagggg   Caggtgcaag   Accatgcctc   Tgagtgggag   Ctgcaggaaa   6300     Tgtaccctgc   Ctgggagaaa   Agcaggagtg   Ggcactcagg   Cgcctgccta   Ttacatgggt   6360     Caggggcccc   Tcactgacct   Ctttccttcc   Ccaggctccc   Agatctttca   Atctgactgg   6420     Ctctccaaac   Gtcagcatcc   Aggcaaaaga   Gaggaggagg   Aggaagaggg   Agttgaagaa   6480     Gaggaagagg   Aagaaggggg   Ggctgtggga   Ccccacaaac   Ggcagcaccc   Tggccgacga   6540     Gaagatgagg   Cttcatggtc   Agtcgatgta   Acccagcaca   Agcggcagca   Tcctggccgg   6600     Cgctccccct   Ggcttgcata   Tgctgtcccg   Aagcggcagc   Acccaggcag   Aaggctggca   6660     Gatcccaagg   Ctcaaaggag   Ctgggaagaa   Gaggaggagg   Aggaagagag   Agaggaagac   6720     Ctgatgcctg   Aaaaacgcca   Gcatccgggc   Aagagggccc   Tgggaggccc   Ctgtgggccc   6780     Cagggagcct   Atggtcaagc   Gggccttctg   Ctggggctcc   Tggatgacct   Gagtaggagc   6840     Cagggagctg   Aggaaaagcg   Gcagcaccct   Ggtcggcggg   Cagcctgggt   Cagagagccc   6900     Ctggaggagt   Gaacccagtt   Ttccctgaag   Tcgagtttgt   Ggtctaagga   Tgtcttgagc   6960     Cctgtgtgcc   Ccaccattca   Tgacctctgt   Attctctagt   Tagatccctg   Accataagcc   7020     Tgagcccctc   Cctcccagcc   Ccatattcac   Acacatccca   Gcccctggcc   Ttgccctctt   7080     Cctttaggca   Tgtgagaaaa   Tcagcctagc   Agtttaaacc   Ccactttcct   Ccacttagca   7140     Ccataggcaa   Gggggcagat   Cccagagccc   Ctctcacccc   Ccccaccaca   Ggcctgctcc   7200     Ttccttagcc   Ttggctaaga   Tggtccttct   Gtgtcttgca   Aagactcccc   Aagtgggaca   7260     Gggagcccct   Gggagggcag   Ccagtgaggg   Tggggtggga   Ctgaagcgtt   Gtgtgcaaat   7320     Ccagcttcca   Tcccctcccc   Aacctggcag   Gattctccat   Gtgtaaactt   Cacccccagg   7380     Acccaggatc   Ttctcctttc   Tgggcatccc   Tttgtgggtg   Ggcagagccc   Tgacccacag   7440     Ctgtgttact   Gcttggagaa   Gcatatgtag   Gggcataccc   Tgtggtgttg   Tgctgtgtct   7500     Ggctgtggga   Taaatgtgtg   Tgggaatatt   Gaaacatcgc   Ctaggaattg   Tggtttgtat   7560     Ataaccctct   Aagcccctat   Cccttgtcga   Tgacagtcat   Cctaatgata   Ataaaacctg   7620     Catccagata   Atcacggagc   Tctgtggttg   Ctgttctgtc   Gcagctggca   Tgggattctt   7680     Ctttcgcatt   Gagagggata   Tttaaaaggg   Gatgggacta   Gagttctcag   Ctctgctgca   7740     Gagggaatca   Gggaccctgg   Gaggatgaca   Agtcctctct   Actgtcccca   Tttcagaaca   7800     Cacttgggag   Gtggatgggg   Ttctggagcc   Catttgactc   Ctggggagac   Taaggcctgg   7860     Agagaaggaa   Gggcttgccc   Aaagacacac   Agctggctga   Ggtggagcca   Tgggtctgag   7920     Aggccagctc   Agggatttgc   Cttgagtttg   Cctgatttgg   Gaggcggggg   Tggtggtgag   7980     Aggggaggt   Tgaggggagg   8000       <210>   79   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PCDHB4     <400>   79   Tttccaaact   Taaacctata   Agatattttt   Aaagtcacac   Tcactgaaat   Gtacatgtag   60     Gaaggggata   Cttgaataat   Tagagtttga   Cttgagaaat   Ttgtgatgga   Atctaagata   120     Atttctaata   Attttttcta   Gaataaaaat   Agcatttata   Agtttaatat   Atcaaaatac   180     Tcaaatatgt   Gatatataac   Ttagaatata   Tctttacaat   Cagaaagtgt   Gggcttttca   240     Actttgttcc   Tcttttccca   Agattgtatt   Ctgggtacct   Cgcattttca   Tgtgaatttt   300     Acggtcactt   Taccaatttc   Tgcaaaaaag   Ccaactgaaa   Ttttgatagg   Gattgcacta   360     Aatctgtaga   Gcaatttgga   Gcataccaat   Attttaacaa   Tcttaagtct   Tccaatccat   420     Gaacactttt   Catttactta   Gatcttcttt   Aatttctttc   Aatgatgttt   Tgtagtgctc   480     Agtgttcagt   Tctcccactt   Cttttgttaa   Atttattcct   Aagcatttta   Ttccttttga   540     Tgatatctat   Tataaattcc   Attgctttct   Tgatttcatt   Tttgatttgt   Tcaatgctac   600     Tgtatagaaa   Tacaattgat   Ttctgtatag   Tgatcttgta   Ttctgcaagc   Ttgctgaact   660     Catttattta   Ttttagtagt   Ttttggtttt   Atttttttga   Gaaagagtct   Cactctgtca   720     Cccaggctgg   Agtgcagtgg   Cacagtcatg   Gctcactgaa   Gcctcaatct   Cccaggctca   780     Agcaatcctc   Ccacctcagc   Ctcccaagta   Gctgggacta   Caggtgcatg   Ccaccacctc   840     Tggataattt   Tttttttttt   Tttgtagaga   Caggatcttg   Ctagtgtgct   Caggctggtc   900     Tcaaactcct   Gacctcaagt   Gatcctcctg   Cttggcctcc   Aaaagtgctg   Ggattacagg   960     Catgagctgc   Catgcccagc   Ctcaaatttc   Tttaaaatga   Tttttatctt   Tcttcaacga   1020     Taaggttctt   Gcctatattt   Taccagagag   Caactagttt   Cctgcgtatc   Cctctatttt   1080     Atctttcttt   Gtattattaga   Aatgaaaaaa   Attaatatc   Atgcttcaga   Tctggcaacc   1140     Aattatgtaa   Atagtcatat   Gaatccttca   Gaatggataa   Cacagctttt   Ctgactggtg   1200     Tgaaatagtt   Ttcaggtgct   Cattctttac   Ttcattagct   Tatcttatat   Cattagctta   1260     Tcctccattc   Aggtataaca   Gatctttttt   Ttctgataaa   Tatggcagtt   Tagggaaata   1320     Aactatggca   Taatatgcta   Ggccattctt   Ctaggccacg   Cttcttgatt   Gtaaccttaa   1380     Accctttatc   Agaacctaaa   Caacttttca   Aaagatctat   Acatattttt   Atccaatgtt   1440     Taaggctatg   Agtaattcat   Tatgtcactc   Ttcatttttt   Tcacctgata   Atgatctcga   1500     Caaaaatgtt   Gagtattagt   Tttccttcca   Atgtgtaagt   Tgtataaaca   Tctctcttta   1560     Ctggtaacta   Actatctcta   Aagggagaca   Agtaattttt   Aagtttctaa   Taataattga   1620     Aaatttgaat   Ataaatatat   Ttcacctatg   Ataaccatgt   Acccaaggca   Aggctgaagt   1680     Tgggatctaa   Attatctgaa   Aagttgttca   Cctctccagc   Tctgcttagg   Tatagaaaag   1740     Aatggtttct   Ggagtcacat   Agtaacagtt   Taaatcctgg   Ctctgccgtt   Tcacatgctg   1800     Tatgactttg   Gacagattat   Ttaaactctg   Tgtgccacaa   Ttcttcgtct   Ttaaaatgtg   1860     Gctaataaga   Ctgcccacct   Catagggttg   Ttggggtgat   Aaaatgagtc   Aacatacgca   1920     Aaatgcttag   Aaaaatatct   Ggtgtatagt   Ggatatatat   Gttaatgtta   Ttgagatttc   1980     Atttactttt   Ggattgcaaa   Aggaactgaa   Aagacccaat   Tcttactcta   Tgtcaacatg   2040     Taggaataag   Taaacaaaat   Atggtttgaa   Ttttgtcctg   Aatgcattaa   Cttgaatcta   2100     Actaaaacct   Ggttactata   Ttagaaacaa   Ttttctcttt   Gatttgccca   Ggagatttgt   2160     Tttccagtta   Tgtctaaaat   Aatactcttt   Ctttttattc   Ttttcagtat   Atatttttat   2220     Tgtttttcat   Ttaatagtga   Tgcatagtgt   Atcttttctg   Atttacttta   Aatgtgaaag   2280     Aaaattctaa   Gatgttaata   Tttattattac   Tgccattgat   Atatccctta   Taggaattaa   2340     Tatatagagaa   Tagaatcaaa   Gtaaatttag   Tttataatag   Cttagcatgt   Attatattct   2400     Caaaattctg   Tattcagttt   Cagacatgtt   Caaggctgaa   Tatatgatct   Gacaataatc   2460     Tgcttatata   Gataaaaaca   Tcatttgagt   Ggattaattt   Attattacaa   Ctggtattta   2520     Ctaaataaaa   Tccatgtatc   Tttcacaatt   Tttactaata   Ctttctatca   Ctatcagaat   2580     Ctgaaatctc   Agatttcatg   Ctttaaaaag   Aattaattta   Acatgaatta   Taaattataa   2640     Ttacttatat   Gaattggata   Actaaataaa   Ataacaagat   Atttaagggg   Agaaaatctt   2700     Atatgtggca   Agatataggt   Tgctccattc   Agtgtattaa   Ttgcaaccaa   Taaattggtt   2760     Aactgtgtct   Cagtggtacc   Attctttctt   Attgtttgag   Agtaatcaca   Gtagctacac   2820     Actgtggtgg   Gatccatttt   Atacacaagt   Ctctttactt   Caccatatct   Gagtagagac   2880     Agcctaagtc   Accctttggt   Cacagaataa   Aatattttaa   Atcagtgctt   Cttgttttcc   2940     Ccaaaattag   Ctggtcaagg   Aatatgatat   Ctgggataca   Aaaggtgagt   Gtggtaacag   3000     Gcaaactcat   Tgtaaaatat   Agattacatc   Tatcttgcta   Aataagctca   Gcttaaagcc   3060     Tttatcttca   Caaaattctg   Tgactgttac   Tcacttttgt   Cttgacatta   Tcctcataat   3120     Agtcacatag   Aataatcaag   Tcctgttacc   Ctctgagctt   Cagttttagt   Ttccttatct   3180     Tttatttcct   Ctttagttct   Aagaatctgt   Gattctaata   Ctatttgcct   Tactcctagg   3240     Ttcaatgtag   Gttcacacta   Taaattactt   Gatacaaaac   Aagatacctg   Tctattcacc   3300     Tgtattacta   Tttgcacatt   Aaagtaggaa   Aatagaacct   Ttcgtttcaa   Aggtagtcgc   3360     Gctttagacc   Atgtatagag   Aacatcttaa   Acttttgcat   Catcacaaag   Tcctcacatt   3420     Cttagaaaag   Aacatttata   Actactaaga   Attgaattga   Aagtgtataa   Aaatttgtct   3480     Cctgtggctg   Gattatgtaa   Agaagaaatg   Gagttctttg   Aagtttcact   Gataagcgtg   3540     Tggggagtct   Gagatatctt   Cttgatttgt   Gctcatgatt   Attctggttc   Gtgcactgta   3600     Attaataac   Cttttaaatt   Atgcagttta   Atgtaacaaa   Gtttgtaaaa   Attctatgct   3660     Cttaaaaatg   Gcttttattt   Taaaacttcc   Caaatacgtt   Gtcttgaagt   Tgttaatttc   3720     Tcaatcaaga   Cgcagggtgg   Cgctgcaggc   Taagttgtga   Ataatgagcc   Ctaaaaagct   3780     Cgcgcgtatt   Cttctgtgtc   Gctagacgca   Atcaaaaaca   Cacggaagaa   Gcgttacaag   3840     Cagtgcaggt   Ttaccaacgg   Cttggggcag   Cgatatacta   Aacaaattta   Atattaaaag   3900     Caactgtgtg   Acgattcctc   Caagcaagaa   Attggaattg   Aatgtctcaa   Gtctcgttgc   3960     Ggttgctgag   Gggattggat   Atagggacct   Ggactccaac   Atgaagaagc   Tagggagaat   4020     Tcatccaaac   Aggcaagtgt   Tggcctttat   Tttgatggtg   Ttcttgtctc   Aggttcgcct   4080     Cgagcctatt   Cgttattctg   Tgttggagga   Aacagagagc   Ggctcctttg   Tagcccatct   4140     Ggccaaggat   Ctgggcctgg   Gaattgggga   Actggcctcc   Cggtcagccc   Gggtgctgtc   4200     Tgacgatgac   Aagcagcgtt   Tgcagctgga   Tcgtcagact   Ggagatttgc   Ttctgaggga   4260     Gaaactagac   Cgggaagagc   Tctgtggtcc   Tattgaaccg   Tgtgtactgc   Atttccaagt   4320     Gttcctggaa   Atgccggtgc   Aattttttca   Aggagaatta   Ttgatccagg   Acataaatga   4380     Tcactctcca   Atattccctg   Aaagggaagt   Gctcttgaaa   Atactagaaa   Atagccagcc   4440     Gggtactcta   Tttccgttgc   Taatagctga   Ggatttggat   Gtgggcagca   Atggtcttca   4500     Aaaatacaca   Atcagcccca   Attctcattt   Tcacattctc   Actcgaaatc   Atagtgaggg   4560     Caagaaatac   Ccagatttgg   Tgcaggacaa   Accactggat   Cgagaggagc   Agcctgagtt   4620     Cagcttaacc   Ctcgtggcgc   Tggatggtgg   Gtcaccacct   Aggtctggca   Cggtcatggt   4680     Tcgaatcctg   Atcatggaca   Tcaatgacaa   Tgctcctgag   Tttgtgcaca   Ctccatatgg   4740     Ggtgcaggtc   Ctggaaaaca   Gccccctaga   Ctctccaatt   Gttagggtct   Tagctagaga   4800     Tatagatgct   Ggaaacttcg   Ggagtgtttc   Tttaggctta   Ttccaagcat   Cagatgaaat   4860     Taaacaaact   Ttctcaataa   Atgaagtcac   Gggagaaata   Ctgttgaaaa   Aaaaattgga   4920     Tttcgaaaaa   Attaatctt   Accatgtaga   Aattgaggcc   Acagatggag   Gaggcctttc   4980     Tggaaaaggc   Actgtagtca   Tagaggtggt   Ggatgtgaat   Gacaatcccc   Cagaacttat   5040     Catatcttca   Ctcaccagct   Ccatcccaga   Aaatgctcct   Gagacggtag   Tctctatctt   5100     Ccgaattcga   Gatagagatt   Ccggagaaaa   Tggaaagatg   Atttgctcta   Ttccagataa   5160     Tctaccgttt   Attctaaaac   Caactttgaa   Gaatttttac   Accctggtaa   Cagagagacc   5220     Actggaccga   Gagaccagcg   Ctgagtacaa   Catcaccatc   Gccgtcactg   Acttggggac   5280     Acccaggctg   Aaaacccagc   Agacataac   Cgtgcaggtc   Tccgacgtca   Atgacaacgc   5340     Ccccgccttc   Acccaaacct   Cctacaccct   Gttcgtccgc   Gagaacaaca   Gccccgccct   5400     Gcacatcggc   Agtgtcagcg   Ccacagacag   Agactcgggc   Accaacgccc   Aggtcaccta   5460     Ctcgctgctg   Ccgccccagg   Acccgcacct   Gcccctcgcc   Tccctggtct   Ccatcaacgc   5520     Agacaacggc   Cacctgttcg   Ccctcaggtc   Gctggactac   Gaggccctgc   Aggcgttcga   5580     Gttccgcgtg   Ggcgcctcag   Accgcggttc   Tccggctttg   Agcagcgagg   Cgctggtgcg   5640     Cgtgctggtg   Ctggacacca   Acgacaactc   Gcccttcgtg   Ctgtacccg   Tgcagaatgg   5700     Ctccgcgccc   Tgcaccgagc   Tggtgccccg   Ggcggccgag   Ccgggctacc   Tggtgaccaa   5760     Ggtggtggcg   Gtggacggcg   Actcgggcca   Gaacgcctgg   Ctgtcgtacc   Agctgctcaa   5820     Ggccacggag   Cctgggctgt   Tcggcgtgtg   Ggcgcacaat   Ggcgaggtgc   Gcaccgccag   5880     Gctgctgagc   Gaggcgcacg   Cagccaagca   Caggctcgtg   Gtgcttgtca   Aggacatagg   5940     Cgagcctccg   Cgctcggcca   Ccgccacgct   Gcacgtgctc   Ctggtggatg   Gcttctccca   6000     Gccctacctg   Cctctccctg   Aggcggcccc   Ggcccaggcc   Caggccgact   Ctctcaccgt   6060     Ctacctggtg   Gtggcgttgg   Cctcggtgtc   Gtcgctcttc   Ctcttctcgg   Tgctcctgtt   6120     Cgtggcggtg   Cggctgtgca   Ggaggagcag   Ggcggcctcg   Gtgggtcgct   Gctcggtgcc   6180     Cgagggcccc   Tttccagggc   Atctggtgga   Cgtaagcggc   Accgggaccc   Tgtcccagag   6240     Ctaccagtac   Gaggtgtgtc   Tgacaggaga   Ctctgggact   Ggtgagttca   Agttcctgaa   6300     Gccaatattt   Cctaatctct   Tggttcagga   Caccgggagg   Gaagttaagg   Aaaaccccaa   6360     Gttcagaaat   Agcttggtat   Tcagttaagt   Attgtattta   Gttcagtgaa   Ccgcccgtta   6420     Gttttgtcaa   Acttcccact   Gcaatgcctt   Tatttaaaaa   Aattgtctac   Tttactaaat   6480     Attcatacca   Caatttcaaa   Cctactcatg   Tccctgataa   Agctaaattt   Gtcccttttt   6540     Tattgttatt   Aattgcactt   Aacattttta   Gttatactgg   Atattgagta   Tggattttct   6600     Ctatatttga   Tctattggtg   Atatacttt   Ttgtaatcat   Aaattactca   Attaggataa   6660     Aaataaatta   Tgttttaatg   Aaattcttaa   Attacatct   Ttttaatgga   Acatttaagt   6720     Gaatatatga   Atattgaatt   Tctaaatatt   Tgttgtgcct   Gtctttacca   Tgtaacttaa   6780     Tgtttgcaag   Gccagagtgt   Ttgaaagttt   Tgtatttaac   Tttataatta   Ccttgtcctt   6840     Tctggttgac   Tatactaggc   Taagccctct   Taatagccat   Gagtgtaaaa   Tttagtttac   6900     Tcatttttca   Caaattgtat   Ataaacatgc   Acttcactac   Attggtaata   Cactaaaatt   6960     Gtggtccttt   Tcctcttgtg   Accaccacat   Gtctagtgat   Tattttgttt   Atttggttgc   7020     Tacttaccta   Gcacattgta   Atgttccatg   Aatgctaata   Ttaaattttg   Taaaaataac   7080     Tttattataa   Ataattttta   Aagagaaaaa   Tctcatataa   Tttgtcataa   Cctttcaata   7140     Aataaaactg   Ttaaatcatg   Gcctgatatc   Atcttaaaaa   Aaaatctcag   Aatctgaaat   7200     Aagccctaaa   Tttctcccca   Aaatcaagac   Tcttgagagc   Atcataggtc   Tccttgtgct   7260     Accttttact   Ccctataaat   Agaaatccaa   Gtatacttta   Atatgtgtat   Attttttggt   7320     Tttcctacag   Cttctcccca   Tctttcaaaa   Gaatcacgaa   Atttcttctg   Caccttggct   7380     Attctgttta   Aatctgataa   Tcagttgatc   Tcaggttttt   Cactgtacat   Tactttgcag   7440     Atatggacag   Cctttacaaa   Aataattttt   Aaatgcttaa   Tttatttaat   Ttgttcttta   7500     Aggtaacctt   Cagttatttt   Gaattaattt   Aacttctcaa   Tttagccaaa   Gttgcacttg   7560     Catgaaataa   Atattatttt   Gtccttgtat   Agactggaac   Agtaataaat   Tttactgaat   7620     Taaaattgtt   Tttagctgtg   Atcagtaagc   Ccagtaagct   Aggtaaagtt   Gtatggatat   7680     Aactatagta   Cacctctatt   Ttacttttgg   Cagaatatga   Gcaactgaag   Aacttgcttt   7740     Ataatctaac   Atttattttt   Aaatctcaag   Tatcatccta   Ctggagttaa   Attacttgca   7800     Cttttccttg   Aattactctt   Gttttctaaa   Cgtgtaatga   Aataaaaagg   Aaaattgact   7860     Gttattcttg   Aaacatattt   Tttagcattt   Attcaattta   Aaaatcaaag   Tgaagaagat   7920     Ataaagtgag   Aacagaatat   Aacatacaaa   Tatgtaagac   Ataaatatgg   Tagtcaactt   7980     Taatgtcttc   Ttccatttat   8000       <210>   80   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ZNF132     <400>   80   Tttttgtacc   Aatgatagtt   Cccacatagc   Cctggcaggt   Ctgaaccagt   Tatgcctgcc   60     Tactgagttt   Tatatttcat   Gagtcatgag   Ccatgggcag   Gtactggggg   Atgtagctgg   120     Taaagtggga   Catgcattgg   Gaacagagga   Ccaaactttt   Gctgtggagg   Ttctcaaaga   180     Aactacccca   Ttcttcagag   Ctagctctgg   Gcccacaggt   Gaccctgtggt   Gtccagatca   240     Caagattcag   Tccaagcctg   Tcagtctttc   Ataggaggcc   Ttagggcaac   Aagacaaatt   300     Caaccaaaac   Tggactgagc   Actcttcctg   Cccatgcggc   Tgtttgagac   Actcagtgcc   360     Cccttacaaa   Agctgttctt   Tttatattag   Gatgaattgt   Ttcaaaccac   Ctcaccaact   420     Ctgatgcagg   Tggctaaaca   Ttaaggcctt   Tgttatctca   Gagagagaca   Ggcagatcca   480     Ggagtgagtg   Attgagacta   Aacagatcat   Tcctaagtgt   Cacatgtaga   Tgcaaacaat   540     Gtccatgaag   Agaaaccttt   Tcttctattt   Tagatggagt   Ctcacactgt   Cgcccaggct   600     Ggagtgcagt   Ggcacgatct   Cggctcactg   Cacaccctgc   Ctcccaggtt   Cacaccattc   660     Tcctgcctca   Gcctcctaag   Tagctgggac   Tacaggcacc   Cgccaccaca   Cctggctaat   720     Tttttgtatt   Tttagtagag   Gtgggttttc   Accatgttag   Ccaggatggt   Ctcgatctcc   780     Tgacctcatg   Atctgcctgc   Ctcagcttcc   Caaagtgctg   Ggattatagg   Catgagccac   840     Tgtgcccggc   Caagaaacct   Tttctggaaa   Gctccagaag   Acaccagctc   Agatcttagc   900     Aagaattgtc   Ataccaaaat   Ctaaagccat   Cagtgggaaa   Gaaaatgaag   Gtactcaaag   960     Cctatgtaat   Tctctctaga   Gaatggaaaa   Gggagtatag   Tctgctttcc   Cttagcacag   1020     Tgagggagac   Tgatacatat   Catgagatct   Tgccaggtgg   Cagagatgag   Acagtatggc   1080     Aggcagcttt   Ggacatggct   Tccaatgatc   Tctgccctct   Ggtattcatg   Ctcttgtgta   1140     Atgctctccc   Cttgactgtg   Ggctggacca   Agtgacttgc   Ttctaactaa   Atttagcaaa   1200     Gatgatggga   Tctcacttct   Gttattaggt   Tacaaatgac   Tgacttgttg   Gttatctcca   1260     Ctgcatgatc   Agcttgcaag   Ctttgattga   Caagctgcca   Ttttggagag   Gcccatgtgg   1320     Cagagaactg   Gaggaggtct   Cagaccaaca   Gacgggtcct   Cagtccagca   Gcccacaaaa   1380     Aactgaatgc   Tgccaattac   Atgagtttgc   Ttggaagcag   Agccttccct   Agtcaagcct   1440     Tcagatgata   Cacccccagc   Tgacatcttg   Atgttagcct   Tgtgagaaac   Cctaaagagg   1500     Agtcagctag   Ctgcaccaaa   Gttcctgacc   Tatagagact   Gtgaaatagt   Gactattgtt   1560     Ttaagccact   Aggttttgag   Taatttgtta   Cacagcaata   Ggtaactaat   Acagatggct   1620     Tctgcaatag   Cagtaataca   Gtgccgccta   Agattctggg   Agctgtggct   Ttcccacatt   1680     Tgttgcccat   Aactctcttg   Tgaattctct   Ggtgattttt   Cttaaaaggg   Ggtgtctata   1740     Gctgaaggct   Ttcccatttt   Cactgcattt   Gtaatgcctt   Tttcccatag   Gtactttata   1800     Tagctttctc   Acataggaga   Ggtgactgaa   Gaccatccca   Cattccttag   Atgcaggggt   1860     Tttctctact   Gtgaattttt   Tggttataga   Taagaatcga   Tttcttcttg   Agggtctttc   1920     Ttcataccaa   Gttatttaaag   Atctctcttc   Agtgtgggtt   Cttaggtggt   Tgaagagggc   1980     Aaaagtcttc   Atgtcttccc   Atagccactg   Ctcttgaagg   Gcttctccct   Atcatggcct   2040     Gcccggtgtt   Atctgatgtt   Agagctgtgt   Ggcagcatct   Tctcactcag   Ctcttcttca   2100     Tggcttccct   Gtgccatgag   Tactctggtg   Atggagaaag   Gaaggccttt   Ccacattctc   2160     Ttttgagctt   Ctcattattc   Tggtactcca   Gtgctggaag   Ggggtagtta   Ccctggaaag   2220     Ccttcacaaa   Tgcctggccc   Ttgagtcctc   Tcacttatga   Attttgctgt   Gcatgaactg   2280     Aaaagtgctc   Ttactgtgag   Ccatgtcaca   Tctgaaaagg   Tggtcttcac   Cataataggt   2340     Ctactgttgg   Tgaaggtttg   Atccactccc   Ttgtgtgggg   Tttctacctg   Gagtacactg   2400     Cctaacgttc   Agccaggagt   Acaatctttg   Gcagggcaag   Ggtgccatgg   Tcagggtgag   2460     Gaacgaccag   Tcatggagta   Ctggtcctgt   Cacatatccc   Actactgagc   Ctgttaggtg   2520     Acattcacat   Aggcagggag   Aacagagagg   Gatctaggac   Agatgtggaa   Gcagcagtgg   2580     Ctactgaaac   Tgctgttcag   Tgatgtgagc   Ccaggccacc   Cttcttttct   Agagatgggg   2640     Ccttgctatg   Ttgccctgga   Tggactcaac   Ctcctgggct   Caagagatcc   Tcctgcctca   2700     Gcctctcaag   Cagctaggac   Tagaggtgtg   Caccactgca   Cctggccagg   Cctctccttt   2760     Atggggactc   Ctgttcacat   Cccagccaat   Gctctcatga   Gtacttcctt   Gtataggggga   2820     Ggtcaaagaa   Acagcagcag   Ctcacatgtg   Atgatgctga   Aattacatgg   Taaataagct   2880     Ttttaaaata   Ggtgccggcc   Aggtgcggtg   Gctcatgcat   Gtaatcccag   Cactttggga   2940     Gtccaaggca   Ggcagatcag   Gaggtcagga   Gatcgagacc   Atcctggcta   Acatggtgaa   3000     Aacccgtctc   Tactaaaaat   Acaaaaaaat   Tagctgggtg   Tggtggcggg   Caactgtagt   3060     Tccagctact   Cgggaggctg   Aggcaggaga   Atggcgtgag   Ccatttagga   Ggtggagctt   3120     Gccgtgagcc   Aaaatcgcgc   Cactgcactc   Cagcttgggc   Gacagagcaa   Gactccatat   3180     Caaaaaaaaa   Aggtgccaaa   Caccatattc   Tacaaggttc   Tggatctcta   Gctccttcta   3240     Aaataccagc   Tctgtcaact   Gtgttaaatg   Cccccatctg   Cctgtgccca   Ctctgttggc   3300     Cagcaagact   Gtgaaggcat   Gaagtgtgtg   Ttagtgacca   Gaaaccctgg   Ccagactgca   3360     Aaaaccactt   Tcctggacgt   Caggctatca   Cttctctcag   Ctcccagttc   Ctacctgggg   3420     Agtgatgggt   Gccaagatac   Agtttgagag   Aggtgaagtg   Aatgtacatg   Acattgcatt   3480     Tatctgcttt   Aactgtggca   Aaaactttaa   Catggcaaat   Acaaaggtct   Gtagctctgg   3540     Agttgttctg   Cacaccctca   Ccctgcacag   Tcccagttga   Tggggaacta   Tggctattcc   3600     Tttgtccatg   Atggcatgtg   Ccctagttca   Ccagtctacc   Caaatccctg   Gttattacct   3660     Cacatccagt   Gtttctctat   Gcacatagag   Tcctccatgg   Acccctctag   Gtctttgcct   3720     Tggtgaccct   Gtgactattt   Tagtgttgta   Gatgagttta   Tttttcctct   Gggtaagctc   3780     Tgggccctac   Ggtaactgaa   Acaggccact   Atgttcaatc   Cagagccttt   Cagtctttcc   3840     Cagtctttca   Cacagcaatg   Caaagtaggc   Tacaacagga   Cagagcaact   Acccgctctt   3900     Ctactgtgcc   Cttaggcaga   Ttttgtgccc   Ccaaaaggca   Ctccccaatc   Tatccattca   3960     Ttttctcaac   Ctaccccaac   Agaaccccta   Agattaaagg   Tgacctgatc   Aataaggtct   4020     Tttattacca   Cagttagtgc   Aggcaaggta   Ggtgattcca   Gtggagggtg   Atttgtggcc   4080     Tcaatggaca   Catcttaggg   Gttaaacaca   Gacttgacca   Catccacaag   Gaatgtgcat   4140     Cttcctgagc   Tcaaattaga   Tttccctcaa   Ggcccctcaa   Ccagcatcgg   Ttcagctgag   4200     Cacagtcctg   Aatccctaga   Gaacacagga   Aggaaggctc   Agggtactgt   Tttccccatg   4260     Catgaggaca   Ggactgctgc   Aaatttttgg   Atccaggcaa   Gatggaaagt   Gactatggct   4320     Tctgccttat   Gctgcatggg   Tgagatggcc   Ctgcaaaggt   Tcctgggctg   Gtcagaaaca   4380     Gagtagcttc   Tgaaggcttt   Tccacattag   Cagtacatgt   Aggtaatttt   Tctggtatgg   4440     Ggattctgct   Gcatgaagtt   Tgacttggct   Gaagattttc   Tcacaaagac   Cacttccata   4500     Aggctccact   Caggtatgaa   Tctttttatg   Ctgtgcaagg   Ttacaaagat   Ggctgaagag   4560     Tttcccacac   Tggctacact   Cataagctct   Ttctctggtg   Tgaactttct   Ggtgccgaac   4620     Aagtgtagat   Ctttcactaa   Aggcttttcc   Acactggatg   Cactcatagg   Gcctttcttg   4680     Tgtgtgaact   Ctctgatgac   Gaaccaggtg   Ggagttactg   Ctaaaggctc   Tcccacattc   4740     Actgcattcg   Taaggccttt   Ctccagtgtg   Aactctccag   Tgacaaataa   Ggctggattt   4800     Tcggctaaag   Aatttcccac   Attcactgca   Tttataaggc   Ttttctccag   Tatgaacttt   4860     Ctgatgctta   Atgagaatgg   Agttttggct   Aaagaatttc   Ccacattcat   Tgcactcata   4920     Aggcctttct   Tttgtgtgaa   Ctctccagtg   Ttcaatgaga   Gtggagctgt   Gagcaaaggc   4980     Tttcccacac   Tcactacact   Cgtaaggctt   Ttctccagtg   Tgaattctcc   Agtgctgaat   5040     Caggctggag   Ctgcggctga   Aggatttcct   Acattcgctg   Cactcataag   Gcctttgccc   5100     Agtatgtact   Ttctggtgct   Ggatgagggt   Ggagctatta   Ctgaaggctt   Taccacaatc   5160     Acagcattca   Aaaggccgtt   Ctccagtgtg   Aactttctga   Tgtcgaagga   Gatgggagct   5220     Ttggctgaag   Tctcttccac   Attcactgca   Ctcaaaaggc   Cgttctccgg   Tgtgaacttt   5280     Ctggtgctga   Gcaaggttgg   Agttattgtt   Aaaagctctt   Ccacattcac   Tgcattcata   5340     Cggtctttct   Ccagtgtgaa   Ctctccagtg   Ctgaatgaga   Gcagagcttc   Ggctgaagga   5400     Tttaccacat   Tgactgcact   Cataaggtct   Tacctgtgtg   Tgaactttct   Gatgccgaag   5460     Gaaattggag   Ctttggctga   Aggctcttcc   Acatttcagg   Cactcaaaag   Gcctttctcc   5520     Agtgtgaact   Ttctcatgcc   Gaatgaggtg   Tgatctgtta   Ctgaaggctt   Tcccacattc   5580     Atcacactca   Taaggtcttt   Ctcctgagtg   Aattctctga   Tgatgaacaa   Atgtgagttt   5640     Gtggttgaag   Gttttcccac   Atgcaatgca   Ctcataatat   Tttacttcag   Tgtgaaattt   5700     Ctggtgcttc   Ctcagcttag   Atgagtgact   Aaaggccttc   Ccacactcct   Tacacacatg   5760     Gggtatttcc   Ccagtgtgaa   Actttttatt   Accaaggatt   Gatttctcct   Ctaagaaatt   5820     Tccacctgtt   Gggcatgtaa   Atggtatctc   Ttcagagtga   Gttctcagat   Ggttggggag   5880     Aggtgadcct   Ttcaggaagg   Cttttccaca   Gttgctgcac   Tcgaagagtt   Tctgtgtggt   5940     Acagacttct   Ggaagctgcc   Caagattgga   Atatggcttc   Tgcccactgt   Caacagcttg   6000     Aagctggagg   Aggtcacagc   Tgcccaggat   Gaccttccca   Ccttccctgc   Aagtgaaggg   6060     Gttctctgac   Aggtggactt   Tagagctctt   Cataaggcg   Tccctgtcct   Tgtaccatct   6120     Aaagggcttc   Cctccactgt   Gctccttctg   Gtgctggtga   Aggtttgcat   Tcaaccaaaa   6180     Gtctctccca   Catgctccac   Atgtgtaggg   Tttctcctca   Gactgtgttc   Cctgatgctc   6240     Agccaggtgc   Aaaatgtctt   Tcaagaatgg   Cccacacatg   Tcacaggagt   Tagctttctt   6300     Ggtggaagga   Tctgcattag   Ggatcctgac   Ctgtaacact   Tctacagaaa   Cattctgctt   6360     Gggatgggcc   Ccctcaccct   Ctactccatg   Ccaagaacct   Gaaagtagag   Aaatgccagt   6420     Taactaagaa   Ttccacttgg   Tgggaatggt   Tgacttcatt   Agaaatgtta   Cccaggaatt   6480     Cacacccaag   Aagaggtccc   Agggattgct   Gacaggccaa   Cagggccatc   Atcagggtga   6540     Gaagaggccc   Attactattg   Gcaggatagg   Gaccagccaa   Gcaacagaat   Aagggagacc   6600     Tcaccagggg   Taaggacaca   Gaaatgggtc   Aaaggactta   Aatagacatt   Tctctaaaag   6660     Aagatatata   Cacaaatggc   Caataagcat   Atgaaaagaa   Gttcagcatc   Cttaaacatg   6720     Aggagtatga   Aaaccaaaac   Cataatgaga   Taccacttca   Catccactag   Catagctata   6780     Ataaaaaaaa   Ataaatgaca   Acaaatgaag   Tagaaaaact   Ggagcactta   Tacactgcag   6840     Acagggtagt   Aaaatggtgc   Agccaatttg   Gaaaacagtt   Tggcaagtct   Gcttctacag   6900     Agctacacaa   Gagaactaaa   Aacatccaca   Caaaaatgtg   Tacaggactg   Ttcatagcag   6960     Aattttttta   Aaatttgaga   Tggggtcttg   Ctatgttgcc   Caggttggtc   Tcaaactcct   7020     Gggctcaagt   Gatcctcctg   Cctcagcctc   Ctgagtagac   Ggattatagg   Caccttgccc   7080     Agcttctata   Gcagcatttt   Tttctaacac   Ctaaaaaatg   Gaaacaagcc   Aaatgctcat   7140     Ccactggtaa   Atggataaac   Aaactgtagt   Ctttctatac   Actggaatat   Ttggctataa   7200     Aaaagaatga   Aatattgata   Cagctacaa   Cattgatgaa   Cttcaaaaac   Atgctaagag   7260     Aaagccagtc   Acagaaaaat   Acatagtatt   Ctataaaatg   Tctaggaaac   Gtaaatctat   7320     Atagtcagaa   Agtagattag   Tggttgccta   Ggaccggggg   Gaaagggata   Agggaacatg   7380     Gggagtgaca   Gctaatggga   Ctgctaatag   Gacctacagt   Ttctctttag   Gtgatgaaaa   7440     Catgctaaaa   Ttacattata   Gcaatgatta   Taccatgtga   Aaacatatag   Aaatcactag   7500     Actgtgtact   Ttaaaaggtg   Aattgtatgg   Tttatcttaa   Taaagctgtt   Tttaaaaaat   7560     Atctcactgg   Gggctgggcg   Tggtggctca   Cgcctgtaat   Cccagcactt   Tgggaggctg   7620     Aggtgggtgg   Atcacgaggt   Caggagattg   Agaccatcct   Ggctaacatg   Gtgaaacccc   7680     Ctctctactg   Aaaatacaaa   Aaaaattagc   Tgggtgtggt   Ggcaggcacc   Tgtagtccca   7740     Gctacttggg   Aggctgaggc   Aggagaatgg   Cgtgaacctg   Ggaggcagag   Cttgcagtaa   7800     Gctgagatca   Cgccactgca   Ctccagcctg   Ggggacagag   Caagactcca   Tctcaaaaaa   7860     Aaaaaaaaaa   Aaaaaaaaag   Gaaaaaaaaa   Tctcattggg   Aaagagacag   Aatctgggca   7920     Tgacctcata   Ctgggtaacc   Cgaccaggga   Ttggtgaatc   Tcagtgggat   Ctgttaggca   7980     Gactggaggt   Gtctgatccc   8000       <210>   81   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   KLHL33     <400>   81   Atcactgaaa   Aaaatcagac   Tagaacccag   Gcgaaccatc   Aaggttggag   Acagaggaga   60     Ggtgagcttc   Ctgacaggga   Gcataaaaca   Aaggaaagga   Agaacgtgag   Caacccagcc   120     Aggactaggc   Acaggagaca   Agtgatacct   Agagccccac   Acacttactt   Gtactaaaca   180     Ttaacctgca   Tgtccagtcc   Tacccagtac   Ctgagtcaac   Cttggaaaga   Taagagagat   240     Atcagaaatt   Tcaccctcac   Cagcaaaggg   Ggtggaggga   Agactgttgg   Gggagctatt   300     Agagagcatc   Tagaacacct   Tggcttatca   Tctgattcac   Caaaggtaag   Aatcccaggc   360     Ctctacagtc   Atcaaactag   Tcttgccagg   Tcaccaccac   Ggctgcccaa   Tctgtatgca   420     Tagtttctat   Cccaattcct   Acttctcact   Ccacttccct   Tctggggttg   Aaatgttacc   480     Ctgatattac   Cctattctta   Gtctgcctgg   Ctgaagaccc   Agactgttac   Cttgcctata   540     Ttcagtccct   Tctcactgat   Gaatggacta   Ttgactaggg   Tcctccttca   Agtcagaggt   600     Ctcctctctc   Ctcactcttc   Cctcagtttt   Aaagacaaat   Aatgaaagtc   Agaactttct   660     Gcaatgaacc   Accctcatcc   Acatacctgt   Ggatccttgg   Ctatcagctc   Caaggatgaa   720     Gccacacccc   Cctggacact   Ttgatctggc   Ttactggatt   Ttggattgga   Gaaataagag   780     Aaggtccatc   Caggagagtg   Tgctatctct   Aaagccagaa   Gaagagaaat   Ttttagggta   840     Agagccagtt   Ttcacgccaa   Tcagttcctg   Tagaaagatg   Aaagagaatg   Aagatggcca   900     Cagattgtta   Gatttggtaa   Gaagcaggtc   Acagtaacag   Tggagggaga   Tgatttcaat   960     Catgtggtag   Acctagaagg   Cagaatacag   Ggaattttat   Tttgaatgct   Ttttatagta   1020     Gagaaactca   Gataagaaag   Attcagtcac   Tatgaaacct   Tttattatagt   Ctgcctttag   1080     Gtacaaatca   Caaaaaatgt   Tcatagaagt   Tcatccagag   Agcttgtcat   Ctccttcaat   1140     Ttccttcttc   Ccgttcttta   Ttcttccttc   Tcttttctct   Tatacatcct   Acttacccct   1200     Tctcattttc   Aattacattc   Ctagtctatc   Ttaaatagag   Atacagaaaa   Agatcttact   1260     Aaaataacga   Aatctaaaaa   Taaataaata   Aaatacatgc   Caagtacttc   Tggggccaga   1320     Atgaagaagg   Gtgcaaggga   Gactccatca   Tcacccttag   Aaacatgaaa   Atcttaataa   1380     Acaatggtaa   Tagaaaactg   Acctacacag   Gccgggcatt   Gtggctcacg   Cctgtaatcc   1440     Cagcactttc   Ggaggtcgag   Gtgggtggat   Cacctgaggt   Cgggagttca   Agaccagcct   1500     Gaccaacatg   Gagaaacccc   Gtctctacta   Aaaatacaaa   Attagccaga   Tgtaatagct   1560     Gtaatcccag   Caactcaggg   Aggctgaggc   Aggagaatca   Cttgaactca   Ggaggaagag   1620     Tttgcggtga   Gctgagatca   Cgccattgca   Ctccagcctg   Ggcaacagag   Taaaactctg   1680     Tctcaaaaaa   Aaaaaaaaaa   Aaaagaaaaa   Gaaaattgac   Aacaggtgct   Ggagaggtag   1740     Tggagaaata   Ggaacacttt   Tacactgttg   Gtgggactgt   Aaactagttc   Aaccattgtg   1800     Gaagtcagtg   Tggcgattcc   Tcagggacct   Agaactagaa   Ataccatttg   Acccagccat   1860     Cccattactg   Ggtatatgcc   Caaaggaata   Taaatcatgc   Cgctataaag   Acacatgcac   1920     Acatatgttt   Attgcatcac   Tattcacaat   Agcaaagact   Tggaaccaac   Ccaaatgtcc   1980     Aacaatgata   Gaccggatta   Agaaaatgtg   Gcacatatac   Accatggaat   Actatgcagc   2040     Cataaaaaat   Gatgagttca   Tgtcctttgt   Agggacatgg   Atgagattgg   Aaatcatcat   2100     Tctcagtaaa   Ctatcgcaag   Galacaaaaaa   Ccaaacaccg   Catgttctca   Ctcataggtg   2160     Ggaattgaac   Aatgagaaca   Cgtggacaca   Ggaaggggaa   Catcacactc   Tggagaatgt   2220     Tgtggggtgg   Ggggaggggg   Gaaggatagc   Attaggagat   Atacctaatg   Ctaaatgacg   2280     Agttaatggg   Tgcagcacac   Cagcatggca   Catgtataca   Tatgtaacta   Acctgcacat   2340     Tgggcacatg   Taccctaaaa   Cttaaagtat   Aataataata   Aaataaaata   Aattaaaaaa   2400     Aaaaaaagaa   Aaagaaaatt   Gacctaaaca   Cacacaaaaa   Aactgaccct   Tttttgctct   2460     Cagctgtcca   Gtaggcagaa   Atggaaagag   Cagacaggaa   Ggatagaggt   Gagtcataga   2520     Gggcgggaat   Acacaatcat   Taagtgaaag   Ccattatcct   Caggaaggct   Cgagagaaga   2580     Gagtaggtgg   Caagagcagc   Agaattatct   Gaaaagccctc   Tggaataccc   Acttcctctt   2640     Tgctatggag   Aaacagggca   Tggcatgccc   Cacttctttc   Tgtttcaaat   Gcattccccc   2700     Ttctctaatg   Ggtgagactc   Taggcagcct   Ttaagatcca   Gttcaaaata   Cacccatcgg   2760     Atgacacctt   Tcctaacaga   Agccttcctg   Agcagagttc   Actgctctat   Cctctgggct   2820     Ctcgcaagac   Tcgtccatac   Atgtaagtcc   Actcaaaatt   Tgtatttgtt   Tatgtctatc   2880     Tgctggtcag   Gagctctctg   Acctctgtat   Cttggtgcct   Cctacagtgc   Ctgccacaca   2940     Gtaggtaatt   Aataactgtg   Tgagggagaa   Agaagagaaa   Gaaaaaagag   Aggcagtggg   3000     Gagagcagga   Tgggggaaga   Gagaaagagg   Aagcacctga   Ctaccttccc   Tggccaagat   3060     Aaagggaaat   Ggatttaaaa   Ataactctgg   Gggaaaggaa   Ctgaaagggg   Gaaatgactt   3120     Ttctgagtct   Tgtctgcttc   Tcactcttct   Ctccccccac   Atcctctcac   Cacttgagac   3180     Ctcaggcaac   Aacggtctca   Ttttcactcc   Tgattcctca   Gtttgcccaa   Aagaaagaag   3240     Gcacacaggc   Ttctgacttc   Ttccacccca   Tctccttaaa   Cctcagatca   Tctgtttttc   3300     Cactgtgggc   Ctctccctcc   Ttggcctctg   Cccccatcat   Ctttcccaca   Caacactcct   3360     Gccacatggc   Cctggggggc   Ccgtcaggcc   Tctcaggccc   Ctgtgccgtg   Catgtccatg   3420     Tgggagcttc   Tgcctcagaa   Ggaaaccaag   Aggttctcag   Gggcagcctg   Tggtgtctcg   3480     Ctgggaaacg   Ctagaccagg   Cctacaaagt   Tacccgggag   Agaatattgt   Taagaaggtt   3540     Taggcatccc   Aggggtggga   Gaggagaaag   Gagcaagttc   Caggaaaaaa   Agggctgaac   3600     Gatttacagt   Ccttactcct   Acactcctca   Aactctttca   Tggatggcca   Ttccacattt   3660     Ttcccatgat   Ccatgggtca   Gaaccatttt   Tccaactgtc   Ctcccatggt   Ctctacactt   3720     Tggctactga   Agcttcttaa   Ctctctttca   Aactagatgc   Cctttcccta   Agaatcccta   3780     Agccttgtgg   Agttgctccc   Gagtctcctt   Tcctcacctg   Ggtattcagc   Tgcctcccct   3840     Ttccctatat   Gttttcccta   Ggagttctgg   Aaccaccatt   Tcctcaacgg   Agatcatacg   3900     Tacaaaagca   Gtttacaatg   Cacagtgtga   Gaataaaata   Ctaccaagaa   Taaagcctct   3960     Tttcactccc   Cacaatctct   Gtccttctct   Caggctattt   Cttatgccct   Cctctcccca   4020     Tacactgttg   Ctccctcttc   Acccagcagg   Tttggtttgg   Tgtggggtgg   Gaaccaaagc   4080     Tatgtgctgc   Acagcgggca   Gtgtcaggat   Gcaggcaggc   Atctcagccc   Gaggccttgg   4140     Cagagttccc   Aggcagagcc   Atcggcccag   Gccaggacag   Taggcatgga   Taaggtgaga   4200     Gagggcataa   Gtacggtgac   Tgtagccccc   Gagcaccagt   Agctccccct   Gcagcacagc   4260     Acttgcagcc   Cccacatggg   Gggagggtag   Gggtgccagg   Tgagtccagc   Tatcagtcct   4320     Tagttcatag   Gcctcaaagc   Ttagcaggtc   Ctcagtctca   Cccagcccac   Ctgccacata   4380     Caacctccca   Cccaatgcag   Ccatgacatg   Gccagcccga   Ggtaccccca   Tagggctcag   4440     Aaacgtccct   Ggcttctcaa   Gtttggggtc   Arggtgcatc   Agtgaggcca   Ggtattggcc   4500     Agtcccacca   Cagccaccgc   Tcacgtacaa   Ctggccctcc   Aaaatcgcag   Ctgcgtgggc   4560     Aaaacatggt   Gctggaagtg   Caggtgctgg   Cctaagggag   Aacaggacac   Aagataaggc   4620     Aactagcatc   Ttcaactctc   Cttctattcc   Aagtctccta   Atctctccca   Gatgccccct   4680     Tgcctgctta   Cctccagaca   Ttgagctcag   Ggttgtaggt   Ctccacagag   Tccagggcaa   4740     Catcattgtg   Tcttccaccc   Agggcataaa   Gttttccatc   Cagtgccacc   Aaggagaaaa   4800     Ggcttcgagc   Ctgggacaaa   Ggagccatct   Cctcccagtc   Ctcttgactg   Ggctcccacc   4860     Tggacacagt   Aggacaagag   Attggaagag   Ggactctggg   Catccgtggt   Tggctaggcc   4920     Agcaatttct   Ctccctgccc   Accttagggc   Ctgccacacc   Ctgcccactc   Ctagaagct   4980     Atacctgaga   Gttgaagcca   Gggtgttgga   Gtgactgtag   Aaatcttgtc   Ccccacacap   5040     Atagagttca   Cttcctgcca   Ggcttgcagc   Cccatgccgg   Aagcgtccgg   Gggcaggcag   5100     Ggcaggcagc   Tgcccccact   Caacagttcg   Taccagtccc   Acgccacagc   Ggaaggcccg   5160     Ggcccaccac   Actgctcggg   Atggttgtct   Tagggccatg   Tctggtctga   Gcccatcccc   5220     Gccaatcact   Accagtgccc   Ggtcaggctc   Cctccgtctc   Tcttggcctg   Gaacatcagc   5280     Ctctaccatc   Agctggtgca   Acagatctgg   Ggtcaggggt   Ggaagtagcc   Cggctgcccg   5340     Caccctccgc   Aactccctgg   Tggacatgcg   Gccaaagcgg   Acacatcgca   Gcagggcctt   5400     Ggcctctgac   Tcctgggtct   Cggggttggc   Agccagccaa   Caccgtgcag   Ccacaaaggc   5460     Ctcaaactcc   Tcctgcacat   Ggagctcatc   Actatccagg   Agctcagcca   Agcaggcagc   5520     Tggtaaagaa   Gggaaagcag   Gacacaaggc   Tacagcaggc   Aggtgggtga   Ggaggtagtg   5580     Acgggctttg   Ctccagagcc   Tctccaaccc   Aggggcttcc   Gccatgggga   Acagggccag   5640     Gcaacgggca   Gggctgaggc   Cccgtgccaa   Gcctttctga   Cacaaatcca   Agcaggaaga   5700     Gctctggtac   Tgcagagcag   Cctgggcagc   Tctcagtagc   Cctggccacc   Ttgcccgcac   5760     Aactccggag   Taagcaaaag   Agacgaggag   Tcgcaggtcc   Tgggtggaga   Tcgtccgcag   5820     Agataccct   Gtgccctggg   Attccctcat   Cccgctcagg   Agcatggccc   Caaagaactc   5880     Actgccacag   Gccagggcgg   Ctcggtgcac   Tgcaggaggg   Gagaaggaat   Agaggaggac   5940     Tcaaagtatt   Gcaagaccga   Taggcattac   Cccaacttgg   Tactctaagt   Ttggccaaac   6000     Tctaagtttg   Gccctccaag   Cccacccactg   Ctacagacca   Aactgtggtg   Tgcatcagaa   6060     Taccatgggg   Tagttgttaa   Aatgcaggtt   Tcagcagtcc   Actcccagag   Attctgattc   6120     Agcagttctg   Gagggagacc   Ctagaaattt   Ggttgtaac   Acttcaagta   Accctatgtg   6180     Attctcatgt   Ttagggcctg   Aagacactta   Gataaacatt   Gctttagtct   Ttttggtcag   6240     Atgagtcaga   Aaaagagtct   Tcatggatca   Ggttgagagg   Aaagcatttg   Ctaagaggag   6300     Cacaaaataa   Atgggaaatg   Accaacaagc   Aacttatata   Ggtctgtcta   Tatcgtgaca   6360     Aaataaaatt   Ctttacaatc   Aagagccaag   Actgtcagcc   Attctgttag   Attttgctgg   6420     Gaaagtggca   Ccactcggga   Atggctgtaa   Tccaacctca   Tcggattgct   Gtctcctctt   6480     Gcctaagatt   Tagtgtttaa   Tgttttccgt   Gcgtcccagc   Ttttctctgc   Ataaccctct   6540     Cctgttcttg   Gtgtaatttg   Tagaatcatg   Agatctgaaa   Cttgagaact   Tcaaaataat   6600     Ctaattcaat   Tattcccttt   Aaaataagga   Aactggttgg   Gtgtcgtggc   Acacacctgt   6660     Aatcccagca   Ctttgggagg   Ctgaggtggg   Taggatcact   Tgaggtcagg   Agttcaaggc   6720     Cagcctggcc   Aacatggtga   Aactccatct   Ctaccaaaaa   Tacaaacatt   Agccgggcat   6780     Ggtggcaggc   Gcctgtaatc   Ccagctactt   Ggagactgag   Gcaggagaat   Agcttgaacc   6840     Tgggaggcga   Gggttgcaat   Gagctgagac   Tgcgccgctg   Cacccagcct   Gggtgacaga   6900     Gcgagactcc   Atctcaaaat   Aaataaataa   Ataaaatgtg   Gaaactgagt   Tgggtcccaa   6960     Agaaagcatg   Tgatttattt   Ttcatttcca   Tgcagtggct   Gtgtgggcag   Atcatctcca   7020     Tccactgcca   Ctgatgtcag   Gctgcaataa   Gcatgcttgt   Gtaccaatac   Cttggttatc   7080     Tgcatggtcc   Tcatgacaat   Gaaactgtcc   Tattaaccta   Cgctgttaaa   Caattagacc   7140     Tcatactcag   Catcacttat   Ggattattct   Ggccaaaata   Tttaacttga   Atctgttcaa   7200     Ctctttagat   Ctaaagtcaa   Gtttatagga   Agttgaaagg   Ctaaaggaac   Aatttagagg   7260     Ggaaaaacca   Cacaaatcaa   Gaaaatggag   Cattttatag   Gataaccaat   Tttttttttt   7320     Ttgagatagg   Gtcttactct   Gtcaccctgc   Ctggagtgca   Gtggtacaat   Ctcggctcac   7380     Tgcaacctcc   Accctccagc   Ttcatgtgat   Tctcgtgcct   Cagcttccag   Attagctggg   7440     Actacaggtg   Cacgctacca   Tgcctggcta   Atttttgtat   Ttttagtaga   Gacggtttcg   7500     Ccatgttgga   Caggctaacc   Ttgaactcct   Ggcctcaagt   Gatctgcctg   Cctcggcctc   7560     Ccaaagtgtt   Gggattacag   Gcgtgagcca   Ctatgcctgg   Cccagggtaa   Ccaatcttac   7620     Atgttattgt   Ctttaccaat   Caatatataa   Agtaataaaa   Aaaaaaaagg   Aggaaggact   7680     Gtactagatt   Aaaggaagct   Taagagacat   Gcaactgaga   Atagcatagt   Ccttgattaa   7740     Ttcctgggtt   Gaacaaactc   Actttaaaaa   Atgttttttg   Gacaactggg   Aaaatataaa   7800     Tgtggactag   Gtgatattaa   Aaaattactg   Gccaggcgcg   Gtggctcatg   Cctgtaaacc   7860     Cagcattttg   Ggaggctaag   Gcaggtggat   Cacctgaggt   Caggagttca   Agacagacc   7920     Agccaacatg   Gtgaaacccc   Atctctacaa   Aaaatacaaa   Aattagctgg   Gtgtggtggt   7980     Gcacgcctgt   Aatcccagtt   8000       <210>   82   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   DPP6     <400>   82   Cgtttgcgaa   Aatgttgata   Aatataggac   Caccttcgca   Tccctgtttg   Tgaaactgtt   60     Gataaatata   Ggaccacctt   Cacatccctg   Tttgtgaatg   Caatagcaca   Gaagaaaagtc   120     Attttgagga   Tgggataggg   Aatgaacttc   Tgatggtaat   Gctgtcttca   Aatggttccg   180     Aattgaattt   Tatcagaaat   Ttaaataccc   Aaaattaata   Tagaaattga   Gaaccatctt   240     Atgttaagca   Ctttttcctt   Acacttactt   Tccttctttt   Cctttttttt   Gttctttttt   300     Tttgagacag   Agtttcgctc   Ttgttgccca   Ggccggagtg   Caatggcaca   Atctcggctc   360     Accacaacct   Ccgcctcccg   Ggttcaagca   Attctgcctc   Agcctcctga   Gtagcttgga   420     Ttacaggtgt   Ccaccaccat   Gcccagctaa   Tttttgtaat   Tttagtagag   Acgggatttt   480     Accatgttgg   Ccaggctggt   Cttgaactcc   Tgacctcagg   Tggtccaccc   Gcctcggcct   540     Cccaaagtgc   Tgggattata   Ggcgtgagcc   Accgcacctg   Gacctgtctt   Tcttacagag   600     Acctcttagc   Ctcattcttt   Tcctctccag   Tattccatat   Ggcagtggct   Caaggtagac   660     Acgttgcaaa   Gaatgaacag   Gcattacctg   Gatattcagg   Attgctttgc   Tgttttattc   720     Tgtgcagtgt   Ttccttttat   Gcctgctttt   Cagccctatc   Ctttctgcag   Ggctctgggt   780     Cacaagctgg   Gcaggaggag   Cagaacacag   Cgcctctaac   Aagtagcagg   Actggacgct   840     Gttggttaag   Tgttaggaga   Aaatgtgtct   Gctaataggg   Tttattgttt   Ctttttttgg   900     Gggaattttt   Attttttatt   Ttttatatat   Aaactttaag   Ttctagggta   Catgtgcaca   960     Acgtgcaggt   Ttgttacata   Tgtacacatg   Tgccatgttg   Gtgtactgca   Cccattaact   1020     Cgtcatttac   Attaggtata   Tctcctaatg   Ctatccctcc   Ccaattcccg   Caccccacaa   1080     Caggccccag   Tgtgtgatgt   Tccccttcct   Gtgaccaagt   Gttctcattg   Ttcagttccc   1140     Acctatgagt   Gaaaacatgc   Gttgtttggt   Tttttgtcct   Cgcaatagtt   Tgctgagaat   1200     Gatggtttcc   Agcttcatcc   Atgtccctac   Aaaggacatg   Aactcatcgt   Tttttatggc   1260     Tgcatagtat   Tccatggtgt   Atatgtgcca   Cattttctta   Atccagtcta   Tcatgttgga   1320     Catttgggtt   Gtgggactgt   Aaactagttc   Aaccattgtg   Gaagacagta   Tggcgattcc   1380     Tcagggatct   Agaactagaa   Ataccatttg   Acccagccat   Cccattactg   Ggtatatacc   1440     Caaaggaata   Taaatcatgc   Tgctataaag   Acacatgcac   Acatatgttt   Attgtggttg   1500     Tttcttaaca   Taaaggttta   Atccgtatga   Ttccacttct   Gatttccagg   Gataatttga   1560     Aggaaactat   Aaaaatagaa   Ggttaaaaaa   Tatgtttgtc   Ggccgggcgc   Agtggctcac   1620     Gcctgtaatt   Ccaggacttt   Ggggaggccg   Aggtgggcag   Gtcctctgag   Gtcaggagtt   1680     Tgggaccagc   Atgaccaata   Tggtgaaacc   Ccgtctctat   Taaaaataca   Aaaattagct   1740     Gggcgtggtg   Gtgggcacct   Gtagtcccag   Ctacttggga   Ggctgaggca   Ggagaatcac   1800     Ttgaacctgg   Gaggcggagg   Ttgcagtgag   Ccgagatcac   Gccactggac   Tccagcctag   1860     Tgacaaagca   Agactccgtc   Tcaaaacaaa   Aatatatata   Tatatatata   Tatatatata   1920     Tatatgtttg   Tcttcttgat   Ttttcctctc   Ctccatcatg   Tggtgatggg   Atgggaaaag   1980     Gcaggttgtg   Gggagcagtt   Tggaggccca   Tgcttggtgg   Gaaagagagg   Gaggaaaatt   2040     Ctagatgaac   Gaatgccgct   Tcaaaggaag   Aagcaaaaga   Accatattaa   Ccctgcttac   2100     Aatcggattt   Agattggtga   Tatattctgt   Ccacactcaa   Ctgggtttat   Cctgacattc   2160     Aacagtgtaa   Gtgacctgta   Ctctaagtgt   Tcccttcttg   Agaaaaggtg   Tgattgagca   2220     Gcctgctgtt   Gtctgaattt   Ttgtctctcc   Cttttccaga   Attcatatgt   Gaaacctaac   2280     Cccagggtga   Tggtgttagg   Ggctgaggac   Tttgggaggt   Gatgaggtga   Tgagggagga   2340     Gccatcaccc   Tgataaaagg   Gaccccagag   Aggtgccttt   Cctcacacca   Tgtgatgcac   2400     Actgagaagg   Cgccatctgt   Gaaccagaaa   Tcagattctc   Accacacaaa   Gcatctgctt   2460     Gcaccttggt   Cttggacttc   Cagcctccag   Aactgtgaga   Aataaattcc   Tgttgtttat   2520     Aacccacgca   Ttttacacta   Ttttgttatc   Acagccagaa   Gacagtaaga   Caaatcccaa   2580     Cagagaagag   Tgcttctaga   Acctaaagtg   Cacctaccac   Tttctagcaa   Agcctgatcc   2640     Acattacttt   Aaaagtgact   Tttcaagcat   Tttgctttgg   Tttacctatt   Tcttccactt   2700     Acctctctca   Agcccaaatc   Attagtttac   Acttgtaacc   Aattgctcgt   Gcacatgtcc   2760     Taatgttttt   Gaatatacat   Atattaatac   Ataatgtatc   Attcgtgttt   Gcatgtgggc   2820     Attgtggata   Acttacatgt   Aattacagtt   Gcaattactt   Agaatcatct   Acttcttcat   2880     Gagctcgaaa   Gtgacctctt   Attctttttt   Acaaacgag   Atttttttgt   Gaatgtaaat   2940     Aatggaaaag   Cttcccaaac   Ccctcccaga   Ctccagctcc   Cgccatgccc   Ttcccctcag   3000     Gcgctggcac   Gcccttacac   Acacacacac   Acacacacac   Acacacacac   Acacacagcc   3060     Tgatgtgtct   Atcagctctg   Aatctggttt   Ttcaagtggc   Ttgggtgggt   Ctgcatatga   3120     Atttgaccaa   Cctctgcgcg   Cgctcctggg   Agcgcgcatc   Tgtgtgtggt   Ccagggagcc   3180     Aaccgcgttt   Gtgaatggat   Gattgatggg   Aacagcgccc   Aggggcagca   Ggtggagacg   3240     Ggaacccagg   Tcgcggtcac   Tggtcaaccc   Gcctcttggg   Gtggaggtta   Gagaaatggg   3300     Cgctgggatt   Tggccccggc   Cagtgctggg   Gttccagggt   Agggagagcc   Gtgggcgcca   3360     Gactgggctg   Cgggaggtct   Tcggggtcag   Atcccgcagg   Cagccaagag   Cgagccaaag   3420     Aaacaaagcc   Gccgagggac   Gcggctgggg   Cggaggcccg   Gagggaagtg   Gaggccggga   3480     Agccaggtgt   Gcggcgggga   Gaggggcccc   Tgccacccgc   Gctggtagcc   Gggcgctgcc   3540     Attcactgca   Aggtcctctg   Cgccctggaa   Ttgccgcggc   Ggcggatgca   Gaggccaacc   3600     Cagagtgcaa   Ccatggagac   Gcgacgtgtg   Tcccatagta   Acctgttaca   Acattattta   3660     Taagctgcca   Tccctagcct   Tcccccgctt   Cccctccgct   Ccctcgccag   Acttgcgggc   3720     Gacgggcaca   Gccgcgtctg   Gctcttcccg   Gcctctccct   Tctctcgcgg   Gcgcagccga   3780     Tcaatagtta   Acacccggct   Gcggacggcg   Gctccatccg   Cggcaatcac   Cgtagtgctt   3840     Gtttgtggaa   Gccgagcgtg   Cgtgcgccgc   Gcgcgcaccc   Agtccagcgc   Ggagtgggcg   3900     Tctacccgag   Gaggggtgtc   Tggggagggg   Ctgccctcgt   Tacccaaaca   Gtttgcgctc   3960     Gcttaacctt   Gatgcagctc   Gaggcttccc   Agtccagctc   Agttcagaca   Gaaaacctgg   4020     Cgcgcgcgcg   Cgcacacaca   Cacgcctccc   Ctggcgtcgc   Cgcccggccg   Ggtccctgcc   4080     Cttagggacc   Agagcggcga   Ccgctgcacc   Ccgcaccgcc   Tgctggagga   Gcccccggag   4140     Ccggggccga   Gccgccggcg   Tccccgagtg   Cgccccctgt   Gcgtgccgcc   Gcgctgttgc   4200     Tcgcagtgtg   Ctggcgccga   Gctcggtgga   Cacgcgcgca   Gtcagagctg   Cctctcgccc   4260     Tcgctagctg   Ggctcgcagc   Ctcttcctcc   Ctccctggct   Cctggctttt   Tgtttaaagc   4320     Aacacccacc   Ctccatccag   Gctttttttc   Tttctttctt   Tattggtagc   Ggccaaaaag   4380     Agttgattgc   Tattgggatc   Cgctgagtaa   Agacacgggc   Aggggtgcgc   Ggaggtgaga   4440     Aaactgaaga   Cctggaagat   Ttttttttcc   Ttcaaaaacc   Cgtttccatc   Cagtcttcag   4500     Ccagtccagt   Ctactttaat   Cctcaccagg   Acaatggatt   Aagtttctct   Tccctggacc   4560     Gaagagtcggg   Ttcggacttg   Gggcaaaatg   Aaggaaaagg   Ccatgatcaa   Gaccgctaag   4620     Atgcagggga   Acgtgatggt   Gagtgccacg   Gacagggcgc   Gcgctgggtc   Ggggggaccc   4680     Accgtgagga   Gcgatgctgg   Gggaggtctg   Tccttctcag   Tcccgaacct   Ccctggaagg   4740     Acagcgaccc   Catgcccgcg   Cgcggcggcg   Cttctcccac   Ttcccacccg   Agcccaccca   4800     Gcggcagggg   Gatgcggagg   Agcaggcatt   Tctttgcaaa   Ttgcaacttt   Gcggctccgc   4860     Ggcccctctc   Cttcgggcat   Gtggctttgt   Gttttgggcg   Cgggatggga   Ggaaggggct   4920     Gcggggagcc   Ctcgctgacc   Gcgggtcggt   Ccgagcccca   Agcagacccc   Cagggctctt   4980     Ctggggaaac   Gcggggagag   Gtggtcactt   Cggccaggga   Agggccactg   Ggccctggcg   5040     Cccgcgccgg   Cctcggtgct   Ccgagtcccc   Ggaactcgag   Acctgttggg   Tctgcggagc   5100     Cttcggtgct   Ctcggggcag   Gcgccagtcg   Ctccgctccg   Ttccagacgc   Cgccgccggg   5160     Cgggaccctg   Ctccctggat   Tggggacgct   Gactccccca   Aaagcttgac   Tgtgccggag   5220     Gaggtcaggg   Gcacttcgtc   Ccccaggagg   Gccgcgtgcc   Tggaaacgcg   Gctggtccgc   5280     Ggaaggctcc   Gggcagctgg   Ccaggggaca   Gttctgcacg   Gataactttc   Taagtggagg   5340     Acccggcgat   Ccgcctcccc   Agcgagccca   Cccgcctcgc   Cgctccccgc   Tgacccgcgc   5400     Ggcctgggcg   Cgcctgctct   Cgggctcacg   Ttagtccggg   Gcacggggcc   Gaggggtcag   5460     Ggcgctggag   Tctctggcga   Ggacgagaga   Gttgccatct   Tgttctgttg   Aaattgtttg   5520     Tgtgccttcg   Tgtgtttatt   Ttaacccatt   Aggtcatggt   Ctgagaagaa   Tcctctgacg   5580     Gtcccttatt   Ttaagttgct   Ggctggcact   Tttttttttt   Tttttttttt   Ttttggcgac   5640     Agacaaggag   Atggggattg   Ccttgctact   Tttgaaggtt   Ctgcagattt   Gcagatgcta   5700     Cttttgaggg   Ttccgtaaga   Attgaagaaa   Ttctttcagg   Ggcaaggtcc   Agaggtgttt   5760     Acagaagtgg   Gttgggtcca   Agtgatgggg   Gtgcagaggc   Acctttgcgg   Gaacccaggc   5820     Agtggtgcat   Tttgagatct   Cgctttaagc   Aaaacaggca   Ataagtgaaa   Aattctacat   5880     Taattgaaca   Aatacccagc   Tggcttaacc   Acacccacgg   Cagacacctg   Ttgcctggca   5940     Gagagaagcg   Ccgtgggttc   Gaaacttgac   Tctggacgga   Ggtgtgagtc   Tctgggttca   6000     Agacacctcg   Cagggaagta   Atcgccgcat   Ggaggggctt   Actcttcagg   Accctcccca   6060     Ctcccgagac   Gacaagcccc   Catctagggg   Cggttcgcag   Tcctcggtcc   Gtgggttctc   6120     Tgactgacct   Aattgcttgt   Tttagaaaat   Gcatctgctt   Ccctcatttt   Tcccactctt   6180     Tttctttttt   Agccattgtg   Ttgttcagca   Taatttcttg   Cataacaagg   Atagaaacgt   6240     Gtataggagta   Atgctttttc   Attaatgcc   Caaccacatc   Catcattcct   Aacttacgtg   6300     Atgccatcat   Gtgctaggga   Aacctgtata   Tttagggctg   Aggctgaagt   Taaggattga   6360     Ggttaattat   Actgataagg   Caacattatt   Gactcattac   Atcaatctac   Cgccaaataa   6420     Gtttctactt   Ataacttgca   Tggcatgaaa   Gagccaaatac   Ttcatattac   Acctttatta   6480     Gaaaccttat   Ggtctttgcc   Ctccccctaa   Cccctctctg   Cgttttactt   Cagaaaataa   6540     Agaatgaaag   Gattgctaat   Tacatttctc   Tcttctgctc   Tgaataagga   Tattccatgt   6600     Gatactcatt   Gcatcccttc   Ccctgtgtct   Aatgttaaga   Agtgtcatcg   Gagcaaggtg   6660     Aacctgagcc   Tagagaattc   Tacagcaacc   Catattttca   Gagttatttg   Tgggcccaag   6720     Aaaacaatga   Gatgcacact   Tactcaaact   Ttgaatgttc   Tttacaattc   Ttgaattgat   6780     Aattatggct   Ccacaggctg   Ctgtgtaact   Tatttgaatt   Ttcatgttcc   Aaggaaatcc   6840     Acgtggcttc   Agttgagtga   Tcatttagga   Cttacccatg   Cctaatctct   Caagttgctt   6900     Tggaagactc   Ttgctaatca   Cagcctctct   Tggattagat   Gactggcaaa   Ttctttgcac   6960     Tcacaacttg   Attgaaattc   Aggtgatatt   Ttacattcaa   Gatgaggact   Gaatgattta   7020     Ctcctattac   Tgacagctga   Gctgccgcac   Atctgacagc   Tacaaaaagt   Ggcagaatgt   7080     Tttctacttt   Gcagtaacag   Tgaacccaca   Tacacacaga   Gaccagatct   Cagttcaggg   7140     Gactcaaaga   Tctctgagct   Gtctggactc   Gcatttgagg   Tttgatattt   Aaaaaagaga   7200     Aagacacttt   Gcactgccca   Aatggtcacg   Gaaatgtcaa   Atccagttca   Gccatgcctg   7260     Taaactgctt   Tctaatccag   Cccctgctcg   Ctgacatcca   Cattgtatga   Ttgttctgga   7320     Cctgcagcct   Gttgtttcac   Cgggagttct   Acaagaatgg   Tgacaatagc   Ctcccggctg   7380     Gtccttgcca   Tgccacattg   Cttagttgaa   Agtatgttct   Tataaaatct   Ttaaaaaatg   7440     Ttttattcct   Cacatattgc   Tttaggaatt   Tatttctgag   Tacagctaga   Ggattaagag   7500     Aaggcagatg   Caccagcata   Ctatctgatc   Ttgttttgtt   Ttagtaaatg   Ggtaaaagaa   7560     Ataccacagg   Tggaatcagt   Ttagaacttt   Tttttttttt   Tttttttttt   Tttggagaca   7620     Gagtctcact   Ctgtcaccca   Ggctggagtg   Cagtgcagta   Gcgcaatctc   Agttcactcc   7680     Tcccccaggg   Ttcaagccat   Tctcctgcct   Cagcctctcg   Agtagctggg   Gactacaggc   7740     Gtgcaccacc   Atgcctggct   Tttttttttt   Tttgcatttt   Tagtagagac   Ggggtttcat   7800     Catgttggcc   Aggctggtct   Tgaacccctg   Acctcaggta   Atctgcctgt   Ctcggcctcc   7860     Caaagtgctg   Ggattacagg   Tgtgagccac   Catgactggc   Cagtttagaa   Cttctatttt   7920     Aatttttttt   Tttttttttt   Tttgagatgg   Agtctcactc   Tgtcacccag   Gctggagtgc   7980     Agtggtgcta   Tctcggctca   8000       <210>   83   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ADCY8     <400>   83   Agacttgctt   Gaggcagggt   Tgccacaaac   Cttcaatttg   Taataaaatg   Caatatctgt   60     Gaaatacata   Aagtgaagtg   Aaataaaatg   Agatatttct   Gtattagata   Cgtttcccac   120     Acttttcaag   Tcttacaact   Tcgggattct   Aaatcacaac   Aacttccttt   Ctgatgccca   180     Ggtggtaggt   Aaagagtctg   Gggcacacag   Aggtcctgct   Gcatgcccag   Catcaaacag   240     Ctggtaagtg   Ataaatatag   Cattcaaacc   Aaagcctgtg   Cacctcaaga   Aactgcctct   300     Gagtagttag   Cccagtactt   Tctgaccttt   Ttcatctcac   Aggacagaaa   Gaaaataaaa   360     Atcgctgttt   Aacccattgg   Gggaagagga   Tgaagctgtt   Tgggatcagg   Acaagtggcc   420     Ccaggctgtc   Tgaatggctg   Tcattccaga   Gtttttcaca   Gcttacccat   Tcacacagcc   480     Tgcagcatgc   Aagtggggag   Tctactcaga   Catccaactt   Tcatttaatg   Aacattattc   540     Acccccttac   Aagcttcaac   Agtggtgttt   Aaggacagga   Ctcttgagct   Agacacctg   600     Gctttgaatc   Cctgttttcc   Agttgctaga   Cctgtggtga   Gttgctcaag   Ctctttgtgc   660     Ctcagtttcc   Tcatttgtaa   Aatggagatg   Acacacatagt   Tgtaacttcc   Agtggaaagc   720     Agctacactc   Ccatggttcc   Taaagaagga   Aggaattggt   Gaaactggtg   Tgggggcatt   780     Tctgagctcc   Aggtgaccca   Cctggcttta   Tgtgatggca   Gattgtgagg   Cagcagctcc   840     Tcaaacccag   Tccttgaatg   Aaagctaaag   Ataccttgcc   Caatctctag   Gcaaggctgt   900     Gcttgtctca   Cgggagactg   Tgcttttcct   Acacaggctg   Atgaatggtg   Ggggcaccca   960     Cctggatcag   Cttccagaag   Agtaagtcaa   Aaatacagag   Tttatgagaa   Agcctcaact   1020     Aaaccttatt   Gaatttctcc   Ttgtatttca   Gcatttcggg   Caccattccc   Ttggcatgtg   1080     Tttatccttg   Acatttctaa   Aatcaaaccc   Cacatctcac   Aggcatagtt   Cagagcagga   1140     Aaaggtaaga   Ttgatatccc   Tgtctaaaat   Actatgccag   Gtttcccaga   Aatcacttga   1200     Catttcaggt   Tcttttacta   Agtgagctga   Atggaccaaa   Aatgtaggca   Aacagaaaca   1260     Tacttctaat   Tcaggaagat   Cgtgtgcctt   Catgtccccc   Tccggactca   Tgcaaggccc   1320     Aagaagaggg   Ttgttttctt   Agctattcaa   Ccataagcca   Gtttatggtt   Ctgtctcttg   1380     Tccttttgcc   Ttagtatgga   Aagaccacat   Ctgctggttc   Caatgaatgt   Gctgatctag   1440     Agggaaggga   Ctcaacgttt   Tggtgctggg   Tgaattggag   Tagaggccag   Atgcccactt   1500     Gatgggctcc   Ttggcaatct   Gatgagaatt   Ctcagcatca   Tcatgtcccc   Ttgctcctct   1560     Atttcctgga   Gtcctgaatg   Aagtcacacc   Tcccagaccc   Agtagggagt   Gtccacctcc   1620     Tccatatgtt   Gtatcttgag   Ggttgacatc   Attgagtcag   Gaacaggttc   Tgggtgaagc   1680     Tttacagtgg   Taaccccact   Gtcaccccca   Aattggtggc   Atccacatgc   Ctgatggttc   1740     Ttccttagt   Ttctgcccag   Tttacttgcc   Tagggccaag   Ttcttctagt   Ccagggactt   1800     Tgtcctgagt   Cctagctcag   Ggtttagaaa   Cgaagtcttt   Ccctactagc   Ctctcttctt   1860     Gggggtagat   Ccagctcacc   Atggcttgtc   Tgcctactgg   Agtctctgtt   Gatactggct   1920     Gtggttttga   Gatgggcctt   Atgctctggg   Gtagacgaga   Gcttgatgat   Ctacatcaag   1980     Ttttctgttt   Ttcagatacc   Gtgccttcac   Agcctaacta   Cctttgtgag   Gccagccttt   2040     Ttgctagctt   Tgtttgccaa   Gcctcgacct   Acctgagctc   Agctccccac   Ctgcatctgg   2100     Tggttccaag   Tctcagcagg   Catgaagctt   Tactttgttt   Aaatgtcctc   Agtctgttgg   2160     Actgaacaac   Ccatggggct   Ttcctgacct   Cggattctct   Gagtctatga   Agattgtaac   2220     Agcctctggc   Attggtagag   Ggatttacag   Tatgctgagg   Cttttcactt   Gtcatcttca   2280     Cattcctttg   Gggccttgca   Tgaatttgga   Gggggcatac   Ttctttgatg   Tgtatatcgt   2340     Ttcctagagc   Aaacagcatc   Ccaaatgtgg   Ttcaaagttc   Aaggtttacc   Tgaatcaatt   2400     Ccctctctgc   Tttgtgcctc   Aagagaagac   Agcttcactt   Ctaacattag   Ggtcccactt   2460     Gagatgcctc   Aggtagatgt   Ttttttgagg   Gtatatctac   Tgtggatttg   Ttcctgggg   2520     Ctaagtttct   Tttaaatggg   Atggtgttca   Gagtcaagtg   Tttagagaat   Ggttgggatt   2580     Ttataattct   Catcaatta   Cttaaacctt   Gtaccctcaa   Catagcgctt   Atcagaatag   2640     Cttagtgttt   Ataaacatgg   Actctgggct   Cagaaagact   Caggtgcctg   Tggcataggc   2700     Agttacattt   Cacttttcct   Tttggtaagg   Gaacacagga   Atcatccatt   Ccctaacttc   2760     Ccctgcagtg   Aggtgggaca   Gaaagatgat   Gtatgcctgg   Tagctgagac   Cttctaagtg   2820     Attcttgttt   Ctttcccttt   Tttctcctca   Gatggctgga   Tagagagggc   Caagaagaga   2880     Actccaatgc   Agaaggaggt   Taggcttccc   Aaaaattgca   Caggagaccc   Cttgacacat   2940     Atccaataga   Acataagcaa   Gaagtacatc   Ttttattgtg   Ttttagccac   Taagattggg   3000     Agttatttgt   Tatagcagtt   Ggcttttatt   Gaacaatata   Gttatgaagc   Tagttctaca   3060     Actaactaca   Tgaccttggc   Caaatccttt   Aatttttctg   Ggctttctca   Cctgtatgaa   3120     Attttcctgg   Caatcttgtg   Gtcataagca   Cgtaggtgtc   Ttccaggaaa   Cagtgtgctt   3180     Gcccacagta   Gctcacttac   Ccattgcctt   Tctcattgtt   Cctccaatgt   Gccggacttg   3240     Atacccctct   Gggctttcgc   Acttgctgtt   Actttttctt   Gtgaaacttt   Tctctcaggt   3300     Cttatgggtc   Acctctttct   Attatttagg   Gccaatcatt   Gacatcacat   Cttcaaaaaa   3360     Gccttccctg   Gtgactcagt   Taaatcagca   Tccctgtcct   Cccattcttt   Atcccaagtg   3420     Gccaacttaa   Ttttctttgt   Tgcctctacc   Tctatctgaa   Agcagattat   Tatcccaagt   3480     Ggccaactta   Attttctttg   Ttgcctctac   Ctcaatctga   Aagcagatta   Tttatgtatt   3540     Ggttaataag   Aatattatat   Attattcccc   Aaccagaatg   Ttagctctat   Aagggaaaca   3600     Cttttgctag   Gatttccctg   Gaggatagga   Cagccatatc   Cacattgtag   Ttgctcagca   3660     Aatactgatg   Aacgtactgg   Tcaagtgctg   Tgaggattac   Aggaggtcat   Tatgtaaaaa   3720     Atttggcgct   Tggcctggca   Catggcaagt   Gctcaaaaat   Agcagatggt   Ggtgagtatc   3780     Tgactgtatg   Gagtttctgt   Tcacttcaca   Tgtcccactc   Ttccacctag   Ttgtaagtct   3840     Ctcaaactct   Caaagtcaga   Aactagatct   Catttatctt   Tgcctcccaa   Taaaccttgt   3900     Acacaagagg   Tgaccaataa   Atatttgtga   Agggaacatt   Tgaagagaat   Ctcaaattgt   3960     Gtccttgatc   Tggtacattc   Aaagaccaac   Gaaaccatcc   Ttgttctaaa   Aaaaattaaa   4020     Cctttttatt   Agtatattta   Ttttatatat   Aaaagaaata   Caaaaaaaaa   Aaacagaaag   4080     Aaaatgcttt   Tatggcaaat   Cagatttgtc   Ggtgccttca   Gcctgggctc   Caggctctgt   4140     Gccgctgggt   Galacaacaag   Tccgccggtt   Gtaatgaccc   Ttgatgattc   Ctgtgttgtt   4200     Gttctcattg   Agtagctgct   Tctgcctttg   Cctattgagg   Gactggacaa   Gtcccaggac   4260     Aaccgcggcc   Agggagtact   Gcccaggcag   Tcttcttggg   Ggcaagatga   Atgggttggg   4320     Ttggactctt   Cccagaagaa   Agtacgttt   Gatttttcct   Tcctgttcac   Tgataccctt   4380     Cacatagatc   Tcccctcggt   Aatcaaaggc   Aaagccctgg   Tccttcagga   Tgagataggt   4440     Ctcctctggg   Acttggatcc   Ggccactaac   Ccccgtgctg   Tccattcggc   Ttgccaggtt   4500     Cacagttttg   Ccccaaatgt   Catactgtgg   Tttcttagcg   Cggataacgc   Cagctaccac   4560     Tgagccgtgg   Ctgatgcctg   Gggggtgaag   Caaaggagca   Gaagagtcaga   Gggagaaggg   4620     Ggacaatggg   Gtgtttggac   Ccctccctgg   Gacagtgatc   Actatgtgtg   Gggtctctgt   4680     Ggatgaacgg   Gagggtccag   Atcctgcccc   Cagtcactta   Ttagatgtat   Cacctgggtc   4740     Agttaattaa   Cctatttgga   Cctcactttt   Ctcatcagta   Gaatggaaat   Aattaaaggc   4800     Agatttaatg   Agatataca   Agtaaagcca   Ctgtggcatg   Gtgcctggca   Accagtgagt   4860     Gttcaattga   Atataattat   Tattgtcata   Tgagcactga   Cttgtcttag   Tctgtgagat   4920     Gatcagagca   Tggaccagaa   Gtcaggaccc   Taggatctcc   Tgcttctgct   Gacacagtgc   4980     Tctgagagcc   Tgcacaggcc   Ttttccctct   Ctgttttagc   Ccaggtcctc   Agcatcattc   5040     Cctgtgcca   Tggcgatggc   Tttctaactg   Tcctccctgt   Ctcctccctt   Gttcccttga   5100     Gctcatcctc   Cacactgctg   Caggagcggg   Agggctcgtt   Ctgatcaagt   Tgcatatctg   5160     Atcaagttac   Aacccactta   Aatatcttcc   Agggctcctt   Tcacttacag   Gataaagcca   5220     Atgatcctta   Gactcacaat   Caataacctc   Tctgatatgg   Cttttgcctg   Attttccagc   5280     Ctcatttatc   Ccactctctt   Ccttactgct   Gcattatatt   Cacactgaac   Tgctggagtt   5340     Ttcctaacct   Tccagccagt   Acccaccttt   Gtgcctttgt   Cctgactttc   Cccctgcttg   5400     Tgctattact   Tccccacact   Ttcacagttt   Atctggtaaa   Tacttttaaa   Gacagtttca   5460     Gtgcctcctc   Cactaggaag   Catagaattc   Tagaaatggt   Agcatttcac   Taaacctgtt   5520     Agtgggcatg   Tatgtctctt   Tctaaaagac   Aattatttca   Ttctacaaac   Attgactagg   5580     Cacttgctat   Gagccaggta   Cagtcctagg   Cattggggat   Gtggtgggaa   Aggaaagaaa   5640     Tacagccctg   Gtccccatgg   Aatttacctt   Ctactgggga   Gagatagaaa   Ataattttac   5700     Aaatgtaata   Taatattaat   Gaatgattag   Ggctacaaag   Aaaaatcaat   Gagggtaaaa   5760     Taatggagaa   Agatggaaga   Gagtatatct   Cggagtaagg   Aggttagcaa   Agacttgtt   5820     Gagcagagaa   Tatggtggga   Atagccatgc   Agatatctcg   Gtaagattat   Tctaggccga   5880     Ggcaaaagca   Agacacgtat   Acccactgat   Ataagtgact   Ggaaatttga   Aaatctcact   5940     Ctataggagta   Catgggaatc   Acaatgatag   Ttagctcttt   Aaaatttgca   Gagaactttg   6000     Acagccaata   Tcccatttga   Ttctcatatt   Attattgtga   Ggtagagagg   Cagaggaggt   6060     Aataatttaa   Cacccagctt   Acataggagg   Aaacggagac   Acagaaggtt   Taaatgattc   6120     Acccaaagtc   Atacagctgg   Ttacagcaga   Cccaaaacac   Aaattgagat   Gcttaattca   6180     Gttgggaagt   Taattttcca   Acctctgaga   Tcagtgaaac   Tatactacga   Gtgtaatatg   6240     Tcatggcaag   Ggttgaccct   Gatttggcaa   Catcttcaga   Atttacttag   Aatatctctg   6300     Ttcagcatta   Cagttccctt   Tttattcctg   Gttcaattgt   Gtagtcaaca   Atttcagaaa   6360     Tgacattgat   Aagattgatg   Gaagatgtgg   Gaacaagcgc   Tgaacatccc   Atccatagat   6420     Caaaaacata   Aaatataagc   Cctttaatgc   Aaagagcaaa   Gacatatggc   Attccttaga   6480     Tctgacaagt   Cagatattgg   Tatttcttga   Cctgtttttc   Ttgaaagctg   Ctaagggaga   6540     Agcagataaa   Gtaaaatggc   Atatcagcca   Gaagatgtct   Acagtgtgag   Gaccgtagca   6600     Aaagttattt   Taaactgcac   Tctggcagcc   Agaatgtcat   Tgtctcagag   Ttaggaaatg   6660     Ctggagctgc   Tgctggtgtg   Actgtgtgat   Cttaggctag   Ttactccctt   Ttcataggcc   6720     Cgcatttact   Catctacaaa   Atgagaatgt   Ggactagacc   Agggatattc   Agactgcatt   6780     Ttaggaggtc   Actgaggctc   Agtagagatg   Tggaaggaat   Ggcaaatata   Aaggattatt   6840     Attgattgca   Gtgattaatg   Ttacgttgtt   Gctttgtgcg   Gtgatgtctt   Taagcccaaa   6900     Gaaatggcga   Gctttgtggc   Tgagtaaagc   Ctgtccctgg   Aagtatagta   Tctgccatcc   6960     Tcaggagtag   Aatcctgctt   Ttgtctgaag   Gaattatcct   Gaagaccttg   Agagcaatac   7020     Attgaccacc   Agcattgagc   Tacccaggag   Tcagaattaa   Atgactgatt   Agtcagctac   7080     Atctctatgc   Acgaccttgc   Atgggcaggc   Aagttggaag   Aggggttcac   Aatagtctag   7140     Catttgccaa   Aggctggctg   Ctttgtattt   Ctgcacacaa   Gccagtatcc   Tactcttgtt   7200     Tccagcatct   Tgactgagag   Gaaactaaga   Aaggcctgag   Ctgaccttgt   Ccctatcctt   7260     Ggcagggtca   Tgctagatct   Attgcatttt   Gcaggaaaaa   Gctttcctgg   Attgatgccc   7320     Aaggcagggg   Agggtctgtt   Ggagcaaggt   Cagctggctc   Tatcaggccc   Cacctgcagc   7380     Tgctactcac   Caatccggag   Ttcaaaattg   Ttgaatgaat   Gcttgttgat   Ctcctgtatg   7440     Ctttctgtca   Gggcgagtga   Gaagtcagcc   Agagcacaca   Aatgtcccca   Cttgtcttca   7500     Cattgctgaa   Gcaaacatga   Ggagaagaaa   Tcatttaatg   Cggaatgtgg   Gggaacatta   7560     Acatttctgc   Agcaggggct   Ttacgtccta   Acccaaccct   Acctgcacat   Ccctttaagg   7620     Aaataatcat   Gtgggtgagc   Ccctctacac   Tcaagtcact   Ggtatctcag   Aacatgggaa   7680     Gacataagat   Ttgcttgcaa   Gagtgtagta   Tatgtgggtc   Attgtattcc   Ttcttccaca   7740     Tctacacctg   Tctgttcagg   Ttgatgtagc   Atcaattccg   Tagtgtatgt   Tcactggcat   7800     Gtgtgtgaat   Gagtgtatgt   Gtgtatgtgt   Gtgtgtgttg   Ggggtgtgtg   Ggcgtgtggg   7860     Tggccgtgag   Tgtatgtggg   Tatgggtatg   Tgtgtgggta   Tgggtatatg   Tgtgggtatg   7920     Ggtatgtgtg   Tgtatatgtg   Ctcttatgta   Tgtgtagttt   Tccagtctaa   Gaactgtgtc   7980     Tatttccttt   Gaattgctca   8000       <210>   84   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   C20orf85     <400>   84   Gttcaagatg   Cccagatcaa   Tttgaatcga   Gtgatttctc   Agtagaagta   Cagtacaccc   60     Ccatgcaaac   Ttgagtttaa   Ctgggcatcc   Tgtattttta   Tttgctgaat   Cgggccatac   120     Cgctgagtgg   Gagaggcatt   Tcagtggttg   Gaagaggggc   Tcctggtggt   Tctgctaacg   180     Aaggattgat   Aacgcacatc   Ctgattggac   Agagcgagct   Tgtgggtccg   Ttcatagttg   240     Gttgaaacaa   Ggaaggagtc   Tcaggggaga   Cccaggaggt   Gggcgtctca   Gggtgtctaa   300     Gtctgcgtgt   Cagctgtagt   Gacatatggc   Aggttctatg   Tgaccccaac   Agtgctgcca   360     Aaaggggaaa   Ctttgccttt   Tacagacacc   Acctcagaaa   Aagctggacc   Tgcactgctt   420     Cctcaaccct   Cacgtactgc   Tgagattcac   Agccatgctt   Cagccttgaa   Agtcatctcg   480     Gaagataaag   Ccatcttccc   Tggttacgag   Agagaggaag   Actcagaaat   Gtctgctccc   540     Catcttcctc   Aggagttctg   Cccctaggaa   Ggaaggaaga   Agagctgccc   Tccaaggcca   600     Gggttcctca   Ctgagccagt   Tctcccttct   Gcaaaatggt   Cacaaagccc   Tctgcaaggg   660     Gttgctgtga   Ccatctgtat   Gagatcattc   Tcacattgct   Acaaagaaat   Ccctgagact   720     Gggtaattta   Taaagaaaag   Aggtttcatt   Ggctcagttt   Tgcaggctgt   Acaagaagta   780     Taatgctggc   Atctgcttgg   Cttctgggga   Ggcctcagga   Agctgcaatc   Acagcagaag   840     Gcaaagggga   Agtaagtaca   Tcacagacca   Gatcaggagc   Aagggccggg   Ggaggggcca   900     Cacactttta   Aacaaccaga   Tctcgcggga   Actcactcgt   Gatcgcaatg   Acaataccca   960     Ggggaaggtg   Ccaaaccatt   Catgagaaat   Tcacccccat   Gatccaatta   Cctcctatca   1020     Ggccccacct   Ccaacactgg   Ggattagaat   Tcaacataag   Acttgcaggg   Aatacagatc   1080     Cagaccatct   Caccatcaaa   Tcagagcatg   Cagggaagtg   Ccccaggggg   Gctggggaat   1140     Gctggtgccc   Tgagggtgac   Caggacagcc   Tcagactcag   Ggcagagccc   Agaggagcag   1200     Tccctggtga   Gtgcagctct   Gggtcctctc   Tcacctcttg   Agaaagggga   Acccagcctt   1260     Cctgggggac   Agcctccagc   Caccggccat   Ccacaccctc   Tccttcaaca   Ctgtcatcct   1320     Caagaagcaa   Accccacttc   Cacccaaagc   Cacatttcca   Tctccccacg   Ccttccccca   1380     Aatcgtagtg   Tcttagattg   Agggaactgc   Ctgcacgctg   Acaacaaatg   Tgataaacca   1440     Ggagtgaagc   Cctccattgt   Ttgggagccc   Cgctgtcagg   Ctcccgcaga   Gctctctgcc   1500     Tttgctcctc   Tcagcctctg   Cagatcccta   Aaattgggag   Gtgtagtcat   Gatcccctttt   1560     Tccagatgag   Gaaatggggg   Ctcagagttg   Ttaagcaata   Tgcacaaggt   Cactgagatg   1620     Gcacacagca   Aacccgagac   Ctgagctacg   Tcggatccca   Aaacccagac   Atttatccgg   1680     Tactctaccc   Atttctagtc   Ctggacccag   Gctaccccgt   Gcagatattg   Ccaaggagaa   1740     Tggagaagac   Tagcaaactc   Tttatcatcc   Ttgaaaaccc   Aactcactca   Tcacctcctc   1800     Tgtcctcttc   Tgtctcatct   Ggggctggct   Ctgaatcaca   Tataccctat   Gtcatttcgt   1860     Atataaggct   Gcgttatcat   Ttagttgcat   Tcacatctgc   Ttcctgcta   Gattgaactc   1920     Ctgggggacg   Cataggtccct   Gcttctccat   Ttctgcaccc   Atttcatttc   Catggaaccc   1980     Tccagctgca   Ccggccccct   Ttgcattctt   Caaacacccc   Atgctgctcc   Tgcctcggga   2040     Actatactcc   Acaccacccg   Ctctgtggga   Aattcttctg   Atcttccaca   Ccagatctgc   2100     Acccacatgt   Ctcctcctca   Gagagacctg   Ccctgaccgc   Ctgtttaaca   Cagccccaca   2160     Gcccctggcc   Tgtccctgcc   Cccactggcc   Tcatgccctg   Gtgtgactct   Cttcctagca   2220     Cgtcatgcct   Ctctccctgg   Caccaggtca   Cacgtgcatt   Tgtttcctgg   Cttcattatc   2280     Tgtcttccca   Ctcgatgtgc   Cagctccagg   Gaagcagaga   Cctgtcaggt   Ctgactccct   2340     Cctggcacca   Gacacatcaa   Aagctctcaa   Cacacgtcca   Taggatgaag   Gaaccctcga   2400     Tgtctggcac   Tgttaatgaa   Tttagtctta   Atatacatc   Ttaacagaaa   Tgtctcaaaa   2460     Cctcccaagg   Aggaaagcag   Aatttgttct   Tactacataa   Tggatctttc   Ttcctagcca   2520     Tccacttatt   Tcctcccaga   Atatcttccc   Ctctgttgta   Agaatggaga   Cctgtgagaa   2580     Cagtccagga   Agaaaatccc   Agcttcctgc   Ctagagatct   Gtccacccct   Ttgctagccc   2640     Actagcttgc   Agttggctca   Gccgtggacc   Tgggatgtta   Tatattcatt   Aattaatcaa   2700     Ttcagctccg   Atgccagcct   Ctgcttgccc   Actcactaat   Ccagctgagg   Gacagttggg   2760     Accaccctaa   Tactgggcgt   Gggccaggca   Tttccaacag   Ccaagaaaag   Caccatgtgc   2820     Tatgaaggga   Aaacacacta   Gctgagctcc   Cctctaaaca   Ccacacataa   Gtacaaatct   2880     Gttgataagg   Gaagaggcca   Tggagatgga   Ctagggagag   Tctcagatac   Ctaactggtg   2940     Gatacacaca   Ctggcatcct   Cccagaccag   Tgccctggta   Attatctagg   Aggtgacctg   3000     Tagctcaact   Gagtcatgct   Tcctcctctc   Tcagtccccc   Gaggcaggct   Ctggacacct   3060     Gctcatctca   Tggctgctca   Gccagaaaaa   Tgtcctccta   Catcgtgtag   Atgatcccct   3120     Tgctgttgtc   Tcagagccat   Tttccagctc   Tgggtccaca   Acaatggggg   Tatggtagaa   3180     Acctaggggg   Tcaatgaatc   Agtcaaaaaa   Cactggctga   Gcaccccagc   Gatagagtga   3240     Ttactgccta   Taggcaggga   Aaaagagtgt   Ggggtggtgg   Ggtctggagg   Taacattatc   3300     Cgtgaatttc   Atttagggat   Tgttacaaag   Agtggacgcc   Aaccaaaacg   Catattttct   3360     Ccaaagacat   Gtgcagtaat   Attttagcag   Cacttttgtg   Gtggccaaaa   Actcaatgca   3420     Acgcccatca   Gcaaatactg   Ttcaggagca   Gaaatggacg   Ctagggccac   Tcacagcaac   3480     Ggggatgctc   Tctcaatcat   Gacactgggc   Aaaggcagcc   Aggcacaaag   Gagaacatct   3540     Ggatggttcc   Actcacacaa   Agttcaaatc   Acagcaaagc   Taatctttgc   Agagggaagt   3600     Caatgagagc   Cagggaggac   Ggtgaccctg   Ggggccactg   Ggggaggctg   Gcaatgcttt   3660     Gttttctaat   Ctccaggtga   Cggttacagg   Cgagtcctct   Ctttgacata   Ctcaattaag   3720     Ctctgtacac   Ttgagcgtct   Gtccactcgt   Aggtgtgcat   Acttccactg   Cggatttaaa   3780     Ctttcaaaga   Agtctagggt   Gttaggtctg   Gaggtttccc   Caaggtttc   Cacagatgag   3840     Caaatgggcc   Tagaggtgga   Caaagggccc   Agacgtgagc   Aaaggatggc   Agcaagcccg   3900     Gacccaagcg   Acgcggcgaa   Agcacagcga   Ccccaccctc   Gccaggtgca   Gagccatttc   3960     Cgcctccgag   Tcctgcgttg   Cctggcaacc   Ggtctcccag   Gagacgcgag   Acgctgagcc   4020     Cagggccaga   Gcttgcgggg   Cgcacagagc   Ccccaggcct   Catggcgcag   Aaacctctca   4080     Gcaccgcggc   Ggctgaacgc   Atgaaccttg   Tgggtcagga   Tgagatctgg   Taacgcctgg   4140     Gatcgggcaa   Cgcggtgggc   Tcctgttctc   Acctgaagtg   Tccacatctg   Gggtctcagt   4200     Ttccccacca   Agtccgggaa   Gtgatcgacc   Actaaactcg   Aggggcagag   Gggcgtgcgc   4260     Tgaggatggt   Caggggcctt   Gaggaaaggg   Gtcaatgtta   Gggacatgag   Agcgacagga   4320     Gggcctttct   Ccgtctcctt   Ctccctctcc   Tgttgggccc   Accacgaaga   Cgtgggagat   4380     Tggctttcaa   Caatcagcag   Agattggctt   Gttgaaatcc   Aactaacatg   Ttcatgtttt   4440     Ttttttttct   Tcaaatctca   Gcatccaacc   Gaagagtgtt   Catgttttta   Agactgatga   4500     Tttttgtttg   Tttgtttgtt   Tgttttttga   Gatggagtcc   Tgctctatcc   Tccaggctgg   4560     Agtgcagtgg   Cgcgatctcg   Gctcactgca   Acctctgcct   Cctgggttca   Agcaattctc   4620     Tgcctcagct   Tcccgagtag   Ctgggattac   Aggcgcccac   Caccacaccc   Ggctaatgtt   4680     Tttgtatttt   Tagtagagac   Gggctttcac   Catcttggcc   Aggcaggtct   Tgaattcctg   4740     Acgtcgtgat   Ccaccccccct   Cggcctccca   Aagtgttagg   Attgcatgcg   Tgagtcaccg   4800     Cgcctggcca   Aatttttttt   Taaaaaaaga   Aagcaaaaat   Cctaatattt   Gttaaatttg   4860     Aatgaagtac   Atgaaaatcc   Cttgattctc   Ctgggttttt   Aagtaatata   Ttttaacttt   4920     Aaagatacat   Ccattttcta   Aaagatgtat   Gtctagcaga   Catttgtcgt   Ggatatttta   4980     Attggcatgc   Tatctgctac   Gtattattgc   Atctctttga   Aagtttaact   Catatgggaa   5040     Tttacagatt   Tagatataag   Taagttgtag   Taacaataaa   Acatacttgt   Ttccttcta   5100     Aacttcagtt   Atcctattta   Ccctctctat   Aatttttacc   Atttccttgt   Aaaacctcta   5160     Ttagtcactt   Catatgtgtc   Tttaaattgt   Tttcacttga   Tgattttatg   Gaaaacttca   5220     Tatcactctc   Ataaatagaa   Aacctttatc   Atttggcata   Aaatacacaa   Ctatttttta   5280     Ctaaatcttt   Atccaagtgt   Cccaatagga   Gatgctgcca   Cagcaggatc   Tgttccctct   5340     Gtctgaaatg   Cccctktctc   Tcttcttcac   Catacaaact   Tctgctcatc   Cttcaagacc   5400     Caaatctaag   Tgacccctcc   Tctttgaata   Gggcccttgg   Ctacctaaca   Cttaaattgt   5460     Aactggtcca   Aattgggttc   Agccgttaag   Tgtaaactgc   Gtgacaaatt   Acgatgattt   5520     Atttaaaaaa   Aaaaaagatt   Atttaagtga   Ctgtcagccg   Gatgcagtgg   Ctcacacctg   5580     Taatcccagc   Actttgggag   Gccgaggcca   Ggagttgaag   Accagcctgg   Ccaacatggt   5640     Gaaaccccat   Ctctactaaa   Aatacaaaat   Tatccaggca   Tggtggcaca   Cacctgtaat   5700     Cccagctact   Caggaggctg   Aggcaggaga   Attgcttgaa   Cccaggaggc   Ggaggttgca   5760     Gtgaacctag   Attgtgccat   Cgcactccat   Ctagagcaaa   Aaaaaggcga   Aactccatca   5820     Aaaaaaaaaa   Aaaaaaaaaa   Aagactgtca   Cctgtttatt   Cttatgttct   Ttttaatgta   5880     Gttactagaa   Catttcaaat   Tgtgtatgca   Gctcatgttt   Gtggcttatg   Ttacatcttg   5940     Attgaaatag   Actctgcctt   Agatgctcac   Tgcccagggc   Aaagagttga   Ccagggtctc   6000     Cgaaactgtg   Gggtagggat   Atgctgatat   Tgattccaag   Atagaagaaa   Ctagaaaact   6060     Caaaacgatt   Gaatgtttaa   Tttgatgttt   Gcaaaatgtg   Gcacgtgggc   Tcgtctactg   6120     Caatgccact   Cagctcatgg   Gtagttagat   Ataaacaata   Ttagcatgga   Gcaaaagcaa   6180     Ggtcggatta   Gggtggggca   Agtgaggcac   Ttgcgctgca   Atatttagga   Aatgctccac   6240     Gtcaaggtca   Tgcagacgct   Gtctctgcac   Ttgcaggaag   Cagggagtga   Gtgcctcctc   6300     Cacttttgca   Cctcctcaaa   Ttttgagtca   Taagggcctc   Caaaataaga   Gatctggtac   6360     Ctagaaggct   Cctcaggcag   Aatcggcccc   Cagetricggcc   Cttacccggc   Attccctctc   6420     Agccgtaaca   Gccaaccagc   Atctctcttt   Cgttagccac   Gtgtctccct   Tgctggtggg   6480     Aggtgctcag   Catcagaggt   Tctcacgctg   Tctggctcct   Cactccgtcc   Ctggtgcaga   6540     Accactgccc   Agtcaatgtt   Cgtggagaat   Ggaaatgtcc   Cccacagacc   Ccttgaacct   6600     Ttttccgtgt   Tgcccagcac   Tcaggaactt   Tctttttcag   Gaaataccgt   Ctgaaggctg   6660     Aatcggaagc   Acggcagaac   Tggccccaga   Actgggggtt   Tttaacaacc   Ccttttgagg   6720     Aggtaaatat   Aaattgtatg   Agccccaagg   Ttacagaatc   Aatcatttca   Aagaatgaat   6780     Gattacaaag   Tctatcactt   Gcaagaataa   Aactaaagag   Catgttgtag   Gcaaagatca   6840     Ctaactccta   Aaccagaagg   Ttcccgcctt   Tcacagattc   Ctgggcactg   Accacatgcc   6900     Aggcatgttc   Taggtgcttc   Ggcagaacca   Gatgatcaaa   Tctggacaag   Aaccccggtg   6960     Cagagacagg   Tgttgtttta   Tgcccattta   Caaattagga   Aattgagctc   Caagacctgc   7020     Aaagtcacac   Aactgataag   Gaccctactc   Aggtgagaag   Caggtgggtc   Tgatgccaca   7080     Gccacctgac   Ctcagacttc   Ccatctgtaa   Agtgggatga   Gagtcctcac   Ctgcctaact   7140     Gagcgactgt   Gaggtgcaga   Tacaagaagg   Ctataggaac   Ctcacctggc   Ctggaggcca   7200     Agtgacatat   Gagggattct   Tgggaaaatg   Ctgtcggtat   Tccctaaaga   Tgacaagtcc   7260     Agaagtctac   Agggaccagc   Taggtgacag   Aaacaggaga   Cagggccaag   Cataattaat   7320     Cagaaggggt   Ggagactcag   Gcaaagaggc   Cactggtcct   Gtccaaagag   Gcagccagca   7380     Tgagcccagc   Caagtgaaac   Catatgggaa   Agccaactgc   Atattcccat   Cactcaagag   7440     Agtccagaaa   Gccagatgtt   Tacatgaaat   Tttctgagtc   Tagaaatgaa   Atgcttatgt   7500     Gggttctggt   Ggggtggtgg   Ccaccaatct   Gcaacctctc   Aaacttcagg   Acagaacaca   7560     Agagatgcag   Aattaattaa   Aacaccacat   Cagtcaaagt   Atctatgatt   Cacagcagtg   7620     Taaagcccat   Ttgtaattca   Tcccatccta   Cgagctttga   Aattatgctg   Ttcttaatga   7680     Gggtgttttt   Aattcttaga   Gggttccaca   Gtttgaaatt   Tttagcatag   Aatgagttct   7740     Tattaatata   Atatgcataa   Ggagtctata   Ttaatattct   Ttatatgtaa   Ttaaattggg   7800     Ttttcaaaaa   Gcttgatatt   Gcttgaaaaa   Ttaaaaaggg   Gagtggacgc   Tctcctctaa   7860     Tattttaaag   Ttcggtcctg   Aaaacttttt   Ggcatttttt   Gttagtttgt   Ttgttgttgt   7920     Ttgagacagg   Gtctggatct   Gtcacccagg   Ctggagtgca   Gtggcatgat   Ctcagctcac   7980     Tgcagcatcc   Acctccaggc   8000       <210>   85   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   C17orf46     <400>   85   Aatcgctccc   Agtagatata   Tggaaggatg   Agaatgtact   Gcggtctctt   Ctagagagtg   60     Ttagggctgg   Agggaggggt   Ccttgcatgg   Ctggtcttgg   Gattgggacc   Atctgcttca   120     Gcctggtctt   Gggggatgta   Tcagcagagt   Ggccggctca   Atgatctctt   Cagaaccctc   180     Cacctccttg   Accactatgc   Ttccctggct   Tcctcacgtg   Tctctcttct   Ccctctccaa   240     Ctccccctgt   Cccaggtcct   Gctgttcccc   Caggcttctg   Acctcagggc   Ctttgctccc   300     Tttacagaat   Ttccctgggc   Agtttaatca   Acacccacag   Cctcaacccc   Tccataaacg   360     Gcagctgggt   Atggacagga   Gaagaaatta   Ctgttgtgtg   Agcctcttaa   Cagcactggg   420     Ggctgggaga   Aaaagccaga   Cattgactca   Gcttgggacc   Tcgttgcctg   Acttgagaat   480     Gttctattag   Ggattcaagt   Gatattctgc   Agtatatgaa   Ataattgaaa   Taattttttt   540     Tgaggcaggg   Tctcactctg   Tcacccacgc   Tggagtgtag   Tggtgtgatc   Tcggctcact   600     Gtaacctccg   Cctcctgaga   Tcaagcgatt   Ctcctgactc   Agcctcctga   Gcagctggga   660     Ttataggcat   Gcgccacgac   Gcccagctca   Ctttttgtat   Ttttagtaga   Gatggggttt   720     Caccattttg   Gccaggctga   Tctcaaactc   Ctggcctcaa   Atgatctgcc   Tgcctcggcc   780     Tcccaaagtg   Ctgggattac   Aggcatgagc   Caccgtgcct   Ggccgaaata   Atttcaattt   840     Ccagtggttt   Gttgctagta   Tacagaaata   Tatccatctt   Ttgtatcctg   Caactatact   900     Aaaatcttat   Ttgttctcat   Agcttttttt   Ttcttttaga   Ttctatcgga   Ttttctacat   960     Agacaataat   Gtgtgtgagt   Caagacactt   Ttacttcttc   Cctcccaatc   Tggttcctct   1020     Tattttcttt   Acttgcctaa   Ttgcactggg   Gacaatctcc   Atacaatgtt   Gagtaggagt   1080     Gcgtgtgtac   Atcctcgctt   Cgttctgagc   Ttaggggaaa   Gtgtttagcc   Tttcaccatt   1140     Aaggatgatg   Ctagctgtag   Gtttcttcat   Gatgcctttc   Attagcttgg   Gcatctttgt   1200     Gaagtttcgt   Ctcttagatt   Gcttagtttt   Aattaggaat   Ggatgctgga   Ttttgcctaa   1260     Tgctttttct   Gcatttattg   Agatgatcat   Atggtttttc   Tttaatatga   Tattatatat   1320     Gttatacata   Acatacgtta   Taatacatta   Acatatgagt   Aatgttatat   Tatttgagtg   1380     Ataattcttt   Tatattttta   Tattctgttt   Atggtaaaat   Acattgtttt   Ttttgagaca   1440     Gggtctcact   Ctgttgccca   Ggctggagtt   Cagtggcgca   Atttcagcaa   Cctcaacctc   1500     Cctgtctcaa   Gtgatccttc   Cacctcacct   Ctggagtagc   Tgggactaca   Cgtgttcacc   1560     Accaccccca   Gctaattttt   Gttatttttg   Tagagatggg   Tcttgttata   Ttgcccaggc   1620     Tggtcttgaa   Ctcctgggct   Caagctatcc   Acctgccgtg   Gcctcccaaa   Gtgctagatt   1680     Ataggtgtga   Gctaccatgc   Ccagctataa   Atttattttt   Taaaatgtta   Aatcagcctt   1740     Gcgttactgg   Gataaacctc   Atttggttgt   Gatatattac   Cctttttcta   Tgttgttgaa   1800     Tctgattggc   Tttttttcag   Aattttcaca   Tgcatattca   Tgagggatat   Cggtgtataa   1860     Ttttcttttc   Ttgtaatgtc   Tttgttaggt   Tttgataggg   Agtagggtt   Cggcccggga   1920     Ggcagacgtt   Gcagtgagcc   Gagatggtgc   Cattgcactc   Cagcctgggt   Gacagagcaa   1980     Gactctgtct   Caaaaaaaaa   Aaaaaaagga   Gatgaggtct   Cagtatgttg   Cccaggctgg   2040     Tctcaaactc   Ctgagctcaa   Gcgatcttcc   Catcttggcc   Tcccagagtg   Ttgggattac   2100     Aggcgtgagc   Caccatgcct   Ggcctaattt   Cttacctcaa   Attcatatct   Tgtatgtcca   2160     Gactcttaag   Tgtggctgcc   Acggttctgc   Ctgtctgacc   Cctgtctccc   Tttctagtct   2220     Gtcatctctc   Cataccccc   Tctcctcgcc   Ctattcatcc   Ttcatccttt   Cacccaaatg   2280     Agaaacctgg   Gtcatttgtg   Actcctcctc   Cctccgcagc   Tactgccctc   Ctacccctga   2340     Tgctgtcctc   Atctcccagt   Accagagcca   Gcacacaccc   Atgacttcct   Accctttggc   2400     Acttggtgct   Gagtgctttg   Cacattcagt   Cttcatacct   Accctatgcc   Cagttggcca   2460     Cggctctcct   Ctcacagatg   Aggaaacgtg   Tatgaggtca   Tgcagctatt   Aagagcagca   2520     Cacgacccaa   Aggcaggtct   Ggctggctcc   Aaactctggg   Atgctactca   Ctgcactgtc   2580     Ttaaatctct   Ttagtcttcc   Agtgggacca   Ctgcaactat   Gtccccctcc   Aacctggatt   2640     Ttcaatgacc   Tcagagtgag   Cctgctacat   Ctcacttgtc   Tccggttacc   Cccagactcc   2700     Atgtggcctc   Ttggtctgat   Ctctaccttc   Atttttcatc   Tcttggcatc   Cagcttcctg   2760     Tccctcaccc   Taagccgaag   Ctacccccag   Agtaccgcag   Gcctttctgc   Acccagtgcc   2820     Tttgcaaatg   Ctatttctta   Tacctggaaa   Gccttcttct   Ggcaaagtcc   Tactcatgcc   2880     Tgaaagccca   Attcaaataa   Tcagtgtaat   Cctctccatg   Acagacctgg   Ctgtctaatc   2940     Tacgttttac   Cttacaggcg   Tgagccactg   Cacccgacct   Ctggtttttt   Tttttttttt   3000     Tttgacaggg   Tcttgctctg   Tggcccaggc   Tggagtggca   Gcatcatagc   Tcactgcaac   3060     Tcctgggctc   Cagtgagcct   Cccagctcag   Cctcccaagt   Agctgggact   Acaggctcat   3120     Gccgccacac   Ctgtctaatt   Ttaaacattt   Cctgtagagg   Acaaagtctc   Gctatgttgc   3180     Ctaggctgat   Cttgaactcc   Tggcctcatg   Tgatcctccc   Acctctgcct   Cccgaagtgt   3240     Tgggattgca   Ggcgttgagc   Catcatgccc   Acctaatttt   Tgaccgtttt   Taatgctggc   3300     Ccatgccctt   Ctgggagaga   Ggatccccaa   Aagaaagcca   Ccatttcagt   Gggggatctg   3360     Acgcccctat   Gggaagggga   Gacacagggc   Actgggggca   Aacatctttg   Ctcattggtt   3420     Cagagaagag   Tacaaggcat   Caacgaagcg   Ctccgtaaaa   Atgtgctgaa   Gactgccgct   3480     Cctccctgca   Aagcctcaag   Catcaaggag   Ggacaactgg   Atgtgatttt   Ttggatctgc   3540     Agttcaggat   Aattcatgag   Tcgtttcctg   Tgcacaaggc   Cattgctcct   Tctgtggtct   3600     Cagaacccct   Tcaagaacca   Ctgactctgc   Agtccctact   Ccaaggcgcg   Catgcgtgtc   3660     Cgtgagagca   Catgggtgtg   Caccgcgcag   Gggctgaggc   Tgggagccgt   Agtcaggggc   3720     Accgggtggg   Ctttggcggc   Gggtcgacct   Gcctttcagg   Tgccgggggt   Ttgggagcag   3780     Gggaacgggc   Cctgggcgga   Ttcctgaccg   Cccccttcgc   Gcccctcccc   Ctctcacttt   3840     Cgctttcccc   Gcctgcccca   Accctcgccc   Ccgggcgctc   Ggccgctccc   Acctgtcacc   3900     Cccatgcaga   Ccgaggctct   Gtcctggagg   Cggggagcgg   Gctggtggat   Gctgcctctc   3960     Cgcctccagt   Gtgctctttg   Gctgagggac   Tggtgggcgc   Tggaaatatt   Agaggcgccg   4020     Gtgcctgtga   Tgtcgccgcc   Tctgtgacgt   Ccccgccgcg   Accccacagg   Cagggagccg   4080     Catttaggtt   Tcgggcgggc   Ggacggggga   Cggcccgagt   Gaggcgtcct   Ccgaaggctg   4140     Cgggcccgaa   Gccagaactc   Cttcctctcc   Gaagacctcg   Ggggtggggc   Tcgcgcttcc   4200     Gcagcgggcc   Tagagcgaga   Ggcaggcggc   Aggtaagcct   Ggctgtgctg   Gacaggactt   4260     Gcacccgctc   Tgcacgccag   Cggctcaggg   Ctgccgccct   Tttcgtggtc   Ccagggccct   4320     Tccaagaacc   Ggctaaacca   Acccaagccg   Cgcgcacaca   Cacttgtgca   Cacagggagt   4380     Gtggagccag   Attcgataag   Gcaccccgtg   Tgccccagct   Ccatgaccaa   Ggaactcagc   4440     Accccgtgtg   Ccccagctcc   Atgaccaagg   Aactcagcac   Cccgtgtgcc   Ccagctccat   4500     Gaccaaggaa   Ctcagcccac   Aaaggcatcc   Ctggccccat   Gcagggctca   Ggaggcagcg   4560     Gaaagggtta   Agagctcagg   Cctcaaggac   Aggaggggag   Ggtggagggc   Ctgtggtgtg   4620     Catccggcat   Ccctggatgg   Tcagggccca   Gaacccatcc   Ctattccct   Tctggtggta   4680     Gggggctgcc   Taacttgggc   Agtggcacaa   Agcatgcagg   Ctttgttgtc   Ctcctcctcc   4740     Acccctcagc   Ctggcatatt   Ttggcgaggg   Acttccctga   Tgccaccggg   Caaggtatct   4800     Tgcctaactg   Gtctgaatga   Ctagcccagc   Gttgggacta   Gaagcagcca   Ctgggaggag   4860     Tggtgggaaa   Gcagccccac   Tcaagggctg   Aaacagtcct   Tgtccaaaac   Aaggggact   4920     Tgaaaagatc   Tcagcaagaa   Ggcaaagaga   Ggcagctgtt   Agggtcgtga   Ggttcagcag   4980     Gccggcaggc   Aagagagagg   Acaccgatgg   Cctggaaaca   Tttgtcatca   Ccccaaactt   5040     Tattgcttac   Aaagagttct   Ctacaaccca   Gactctgcag   Taccaaggct   Gcagttcttt   5100     Atgtgctggg   Ggccggggct   Ctctccccgg   Gagcagtctg   Actcaatgtg   Gacagctgga   5160     Caaaggctgt   Cttggcaaga   Tgtgggaatg   Agcttctccc   Acggagtctc   Ggcgtcccct   5220     Gccccaggag   Gttgaggcta   Gcagacaccc   Cctgacgatt   Cacagctgat   Tatagtcctac   5280     Gtgagtcctg   Agtagctccc   Ctgggagaag   Aggctaagct   Ggggcaatgg   Ggaagggggt   5340     Gctattctta   Gagaaatctg   Gaagaggttt   Gaggagtcac   Atgcatgtgg   Acagctcaag   5400     Actgtgtccc   Ttcaccccat   Ctcctggctt   Gctatgctcc   Tacagtgtca   Ctgccctgcc   5460     Ctgccctgcc   Agagggcagc   Catgaaagtg   Ctttgaggtc   Atcagagtgc   Aaagtgccgt   5520     Cggcagtacc   Ctctggccag   Gggcagggca   Gggtgagtgt   Cagtgtgatg   Ctgagctgtg   5580     Ctctggggaa   Ccagcacgct   Ggacactgat   Agtggggctg   Gggcgccgga   Gcgtctctct   5640     Ctgctgcttt   Ccttagcact   Gatcatgtcc   Atccacagac   Tgttcctgtc   Aggcatatcc   5700     Tgcatcaccc   Ttcaccttta   Cagatgaggg   Aactgagtgc   Cagcgagtct   Ggggcagtgc   5760     Tgggcctgaa   Ggggctcggg   Gcctgctgct   Ctggggaaga   Gtggtagcca   Gcagcaaagg   5820     Ggcacatgtc   Tggggactga   Gaaccacttc   Acttacacac   Cttctttggt   Cctgtgctga   5880     Accagaggtc   Aactcaggac   Ctgtgttgca   Acaacctgaa   Aagtgtggtg   Tattctacca   5940     Gggagccttc   Ccagggtcag   Gcattctttt   Cccctacacc   Caaaaggggt   Gagctggcca   6000     Ggtgaggcca   Ggcaaggggt   Ttagagggcc   Cccttaacct   Acgggcgggc   Atacctgctg   6060     Acctggttct   Gcactgaacc   Tgagtttggg   Cccttacaca   Cttgacactc   Tcacagcagc   6120     Ctggagggtg   Aggggccgag   Gggctcgccc   Accccttctg   Acccaggctg   Gaagctgctc   6180     Tcccctgtct   Gccagcaaat   Ggtcactgat   Ccaagcgggt   Caggccaact   Cgactggagc   6240     Agggcagaga   Agatcctgtt   Tgtttcccga   Ggtaactcct   Gccatcctcc   Tctgtctctt   6300     Cacgtggcgg   Agtgttttct   Cagcagggtg   Gggcagggct   Caggtgtgaa   Atcctgggag   6360     Gcattctgct   Tgcccccacc   Ttgctgctgc   Gaggccctgg   Tcccactgct   Gagccggggg   6420     Ctggcagatc   Cctgggaacg   Gctgagcctg   Tgtttcaggg   Cagcatcgtg   Caccgagcag   6480     Gaaggctgct   Tccggcagtg   Tggagccggc   Ggtggagggc   Agggttaggg   Cctgttctcc   6540     Agctggccat   Gcttgaccct   Ccagctccag   Gcgaagctgc   Catcaggggc   Cagtgtgcac   6600     Tgcaggtcga   Tgcccgagtc   Tggcacctcc   Atgtcgtagc   Gaacaggctg   Cccgtctttg   6660     Gtgaccaagc   Tgaaggctgc   Agctgggatc   Taagggtgga   Gcaaaccagt   Gggctgagat   6720     Catggcatag   Ggctcaagcc   Atgtagaaag   Gtaaagacat   Ctccttccag   Ccagaccggc   6780     Agccctaagg   Gcactgcctg   Tctgtcattc   Cacgggactc   Agagaatccc   Acccggctca   6840     Agtgtaggtc   Tggaggacct   Ctttgtcacc   Actgccagcc   Ttgctttgag   Gccctgggaa   6900     Atgctttgag   Gtcctggggg   Acgttgaagg   Ccaattccaa   Gttatcccta   Gagtgccatt   6960     Ctacttcttt   Gaaagctttc   Ctcctggagg   Gtggggccag   Ctgcattggc   Ttctgggact   7020     Ctgcccgtca   Gagtgtacct   Gcccccctta   Cctggctgct   Gatgccagtg   Gcgatgtctc   7080     Ccactttgac   Ccggtggaac   Tcccggatgt   Gcaggtgttc   Accattaaga   Gactgtattt   7140     Ggactttcac   Acctagaagg   Cggacaaggt   Gatagtcagg   Agagcggctg   Ctggctcccc   7200     Aaggaccagg   Gtcctggcag   Gggctggggg   Aacgtttttg   Ttaaaagtca   Ctctgcccta   7260     Tgtaggggga   Gcaggtctgg   Ctgtgatgga   Gcagcagaga   Taaaatttag   Gctggtctaa   7320     Gcacagctgc   Atttttttgt   Ttttgagaca   Gagtctcact   Gtgtcgccct   Ggctggagtg   7380     Cagtggcgtg   Atctcagttc   Actgcaacct   Ttccctcccg   Ggttcaagtg   Attctcctgc   7440     Ctcagcctct   Caagtagctg   Ggattacagg   Catgcgccac   Tatacccagc   Taatttttgt   7500     Atttttagta   Gagacggggt   Ttcaccatgt   Tggccaggct   Ggtctcgaac   Ccctgacctc   7560     Atgtaatcca   Cctgccttgg   Cctcccaaag   Tgctgggatt   Acaggtgtgg   Gccaccacac   7620     Ctggtcacaa   Agctgcattt   Ttataagaaa   Aaaaaaattc   Aggctggaac   Agccctcata   7680     Ttatatacac   Ctgctagttc   Ttcctggccg   Tcagcacctg   Ggatttggcc   Tgtgcattgc   7740     Taagagctgg   Ggctggctcc   Tatggggaag   Ttagatttca   Acttggatgc   Aaagcagaaa   7800     Ggaactgaac   Acaaggattc   Ttaattaga   Tttagggcaa   Tttagattgt   Tgcctgagtt   7860     Gaagtggcct   Ttggccagcc   Atggggccct   Gatgccatga   Gtcacacttg   Ccctggagag   7920     Ggccagggaa   Ctccaagctg   Atgatgccct   Tgttgtagca   Aagccacatc   Ataacctatg   7980     Caatcaagct   Tgaaaacgaa   8000       <210>   86   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   FOXI2     <400>   86   Gaatcattgg   Ttaacgcagg   Agttctccat   Gggagtgatt   Tggctccaca   Gaggacagtt   60     Ggccatgtct   Gaagacattt   Ttggttgcca   Taatagtgga   Ggcgttgtcc   Acattgagca   120     Ggtagaaagc   Aggagtactg   Ctaaaaatcc   Cacaacacac   Aggacaacaa   Aggtttacct   180     Agccccaaat   Gtcaatagtg   Ctgaggttga   Caaaccctga   Accagaggcc   Gagaattaaa   240     Gccacaggag   Tgaagaagag   Gaccgagaat   Ggagccctgc   Agaaccccag   Cctcagagca   300     Aggcaagcca   Gcccagagcc   Cgagaagaag   Cgagagaagg   Ggaggtcaac   Cagatgaaca   360     Gtgttgaaaa   Gcaggcagag   Aaagaggtgt   Tgattctggc   Gggtgtcaag   Ggctgctgcg   420     Agtcaagcaa   Aatgaggagt   Aaaaaccatc   Attggattta   Gggtgaccaa   Ggccaccaga   480     Ggctgtgcct   Gagcagtttc   Agttgagtcg   Tgggggtgga   Cggctgtctg   Tgctgagtga   540     Agaggtgct   Cttgagagag   Gaggttgggg   Caacagccac   Cagagaccag   Gcttctgaag   600     Acctggagac   Acctcaaaag   Ggatgtgggc   Tgaagggatt   Tgttgccacg   Gagagaattg   660     Agatctgcaa   Atgctgatgg   Gaagaagaga   Gaggaggaga   Tcacagagtg   Aggcccctga   720     Gaaaagtgtg   Agaagagaac   Taagggcaca   Acgtctcttc   Caggcccaag   Cagtgagtgt   780     Cccttaaggtg   Ctgcatccca   Ggtgtgcacc   Tgagtcccag   Tcctgcccag   Gagagactgg   840     Cctgatgatg   Gagaaggaga   Agaggtgccc   Ccagcaacag   Gtgtaggtgc   Agctggaggt   900     Gggcttggca   Atttgaaagg   Tgggaggttg   Gggagactta   Tcctccatgt   Aggcagcggg   960     Ggtcactttt   Gagaataaag   Gagaagaaaa   Tggatcagag   Gcctgagagg   Ggtgtggagg   1020     Gctgctctgt   Ttagagaacc   Ccagcaggac   Tcccagacag   Ggcacagtct   Ttgtccttgt   1080     Gatttctctc   Ccgatatttt   Ttttttctct   Tagaaaaatt   Ctcatcaaag   Ttccatgcaa   1140     Gaccatttaa   Gggttaacac   Attttccccc   Aaaatgactg   Cagtccctct   Actgaaattc   1200     Attttatgag   Tccagtctgt   Tgaaagataa   Gaaaactatc   Acagtggaga   Tggaagatgg   1260     Aaattgggct   Cagagagcaa   Gaagagggtga   Aaaagatatg   Gacacatata   Tccatggcac   1320     Aaattttaat   Gatttctgta   Aagtataatt   Aaaggaaatt   Acaggaagtt   Tcatttgatt   1380     Ttcttagagg   Tcctgaaact   Cacgagtgtt   Acagagttat   Agtatttaca   Gaaagaaagg   1440     Ctattaaaat   Tcaagagaat   Gtggaaggag   Ctgccgtctt   Ttttgaaaaa   Attcctttac   1500     Attgcaaaag   Atgacccaag   Ctattcttta   Aaattcaaca   Tctctgatat   Tattctcaca   1560     Gtagagcagt   Taactgcaga   Taaaattagt   Tcttcctgtc   Aaatcattgt   Gttattccac   1620     Caaaataggt   Gtcttctacg   Tacacagcct   Tggacaatgg   Aaatccttga   Caaggagcag   1680     Ctgcttttgt   Ccagtacttc   Acgtcagccg   Ctagaaagca   Gggacggcca   Ggcgggctct   1740     Tgcagaacct   Gccatgccgg   Tggccctgcg   Ggtccggctg   Cagctcccac   Cttcgcactc   1800     Tctctgggat   Gatttgggtc   Aaggcagagc   Tgtgcagcct   Ctgtacatcc   Tcatcaagca   1860     Cggactcaaa   Aactgagtcc   Taatcagcag   Ccgtttcaaa   Attcctgaag   Gtgtggagtc   1920     Atcccagacc   Ctctggcaag   Ctccggaagg   Gtgttatggg   Aggaaagtgg   Gtgtctatag   1980     Gcggtgatat   Gggtttgcac   Cataaggaga   Ggatccaagt   Cctgtttgct   Acacatgtgc   2040     Tgagggaaag   Acactttctt   Caagaggtag   Tcaccaaaaa   Gctggtcaca   Cctacggaca   2100     Gcagcatggt   Ttccccgag   Gggggcactg   Gaaatcgcta   Agctgagtgg   Caggtggcac   2160     Tggctgctct   Tttgggtgga   Agcaatagac   Tgtgttcacc   Tgagactcag   Caagaagagg   2220     Cgtgtcccac   Cccgagtact   Tcccgttgac   Cccgcaaccg   Cccctgcaac   Gaggggtagg   2280     Gaaggggagg   Gcggcttcgt   Aaaaggcacc   Tgggaccccc   Acaactagca   Ttcctttgac   2340     Aaaaatcaga   Aatctttggg   Aaagggggaa   Ggaaaagggg   Gcagagtcca   Gccgaaaagc   2400     Cgacctcaaa   Gaaccatttt   Ggggtatttc   Ttttctcttg   Actgcttggg   Aaatgccttc   2460     Ggttcaccca   Ccacttctga   Aggggcttca   Cttctaaggc   Gagaggccaa   Cgtcccaaca   2520     Gagggactct   Cacttctttc   Tgccatttgt   Taaattgttc   Cataattag   Ttgttttaca   2580     Taaaatttgg   Aactacgatc   Tgggaggccg   Aggggctgca   Ccaccagtaa   Gtcgctgact   2640     Caaatgggcc   Ctttaatccc   Caaacccaaa   Ctctttcctc   Gatcgaaccg   Ctggcctcaa   2700     Cctacaagcc   Tcctccaccg   Ccaaaagtcg   Ggaagggttg   Gtccttttgt   Tttacaaatg   2760     Aattaaaatt   Agatccacag   Gcccgcgtaa   Cgctggggaa   Tacccagggc   Gaggccagct   2820     Tccaggaggt   Cagcgccaac   Accgccggca   Ggaatctggg   Gggatgggga   Ggtctcctca   2880     Tctctgagcc   Ttgagcacca   Ggcctgaatt   Ttcgcctctt   Tcgcacaggt   Gcccgactcg   2940     Gagtccggga   Ggcgggccct   Ctttccaggt   Acccagccca   Gcgtcagcct   Gggtccatcc   3000     Tccgccaccc   Cacagcgcgg   Ggagcagggg   Aggccgaaag   Ccgggcagct   Tggggggccg   3060     Ggataacccg   Ggctgcagca   Accccgggcg   Gcagcaggac   Tggagagctg   Gtgtcggacg   3120     Cactgcagag   Acgtccctgt   Tttcggcgcg   Tcctccgaca   Cccagcagag   Agcttggcgc   3180     Tctccgctct   Gcgcgcccga   Ggtcacagcg   Cggagaaacc   Tggcggggcc   Ccggactccc   3240     Cggcttggga   Aaagcgatga   Ctgccctgaa   Ctgctggggc   Gttcgaaatt   Tccagggtcc   3300     Cgaccctccg   Tggggtacgc   Gcgacttcgg   Cgcagatgtc   Agtccgctgc   Cttccgggtt   3360     Gagggagcga   Ggactccaga   Cgaccccagg   Gccgctgtcc   Aggcccagcc   Ccgcgttctc   3420     Cacctcgcca   Cctcgctctg   Cggctccagc   Ctggagatct   Acggacttca   Ttgcgatctc   3480     Ttgcgcagtg   Tagtcgccct   Ctatccctag   Ccccgagtcc   Cgggtaaccc   Aggggccccg   3540     Gcgaggcgag   Tttctttggg   Gcgagatgtc   Ccgagccgag   Caaaggggcc   Gcgcattgga   3600     Cggggctccc   Aagccacagc   Cctgggggcc   Ttgaggagtc   Gtggtacggt   Ccagggcagt   3660     Cggggctgcg   Gggcccgtga   Agccagacga   Ggctacggac   Ttagggtccc   Tgcaaccaag   3720     Accgcgagcg   Actgtggact   Cgggacggat   Cgcacaaagg   Aggaaggggg   Aatcagaggg   3780     Gcgtccggtc   Caggacgtgt   Caggcctggg   Cggggcggaa   Aactgacacc   Agggcgagga   3840     Caaggatttc   Gctcctccag   Ggctgccagg   Ggaggggctc   Gccaccgtca   Ctctccatgg   3900     Gctctggccc   Cgacggtgtt   Taaagggcgg   Agggctgggc   Cgggctggtc   Gcacccgggc   3960     Gctgctggcg   Gccaagctgg   Atgggtcgcc   Agtgagtttc   Ggtgcggcac   Cgctggccca   4020     Ggcccgggcg   Cggctggaca   Tggccaccta   Ctgcgacgac   Ctgggcccct   Cctcggcccc   4080     Gcccggccag   Gcccaggcca   Ccgcgcaccc   Cccgggctat   Gagccagggg   Atctgggcgc   4140     Ggtgggcggg   Ggccccctcc   Tgtgggtgaa   Cgcgccagcg   Ctcagcccca   Agtcctacgc   4200     Ttcgggtccc   Gggcctgcgc   Cgccctacgc   Ggccccgagc   Tacggggctc   Ccggcccgct   4260     Cctcggcgcc   Ccgggcggcc   Tggcgggcgc   Cgacctcgcc   Tggctgagcc   Tctccggcca   4320     Gcaggagctg   Ctgaggctgg   Tgcggccgcc   Ctactcctac   Tcggcgctca   Tcgccatggc   4380     Catccagagc   Gcgccgctgc   Ggaagctgac   Gctcagccag   Atctaccagt   Acgtggctgg   4440     Taactcccct   Ttctacaagc   Gcagcaaggc   Gggctggcag   Aactccatcc   Gccacaacct   4500     Gtcgctcaac   Gactgcttca   Gaagagtgcc   Ccgcgacgag   Gacgacccag   Gtaacagcgg   4560     Cgcgccggct   Cgctccgtcc   Aggactcccc   Atcttcccgc   Cgggccgcgg   Gcactccggg   4620     Ggtgggagca   Ccttagacaa   Cctaatttct   Ccctgcgcgg   Ttggggatac   Ccggggagga   4680     Gggagaaggg   Gaagaagtgc   Ttgggcatgg   Acaggttctc   Agacagcggc   Tgagcccacc   4740     Acaggcccgc   Gtttacagtg   Cggcggtccc   Ggggctctca   Atctctgtgc   Gctccttcgg   4800     Aggaagaagc   Gggagagcca   Gcaagctggg   Tgaccttggg   Agtgactcaa   Cttccctggg   4860     Cctcagtgcc   Ctacctggta   Aaatggggaa   Gacagcgcct   Accccaagga   Tgggcaaaac   4920     Aaataggatg   Cccgtttgga   Aagctctgga   Gcctacctgg   Gggcctggcg   Tggtctgcgc   4980     Tgtccttggc   Agagcggctg   Gcggagtccc   Accattagca   Tctcgcaggc   Cttccttcac   5040     Cttaacgggg   Ctcggccttt   Cccagggctc   Ccttcctcct   Cctttctgga   Ttgtcacttt   5100     Cttcccagtc   Ctgctgtgga   Ggcccatcgg   Gtacagagtg   Cccgtcaagg   Gtggaatggg   5160     Ggcgaggact   Cagaccctct   Gtaagggcca   Gcaggggatc   Tttctgaagc   Tgacctcctc   5220     Gctggctcac   Accacggccc   Gtcaaagctc   Gaaccttctg   Aactgggctg   Tttcttcttc   5280     Tgcaggtaaa   Ggcaattact   Ggaccctgga   Ccccaactgc   Gagaagatgt   Ttgacaacgg   5340     Gaacttccga   Aggaagagga   Aggagagagc   Tgaagccagc   Gcggccgtgc   Gctcgggagc   5400     Caggagcgtg   Ggaggggccg   Aggcgccagc   Gctggagccc   Ccgagcgcgg   Cttgcctgga   5460     Cctgcaggcc   Tcgccctctc   Catccgcacc   Cgaggccgcc   Acctgcttct   Ccggtttcgc   5520     Ttctgctatg   Agcgctctgg   Ctggcggcct   Tggcaccttc   Cccgggggcc   Tggcgggcga   5580     Cttttctttc   Gggaggcggc   Caccgacagt   Cgccacccac   Gctccccaga   Cccttaaccc   5640     Ctccccggc   Ttcgcccctg   Gccaccagac   Cgcggccgcc   Ggcttccgcc   Tcagtcacct   5700     Cctctacagc   Cgggaaggga   Ccgaagtttg   Aagggaggct   Ggaggctagc   Cgggtgcggg   5760     Tccagaggtg   Ctgagctcag   Gcctccggtt   Tcccctggtg   Acagccccac   Gtgttggcgt   5820     Tgaaggcctt   Ggtgccctgg   Gaggaagcgc   Agagccgggg   Gcggctcggc   Cagcagggag   5880     Ctgggctgag   Cggctcttgg   Gctttggggt   Gggtggccct   Tctgctgtgc   Acccctcacc   5940     Caggcgacct   Tcggaacctc   Cctgctctgc   Ctctaagtcc   Agccgccctg   Ggcgtctaga   6000     Acctgtgctc   Tcgagggatt   Tgccttgaag   Gggcggcggg   Tcggccctca   Gctccagcgt   6060     Tttccaagga   Ggctggctga   Ctccaaagag   Ccttagagca   Gatgggaaga   Aggtgggctg   6120     Cgagagcggc   Ccaggtggtg   Ggggcccttt   Ccaccctccac   Ccagcttggc   Ccacctggct   6180     Cagggccttc   Ccttctgctt   Cagggaagct   Gccgcagggg   Ctgggggaca   Gagctcagga   6240     Gcagctgcag   Tgggctccag   Gtgggccagg   Agcctgcagt   Gaggggatct   Gagacagttg   6300     Gcattgggtc   Ctgtgtaagg   Aaggtctgc   Taatggttgg   Aactgctggt   Ggtgggaggg   6360     Agaagcactg   Cgtgggcaga   Aagcgccctt   Gggataccag   Ctcccttccc   Tgtcactcag   6420     Ccctggtcct   Tgatgacccc   Cctctaggac   Aaggcaactc   Cccagggccc   Cgccaccact   6480     Gaccacagga   Gcggtgccca   Gcacccagga   Gttccccaag   Ggtccaggtt   Tgtgccaccc   6540     Acacccacac   Tcacacccac   Actcacaccc   Acactcacac   Ccacaccccac   Acccacaccc   6600     Acactcacac   Tcacactcac   Acccacactc   Acacccacac   Tcacacccac   Acccacaccc   6660     Acactcacac   Acactcacac   Ccacaccccac   Actcacaccc   Acacacactc   Acacccacac   6720     Acacccacac   Tcatactcac   Actcacaccc   Acactcacac   Cacacccaca   Ctcacactga   6780     Cacccacact   Cacacccaca   Ctcacactga   Cacccacact   Cacacccaca   Ctcatactca   6840     Cactcacacc   Cacactcaca   Ctcacaccca   Cactcacacc   Acactcacac   Ccacacacac   6900     Ccacactcat   Actcacaccc   Acacccacac   Tcatactcac   Acacccacac   Ccacaccccac   6960     Acccacaccc   Acacccacac   Ccacactcac   Acaggctcat   Ggaaggccac   Acttgttttg   7020     Gtctctttcc   Cctccaaacc   Cacagtttga   Gccaaagctg   Tgcgtgtgtt   Cagagctcct   7080     Gaacagcagc   Ctcctgtgta   Aattgaaccc   Tgccccaccc   Agttccttct   Tagggatggt   7140     Atctttgtga   Aggacaagga   Gcccccagtc   Actgggaaga   Ggaatttttt   Ggcctctgta   7200     Ctccttagag   Gacctaagtg   Ccccagtcag   Atgccctgag   Tctttgtggc   Atctgggact   7260     Ccctggagat   Ggagacgttg   Gtgggggggg   Ggtacccacc   Ttgttgttga   Tgggggtacc   7320     Tatcttccct   Gcattttggg   Ggagggtggg   Aggggtcctt   Cccaggaaga   Gagtggagac   7380     Aggttactgt   Tactttggag   Tgggacaggc   Tggtttagca   Atcctaagcc   Ccaggccacg   7440     Aggtattcct   Gatctgcctg   Cagggcccct   Cactgcagct   Gccaccagtg   Ctggaaatga   7500     Gagcagggct   Cctgactgtc   Ctagagctg   Actcatcatg   Gccctgctga   Agaggtaggt   7560     Ggtgtgtgt   Gtgtgcgtgt   Gtgcgtaaga   Cagagaggga   Gggagaagga   Aggaggcggg   7620     Ggaacatgga   Gagaaggagc   Caggagttgg   Gataaacctg   Gccctggtca   Tatgtttcat   7680     Cagcagtggc   Tcctaactcc   Acgtgccatc   Tctgctgctg   Ccctccacaa   Gcaggtgagc   7740     Agaggccag   Ttgtgttgaa   Ggtgatgatg   Tcgcctaact   Aaactcacaa   Ccaacccgca   7800     Atctctcttg   Gggggacact   Ccccataagc   Aatacaatta   Aagaagacca   Ggaaaggaaa   7860     Ataaattcct   Tagcttatac   Atttaaaaag   Tatcccttga   Acctatttta   Atagaatgaa   7920     Atgctaaaaa   Taaagaccaa   Tataacatac   Atagctggca   Tgtgtatgct   Atttcgtata   7980     Gaaattccac   Tgctatgaca   8000       <210>   87   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H4I     <400>   87   Aggttaagtt   Tttaaaaata   Gatattttac   Tacccaaact   Cacagacttc   Cccttcaaca   60     Ccctccaatt   Gctgaatttt   Ttccttaggg   Gcattgtgac   Atataagtac   Ggacctcagg   120     Ttaaaaactc   Ttgctctaaa   Atttggtcaa   Cctaccccat   Ttcttttcag   Ctccttttct   180     Ctagatacct   Cctcttccta   Tctggaattt   Ctttagcact   Ttagctactg   Acatctcata   240     Accttttact   Gtgtctgttt   Cttgttctta   Aaatataact   Acttccaatc   Ctagtataaa   300     Tacgatgttt   Tggaacagaa   Acaagtgctg   Acaatatcta   Gcaaaaatag   Gtacttgaga   360     Ggccccccaa   Atagtaaaat   Atttggcttt   Ttgatggatt   Tttatactgt   Gtaacccaat   420     Aattttactc   Atttttgaat   Tgccctgtct   Ttaaaggtct   Ttcaacttat   Ttaaattaat   480     Atttaataaa   Tttcacaatt   Aaatatacag   Tggttggaca   Caggatgtac   Tttgcaagtg   540     Taactgttac   Tggaaagggg   Tcccaatcca   Gaccccaaga   Gagagttctt   Gggtctttct   600     Caagaaagaa   Ttcaaggcaa   Atccatagag   Tacagtgaaa   Gcaagtttat   Tagagaagta   660     Aagaaaattg   Ttcttttgtt   Ctattctaag   Gatatttata   Gttatttctt   Gactacatgc   720     Taaacaaggg   Gtggattctt   Catgagtttt   Ctgggaacgg   Ggtgggcaat   Tccccaactg   780     Agaggtcctc   Ccccttttag   Accctatagg   Gtaactttcc   Gacgttgcca   Tggcatctgt   840     Aaatggtcat   Ggcactggta   Ggagtgtctt   Ttagcatgct   Aatgcattat   Aagtagtgta   900     Taatgagcag   Tgaggataac   Cagaggtcaa   Tttcctcacc   Atcttgattt   Tggtaggttt   960     Tggctggctt   Ctttaccgca   Tgcttttatt   Agcaaggtct   Ttgtgacctg   Tactttgtgc   1020     Tgacctattc   Tgtgactaca   Aatgccttaa   Gcctctggga   Atgcagccca   Gtaggcctca   1080     Gccttatttt   Acccagcccc   Tattcaagat   Ggagtttctc   Tggtttaaac   Gcctctgaca   1140     Aagtttgctg   Ccagatttgt   Tttgtaatgt   Gaaagaatgt   Gagaactcag   Agttactcta   1200     Tttgaactaa   Gtttatcttg   Atagtcagtt   Atcctgttag   Aaaacagact   Gattagcata   1260     Acattttttt   Aaaatgttat   Actgcgtgta   Tgtttactat   Ttcagaacta   Aatttaccgt   1320     Caatttcaga   Aactaaagag   Tctgacaaac   Tcaaatatcc   Ttgtagggga   Ggcaaaattt   1380     Tacctctgtc   Ctcttaagag   Tttttatggc   Tggcctgata   Attaactga   Cataagatta   1440     Agaggagaaa   Accatataaa   Tttaatataa   Attttatgtg   Gcatgggaca   Tgggagctct   1500     Aataatagac   Cccaaagaag   Tagcaaaacc   Taaatgcttt   Tatagtaggt   Tgaatggagt   1560     Aaattgtgga   Aatgtaacta   Tgtaggaagg   Ctaaaggaaa   Acaagaatta   Ttttaagatc   1620     Tgcttggaca   Gaattctctt   Ggtttcaact   Tcctgtcctt   Gatgaaaatg   Ttcttttcct   1680     Tttggtacag   Ggaggacatc   Ttccacaggg   Gaattttaat   Tcctgctttt   Aagggggtaa   1740     Aagggaacgg   Tcaaagtgcc   Tttcttgtac   Ctactctttt   Taaaattgcc   Tgtatctcag   1800     Aataattctt   Attccaaaat   Ggcatatttt   Gggatggcat   Gctctgccac   Cttttaccat   1860     Tcattgctat   Ccttgtcact   Aattgctatg   Cgaaaactca   Tgaaatcaga   Tacagaaaaa   1920     Ggcttctgat   Tagtgagaag   Ctcaagtaga   Gaaatatact   Tgttaactaa   Tgttggggaa   1980     Atacaatttt   Aaaatcttct   Cccaaagaag   Acaaaggaaa   Taattttatt   Attgaataag   2040     Cattaaacca   Gggagagttg   Cttatcacag   Gaaaccttat   Gaagaggttg   Caaaagcaga   2100     Aagaaatctt   Gcttattatg   Tatggctaca   Ttggataggt   Tttgcaattc   Gaagtcaggt   2160     Gacagctaaa   Gttcagccca   Ttttctcgct   Ggaaactggg   Agacagacca   Ctatcttttt   2220     Taatgattaa   Catttcaaag   Ggatagggct   Ccaggcattg   Agaaaatatt   Ctgagttata   2280     Aggcctattt   Agccattaaa   Aggatttaca   Tacattttaa   Aaggacagag   Aaagacattt   2340     Tgaaagtgat   Gggaaaggaa   Agggaagtct   Tttgttttca   Acagataatt   Aagcctctca   2400     Tttttaattt   Gttattaccc   Ttagattaac   Gtattcaatt   Aacctatgct   Accttaccct   2460     Ctttacaaca   Tatactgaat   Tcagctacag   Caagttacag   Ccagtcatat   Caattttttt   2520     Ttgttttcca   Aaggtgtat   Gcaagttttc   Ttttattgca   Acataaatgc   Aaaaatttct   2580     Aaagtatttt   Aatgaaaagt   Tttacttcat   Ttactttatg   Acatttaagt   Ggaatacttt   2640     Gaaaatactt   Caagcactgc   Tgtaaggtac   Tcattaaaat   Aaagagtagc   Aagaaaatca   2700     Ccaaatgggc   Cgggtgcggt   Ggctcatata   Ttcagtatat   Gataataagt   Tcctcaaatc   2760     Aggtgggaga   Atagttaatg   Tattgtgctg   Actaaccaac   Tgattaactt   Tttgaaaagt   2820     Tatttctata   Tacaagaaat   Caagtcctta   Ttagtaaagt   Tagattactt   Taaatggttc   2880     Tacccagcat   Tagttaaggt   Tgtaggcata   Tcaggaactg   Ctactggtgc   Aggggccaag   2940     Agaaaacctc   Cctttgggcc   Tctgaaagtt   Cactgaaaat   Caactgacaa   Gattaataag   3000     Agaaaaggca   Tacaaattta   Ttaaggtaca   Gggctgagga   Ccacagaata   Ttcccccaac   3060     Cccccaggtg   Ggtacagaag   Cttatatact   Ctttctcaga   Ggcaaaagag   Gagatgggta   3120     Atgtagacaa   Ttctttgagg   Aacagtaaat   Gattattaga   Gagaaggaat   Ggaccaagga   3180     Gacagaaatt   Aacttgtaaa   Tgattctctt   Tggaatctga   Atgagatcaa   Gaggccagct   3240     Ttagcttgtg   Gaaaagtcca   Tctaggtatg   Gttgcattct   Cgtcttcttt   Tctgcagtag   3300     Ataatgaggt   Aaccgaaggc   Aattgtgctt   Cttttgataa   Gaagctttct   Tggtcatatc   3360     Aggaaattcc   Agagaaagtc   Cctccctgta   Tttggggaag   Agaaacagga   Caaagttaga   3420     Gggaccttga   Ttcttagact   Tgtttctgag   Aaccctcaat   Tttcaaaaac   Acccaccatt   3480     Accaagctcg   Atatttgggg   Ggataattct   Ccacccccaaa   Cactagaaat   Gaaaataagt   3540     Agaaaagaac   Ttagcaatat   Acctgaacga   Tctttaaatt   Ctatgagtct   Atcttgttct   3600     Attgctagga   Atttagcata   Tggagtatat   Ttccattgta   Tattaaggag   Aaaaatgcca   3660     Caaaatagca   Tagttccata   Caaataatgt   Taaaggaaaa   Catgcatata   Tgcagagata   3720     Acattctttt   Tgctttatgt   Atcttctata   Atgttaacat   Ttttgttatg   Aggcaggaat   3780     Catgttaaat   Gaaaaaagga   Aaaacagcct   Aggtcttgag   Gattaaaaag   Gactgaagga   3840     Gaacaagagg   Gagtagagca   Cagcaggcct   Gtttcccttt   Taggtcccct   Ccccacatagc   3900     Agagggactt   Cccgccaaag   Ctcttccggt   Tttcagtctg   Gtccgcagag   Gttacccata   3960     Aaagaaagct   Gccatcacag   Gcagcagacc   Tttgttctct   Gaccacttga   Taatgtcagg   4020     Acgcggcaaa   Ggaggtaagg   Gcctggggaa   Agggggtgcc   Aagcgccacc   Gcaaggtgct   4080     Gcgcgacaac   Atccagggta   Tcaccaagcc   Agccattcgg   Cgccttgctc   Gccgcggcgg   4140     Cgtgaagcgc   Atttctggcc   Tcatctatga   Ggagacccgc   Ggagtgttga   Aggtgttcct   4200     Ggagaacgtg   Atccgggacg   Ccgtgaccta   Cacggagcac   Gccaagcgca   Agacggtcac   4260     Cgccatggac   Gtggtctacg   Cgctcaagcg   Ccagggccgc   Accctctatg   Gcttcggcgg   4320     Ctaaatggca   Ttttgaagcc   Cagtcattct   Ctaaaaaggc   Cctttttagg   Gcccctaagc   4380     Tttcaacaaa   Agaggtgaaa   Tgactgcaaa   Ctgagtctct   Taatagggcc   Attgtcagtg   4440     Agttctgtca   Tcctatttta   Caagattaac   Tcgacgccga   Aaatgggctg   Atgactacag   4500     Gtgaccttgg   Gccgagattt   Ttccaaggcc   Agaagagcct   Ctgctggcca   Gtaacttctg   4560     Gcggctgcct   Ggaaattgcc   Tgcagccggt   Ttccgctcg   Gattagttta   Gaaagccaag   4620     Gggtctgcgg   Tccaaatagg   Ggcgggctag   Ataattaact   Tccctctgga   Ccttcaaata   4680     Cgtctcagga   Gataatgagt   Ttgatgggct   Ccactaaatg   Ctagaacctc   Caggaaaact   4740     Tcgtggtggc   Tggtttaaga   Ggacttggcg   Ggcacagagc   Tctgcatggg   Ggggaggggg   4800     Acagaccatg   Cttttactac   Tgtagaacag   Tagggcagtc   Ttaagagtct   Tagtaataat   4860     Attcctttat   Atgtttgcct   Tttaaatact   Ggaatatatc   Aagtatacaa   Aatgcgctgg   4920     Tgaccacacc   Acttattcaa   Gtgcatctaa   Aatccttatg   Tccctttctc   Agtagcacag   4980     Ccctcccttt   Ttcctatcta   Gaattaacta   Atattctagg   Ataaactgat   Attctaaatt   5040     Tgtttactgt   Tcccacgcgt   Tttaacttta   Gatgcacata   Cccttatact   Attttaatcg   5100     Tcatgaattt   Ttacatttgc   Tcttgaaata   Tatccgtgtt   Gaaatgtgca   Gttctaggtt   5160     Atttttacca   Tatatctagt   Tttctaatgt   Gtcagtaaat   Actttattca   Tttctctgtt   5220     Gatttttttt   Cctcattaca   Aaacagcact   Gtatatagct   Gtgcattttc   Tggttacatg   5280     Gaagtggaat   Tatttggtaa   Atgtgcatat   Tcaacatgaa   Taaaaatgaa   Caatttgctt   5340     Tccagggtag   Tattttaaat   Tttatcccc   Atattccacc   Agcagtgctt   Gagagttatt   5400     Gtttatcagc   Atttcctaat   Gtgaaatcgg   Agtttttcta   Aatgagattt   Ttggctattt   5460     Ggagattttc   Ccgctttcct   Cggaatggtc   Tattcagatt   Ctctacagt   Tttattttat   5520     Gagatttgat   Ttgtaaatat   Tctttatata   Tttgagtttt   Aactttttgt   Cagtatgtga   5580     Caaatatatt   Ctgtcacctt   Gtgggtttgt   Ttttaactgt   Tcgtgatatc   Tttggatgtg   5640     Caaaatttta   Ataatgttgg   Atttatattt   Tttatagttt   Ttgaatgctg   Ccttttcata   5700     Aaggagttat   Ctgacttcca   Ctttccccag   Gagctacagg   Catcaatctg   Ggggaaaaaa   5760     Aaaaaacaaa   Aaacatttag   Gcggcttatg   Tcctgatttg   Gcttgaattg   Gatagtaagg   5820     Cttttctgaa   Atcgctgtaa   Gagtagcatc   Aagagcgagc   Taagggaaga   Cctgataaaa   5880     Gattgatctt   Actttctaaa   Taagcaatga   Ttaacaatac   Ctaaaatttt   Caaagtatta   5940     Caaaagggac   Aaaagaaagg   Gtgaaagagg   Aaagtaatgc   Ctaagataca   Ctgaaagttt   6000     Gttgaaaatt   Gttaagtgct   Ttacatggat   Tatctcgtat   Ctcatattct   Tgtgagatag   6060     Attttattac   Tcttatttta   Aaatggcaaa   Agaggccaaa   Tcaaataacc   Aattcacaaa   6120     Tgttagattt   Tatgacccaa   Acttgtcttt   Ctttaatttt   Tattattcca   Ggagcataga   6180     Ttcaaattgc   Cccgaacata   Cactcactca   Aacctgtaat   Attcttaatc   Acactctctt   6240     Agtagataga   Taagccatca   Cagagagtag   Ttagggtgct   Agtctataa   Tgaagaattt   6300     Ggggaaatgt   Gtcaggacag   Atgcaaaacc   Tgcttgtcac   Ttaatcccaa   Ttggaatgaa   6360     Tttattcat   Gtgtcagttt   Gtgggcctga   Gaaagtcgtt   Tttattttgt   Gtctatatag   6420     Ttatgttatt   Gttaaatctg   Cagcaatgta   Acacgtcctt   Ccctgtcatt   Tttcatgttc   6480     Caagcccaat   Ggattaaaca   Ctcccttagg   Aaaaaccgta   Gtaggtggtg   Atgccagaag   6540     Gaattgtaat   Cctttgcata   Gtgccctagt   Gggttttagg   Tcaagttctg   Ctcattgagt   6600     Gtcttatggt   Atagcactag   Ccatgcatgg   Agtttgagca   Cttacaatgt   Ggcatgtgac   6660     Tgagggagta   Agtgtttaat   Tatatcttaa   Ttagtttact   Tttaaaaact   Ggtgctggat   6720     Tcaattagat   Agcattcaag   Tatacttgga   Acaccttagg   Gacatgaatc   Agaatcatct   6780     Tattctaatt   Acagatcaag   Aattccccac   Gaaaatttat   Tttgatatac   Cataaaagtg   6840     Taaaatacac   Accagatttt   Gaagatttga   Aatgaaaaaa   Gaatacaaga   Tatttaatac   6900     Attctgtatt   Gactatatgc   Tgaaactata   Tttttgatat   Attctgtcaa   Ataggataca   6960     Ctattaaaat   Taactttttt   Aacttttttt   Ttggagacga   Actctcgctt   Tcgtccccca   7020     Ggctggagta   Caatggtgtg   Atctcggctc   Actgcaacct   Ccgcctcccg   Ggttcaagca   7080     Attctcctgc   Ctccgcctcc   Caagtagctg   Ggattacagg   Tgcgtactac   Cacgccaggc   7140     Taattttttt   Gtattttaag   Tagagacatg   Ttggccaggc   Tggtcttgaa   Ctcctgacct   7200     Caggtcatcc   Gcctgcctcg   Gcctcccaaa   Gtgccgggat   Tacaggcttg   Agccactgtg   7260     Cccagacaat   Tttttttaac   Ttttaaaaat   Ggttactgga   Aagataagta   Catgtatgac   7320     Gtattacatt   Ccccccctcc   Tttttttttt   Tttttttttt   Gagacagtct   Cgctctgtcg   7380     Cccaggttcg   Agtgcagtgg   Cacaattttg   Gctcactgca   Acctcagcct   Cccgggttca   7440     Agccattctc   Ctgcctcagc   Ctcccaagca   Gctgggacta   Cactcatgtg   Aaaccatgcc   7500     Caactaattt   Ttgtattttt   Agcagagacg   Gggtttcacc   Atactggcca   Ggcaggtctc   7560     Aaactcctga   Tcttgtgatc   Cacccacctc   Ggcctcccaa   Agtgctggga   Ttacaggcat   7620     Gagccatcgc   Acgtggccac   Attattattc   Tatttgagta   Gtgtcttaag   Agtaacaaac   7680     Tggctttcag   Acacatacaa   Taaagacaaa   Aaaatcctag   Ttcaataaag   Aatgagaaag   7740     Taggataaag   Caaatgaaca   Aatttcccag   Gcccagtgcg   Gtggctcact   Ggcccggttc   7800     Acgccagcac   Tttgggaggc   Caaggcaggt   Ggatcacctt   Aagtcaggag   Ttcaggacca   7860     Gcctggccaa   Catggtgaaa   Tcccatctct   Actaaaaata   Taaaaactag   Ccaggcatgg   7920     Tggtgggcac   Ctgtaatccc   Agctactcag   Gaggctgagg   Caggataatt   Gcttgaacaa   7980     Aggagacaga   Ggttgcagtg   8000       <210>   88   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H2BB     <400>   88   Caaaactgca   Agagatctg   Tattaataat   Atctgggatc   Tgaaagacca   Aaatagatgc   60     Ccctatacca   Actaagacag   Actctaagat   Taagcaaaca   Aagttaccta   Ctggtagagc   120     Attcatggct   Tggctggcat   Ggcaaattcc   Taaattccaa   Agactaccaa   Aaaactcaca   180     Cttgctaaat   Tccttaacta   Taggagctat   Cagaagccct   Cctaactctg   Atttacagtc   240     Cagtccacta   Caactctgat   Tggacagagg   Accgccttga   Cacacattct   Attcttacac   300     Gtaattgtag   Accttaagcc   Attttcagcc   Agctgctaga   Ggcagcacgt   Aaactttgtt   360     Cttatagtc   Accttgtgat   Gtaaagacct   Aaattctacc   Tcattttaac   Caaaatttaa   420     Cctcgaagtg   Aacatgggag   Gtatattaca   Cgtgtttatc   Cattgtgaat   Gcacttggca   480     Cccctcataa   Tatatatagc   Tgtcccccca   Aacgtgctaa   Atatgtatga   Ctctattgtg   540     Taatatatag   Cctatgaggc   Ataaaaataa   Ccaacctgct   Ccttctcccc   Aaagagagag   600     Taattttggc   Aggttctggg   Accatctctt   Cctggcttgc   Aaattagtat   Tgccagtaaa   660     Tctctccttt   Ctactcttta   Gccatcctgg   Tggtcttttg   Gatgatatat   Cagataagta   720     Tatttcagag   Caaagaaaat   Tactaggaac   Agacaggtag   Attacataat   Gataacaggg   780     Tcaatccaat   Acgaaaaaca   Agcaattcta   Aatgtatatg   Caccaaataa   Cagaactgca   840     Aaatatgtgt   Agcaaaacct   Gatagaaccg   Aaaggagaaa   Tagacacata   Catgatttaa   900     Aggtagagat   Ttcaacaccc   Cttccccaat   Aattgataga   Acaacgaaac   Aaaaaaatta   960     Ccaggtgtat   Agaactcagt   Aagtgactgt   Attacttgtt   Ttgatctgta   Aaacaatgat   1020     Aataatagta   Ctcacacttc   Attgagtttt   Ggtgaagatt   Gaatgaattt   Atacttataa   1080     Gaaatttaga   Aatgtggccg   Ggcccagtgg   Ctcatacctg   Taatcccagc   Actttgggag   1140     Gccgaggcgg   Gtggatcacc   Tgaggtcggc   Agttcgagac   Cagtctgacc   Aacatggaga   1200     Aacctcatct   Ctaataaaaa   Tacaaaatta   Gccaggcgtg   Gtggcgcttg   Ccagtagtcc   1260     Caattactgg   Ggaggctgag   Gcaggagaat   Tgcttgaacc   Ctggaggcgg   Aggttgcggt   1320     Gagccgagat   Cgcaccattg   Cactccagcc   Tgggcaacaa   Gtgtgaaact   Ccgtctcaaa   1380     Aaaaaaaaaa   Aaaaaaatct   Tagaaatgta   Actgacatat   Cataagccct   Caaacttaat   1440     Aatcttttaa   Tacatggagc   Tatctattta   Aaataatgta   Cataaggcaa   Catcccaaaa   1500     Gaaaatgggc   Aagaatcatg   Agtaatcaaa   Ccataataga   Agaaatgtta   Tttacaaaat   1560     Gtgcagtctc   Aaacaataat   Tgtcttaaaa   Ataaaaacaa   Caatgagatt   Taattgttca   1620     Tgtcggcaat   Ttgaacagac   Taacacaccc   Actgttcaag   Agcatttgtg   Gaagtcagga   1680     Aaaaacaccc   Tgttggtgag   Agtgtaaaca   Gaccttcagg   Aggcaacttg   Gtaacatgta   1740     Ttaaaaatca   Aaatatgtat   Atcaatggat   Gcatgattcc   Tatctctatt   Tttgccctta   1800     Cagcaatctt   Gtgtgtagag   Aaatactgaa   Aagcattttc   Atggtaacat   Ggtttaaatt   1860     Tttaaaaagc   Gaaggtcagt   Gaataaaggg   Caattatcta   Cttccctaca   Atgaaatgca   1920     Gtaatgaaaa   Taatcattag   Aatctctttt   Attatttaa   Aaggatacta   Gaaaagtgaa   1980     Atacaatctc   Acttatagaa   Gatttacata   Ttggtttgca   Tagacttgca   Caagataaaa   2040     Tttctgtaag   Attggtcacc   Aaaatgtcct   Gaatgataac   Attacaatta   Atgtttatat   2100     Tgtaggggaa   Aagaaaattc   Tgtttttctc   Acccatcagt   Aagttcatgc   Ttgaggcccc   2160     Tctacaaaaa   Gacagattgg   Tcgggtgcag   Tggctcacgt   Ctgtaatccg   Agcactttgg   2220     Caggacgagg   Cgggcggatc   Acgaggtaag   Gagattgaga   Acatcctggc   Caacacggtg   2280     Aaaccctgtc   Tctactaaaa   Atacaaaaat   Tagcggggca   Tggtggcacg   Tatctgtggt   2340     Cccagctact   Cgggagggcg   Aggcagtaga   Atcgcttgaa   Cctgggaagc   Ggaggttgca   2400     Gtgagccgag   Atcgcgccat   Tgcactccag   Cctgggtgac   Agagcaaggc   Tcagtctcaa   2460     Aaaacaaaaa   Aaaagattag   Caagagaaaa   Gcatacaaat   Gttatttata   Taagttttat   2520     Attacatggg   Acccttcgga   Aatgaaaact   Cgagggaagc   Gggaaacctg   Tgaattttta   2580     Tggcaagttt   Tgtgaaatgc   Atagttgtgg   Atatattaga   Ttgacagtag   Gcatatgatc   2640     Taatggtaat   Aaactgaggg   Ggacatagca   Aggcttgttt   Gttaattacc   Tattaacgat   2700     Cagccgagta   Tcagcagaga   Cagcaaaaca   Tcctagtttt   Gagttagaag   Acctaggttt   2760     Ttgttttggc   Tttacaatta   Tgggtattgt   Tttagatgaa   Acatcaagta   Ttcttgattt   2820     Cttatttcaa   Aaataaaaaa   Taaaaaataa   Aggaaggaaa   Aaagaagaaa   Aaaagagaag   2880     Aaaagtgtca   Gagttacttg   Aaccagagta   Actccatttt   Gagtgagggc   Taggaaaatg   2940     Aggctgagac   Tttctgggct   Gcattcccag   Aaagtcagtc   Attcctagct   Tctagatgtt   3000     Tacggttaag   Ggaacaaata   Aataatgttt   Actaaacaga   Ctcagactta   Ggagtgtcca   3060     Gatatcccta   Tatctggaga   Acaaaggcat   Tcttaatttt   Gtttaaagat   Aataatgttg   3120     Attcttgcaa   Aatatagtaa   Ctaagaaaat   Taatccttta   Tcacaaactt   Gtagcagagc   3180     Acatctcccc   Atatatacaa   Gtattgtacc   Tagggtggat   Gccttcctcc   Tcttactttc   3240     Gggaatgtcc   Tgctccgtct   Atggagtagt   Tgtcgtttca   Ccactttact   Ttcttagtaa   3300     Acttgcattt   Actttgcact   Gcggactcac   Cctgaactct   Ttcttgcgcg   Ggatccaaga   3360     Accctctctt   Ggggtctgga   Tggggacctc   Tttcctgtaa   Catatttctg   Gccaccacag   3420     Aagggactat   Agtacagaaa   Ccctgaccca   Acagctacct   Ttgggtaagt   Gttggagttc   3480     Tgtaacaaag   Gaagaaggca   Ggcaggcaaa   Aaatttatga   Aagaacatac   Gacaaaataa   3540     Tttctgcttc   Aaaacttcat   Atttttttaa   Tttttttttt   Tttttttttt   Tgagacggag   3600     Tctcgctctg   Tcacccaggc   Tggagtgcca   Tggcgcgatc   Tcggctcact   Gcaagctccg   3660     Cctcccgcgt   Tcacgccatt   Ctcctgcctc   Agcctcccga   Gtagctggga   Ctacaggcgc   3720     Ccacatcatc   Gcccagctaa   Tttattgtgta   Tttttagtag   Agacggggtt   Tcatcgtgtt   3780     Aagcaggatg   Gtctccatct   Cctgacctcg   Tgatccgccc   Gcctcggcct   Cccaaattgc   3840     Cgggattaaa   Ggcaagaggc   Accgcgcacg   Gccccgtcca   Agttaacctt   Ggctctaaaa   3900     Cttgtcttcg   Ctaacattcc   Agttgatcct   Ctagaactga   Aacagaatag   Cagcagcacc   3960     Accttaagaa   Attgtggtta   Tagctctcct   Tgtgacaaag   Taggtggctc   Tgaaaagagc   4020     Ctttgggttt   Ggaagtgctt   Acataagcac   Tttattagag   Ctagtgtact   Tggtaactgc   4080     Cttagtgccc   Tcggacacag   Catgcttagc   Cagctcccca   Ggcagcagca   Ggcgcacagc   4140     Cgtctgaatc   Tccctggagg   Tgatggtcga   Gcgcttattg   Tagtgagcca   Ggcgagaagc   4200     Ctcgcccgcg   Atgcgctcga   Agatgtcgtt   Gacgaaggaa   Ttcatgatcc   Ccatggcctt   4260     Gtaggagatg   Ccggtgtcgg   Ggtggacctg   Cttcagaacc   Ttgtacacat   Agatagaata   4320     Gctctccttg   Cggctgcgct   Tacgcttctt   Accatccttc   Ttctgcgcct   Tagtgatagc   4380     Cttcttagaa   Ccctttttag   Gggctggagc   Agacttagag   Ggttcaggca   Ttgctattcc   4440     Taaacagaat   Agaaaagcta   Ctaacactct   Ccactacaga   Gtagtacaga   Gaacagttca   4500     Gagcccatgt   Atttatagtc   Ctgagattca   Aatgacggtt   Taagattcct   Cacttctgat   4560     Tggacaaaag   Aaacacggtt   Tcactgaggg   Gtggggttta   Tgcaaatatg   Gaatttatgt   4620     Tatctttttc   Tattggataa   Agcaccaaac   Ataattgacc   Aataggatag   Cttcctattg   4680     Cagccttgca   Gtttgtataa   Aaggatttgt   Tcaggcgcca   Ttccagcttg   Cttgtctttc   4740     Acaggtttcc   Gctgctttca   Taggtcgcta   Tttgcggacg   Tggaaaatgg   Agctaaagca   4800     Aaaacttgtt   Cgtcgctacc   Gggcttgcag   Ttcccaatag   Ggcagagtcc   Gtcatctttt   4860     Tcgaaagggc   Aattattttg   Agccggtcgg   Agccggtgcg   Ccagtgtact   Tacaatacct   4920     Ggccgccgag   Atcttagaac   Tggtgggcag   Cgccatacgt   Gacaagaccc   Gcagcatcat   4980     Cccccgccac   Ctgcagctgg   Ccatccgaaa   Cgacgaggag   Gtcaacaagc   Agctgggcaa   5040     Cgtcactatt   Gctcagggag   Gcgtcctgtc   Caatattcag   Gccgtcctgt   Tgccaaaata   5100     Acagagccac   Gataaggcca   Aggtcaagta   Aacactcaaa   Tcagaaaacg   Tagcttacac   5160     Ttgaaacggc   Atttttcaga   Gccgtccata   Gttacacaag   Aaaggatgat   Aacttgcttc   5220     Tgttagggta   Ttttttgctt   Ttcgtttgga   Ttggtttgtt   Ttgagacagt   Ctagttctgt   5280     Cacccaggct   Ggagtgcagc   Ggcgcgatat   Cggcttactg   Caacctccac   Cccgccgctt   5340     Cacgcggttc   Tcatgcctca   Gcctcctgtg   Tacttgggat   Tacaggcgtc   Tgctaccgcg   5400     Cccagctagt   Ttttgtattt   Tttagcgaga   Cggggtttca   Ccattttagc   Cagggttgtc   5460     Ttgaactcct   Ggcctctagt   Gatcgtccca   Tctcgccctc   Ccaaaatgct   Gggattacag   5520     Gcgtgagcca   Ccgcccccct   Agcctaatgg   Tgttaaaaag   Ttaagtttcg   Agaaaataac   5580     Accttccttt   Agaaagtaca   Ttttagagta   Tacaagtga   Aacttaaggc   Caaccaaaat   5640     Aagacatttt   Gagaacaggc   Agggtgggaa   Tgtgacttgg   Acttagaaaa   Caaagggcaa   5700     Ggaaacttgc   Tgttcgccag   Taacaaaata   Gcatggaatc   Tcattctctg   Aatataagcg   5760     Tttattcccg   Acatgagtct   Gaacgtttct   Ggtggtttag   Tgagtgttca   Ccagcattga   5820     Taacttgcga   Gactgtcagg   Aatgcagaat   Ttcaagtccc   Actcaaactt   Actgaatcgg   5880     Aatttacatt   Ttaaaaatcc   Ttagatacct   Tgttatacac   Tctgttcttt   Gggactggat   5940     Gaactagaat   Tttagacaat   Ttgtcgctgc   Agataactga   Aacgaaaagg   Acaggatggg   6000     Cggtggggca   Actcatccaa   Taagattgtc   Tagtaatgaa   Ccaatcagtc   Tggtcactct   6060     Tcagccaatg   Attttatcgc   Gcgggacttt   Tgaaatatta   Caggaccaat   Cagaatgttt   6120     Ctcactatat   Ttaaaggcca   Cttgctctca   Gttcactaca   Cttttgtgtg   Tgctctcatt   6180     Gcaaatggct   Cgtacgaagc   Aaacagctcg   Caagtctacc   Ggcggcaaag   Ctccgcgcaa   6240     Gcagcttgct   Actaaagcag   Cccgtaagag   Cgctccggcc   Accggtggcg   Tgaagaaacc   6300     Tcatcgctac   Cgcccgggca   Ccgtggcctt   Gcgcgaaatc   Cgtcgctacc   Gaagagtccac   6360     Cgagctgctg   Atccggaagc   Tgccgttcca   Gcgcctggtg   Cgagaaatcg   Cccaggactt   6420     Caaaaccgac   Ctgcgtttcc   Agagctctgc   Ggtgatggcg   Ctgcaggagg   Cttgtgaggc   6480     Ctacctggtg   Ggactcttcg   Aagacaccaa   Tctgtgcgct   Attcacgcta   Aacgcgtcac   6540     Catcatgccc   Aaagatatcc   Agctggcacg   Tcgcatccgt   Ggggaaaggg   Cataagctg   6600     Cccgtttctt   Cctcattgaa   Aaggctcttt   Tcagagccac   Tcacaatttc   Acttaaaaac   6660     Agttgtaacc   Cattcggttg   Tctatgttag   Tttccaggag   Atataaaggt   Gataactaca   6720     Cacaagtttt   Gtaactgcag   Acaagtctat   Caggcctttt   Caaccggttt   Tactgcgaga   6780     Aaacaagctg   Agttactgtt   Ttgcccttgt   Taaaaaattc   Ctaggggtct   Ttttagcatg   6840     Tatatgtgta   Aatacttaca   Tattgaaagg   Ctcctgggga   Caccaccgtc   Actcctttta   6900     Atccacgtga   Caattttagt   Tctgatggca   Gtattattaa   Agctatcata   Aagacaatgt   6960     Gtgtgtagtt   Acctaagtcc   Acaaaaacaa   Tagctgaccc   Caaaattcag   Tattggtttt   7020     Gggctgctgg   Aggtggagtc   Agagctcagg   Tggaagaaac   Tggcctcagt   Acacactgcc   7080     Aaaagtccac   Taaatagatt   Tatgtaacaa   Gtacacaaga   Cttgcgtatg   Accatccaaa   7140     Gattatgcgg   Tcatccttat   Ccagggaatt   Tgagaatgaa   Gggtggcaac   Tgcaaagctc   7200     Ttttacccat   Gtcctctttt   Aataaatatt   Taaaaatatt   Caaatgctga   Tttcatccat   7260     Tttctaaata   Tattagtata   Cttaactgat   Ggggtagatc   Aaggttttct   Ggggatcaaa   7320     Ccttttacaa   Cttgttaact   Attaaaaact   Ataatgtaaa   Attaaaaag   Caaaagtact   7380     Gcagactgta   Aatataaatt   Tataatggga   Aaataaaatc   Aaattccaat   Tttataaaag   7440     Ctgacaaaac   Aacagccatc   Acaaaattca   Gaaaatagca   Tattttatta   Acttctgaat   7500     Atgacactac   Caagtatatt   Ttcctgtagt   Tttgactgaa   Tactctgatt   Ccatcttcag   7560     Atcgaaatta   Ttttgtaatg   Ttgtctatag   Gtaatggaaa   Tagaattcaa   Tctttcctcc   7620     Agggtggctg   Atgataatat   Gttttcttca   Taacttagaa   Gttattcagt   Ttcaaaacac   7680     Attattggta   Atgtcaagta   Agtttttagg   Attgttttca   Aatttggaaa   Atcctctgtt   7740     Aagctccttt   Cacatgtaag   Ttgtaaactt   Tgtaagaatt   Ctttccagac   Tagcttctgg   7800     Ctctatacgt   Ttctactctc   Cactagacac   Tcactctcag   Tgctgggaat   Gtgttttgaa   7860     Tacttagatg   Tcataacatt   Ttatctagac   Ctgcatcttg   Ccaggaattt   Aggtgagtta   7920     Ttccagtgag   Cagtaggaac   Attccttgaa   Gccattcttt   Tttttttttt   Tttgagacgg   7980     Agtctcgctg   Tgtctcccag   8000       <210>   89   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   SLC6A3     <400>   89   Ccacccaacc   Gtaatcaacc   Atccatccac   Ccaggcatct   Acacaccccc   Tttccctctc   60     Accctccctc   Cctatctccc   Tttcttcttt   Cttttgtcca   Tcaatacatc   Cattcattta   120     Ctcatccatc   Tatccaacta   Tccactcatc   Catttattca   Tccaaccatc   Caccactcat   180     Ccattaaccc   Acctgtgcat   Tcatcaatct   Atttatccct   Ttctctctct   Ctcacccttt   240     Tctctctctc   Ctttcatcca   Tccctccctt   Cttctgtcca   Tccatccagc   Cttccatcta   300     Tccattcatc   Ccttatctat   Ccacccattt   Atccatccac   Ccgccccttc   Acccacccat   360     Tcattcatcc   Atctgtaaac   Atattaaatg   Ccactgcctt   Ccatgtacca   Ggcctgttca   420     Aaacactggc   Agaagcgagt   Gagactaact   Cagttcctgc   Tgggacaaga   Gacaatgggc   480     Catctgcctt   Caacagaaca   Cctgctaggg   Aagacctggg   Gagaatgggg   Gtttcaagga   540     Acactggcca   Agggccagaa   Cccagaagct   Ggagtgggaa   Cagectttca   Gtggtgatgt   600     Ctatagggaag   Ctgacatggc   Ataggagcta   Gtgggttaag   Gttggaaagt   Tcatggtgag   660     Aacagaaaga   Aggtagttcc   Agatgaggga   Acaagaggaa   Gtacaggtag   Ggaaggagag   720     Tgaagcctgg   Gaaggcatcc   Caagggccgg   Gaatgtctca   Ggtacccaaa   Ggcccaggca   780     Ggataggacct   Gctttctcta   Atgccctggg   Gacgcccacc   Acaaacgggg   Cacttgaaac   840     Aacagaagtt   Tatggtctca   Ccgctctgga   Ggccagaagt   Ttgaagtcac   Agtgttgcca   900     Gggttggttc   Ctgctggagg   Ctctggggca   Gcatctgttc   Catgtgtgtg   Tctccagccc   960     Ctggtgatgg   Ctggcagccc   Tctgtgagtc   Ttggtttgca   Ggtgcatctc   Ttgatgtctg   1020     Cctccgtagt   Cacacagagg   Tcctgtcctg   Gtctctgttt   Cactgtgtct   Cttttcccct   1080     Tcccaggaca   Ccagtggtgt   Tggattcagg   Gtctcagtgt   Ctctcctctc   Ctcttataga   1140     Gtccctgtca   Tattggattt   Agggcccacc   Ctactcaggt   Atgacctcgt   Cttatctaat   1200     Cgcatctgca   Acaaccttat   Tttcacataa   Ggagtcagga   Cttcagcctt   Ctcaggggat   1260     Acaggtcgac   Ctttcccacc   Gccccaccag   Ccagtgccgc   Agctcacggg   Cccttcctgc   1320     Cgtgagcgtc   Cactcagtgc   Tggcctttct   Gctgctccca   Gtctcggctt   Tttaggccac   1380     Tgcacacgcc   Tctccatgtg   Tctctgtcag   Gcacacagag   Agaactgtgg   Ggcttgtgat   1440     Tgtctccctt   Aggctggaat   Cctgcagact   Cttgagtgga   Gattgttgtg   Ctcctgaatc   1500     Actgggactc   Acaggagaaa   Accaggagag   Agcgggaaac   Aggccaaggg   Aagggagagg   1560     Ccggagcaga   Catggtttca   Ggtggggtcc   Agtggtccta   Acggggactc   Tggacatata   1620     Tcagactgca   Ggtcaggatg   Ggggctttga   Cctcaaggtg   Gtcagggtct   Ggccctgggc   1680     Caccctggca   Caggcttcaa   Tcccaggggc   Cctgggacga   Gggcccagct   Gcccaaggca   1740     Ggccctgggg   Gctccaggtg   Tgagctgtta   Gggcggcaac   Tgcagcgggg   Gtggtggcca   1800     Cccccaaggg   Taaggggcat   Cctatgtgac   Aatggggagg   Gtaggagcag   Cagtaaggct   1860     Gcaggcaggt   Tcagcccttg   Tcgttttcct   Gccatggagt   Tcactcaccc   Acctgaaagc   1920     Tgcgagtgtc   Cttcctgtcc   Acacgcagcc   Acacaggggc   Tcagactttc   Caaagcccag   1980     Ctgctgtgat   Gggtgtgctg   Ccacattacg   Tggtggctga   Ctgcatttcc   Atgacaactg   2040     Gtgaggttgg   Gcctcttttc   Ataggtttgt   Tggccacttg   Ggcactttcc   Cttgctggca   2100     Gtcattcaag   Gtctctgtcc   Acttttctga   Tggggtgtct   Gcctcttccc   Tatggacttg   2160     Tggagttcct   Tctacattca   Gggtgtaagt   Gcccctccct   Cacctgctcc   Ctcaggcact   2220     Ccctgagtaa   Atcactcggc   Acgaggaccc   Cgtgtgcacc   Tgcagtatgc   Tgttccggtt   2280     Gcctgcagag   Cctgcaagct   Cgccagcggc   Cagcgggcat   Ggggctggta   Ccagatgcca   2340     Tccacagctc   Acacgccaga   Gaggcgggat   Cccacatgtg   Gctcctcact   Cctccctgct   2400     Cgaggactgc   Cgtgcctttg   Ttttggggct   Ggggaatgtc   Ctcagctggt   Tcttccccca   2460     Atgccctgat   Cctgggctca   Catgtgaccg   Gtccctgcag   Accccacacc   Tctgagaaag   2520     Gcttcagtgg   Catgggccta   Ggctggacca   Cgacgcactc   Agcaaagccc   Agctgtctct   2580     Gtgaccaacg   Gccatctggg   Ccggcccctg   Ctgccgagct   Gctgggacca   Caggcagagg   2640     Agaccacct   Ggcagaggag   Acccacccag   Cccgggagcc   Cacctctccg   Attgctgggg   2700     Cttaatacag   Tcgcccatga   Ggctgtcgga   Gtccttcaag   Tctcagccca   Catagtgact   2760     Tatggccacc   Cacacagtat   Ctgcctggac   Cccagacctg   Agtggtcagc   Agggatcaca   2820     Cctgggggct   Ccaggtgtga   Gctgttaggg   Cggcacctgt   Agcaggcggg   Gtgtagccac   2880     Ccctgagggt   Aagggacatc   Ctatgtgacg   Atggggacgg   Tgggaggcac   Tagttaggct   2940     Gcaggcaggt   Tcagcccttg   Taggcagccc   Agcacttttc   Ctgccacaga   Gttcactgac   3000     Ccagctgaaa   Ggtgcgagcg   Tccttcctgt   Ccacaccgca   Ccacgtgcta   Cgatgcagca   3060     Gtagcagtgt   Ccccatgtgc   Tgccaggcac   Aaagccctcg   Gtgtggggtg   Tgccctcagg   3120     Cagttcgggg   Cagggctgca   Ggtggggctg   Gcgggagtga   Cgcttgtctt   Atcacaggtc   3180     Actgcctgga   Aggggtgctg   Ccatcctatc   Acaggtcatg   Ctgagggcat   Tggcatttac   3240     Tccaagcacc   Aggataaccc   Tggggtttcc   Ttgggctgtg   Gcctgatctg   Ttggtatcta   3300     Gaagaatcct   Ttaggccaca   Gagcgacgaa   Agatgcttgg   Actgaggacc   Aggacccacc   3360     Aagatctggg   Atggggcttg   Gaagaggctc   Ttgggttggg   Cagtggcagt   Ggtcaggcag   3420     Tgtggttgga   Gtctggacat   Gtggggagcc   Cacaagaatg   Ctgaaaggca   Ggtgaggggc   3480     Tgggggagag   Cggtgcagga   Tggcacggag   Gtccagcctg   Agcaagtggg   Cacgacataa   3540     Ggtgccacaa   Cctgccacag   Gggaccctgc   Aggagtgcag   Acgtgggtga   Gggtcaccac   3600     Tgcacccaac   Actgtgtggg   Agcccaggga   Aggggaaaca   Gatcacaccc   Agcacacctg   3660     Cgtgggagcc   Tggggagggg   Gacaggtcac   Acccagcaca   Cctgcgtggg   Agcctgggga   3720     Ggggggagag   Gtcacaccca   Gcacacctgc   Gtgggagcct   Ggggagggcg   Acaggtcaca   3780     Cccagcacac   Ctgcatggga   Gcgtagtgga   Tgtgttatct   Ctaacgtcta   Ggctttaggg   3840     Gaggccggaa   Ggagagatgg   Gccaagaggc   Atcaggtgag   Gaagctttgc   Tgtgggtggg   3900     Ctggggtggg   Gcagaagctg   Acctcggggt   Gtgagcaggt   Gagctgggcc   Tgtgtaaatg   3960     Gatggggccc   Agcggaaacg   Agacaaggag   Gctgaggcag   Tttttccatt   Gtggatgtct   4020     Tttattgtgc   Ttagggaccc   Acacgatgct   Gaatagagat   Tggtcaacag   Acacggacaa   4080     Cacctgggtt   Gctacacgga   Gcccctcccc   Gaagaggcgat   Ggggaagccg   Ctctctgtgc   4140     Tgactgcagc   Agccagaagg   Cgatggggaa   Gctgtcctct   Gtgtccctcc   Ccagaaggca   4200     Atggggaagc   Cgctctctgt   Gctgactgca   Gcggccagaa   Ggcgatgggg   Aagccgtcct   4260     Ctgtgtccct   Ccccagaagg   Caatggggaa   Gccatcctct   Gtgctaactg   Cagctgcctg   4320     Gcagttcaca   Ggctgacggc   Tcccaccgag   Cattacactc   Cagtccctgg   Agcccacgtc   4380     Cacttgcagg   Ggacagccat   Gactggccct   Gcacggcccc   Tgccctcggg   Cagcacgtag   4440     Gcaggcccac   Cgacttgagg   Catgaattca   Aactatggca   Tccactttcc   Tgtcagtggc   4500     Agagggcagt   Gtgccatgga   Aagcagcttt   Tggccaacat   Ccttcactca   Gtattgctaa   4560     Ttattcttgt   Aaacaaaaac   Tgcaatatca   Gcaagcaggc   Tcgcggatac   Tgcattcttg   4620     Aatttgtttt   Gattcacagg   Taaatatgat   Tttaaaaagc   Cattcgcaaa   Cataaaaaact   4680     Gttgttattg   Atgtggcacg   Cacctgagag   Aaataaaatt   Ccagtggggt   Cccttcctgg   4740     Aggtcacggc   Tcaaggccag   Gcagagtgtg   Gtctgcaggc   Tgcctgcatg   Ggggccctgc   4800     Atgcgtcctg   Gggtagtaca   Cgctcctgtg   Ggggccctgc   Atgcatcctg   Gggtagtaca   4860     Cgctcctgtg   Ggggccctgc   Atgcgtcctg   Gggtagtaca   Cgctcctgtg   Ggggccctgc   4920     Atgcgtccgg   Tccggggata   Ggacaccctct   Ctgtgggggc   Cctgcatgcg   Tcctggggta   4980     Gtacaccctct   Cagtgggggc   Cctgcatgcg   Tcctggggta   Gtacaccctct   Ctgtgggggc   5040     Cctgcatgcg   Ttctggggta   Gtacaccctct   Ctgtgggggc   Cctgcatgcg   Tccagggata   5100     Ggacatgctc   Ctgtgggggc   Cctgcatgcg   Tccggggata   Ggacaccctct   Ctgtgggggc   5160     Cctgcatgcg   Tccggggata   Ggacaccctct   Ctctcaggcc   Gttccctaca   Ccgcaaggac   5220     Ccacaggctg   Cctgagtggc   Agtagcctga   Gctggtttca   Aggagtttta   Tttctctctg   5280     Ctgcaagaac   Ataaacagaa   Tttcctggtg   Agacatacca   Ggacccccat   Cctccaatgc   5340     Ctctgaacag   Actgtgtgtg   Caatgtgtca   Actgaacgct   Caatttacgg   Cctctgctgg   5400     Gagccacgca   Tcgggaaagg   Actttgcatg   Aatttgtggt   Ttcctccatt   Tcaccttctg   5460     Cacagctaaa   Ccaagcagga   Cacttggctt   Tttaatatgg   Gcaaagtaaa   Tggtctagga   5520     Agctactgtg   Agcacgggga   Ttctcagcag   Gtgcgtctac   Aaggatcgtg   Atccccgcct   5580     Gagaacacag   Tgcccctggg   Gcagcctcag   Agccgggagc   Agggagcagg   Gagggaggga   5640     Gcctcacaca   Gacagcatga   Agttagacgt   Ttttctgccc   Tgcagggaca   Acaacggggt   5700     Ggacctcgct   Gcacagatct   Acgtcgttat   Tacagcaaca   Caagacacgg   Cgaggtgcgc   5760     Tcccggcacg   Gaaaggtgta   Aacagtcaga   Agagaggagt   Cttctgcttt   Gttgtttgtg   5820     Ttttcagtag   Aggttgaaga   Gtagaagttg   Ccctcctttc   Tctcgaaact   Tagatttcct   5880     Tggtttgttc   Gtgtctctcc   Cattgcagga   Tgacttcctg   Gggtcttcgt   Ctctgctccc   5940     Tctacacctt   Gagccagtgg   Cggagctgga   Aagaaaacag   Gtttagtcag   Aaaccctggg   6000     Gcgatgcccc   Atttaagagc   Agctgaaggt   Ggctaagagc   Agctgaaggc   Agtgagcaga   6060     Cagtttgcag   Cctcctggcc   Atgtgccctg   Ggagaagggg   Aggctcactg   Ggggcctgga   6120     Ccaacacacc   Cttgacaggt   Gccggggatc   Cgatgcctca   Ctcaaactcc   Tacaaatcaa   6180     Tcattacttg   Attttttaaa   Aagccgcgag   Actgtggttg   Gcgtggtggc   Catggtggcc   6240     Tctggggcgt   Attgatcaga   Tgctgagtct   Gagagatgcc   Gggcaccctc   Agtccgggg   6300     Tggttccaga   Ttgtacccca   Gcgacttggg   Tgtgacgtgg   Tgatgtcacc   Tctcccccac   6360     Gtccctccac   Cttcctgggg   Gcctcagatg   Ctccatctga   Gtgacacgct   Acctctgcag   6420     Ctccatcttg   Ctctctgcga   Cccgcgcggg   Cgcaagtgca   Gcgtgtactg   Actgctcagg   6480     Gactgatgag   Atagacaaga   Gcagctattt   Acaccaccag   Caaatgtcat   Cgcctgctat   6540     Tatgcagctg   Ttagttcagc   Ctgtttgtga   Gcgtcaaagc   Ccctcgatag   Cactaaatgg   6600     Caagaagtgt   Gcttcataaa   Catttccaaa   Caggggcatg   Cggggcttgc   Ttctgacaaa   6660     Accacgccgg   Ccatggaaag   Ccactgaagc   Taccactggc   Cacaccacag   Gctcctctgg   6720     Ccactccacc   Aagagcctgc   Agggacctcc   Tcagccaggg   Tgggatcaca   Ctgcaggcca   6780     Ggggtctacc   Gggggcctgg   Agcagccaca   Gctgatgccg   Gcacaggcag   Catccaggtg   6840     Cagctcgggg   Ctcagtgaag   Gaagctgggg   Tcagggagcc   Cggccaggac   Ccacaccccac   6900     Gggtggccca   Gcggccagag   Ccctagagca   Gaggctctgg   Gtggcagccc   Cacttcaggc   6960     Cagcgatgaa   Gaagccatgc   Ttgggacttc   Agctgtgagt   Cctgttcccc   Ccagggtgaa   7020     Gcagttctct   Gtcctgcccg   Ctgacagaag   Cagaaggtcc   Cctctggagg   Gaggtgtgct   7080     Tgggggctcc   Cagetccca   Cagattaaga   Tcaagccata   Aatgtaaaat   Aaagactaga   7140     Aacagaagac   Agcagcccac   Tctaagtgag   Tccccagaaa   Ccagacctca   Atttgacccc   7200     Aaaggaccag   Agctgttgca   Acagattaca   Ggatggccac   Ataggggact   Ctcagaaaag   7260     Tgacacacgc   Acatcacagt   Gatgagaatt   Tcacaagaaa   Cagcagagca   Cacgcagctt   7320     Cgagagatga   Agtagaaaag   Agaatggctg   Ggctgcagac   Caggggcagg   Gcagtggaat   7380     Gcggagcgtc   Catagctgag   Ctgtggtttg   Ttcacgtgac   Ggacggtcag   Ggaccagtca   7440     Cggtaggtga   Aacgtagcta   Tggatacaaa   Catttctgac   Ctagatggaa   Taatagggat   7500     Cgaatttacc   Ctactgtccg   Aaacaagccc   Caaataaaca   Aaacacacgt   Gccgatgacc   7560     Ttccagacca   Tggacaccag   Accgtaaggg   Tcagtggtcc   Ctgagggaag   Ccaacaagga   7620     Ggcccccctg   Ccaccctgct   Cgctgcctcg   Agggagtttc   Tagattgcag   Cacagggagg   7680     Gtgcagcctg   Gtggactccc   Tgagctgaga   Cgctggaaag   Gagagcgagg   Gaaacggagg   7740     Tggctgcagt   Ttgcaggcca   Gagcgccaga   Gaggaggtgg   Ccacacagage   Agaagacccg   7800     Ggacaatggc   Ccaggacccc   Tgctgagggt   Tcagacgagc   Acatcccgct   Gtgaatgagg   7860     Aggctgggga   Gagatccgcc   Gacaggacca   Gagggaacca   Cctctgatgc   Ccacacaggg   7920     Ctgggcacgg   Tgcctgttcc   Cccagccagg   Agaatgtcat   Gattctcggg   Gatctgcatg   7980     Gggtgtgcat   Aaggtctgc   8000       <210>   90   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HTR1A     <400>   90   Tattcaaatt   Ggttgaaaac   Tactttaagg   Taacaacagc   Atcttatatt   Aatttatagt   60     Tttatatttc   Aatattatca   Agcagtagct   Gacacatgat   Cactgaaaat   Gggttagtag   120     Ggcttcttag   Tcacactgga   Agtgactagt   Aactaacaat   Tccttcactt   Agttgaggtg   180     Ttgatagagg   Ccacaggaag   Gcctgtagaa   Aacagaaagc   Cattgtccct   Agaggaagag   240     Atgccagagg   Aaggagcaag   Ggtcgagaac   Agtaatagcc   Aaaattcaac   Tgaaaaatgt   300     Gtccaattca   Gcattttact   Caacatcagg   Aacacattta   Ggtaacatgt   Tgaaaatgac   360     Aaacttcaga   Tagttcttat   Tctatcaatt   Cctctaattt   Tactcttttt   Ttcttttttg   420     Gagatagagt   Cttgctctgt   Cacccaagct   Ggagtgtagt   Ggcgtgatca   Tagctcactg   480     Taaccttgaa   Ctcctggcga   Tcctcctgct   Tcccctaggc   Ctcaaaaagt   Gttgggttac   540     Aggtaagagc   Caccactagc   Accctgattt   Tatttttcac   Tcttgggata   Atatgtgtat   600     Gtacatacat   Cgcctgaacc   Aagcttcatg   Agcttcagag   Tgctctctgc   Tctggcaata   660     Atggccatga   Cctttgttta   Ctggaggttt   Acccatgctc   Actttgccct   Gcagccatca   720     Ttctgacacc   Agaaagcagc   Agaatgaaca   Aacataacaa   Cagaaacaag   Aggtgttttt   780     Gactacttaa   Gtagggaaat   Aatagagcat   Aataattaat   Tttaacatag   Taatacgtca   840     Tatatacaaa   Accctactat   Ggaagaagac   Ccagccagaa   Aataaaatgc   Ccctctactt   900     Ttaattgatg   Aaccccaaaa   Caatcaactg   Tttcttttga   Aacaggggag   Gttattttcc   960     Tccagctgaa   Tgttgcaggg   Tagacagagg   Aggtagtca   Gcaccaccca   Ctgttttaaa   1020     Aaggcagatt   Ggacccctgt   Tgctttcccc   Agagactgta   Gttttcctcc   Atatatcttc   1080     Aattctgtcc   Atgttagaaa   Gaaacctata   Tgttacctgc   Aggtgccagt   Catagaaaat   1140     Gcatggtttt   Atgcctaaat   Gatatgtgac   Tttctttttc   Cagaggcaga   Ttttttttga   1200     Aagaaatcac   Ctatctagaa   Tgagttttac   Tgttgaaaac   Tacacttatt   Tccctaagtc   1260     Agatccctga   Cctgtaaaga   Agtagcttct   Tttaatcact   Gtatttttta   Actttaattt   1320     Taaaattata   Caaataaata   Caagtaggta   Gagattttga   Gtgaaataaa   Gatgcatgtg   1380     Ttactgacat   Cagttaattc   Tagcattacc   Attattaaag   Tcttttattg   Tcacgaggaa   1440     Aagtgaaggc   Aattttgatg   Catcagcact   Ttccttagt   Ataaatactt   Taaagtaaaa   1500     Agaaagcatc   Aggcactctt   Ttgagatatg   Cagctatttt   Atttctctaa   Attctctatt   1560     Gccttgacaa   Tttagctcca   Gttggatgtt   Ccttctccat   Tcttgtgtaa   Atattccaaa   1620     Gccgaaagaa   Caaatgtcca   Aaagtcattg   Tcacacaatt   Ctgtaaaaga   Cacaaataaa   1680     Tggaagtctc   Aaaacttcta   Atgtaaaact   Tgctggccaa   Gacataattt   Ggatgagcaa   1740     Atttggggtt   Tggattattt   Taaatataga   Ctttgttctt   Aaaatttagt   Gtaacataca   1800     Gaaaaacttg   Gtttctgata   Tggctttact   Tagattatgt   Gagcaaaaat   Gaaactgaat   1860     Tatcaaatga   Gtaatagttg   Tgctggagaa   Gtctatctta   Tcttcttcac   Tgcagaccct   1920     Tctcagcatt   Atacatgcat   Agacaaacta   Ttcccaaagt   Tctaaaactt   Tccctgttta   1980     Gctgggatat   Gatgtctact   Tccagtttag   Aatacagaag   Cagacaccaa   Aggaaagctt   2040     Tgttcagtct   Gacaaacaat   Aaaatggctt   Caactgacag   Agctgtcctt   Tcactttctt   2100     Aattataaac   Aaatgaactt   Ttcactggca   Atttttgcaa   Tctgtaaatg   Taatacggtt   2160     Ctcaaaacag   Caaatgaaaa   Cattcgaaag   Gtacagctga   Agagagaaaa   Gagtagggat   2220     Caattacttt   Gtgaattttc   Tggaaaacaa   Gaccattatt   Cataagaaaa   Ttggaggcta   2280     Gatcaaacaa   Tgacaaacct   Ctagatctcc   Atcatgtagt   Tggaaattta   Catccagagt   2340     Acctaaataa   Cttccctttc   Tggggcagca   Aagattttaa   Ccagtttctc   Ggcaggagtg   2400     Gcaaggcttc   Aagaataact   Gaaggagaga   Aagcctggaa   Tgctgcacaa   Ttcaaagggc   2460     Aaaaaggtgg   Tttccgcaga   Cccttggtac   Agcagaatgg   Tcacgctagg   Gagcaattaa   2520     Tcccataaaa   Gactcagcct   Ccccaggaag   Accacctcct   Aactagtcct   Ttaggaccct   2580     Gctatttaaa   Ctatctgcct   Gttgtcacag   Atagtgctaa   Cctatggact   Atctgggcat   2640     Tccattgaaa   Gcccagaatt   Cctatttgga   Aaacaaagtt   Ctgctaactt   Tgtgtcttgg   2700     Atgtcctgta   Aagcaaatgc   Agcgagtgtt   Gggacacgct   Aaacagaatt   Attccccgat   2760     Ccaaaaagga   Caagagcgtg   Aattaggagg   Aaaaattcta   Catcgtaagg   Ataaaattgc   2820     Tctttcaggt   Tttactgggg   Gagccagctg   Gagccttggg   Cacgcgcgcc   Ctggggaacc   2880     Tttcctcttt   Gccgcccctg   Cgtgtcgccc   Ctttaaagcc   Ttcttggtct   Ctccaatccc   2940     Aagagttccg   Cggcatcttg   Cgccactggc   Taaggcaaaa   Acctcaggtg   Tctacccgcg   3000     Cttcagggcg   Ccccagagc   Taggcggagg   Aacccagatc   Ctgtaagtca   Gcagccggga   3060     Gcgcctagcg   Cgctgcgaga   Gcacagatgg   Ctggggaggc   Gcgcggattc   Caggcctctc   3120     Agcttcccca   Gagcgcaaac   Agcggccggc   Tggcgcctcc   Cgcagtaagt   Aagtggcgat   3180     Gtcaggtcgt   Acacactcgc   Cagctacctg   Tacaaacagc   Gtccgctctc   Tccactgtat   3240     Gattgtcagt   Ttctttggtg   Agtgctgaca   Ccaaggcaag   Cataacaacaa   Gtggtctgca   3300     Caccctcctc   Ctccttgctc   Tcccccactg   Gcccggcctt   Gtacttacaa   Gtccactcta   3360     Aaagatacct   Tctagccact   Tgctttgagt   Ccaaggaaac   Aaaggaaata   Ggggttgtgc   3420     Actgcacgag   Agagttatac   Tcaagtctgc   Gagaagacgg   Ggaatcccgg   Gggcaccgct   3480     Ggcacgggga   Aaagcagcct   Cttccgcctc   Tccggaccag   Cagattcgtg   Cataaggat   3540     Ggcgagggca   Gagagggaag   Caatgaaaaa   Aagaaaagat   Aaaaatgggg   Gaagaaaggt   3600     Gaatatttca   Agggccacag   Ggcgggagag   Atggagcaaa   Ttcccaaacc   Tcaagtccaa   3660     Gttctagaag   Ttgggtgatg   Gggtggagcc   Ccttagtggg   Cgcggcggct   Gtgtgtacag   3720     Tttatttatt   Ttttggattt   Tctgccttga   Actaagcatt   Aaacatccac   Cgcaaagatt   3780     Taggagatag   Aagagagaag   Aggcaattac   Tgggatcaaa   Actgatgata   Caggcgaagt   3840     Ctgagccaat   Gtcgcttctc   Acaaactctc   Tgaatttcct   Gggctctcaa   Cgctcctccg   3900     Ctgggtctcc   Tttgcacaaa   Gggccctgcc   Gtggagcagg   Aagtggggag   Gggaccaggt   3960     Ctgcaagccg   Tgagcggagc   Agagagaaag   Aggagaagtg   Gcgaattatc   Ttaagtgttg   4020     Attccctagg   Gttgggggaa   Gcatagtgaa   Tgggacggat   Cctgtagcct   Cgactggccg   4080     Gctactcctc   Cgtcatcact   Ggcggcagaa   Cttacactta   Atgatcttct   Taaacgcgtt   4140     Ttgaaagtcc   Ttgttgaagt   Atgcgtaaat   Gagggggtta   Agcagagagt   Tggagtagcc   4200     Cagccaattg   Attattggcgc   Ccaacagggt   Gggcatgtgg   Cagctgctct   Cgcagaaggg   4260     Cagaacaaga   Gccacgatga   Agaagggcag   Ccagcagagg   Atgaaggtgc   Ccatgatgat   4320     Gcccagcgtc   Ttcactgtct   Tcctctctcg   Ggccagggcc   Atcttgcgct   Tcgcctcggc   4380     Gttgcgctca   Tttttcctct   Cgaaagaggc   Gggggcacaa   Ggggtaggac   Cagcctcgct   4440     Gggcagaggc   Aagtgctctt   Tggagttgcc   Cactcggtgc   Acctcgatca   Cctccagggc   4500     Ggcgccatcg   Tcaccttgcc   Tcaccgcgcc   Attggcgcac   Agagcacccc   Cagccttgct   4560     Ctccacgccc   Agcctccagt   Tcctgctccc   Cgactctcca   Ttcacactct   Tcttgggctg   4620     Cggggcggga   Gatgctccat   Ggcgggtgtc   Cgctccggtc   Ttctccacct   Ttttgaccgt   4680     Cttgcggatg   Cggaagcgcg   Cagctcggaa   Tatgcgccca   Tagagaacca   Gcatgagcag   4740     Cagcgggatg   Tagaaagctc   Caaaggtgga   Atagatagtg   Tagccatgat   Ccttgctaat   4800     Ggtgcatgcg   Tcggggtccg   Agcggtcttc   Cggggtgcgc   Cagcccagca   Tgggcgggat   4860     Agagatgagg   Aagccaataa   Gccaagtgag   Cgagatgagc   Gcagcggcgc   Gccggggcgt   4920     Cctcttgttc   Acgtagtcga   Tggggtccgt   Gatggcccag   Tacctgtcca   Gcgcgatggc   4980     Gcacaggtgc   Aagatggatg   Aggtgcagca   Cagcacgtcg   Agggcgatga   Acaggtcgca   5040     Ggttacctgg   Cccagtgtcc   Acttgttgag   Cacctgatac   Agcgcggcca   Tgggcagcac   5100     Caacaccgac   Accatgaggt   Cggtgaccgc   Caaagagcca   Atagagataat   Tggccacgtt   5160     Ctgcagggag   Cgctccaagg   Cgatggcagc   Caccacgcac   Gcattgccca   Gcaccgcgca   5220     Gaagatgagc   Gtgcccagca   Gcagagaggt   Gatcacttgg   Tagctgacgg   Tcacgtcgga   5280     Gataccagta   Gtgttgccgc   Cggtctcaaa   Gggagccggt   Ggtgatgtgg   Tgttgttgcc   5340     Ctgaccaggg   Ctgagcacat   Ccatgcctgc   Gcgcccggcg   Cgggaagggg   Gagggaagaa   5400     Aaagcagcgc   Gaagattcgc   Ctcgcccctt   Cccctggggt   Cttccgccct   Tctcctggga   5460     Agtttcggag   Gaagggaatg   Cagagaccca   Agcaggaagt   Tcttactgct   Tcggcgaagg   5520     Gtatctccga   Ggagcagctt   Tcaggcgctc   Cctgggctct   Cgcagtccag   Cgcgttcaga   5580     Agctccagct   Gggaaactgg   Agttggcctg   Aaagcagctc   Caggatctcc   Cggcggcgga   5640     Gagggtgctg   Gaacgtctgt   Ctgtcgctgt   Ccattttact   Ttgccgctcc   Cgaactggct   5700     Gccggagctg   Gagtctcccc   Actagcaaac   Agtctccaat   Cccagaaata   Tctagaaccg   5760     Agaagcccca   Tcctccacgg   Tcactctgtg   Accctcctct   Ccctatttcc   Ttccttccct   5820     Ctctccccct   Ctctcctcct   Ctcttctctc   Tcttctgcct   Ctttcgtccc   Ccttctcccc   5880     Acctgccttc   Cctttcagtc   Tccctcttcc   Tcctcacttc   Cctttattta   Tccctctgtg   5940     Agtcgcttcg   Aaagccaggc   Tccttccctc   Ccactctaac   Cctcccctcc   Taatacttcc   6000     Ccaaccccga   Ggagtgcctc   Tttcctctgg   Gtccccgccc   Tcctctccct   Ctagctcagc   6060     Gtctttgcat   Tcgagtctct   Ttttgtcaac   Agagactcag   Aactcactta   Cacacaccag   6120     Atccctgccg   Gtcagaccaa   Ggttgtaaca   Aataaactcc   Gcctccaacc   Cagcaaaact   6180     Ggggttggaa   Aaacttgggg   Gagggaattc   Caactactcc   Ttgcctcata   Tttactgcca   6240     Aattcttaaa   Tcgtgtcagc   Atcccagagt   Ggcaatagga   Gatgagaaaa   Ggaagcatag   6300     Ggagcctgaa   Tgggaaggtg   Aacagtcctg   Ggtcagtctc   Ccaattattg   Ctaattgatg   6360     Gaagaagacc   Gagtgtgtct   Tcctttttaa   Aaagctacct   Ccgttctcgc   Gccattgcac   6420     Tccagcctgg   Gcgacagagc   Gagactccgt   Ctccaaaaac   Aaacgaacaa   Cgacgacaac   6480     Aacaacaaaa   Cggtacctcc   Gttatcatct   Aacagtccag   Ccttactccc   Tcagggagaa   6540     Tattgcctgt   Gacttttttt   Ttaacgttgg   Ggaaccggga   Gagaacgaaa   Ttataaagga   6600     Cgtgtcaaag   Gacaaggaga   Ggtaaacaac   Tgcatctcga   Aatgaagaac   Aaaactcagt   6660     Gtgatatata   Ttctaaacac   Acacacactt   Ttccatcact   Actacacttg   Taatttcagt   6720     Gacactgcca   Cttcccatag   Ctttgtggct   Agtaaattca   Gggatggaaa   Tattttgcat   6780     Atgtgttcta   Agtgaagcct   Ggcatttcac   Atggcctttt   Gcacttctta   Ccagagcctg   6840     Caaacctctg   Ggggaaactt   Ggtggaatcc   Cggttcgcta   Gccggctagc   Ctctcttaat   6900     Ctcagaaact   Gggttcagca   Cctgggacag   Ttctaagcaa   Tgaggtttta   Tgtcgccacc   6960     Ttctggcaaa   Tgttttagag   Tgccatctgg   Aaacccttat   Gcagaaatga   Agcaagtatt   7020     Gaggaaatac   Aacaactttt   Gagaagagga   Agagagttat   Taaaagacaa   Ggtagtattg   7080     Agttttgtct   Ccttcctatt   Ttctttaaaa   Atttatttta   Gtgccctctt   Ttgctctgaa   7140     Ccttatatat   Caggcctatt   Atatgtttta   Gcttccttcg   Aaagcctgaa   Gtatctgtca   7200     Ttcacaagtt   Ctaactggga   Atgccatttt   Aataaagcta   Ggctaacact   Ttcacctgtg   7260     Ttggttttgt   Gctgtcataa   Cctgaacttt   Ggaactgaca   Taaatttacc   Ttttgttgga   7320     Gaaacgaata   Gtattgcatt   Ttccaaatga   Tttaacattt   Ggaaatgtta   Aatcactgaa   7380     Aataaagata   Cttacaaggg   Tttgttctaa   Gctgtttcct   Ttaacaagaa   Aaacaaattt   7440     Aatcacattt   Gagcattggt   Aaagaatggg   Acttctaagc   Aactacagta   Aacataccac   7500     Acaacatttc   Acttatacat   Cctgattgca   Tgcctgaggt   Gaaaggaatg   Caatctcaaa   7560     Agcagttgac   Actggataac   Atgaacagat   Tcactacaga   Ttgcaataat   Cttaatattg   7620     Tgttcaaatc   Tgagctctga   Atttcatagc   Tctgaattct   Ccaagcccaa   Acaaaagagc   7680     Aatcaccaaa   Gcatcaaaaa   Gaatccagtt   Gggccaatgc   Attacaatac   Aggacagtgt   7740     Gtttggataa   Ggttttgttt   Gttttttttt   Tttatagttc   Agtgctgggc   Acaggtccca   7800     Ctcaatcatt   Tcagcatgcc   Accacaatga   Gcctgccatt   Tgtgatgatt   Catggcattg   7860     Aaaagaaaga   Gataagtata   Catggtaatg   Ctgtttacag   Actctgaaga   Agtcttttta   7920     Agatttgtga   Aggtatctat   Ttccacttct   Aaagtctctt   Cacaaataca   Gaactatatt   7980     Tacagttaaa   Atagagttag   8000       <210>   91   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   CDO1     <400>   91   Ctttagggag   Ggaaatgaag   Tgcttggggt   Taggaaggag   Acttctcaca   Tttagtttct   60     Cataaaatgg   Tttctcatat   Tttagcattt   Tagaatttgc   Tatgatcagt   Gtgtcttacc   120     Tatatcaata   Catacacaca   Tgaacacact   Tttttcccac   Atatactttt   Tacagaaata   180     Atttttattg   Tgggaaaata   Tggtcatttt   Aatcatttgt   Aaatgtgcaa   Ttcagtggca   240     Ttaaatagat   Tcagagtgca   Gtgtacccat   Cgccactatg   Tatacccacc   Aaatttttag   300     Tattcccacc   Aaaaactctt   Tagccattaa   Acaataactc   Cccattctcc   Ctccctccag   360     Gcccttggta   Acctgtgttc   Tacttctgat   Gaatttgcct   Attctaggta   Ccttgtacaa   420     Atggaatcat   Ataatatttg   Ttctttgtct   Ggcttatgcc   Attctcccac   Atacttttgt   480     Tttctaaaga   Aaacatctat   Cagctggata   Aataaagttg   Tgaaagtttg   Aaatgttgtt   540     Catgtcttta   Gaaaaaagag   Aacagatctt   Gtgaaatgtg   Ttgacgtgcc   Ttggacaagg   600     Tagctcatgc   Ctggtgtttc   Ctagaaacct   Tagataactc   Attgtaacct   Ttaaaaggt   660     Aactagttgc   Ccaggttatta   Ctcagaaaat   Gaagtcaaat   Agccaccatt   Tcccacaaac   720     Cttggctcat   Atatggcaga   Gctttttgaa   Gaggggccct   Agaggccttc   Agagactcca   780     Tgaatctttt   Ctgaaattgc   Atgcaaattt   Gttgcgtgtc   Cccttttggg   Agatatagtc   840     Tttagtattc   Agagattttc   Aaagtggtcc   Ataataataa   Ttttgaaaaa   Ggctaagtac   900     Cattgttaaa   Taggataatt   Aattctgtcc   Ccttccttgg   Aacagatgta   Aaaacgcttt   960     Gttcatcaaa   Aagattgtgt   Gagtacatga   Ttcatgaatc   Cacgccaagg   Taagtctctg   1020     Aatcggcttt   Acaaaagaag   Tctgtggctt   Aagaaaatga   Tccttagaat   Ttacatcctt   1080     Aataaaaata   Acgtggtaca   Tttgatttgg   Tggcacacag   Aaaacaccaa   Agcatccatg   1140     Tgtgtttgta   Caagattatc   Atgtaaggag   Gttgaggagt   Ttttcattca   Tttcataaat   1200     Attgaacact   Tactatgtgt   Caggtataga   Ccaaacactc   Aagatataaa   Gtagtaaata   1260     Acacaatgtc   Tctcctctta   Tgggggcttg   Catcctatta   Ctaggattta   Gacaataaag   1320     Gagagaaaaa   Gagaatgaca   Ctttcagata   Accctaagtg   Cttcagagag   Tgcttagaga   1380     Tttcactgtt   Agatagtgtg   Attgggaaat   Tcctctctgg   Gaagatggca   Tctgaactga   1440     Aacctgatgg   Gcaagaatga   Gccagccacg   Taaagagctg   Ggaaaggaca   Ttctaggcag   1500     Agggagccac   Agtgccaagc   Tccagctgca   Ggtaagattg   Gagaaactga   Gtagtatggg   1560     Gtgattggcc   Acctgtctcc   Tcactttagg   Gctactcctc   Ttctaccctc   Aggtctccac   1620     Tcccttttac   Atcccaccta   Cactttagca   Aacagtatga   Ttccagccct   Caatattcct   1680     Tctcactcct   Acaaagtcct   Cttgagccct   Tgatgccatc   Actgccttgc   Ttatgtgcaa   1740     Acatcccact   Gacccaagca   Aacagtaagc   Tctgggagaa   Gcagtacgtt   Ggctcctgca   1800     Taaatgttgt   Tatgggctag   Agggagcagg   Ccaatcacag   Aggcagggag   Agtggtgagg   1860     Ccatctagat   Tgagcctcac   Attcacaaag   Ttcttcacat   Ttacatttga   Ccatcactat   1920     Catacatagg   Gtattatgtc   Atttatgtgt   Gttaaaggtg   Ctatttatta   Agcacttatg   1980     Tatatgtaga   Aaacatgtaa   Ctataccata   Attttgcttt   Ttgttataat   Gggatacaaa   2040     Aaaaatgaga   Agtggcccag   Ccttctttta   Ccttgaaagg   Cttataatata   Aagagaatga   2100     Gttttagagg   Atgattgctt   Gagatcaaat   Cctggcttca   Atcctagctc   Tgtaatattt   2160     Tggctagata   Ccttttggcg   Agtttcttaa   Ccatgctgaa   Tatgtgtata   Tagaaagagg   2220     Aattgtgtc   Taggatggat   Ggtaaaaaga   Gcctccctca   Tacctaattt   Agataatgat   2280     Atatggataa   Gggttttgga   Cttctgagtt   Gatattgtga   Tgggatgtaa   Ctctgtgatc   2340     Aggagaaagg   Ccttccaaag   Gcattcaatc   Taatactcag   Aacctagaaa   Tgttatttca   2400     Tgtggccaaa   Aacaaaacaa   Cttctcagat   Gtgattaagg   Atacaatctt   Gagatggaga   2460     Cattgtctag   Ttcctcaaag   Aaaaaaaggg   Aagtaaatga   Gatgtagaag   Gactaaatcc   2520     Gccattgctg   Gctttgaaga   Tggaggaagg   Atgttcaagt   Caaggaatac   Tggacagtct   2580     Ttaggagctg   Agggaaaaag   Aaacccacaa   Aacaagaaaa   Cagatactgt   Gcagcgtaca   2640     Gaaaggagtg   Tagcccttac   Aatactgatt   Ctagtgctgc   Gaaacagact   Tctgacctgc   2700     Agggctatag   Aataatacat   Ctgcattgct   Ttaaccctct   Acgtttgtga   Taatgtgcta   2760     Tatacagcag   Cagaaatata   Ccaattcatt   Aaggttactt   Ttcagaacta   Ttagtaggct   2820     Caaacaactt   Ataacaatac   Ctaatacata   Gtaagcattc   Gataagtgtt   Aatatctttc   2880     Caaaggatga   Gagaggaagc   Taacatgtaa   Atactaatat   Gagatatata   Aacaatataa   2940     Ccaatgagct   Acacagaaac   Tatttttaaa   Ggactttgct   Aactaaattc   Ccagaattaa   3000     Ttagctctaa   Gattatgaca   Gatattcctt   Aagaagttgc   Ttagagcagg   Aagagcaaac   3060     Tcgaatgcac   Atgcaggctt   Tgcaggtaac   Aaataatgga   Aataggtgag   Tttgggactg   3120     Cagcagatcg   Gggggccgac   Ccatttaaga   Ggcaaacccc   Agcctagcca   Actaatacca   3180     Ataaaaatgc   Agtgcagacc   Aagtgttcta   Gataattcaa   Attttgagca   Gctagaatcc   3240     Ctcaacttct   Atgaaatctc   Cagtttttaa   Atgtcgaaaa   Ccaatccaca   Tttaaacaca   3300     Tacagatata   Gacacacaat   Ttccaggcaa   Aactgaccac   Gtctgagcca   Cactacagcc   3360     Agaggctctc   Agattggtgt   Ctctgaccaa   Ttgtgaaga   Tattaagtcc   Aaaaaggtta   3420     Agttgttttt   Gaatgttttt   Tggctctctc   Atattcttac   Atcataaaag   Catttgtcgg   3480     Ctgggcgcgg   Tggctcacgc   Ctgtaatccc   Agcactttgg   Gaggccgagg   Cgggccgatc   3540     Actaggtcag   Gagatcgaga   Ccatagaatg   Gtgaaacccc   Gtctctacta   Aaaatacaaa   3600     Aaatggccgg   Gcgcggtggc   Tcacgcctgt   Aatcccagca   Ctttgggagg   Ccgaggtggg   3660     Caaatcacga   Ggtcaggaga   Ttgagaccat   Cctggctaac   Acggtgaaac   Cccgtctcta   3720     Ctaaaaatac   Aaaaaattag   Ccgggtgcag   Tggcaggcgc   Ctgtagtccc   Agctactcag   3780     Gaggctgagg   Caggagaatg   Gcgtgaaccc   Gggaggcgga   Gcttacagtg   Agccgagatt   3840     Gcaccaccgc   Actccagcct   Gggcgacaga   Gtgagactct   Gtctcaaaaa   Aaaaaaaaaa   3900     Aaaaaaaaaa   Accatttgtc   Acaggtcttt   Tgtatatcta   Gatctaagaa   Actgatttat   3960     Gtgaagtttc   Tatcatgtta   Atcagaaaga   Caccttcaaa   Ttgtgttcaa   Atccacttta   4020     Tttaaattat   Ttggtaattt   Tagcagtaca   Aaatctttga   Ctatgaccat   Gggacacaga   4080     Catgagttta   Tgttttggtt   Tgttgtggtc   Tggggatcat   Gtacttttct   Aaatcctctg   4140     Cacttccttt   Cattaacaaa   Tggcagagtg   Ccgtaagttc   Ctctattatt   Catagaaaag   4200     Aaatttgtaa   Ggtaagactg   Aaaaaataaa   Atctacagat   Tcacaaaatt   Atcttccaat   4260     Attachagaca   Tacaaagat   Actaaagaca   Tctacattta   Gtcctccagg   Taacaaagca   4320     Aacatttgac   Gtttgacgtt   Tctgttttta   Cttcttgcta   Attacagttc   Agagaccaaa   4380     Ggtttccaa   Aagctatgaa   Aaccctcact   Gacgctccta   Gtataggattt   Aatggaatta   4440     Gaggatagaa   Ctatgagagc   Acttgaaaac   Ttgcctttaa   Aaatcacaag   Actttctttt   4500     Cctcagtggg   Acttttcttc   Tgcagtagct   Gagggcacta   Tttgcttact   Taatgcctta   4560     Taattagcat   Ctgccttaca   Gtagatctaa   Ggttggctt   Atttaagtat   Attactggat   4620     Agcacgtggt   Aggtagcctt   Tttgtccaag   Gcaaacatac   Agcgaacctt   Aaagtaaaac   4680     Ctcagagggt   Ttggtgcccc   Ttagttgttc   Tccagcgagc   Ccgaagttgc   Ctgtaaaaaa   4740     Gggaaaaaaa   Gaaagctgtg   Taagaaactt   Tacaaaagac   Attttaactc   Cttctaaata   4800     Gttctgcttt   Tgtagcagtg   Tatgaaaact   Cagcaagggc   Aagggagcct   Tgttgttttt   4860     Cccgcaataa   Gaatatctct   Tagggtttgg   Aatgtggaag   Ataaagatga   Agcggagcga   4920     Taatgagaaa   Attctgccct   Ggcttccctc   Agaggctgcg   Ctttcattaa   Gactcaagga   4980     Ttgctttggt   Ctccattttc   Acacatgtc   Tatttctgga   Tattctgata   Attaagact   5040     Attcctctaa   Atgacaaact   Tatttcagag   Gtagaagact   Gccctgctat   Attagtgttg   5100     Gttgcctttt   Tatttttagt   Aggaaatgct   Tgtttctcaa   Ggaggaacat   Gttagtatag   5160     Tctattctta   Tttgtggtat   Aaatggcata   Acaactctaa   Gaataagcaa   Cattggcaaa   5220     Caaaacagac   Aatttgcttt   Agttatatca   Tcagaataac   Ctttacaaag   Gttaattatg   5280     Caacttatcc   Ctgttggccc   Agcaaattag   Acctatgcat   Agtaagtcat   Ggcagtaaca   5340     Gttatatcaa   Ataatagttt   Tcactctcat   Ttcccaagta   Aatgaaaaca   Ttttctttaa   5400     Aaacaagcat   Acattttgaa   Atttctcaac   Taatgtttgg   Atctaacata   Ataagttttt   5460     Aaaaataaat   Tgaaaagata   Gtcgctaaag   Ttaataataa   Caatcaagat   Atattgggcc   5520     Tttaccatga   Atatagactc   Atctcattct   Ttgcatacat   Gcagtgtaac   Agtgccaacc   5580     Tacagagcat   Ttaaacctag   Aagaaattat   Actcacattt   Ggagttctga   Ttccaaattt   5640     Actatggaat   Gtcattgtga   Ctttgttttt   Atgtcctgtt   Ctttgatcaa   Aggcatggca   5700     Tgtatcaaaa   Ggtggactgt   Acaagtgaag   Gctcacagca   Ggttccgtat   Ggctgatgtt   5760     Ctctactcga   Tgtaagccaa   Tggaatctaa   Acaatatccg   Ggaaggaaaa   Atagataaag   5820     Gagcctagat   Aacagctgta   Ggtaaaatct   Ctgtgagtca   Tctgagatca   Tgaatcaatt   5880     Gtgatgcaaa   Tggaatagat   Attattaga   Attgaacttg   Cagttaaaga   Tagtaagtga   5940     Cacgcatgca   Ttagcctctg   Ctccttcctg   Aaaaccctct   Ccaatggcag   Taaaaaaata   6000     Aaaaagacat   Caatatacaa   Agacaaaata   Ggaaaagaga   Aaacactaac   Aaaaatttga   6060     Aagcttagaa   Agtaagatgg   Atagctttac   Agagcagaga   Aagctaaatc   Ctaagctatc   6120     Catggagaaa   Accaagaaat   Aacctgattt   Atatcttgaa   Actccaaata   Gcacaggaat   6180     Tgacagcacc   Aggtacttct   Ggaaatgagg   Gtaaagatag   Gctgtagata   Taagaactgg   6240     Tttaaagctt   Gtttatgaag   Tagagtctca   Aaaccctttt   Accaattctc   Tctcttcttt   6300     Cttttcagca   Gcagagtaag   Gtctagtctc   Tagaaagagt   Gtaagagatc   Aacttgggac   6360     Tgatggaaat   Caggtgaaaa   Acaggtgaat   Taaacaaaag   Cttccatact   Gaatggtaaa   6420     Aatccctgct   Ttgtcatca   Cctagctgcg   Agaatgctgc   Cagacaagat   Ttttctttcc   6480     Aggcagaaga   Taggaagcaa   Cttctcagag   Aatctgattg   Gctcaagaaa   Aaagctttaa   6540     Agatattgtc   Gctggaagtt   Cctgaagaaa   Aagtctctgc   Cagactatca   Aaaagtgaaa   6600     Tccagttgac   Aagctccact   Catgttcagg   Gttaccaatt   Aatttttttg   Ttcttggttt   6660     Ttaaatatta   Gcacattgcc   Aaggtcacca   Gacatttgag   Caaggcctct   Agtatgaaag   6720     Acagagggca   Gagcaaacaa   Aaaagcaacc   Tgcaacagag   Actactcagg   Ggaagtgttc   6780     Aaaaacctat   Cattaatgtt   Ttcctagaaa   Taagagaaaa   Taccataaaa   Gggaccataa   6840     Aacaaaaaga   Ggttgaagaa   Acagaaacca   Gaaaagggtt   Ggcaggaaat   Gctgaggaag   6900     Actcaaagaa   Caaaaggaca   Aagacagaaa   Atagaaaaga   Aagagaaaaa   Aaaaaaagag   6960     Gaacagttca   Agaggtttaa   Tatctaaata   Ggagtttcag   Aaacagaatt   Aaaaaaaaat   7020     Tcaaagaaat   Aacctgttaa   Tgttttcctg   Agtcgaagga   Cacgaattcc   Cagatttaaa   7080     Aacccactga   Gtacccagca   Caatgaatga   Gtcatcaaac   Aagatacatc   Actgtgaaat   7140     Ttcagaatac   Tgaggataga   Gagaaggcac   Caaaagagaa   Gatcccaaaa   Gtttctagaa   7200     Agaaaataga   Aagattcaaa   Aatcagaatg   Ggaccaggtt   Tttttaaaaa   Aaaacaaaaa   7260     Aaacaaaaac   Agggtctcat   Tctgctgtcc   Atgctgaagt   Atagcagtgg   Gatcttggct   7320     Cattgtagcc   Tccacctccc   Gggctcaagt   Gatcctccca   Cttagcttcc   Caagtatctg   7380     Ggactacagg   Cacctgccac   Catgcccagc   Taatttttgt   Atttttggta   Gagatggggt   7440     Ttcaacatgt   Tgtccaggct   Gttcttgaac   Tcctgggctc   Aagcaattct   Tccatcttag   7500     Cctcccaaag   Tgctgggatt   Acaggtgtga   Gtcaccacac   Ccggccagcc   Ctaggctttt   7560     Gataagaaca   Ctagaaacta   Aaagacaaag   Gaattaccct   Catggttctg   Agggaagatg   7620     Tttatcaggt   Gataatccat   Aacccagcta   Aattatcaat   Caagttgtag   Gagttgaata   7680     Tagagatatt   Taaatatatg   Gggtctcaaa   Aatttacctt   Ccatggatcc   Tttcttgtgg   7740     Agccattgga   Gcatatgctc   Caccaaaaca   Agggcatcaa   Ccaagaatga   Aaaaaaatca   7800     Tgagatcagt   Aaagagggga   Tccagccaca   Ggaaacagca   Aagggaaagc   Ttgagagaat   7860     Gtaagcctta   Cattgtaagg   Aatctcagga   Tcacagctca   Cccctggcct   Agagatcaac   7920     Gaatctgtgc   Tgaagcagtc   Aagaggccct   Gggagagaga   Tcttcaagaa   Gattaaacac   7980     Acacacacac   Aaaaacaaaa   8000       <210>   92   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   CDH8     <400>   92   Ataacactga   Acatactcac   Ttaggaatct   Gtaagagttt   Ctctggaatt   Taccccataa   60     Tgtggcattg   Ctggattaca   Gaagagatgc   Aatgtatgaa   Tcttctcagt   Cttaatgttt   120     Tcactaacac   Ttgatagtat   Ccacattttt   Atacccatcc   Cataatatta   Gagtgatagc   180     Ttactgtttt   Acatttgcat   Ttttgaaagc   Aaactagttt   Gagttttggt   Tcatttactt   240     Gggcttgcct   Ctgtacctgc   Agcaagattt   Ccatatatgt   Ttttattgct   Catttttttg   300     Tgcattgtca   Tttgcttgtt   Ttatttttca   Tagcttggtg   Gtaagtttct   Tttacctggt   360     Agtgtaatac   Tattccttcc   Tttactcttc   Actagtctta   Cttaaattaa   Attatatagc   420     Tcaacaaata   Ataaaatcaa   Atttaaaaac   Aaaatattga   Attggttaca   Aatttctgtt   480     Aacattttga   Ttataataga   Ataaaaatta   Ctaatataat   Tgacatcatt   Agcattttcc   540     Tttcatcaga   Taaatcattc   Agatttagcg   Gcattgctga   Aatacttgct   Tagtagtcat   600     Agtttgtcta   Tttactctgt   Taactttcta   Tgtgtatgac   Aatattatct   Gtaaataatg   660     Gcacagttcc   Cctcttttct   Ataaagcttt   Aaagctttgt   Tcctgcttca   Gcatttcttt   720     Ggatattggt   Ggtagtcagg   Acttggaata   Tttattaggaa   Ccaaagcaat   Gtggacagcc   780     Tttcttttct   Tattttcatc   Ttaataataat   Ttcccttaca   Attctctatt   Aactacttta   840     Tttagtataa   Aatttgggtt   Gattaccctt   Tatcaattta   Aggacattct   Catttatgca   900     Aaatgcttag   Ttttctgagg   Gtttttatct   Taagtagatc   Atgaacttta   Ccacactttt   960     Taaaaataca   Cctacagaaa   Tgttcatatg   Tatgtatttt   Tgtctttgat   Agtcaattaa   1020     Ctattttata   Aaattatctt   Tctattccta   Ggacgaacca   Tattaaaaca   Agaggtatta   1080     Cttattaata   Cactgttagt   Ttctattgat   Gttttcatag   Caaaaattag   Tgtatctgta   1140     Attttctgtt   Tttactttat   Tcctgccagg   Ttttaagaca   Cacacaacgc   Attttctaga   1200     Ctctgggtct   Tcaggccttc   Ctgcctcgca   Cttgtgatat   Cacctttgta   Tgttccatct   1260     Ctctccataa   Tgactgatgg   Aattcttaat   Ttttttttat   Ggcgtagctc   Agtaagtat   1320     Tttctatcca   Taaactcatt   Aaacattcat   Tattttgaat   Cagtattttt   Atggcaattt   1380     Gaaagtacta   Aaacatgcat   Attttatatg   Tatatatata   Tatatatata   Atgctattat   1440     Tttaaaaaca   Agagctgtgt   Caaactacta   Cagaagacag   Taatctctga   Gaagaaagga   1500     Tgtctttcta   Tctttgtcca   Agccccacac   Atgtagcaca   Gggcttatag   Cataaggca   1560     Tgacagatta   Gatgcattct   Cataataag   Cttttaatat   Aagaatttct   Tatacttact   1620     Ctgcataaga   Cttttctctc   Ccaacggata   Ttgcttcaat   Tctacgcacc   Cgacattaat   1680     Taagtgccaa   Acccctaaac   Ttccaaacaa   Cgagataact   Ttatcagtaa   Gtagcaataa   1740     Accaacaaaa   Atgatttgtt   Tgagtgtgtt   Tcttttgtaa   Tttttatcat   Acctaaacca   1800     Caaagaccaa   Atgtttcttc   Tcttgagatt   Ttagattcag   Tccaaagaga   Aaggatatat   1860     Ctctggaaag   Ctttctggac   Aatgtattat   Gtttatagag   Aaagctatat   Gtgtcttttt   1920     Tttctacttt   Taggtaagca   Tacattaaag   Ttttcgagat   Attatctcct   Catttccact   1980     Aactaatatt   Tccagtaagt   Gaatccatca   Tacttcagcc   Gagaatgaac   Aaactaactg   2040     Aagtggagcc   Tttatttttt   Taatttctgg   Aaatctaaaa   Tatataaaat   Tatcagtctg   2100     Actgaccttt   Tctttctgaa   Atgtatcatg   Tctcttgtga   Ccttcattga   Ctcaggtatt   2160     Gatatataga   Aaaaatcaaa   Gtgtagcaat   Gttttctaga   Tgatccctat   Gatggtaaat   2220     Tttatatggc   Aacttgacta   Ggccacagga   Tgcacagatt   Agacattatt   Tctgggtgtg   2280     Tctgtgttgg   Tgtttccaca   Taatgttagc   Atttgaatca   Atgggctcag   Taaagtagat   2340     Tgccttcccc   Aatatatatg   Ggtctcatct   Aatacactga   Aggcataaag   Aacaggaagg   2400     Ggagaattgt   Tccctttttt   Tctgcctgtt   Tcatctggaa   Tatcttattt   Catcttctcc   2460     Tgacttcaga   Ctgggattta   Catcttatct   Cccttgattc   Tcaggcctta   Agactcagac   2520     Agaactgcaa   Tactggtttt   Cctccagctt   Gcagacaaca   Gatcatagga   Gttatccact   2580     Accataatct   Catgagccaa   Ttcctcctaa   Aaactctctc   Tcaccaaatg   Gctctgtgtc   2640     Tctgaagaac   Cctgactaat   Acagtcccta   Acatatccca   Tgtaagaatt   Tctacaaaga   2700     Ctcttatttc   Tattatcctt   Ttctgttgtc   Cattattaga   Gaagttagga   Agtcagcctt   2760     Tgataaacaa   Attcacttct   Catcttccta   Aactttgtaa   Ttgtccccac   Gaattacata   2820     Gttttcaagc   Caaaaactct   Aggagtttat   Tttagattcc   Atcttcattt   Tgagcatgta   2880     Attcaactac   Tgttactacc   Aattttatat   Ccaaaatata   Tgtgaattct   Gggtatttct   2940     Tctatctgta   Ttccactcc   Ataaattcaa   Gataatatgt   Tccttggctt   Atgataaaaa   3000     Tcttctatct   Aggtttccca   Ctttcattca   Tgtctcctac   Aatctgattt   Tcatatagag   3060     Ccagagtgat   Tatttttaaa   Atagaaatca   Gatcatatca   Taccccagct   Tttagatccc   3120     Ttcaattgcc   Ttctctttta   Cattaagtaa   Acatgagctt   Cttatcttgg   Ttgacaagaa   3180     Cctggataat   Atggtctctt   Cccaggtttc   Cacatctgtt   Gcatctcttt   Cacctttaac   3240     Cactataatc   Tggacctcat   Attcattctt   Gtatatgcca   Ctgattcagt   Ccagcagaac   3300     Aactaacata   Aacattccca   Aaccctttac   Tatggttttc   Cttgattaca   Aaaacttcac   3360     Atggcaactc   Aaatatcatt   Ctgtccactg   Taagtaaaac   Atttagtttc   Ccatccatct   3420     Gttttgttct   Atcgtatcaa   Gtttttttta   Tttccattta   Tttacatttc   Ttccatttta   3480     Ccagctcttt   Gaaaaaaaaa   Aaaaaacctt   Ctctgtcttt   Tcaatgctgt   Attcccagca   3540     Cccaaatgaa   Tgggaaatct   Ttggtacgta   Tttcttaaat   Aaataaggat   Actgattgtt   3600     Tttgtaactt   Ggagaatttc   Atacattgag   Aaacacaata   Atgaagccaa   Ttgagagatc   3660     Ccctcacatc   Accatttatt   Ttcaggtgtc   Aggaccttaca   Actagcatta   Ctttttgata   3720     Ctccctgtct   Aagatttgct   Tccctccagg   Actcattcta   Acacagcctc   Aagaaagata   3780     Tcttgtcttg   Gtagacttag   Ataaatattc   Tttctctgtg   Ctttaaaaac   Actgtctgct   3840     Cagttcttcc   Acaggatagc   Caaatcaaat   Gttttatcat   Tcatttgctt   Ctataattta   3900     Tctaatttaa   Ttccatgtct   Tgaaaggcaa   Gagaagtgtg   Ttgggtatat   Ccttttactg   3960     Ttactagcat   Agtacctagt   Atgtatttta   Tagaaaagaa   Tttttatgtt   Taaagctctt   4020     Tcttaaagtt   Tatttgcaat   Atcattatgt   Ataaataatt   Attattatta   Aattttggct   4080     Ctaacattga   Gccaaaaaca   Tccattcaca   Tactcaacaa   Tcagacttga   Caaagatgac   4140     Agctctcgaa   Ctttagaggt   Taagttaaag   Aaaaattaga   Aaaccattcg   Acatatttgt   4200     Agttaaagca   Gagtaacgtt   Ggaaaggtgg   Ggggggtgat   Cccagtgact   Cttaaaattgt   4260     Catgttccat   Cttagagcat   Aattgttaaa   Atcttcctct   Tatttgtgag   Ggatcatagg   4320     Atggcctgaa   Gttctttgca   Tgtacagaag   Aaatcccaag   Aaattaacat   Ttggctttgg   4380     Ggggtgatcc   Caatgactcc   Taaattgtca   Tggtccatct   Tagagcataa   Ttgttaaaat   4440     Tttcctctta   Tttttgagga   Atcataggat   Ggcctgaagt   Tctttgcatg   Tacagaagaa   4500     Atcccaagaa   Attacaattt   Ggctttggtg   Acctctcatt   Tccttttctg   Gtcctgacct   4560     Ctgagttcat   Tgaagccatg   Gttttccaca   Gtctttctct   Tcagacagca   Tcttgtgata   4620     Ttcctcctag   Caaccctctt   Ctgtaatctg   Tggataataa   Tagaaatatc   Tattatctat   4680     Tagtagggat   Acttgcaaga   Aataatactt   Gcattcaaga   Tgtgaattag   Atggtggcag   4740     Gtaactcaag   Ttggggaaat   Agtacccaaa   Ggcactattt   Tcaccagcaa   Atgcctacta   4800     Accttgagac   Ctagatgaaa   Cttccacaca   Taaaggaagg   Aggagaatac   Atacaaaaac   4860     Acttacaaca   Ttacaactca   Ggagatgacc   Ccaaatacca   Gcatgtaatt   Tctgtttctc   4920     Tcacatattt   Gatgtgtaat   Ttaaccctga   Aaattcctta   Taacgtttct   Gaacttcatt   4980     Tttcctatcc   Ataaaacact   Acaatttggc   Aaacctagag   Tttcctataa   Gcacctaatt   5040     Tctggatctt   Tctgaatgtc   Caaaagtgtg   Ccattggtgc   Tttttataat   Tttccctttt   5100     Agtatttgga   Aaagctgtga   Tttctgttgc   Acccattctt   Gagttcccat   Ctttttggaa   5160     Aatttcaccg   Tgacgtcttc   Ttgagtcttc   Ccatatgggg   Tcccttactt   Cctcctcagt   5220     Acttccatag   Cactatatat   Aacttagttt   Ctatttctta   Tcatcaaaag   Tctcataatt   5280     Acagagataa   Ctgtttagtt   Gaaagttaag   Gggatttagt   Gtcagatcaa   Ccaaacttaa   5340     Acccagactc   Aaatagtatt   Tatccataga   Taaaaaaaaa   Attcaacaat   Tagttcttat   5400     Gagattgatt   Aggtacattt   Tataaataaa   Gaaaataagt   Ttgagaatgc   Tactgtattt   5460     Aatctttctg   Tatcaaccat   Gtagcttaat   Ttctgtactg   Atagatactc   Aataaatgtg   5520     Acagacaaaa   Ttctttttcc   Tcagatagtc   Catcaagtca   Ggaaattttt   Aaattttatg   5580     Tcctccataa   Cgctaggtct   Gtgctcaaaa   Tactaggact   Agatatctt   Caatagcaac   5640     Agtataccat   Gtaatccata   Aatttgtgtt   Gactaaaact   Acaatgacaa   Taaatgtatt   5700     Tttaaatgat   Agatcataaa   Gacatgctct   Tctacaatta   Tcataagaag   Caataattac   5760     Aagggcaaat   Aatacattca   Acactgtttg   Gctgagtaac   Agtgcaaaga   Cactttttat   5820     Agcaaataaa   Acagtattga   Aattgaaaaa   Atatagaaaa   Gttattcctg   Caaagtatat   5880     Tctacaatta   Ttttgtccac   Aaaaaaatac   Aatgacattt   Aaaaagtcta   Agtacagcct   5940     Cacaacgtga   Catatttaat   Tctaatccca   Ggtattatga   Gccattattc   Tgttcacaaa   6000     Taaaaagctg   Cttttaaaac   Cctttaccct   Caattcaact   Tctttcaaat   Tcaaggttag   6060     Attcatgaaa   Acagagagcc   Acaatttcaa   Tttgttggca   Gtgcgtgaga   Tttagagatg   6120     Aaaaattaaa   Actataaatt   Atccccagta   Actgaattgt   Gtattatatgt   Gcatatttat   6180     Atatatgaat   Atatttataa   Atatatgtat   Aaggatatat   Atattctttt   Taatgttgat   6240     Attcatgttt   Aagttgtgca   Tttatagagc   Ttttatagtg   Atgcccgctg   Ttccttatc   6300     Tttttgactg   Acaatgatag   Gatttcagtc   Atgctcagcc   Tttccgacag   Tgccagtgat   6360     Gggatttttt   Tgaaatctta   Ttactggtta   Cactgccctg   Atctcagatg   Gaactttcaa   6420     Tcaaaaaggc   Aatcagaagg   Ttatacattc   Gtgagattcc   Ctgcaaagcc   Agtgatcgca   6480     Taatacaact   Tgttggaagg   Gcctacttgc   Cttcagtcct   Tatgtggcta   Taaagagtaa   6540     Ttggctactt   Agctctcagc   Acccgctttt   Ccttttccaa   Aatacagcat   Agcccagaac   6600     Tctgttgagt   Ctcagtgtgg   Aatccagctg   Ctcctaggag   Atttctaagt   Ctcatgcaga   6660     Gacttgtctt   Actttaagca   Tctgattaag   Cagactctcc   Caaagacaca   Tttgtatctt   6720     Tctaagcatt   Cttgcttcac   Tggtgatacc   Agtaaatcta   Agtttccttt   Tcttctatat   6780     Atacacatac   Acttaactgc   Agattttttt   Caaaacagtt   Tcactttaaa   Gtttacaccc   6840     Tagaagtcat   Aattctgtgt   Ggcaaggtta   Acacttgaat   Ttaaaaatag   Catattttag   6900     Tcatcgtatt   Ataaatgttt   Agaaacttat   Aactatactc   Ataaaaatat   Tgttaagaaa   6960     Tgcccccctt   Aatactcttt   Aatattcata   Tatggatgtt   Taagagacac   Tttgctaata   7020     Tgatttgatc   Aaatcatagg   Cagagtagag   Gctgaattga   Tcccatgttg   Tgtccaatca   7080     Cccagggatg   Catcagttcc   Ctaggtggga   Accttgaatt   Gtgaggtagg   Cagagggaga   7140     Taactttgtc   Tcacttggct   Ccaacttaat   Cattcttctc   Tatttagcag   Agagactct   7200     Tgtttctgct   Atgtcaatgt   Tgatgaaaca   Gacaacaatg   Cacatagctt   Taaaaatata   7260     Gtcatttcaa   Taaagttttt   Aaaatgtgtt   Atttaacaaa   Ttgagcatgg   Gatacttaaa   7320     Tcttagaaaa   Tgttaggaac   Cttattgata   Tcttttggtt   Gggaaagtcc   Tggcaagtct   7380     Attgctaaag   Taaaacttca   Agtcaaaatg   Tgtgtttttt   Atttgtttgt   Tgtgtgtgtg   7440     Tgtgtgtgtg   Tgtgtgtgtg   Tgtgtgagag   Agagagagag   Agagagagag   Aaagagagaa   7500     Agagagagat   Agttcctgag   Atttttagtt   Taattcatga   Cactctaaaa   Gtataggtca   7560     Atcttattag   Gatcaaggta   Ttagtcactt   Tattctatgt   Tacaagacct   Gaaataggct   7620     Tttaaacaca   Aaatgctgac   Actgtggtgg   Caaagaaagt   Cagcaagaga   Tgcaagcttt   7680     Cattctgtgt   Tcctaggcaa   Agagaatact   Taggcgatat   Ttgggcaact   Agtagagcag   7740     Acattatctc   Ctgctcacag   Aaaccactgt   Acgaagatta   Tcctgttgat   Taccaatatt   7800     Tgaggataca   Gattttatac   Tccttaaaaa   Atactgtaat   Tattctgtta   Gacatatttg   7860     Tgtgtctata   Atctttgggc   Acttcaaagt   Acactagaaa   Tgagtctggt   Gttcaagaga   7920     Tacataaaac   Ataataatct   Ctccttggtt   Tggaaggtgt   Aagatagttg   Gaatattact   7980     Attggttatt   Actgcaacta   8000       <210>   93   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PCDHGA5     <400>   93   Ctgcgggtta   Gcgcggagaa   Ggaatatttc   Acagtaaacc   Cagaaagcgg   Agacttactt   60     Gtgagtgaca   Gaatagaccg   Agaacagata   Tgcgggaagc   Agcctctgtg   Tgttctggat   120     Ttcgatactg   Tcgctgaaaa   Tccactaaat   Attttctaca   Tagcagtaat   Tgtgcaggat   180     Ataaatgata   Ataccccgct   Attcaaacag   Actaagatta   Atttaaaaat   Tggcgaatcc   240     Actaagccag   Gtacaacatt   Tccacttgac   Ccagccctgg   Attcagatgt   Tggtcctaac   300     Tcactacaaa   Gataccacct   Taatgacaac   Gagtactttg   Atctcgctga   Gaaacagact   360     Ccagatggtc   Gtaaatatcc   Tgagttgatt   Ctaaaacact   Ctctggacag   Agaagagcac   420     Agtttacatc   Aattggtcct   Cacagctgtg   Gatggcggag   Acccacctca   Aagtggcacg   480     Acccaaatcc   Gaatcaaagt   Cacggatgcc   Aacgataacc   Ctccagtgtt   Cagccaggac   540     Gtgtacaggg   Tcaccctgag   Ggaggacgtg   Ccgccgggct   Tctttgtgct   Tcaagtgaca   600     Gccaccgacc   Gggatgaagg   Cataacacca   Gagatcacct   Actcctttca   Taatgtggac   660     Gaacaagtga   Aacacttttt   Caacttaaat   Gaaaaaacag   Gagaaatcac   Galacaaggat   720     Gatttggatt   Ttgagattgc   Aagtagttac   Actctgagta   Tcgaagcaaa   Agatcctgga   780     Gatctagcag   Cccactgcag   Tatccaagtt   Gaaattcttg   Atgacaacga   Ttgtgcacct   840     Gaagttattg   Tgacttcagt   Atctactccc   Ctaccggagg   Attcgccacc   Aggaacagtg   900     Atcgccttga   Taaaaacgag   Agacagagac   Tctggagaaa   Atggagaagt   Ttactgccaa   960     Gtgttgggaa   Atgccaagtt   Tattttgaaa   Tcttcctcaa   Agaactatta   Caaactagtg   1020     Acagacggcg   Ctctggaccg   Ggaggagatc   Cgagaataca   Atctcaccat   Cacagccacc   1080     Gacgggggca   Agccgcccct   Ctcctccagc   Ataattgtca   Ccctgcacat   Ctccgacgtc   1140     Aacgataatg   Ccccagtttt   Ccaacagact   Tcctacatgg   Ttcacgtggc   Agagaacaat   1200     Cctcctggcg   Cctctatcgc   Tcaaatcagt   Gcctctgacc   Ctgacttggg   Ccccagtggc   1260     Caagtttcct   Actccatcgt   Agcgagcgac   Ctgaagccgc   Gggagatttt   Atcctacgtg   1320     Tccgtgagcg   Cgcagagcgg   Ggtggtgttc   Gcgcagcgcg   Ccttcgatca   Tgagcagctg   1380     Cgcgccttcg   Agctcacact   Gcaggcccgc   Gaccagggct   Cgcccgcgct   Cagcgccaac   1440     Gtgagcctgc   Gcgtgttagt   Gggcgacctc   Aatgacaatg   Cgccacgggt   Gctgtacccc   1500     Gcgctggggc   Ctgatggctc   Cgccctcttc   Gatatggtgc   Cacgcgccgc   Agagcccggc   1560     Tacctggtga   Ccaaggtggt   Ggcggtggac   Gcagactcag   Gacacaacgc   Ttggctgtcc   1620     Taccacgtgc   Tgcaggccag   Cgagcccggg   Ctcttcagcc   Tggggttgcg   Cacgggtgag   1680     Gtgcgcacag   Cgcgtgcctt   Gggcgacagg   Gacgcggccc   Gccagcgcct   Gctggtcgct   1740     Gtgcgtgatg   Gaggacagcc   Gccactctcc   Gctacggcca   Cgctgcacct   Aatcttcgcg   1800     Gazacccgc   Aagaggtatt   Gccagacctc   Agcgaccgcc   Gggagccctc   Tgacccccag   1860     Gcaaaactgc   Agttttacct   Ggttgtggcc   Ttggccttga   Tctcagtgct   Cttcttcctc   1920     Gcggtgattc   Tggcaatctc   Cctgcgcctg   Cgactctctt   Ccaggtcaga   Tgcttgggac   1980     Tgttttcagc   Ctggtctcag   Ctccaagcct   Ggacctgggg   Ttctccccaa   Ttacagtgag   2040     Ggtacattgc   Cctattccta   Caacctgtgt   Gttgcctcac   Aatcagccaa   Gacagagttc   2100     Aattttctga   Acataacccc   Ggaattggtt   Cccgcgcaag   Atctcgtctg   Tgacaatgcc   2160     Tcttgggaac   Aaaatacaaa   Tcatggagcc   Gctggggtcc   Cttttgcctc   Agatactatt   2220     Ttgaaggtga   Gctttaatta   Atttattttc   Acttctggtt   Tttatgtttc   Acctaatttg   2280     Ggtaggaagt   Tccactgcgt   Atttctttgt   Ctgtgagtta   Gatttggcca   Atgttgtgcc   2340     Ttaattgtct   Taatcttatc   Taactgaatt   Ttaagtgttt   Tctctctgaa   Gtgtgagatt   2400     Tatttaccca   Tgattgcaaa   Cctttatcac   Atgagatatt   Gcactgtatt   Tctttttctt   2460     Cctcatcttt   Acattacttc   Tctctgcaga   Tttgttgcta   Ttgagacttt   Aggcaattag   2520     Tttcaccttc   Aggctctttg   Tttatcaaat   Tttagtttta   Cttcctctta   Gaatcataat   2580     Acttcagagt   Aaagagagtc   Ttcattttag   Taggctttgg   Aaattgggaa   Acaaagaga   2640     Aagacttttg   Cataatggca   Tggcttgtta   Atcacagggc   Atgggtagga   Cattgtccca   2700     Ttgacttgaa   Gaccaacact   Cagtaagcta   Aatgtcttgg   Aatcacaaat   Gtatttctaa   2760     Aggacapgca   Atgtttgagg   Tctgaggtgt   Ctgctagaaa   Gagtgcattt   Aacaaatgtg   2820     Agaaatcatt   Ctctaacatg   Cattttaaca   Aattgctctt   Aagaaaaact   Acacattgag   2880     Aaaaatctta   Caacctatgt   Tcacatcatt   Ttctacaaaa   Tattacttaa   Aactttgctt   2940     Ttgaatttcc   Taattatata   Gaatttttat   Tttcttagtt   Ttctatgaaa   Gtgttattaa   3000     Ataaaatgac   Tttctgaaat   Gtccattttt   Ttcaatcaag   Aggtttttct   Atttctgttg   3060     Tcatataaag   Atgatagcag   Taaatatctg   Tctcaacata   Gaaaggtcac   Tcagtacttc   3120     Tcgacaagta   Tctgctcatg   Ctttcctgca   Tggatgatga   Aataaaaccc   Catcctccac   3180     Agttactata   Ctggttgtca   Ctggaactac   Aaatatttga   Acatggtaat   Agaaaaacat   3240     Aaaaatgcat   Agttaaccca   Actcaaacgc   Tgtctgagat   Agtggagaga   Ctttctcaaa   3300     Gtcctcacaa   Gtaacaaaga   Tctttatttc   Ttctgcatat   Gacagctaat   Ataacttaca   3360     Taaatcagta   Ggcctgtttg   Gaaaggtgca   Tggagaactg   Ggtttgtttc   Cttggtattc   3420     Ttatatgcaa   Atagagcacgt   Tttcctaaat   Tttacctaat   Aaggagatga   Aatcttgaat   3480     Cctacaaagg   Taagaatttg   Aatgtcctaa   Tttaatggac   Taaatataga   Taagaggtaa   3540     Ataaaggaca   Taggctcccc   Cgatgacgca   Ttaataataa   Tttttgtaag   Gttatgagat   3600     Ctaataatca   Tattgatctc   Agggattgtg   Gaagtcttgc   Tattcagaat   Taaagctgaa   3660     Ttaacggtca   Taaacaacgc   Tacacagtta   Aacattaagg   Atatggcaac   Attattagaa   3720     Ataaaattat   Aactaaactt   Aggagaaata   Aaaatggaat   Ttgatgcagt   Cactggttag   3780     Gactctgagt   Gtcgctgttg   Accaaagtgg   Gaaagaagct   Gccgcagagg   Cgacccgact   3840     Ctgctccctc   Catactaaac   Acacagacca   Gacaagctcc   Tacgaaaagc   Caacgctcca   3900     Cgcccatttt   Cgtcagggaa   Tatgtaccca   Tcggctttag   Ataaataagg   Aaacagcagg   3960     Ctgaaccaga   Actaagagaa   Aattgggcag   Agagaaggca   Atggcgagtc   Cacctagggg   4020     Ctggggctgc   Ggagagctgc   Tgctgccctt   Catgctcctg   Gggacgctgt   Gcgagccagg   4080     Atccgggcag   Atccgctact   Cgatgccgga   Ggagctggac   Aaaggctcct   Tcgtcggcaa   4140     Catagccaag   Gaccttgggc   Tggagcccca   Ggagctggcg   Gaggcgggag   Tccgcatcgt   4200     Ctccagaggt   Aggacccagc   Tttttgccct   Gaacccgcga   Agcggcagct   Tggtcaccgc   4260     Gggcaggata   Gaccgggagg   Agctctgcgc   Tcagagccca   Ctgtgtgtgg   Tgaactttaa   4320     Catcttggtt   Gagaacaaaa   Tgaaaattta   Tggagtagaa   Gtagaaataa   Tcgatattaa   4380     Tgataacttc   Ccgcgtttcc   Gggatgaaga   Gttaaaagta   Aaagttaatg   Aaaatgcggc   4440     Tgcagggaca   Cggttagtgc   Ttcccttcgc   Gcgggatgcg   Gatgtgggtg   Tgaactctct   4500     Cgggagttac   Cagctcagct   Ccaatctgca   Cttctctctg   Gatgtggtaa   Gcggaactga   4560     Tggacaaaag   Tatccggagc   Tggtgttgga   Acagccccta   Gaccgcgaga   Aagagactgt   4620     Tcacgacctc   Ctcctcacag   Ctttagatgg   Cggagacccg   Gtactctccg   Gcaccacgca   4680     Catccgtgtt   Acggtcctcg   Acgcaaacga   Caatgcgccc   Ctgttcaccc   Catccgagta   4740     Cagcgtgagt   Gttccagaga   Acatacctgt   Gggcactcgg   Ctgctcatgc   Taaccgccac   4800     Ggatccagat   Gagggaataa   Acgggaaatt   Gacctactct   Tttcgcaatg   Aagaagaaaa   4860     Aatttcggag   Actttccaac   Ttgattccaa   Cctgggggaa   Atctcaactc   Tacaatcact   4920     Ggactatgaa   Gaatccagat   Tctacctcat   Ggaagtggta   Gctcaggatg   Gaggcgctct   4980     Tgttgccagc   Gctaaggtgg   Tggtcacagt   Acaggacgtg   Aatgacaatg   Cccccgaagt   5040     Gatcctcacc   Tctctgacca   Gttcgatctc   Tgaagactgt   Cttcccggaa   Ctgtaatcgc   5100     Gctgtttagc   Gtacatgatg   Gtgattctgg   Agaaaatggt   Gagattgcat   Gctctattcc   5160     Taggaatttg   Ccttttaaat   Tggagaagtc   Agttgataat   Tactatcacc   Tattaacaac   5220     Tagggacctg   Gacagagaag   Agacttcaga   Ttataatatc   Actttaaccg   Tcatggacca   5280     Tggaaccccg   Cccctctcta   Cagaaagcca   Catccccttg   Aaagtagcag   Acgttaatga   5340     Caacccaccc   Aatttccctc   Aagcctccta   Ctccacctct   Gtcacagaaa   Acaatcccag   5400     Aggtgtctct   Atcttctctg   Tgacagccca   Tgaccccgac   Agcggcgaca   Acgctcgagt   5460     Cacctactcc   Ctggctgaag   Acacatttca   Gggggcgccc   Ttgtcctcct   Atgtatccat   5520     Taactctgac   Accggtgtcc   Tgtatgctct   Gagatccttc   Gactatgagc   Agttgagaga   5580     Cctacagttg   Tgggtgacag   Ccagggacag   Tgggaaccct   Ccacttagca   Gcaacgtgtc   5640     Gctgagcctg   Tttgtgctgg   Accagaacga   Caatacgcct   Gagatcctgt   Accccgccct   5700     Ccccacapac   Ggttccacgg   Gcgtggagct   Ggcgcctcgc   Tccgcagaac   Ctggctacct   5760     Ggtgaccaag   Gtggtagcgg   Tggacaaaga   Ttcaggccag   Aacgcctggc   Tgtcctaccg   5820     Cctgcttaag   Gccagcgagc   Caggactctt   Tgcggttggg   Ctgcacacgg   Gcgaggtgcg   5880     Cacagcgcga   Gccctgctgg   Acagagacgc   Gctcaagcag   Agcctcgtgg   Tggccgtcga   5940     Agaccatggc   Cagccccctc   Tgtcagccac   Cttcacggtc   Accgttgccg   Tggccgacag   6000     Gatccctgac   Atcctggctg   Acctaggcag   Tatcaagacc   Cccattgacc   Ctgaggatct   6060     Ggacctcaca   Ctctatcttg   Tggtggcagt   Ggctgcagtc   Tcctgcgtct   Tcctggcctt   6120     Cgtcatcgtg   Ctgctggtgc   Tcagactgag   Gcgctggcac   Aagtcacgcc   Tgcttcaggc   6180     Tgaaggcagc   Aggttggcgg   Gtgtgcccgc   Ctcgcacttt   Gtgggcgtgg   Atggggttcg   6240     Ggctttcctg   Cagacctatt   Cccacgaggt   Ctccctcacc   Gcggactcga   Ggaagagtca   6300     Cctgatcttt   Ccccagccca   Actacgcaga   Cacgctcctt   Agtgaagaga   Gctgtgagaa   6360     Aagcgagcct   Cttctgatgt   Ctgataaggt   Agatgcaaac   Aaagaagaac   Ggcgagttca   6420     Ggttagtttt   Ctctttcggt   Aaggatgacc   Agaacatttt   Catttgtttc   Ctttttcatg   6480     Tttctgtcat   Attcagaatc   Agctagttat   Gtaaatagtg   Gaacattatt   Tgctgtattg   6540     Gagattaatt   Ttttttatat   Aattcatgct   Ttctccattt   Gttttcaaat   Tctgttttgg   6600     Gaagtctagc   Tgatatctgt   Agacttaagt   Gaaacaaata   Ccttaaagga   Aagtggttaa   6660     Atataatcat   Tttacccaaa   Tattttgtta   Tattggaact   Gcagttctat   Taatagaaaa   6720     Gatgttttat   Tttatcaaat   Tgttagatat   Attgttctct   Tttgagtgtc   Tgcctagaca   6780     Ccattagtga   Atgtgttttg   Gaaaggataa   Tgtataggac   Tgatatttta   Gtctacctga   6840     Aatttgttta   Aggaaataat   Ttacagtatt   Tacataaatc   Agtggaaagg   Tacagagaac   6900     Ttctgggtca   Taaatatcag   Aaaagaggcc   Gggtgcggtg   Gctgacgcct   Gtaatcccag   6960     Cactttggga   Ggctgaggtg   Ggcggatcac   Gaggtcagga   Gatcgagacc   Atcctggcta   7020     Acacggtgaa   Accctgttct   Actaaaaata   Caaaaaatta   Gccgggcgtg   Gtggcaggcg   7080     Cctgtagtcc   Cagctactcg   Gaaggctgag   Gcaggagaat   Ggggtgaacc   Cgggaggagg   7140     Agcttgcagt   Aagccgagat   Cgcgccactg   Cactccagcc   Tgggagacag   Aacgagactc   7200     Cgtctcaaaa   Taaataaata   Aataaataaa   Taaataaata   Aatatcagaa   Aagtagataa   7260     Aatttatatt   Aatgataaca   Tgtagcattc   Taaagtctgg   Aaagtttgtg   Ttaagccatg   7320     Tagttattgg   Atatgtgggc   Ttgttgagag   Aagaaatcag   Tgtaaaggaa   Ccttaaggtt   7380     Gggcttcgtt   Ctgtgatgta   Aagcctccag   Agagttacat   Actgctgcac   Tcaataaatg   7440     Taaatatgtc   Acacacctgg   Catcttctgt   Tatagataaa   Ccctttactt   Attataatca   7500     Atacctactg   Caatgttagc   Gtttctttaa   Gtgtaggtgc   Aattcttctt   Tattacttga   7560     Gtttaaggtt   Gttattgaaa   Aaaaaagaac   Tcaacttaaa   Gatggttcaa   Aattttaaat   7620     Ttcatatcta   Acgtatgtgc   Tcatcttaaa   Ttaatagatt   Tgtcttaatg   Aaatactggc   7680     Ctatgtgcct   Caaattccag   Gaggatgtgt   Tatgtaatga   Aagaactact   Atatttccct   7740     Tctgcatctg   Atttgctgaa   Gatgattttc   Agatgtttct   Tattaaaata   Ttcttaatcc   7800     Ttcaaatttt   Gtacttttaa   Aaccttgagc   Atcagcttca   Aataatgact   Aaataagggg   7860     Aaaaggtaat   Aaaatattac   Aaatgggata   Gtaagctaca   Ttactcaacc   Acatgaaagg   7920     Ttaattgaca   Cattaaagaa   Cctaagacca   Cttgattttt   Attttttaaa   Cactgttaaa   7980     Gagcattcaa   Gtatatctat   8000       <210>   94   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   COL14A1     <400>   94   Tgggactaca   Ggcacgcacc   Accacgccca   Gctaattttt   Tgtattttta   Gtagagacag   60     Ggtttcacca   Tgttggccag   Gatggtctcg   Atctcttgac   Ttcgtgatct   Gcccgcctcg   120     Gcctcccaaa   Gtgctgggat   Tacaggtgtg   Agccactgtg   Cctggcccca   Cattttttaa   180     Aacaatgact   Ttagggtttc   Agcttttcct   Gtcttttaaa   Acaaattagc   Cattttttat   240     Tctaagaaag   Ggttgtatta   Taaagctgac   Ctactactag   Cttatcagaa   Aaaacacgtg   300     Ggtctcatat   Ctgattctcc   Tatgtagcca   Aaagtgccat   Ttgtaagtct   Actaaatgac   360     Ggatattttc   Tgaagatctt   Ttgcctggaa   Aacaaatagt   Gcattaaaaa   Gcttttttgg   420     Tactctgctg   Gattcagaat   Tattttctcc   Ctacctaggt   Cagtattgat   Gggtgtaata   480     Gaatatttta   Tgtggaaaaa   Tactatgtga   Ttgtttacta   Ctctgggaga   Atgttaattt   540     Ttttcccaat   Gaattaggaa   Atcaatacat   Aatttcatgt   Gtgtatgggt   Tactgtaaag   600     Tattgggtga   Gaggttattc   Agactacact   Caataataac   Caaaaatatt   Tttgaatttt   660     Ctgtaattta   Ttcacttatt   Cattctttca   Ttcaggaaac   Attactgagg   Acttgggttt   720     Tgctgaacat   Tgtatatagg   Tactataaat   Acaaaaatga   Gtagacatgc   Cctgtgaccc   780     Agatatact   Ttgagagtca   Cctttgagcc   Tgaatcctgg   Aagtctccac   Atataggagt   840     Aaataaaaaa   Tcatcgtgtt   Aaaacaggtg   Gcttaatgct   Agaaacctcc   Atccaaccca   900     Agcaccagaa   Tacagataat   Aattcacatt   Tacctatatt   Ctttttccca   Gccacttttt   960     Cttatccaag   Gaaaacacaa   Cgatgaacat   Tgagtttata   Attttcttgc   Ttttttttgt   1020     Tcttaagggt   Tgtttatgtt   Tttaaaaaaa   Tgaacttcat   Taaaacagca   Ccaagtttta   1080     Tataatcttc   Taggacttgg   Ttgttttcat   Ccagtattaa   Tattattaag   Tttctttcaa   1140     Atgtttgtgt   Atagttgtga   Ttcattcatt   Tatcacagct   Tcataaattt   Ccagaccacc   1200     Aattatttat   Ctattttctt   Gtctgtgggc   Ttttgggtgg   Tttccatttt   Tgttttcata   1260     Aggtggttatta   Ctgtgaacat   Tctcatagca   Tctcctgggg   Gtccaagtga   Aggagtttcc   1320     Cttaggaatc   Cacttaggag   Aaaaattgct   Gagtcataag   Aaaggtgaat   Gctcaacttt   1380     Acaaagtcgc   Atctaactag   Cctccaaatt   Ggttgaagta   Aaatgtaaaa   Gtgatgcata   1440     Tgccgggtgc   Ggtggctcat   Gcctgtaatc   Ccaggacttt   Gggaggccgt   Ggcaggtgga   1500     Tcacttgaag   Tcaggagttc   Gagaccagtc   Tggacaacat   Ggtgaaactc   Catctctatt   1560     Aaaaatacaa   Aaattagccg   Ggcatggtgg   Tgcatgcctg   Tagtcccagc   Tatgcgggag   1620     Gctgatgaga   Gagaattact   Tgaacacagg   Aggcagaggt   Tgcagtgagc   Tgagatccta   1680     Cgactgcatt   Ccaggctggg   Cgacagagcg   Acactctgtc   Taaaaaaata   Aaaaagcggg   1740     Ggtcagggga   Gatgtatagt   Aatcaatatc   Ttctccaaca   Cttgacgttt   Gaaacttctt   1800     Aattttgatc   Aaatgagtgt   Tttatttgtc   Attgatacta   Agtagtctac   Attgctgcaa   1860     Agctagtaaa   Ctttaaagca   Cagaaaccct   Aagaagtagt   Ttgccatcct   Aacttactac   1920     Atcactgtct   Ttataatacc   Caggatgtct   Tgaaactttt   Accttacaat   Tctgtgactt   1980     Gagtgaggcc   Aggattatta   Ggaattggta   Tgacatattc   Aggaacatchc   Aacaaatgat   2040     Ttattaagtg   Cctactatgg   Ccagtcactt   Aatatttggc   Caacagcagt   Aagtaagaca   2100     Gatccctttc   Tccctttgtt   Tatgaagctt   Gcatattctt   Tggggagaca   Gacaataagt   2160     Aagttatata   Aatgaaatag   Ttaatttag   Ataggggtaa   Gtgctaagga   Gtaaataaaa   2220     Ctgaatgagt   Gatagagaat   Gaccaggttt   Cgagaggtga   Aagaaaaacg   Gggcttccgg   2280     Gtctacaatt   Ccagtgaggc   Accattaaca   Ttacaatcta   Taagaacagc   Actttctgag   2340     Tttaggagtg   Caacagccct   Gagcaaaagc   Ctctgcaaac   Ctgatggttt   Gagttaatgc   2400     Ctaaagtatg   Ggaatgagcc   Agccctagag   Aaatctggaa   Gaaaagcgtt   Gcagagaaaa   2460     Caggaagtct   Aaaggaacca   Agattgtaaa   Gatcatagtg   Gttaagagtg   Tgggctctgg   2520     Ggacataaag   Tccaggttta   Ggccgggcgc   Agtggctcac   Acctgtaatc   Ccaggacttt   2580     Gggaggccga   Ggcgggcaga   Tcacctgagg   Tcaggaattc   Taaaccagcc   Tggccaacat   2640     Agtagagatg   Aaactccatc   Tctactaaaa   Atacaaaaat   Taggccaggc   Atggtggcta   2700     Acacctgtaa   Tccaagaact   Ttgggaggcc   Aaggtgggga   Aatcacgtgg   Tcaggagttc   2760     Gaaaccagac   Tggccaacat   Ggtgaaaccc   Cgtctctact   Aaaaatacaa   Aaaaattagc   2820     Tgggtgtagt   Ggcaggcacc   Tgtaatccca   Gctactcggg   Aggctaaggc   Aagagaatca   2880     Cttgaacccg   Ggaggtggag   Gttgcagtaa   Gctgagatca   Tgccactgca   Ctccagccag   2940     Ggtgacagag   Tgattctgtc   Tcaaaaaaac   Aaaaacaaac   Aacaacaaca   Aaatacaaaa   3000     Attagccagg   Agtagtggcg   Ggcacctgta   Atctcagcta   Ttcaggaggc   Agaagcagaa   3060     Gaatcgcttg   Aacccaggaa   Gtggaggttg   Ctgtgagctg   Agattgcgcc   Accgcactcc   3120     Agcctgggcg   Acagagcgag   Actgcgtctc   Aaaaacaaga   Ataaataaat   Gaagtccagg   3180     Tttagattcc   Tgctgtaaca   Ctcaggagca   Catccagtta   Ctcagtctct   Ccaggcatca   3240     Gtttccttat   Ctgtaaaagg   Gggataacag   Tacctactct   Atttgactac   Tgtgagggtt   3300     Aaattagatg   Atgcaggtaa   Aatgcttatc   Cctgtgcctg   Acccataata   Cctaatcaat   3360     Aattgaatgt   Ttctcttgtt   Ttcgtaccta   Ctaaacaaaa   Gagaaaatgc   Actctagaga   3420     Agtgatttgc   Cccaaaactc   Acaccaacta   Atgtgtagct   Gggactaaaa   Ttcatgctca   3480     Gaaattctca   Gcccaatgct   Tttcttcagc   Ccatcttcta   Caccttagtt   Ttctcatttt   3540     Taagtgggat   Aataatctca   Tgtgaagtat   Tgtagtaatc   Tcttattaag   Gctaatgaat   3600     Gaatacatgt   Aaagctttag   Tacagtatct   Ggcacctagt   Aggtgctcct   Aaattaacta   3660     Taggtattgt   Tatcattatt   Aatactatat   Tatgttaatt   Acctgtcatc   Ttggcaggcc   3720     Cacactaatg   Cacaagaaca   Ttacattgtc   Tatacgttta   Tatcttcacc   Agcaatatgc   3780     Attttagctg   Ttctaattat   Cataagacaa   Taataaaagt   Gtgatatagt   Ttgtctctgt   3840     Gtccccactc   Aaatctcatc   Tggatttcta   Atccccacat   Ttcaaaagag   Ggaggtgatt   3900     Ggatcatggg   Agtggtttcc   Cccatgctgt   Tctcgcgata   Gcgagtgagt   Tttcatgaga   3960     Tctgacggct   Ttataaggcg   Ctctcccccc   Tttgctttct   Cttctccctc   Ctgccgcctt   4020     Atgaacaggg   Tgactgtttc   Cccatcggcc   Atgattttaa   Gtttcctgag   Gcctccccag   4080     Tcatgctgaa   Ctgtgagtca   Attaacttc   Tttcctttat   Aaattaccca   Gtctcggtta   4140     Gtatctttat   Agtggtgtga   Gaatggacta   Atacactggc   Aatatgcatg   Ttagttgttt   4200     Taattgtcat   Aagacaataa   Tacaagtatt   Gaagaaatac   Atatgataaa   Ctctatattc   4260     Aattgagtac   Ggtaaaggaa   Atcacccatt   Ctgttgcttt   Ccctatattc   Ctcaggtact   4320     Gagaaagaaa   Ttaacgggtt   Ggtataaaat   Gtagctttgc   Tggccgggcg   Cggtggctca   4380     Cacttgtaat   Tccagcactt   Tgggaggcca   Aggcgggtgg   Attcctgag   Gtcgggagtt   4440     Caagaccagc   Ctaaccaaca   Tggagaaacc   Ccatctctac   Taaaaataca   Aaattagccg   4500     Ggggtagtgg   Cgcatgcctg   Taatccaagc   Tactcggggg   Gctgaggcag   Gagaatcgct   4560     Tgaacacggg   Aggcggagga   Tgcggtgagc   Ggagatccgc   Cattgcactc   Cagcctggat   4620     Ttctggctgt   Aaattgggag   Aaagcaaaaa   Taattttgca   Ctggatcctt   Attcagctac   4680     Ctagctttta   Aaactaaaag   Ttataagtaa   Ataacttccc   Aatctttaaa   Acttaaaatt   4740     Tcatacagaa   Taattttaaa   Acactgctta   Atattatcta   Cttactacct   Tatcagactc   4800     Tccgcagttt   Tacaggctgt   Tagaaaagca   Atcaaagtaa   Tcaacatata   Tgtactgagt   4860     Attttataca   Gcaaacactc   Tttctcagga   Tatattggag   Atttagtttt   Gatgacaaag   4920     Gaggttcttt   Tcctgaacac   Accttaatta   Agacattatt   Tgtcttttga   Gggcagcctc   4980     Ctaagtctgt   Acaggtttta   Gagattcatg   Ccagaattat   Gtaagcaaca   Ccacccccat   5040     Gtgcttctgt   Tagcacaagc   Tttctgcggt   Cagagatgga   Agcacaggct   Gctgtcatgg   5100     Aatgcactga   Gcaaaataaa   Ggagtgctct   Gtaaagaact   Tggctgaagt   Gtctattttc   5160     Ttagttccag   Gacctgacaa   Ctctcttttt   Cttttgcatg   Tcattctgct   Tatgtgaatt   5220     Tttctctttg   Cctcttggga   Ctccctatct   Tattctaaaa   Tgtgcttttc   Tcccttgggg   5280     Tgaaatacta   Aatttcttga   Agtctgagat   Gactgggtcc   Acagaggcca   Attcataatt   5340     Gaaacttaat   Ataggtggcc   Attgacactt   Cttgagattc   Aatcccagag   Gatggaagaa   5400     Agagagaggg   Aagatgtatg   Ctctgttacc   Tcaatgtttg   Ttgttgttgt   Tgttgttgtt   5460     Tgtttgtttt   Ttgagactga   Gtctccctct   Gttgcccagg   Ctggagtgca   Gtggcgtggt   5520     Ctcagctcac   Tgcaacctct   Gcctcccagg   Ttcaagcaat   Tctcttgcct   Cagcctcccg   5580     Agtagctggg   Attacaggca   Cgtgccacta   Tgcctggtta   Atttttgtat   Ttttagtagg   5640     Gacagggttt   Caccatgttg   Gccaggctag   Tctcaaactc   Ctgggctcaa   Gtgatccacc   5700     Caccttggcg   Tcccaaagtg   Ctgggattac   Aggcgtgagc   Caccgcaatt   Ggcctgttaa   5760     Ctcaattttg   Aaaatgtgtg   Ggtaagtgtg   Agcccaggtt   Ttaaaagatt   Tggatatttc   5820     Tgcagctgtg   Aaaggtaagg   Aagcagaata   Ctagccccta   Ctcctgaacc   Caaaaaaccc   5880     Atggatggtg   Tgacatggaa   Atatcaagac   Tagttaatta   Ttgagcagag   Agtctcccag   5940     Gtctggtatg   Tagcagcaga   Aaatgagtgt   Gtgagaagct   Ctaaagaaga   Tgggactcac   6000     Caaatgtcag   Accagcctgt   Ctgtgttaga   Gaaagaaccc   Ctgttttttc   Agatttttct   6060     Cttggccatc   Ctggactaca   Caagatgtta   Aaaactttct   Agtgttttca   Tgcttcatgt   6120     Ataccatctc   Atgccattaa   Agtatgtatt   Attttttatt   Gcaagcacag   Gacaatccac   6180     Tcattcaatt   Ccctacttac   Ccatccacct   Tctttgcttt   Ccatcttctc   Atcagtactt   6240     Cataccctcc   Caacttatta   Tttttgtttg   Tttgtttcct   Atatattttc   Ctgcacatag   6300     Taggtgctca   Cttcccaact   Tattacataa   Atggaaacaa   Aaatatgaaa   Tcatagaact   6360     Ttttttgatc   Agtaagtgac   Cattttttaa   Tcagtaagtg   Tgctgttttg   Ctatgtcctt   6420     Aggaactcag   Aaagtctttg   Aaataactca   Tactgatact   Taatattcat   Tgcacaccaa   6480     Atatatgaca   Gctcctctac   Taaatgtttt   Ctacagatag   Tctcatttaa   Tcctcacaac   6540     Aagcccatgg   Ggtaggttct   Aataaaatcc   Tctttttttt   Tttttttttt   Gagactgagg   6600     Ctggagtgca   Gtggcgcgat   Ctcggctcac   Tgcaagctcc   Gcctcctggg   Tgcacgccat   6660     Tgtcctgcct   Cagcctcctg   Gtagctgaga   Ctacaggcac   Tcaccaccac   Gcccagctaa   6720     Ttttttgtat   Ttttagtaga   Gatggggttt   Caccatgttg   Gccaggttgg   Tctcaaactc   6780     Ctgacctcaa   Gtgatccacc   Agcctcggcc   Tcccaaagtg   Ctgggattac   Aggcgtgagc   6840     Cactgtgccc   Tgccaaaatc   Ctctttttat   Aggcaaggaa   Ctcagctctc   Taggaaggtt   6900     Aagtcagtgg   Tacaaggtca   Tgtactggac   Aagccatggg   Gccaggcttg   Gaacccagtc   6960     Actgactact   Gagggcatct   Gcctcctagg   Accatccagt   Ttgcccagaa   Gcacaaggtc   7020     Actcatgcac   Atgctggaag   Aagacaatct   Agagcaagag   Cttgttcttt   Gggagcaccc   7080     Cactttcttt   Ttcttttgtt   Gttgtttttg   Agacagagtc   Tcgctctgtc   Acccaggctg   7140     Gagtgcagtg   Gcacaatctc   Agctcaccgc   Aacctccacc   Tcccaggttc   Aagtgattct   7200     Cctgcctcag   Cctcctgaat   Agctgggatt   Acaggcatgc   Accaccacac   Ccaactactt   7260     Tttgtatttt   Cagtagagat   Agggtttcag   Caggttggtc   Agactggtct   Tgaactcctg   7320     Acctcaagtg   Atctccctgc   Ctcagcctcc   Caaagtgctg   Ggattacagg   Catgagccac   7380     Tgcacctgga   Cctcactttc   Tcggtgttgc   Tgttggagac   Cacacccagc   Cccctcctga   7440     Gcagcaggga   Tctagggctc   Attcctgtaa   Cttggtggtt   Gccattacat   Ccttgctttt   7500     Cttctgcagg   Cattggtgat   Tgcacctgct   Ttcctctttc   Ttctcaacat   Cactgcctat   7560     Catttggttc   Attgctgggt   Tttccttgct   Cccaaactgg   Gagtgtagta   Gcttattttt   7620     Cagetcctt   Tgtaggtttt   Attctggaag   Ccaacaccca   Gaccctttgt   Ttttatccat   7680     Gtattttgtt   Tcatttcatt   Caacacgatg   Attgactctt   Tgatttgctg   Gagacctttg   7740     Ctagtgtaaa   Tattaaattg   Caacaccaca   Ggtgggcaac   Caaaaagtaa   Cctggcaagt   7800     Cgtggagctc   Tagagtattg   Gaactacatc   Aatgaattct   Tacatgccca   Gggcctaaaa   7860     Cggtcagcac   Aaagcctctt   Gatgagcatt   Tgttaatgaa   Agtatatgtt   Tgtaaacatt   7920     Tctgcaaatt   Tgtaaatatc   Ccttgccctt   Cctgaaatgt   Aagtgggcct   Gaaattgaag   7980     Tcttgctgaa   Gtctgtttct   8000       <210>   95   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   SPAG6     <400>   95   Atataagggt   Ggagaagata   Gtaccgacct   Tctctgacac   Aagcccaaca   Acgccaacat   60     Tttaaagggg   Tgggaggtat   Tgagcgggag   Ggctgaccgg   Catctggagc   Agggcgctta   120     Gtgttttcca   Gctcgtgatg   Caggctttgg   Gcacagtttt   Gaattactta   Agaaaacgca   180     Cgcaagtcca   Aacggaagat   Atttatatca   Cactcacaca   Ccaagctcca   Ataatttgtt   240     Tttatgcatg   Tcaccaccgc   Cttagaaaac   Ggcatgctgc   Atttcggact   Tatacattga   300     Aagcccccat   Ttttagtatc   Aatcactttg   Cactacatgg   Tgccttttgg   Ggaagcaaaa   360     Tttatcgtgt   Gtggaatccc   Ccaatcacgg   Gtttctttgg   Aagtggaaaa   Gattagttcc   420     Atctcttcat   Cctctgaatt   Actggaaagg   Aagacaggta   Caggtatata   Tttaggagtt   480     Tggggccagt   Taaaccactg   Tcatcttgac   Attgacctta   Atactaaaaa   Gaaaaacttt   540     Aaaatgcaaa   Gagttgactt   Taaaaggttt   Gaaaagcgaa   Gaatagggag   Taaggcataa   600     Acacaaaaca   Tgcatagaaa   Tttcaatctt   Cccttcccgg   Atggaagtgt   Gcaagtctct   660     Tctgctctgc   Tgacaaactt   Gatgaaataa   Ctgggtggtc   Ggctcagacc   Taaaatcctg   720     Acattatttc   Ccaaaagagg   Cgcgatgcac   Catttaagat   Agtcatgttt   Actttcatca   780     Ttataggtaa   Tatttctgtt   Ccaccaactt   Ggttatggac   Taagtaatgc   Ctttattttt   840     Aattccagta   Tgtaactatg   Aattatttta   Gtaattttaa   Atttagtgtt   Tgcaaaatga   900     Tatagttagt   Ctcataactt   Cagtaattac   Atgcaattgc   Ccgttgaatg   Ccttcttaaa   960     Tgctaacaat   Gattttgggg   Aaaaaattat   Tttaggggag   Ggaaatttca   Tagctgcata   1020     Gaactcagct   Aatttttatt   Aaaaacaaga   Agccttttgt   Tatttaaatg   Atgttttagg   1080     Tattctcact   Tcttcgccta   Ctttaccata   Agtccctcat   Ctttgccccc   Aaaacactaa   1140     Tagcacttag   Agcaattaca   Gcccttaaaa   Cagtggcaga   Ctgcagtaca   Tgcccattga   1200     Atgaatgcag   Gctgcggtat   Atatgctggt   Agaatgaagt   Gatgtctatc   Tgctactaga   1260     Cttcatgtcc   Tggaagaaag   Gcacattctg   Tttatagcaa   Ggtgtttgac   Acacattaat   1320     Aatgaatacg   Tgttaggctt   Gatgcagaat   Atatataaac   Acttgattca   Actcaatgac   1380     Agttttaaaa   Tgcagatatt   Aatatctaat   Tagcatatat   Aaatctttaa   Attttaaaat   1440     Tcagctagga   Actgaagaaa   Aaatacatgg   Gtgttaaaat   Tagcaaagct   Tcttttaggt   1500     Atgtatagca   Tatattccca   Tgataatagg   Attttctgaa   Ttctcaaagg   Aggtatgcaa   1560     Agagaaacaa   Caagatttta   Aaactggctt   Tattttgttg   Tcattttcag   Tctcattttc   1620     Ataaataaag   Gaggaaatat   Ttgaaaaagt   Gattttgaag   Ttacatatta   Tgattagcgt   1680     Tttacaaaag   Tagccaaagg   Cttccaaaca   Aacctttcat   Ggaaacactt   Ttttgcaagt   1740     Tgttcagcta   Atggttcatt   Ctcaatcaaa   Tgtatagtct   Tatgtgccag   Ttacattgta   1800     Tatctctaaa   Gtcagctggt   Actttaagaa   Cagtaatctt   Cctgtaatac   Tttttaaaat   1860     Accgaagtat   Ccctttgaat   Tgttttcttt   Ttcattgctt   Aactgttagt   Ttagaggtgt   1920     Gtatgtgatc   Atgggacatt   Catttaactt   Tagaaaacag   Aatagtattt   Tgttttagag   1980     Ttagtacatt   Gaaaaatggg   Tcagaaaata   Cagattggtt   Ttcttgtcag   Taaaagtaat   2040     Ctgccatatt   Tttagcttga   Attactaata   Atttcactta   Tatgcatatt   Gtaatcactc   2100     Tgtgttacat   Acatttctcc   Atttagtttt   Taagattttt   Ttaagaagga   Acctaaaata   2160     Aagagcaaag   Atcaagcttc   Tttaatatgt   Ccaatttcag   Atatgaagta   Ggcatcctat   2220     Attatgtttt   Atcaggaata   Atacaattta   Actaaaagat   Attgttaata   Acagatactc   2280     Agactctaaa   Gtaatttaca   Tagcttttga   Acgtatgttt   Tcaaagaact   Ttagcatc   2340     Ccatactgtg   Tttagtttat   Aggtttagac   Ctctccccct   Ctattgagct   Cttaacactt   2400     Ttaaaatgga   Aaacaaatag   Taaagcagtt   Gctaaaaatg   Gcagttggag   Tagcttaaga   2460     Gtttgaattg   Tttgtttaag   Gactgaaacc   Aaatataaaa   Acttttaagg   Ggattttttt   2520     Tcatcattca   Acaaggaact   Gaaaattaca   Aggcttattt   Gcaatcttaa   Tttattactc   2580     Aatctgtttc   Ctcccacgtc   Tctaaatggg   Aacgcataac   Tttaatttta   Aaggacatat   2640     Tcccataggg   Aaatatagat   Atcactgtaa   Aacttacgac   Tttgaattaa   Gtaaaaagat   2700     Tgtggccatc   Actggctttt   Gagctgcaga   Agcagaagac   Atgtacctgc   Ccttcggggg   2760     Tattagggac   Ccgactaaac   Acacttattc   Ttctctctga   Ttgctggacc   Attccccaac   2820     Tatttggagc   Tccacaaagt   Atcaggactt   Catcaagagc   Tcagtgaagg   Gtgagatctc   2880     Aaagataaat   Atagaggact   Cattccaaat   Atagaaccag   Ttaagtttgc   Atgctccctt   2940     Ctgttgaaga   Aatatcaagg   Ggtttcctgt   Cttggcacta   Cttagcagca   Gctgcggcta   3000     Tgtatccact   Tgacatctgg   Tgaaattgta   Gtttttgatg   Gaggaacatt   Taaagttgac   3060     Aactgtcatt   Gaaacaactg   Gtatatagtt   Ttcaaagaca   Agctagaaac   Cagtaataga   3120     Ctaagtactt   Caattttgtt   Aaaagaaact   Gggtaaaggg   Ttcaagttat   Ataagatagg   3180     Gaagtctggt   Tttccaggta   Aaggttctct   Ctctttttct   Gttggagatg   Tcattcatca   3240     Acataacgaa   Gcctaaattt   Aaaagactaa   Gacaaaatat   Ttacaaatca   Cataaaagtg   3300     Aggaaacagc   Aaaattagta   Gtcattagga   Gaaagccagg   Gaagacagga   Cattcatcac   3360     Atcctttcct   Catctgcttt   Cctcactgag   Tctctgagtg   Ctcattaaat   Gctttcaata   3420     Cagtgtaatt   Aagtgtgtga   Acatggttgt   Catgctcctc   Caggaatctt   Gaaaccagga   3480     Atgccaggta   Tataacagcg   Ggttacaaaa   Gaaaacacgg   Attcctaaat   Cagtgtttta   3540     Ctgtcagtgc   Agtgttaaat   Gtcaatgcaa   Cacttaagtt   Gcattgacat   Tcatgtgttg   3600     Atcggattgt   Acaatgtgac   Gtgtgagatt   Tctcgggacc   Gtcgaagctc   Agacaactcc   3660     Agggctgcaa   Tttactcgtc   Tggctgccct   Cgaaccaggc   Tcccttggcg   Cgtggggctc   3720     Tcccggcgct   Tggtcccgac   Ccgcgccgca   Gtcaggatac   Cacggcaatc   Tggggtcgct   3780     Ttgtaaggag   Ctccgacctc   Cgggcagtgc   Agggatactc   Gacggcgcgc   Gatgtcccgg   3840     Cggctccgcg   Agcctggcgc   Gctgagagcc   Ccagcagtcc   Gagtcctcga   Gctcgggcgt   3900     Cttcgcgccg   Ccgccccgct   Cagtgcgccc   Aggcaccgcg   Gccgtgacgt   Cacgcccggg   3960     Actggccgtt   Gcagcaagac   Ggccgcgttc   Cggttccggt   Aggttgcccg   Ggagacgcgg   4020     Gtacacagag   Aagcggctcc   Cgtcggaggc   Cgagtcgtcg   Ccacgatcgc   Cccctgtgtg   4080     Gactcgcagg   Ccgagcggct   Tccccgcaga   Gctcgaggag   Ggcagacggc   Ggcgggggcg   4140     Ccatgagtca   Gaggcaggtg   Ctgcaaggta   Gggccgaggc   Gggcaggtgc   Cctaactagc   4200     Tggcgccgag   Gagacccggg   Tgcggtgggc   Tccaccgact   Ctctctcccg   Cagtgttcga   4260     Gcaataccag   Aaggccagga   Cccagttcgt   Gcagatggtg   Gcggagctgg   Cgactagacc   4320     Ccaaaacatc   Gagacgctgc   Agaacgggg   Tgagcccgga   Gcccgaaccc   Ccgtcgcccc   4380     Ccgcgcactg   Agtccccgac   Gcctccgccc   Cgctgccctg   Cccgtggagc   Tcttggggag   4440     Ccgcagtgtg   Gggaccggag   Ttcgcaaaag   Catccattct   Tttcagcggg   Tctttggggg   4500     Tcaggccgag   Agggtgaagc   Ttccagatgg   Ttgtgggagg   Tgcgcgttgt   Ccctgtttcc   4560     Atcttcattg   Cacacaggca   Agtgtcaggt   Tgaaagtcga   Ggccctagga   Attgcctgga   4620     Gtcattttac   Gtgaatggga   Ctctacccta   Atgagaccca   Ttttatccaa   Gtgccatttt   4680     Gcatgccacc   Ctgcctttga   Tcaccttcga   Cttcctcaca   Gcaaagcaat   Tccagtggtt   4740     Tagacgtgat   Ttctcgtctt   Gctttagtga   Aaggggaatg   Atatgcttga   Atcttttcca   4800     Agaaattcca   Agtaggtaga   Gaccagactt   Tgcgaaatcc   Tttaggcgcg   Ttccttctac   4860     Tcctcagtcc   Ggactcttgc   Agatgtgaga   Gggggagaga   Gggggagagg   Gagggagaga   4920     Gatcttctta   Tctcataaca   Taaactgata   Agagaaaat   Gttcttcttc   Ttcttcttct   4980     Tcttcttctt   Cttcttcttc   Ttcttcttct   Tcttcttctt   Cttcttcttt   Cttcttcttc   5040     Ttcctcttct   Tcttcttctt   Ttcttctttc   Ttctttcttc   Ttcttttttt   Ttggatgatt   5100     Ctaccaccat   Ctgaactgta   Aggtagcatt   Ttatcactac   Tgtgtcatga   Gaaatcttca   5160     Gtttatagga   Tgtgatcttt   Aaaactaaca   Cataatttaa   Acaattaaca   Tgttgacagc   5220     Aagaatactt   Aagtgtaatg   Attactctgg   Gtttctttga   Ggggaattac   Tactgcacct   5280     Atgtgatact   Tcgttttgtc   Actaggattt   Ttggcattta   Ttccttgtgt   Gtttttattg   5340     Gggggcatgt   Atttacaata   Aagtatattt   Tataatcttc   Taaacgcatt   Ttagtttgaa   5400     Ataattgtag   Attcacaact   Gtaagggata   Atacagagag   Atcccgtgta   Cccttttctc   5460     Agtttcccca   Atggtaacat   Ttttcaaaac   Tgtagtgcaa   Tatcacaagg   Aggacattga   5520     Cattgataaa   Aattcgttga   Tcttatatag   Gtttcctcct   Tttaattgtt   Cgtgtgtgtg   5580     Tgtgttttgt   Cctatagaat   Tttattccgt   Gcgtatccac   Caccagcaca   Gtcaagatac   5640     Agaacacttt   Cattgtcaca   Agtagcctct   Ctcttgccct   Tttatagcca   Cacacacctc   5700     Ctgctatccc   Taaccctgga   Caaccactaa   Tctcttctcc   Atttctaaaa   Ttttgtcatt   5760     Tcagaattga   Taatcctttg   Ttctatagtt   Gttttatatg   Ggttgatttt   Ctgtattctg   5820     Tgtgtgtgta   Tgcacccgta   Ctcctccaag   Tacccagaac   Aatactgggc   Acacagtatt   5880     Tcatatacac   Agactaacac   Agactaaggt   Attagaacat   Gttacatttt   Gaagagtgtat   5940     Ttaaaagtaa   Ttttaaagtg   Taaactttta   Aagttttttc   Tctcagtccc   Tctcaatgac   6000     Ctttgtgaat   Ggacatttac   Tacttaacaa   Agatttagtt   Tctggacaat   Atgaatatag   6060     Ccaaactaaa   Acttttaaaa   Tgggaaaata   Attgatatta   Ttttcaaatt   Tatatactga   6120     Gatgttaaag   Tatacataac   Ttttaagata   Cggagtatca   Tgttttagtg   Agtagtggca   6180     Ggttagctcc   Tcccataaga   Gtgcaatgta   Gacttcacaa   Tggaacttaa   Tccaaattga   6240     Ctgtataagt   Ggcttagata   Taagattcta   Cacttatggt   Ctggcttagg   Aaagatgaat   6300     Acgaaaggaa   Tataacttta   Tgttttgaaa   Ttctctgcac   Ttgactaata   Tctgggtagc   6360     Atgctaaaat   Gtttcttttc   Ctgagggact   Tatttttaac   Aaatttcatg   Tttacgagat   6420     Tcaattcaag   Cattccttta   Gcaattttaa   Atacagacat   Aatgaatatt   Caatgtattt   6480     Attcttttga   Ttaaaaaaga   Acctgtaaac   Tttgttatga   Aaacttttct   Ttctttcttt   6540     Gagacagagt   Cttgctctgt   Tgccaggcta   Gagtgcagtg   Gcatgatctc   Ggctcactac   6600     Aacctccgcc   Tcccaggttc   Aagcgattct   Cctgcctcag   Cctcctgagt   Agctgagact   6660     Acaggtgtgc   Gccaccatgc   Ccaggtaatt   Tttgtacttt   Tagtagagac   Ggggttccag   6720     Catgttggcc   Agtagggtct   Cgatcacttg   Accttgtgat   Ccaccccccct   Tggcctccca   6780     Aagcactggg   Attgcgcccg   Gccagttttc   Tttcttaata   Gtcagtttac   Ttaaccattc   6840     Aaatgatttg   Ttcttttaaa   Aaattacaat   Tttaaaaaag   Ggctttagaa   Tgagcctcag   6900     Tatgtgtaaa   Tcaattatac   Attatggtca   Aacttttttt   Cagtcaaatg   Ccttcatttg   6960     Gtagcttcag   Ataccaatgc   Atattactcc   Tgactttgac   Atactgtcta   Catacctgga   7020     Agattttgtt   Tgttttctca   Tttttccctc   Caatatgcta   Agtaaatata   Tatcatggat   7080     Ccaagataat   Gtaaaaaata   Ttttccatat   Gggtatcatg   Atcaaaccag   Taattccctt   7140     Gttaagaatt   Tttgaattta   Ttctatgtga   Aaggaatatt   Aaaggtgaaa   Attgtcaatg   7200     Gagtttttat   Ttcattttaa   Gtctccaatc   Ttttttattg   Tgttttttat   Acactaataa   7260     Gagaatttgc   Tttattaaat   Atgtccaaag   Taattgccaa   Agcagacaaa   Gtatgttgca   7320     Agatcttttc   Ttcagagtta   Tttggaaaag   Atatagttg   Atttccttct   Tttttgtttt   7380     Cgagacaggg   Tttcactctg   Tcgcccagac   Tggagtgcag   Tggtgctatc   Tcagctcaat   7440     Gcaacctctg   Cctcccaggc   Tcaagtgatt   Ctcctgcctc   Agcctcctga   Gtagctggga   7500     Ttataggtgc   Gtaccacccac   Acctggctaa   Tttttgtttt   Gttttgtttt   Gtttttttaa   7560     Tagagaaggg   Ttttcaccat   Gtttagccag   Gctggtctcg   Aactcctgac   Ctcaaaggat   7620     Ccaccccccct   Cagcctccca   Aagtgctggg   Atataagggc   Tgagccgcca   Cgcctgggta   7680     Gtaagtttga   Tttctaaaca   Aaattattac   Tagaaagaac   Ggtgtacaaa   Gcatctataa   7740     Cctgtaggtg   Tttttttttt   Tcctcactga   Ggttttattc   Ctctaaatta   Aaagaactca   7800     Tatgaacaat   Taaaaagttt   Aatgtctgtt   Ataaaatttc   Tttatgtact   Ctcaaattct   7860     Atatgtttga   Accattacct   Cttgcagcta   Tttaaaaaca   Aattttgata   Cttcccgtct   7920     Gaataattag   Taacacatga   Ctgtaatagt   Agagataata   Cattgttact   Tctaccaatt   7980     Gtaaaatttc   Agcaattgga   8000       <210>   96   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   RAX     <400>   96   Tgtgtgtgtg   Tgtgtgtgtg   Tgtgtgtgtg   Tgtgtgtgtg   Tgtgtgtgtg   Tgttttacga   60     Cagagtcttg   Ctctgtctcc   Caggctggag   Tgcagtggca   Cgatctcggc   Tcactgcaac   120     Ctccatttcc   Ctggttcaag   Agattcttct   Gcctcagcct   Cccgagtagc   Tgggattacg   180     Gtgcccgcca   Ccatgcccgg   Ctaggcccac   Catgttttgt   Aacggtctgc   Agattagata   240     Aagacagcag   Gaaatgaaga   Tggtacagga   Aagaacacaa   Ctagaacctc   Attttaaaaa   300     Aatatctcta   Gagagactgc   Agaatccagc   Cactgttagg   Attggaaaaa   Acattttgca   360     Gacaactttg   Gacaggaaga   Tattcttgta   Tacaattcat   Tcagaatcca   Ctaacataaa   420     Cacacacact   Tatactaagc   Acagagcaga   Ggaaagctgc   Ttctcaaatg   Agctgtcaca   480     Ttttaggtgt   Ctgtggtgaa   Gtaatgaggg   Agcagagatc   Ttagagacct   Agtgctccag   540     Tgaagtttgt   Tgacagtact   Ctgtttaagg   Tcccaggaac   Aagcaatgtc   Acagtcacga   600     Ctgggccaca   Gatctcctga   Ctcccaggca   Aaggagctgc   Cactgcacct   Gccattaaaa   660     Agccgacggc   Tcagggtgct   Ggggaaccct   Gcagtttccg   Tgtccgccag   Ggctggggga   720     Ggtgtggtca   Agtagctaga   Tgatttaatc   Cagtttacca   Aaggggttt   Atagtgagca   780     Attatagcgt   Ggtaaaggca   Tatatcacta   Atgagtcatt   Aactctgccc   Actattgtac   840     Agttaacaag   Cggaggccag   Attattagag   Ctggtcccca   Ataaaaggga   Cgacaaggtc   900     Acagagagca   Ccatccgcct   Ccacaagggt   Cgggtgcgtc   Cgtctggcgc   Tgcggggtct   960     Cgcctttacc   Aggagggcaa   Gaaggcacca   Agggggagtg   Cggagctctg   Gctacctgag   1020     Cgaagaggaa   Gtgcagctgt   Taattacttt   Aattgtattt   Tgtaataaat   Taatttttaa   1080     Ttttatcttc   Cctgacagtc   Tttccctgcc   Cacctcctgg   Aggcttggat   Tccattcatg   1140     Taataagatt   Ctgctggtga   Aaaggagctc   Ttggaatgta   Ggctggagaa   Gcggactggg   1200     Caaggctggg   Agtggggctg   Ggagcctggg   Gtgaggggcg   Gagctggatg   Ggatggatga   1260     Tggggacagc   Atctcatcaa   Atgctgaagc   Cgccaaggct   Ctcgggtccg   Cacccagggt   1320     Gccctcaccg   Tacgccgacc   Gtgtggggaa   Cacgctctct   Ggaagctgag   Ttgggggtcc   1380     Tggtctctct   Tgccgccccc   Tgcccccagc   Ttcctgcgcg   Tgggctccag   Cggtctccgc   1440     Aaagactttc   Agctagcctg   Tgaatttgga   Ctagagaggg   Agcaattggc   Attccctcta   1500     Ccgtcaccag   Attctagatt   Aactggggcg   Gggtggggaa   Caggcaggga   Ttgtctccac   1560     Tagtttgaca   Attcccattc   Cccaaacact   Gaatatgtat   Ttagggtaaa   Taaatttagc   1620     Agggtggtcc   Cagtttagtt   Ggtgacctct   Ggtcaaagcc   Cgcccctctt   Gggggttctc   1680     Ttccagtccc   Tccaccccat   Cccaccctga   Ccaggccgga   Tcaccctcct   Gagcagcgca   1740     Ggtgggggct   Cggaccggca   Ggggacagaa   Ccgtgttcgg   Aactaggaaa   Tccactaggg   1800     Atacacagcc   Tggaccggtc   Cagggccgca   Gtgcctaacc   Ccaggacacc   Gagcgagggc   1860     Gcctccgcgg   Tcctacggga   Acctcaggac   Actgagcgag   Ggcgcctccg   Ccatcctaca   1920     Gctgttctct   Taacgtcgag   Cctctggagc   Ccagcaatcc   Agagaggccg   Agccctcagt   1980     Cccctgcgtc   Cgtgcaggaa   Agaaattggg   Ctgcgagcat   Cgccaacaga   Agccgggagc   2040     Cgtggcgcgc   Atttaggaca   Cgccgccctc   Gcgcgcagag   Actgctccag   Aaagggaaaa   2100     Acgcaaaact   Taaaacgcgg   Tggctcacgc   Ctgtaatccc   Aacactttgg   Gagttcgagg   2160     Cgggagggtc   Gctgaaggtc   Agaagttgga   Ggccagcctg   Gcacacatag   Tgagaccctc   2220     Gtctctacaa   Aaaaagtaaa   Aacaaaaaac   Attagccggg   Cttggtggcg   Cacgcctgtg   2280     Gtcccagcta   Ctcgagaggc   Tgaagcagaa   Gcatcgtttg   Aggctgagag   Gtcaaggctg   2340     Cagtgagcta   Tgattgcgcc   Actgcactcc   Agcctcagcg   Cgagagcgac   Accctgtctc   2400     Taacaaaaca   Aaacaaaaac   Tgccgtgggg   Ctggctgatg   Gtggccacgg   Ggtcgcgggg   2460     Gaggtccgct   Cccggcaggc   Tccagctctc   Tgggtcagcg   Gaggtacccc   Gaggctcaaa   2520     Gagcggtcag   Ctccccacct   Ccccaaaagt   Gcctgactcc   Gcccttctct   Cggcgcggtc   2580     Caattcgcgg   Cgtccttccc   Ctccccgcct   Tcgctatctg   Agagccccgc   Ccaggccccg   2640     Ccacaacctgg   Ttcgcaagag   Cagaagagga   Tcccggtcta   Cagacccgct   Tgctttcctc   2700     Ctagggcggg   Tcagagcaga   Cgtcgtcggg   Gtttgggaag   Gaagcatctc   Cagacctctt   2760     Gaattgactg   Aagccaatag   Aggcttgccc   Taggtctgtg   Cttggagcag   Cacggtgcct   2820     Tttcttctgg   Aacctcgtaa   Gacccatgtg   Gttcttgttt   Tccttctgtg   Ggcactggta   2880     Gcatcacctg   Agccaaattt   Gcagcctcat   Tagagaagat   Tcaagaacca   Ttgcatgtga   2940     Ttcttgggaa   Agtgatgcag   Gcttccctcg   Gggtccctga   Aagcctcatg   Cccgtcctag   3000     Accgagccaa   Cagtctagtt   Ttggaagctt   Gtgactcaac   Ttcggccggc   Gcctctctgc   3060     Aaagcgtttt   Ctctagccat   Gggcttgagc   Agaggggccc   Caagtgtttc   Agggccatcg   3120     Gggttttaat   Gctctttatc   Acaagctgct   Cacctccagc   Cagagttaag   Tactggattc   3180     Ccgtcccatc   Tgcaccccta   Ctcctagagc   Tggcagtgaa   Tctcccaccc   Tcagagctgc   3240     Cctgcggggc   Ttggggacgg   Gggaaccctg   Gggcagatga   Tgtgtgaaga   Tctctccagg   3300     Aggctcagga   Aagcacagct   Agtgcccaac   Gctcaggatc   Tcagttccca   Atatggccta   3360     Atgagctgtc   Gtagaattga   Tataaggagc   Acttatcagc   Aatgttttcc   Caacacgcac   3420     Tatgatggac   Acttttggtt   Atttcagccc   Cagcacttag   Aaacaatgta   Aactgggaca   3480     Acctctccat   Gcctcagtct   Cctcatttat   Aaaatggggc   Taattgtatc   Ttcctggtag   3540     Gattgtggtg   Aggcttaact   Gagccactag   Atggaaacct   Ctcagaagag   Tgctggcaca   3600     Tagtaagcct   Tcaataatta   Ttagctattt   Atattttcgt   Gatcattttc   Caagggcttg   3660     Tctctgaaat   Gatgcctgga   Gagatggttt   Agaagaaaat   Ctattctcat   Ctgaaactaa   3720     Acagtagaag   Aggaagggga   Agtagcagaa   Aaactcataa   Ggaaagaatt   Gaaaaacagc   3780     Acagaggaga   Gagaatggat   Aatcttggca   Atgatctaag   Ggaagtgaag   Aagatgctga   3840     Cggtggcatg   Ctcaaggtca   Caggtgccca   Agactgcggt   Aagaaggagg   Acagggcacg   3900     Tgtggtactc   Acttggagcc   Catgaagttg   Gaagttctgt   Aaataaatca   Tccctaggga   3960     Atgaaagaat   Gaaacaaatg   Ataggccaaa   Cacacattca   Ttctggtttt   Gttttgtttt   4020     Gttttcttgc   Taaaaggtga   Taacacacgg   Gctgctccat   Cctcctcccc   Caaggagaca   4080     Tccttgtgag   Gaaaagtgca   Gatattactc   Cctacctctt   Gggggggaat   Aatttattca   4140     Gtacattttt   Actgatcagc   Ctactgtgtg   Caaggcacca   Tctggaggtc   Taggggtaca   4200     Cagccctggt   Tatgcaatag   Cctcttagac   Ccgcagagaa   Aggactggaa   Actatgatga   4260     Ggcttcccat   Attcccagct   Ccagggtggt   Catccttttc   Ccaagtcggt   Ttcaggaacc   4320     Ggagaacagc   Cagggaattt   Cggggaaatg   Gggacgatga   Ttacaatcca   Tattgcgtca   4380     Tgccagggtc   Ttggtacttt   Ccacaaagcc   Tttacaggtg   Atcttattcc   Atctttccca   4440     Ccttccagag   Agacagagt   Tatttagacg   Aggaaagggg   Actgggagct   Tcactaattt   4500     Gctcaggacc   Gacagacagt   Agccagttga   Tgctaattaa   Ggctctgggg   Gcatcatcct   4560     Gaaagcacgc   Ttagggacgg   Gggttgtggg   Gtggacgccc   Cccccccccc   Cgtgccagga   4620     Cctgttggcg   Ggcatccagg   Ttctgctggc   Ggtcgcccag   Cttccagtgt   Caacggtgga   4680     Tatcgagcac   Gctcaggcgg   Gagtccggga   Ctctccttct   Tcagagagtc   Tcaggagatt   4740     Gtgaagcggg   Ctgagatttc   Gagattcctt   Cctcgcccta   Gaggcggcgc   Caaagaactg   4800     Cagatactgt   Ccagggcacg   Cccgcaagaa   Ctagctctcg   Gggcggtggc   Gtagggcgct   4860     Ccaggacact   Ctccgagcgc   Ggcacctcac   Cagacgcgcc   Ttttaccgaa   Ctctgggttg   4920     Gcgagtgtgg   Agcgagttgg   Ggaggttaga   Gagtctcgcg   Gctccgaaaa   Ggaaaagcat   4980     Ctctttgcct   Cagttcttgt   Accgctggtg   Atcaaccttg   Ggtgttaggg   Actggcaccg   5040     Aaccggagat   Ctgcttggtg   Aactgagagg   Agtccttagg   Agagcgggga   Cgccaggggc   5100     Cgggggacac   Ttcgctctcg   Ccctagggaa   Ggtggtcttg   Acgctttcta   Ttgaagtcaa   5160     Acttgaaaat   Atcagctgcc   Gctggactat   Ggggctagcg   Ggggaactgg   Gagcgcgcta   5220     Gcatctgagc   Cttagcccca   Tccactccgg   Accccaagcg   Cgcacgccgg   Ctccagggaa   5280     Gggcgcctct   Ggtctaggcc   Gccgaagcgt   Tcggaatggg   Gacgattctc   Tgctgcagcg   5340     Aagtgtccct   Gaaattttca   Caaggaaacc   Ctgagcttct   Tctcagtcct   Cctctttccc   5400     Tgacccaccc   Tgtccgtcaa   Cgcaccctcc   Tcccgtaccc   Caatattcac   Tcctctcccc   5460     Aagtcctgag   Cgtgcttaaa   Cagagtcgaa   Acaaaacaag   Catgtcttta   Attctcctct   5520     Caaatagttt   Gaaactactt   Atacaaaagt   Ttctcaaact   Ctatttttcc   Gcctcccctg   5580     Cttccctgtt   Atggttatct   Gggggtctcc   Aagcctcctg   Ggaatggcca   Agtttaggag   5640     Cttcagcctg   Tttgggcctg   Gaggctccag   Cgcctgcggt   Gatgggagcg   Gcgtggccag   5700     Cggggcccgg   Cagcctgttg   Ccctccagct   Gcagggctga   Ggtccgcgaa   Gtgcgttgag   5760     Gcggccagag   Ggcctctcct   Caggcctgaa   Agtcgccctt   Ctccccgtgc   Atcgggagca   5820     Ggcgcgtggc   Cctgaactat   Gcttggcggg   Tggctgcagg   Cgacagggaa   Agaggggccg   5880     Agctggggag   Gggggttgtc   Cctgggagag   Agtaggcggg   Tacggtgcgg   Tcggcccggg   5940     Gtcggatccc   Aagacgttcc   Ccagtgcccc   Tagagggcct   Gccacggctt   Cccgatggcc   6000     Tggatgtgct   Cctgtgcttt   Cagacgcagc   Gccgcgatgc   Tgctgttgcg   Cgggtccgcc   6060     Tcgtccagcg   Ggaacttgtc   Cccgaagccg   Ggcccgcacg   Ggtaggaggg   Cggcggcggc   6120     Gcgagaggtt   Gcaggccggg   Gcccaacggc   Ggggagttca   Ggaagggcgg   Aggcggcggc   6180     Ggtggcgtgt   Agctggcagg   Caggctctgc   Gccggcggcc   Cgaagcccgg   Caggctctgc   6240     Agcgccgtgg   Cgcccccgcc   Cggcagcggc   Ggcccgagcc   Aggactccag   Cggcagcgcg   6300     Cccccagccg   Gcccgccacc   Gctgcccggg   Cccgccccga   Ggggcgacag   Cgtcgcggag   6360     Ggcggggagc   Ggctgaagga   Gaggaggggc   Gagtcctgca   Gcttcatgga   Ggacacttcc   6420     Agcttctcct   Gccgccgcca   Cttagcccgt   Cggttctgga   Accacacctg   Caggagagag   6480     Cacaggggcc   Gtcgggcagc   Agcggaggct   Gcggccgcgt   Ccccaaccct   Gaggcggttc   6540     Agctcggcgg   Gctccactcc   Gtccccctca   Aataaaacta   Ggggcgcaac   Tgttatgcat   6600     Gtgccgagag   Aggcccggat   Cttccttcct   Tccacccact   Cctactcctc   Ccaccccgcg   6660     Ttctcttttc   Ttttccatcc   Cctttctctc   Tctctctctc   Tctctttttt   Tttttttttt   6720     Ggcctcttct   Ctccattatc   Gcctcttctg   Agtctctttg   Tcccatccta   Gtcctccgtg   6780     Gcgtcccacc   Cttttctctg   Tttatccata   Gctgtggttg   Tatctgtttc   Caactcctag   6840     Tgcgtagcag   Aagctcagaa   Aaaaaaagtg   Aatttaactc   Cgcaatcgaa   Tcgtagaact   6900     Ttgaaacgag   Atctcaccaa   Ttttctgtga   Ccttctggtt   Ggcagcccct   Cctaacagtt   6960     Tagacttgct   Tgttctctgt   Atggtacaga   Tctaagttgc   Tgtattttgg   Tctcagactt   7020     Tctctgcttt   Acctaccctt   Tgtctctaaa   Tacaggtata   Aataaatatt   Gttaagtaga   7080     Gtaattggca   Agaatgggcg   Ttaaaattca   Gctcttttca   Cggattactg   Gttatgataa   7140     Ctagatagga   Gcaagtgggg   Tttattttgc   Ccacaaccata   Tttgaattgc   Tgctttaata   7200     Tttttatttt   Tatttaatta   Atgtctgctt   Actatttctg   Ctgtttgtta   Ttactttcaa   7260     Ggagtacaat   Cattccagtc   Tattatatct   Acttttacat   Tacaaagtta   Attttgacat   7320     Taccctaaga   Ccttagctca   Atgacaaggt   Tttttgcttc   Ttcttcttta   Tctgtacgaa   7380     Gtccttgcca   Agagtaacgt   Cgggttcttc   Caatgaaact   Tcattactga   Tttgataaaa   7440     Gtgctggaat   Atgtgtaatt   Acatttttac   Taccagttcc   Accttcacag   Gcaagacaga   7500     Gaatccgttt   Agtagagaac   Acaaaagaat   Ttcagccaaa   Ctggtggctt   Tagtgctata   7560     Tttatgaagg   Gaaatgggga   Gattgttgca   Acctcagaag   Ggagaaagta   Gttttcagtc   7620     Aataagggca   Ggggaccccc   Gaggagagct   Gaaagaacag   Caatccagca   Cccaagcacc   7680     Gcagggcaag   Tgtgtgagag   Gctgcaatta   Gggagaaaaa   Gagaaacaac   Aaaagtgtaa   7740     Gtaccctgta   Ccatcctaga   Aaagattcat   Ctgcatatct   Aaggcctcaa   Gtctccctta   7800     Aatattagat   Acttgccaac   Agtagagaaa   Agaaacactg   Atttgggtga   Gggctcctgt   7860     Cccaccacct   Tctcggcttc   Cctgtctgtc   Ccactcaatt   Ccctaccaca   Tcagctgtag   7920     Ccttcagatc   Tagtgtccca   Ggttatagac   Tgaaggattg   Aggtcggtta   Ttgcaatgct   7980     Ctactgctgc   Cctcggtgtg   8000       <210>   97   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   PRDM14     <400>   97   Acattttttt   Tttatctaat   Gagtggaagg   Atgatacaat   Tatcagatac   Agactcaggt   60     Agggaaaaga   Aatataagca   Gagaaactac   Ctcaggagat   Ctctaaattc   Tatctgtagc   120     Tccagaaaca   Gttctgtatt   Tccaacaata   Aaataagaaa   Actgttttcc   Actggtatcc   180     Attattccca   Gtaagtacac   Catactgcct   Gcagtcctca   Ttataatggt   Gtctcctaat   240     Taatagctgc   Agtgactggg   Agtagatatc   Aaataaagca   Atggttcttc   Aatattatgg   300     Atgtgatgtt   Aaacctcaga   Aatcaaatga   Tttttccaac   Attatacaat   Gaggaaatgg   360     Gggacaaata   Ctagtttgcc   Tgactccaaa   Atctgcattc   Tctatgttat   Accttatgct   420     Gcatctaaaa   Atgttcagcc   Agaatatagg   Tattagcgta   Gttttaatct   Cattctacat   480     Tctacgtggt   Gctttgtctt   Ctactttgac   Tgtcctagtc   Tactgttttt   Tttttttttt   540     Gagacagagt   Ttcgctcgtc   Gctcaggctg   Gagtgcaatg   Gcgtgatctc   Ggctcaccac   600     Aacccccacc   Tcctgggttc   Aagtgatttt   Cctgcctcag   Cctcccgagt   Agctgagatt   660     Acaggcacgg   Gccaccacgc   Cctgctaatt   Ttgtattttt   Agtagagacc   Gggtttctct   720     Gttggtcagg   Ctggtggtga   Actcccaacc   Tcaggtgatc   Tgctcacctc   Ggcctcccaa   780     Agtgctggga   Ttacaggcat   Gagccaccat   Gcctggctgt   Ctacagcttt   Tattattatt   840     Ttaaactggt   Ttaaattagc   Tttagaaata   Gattacatac   Attttatttt   Taaaaatttt   900     Aaatatattt   Ttaaaacagg   Gtcttatagt   Gttgcccaaa   Ctggtctcaa   Actcctaggt   960     Tcaagtgatc   Ctcctgcctc   Ggcctcccaa   Agtgctgggg   Tgacaggcat   Aagccactgc   1020     Acctggccaa   Taatatacat   Taaaaaaaat   Aaacataaaa   Gagcttcagg   Gtattactat   1080     Agagagatgt   Tatgttatga   Atgactgtat   Ttcccaaact   Aaaagttgaa   Tttagtaacc   1140     Ctatcaatat   Gaccaaaact   Ttgagtaaac   Aggtattaaa   Tgaaatggtc   Cccaaaattt   1200     Tctagttagt   Ataggatata   Tttaccgtta   Tacggtatta   Tttattgatt   Gttcaattac   1260     Tggcatgcat   Gcatttgaat   Gactgttaga   Aaatagcaaa   Aaaaataaaa   Taagaaaaaa   1320     Taaccctacc   Tccctttgct   Gctattctag   Gtcaaagaat   Gaagttgtta   Atttgaatta   1380     Ttcagtgagt   Gaaaaaactg   Ggatcacacc   Agtttgtgat   Gacttgtttt   Actatttgat   1440     Ttaaaaataa   Tgtttaaacc   Cataacagta   Gaagacatgt   Tcgagtaata   Cattttgaac   1500     Cagcagttaa   Ggaaaggctg   Cctaattaca   Caatgagccc   Ccacgtcttc   Gaaagaccat   1560     Tgttctgtct   Taattaacat   Gaagtaaatc   Agtcctaaaa   Caacagggca   Cattcccatt   1620     Aggataaatt   Actcagactt   Cagcaaggca   Gcaaataatt   Ccctagagta   Gaatctgtca   1680     Ctgcttttcc   Acctgcacta   Tatctctctc   Tcaaaggact   Gggctagagc   Tgggagcctc   1740     Cctctggaag   Gggcatctgt   Tccatattga   Atttgctcca   Tttgtggcca   Tgggtggagg   1800     Gtgcagcaga   Tccccaggca   Gtcagcagaa   Acacagctgg   Gatgggacag   Atcctcagca   1860     Gctgtggctg   Ccttcaaagc   Acttttatcc   Tgcttattct   Ggtctcaaat   Cttccacgtg   1920     Ggtatttcag   Tctgttattg   Cttaacttaa   Tatagggaag   Aatgggatgg   Gtagtctcca   1980     Gaaaaatgct   Attttctttt   Ttttttttat   Ttttttcttt   Ttttgagatg   Gagtctctgt   2040     Cacccaggct   Ggagtacagt   Ggcaccatct   Cggcttaccg   Caacctgtct   Cccgggttca   2100     Agcaattctc   Ctgcctcaag   Actcccgagt   Agctgggatt   Acaggtgtgt   Accataatgc   2160     Ctggctaatt   Tttgtatttt   Tagtagagat   Ggggttttgc   Catgttagcc   Aggctggtct   2220     Cgaactccta   Acctcaggtg   Atccacctgc   Ttcagcctcc   Caagtgctgg   Gattacaggc   2280     Atgagccact   Gcacctggcc   Cagaaaaaat   Gctatattct   Taacaggatc   Cataaaccag   2340     Gcatagaggc   Tagttaggag   Gctgggctct   Ggagctgggc   Agacctggct   Ttgcctctta   2400     Gaggcaaatc   Agcttgcccc   Acttctttca   Tctctctcag   Tctcagtttc   Ctcatctgta   2460     Aagtggtaaa   Ctcagtggta   Tcctctcaca   Gggttaatgc   Tcgatagttg   Ttggctatta   2520     Tgatccacgt   Atgagatgag   Tctgatgtct   Ctgtgcacgt   Tagagaaacc   Cattccccga   2580     Acacttgcat   Cagccgtagg   Ataccatgca   Gggcacattt   Ttcttttcag   Tgggcctcta   2640     Attaccagct   Aattagaaaa   Tccccccaaa   Atatcctgta   Tatttcatac   Tgtctattaa   2700     Tcaataatga   Aatcaggttt   Aaacctacag   Cagtatcagt   Atttttttag   Cctttcttca   2760     Tttggttatc   Atatttcttc   Cccaattgct   Taacatcaca   Gatggtgcga   Cagataactt   2820     Ctgtgccctc   Caagtaactt   Tggagctaaa   Cacattaact   Ggcatttgtc   Atgtggtggg   2880     Ggaggggtgg   Gaacaaagtg   Tttaaaatta   Atcaaaataa   Agatggaata   Ttaattcacg   2940     Accgaggagt   Tacaatacta   Atgaagctct   Gactcgaatg   Agttcttatt   Tatttatatt   3000     Tatttatttg   Agacagggtc   Tcgatctgtc   Acccaggctg   Tgcaccatca   Tggctcatgg   3060     Cagcctcgac   Ctcccaggct   Caactgatcc   Ttccgcctca   Gtgtcctgag   Taactgggac   3120     Tacaggcatg   Tgccacaata   Cctggctagt   Ttttctttct   Tttttttttt   Tttttttgga   3180     Gagatagggt   Ttcagcatgt   Tgcccaagct   Cgtctggaac   Tcctgggctg   Aaccaatctg   3240     Cccactttag   Cctcccaaag   Tgctgggatt   Acagccatga   Gccactgtgc   Ccagccaaat   3300     Ttttactttt   Atttaattta   Tttatgtata   Ttttagaagt   Gggaatcttg   Ctgtttccag   3360     Gctagagtgc   Actgactatt   Cacaggtgtg   Atcatagagc   Actacagcct   Caaactcctg   3420     Acctcaaggg   Atcctcctgc   Cttggcctcc   Caagcaactg   Ggactacagg   Tttgtgccac   3480     Cacgcttggc   Tttaaattaa   Tatttattta   Tttagtgggg   Tttttgtttg   Tttttgtttc   3540     Tgccaagtgc   Acagtatgat   Aagcgaattt   Ttagaggatt   Tgttctaggc   Ctgatgcagt   3600     Ggctcacacc   Tataatccca   Gcactttggg   Aggctgaggc   Cagaggatca   Gttgagccca   3660     Ggagtttgag   Accagcctgg   Gtaacatgtt   Gggatctgcc   Tctctgtata   Agaatctttt   3720     Ctataaagaa   Atgtaacacg   Tgatgaccgc   Attgtataat   Tgggggccca   Aggcaaatag   3780     Tagagaaaaa   Gctacctttt   Tctcagatca   Ttgcaacctc   Cgcctctggg   Ttcaagcaat   3840     Tcccctccca   Agtagctggt   Attacaggca   Tgtgccacca   Caccaggcta   Atttttgcat   3900     Ttttagtaga   Gacggggttt   Caccatgttg   Gccagcatgg   Tcttgaactc   Ctgacctcag   3960     Ctgatccgcc   Catctgggcc   Tcccaaagtg   Ttggaataac   Aggcgtgagc   Caccacacac   4020     Agccaactgc   Agggacttct   Ataacccata   Aaaggaaata   Gagagaatcc   Gaatctcttg   4080     Tttttacatt   Gtctccacac   Tcttgagggc   Tactcatttt   Ttttgttttg   Ttttgttttg   4140     Agacagggtc   Tggttctgtc   Acccaggttg   Aaaagcagtg   Gggcgatctc   Agctcacagc   4200     Aacctccgtc   Tcctgtgctc   Aaaccatcct   Gccacctcga   Cctcctgagt   Ggctggaacc   4260     Acaggcatgt   Gccaccaccc   Ccagctgatt   Tttgtatttt   Tttggtagag   Acaggatttc   4320     Accatgttgc   Ccaggctggt   Ctcgaactcc   Tggacttgag   Tgatccaccc   Acctctgcct   4380     Cccaaagtgc   Tgggattaca   Ggcgtgagtc   Attgtgcctg   Gcagggctag   Tagtcttcat   4440     Gaaacttcat   Gtgggagtag   Aatgtttctt   Gatctgagaa   Gattttccca   Cagatgctgc   4500     Atgagcagcc   Atcatcctcc   Ttgtgtgaac   Gccggacatg   Gctgtcatgg   Gcagcatggg   4560     Atgcaaaaga   Tttaccacag   Tacttgcatt   Tgaagggctt   Ctccccggag   Tgctgcctga   4620     Tgtgtgtgcg   Gagtatgctg   Gaggctgtga   Acctctgcag   Agaacagaaa   Tacagaacac   4680     Aagaaaaagt   Caacttccac   Gagctggaca   Accaattaaa   Ctaaggggta   Aatttcactg   4740     Ttgctcatcc   Ttatggacga   Accttgggtt   Ttaaggccat   Agagcactcc   Tggtcatcat   4800     Cagtagcctt   Aatccgaaag   Gactccactg   Atgtgtcctt   Ctggctagtt   Ttgagaagca   4860     Ctggatgtta   Gaacagtggt   Tcttcaatgg   Ctagattatc   Tggaggtcca   Gtttgtaaaa   4920     Aagcagattg   Caggctgggc   Gcagtggttc   Acacctgtaa   Tcccagcact   Ttgggaggcc   4980     Aaggcaggtg   Gatcacctga   Ggtcaggagt   Tcgagaccag   Cctggccaac   Atggtgaaac   5040     Cccatctcta   Ctaaaaatac   Aaaaattagt   Caggcatgct   Atcgtgcacc   Tttaatccca   5100     Gcttctcagg   Aggctgagat   Gggagaattt   Cttgaaccca   Ggaggcggag   Gttgcagtaa   5160     Gccgttattg   Caccactgta   Ctccagcctg   Ggtgacagag   Tgagactctg   Tctccaaaaa   5220     Aaaaaaaaaa   Aaaaaaaaaa   Aagcagactg   Ccaggctggg   Caacatagca   Atacctcacc   5280     Tctacaaaaa   Gtaaaaaaat   Tacctaggca   Tggtagcatg   Tacctgtggt   Cccagctatt   5340     Tggaaagctg   Aggtgggagg   Ataacttgag   Ccagaaggtc   Aaggctgcag   Tgagttatga   5400     Tggcaccact   Gcactccagc   Ctgggtaaca   Gagcaagacc   Ctctctttaa   Aaaaaaaaaa   5460     Aaaaaaaaaa   Gcagattacc   Aaccccaccc   Aagagagtgt   Gacccaataa   Atctgacatg   5520     Agacccagga   Gcctgcattt   Aaacaagcaa   Ttctgatgca   Tgtgggtcct   Agtagacac   5580     Ttcaagacaa   Acctcattac   Gagaagagaa   Gctaatatcg   Accagaagct   Aatatcggcc   5640     Agtgtctttg   Cataagcag   Tgccttactg   Gttttcttct   Tcttcttctt   Ctttttaatt   5700     Taaacttttt   Gagatggttt   Gtaggtttgt   Tttatttgtt   Tgtttgtttg   Tttgttttga   5760     Gacagaatct   Cactccatca   Cccaggttgg   Agtgcagtgg   Cacaatcttg   Gctcactgca   5820     Acctccacct   Cccaggttca   Agcgattcta   Gtgcctcagc   Ctcccaagta   Gctggaatta   5880     Caggtgcact   Atgatgccca   Gctaattttt   Ctatttttag   Tagagatggt   Gtttctccat   5940     Gtcggccagg   Ctggtttcaa   Actcctgacc   Tcaggttgat   Ccaccccact   Tggcctctca   6000     Aagtgctggg   Attacaggtg   Tgagccacca   Cgcccagctc   Agtggtgttt   Ttctatgccc   6060     Attattttca   Ttctattgac   Acacactttg   Gaggtattag   Ttgctctaat   Ctggtagact   6120     Caatgtttta   Ttccttttga   Gaggcttaga   Agtagctgta   Ggacaggctc   Tactcctttt   6180     Acggctttac   Tgtaaaaagc   Gtaaatgact   Cagtgactga   Aaacataatc   Tataccagtg   6240     Ctttccaaca   Ggacttgctg   Caataatggg   Aatattcatt   Acccacgctg   Tccatcttgg   6300     Aaatcaatgg   Ccacatggag   Ccattgagca   Cttaaaatgt   Ggctaatgca   Acctagggaa   6360     Cggaattttt   Caactttact   Tcgtctttac   Taattgaaat   Agccacatat   Gattaaccgc   6420     Gaactgcaca   Ttgggtagca   Tagagctatt   Ttggtgtaat   Atgtctaaag   Cgtggtcaac   6480     Ctattgtttc   Tattatagca   Acctctaacc   Acatgattca   Tctctgtttt   Tacaactctg   6540     Tattctgtgt   Aacatagact   Agatgccgct   Tctgcaatgc   Tcctatagaa   Aattacatca   6600     Gtagcatcct   Tcacagatta   Aagtagtaat   Aatagcagtt   Aacattccag   Tagtactttt   6660     Atgttatgcc   Aggcactgtt   Acaagagttt   Tatatacttt   Actgatgtta   Tccaacaact   6720     Tggtaaagac   Tattctcccc   Agttattaca   Tgtggaaact   Aacaggagtt   Catggacttg   6780     Ctcagggtgg   Cacagctagg   Taagcaccag   Aggcaggatt   Tgaaacttgg   Ccatgtttgt   6840     Gttcttaaat   Actatgaaat   Agtgattttt   Tttttttttt   Ttttttggag   Acggagtttc   6900     Actttgccac   Tcaggctgga   Gtgcagtggc   Acaatcttga   Ctcactgcaa   Cctctgcctc   6960     Tgggttcaag   Tgattctcct   Gcctcagcct   Cccaagtagc   Tgggattaca   Ggaacgtgcc   7020     Accatgccca   Gctaattttt   Gttattttag   Tagagatggg   Gtttcaccat   Gctggccagg   7080     Atggtctcga   Actccctatc   Tccaggcacc   Tgcccacctc   Agcctcccaa   Agtgctggga   7140     Ttacgggctt   Gagccaccac   Gcctccccac   Cccctccttt   Tttttttgag   Acagtgtctc   7200     Actctgtcac   Ccaggctgga   Gtgtgcagtg   Gtgcaatctt   Ggctcactgc   Aacctccact   7260     Tcctggactc   Aagcaattct   Ccaggctcag   Cctcccaagt   Agctgggact   Acaggcataa   7320     Gccaccgatg   Caggaaaat   Ttgattatag   Gtgtgagcca   Ccacactcag   Ctagtgcttt   7380     Taaatactat   Gtaataggtc   Atcaggtccc   Cataatattg   Gaatgtattt   Tattacatgt   7440     Actctaaatg   Ccagcttggc   Aataggaggt   Tggttatatt   Tgaccatctt   Tagcaaactt   7500     Gagcatattt   Aggggtggaa   Atgaggactg   Ggctgatatt   Tgactaacat   Ttaccaagaa   7560     Ctcattaagc   Caggctttgt   Ttcaagttct   Tatccataga   Cactcaagca   Gagctcagga   7620     Cacatccctt   Agtaagaggt   Tccatttacc   Ttagtacaat   Acacacactg   Gtatggtctg   7680     Tctccagagt   Ggactcgcat   Gtgtttgttt   Aggctggaag   Attgagagaa   Acatttccca   7740     Catgtagaac   Actaaggtga   Aaaagaaaaa   Tatagttgaa   Atcacacctt   Cctctaacaa   7800     Gtccatttca   Accttgcgtt   Tacctggggt   Tagagaagaa   Ctcttttcca   Atttttttct   7860     Tttttttttt   Tttgagacgg   Gatctcaatt   Tgttacccag   Actggactgc   Agtggcacaa   7920     Tcacggttca   Ctgcagcctg   Gaactcccag   Gctcaagcga   Tcctcccacc   Tcagcctcct   7980     Gagtaactgg   Gactacaggt   8000       <210>   98   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   HIST1H3E     <400>   98   Actttcttct   Tttcatgaaa   Tggcattgtg   Cttccacagt   Gatttctctt   Cccctttttt   60     Taaacaccag   Aattagcagt   Tgtagaggct   Gtccctcaaa   Aatatatgat   Cgaggggaaa   120     Atattcatat   Aacatttctt   Tttttgttgt   Tttgttttgt   Tttttttttt   Tcatttttgg   180     Gtcatgctct   Gttgcccaga   Ctgggttgca   Gtctcacaat   Tatgactcac   Tgcagcctca   240     Aattcctagc   Ctcaagcaat   Cctcctaact   Cagcctcctg   Ggtcactggc   Attatcggac   300     Tgagccactg   Tgcccggcta   Aaagaatttc   Aaatactgtc   Cacttactga   Tattttgcta   360     Tggaaaaatt   Caaacatcaa   Taattttgct   Agttgcccac   Ctcttcttgc   Gtcattgagt   420     Aatggcttaa   Caagccccct   Tagctctcta   Acacaactgt   Atagacatat   Agatgtagat   480     Ataaatatag   Atattgattt   Attgtaaata   Aagtccagat   Gctataactg   Ggttcataga   540     Aatatattga   Atgtactcat   Tgtttcaagg   Cctatgctgt   Caagatatgg   Taaagaatca   600     Agaaacagag   Aagagaaatg   Aagaatcctg   Gaacagtgct   Atctacaaag   Aataatgcaa   660     Gccacggcca   Gatgcggtgg   Ctcatgcttg   Taatcccagc   Actttgggag   Gccaaggcag   720     Gtggatcacc   Tgaggtcagg   Agttcaagat   Cagcctggcc   Aaaatggtga   Aactcccccc   780     Atctccacta   Aaaataccaa   Aactacctgg   Gtgtggtggc   Tggtgcctgt   Aatcccagct   840     Actcaggagg   Ctgaggcagg   Aaaatcgctg   Gaaccggaga   Ggcagaggtt   Gcagtaagct   900     Aagacggcag   Cactgcactg   Cagcctgggt   Gacagagcaa   Gactctgcct   Caaaaaaaaa   960     Ataaaaataa   Aaaagaataa   Tgcaagccac   Atatgtaatt   Ttgaattttc   Cagtaagcac   1020     Attttaaaaa   Ttaataagca   Ggtaaaagaa   Ttttaataat   Tattgtattt   Aaaacaaaat   1080     Acaaaataat   Tatttcaaaa   Tatagtcaat   Ataaaaacat   Tattaatgca   Atatttcaca   1140     Ttctttttta   Aatcttaagt   Cttctaaata   Tgagggacat   Cctattcaat   Ttgatattac   1200     Atttttgttg   Gaaataaatg   Gaatttcatt   Ttgatttcat   Aaatttcagt   Gctgaaaaat   1260     Aaaattcata   Tatctgattg   Tttaaaacat   Atctaacatt   Ttccaataac   Tgaagtatca   1320     Gcctttgaat   Taaaataatg   Aaaagtaaaa   Taaaaattca   Ggccgggcac   Agtggctcac   1380     Ggctataatc   Ccaggacttt   Gggaggccga   Ggtggatgga   Ttacttaagg   Tcaggaaatc   1440     Gagaccagcc   Tagccaacat   Gatgaaaccc   Cgtttctact   Aaaaatacct   Ccacccccacc   1500     Ccccccaaaa   Aaataagccg   Ggcatggtga   Caagcacctg   Taactacagc   Tactctggag   1560     Actgaggcag   Gagaatcgct   Taaactcggg   Aggtggagct   Aacagtgagc   Tgagatcacc   1620     Ccactgcact   Ccatcctgag   Tgacagagca   Agactccttc   Tcaaaaaaaa   Aagaaagtca   1680     Gtcctcagca   Gcaacaacca   Catttcaaat   Gctcagtagc   Cacaactggt   Ttctgactgt   1740     Tttatcacat   Aacacagatc   Ctatagggaaa   Ttgtgttcag   Gtatggaaat   Agtgatggaa   1800     Attactgatt   Aatacaagtg   Agctgctaag   Ttcttatgta   Atcatgtaaa   Ttttgcactg   1860     Acttctaaaa   Taaagcttta   Cacatattta   Gagatgagga   Tttagaaagg   Aactgaaggt   1920     Aggttccaat   Ggcaaaacac   Cggattgaca   Gatttaagaa   Cactggggag   Gaaatagaac   1980     Tatggggcat   Aaagatggaa   Tttccttaat   Ggttctcact   Gactgtgacc   Taaagtttat   2040     Cttttgattt   Tggaaacatt   Ttttagatgt   Agatattaac   Attctaataa   Tagaaatgaa   2100     Aaaactaaaa   Tgaaaatgag   Aaaacagaag   Ataatatcaa   Taaacaggtc   Ttgggcctca   2160     Gaagatgaga   Tgtagggagt   Gtggagagga   Aaagcacagg   Gggtgcatag   Ctctcattaa   2220     Caaacggccc   Agcccacaaa   Tacgtaatca   Tattatacaa   Aaggatttca   Gttcttccct   2280     Tgcttcctat   Gaaacaattt   Tgccaacata   Cctaaccgtt   Ttccgtgat   Ttaaagtgta   2340     Cagaattttc   Tttttctgaa   Aaggagagaa   Gcaagggact   Catatatatt   Tcagatgtga   2400     Gattgaaacg   Cacgacaatg   Tgtaatttca   Gtcaagactt   Gcccacgagt   Ctataagataa   2460     Ttcaaatttg   Caaaatagac   Actaacttga   Aaggtgcaat   Tgtatcaatc   Ctgtggttag   2520     Cagaattttg   Atgaatgccc   Taaaataggg   Caggtttaac   Gaaattcagg   Gaatgagcag   2580     Gaatgcacaa   Agcatccttt   Gtctcctctc   Cactccagct   Tgcagacatc   Cgcgggcatt   2640     Tgcgggcagt   Gataaatttg   Gtttagccgt   Ttccccccc   Tggaggacgg   Gggctccagc   2700     Atattcatga   Tgtcaatcgc   Cttggactac   Atgccagcgt   Cattgcgaac   Ctgctacact   2760     Ttacaaaata   Gctttccaat   Gagaaagaaa   Acctactggg   Aaagaaaaac   Aaaaagaaac   2820     Tagaccttgc   Aacgggcacg   Cacgcgcact   Atccctctct   Gaaatattta   Ttagacgctt   2880     Acacaaacgc   Gaacttgtaa   Atcaaaactc   Tgcctgaacc   Aaagtagcca   Atagattaaa   2940     Agtatgtaaa   Ttaggaattc   Ccaaactgct   Ctttttattg   Gctaggaaaa   Gaacacctta   3000     Cagggaatcc   Gataggttaa   Ttcacaatag   Tgttaggctg   Taatgtcatt   Ctttaagaat   3060     Cttttccagt   Aaacatttgt   Tactttttca   Aagtaattgg   Gagctgttga   Gtgtggaagc   3120     Gaaaaccaag   Ttaagaagc   Ctgttatttg   Ggtgagtcca   Gttcctataa   Aagttctgtt   3180     Ggatgtgtct   Taaattgttc   Ggtgcacctc   Agctctctcc   Cgcagggatc   Cggagaaact   3240     Gcgccattgt   Tgtcttacag   Agacaacacc   Ttctaacact   Ctcttcgccg   Ccatcttttt   3300     Caagatttta   Aattgaaaat   Actttttttg   Acggctcttg   Ccattatgtc   Tggacgtttt   3360     Aatttcaaca   Aaacgaaata   Atagtgttaa   Gttctttgag   Tcaaacccga   Tattacagag   3420     Gtagggattc   Caggatatta   Gaattttact   Ataacacaaa   Tgaaacacaa   Agttccttat   3480     Gcttaacagt   Gtatcttaga   Aaaccttgtt   Tgagtgaatt   Agccttgtac   Tctataatga   3540     Aacgaggaat   Cattgagaga   Tacttaggca   Acggatttta   Aatgagtgaa   Taaggaaggg   3600     Aaaaacttca   Ggaaaatgca   Gaaaaaagca   Gcggagattt   Tggaaaaaaa   Attctaaagc   3660     Actttctaac   Gcaaacacat   Tcgatttttt   Atagctaaac   Aggataacag   Atcagtctat   3720     Taagttaaat   Gatcaatgtc   Tttgcaggtc   Atggtctacg   Tgaaacatca   Aagaaacctg   3780     Taacggaaaa   Cgacttgttt   Gaaagagcca   Gttctctatc   Caaatttacc   Aatcagaatc   3840     Ttgcactgaa   Aaaataaacc   Aatcgtgaat   Ctctacggcc   Acttccggaa   Tttagcaacc   3900     Gatcactaac   Aggtagcgtc   Cacaatccaa   Tcagagtgat   Tctgttccta   Tatagagggg   3960     Caaaccaatc   Ttcctaactc   Atttactttg   Cagatgaact   Atggcgcgta   Ctaagcagac   4020     Ggctcgtaaa   Tccacaggcg   Gtaaagcacc   Gcgcaaacag   Ctggccacta   Aggcagctcg   4080     Caagagcgct   Ccggccacgg   Gcggcgtgaa   Gaagccccat   Cgctaccgcc   Ctggcaccgt   4140     Ggctctgcgc   Gagatccgtc   Gctaccagaa   Gtctaccgag   Cttctaatcc   Ggaagctgcc   4200     Gtttcagcgc   Ctggtgcgag   Aaatagctca   Ggacttcaag   Accgacctgc   Gcttccagag   4260     Ttccgcggtg   Atggcgctgc   Aggaggcctg   Cgaggcctac   Ttggtggggc   Ttttcgagga   4320     Caccaacctg   Tgcgctattc   Atgccaaacg   Cgtgaccatc   Atgcctaaag   Acatccagct   4380     Tgcccgccgc   Attcgtgggg   Agagggcgtg   Aattgttttg   Agtacaaacc   Ttaaatccaa   4440     Aggctcttct   Cagagccaac   Cactttgtcc   Gtgaaaaggg   Ctgtaatcct   Ttgagacgca   4500     Ttagaccact   Aaactgcact   Gatccaaata   Gacatttgaa   Atagtggcat   Tcagttccct   4560     Cgatgcttca   Tttaaatttc   Caaatttaag   Cgctccctca   Ggttttcgcc   Tagggctggg   4620     Cctccctacg   Ctgttctcca   Ttggtttagc   Tggctttgtt   Ttgctgttca   Ggccctctgc   4680     Tgctttcttg   Tacattgttc   Tcgttttcta   Aactcctggc   Cacttaattg   Taccctgctt   4740     Aacccatcct   Cttgttttct   Ggctcaacgc   Tctttcatgt   Ggtggcctgc   Attttaggtc   4800     Ttaactgcat   Aggctttcaa   Cgccttggtt   Ttgcctttcc   Ttgatgttta   Tttgaccttg   4860     Cccgaggggc   Cagcgctttt   Gatctgcatc   Aggctgcctt   Actccactag   Tgttttgaga   4920     Cccagctact   Tgccggcgac   Ggtcggtgcc   Ttgggtgcgg   Tcaacgttac   Tctctgtgcg   4980     Cctgatactg   Gtctaaggct   Aaggttatta   Gctggaacac   Ctagacccgt   Ggcactaaca   5040     Cacagctctt   Gcagacttga   Cagccttgca   Taggttctaa   Actgcaggag   Tcaaagcaac   5100     Gaaggtgcag   Atgggtgtgt   Ctcaaacctg   Agtgcgaaag   Gaaaatgcag   Aaatcatgag   5160     Ccttttcaac   Tttccagttg   Atatcttttg   Tttgcttttt   Tcttttctta   Tttatttatt   5220     Tatttattta   Tttatttatt   Tatttattta   Ttttgagacg   Gagtttcgcc   Cttgttgccc   5280     Aggctggagt   Gcattggcgc   Gatctcggct   Caccgcaacc   Tccgcctccc   Gggttcaagc   5340     Gattctcctg   Cctcagcctt   Ccgagtagct   Gggattacag   Gcatgagcca   Cctcgcccgg   5400     Ccttccggct   Gatatcttaa   Aagaactttt   Caactttagt   Aaataccctg   Tcttaatcaa   5460     Atctcattaa   Aagtacccca   Tatttatcaa   Caaaacatga   Aaatccttgg   Acggcttcaa   5520     Agttcttaca   Gaaaatattc   Tgcctttcct   Ttccatacaa   Aggcacagct   Tcgaaactgg   5580     Taggtgaagg   Gaaggaaaat   Aaggaattct   Gttacgaaat   Catacaggct   Gttatttgga   5640     Aatacagaag   Ggtgtatgta   Ctattaggga   Tactgcatgc   Tatttggaag   Aattttgttt   5700     Atttaaacat   Ttcagcaaat   Tcctcagttt   Tgatatgggg   Tgcagtattt   Ttaactcatt   5760     Gagaaatttc   Tactaacttt   Tttgaatgtg   Ctcttttccc   Actagttgca   Ctaaggaaag   5820     Aggttagtca   Tgtggtaaaa   Ttaatagtga   Caaagctgta   Aatagctctg   Caggccaagg   5880     Tagccatagt   Aagaagtcct   Ggagatttat   Ggaagaaatt   Tttgttcatg   Gaagcctgtc   5940     Agacatgaag   Atgtgggtct   Tgtgaattgg   Agattcagtg   Cgtgaggaaa   Acagcctaac   6000     Tatccataat   Taaggtaact   Actgtcagat   Atttgtaaca   Tagtgaacat   Cctattatgc   6060     Tagatagaag   Cattctctat   Ttgaatgttg   Tttcctgtat   Cctgtacttt   Ctttaagatt   6120     Ctagctcaac   Aagttttaac   Ctgtatttct   Cttacagcta   Ctggaattca   Gtacgtgagg   6180     Acttggactt   Ggtgggcaca   Gaatgcatct   Ttttatatca   Ttaaatccac   Cagaacatct   6240     Agcatggtca   Tttgcctaaa   Acaaagcctc   Tggaaattta   Gtcaagttga   Gatgtaaaat   6300     Aaaagattac   Tgaacagaat   Ttaacattga   Gtgcattcct   Atttacaaaa   Ataaaagatt   6360     Agataaagtt   Tatataattt   Taatatatag   Tttttctaaa   Taggaaaaat   Ccacacttat   6420     Tgagtggctg   Caatgggcca   Gaagtcatgc   Agtattttat   Gaagcctcca   Aaaatgtaag   6480     Ttcaatagtt   Atctattatc   Aaaaacaaat   Ttaaaaactg   Aaactaagaa   Aatttcagat   6540     Agtgctggag   Ccaaaacttt   Ccccactagg   Cattactgtt   Ttaataataac   Agcctcagca   6600     Gaatcctcat   Cagttactcc   Tgagggcttt   Atcacctgga   Agagctacta   Acatgtttaa   6660     Atttttcata   Cacaataaaa   Taaatggatg   Ttttaaaatt   Tacagggtct   Taggccaggc   6720     Agggtggctc   Atgcctgtaa   Tcccagcact   Ttgggaggcc   Aagccaggca   Gatcacctaa   6780     Aatcaggagt   Tcaagaccag   Cttggccaat   Atggataaac   Cccgtctcta   Ctaaaaaaat   6840     Acaaaaatta   Gccgggcatg   Gtggcacttg   Cctgtaatcc   Cagctacttg   Ggatgctgag   6900     Gcaaggagaa   Tcacttaaac   Ctaggaggca   Gaggctgcag   Tgaactgaga   Ctatgccact   6960     Ccactctagg   Ctgggtgaca   Aagcaacatt   Ccatcttaaa   Aaaataataa   Caccagcctg   7020     Gccaacatgg   Tgaaacacca   Tctctactaa   Aaatacaaaa   Attagctggg   Catggtggca   7080     Gacacctgta   Atcccagcta   Ctcaggaggc   Tgaggcagaa   Gaatctttga   Acctaggagg   7140     Cagagctggc   Agtgagctga   Gattgcacca   Ctgcactgta   Gcctgggtga   Cagggagaga   7200     Ctccatctca   Aataacaata   Ctaataataa   Gaaaatgaac   Tttacagggt   Cttatatgat   7260     Tgtgaagttc   Tattatatta   Taattagtac   Tgcaaattgc   Acagaaatgt   Aactgatgta   7320     Catacaggaa   Aatatgacat   Taacactgac   Aaattttagc   Ctttctgcat   Actattcaaa   7380     Tagtagcctt   Gatttaacca   Cacatacaca   Ggcaactttt   Ttcaaaggca   Tacactgaga   7440     Tagtagtaaa   Taataccaga   Tgtctttaaa   Ataaattgtg   Attttatttg   Gggaagatct   7500     Caaatctgac   Ccctgtaaga   Tcatactttc   Tatgtacttg   Ttggtacact   Atatagtata   7560     Tatccatttc   Acagttacat   Agttgcctgc   Aagtacttat   Aattaaaata   Aaacaagtat   7620     Gtaatctctg   Aataaccaat   Agcttcttca   Tattataaag   Ataatagcta   Aaactcaaga   7680     Caattcagaa   Atcccatttt   Attatttctc   Catactcacc   Cgactcgacc   Tgccaacagt   7740     Aaatattgat   Atgtaacatt   Ttggagtttg   Caaggcaacg   Gtgaaatttt   Ttttctttgt   7800     Ttttattttg   Tagttgcccc   Cactaaaaat   Tgtatatata   Taaaatggta   Tacttccgaa   7860     Gataaggtag   Tctgtaaatc   Aggccatgga   Aacaagggtc   Atgaaagggg   Cagagaaatt   7920     Tgttactctt   Cttttcccac   Acaggaaaac   Agaaaatgaa   Accactgaat   Ttgatgagta   7980     Tctgacaata   Atgtaaccca   8000       <210>   99   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ZIC1     <400>   99   Cccagagaga   Aaacctacct   Ccctccccaa   Tacacacaca   Ctgattttca   Aattcttagg   60     Gaactgagat   Gagtctgcca   Aagctttatt   Attttatttt   Cctttacttc   Ttcaagtctt   120     Agctaggatt   Ttggggcagc   Cgcattctcc   Ctgcagatgg   Ggggaggggg   Gaaaaaggac   180     Ctgatttttt   Tccctttggc   Cgcaattgca   Aaggcctttc   Tcgccccctc   Cttcaacatc   240     Tggttctttt   Tttctgggga   Cttcatacgc   Agcatatcaa   Atacacatc   Aatctagacc   300     Cactgggtgt   Ttgcctttac   Aatatttatt   Attgtggatc   Atttctctag   Ttcctcctac   360     Acctttttaa   Aaataagacg   Aacattgtgc   Aattactaac   Aaagaccatc   Accgaattga   420     Cgcaattcac   Cccagacagg   Ccgcctaggt   Caggtctctc   Cactttagag   Gcttcgactc   480     Agtgacgtca   Tcagctcgct   Ctacaccccg   Agcccaagca   Cctacaagac   Tacacaggca   540     Acgcctctac   Aggggttggg   Gtgggaaaaa   Ggcccgggga   Ggcctcacag   Cattgaatcc   600     Tgaagcctct   Ctggtgttcc   Tttgtctgta   Tttcttgttg   Ttttgaattc   Actccctact   660     Ccaagtatac   Aatgtatatt   Gagtctgtgg   Acgacaggca   Gatgtttatc   Tgtgtgccca   720     Ggccactcca   Taggggtgga   Agcgtctaac   Caccacccac   Ccaccccctg   Ctgaaaagac   780     Gatgaatctc   Ccttacctcc   Tttatagagg   Aggttggaaa   Aattaggact   Tgtgtgtttt   840     Ttgtttcaaa   Ggatacctag   Ggaaggggaa   Accataggaa   Ggcaaagagg   Aaagaaactg   900     Gagtcaagaa   Aacggctctg   Gaattccctt   Tgcccccttc   Cctgtatctg   Aacttctgag   960     Gttggaatta   Atgtggggga   Ggggagggtt   Agaggtgggg   Tgggagcggc   Ccagtcctcg   1020     Gagaaaatat   Ttcccattct   Gcgaagcatg   Cgggaaatct   Gtggctttac   Ttttgtcatc   1080     Tgcagttgac   Agtagtccac   Ataaattctc   Caactttttt   Ttccatctcc   Ctgtctcttt   1140     Tcgcccctaa   Ccctggtttt   Atgataccca   Gtcatgaagg   Cgcgtgtggg   Ggtgatggtg   1200     Ctgattgtga   Ctacagaata   Aataggggga   Ccatatttat   Cttctaaaat   Aatggacatt   1260     Atattagcgt   Attcagtgag   Ctccagcaac   Tattacaggt   Ggccggccgg   Ccttccttcc   1320     Ttccgccctc   Gccctcttca   Tgcctcagaa   Acgtggccta   Ctctgcattc   Ggtgtgtgcg   1380     Gaagcagcaa   Tcacagaggc   Agccctaata   Ccggaggcgg   Cggcggcagc   Agcagggcca   1440     Ggtggtagct   Cggggctgag   Gatcgcggcg   Ggggcagccg   Ctatagggcc   Caagccctga   1500     Cacacgtacc   Attcgctcaa   Gtcggcggta   Cgcgccgcca   Ccgccgccga   Ggaggccacc   1560     Tgggacttgt   Ggccgcagtc   Cgacgagggc   Gacacgaggg   Cagacggtgt   Agccgaatcg   1620     Tagccagagc   Tgggcggcgg   Cgagcgcccg   Tgcaccttca   Tgtgcttacg   Cagcgagctg   1680     Gggtgcgtgt   Agcacttgtc   Gcagccccgc   Accttgcacg   Tgtatggctt   Gtcgctagtg   1740     Tgcacgtgcg   Aatgcttctt   Acggtcgctg   Ctgttggcga   Agcgccgctc   Gcagccctcg   1800     Aactcgcatc   Tgaagggctt   Ctcgcctggc   Ggaggcaacg   Cagagacatt   Agtgcttgtg   1860     Ggtcgtgttc   Ccgtcaggtg   Cttgccaccc   Tcccccattc   Gtctctcatt   Ttctggaaaa   1920     Gaactacaaa   Atattttcag   Aaatcccttt   Ccacggcgcc   Tcaggtcgag   Cacccctttc   1980     Cctcgtgcag   Agagcgcccc   Cggtgccctc   Tcttgaacgc   Ctccatccct   Cccgccttcc   2040     Tcctctgggc   Tcatggggag   Ggtatggagg   Aggagggaca   Gtgactccat   Cttagtcgag   2100     Tttccatcct   Cgaaaatcct   Gatccactcg   Ggttgtttcc   Tccaaatttt   Ctccacttgg   2160     Aaccagaagc   Acctctgctc   Ggaaatacat   Taacggagga   Gctcacaata   Tagttaacgg   2220     Ggaagctcac   Atctgctcga   Tttaaagttg   Ctgtttcaga   Ctaacttctc   Tgccgctacc   2280     Ccgcccagcc   Gttcatcccc   Cccacccacc   Cccatcctgg   Cccaaattgt   Ttcctaaagt   2340     Aggttttgcg   Caaacgccaa   Agcgatgaaa   Taatttaagg   Atgcgcagcc   Gatgcacatt   2400     Gtgtgtgcat   Aaagtggatt   Cgtgctgcag   Ggagaggtat   Tctgagcaat   Gattcacttc   2460     Agaagagatt   Tttacaggaa   Tggagccccc   Tccctctttc   Cttctacccc   Ctgagggcaa   2520     Acatttagca   Gcattcttca   Aatcttgcct   Aaaccttccg   Ggatccctcc   Agatacgctc   2580     Gccagtaata   Atatttcatt   Acgctgctcc   Agaggcttcc   Tggagaccgt   Gctgtgggca   2640     Gctggccctc   Ccagtccgca   Ctgacttgcg   Atgtcgaccg   Gtctgcccag   Accaccccca   2700     Cctggctgtc   Gggcctctcg   Gtcctaagac   Gaggggttgg   Cgcggtaggg   Tccgcacagg   2760     Ccaaatggga   Tccgaggtgt   Ctaccgcaac   Cacgcccttg   Agcgctgcgg   Cttcgggaag   2820     Aaaacagctg   Ctgctgtcag   Gccaggcctg   Gctccgcagc   Ccggagggcc   Accaggcggc   2880     Tggcataggc   Cggggagggg   Ctgggatcgg   Tggctgcgat   Gccctgtaga   Gccgagggaa   2940     Ggcgcgagtg   Cacgttagag   Tgacaatatt   Ggccggaccg   Agccccaatc   Ggggagctca   3000     Cggccagctg   Aattcgctga   Cgtgtaggag   Aggaaaggac   Cccgagaacc   Cggaagccta   3060     Gattcctgcc   Ggagctgcaa   Gtgctgcgga   Aatgggggaa   Gaaggtttct   Gggcgcttta   3120     Aacaaatggc   Tgcctcccag   Cgctctgagt   Taagggaccg   Gctacctagc   Gtctagctga   3180     Ggaggaagac   Gcgcagctgg   Agaactgttg   Cctttgtagt   Tgcttctccc   Gccgcatcca   3240     Ggaaaaacag   Gcgctttggg   Gctggttaga   Acaaacaaag   Ccccaattcc   Cgagccctgt   3300     Tgaggctcgg   Acagagaggt   Ttgcgcacaa   Cctgcgcttc   Tgcgcaatca   Gcggctcctg   3360     Agcccgggtc   Tccggcacca   Cctggtcgct   Ggattcccac   Cctacaggag   Cacagctagt   3420     Acactgaaca   Gtctggaagg   Tgttggcacc   Tgccatttcg   Cgggacactg   Gcaccatttt   3480     Ataaaacagt   Gatagaaaga   Tgcggaataa   Atcagtgttc   Ctatttgccc   Ccatttttat   3540     Ctcctctgat   Tcctgccagc   Atttgcaaac   Ccaaaacttt   Cttccttctt   Ctctttcaaa   3600     Aaaaaaaaaa   Aaattacaaa   Aaacatacaa   Ttcagggcct   Gcaaaagaac   Caaggttatt   3660     Ttgagaaaac   Agaggtgaaa   Tggaattaga   Atttggtgcc   Cctccccaac   Aacccccacc   3720     Cccaacaaaa   Atcccgccaa   Acgcttatcc   Gatctcgtga   Gcgcctcact   Ggacattcac   3780     Gtaaaacaaa   Aacaattatt   Tcgctccaga   Cgaggagcag   Aggagaaaac   Agcagtgcac   3840     Tgagtgatac   Cggcagccgg   Gaagttcgca   Ggcccctagg   Aggccaggtg   Aggccgcgcc   3900     Ccagcttgct   Ccggagctgc   Aggaggcgcc   Ctggtctctg   Cgcttgacat   Cacccccgcc   3960     Ccccgccaac   Acccggcctc   Cagtccttcc   Ccctccctcc   Agctccctgc   Actgcgccct   4020     Gggtgggtgg   Gtgaatgtga   Agaggcggcg   Ttgggctagg   Cccctgcagc   Ccgctcggag   4080     Cgtcctaggc   Ccggggctgc   Gctgtgaaag   Acccagattc   Tcatcccaga   Ggcccagcag   4140     Tcctgaaagg   Cctcctctcc   Gaccctgagc   Cgggtccgcc   Gaacaaagtt   Cggaagctcg   4200     Ggctagctgg   Gccagcgcca   Ttttctcgca   Cttgtggctg   Gatctggttg   Tcccggcgac   4260     Tgcgccccgg   Cgcggtctct   Tttcctctac   Ctcggatccc   Cagcactgac   Tcgccctcag   4320     Acgccgggga   Aggtgtggtg   Agctcccggc   Cccggccgag   Gggtccctgg   Agaggagctg   4380     Ggtggcggtg   Gccaggccga   Gcgcggttgc   Tggcccgcgc   Ctccctcccc   Gaggcaccat   4440     Tgttccggga   Tcgctgtgac   Cgccacaaag   Tgaatccttt   Cggtgcggac   Agtcgccttc   4500     Aaagccaggc   Cccggattca   Ggtcagggag   Aatctcagct   Cctgagaaat   Ttgctcctgt   4560     Ttgccgcttc   Tgctactcga   Ggaaatgaaa   Cgccattaat   Atttgaaaag   Gcaattattt   4620     Tcctgttgaa   Tcgagaactg   Tcttcatgaa   Taatttgtag   Tgaggtctat   Tgccatttga   4680     Gaaatatttt   Ttttccctct   Ctctctctct   Ctctctctct   Cactctctct   Ctcttctttt   4740     Tatgactagg   Agggggattt   Gagggaaatg   Cccgagcagg   Ccagactctg   Tagttcgttg   4800     Ttggtcgtgt   Ttgtttgttt   Gtttgttttt   Gtttgttgtt   Tcccccaccc   Cccaccgcta   4860     Atgaatcagg   Accgcgaacc   Gaaagaacgc   Acaaaattct   Gtcctgaaaa   Cacgaaaacc   4920     Tgagccagcc   Gtggcgcact   Gaacttgctt   Ctctgctgta   Ggtcgactgt   Gctaagaatt   4980     Taaccatttt   Ctgcttcaca   Gaattcaaac   Agtgggccgg   Caaagagctg   Taaaagtttg   5040     Tttgtttaaa   Aaaaaaaaaa   Aaaaaaccct   Gtcattaaag   Atgagttcct   Tctccagctc   5100     Aggactgcga   Gtctaccttc   Cgggtgtccg   Ccgccagctc   Ccggagtagc   Aggcctgggg   5160     Ccaggattcc   Agtgtgacct   Accgcccctt   Cccgaagcta   Aaacctctgg   Tgagggggtg   5220     Agatccatgc   Gacattgtgg   Gaaaccctga   Aaagaactca   Gggaaaccgt   Acacttccag   5280     Acaagcttta   Gaaataaagt   Gccaggctcc   Aagtggactt   Tggtctggtc   Tccgcatgtg   5340     Ccagtgtccg   Ggccatggac   Cttccccggg   Aagggagagt   Ttggggagaa   Gataggcgtt   5400     Agaacaacta   Gccttaggaa   Gttctttgac   Tccaacaatt   Gtcgatgttc   Cagcaagaat   5460     Aggggcgagt   Aaggcaaggc   Accgggcagt   Aggagaagtg   Gggcaccaag   Ctggaattca   5520     Ttttattttc   Tcctgtcccc   Accagtcccc   Ttctcccgcc   Cccaaaatgg   Gggaggggag   5580     Aagatgttga   Tttcttaaac   Ttccagggag   Gaggagcgag   Aaaaccctaa   Ctaaggagag   5640     Tacaaacaat   Ggctgctaaa   Ctaattaatg   Taacttcaca   Ggctgttctg   Gaagtgtgaa   5700     Aactttctcc   Ttgcagttgt   Attattaga   Gatgctctgg   Cgagaggagt   Tcaattttgc   5760     Aggctcttga   Acgatactcc   Tttttttctg   Ttaactagaa   Gtagcagatg   Tagttgacac   5820     Atgtccccat   Ttcccttagc   Agcttggtaa   Atgatattta   Aggtggatag   Gtctgtgcta   5880     Aagcgaaagt   Gagggtccac   Caaacatccc   Tagtgtccgg   Ccacacaaggc   Tcaaaaatac   5940     Gtacaaagtt   Agcccatcc   Acccccaact   Cttaaagaag   Gctccagggc   Ctggtaacct   6000     Ctcagtccag   Gtgggccagg   Ttatcaggac   Tacaggtgga   Agaggtctgc   Tgcgcaattc   6060     Caaagggaca   Aggaaaaaag   Ttagacagct   Gttcttatgt   Ctttacgact   Ttggggaaca   6120     Atgctgtttt   Aaaatatctt   Aaaatcaaac   Tcttaagcag   Agagcacatg   Tttgcacaca   6180     Cagggtctta   Ggcacgttca   Cccttgtccc   Ccccagaaca   Gaaatcccgc   Actatcctcc   6240     Ccacacacag   Cctccggaaa   Cttctgtgat   Tctaagaata   Gaagcgcata   Atataatatt   6300     Tatggccttg   Gctcatggaa   Acaaccccaa   Aatatttccc   Cctcccctca   Gttgggactt   6360     Gaggaaatcc   Agacccgagg   Gcctgcttcc   Cgagagggtc   Cgcacgcgac   Agacagcgcc   6420     Gaatactgac   Ctgtgtgagt   Tcgtttgtgt   Attttgagat   Tttctgatct   Agcaaagacc   6480     Ttcccacacc   Ccgggaaagg   Acaagggaag   Ggcttctcgc   Ccgtgtgcac   Gcggatgtga   6540     Tttacaagtt   Tgtatttggc   Tttgaagggc   Tttccctggc   Gcggacactc   Ctcccagaag   6600     Caaatgtggt   Tggcctgttc   Cgggccgccg   Acgtgctcca   Cggtgacgtg   Cgtgaccagc   6660     Tcgtgcatgg   Tgctgaaagt   Tttggagcag   Aggctcgggg   Tcgcggtgcc   Gtcggccgcc   6720     Agccacttgc   Agatgagctc   Ctgtttgatg   Ggctggcgca   Tgtagcggaa   Gaaagcgcca   6780     Ggaccgtggg   Gcgcagcgag   Gttcaccgtc   Aggttcatgc   Ccccgtagcc   Atgcagggct   6840     Gcggcagctg   Ccagggcgtc   Gctgcgggcc   Gcaggccctg   Gcgggaaggg   Ctccggccgc   6900     Gcgtacatgt   Ctccagggag   Ccccagacgc   Aggagtccat   Tcaaaggacg   Gctgggggag   6960     Gcctggggag   Gctcctcgtg   Gaggcccggg   Aacaccgagg   Ggctggaggc   Ggcggtgagc   7020     Tgggggccat   Ggtgtccaga   Gctgctacct   Gttgtcgaaa   Caaatagcgc   Gcatgagaac   7080     Gggtggcgtg   Ggctgcgcgc   Tcttccctgg   Gccccggggg   Gcaggcccag   Ccctgccgca   7140     Ctacmggctc   Tgcagtcagc   Cgtggaactc   Agagccagac   Agcgccagca   Gtgaacccgg   7200     Tggacagagc   Aaggccaaac   Acctccgccg   Ccattggggcc   Gaattgctgt   Tgggccaagt   7260     Cccccgccgc   Gccatgagct   Agagagggat   Ggtagcggca   Gagtagatgt   Aaggggtaat   7320     Ggaaggcgca   Gggctgagtc   Tgtgggttgc   Tgggggttct   Gctccagagg   Ggtaggagct   7380     Gagccccaag   Cgcactttgg   Cggctaacac   Cccggggctc   Tccggggcac   Gatgccctgc   7440     Ggggagtgga   Ggtgacagaa   Atgatgatgt   Tggaggtggt   Ggtggttctg   Aagcgcccca   7500     Gccatatata   Ttttcagtgc   Cccgcttggc   Taggagaggg   Cggccggctg   Cttgccgacc   7560     Cacgctcccc   Ggagctccct   Gtaccgggcc   Gctaacacca   Ctgccacctg   Acagtgggga   7620     Ggggaaagga   Aaaccacaca   Aaaaaacttc   Tgtaaagttt   Tttttttctt   Tctttctttc   7680     Tcttcttctt   Cccaaggttt   Ggatttgggc   Gcgcccaccc   Ccttggctat   Taatgcctac   7740     Gcgaaatcct   Gcacactaca   Gaagtagcag   Cagggcgcgt   Taggaagtca   Atagagattc   7800     Agggccgtgg   Cctggaccca   Cagagaggaa   Caatcgcctg   Ggtagcccat   Tggcccgcgg   7860     Ccgggtccga   Cgtcagtgat   Gacaggtcct   Gccgcacgcg   Gtcggtctct   Ctctctctct   7920     Ctcacacttc   Cctgctccaa   Ccgccacccc   Ctcacacacc   Tctcccccaa   Acatataccc   7980     Tctttccctc   Cctcacccca   8000       <210>   100   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   COX7A1     <400>   100   Tgcagcctca   Actcctaggc   Tccagcagtc   Ctcctgcctc   Agcttaccga   Atacctggga   60     Gtacaggcac   Acaccgccat   Gcctggctaa   Tttttaaaat   Tttttgtaga   Gacagggtct   120     Tgctatgttg   Cccaggctgg   Tcttgaactc   Ctgggctcca   Gcaatcctcc   Tacctcagcc   180     Tcccaaagct   Ttggtgttac   Aggcatgagc   Cattgcatgt   Ggccttctga   Gtgttagtgt   240     Actgaatgct   Gaagacatgg   Ctgggaagtg   Gggattactg   Tccttatttt   Gtgaaggagg   300     Aacttaggat   Tcaaggaggc   Aaattttcat   Gctcatagtc   Acccagctag   Gaagttgtaa   360     Agccagaatt   Tgaacttgga   Tctatctgag   Atctgagcta   Agtaagagaa   Ggtaggagca   420     Gtgagcatga   Ttaggtcatg   Caggattgtg   Ggtgccaagt   Ttgggggtgc   Tcaaactcta   480     Cgagagacat   Tggggagcca   Tggcaggttc   Taggcagagg   Gaggacaggg   Tcaggtttgg   540     Ctttagaaag   Atcccttggc   Ctcggctggg   Cacggtggct   Cacgcctgta   Atcccagcac   600     Tttgggaggc   Cgaggagggc   Ggatcacgag   Gtcaggagtt   Cgagaccatc   Ctggctaaca   660     Cagtgaaacc   Ccatctctac   Taaaaataca   Aaaaattagc   Caggtgtggt   Ggcgggcgcc   720     Tgtagtccca   Gctacttggg   Aggctgaggc   Gggagaatgg   Catgaaccca   Ggaggcggag   780     Cttgcagtga   Gctgagatct   Gccactgcac   Tccagcctgg   Gtgacagatc   Gagactccgt   840     Cttaaaaaaa   Aaaaatccct   Tggcctccag   Gccgggtgca   Gtggcttatg   Cctgtaatcc   900     Cagcactctg   Ggaggctgag   Gtgggcgtaa   Aacctgaggt   Caggagttca   Agaccagcct   960     Ggccaacatg   Gcgaaacccc   Gcatctacta   Acgatacaaa   Agttagccag   Gcgtgggggc   1020     Gtgtctgtag   Tcccagctac   Tcaggaggtt   Tagggaggga   Gaattgcttg   Aacccaggaa   1080     Gcggaggttg   Cagtgagcag   Aggtcatgcc   Attgcactcc   Agcctccaac   Ctgggtgaca   1140     Agagcgagat   Tccatctcaa   Aaaaaaaaaa   Gaagaaaaag   Atcccttggc   Ctccagagag   1200     Cccacaatgc   Atgaaaagta   Acagaggaaa   Agaagcaggt   Atgtgagata   Gcagggaggt   1260     Gaagggagtg   Gacagacaag   Gttgatgcca   Caagtcacat   Aagaggggcc   Aggaaatagc   1320     Cactggatct   Accagcaaga   Aggctgatag   Tcgggaggat   Catttgagtc   Caggagtttg   1380     Agaccagcct   Gggcaatgta   Gtaggactcc   Atctctacaa   Aaaaaaaaaa   Atatatgtat   1440     Atagacatag   Ccgggcatgg   Tggcacatgc   Ctgtggtctc   Agttgctcgg   Gaggctgagg   1500     Taggagaatc   Acttgagccc   Gggagggtga   Ggctgcagtg   Agctatgatc   Ttgccactgg   1560     Actccagcct   Gggccacaga   Gacaccgtct   Aaaaaaaaaa   Aaaaaagggc   Tgggcatggt   1620     Ggctcactcc   Tgtaatccca   Gcactttggg   Aggccgaggt   Gggcggatca   Cctgatgtca   1680     Ggagtttgag   Accagcctgg   Ccaacatagt   Gaaaccccgt   Ctctactaaa   Aatacaaaaa   1740     Aattagccag   Gcgtggtggt   Gcacgcctgt   Agtcccagct   Actcaggagg   Ctgaggcagg   1800     Agaatcactt   Gaacctggga   Ggcaaaggtt   Gcagtgagcc   Aagatcgtgc   Cactgcactc   1860     Cagcctgggc   Aacagagtgg   Gactctgtct   Caaaaaaaaa   Aagaaagaaa   Ggcagccagg   1920     Gtgtgcagga   Cgctgtgggt   Atggacacct   Gagggtggtg   Gtaactgagc   Ggagatagtg   1980     Tagtcatcat   Gtctagattc   Cctgtgggtg   Gggaacatgg   Agtcaagttt   Cagggcaggc   2040     Gtggggacct   Acctgtaaga   Ctctaggggc   Aggaagtaga   Gtgtgcagag   Cctccctcta   2100     Gtagcctgtt   Aggcttagaa   Ctggagagga   Tggagcatag   Atgtcagtag   Gaggctgggg   2160     Ctgggcagag   Gtgatatcag   Tacacagagg   Ccattattga   Ggagggtaac   Agattggatt   2220     Ccaatcctga   Tttcttcact   Ttcttgctat   Gtgacctggg   Gcatggcccc   Tcccttcctg   2280     Cctcatttct   Ttttttcctg   Tttttaattt   Ttagtttttt   Taaaaagcag   Agatgaggtc   2340     Tctgttgccc   Aggttggtct   Cgaactcctg   Ggcggctcaa   Gtgatcctcc   Catcttggcc   2400     Ttccaaagtg   Ttgggattat   Aggtgtgagc   Caccacgccc   Agcctgtgcc   Tcattttaaa   2460     Atgacactta   Tctcacagag   Ttggattaaa   Tcagccaata   Cctggaaagc   Actttacccc   2520     Atgcttggca   Cacagtaaat   Actcagtgaa   Gtgccagctg   Ctatgattgt   Catcccatgt   2580     Atttgtgtaa   Tgttattatg   Ccaaaaacca   Gtctccttcc   Ttccctgccg   Ccaaacctct   2640     Gcatctcctc   Ctccaggtgc   Cttcaaatct   Cttgacaaag   Atggcactgg   Acaaatccag   2700     Gtgaacatcc   Aggaggtaag   Gacccccata   Ttggggtatg   Ggtgcctggg   Aggaccccac   2760     Ccctcagccc   Ttcataccag   Ctctgagctg   Cagtcccctt   Cctcctattt   Tgccagccgt   2820     Cctggggtga   Gggcaaaggg   Gctggtgctc   Ttggggttcc   Ctgtcctcac   Tctccaccct   2880     Cctctcccca   Gtggctgcag   Ctgactatgt   Attcctgaac   Tggagcccca   Gacccgcccc   2940     Ctcactgcct   Tgctatagga   Gtcacctgga   Gcctcggtct   Ctcccagggc   Cgatcctgtc   3000     Tgcagtcaca   Tctttgtggg   Gcctgctgac   Ccacaagctt   Ttgttctctc   Agtacttgtt   3060     Acccagcttc   Tcaacatcca   Gggcccaatt   Tgccctgcct   Ggagttcccc   Ctggctctag   3120     Gacactctaa   Caagctctgt   Ccacgggtct   Ccccattccc   Accaggccct   Gcacacaccc   3180     Actccgtaac   Ctctcccctg   Tacctgtgcc   Aagcctagca   Cttgtgatgc   Ctccatgccc   3240     Cgagggccct   Ctctcagttc   Tgggaggatg   Actccagtcc   Ctgcacgccc   Tggcacaccc   3300     Ttcacggttg   Ctacccaggc   Ggccaagctc   Cagaccgtgc   Cagacccagg   Tgccccagtg   3360     Cctttgtcta   Tattctgctc   Ccaggctgcc   Aggcccagga   Ggaaataaac   Atgccccagt   3420     Tgctgatctc   Tatgggatct   Gcctcctgat   Ctgacccgag   Agaggagggg   Tggctcgggc   3480     Tctgggtcct   Ggggagcagg   Ggaggtagta   Gattcgtccc   Cagggctgga   Tccgtggatt   3540     Tcctcgtctt   Tttctcgtcg   Gcattttttg   Tctcatcctg   Agctgtggag   Gctgagacag   3600     Gacccagaag   Ccccagtgat   Ctctgcttct   Gcttccagag   Tctgggctgg   Agggaggtct   3660     Caatgccact   Cctggccctg   Tcccccaagg   Ccatgtttgc   Ccctcttgca   Gcttctccat   3720     Ccacacttgg   Cctctgcctc   Tgttgtgtca   Tggaccatgc   Tcagtgtctt   Ccttcccact   3780     Tgaggacacc   Accccacgtc   Cccgggtccc   Gagggggagc   Ctatagggtcc   Tgtttggggt   3840     Actcagcaga   Gggctgagag   Gtagcaacat   Ctagaggata   Tccctggtcc   Agcatgaggc   3900     Accgagggct   Gggggcagtg   Ggcagtccac   Agggcagaga   Tccctggctg   Gtgggaggat   3960     Gggcttggtg   Gggaggggtg   Gacacaaaca   Cagacacaca   Cagaggccag   Cgtttattga   4020     Cacttgttca   Agtctctcag   Gccccccagg   Cttcttggtc   Ttaattcctg   Gggaaggagg   4080     Cccagccaag   Ggagtacaag   Ctgtagacag   Tgcctagaaa   Ggggaagcgt   Tggagacaga   4140     Atgagaccta   Atccccccc   Tggacatccc   Aggcttttaa   Ggccttcagg   Ctccctggtt   4200     Cccagcctgg   Accccagctc   Tagttcggac   Tccagctccc   Ttcccagatt   Ggactcctat   4260     Tgtaaagccc   Cctggctttg   Atctagaccg   Ggctgggagc   Tttctccccg   Actcctccct   4320     Gggcctcagc   Cccaccacta   Acccagcccc   Cgtcctggga   Caagagccca   Aaccctagtt   4380     Actcccctcc   Ctgcaggcct   Gactccagct   Cagtactcga   Cccccttcct   Aaacgccaac   4440     Ccccaaccca   Gatcctggtc   Agtcctgccc   Agaaaccagc   Cacctcttac   Tctgggtcca   4500     Gccccgcctc   Ccccgcagcc   Cagacgggcc   Ctgcgctcac   Cgcccagaca   Cagcgtcatt   4560     Gtcactcggt   Acaggatgtt   Gtcaacgatg   Ccgcccttca   Ggtacaacgg   Gatgtcattg   4620     Tcctcctgga   Tgtgggggtg   Tctgatgaga   Aaggggtgct   Ggctgctcct   Tagagcgcgc   4680     Cccgcctgcc   Ccggctcggc   Gcgctcccgg   Ctggcgcgtc   Gtagcccccc   Cccccccgac   4740     Cccccacctg   Gaagagcttc   Tgtttctcgc   Gcactcggtt   Ctgaaagcgg   Ttccgggcgg   4800     Tggagctgaa   Ggagcggatc   Agcgcctggg   Acacctgcgg   Ggtgggaggt   Gggcgggtat   4860     Tggaggcacc   Tggaggggtg   Tcctgaagtg   Ggaccccgct   Ctctgaggcc   Tggacgtggg   4920     Gacagcccca   Tccctagcga   Gcgtcccaaa   Ggcgaggagg   Gtaatagctt   Ggattctgtt   4980     Acccgcgaac   Tgccagctgg   Gttgggaggg   Gactcgccct   Ggagtctggc   Ctgggggtga   5040     Ccgggctgcc   Tagagggtcc   Tggaagggag   Aggacccaga   Aggactttgt   Tctggggggc   5100     Ctaagtcctg   Agatttttgt   Tgggggaggg   Tttcctggat   Taaagggagg   Aaaccaggtc   5160     Ccgggaacgt   Ggggaccgga   Atggaggtcc   Ccgggagcgt   Ccaggctgcc   Tgagaaggcc   5220     Cgggtgaggc   Cagtgttaag   Ggttcccgag   Atgtcaagtt   Caaacccggg   Gctttgggcc   5280     Ggggtggggg   Tccccagttg   Tctccgaaga   Gtggattgtg   Ggggaaggga   Cccaggctgt   5340     Ttagcgggga   Gtcccaggcc   Ctgaaggtgg   Ctcacgttcc   Aaggccctag   Atgcgggggc   5400     Acttggagag   Tcgcgtatta   Gggcggggtt   Ttctgggtgg   Ggggctccgg   Cccagcccat   5460     Gggggcctca   Cccgaagggc   Ctgcattctg   Ccttgtcctc   Ttccgccgga   Gtcacctccc   5520     Ttctccgccc   Aaggacacgc   Gtagtcctcc   Tctgtccagg   Aaccccaggc   Cccacccgct   5580     Gcgcgcagcg   Tgacagctgg   Ggacgcggcg   Gggctggggc   Tggggctggg   Gctgggttgc   5640     Ggggagtcct   Gctcctcgga   Ttcgtccacc   Acggaggagg   Cggtccagac   Ccgcaccctg   5700     Ggccgcagcg   Cgcatccgtt   Tcggtctcgg   Aatttcgctt   Ggtcccaccg   Gagcccaaag   5760     Cggtaccagg   Gaatacattt   Ttgcagattt   Ttggagattt   Ccgccggggg   Caagtgcaac   5820     Tcctccccgg   Atctctccct   Gcccgctggt   Atgtgagagt   Gaggaaacgc   Ataaggccgt   5880     Gttccaactc   Cctgttctgt   Ctacacagcc   Agagattgca   Cctccgagcc   Tgtttccgta   5940     Tctgtaacgt   Gagggctaag   Gcaggatctt   Tctcagagat   Ttgttgagac   Attaatagac   6000     Cttgttttta   Ggaaacacaa   Gctaaagtct   Ttgggagtaa   Aacggtattt   Tatgttaccc   6060     Taagaaacac   Atcatatcta   Tttatagctc   Tctaattctg   Gcagtcaacg   Gggtgcagca   6120     Cagttgtcct   Aatggtttta   Gcaaccagga   Aagatcctgg   Ctagmtctac   Aaggttttct   6180     Ttttcttttc   Ttttttttct   Ttttttttta   Gacagggttt   Tgctctgttg   Cacaggctgg   6240     Agtgcagtgg   Tgcggtcata   Gctcactgca   Gcctcgacct   Cctgggttca   Gcgatcctcc   6300     Tgcctcagcc   Tcctgagtgg   Ctgggactac   Aggcgcccac   Caccatgctc   Gaactaattt   6360     Tcgtattttt   Tgtagaggct   Gggtttcacc   Atgttgccca   Ggctggtgtc   Gaactcctga   6420     Gctcaagaaa   Tttgccggcc   Tcatcgtgag   Ccacccaccc   Agccagcaga   Caatgtttgt   6480     Ttgtttgttt   Ttgaggcagt   Gtcttgctat   Gttgcccagg   Gtggtctcca   Actcctccaa   6540     Gtaatgttcc   Tacctctatc   Acccaaagtg   Ctagaattag   Aggcatgagc   Cactataccc   6600     Agcttgtaaa   Aggttttaac   Aatctctttt   Atttatttat   Ttaatttata   Tttttagaca   6660     Gagtcttgct   Ctgttgtaca   Cgttggagtg   Cagtggtgtg   Atctcggctc   Actgaaacct   6720     Tctgcctcct   Gggtttaggc   Aattcttgta   Cctcagcctc   Ctgagcagct   Gggattacag   6780     Gcacccgcca   Ccacacccag   Ctcatttttg   Tattttttag   Tagagatggg   Gttacaccat   6840     Gttggccagg   Ctggtctcaa   Gctcccaacc   Tcaggtgatc   Cgcccacttt   Ggccttccaa   6900     Agtgctggaa   Ttacaggcct   Gagccaccgc   Ttccagccac   Ggtctctttt   Aaagagggct   6960     Tttatgatta   Ttaaattccc   Ctaacacttt   Caaactatgc   Ttgtaaattt   Aatgttaggt   7020     Ttttccattt   Aagagccaca   Agtagggctg   Ggcgtggtgg   Ctcacacctg   Taatcccggc   7080     Actttgggag   Gccaaggcag   Gtggatcact   Tgaggctggg   Agtttgagac   Cagcctggtc   7140     Aacatgacaa   Aaccctgtct   Ctactaaaaa   Tactaaaatt   Aaccaggtgt   Ggtcatgggc   7200     Gcctacaatc   Ccagctgctt   Gtgaggctga   Ggcacaaaaa   Tcgtttgaac   Ccaagaggca   7260     Cggaggctgc   Agtgagccaa   Gattgcacca   Ctgcactcca   Gcttgggtga   Cagaacgaga   7320     Ttctgtctca   Gaaaaaaaaa   Aaaaaaaaag   Ctgacttacc   Agataaacag   Atgactcttt   7380     Cttcaattct   Taaataactt   Tttagaataa   Aaaattcata   Aactgtacat   Aaacagattt   7440     Caagtaagtc   Ttagtcacca   Gctgaattcc   Acattttaca   Atggaattac   Aagattgacc   7500     Tgttatttga   Ataggccagt   Ttccttaaa   Tattacaaat   Tcttaaaata   Ccaagtattc   7560     Acagattctc   Taacacaaag   Ttaataccat   Gggggccagg   Cactgtggct   Cacgccagta   7620     Attccaacac   Tttgggaggc   Cgaggtgggt   Ggatcacctg   Ggtcaggagt   Tcgagaccag   7680     Cctggccagc   Atggtgaaac   Cccgtctcta   Ctaaaaatac   Aaaaattagc   Caggcgtggt   7740     Ggtgggtgcc   Tgtaatccca   Gatactccgg   Aggctgaggc   Aggagaatca   Cttgaacctg   7800     Ggaggcggag   Gttgcactga   Gcagagatta   Cgccattaca   Ctccagcccg   Ggcaagagag   7860     Cgagactcca   Tctcaaaaca   Aaacaaaaca   Aacaagttaa   Tactatggtt   Ttgactgtct   7920     Taattttctt   Ttttcttttt   Tgagacggag   Tcttgctcag   Tcacccaggc   Tggagtgcag   7980     Tggcgccatc   Tcggctcact   8000       <210>   101   <211>   8000   <212>   DNA   <213>   Artificial sequence     <220>   <223>   ECEL1P2     <400>   101   Gctggccggg   Accctgctgc   Tgctggagac   Ggccactgct   Ccctgagtgt   Cccgtccctg   60     Gggctcctgc   Ttccccatcc   Cggagttctc   Ctgctcccca   Cctcctgtcg   Tcctgcctgg   120     Cctccagccc   Gagtcgtcat   Ccccggagtc   Cctatacaga   Ggtcctgcca   Tggaaccttc   180     Ccctccccgt   Gcgctctggg   Gactgagccc   Atgacaccaa   Acctgcccct   Tggctgctct   240     Cggactccct   Accccaaccc   Cagggactgc   Aggttgtgcc   Ctgtggctgc   Ctgcacccca   300     Ggaaaggagg   Gggctcaggc   Catccagcca   Ccacctacag   Cccagtgggt   Accaggcagg   360     Ctcccttcct   Ggggaaaaga   Agcacccaga   Ccccgcgccc   Cgctgatctt   Tgcttcagtc   420     Cttgaatcac   Ctgtgggact   Tgaggactcg   Ggatcttcag   Gacgcctgga   Gaagggtggt   480     Ttcctgccac   Cctgctggcc   Aaggaggctc   Ctggggtggg   Gatcaccagg   Gggattttga   540     Cacagccttc   Ggctgccccc   Cactaagcta   Attccacacc   Cctgtacccc   Cccagggggc   600     Cctctgcctc   Atggcaaagg   Cttgccccaa   Atctcaactt   Ctcagacgtt   Ccataccccc   660     Acatgccaat   Ttcagcaccc   Aactgagatc   Cgaggagctc   Ctgggaagcc   Ctgggtgcag   720     Gacactggtc   Gagagccaaa   Ggtccctccc   Cagacatctg   Gacactgggc   Atagatttct   780     Caagaaggaa   Gactcccctg   Cctccccagg   Gcctctgctc   Tcctgggaga   Caaagcaata   840     Ataaaaggaa   Gtgtttgtaa   Tcccagcact   Ttgggaggcc   Gaggtgggcg   Gatcacgagg   900     Tcaggagatg   Gagaccatcc   Tggctaacac   Ggtgaaaccc   Cttatctatg   Cgcctgtagt   960     Cccagctacc   Caggaggctg   Aagcaggata   Atcgcttgaa   Cccgggcggc   Ggagattgca   1020     Gtgagccgag   Gtcatgccac   Tgcactgcag   Cctgggcgac   Agagcgagat   Tctgcctcaa   1080     Aaataaacaa   Ataaatttta   Aaaataaata   Aataataaaa   Ggaagtgtta   Gacaatgtaa   1140     Tgccagtact   Acttcctagg   Aggaaaatca   Tgagtgcctg   Tgggcacagt   Gtctggaggg   1200     Gtggataacg   Caggccagga   Ggggctgctg   Aggaggagat   Gattgagcag   Gagacctaaa   1260     Cagagtgggg   Cttgagcaag   Gcagaacagc   Agtgccaagg   Ccctggggca   Gcgccagcag   1320     Gtgctctggg   Aggccaaggg   Ctggatcaga   Gggtgggtgg   Gtagaggggt   Aaatctgagg   1380     Gtcaagaggg   Tgggtagtgt   Tggggagtgt   Gaagtctgag   Tagagggatg   Tggttggagg   1440     Tctttaagga   Gtgctgtgac   Ccgccctggg   Tggaaaataa   Gttatctggc   Tgctgccaga   1500     Gaagagggt   Tgtcttttgg   Gtggatggtg   Ggggtggtag   Agggtagcag   Ggagaggtga   1560     Gaactgggga   Aggaactgac   Tccaggtgtt   Tctgatctcc   Gtccgaaagc   Attcgggagc   1620     Acccatccca   Acacagccat   Gcttggtgag   Taccacacct   Gccccaaaag   Aacattgaaa   1680     Gaaatttttt   Tttattgagg   Cagagcctca   Ctctgttcc   Caggctggag   Tgcaatgacc   1740     Ttgtctcggc   Tcactgcaac   Ctctgcctcc   Cagetcaag   Ccattatcct   Gcctcaccct   1800     Cccaagtagc   Caggggtcaa   Caagtgtgca   Ccacatgcc   Tggctagttt   Ttgtattttt   1860     Agtagagacg   Gggtttcacc   Atattggcca   Ggcaggtctc   Caactcctga   Cctcaggtga   1920     Tccacccgcc   Ttggcctccc   Aaagtttggg   Attacaggtg   Tgagccacgt   Gtctggccga   1980     Aaagaattaa   Aggtgaaatc   Agccacattt   Tccagcaaag   Tttacactat   Tacaaaaaat   2040     Acaaaaatta   Gccaagcctc   Gtggcccatg   Cctgtggtcc   Cagctactca   Ggaggctgtg   2100     Gtgggaggat   Cacctgaagt   Gaggagtttg   Agaccagccc   Agccaacatg   Gtgaaactaa   2160     Aactggtcta   Aactaaaaca   Cggtctctac   Taaaactaca   Aaaattagcc   Gggcgtggtg   2220     Gtcggcacct   Gtaatcccag   Ctacttggga   Ggctgaggca   Ggagaattga   Ttgaacctgg   2280     Gaggttgcag   Tgaattgaga   Tcataccact   Gcactccagc   Ctgtgcgaca   Gagccactct   2340     Gtcttaagaa   Aaaaaaaaaa   Gcaagcattt   Tgtgctcact   Gagaatatta   Gcatgattga   2400     Atgcttcctt   Gcatatgaaa   Attattttaa   Cattgtaaaa   Catctatttg   Gcaggcatgg   2460     Cggctcaaca   Cctgcaatca   Cagcactttg   Gcaggaagag   Cgggtaggat   Cgcttgagtt   2520     Caggagtttg   Agaatagcct   Gggcaacata   Gtgagatccc   Gtctctgcaa   Aaacaacaac   2580     Tgagtccagg   Gaggtcgagg   Ctgcagtgaa   Agaagattgc   Tccactgcac   Tctagcctgg   2640     Gcaacagagc   Aagaccctgt   Ctggaaaaat   Atatacatgt   Atttgaggac   Ctggctctct   2700     Caggacagtt   Ttttttcttt   Tctaattcta   Ggttttagtg   Gctgtcataa   Aaatatggga   2760     Ggtgaacaga   Aggtagacac   Cattagctgg   Ccttactaaa   Tcatcatact   Cattgttaca   2820     Ttccatccac   Caaatatgca   Aaggtttg   Taaaatccag   Ctagtgtatt   Tctatcttcc   2880     Cagttgtcag   Tgggttagaa   Agttcctctt   Tctaaccaat   Gtggaggtgc   Tgcatgttta   2940     Ggttttacat   Gagtgctcac   Acccaaggac   Ttctatattt   Taaaagtgaa   Gacattttaa   3000     Aaacagatta   Ttctggccag   Gagttgtggc   Tcatgcttgt   Aatcccagcc   Ttttgggagg   3060     Ccgagacagg   Cagatcactt   Gaggtcagaa   Gtttgagacc   Agcctggcca   Tcatggtgaa   3120     Atcctgtctc   Tactaaaaat   Acaaaaatta   Gccaggtgtg   Gtggcaggca   Ctcgtaatcc   3180     Tagctactca   Ggaggctgag   Acaagagaat   Cgcttgaatc   Cgggaggcag   Aggttgcagt   3240     Gagccgagat   Cgcaccattg   Cactccagcc   Tgggtgacga   Gagtgaaact   Ccatcccaag   3300     Aagaagaaga   Agaaggaaga   Agaagaagga   Agaagaagaa   Gaagaagaag   Aagaagaaga   3360     Agaagaagga   Ggaggaggag   Gaggaggagg   Aggaggagga   Ggaggaggag   Gaggaggaaa   3420     Agaagaagag   Gaggaggaag   Aggaagagga   Ggaggaagaa   Gaggaagaag   Aagaagagga   3480     Ggaagaggaa   Gaggaagaag   Aggaagaaga   Agaagaagaa   Aaagaagaag   Aagaagagga   3540     Aaaagattat   Tctgaaatta   Ggtcattctg   Ttctcaagct   Tccttttcct   Gtgtaggtat   3600     Gagtgtttat   Gagtctaata   Cattgtttac   Cccaaaatca   Agtgtcaaat   Aaatattttc   3660     Aaacttctgc   Tcaaaaattt   Gctctttcct   Tagcaagagt   Tttgttttgt   Ttgagacaga   3720     Gtttcgctct   Tattgcccag   Gctggagtgc   Aatggcgcga   Tctcggctca   Ctgcaacatc   3780     Tgcctcccgg   Gttcaagcaa   Ttctcctgcc   Tcagcctcct   Gagtagctgc   Gattacaggc   3840     Acccgccacc   Acgcccagct   Aagttttggt   Atttttagta   Cccaaagttg   Atgagtcgac   3900     Ctgctccacg   Cgtaatttca   Aggtggtcac   Gttggggtca   Cccctgcag   Cttgtagctg   3960     Ctgtgaacgc   Cagagaatga   Agtactcaga   Caattccagc   Tgagtggggc   Aggcggcaac   4020     Tcctctgaga   Gagtgccgcc   Ccaaaatcca   Tccgccaagt   Atttattaga   Aggcttgtta   4080     Aaccacaaac   Atccaccaga   Tgggtttttg   Ccgtggggtc   Atgaggcaca   Tacggccttg   4140     Taaaagcact   Cagaccacat   Tcctaggagg   Ctgttttcag   Cgctccttat   Cacacattcc   4200     Actccttgtc   Ctgttttcag   Tgtcaaggag   Ttacattctc   Acgcacaaac   Aacgtacaca   4260     Cagtgcctca   Gttattttcc   Atgcctcgag   Ctcaaatgcc   Ttgtacataa   Gtttgaatat   4320     Atcgtcgtgc   Accccccaca   Tctccccctt   Ctttaattct   Tagagcttgc   Tggttatcca   4380     Acgcaaaata   Agcttctatc   Cttcttccct   Ggtcatagat   Gcttcgggtg   Gcagcacaga   4440     Gccatttaca   Gaagcctagc   Aatcagatac   Aaaaaagaat   Atagcggcca   Tcaccctagc   4500     Aatcagatac   Aaaaaagaat   Atagcggcca   Tcacccaaat   Gcgtatgttt   Aacccagaca   4560     Accaagtatt   Cgggttcagt   Cattgaaagc   Cttcttgtaa   Ttgctgaagg   Gttattgttt   4620     Gtaattgctg   Cgagaccatt   Cttcaagttg   Tttcttcaac   Tagacctcaa   Atgctttgta   4680     Cataagcttg   Aatatattgc   Cgcgcacccc   Acccgctccc   Cactgcctgc   Cagagggctg   4740     Ggaaatggct   Gcaccgctga   Acaccgcagt   Taccccgggg   Aaattactta   Tgacctcctc   4800     Ccgcgcgctg   Ccactgtgcg   Ctccctcccc   Tcccctgctt   Tcccttcctc   Tcctctcgcg   4860     Caccctcctc   Ccgccctcag   Ggacccctgg   Gcaaggccac   Tgcgccccgg   Gtctacggca   4920     Gctggcgggg   Cgctcaacgc   Gcgcactcac   Acggacgacg   Tagcgcaaag   Agttcctgtc   4980     Gtccaggctg   Accataagcg   Agaagagcgc   Ggcggcgctg   Tacacgccct   Gcactttttt   5040     Acagcagcca   Gttgaggtcc   Catcgcgcag   Caaccccccg   Gcgctccgcc   Gcgccgcgca   5100     Ggtcccagcc   Cccgcagtcc   Tcgatgacct   Ccagcatgag   Cagcgggttc   Agtcgttcga   5160     Tctcgcgcat   Ctcgaggcac   Aagcggaaga   Aggaggccac   Ctagtgctgg   Gcagcgccgc   5220     Cgggtccacc   Cttgggccga   Gccagcaggc   Gccgcaggcg   Ctcctcgttc   Tgctagccga   5280     Tggccgcgat   Ggtgccgtag   Gtgagcttgt   Cgtcggggat   Ggcatggcgc   Cgcagccagc   5340     Cgccgcaggc   Gaacgagtat   Aagtcctggc   Atgggtcgat   Gctggcgtcc   Aggttggcgg   5400     Ccaagaagcg   Agcggtgcac   Gcgaagtctt   Gcgctcagga   Cagccttcag   Gacaggctcc   5460     Gccgccggcc   Gcgaccgggc   Ccaggtactt   Gagcaccagc   Atagccgcca   Ggatggagca   5520     Gaggccggct   Gcaaacacca   Gcccgacagc   Aggttcaact   Tgcgccgctt   Cgagagctgc   5580     Agcccggcct   Gggcccggtg   Gcctgcgggc   Agaaagtccc   Cgcaagcgcc   Ccccgcgccg   5640     Cagtgactca   Catacttgac   Ctcctggaac   Tcatcgtagt   Gcgccatcag   Cgaataccag   5700     Gactccatgg   Cgccgaggcc   Gccggggtgc   Agccctgggc   Cacctgggct   Acgggatgcg   5760     Cgtggccgcc   Ggcctcctcg   Tgagcctccg   Cgtggcccct   Ggggcctcag   Ctgcgggaag   5820     Gacagaggca   Ggctaatgag   Acgccgcagc   Ccgacggggt   Tccggggcac   Cgcgaggaga   5880     Gacacaggcc   Tgggtgcaga   Ggccccagcc   Gcgagcctca   Ttcactgggg   Aaaccaggga   5940     Ccaggagggc   Tcggcggggc   Caccaccccc   Gcgtgcacag   Tggagtcttc   Tcccctgtcc   6000     Ccctccctgc   Acacacgtgc   Gggtccctgg   Gttgggaggg   Ccctgatggg   Aagggggagg   6060     Agccaggcac   Ggggcctggc   Acgtagtggg   Ccttcattga   Aaggctgtcc   Ctcttccctt   6120     Cgcctttctg   Gtccaggacc   Tgccccagcc   Aaggccgggc   Agaatggggg   Tggggggtgg   6180     Agaagcggag   Gctggagtga   Ggaggtgggg   Tcaggagcgc   Gtctatgctg   Cactttccgc   6240     Tttccgcgct   Ggacacagac   Agaggctcca   Caaagcggcc   Aaagaaccaa   Actttgtcct   6300     Tgcggaagtc   Cgcaggatct   Accactcaac   Cccgatcgct   Ggctccttct   Actcggtggc   6360     Ccgacagccc   Acccgctcct   Tccccagggg   Cgagcgccaa   Cgccccaggg   Tcgtggatac   6420     Acagcccacc   Ccctggacgg   Ccctgatgga   Gaccggctcc   Gtccccccac   Ccacccccat   6480     Tcccagtctg   Tgaccccgac   Ccgagccact   Cccggcttca   Atacgttctc   Cccagaaccc   6540     Aaacttgggt   Gaagtttcac   Ctcccgcggg   Gcgcaaggag   Acgaagccgg   Gaggctccgc   6600     Gcagcggccg   Cgatggcggc   Aacggctgca   Gggattcggc   Gccatttacc   Ccgcaggtgc   6660     Gcactcgagc   Aggaccagga   Ctagcgggcc   Cgctcgaaac   Cagagcctga   Gcctgagcag   6720     Aactgcgtgg   Gcagccgctg   Tctcccagcg   Cccgctgcct   Tttctgccgc   Cgagctgcca   6780     Gcccgagggg   Tccagccgtg   Tcccaggacc   Agtaagggca   Gcgggtactc   Ccgggagggg   6840     Tcccttcgga   Tcccgcgtcc   Ccattacgag   Ctgcccacca   Gccggctaga   Aaggggctgg   6900     Agctacgcag   Ctgggggccg   Tcatgcccca   Gcccacagcc   Ctggagcacc   Ggccggggag   6960     Gactcctcct   Aaaggataag   Ggggccctga   Tggagtgcct   Gggctgcccg   Cacagcgcct   7020     Gcgcaccttc   Accagggagc   Ttccttgtac   Tcctgggaac   Gcctgtccag   Gatgaggtct   7080     Ccccagggcg   Tctgggcttc   Tggttggcct   Cgctcacttc   Ccccagttcc   Tgatccaggg   7140     Agagcaacgg   Agagccctgc   Cagaagaagg   Cttggggctg   Cgagtgcggc   Ccccatggta   7200     Ccaatgcaca   Gttgacccag   Agcacagcaa   Tcgcggccaa   Taggaggtga   Cttgggttta   7260     Gcctgtgacc   Acacagtcct   Ggtcaccctg   Cacagactgc   Caataaagag   Gggtccgagg   7320     Cccagctcct   Tggctcccct   Gcagtgtctc   Caaaagggaa   Gctgaggctg   Tgggtgagtg   7380     Ggtgatgcca   Gtggtccagg   Cccagttcca   Cctgtcacaa   Aggccttctt   Aacctttcat   7440     Cgaaaaatat   Ttctgcaagg   Acatctgccc   Agcaaccacc   Cgtccatcct   Cagactggtg   7500     Ccacccatat   Cctgtatcct   Tgtagccaag   Gataaatatc   Tcaaaacaat   Cctgtgatcc   7560     Tcctccattt   Tcctttaaaa   Acctttgtct   Tccttcacct   Ccctaaattc   Acacgtgctt   7620     Tcctatggcc   Tgcttattcc   Caagcaatac   Ctatttccaa   Agaaagttca   Ttttatttta   7680     Gagtctttct   Gttattgtta   Tgcagtgtca   Catagcggag   Ccagaaggt   Gaccgaagtg   7740     Aattcatctt   Ggatgaatca   Gcgtgtcctg   Gaatctaacg   Cagtgttgac   Tgagcccccc   7800     Gcagactgcc   Tttccaggag   Ttgcttttct   Gttctggtga   Atctcctcaa   Atacccagat   7860     Tccctccctt   Tggtcagttc   Ctttttactt   Tatcctggat   Gtgatttgat   Tataaggctc   7920     Ccttacaaca   Aggaccttagc   Atccctcctg   Agggtataaa   Ggttgggttt   Ctttctttct   7980     Ttctttcttt   Ctttctttct   8000     <210>   102   <211>   7950   <212>   DNA   <213>   Artificial sequence     <220>   <223>   GHSR     <400>   102   Actgaatttt   Taactttaat   Taattttaag   Tttaaaggtt   Taccgttgtt   Tcagttactg   60     Gaaaactttt   Aagtgtgctt   Agacaactta   Gattgttgaa   Tctacttttt   Atctgtaaat   120     Tttatgaaat   Ctaaatacat   Caaatattac   Caatgaaaac   Ttgtgtcca   Aattgagggt   180     Ttctgtaagt   Gtaaaaagca   Tgccagattt   Caaagactta   Gtgtgaaaaa   Aaagaatgta   240     Aattcctttt   Taataatttt   Tgtactgatt   Gctcacgtgc   Ctcatgttat   Atttctcttg   300     Gatagcactg   Ctctagagct   Tttagaaaat   Agctagtttt   Taaaagttac   Attttaaatt   360     Ttgtattgta   Atgtcattct   Tttaaccaaa   Taattttgat   Cattatgaaa   Aagcaaagca   420     Aatttgtatt   Tacctaccaa   Gaagtgccct   Aattgctcac   Tctgctcttc   Ctcctttctc   480     Tgaattgcaa   Agccctcacc   Agcacccgca   Gcagaatgca   Aaatcataga   Cagtgaatat   540     Gcagaaatag   Tgtatgagag   Cactgataat   Tgtgcgatca   Aatcaaactg   Ctcacaccct   600     Acaaatgata   Tcttttttcc   Ctcccagatg   Tttctggatc   Tatgtgttcc   Taattccaaa   660     Attaacctc   Agcttcctcc   Caagttctgc   Tgtgctatgt   Cttccggttt   Agagtaataa   720     Gcggtgactg   Tactcgcaat   Gtgctaggtc   Atgtattaat   Actagattct   Gtccaggccc   780     Gagaactttc   Atctttcaga   Gtggagagct   Ttctctggga   Gaagggttcg   Aatcccagaa   840     Gtctgaacac   Tgccacccgg   Tacttcttgg   Acatgatgtt   Gtacagaatg   Gggttgatgg   900     Cagcactgag   Gtagaagagg   Acaaaggaca   Cgaggttgca   Gtactggctg   Atctgagcaa   960     Tctccaagga   Gccaggctca   Aaggatttgg   Aaaataaata   Tcgccctacg   Tggaagggga   1020     Gccagcagag   Gatgaaggca   Aacaccacta   Cagctaaaag   Gacaatggga   Gagagatagt   1080     Cagctcaaga   Aatgtcacag   Caaatcacat   Tctattttta   Agactttgtt   Tttgtttcat   1140     Ggtctatgac   Cattgacttc   Agagaaacat   Tgtgtcctgc   Tcttcctgtt   Ccaacatttt   1200     Aacaaagatt   Cagtctgtct   Ggaccaacag   Ttcaacaatt   Tttactgagc   Tccccagtca   1260     Tttctattta   Acaactatct   Gagtgatttt   Gtactgagtt   Gacacattga   Ctcaactgac   1320     Tagaccattt   Attcacaata   Gtccagcagt   Ttttatgtgt   Tagacacaac   Agacacactt   1380     Acgaggtaaa   Gtggttgtac   Tcaaccatag   Ctgtgtatcc   Gagtctcctg   Gggcactttt   1440     Taaaacaatg   Cagetcctt   Ggatgtagta   Tagactcagt   Caatttaaat   Ctctaagagg   1500     Gcgatcagga   Catatgtttt   Atcttctctt   Tttttttttt   Aagtttcaca   Gaggattgaa   1560     Tatacagtta   Ggattaagaa   Tcactgagat   Gaatgattct   Atgccactta   Caatagacat   1620     Aagtaaggct   Attattaaac   Caactcatat   Aaattatcat   Ccatccaagt   Cttcattttg   1680     Cctatgtaag   Ataattttta   Atgatgtcta   Aatgtttaga   Ttgttttaaa   Ttcagaaatc   1740     Agggaaaaat   Aataacaaat   Aattttttag   Tcgttgtaac   Actttagtga   Tccccttcaa   1800     Attgtcaagg   Aagaagaaag   Ttaacattgg   Tgttgagaca   Ccaatgaaga   Aattaatggc   1860     Ttgaaaataa   Aattggagga   Aattattaaa   Cttatcctta   Aaactaagtt   Gtatagtagc   1920     Aacttaactg   Ccacagtaac   Aatgtgactc   Tcgtaggtga   Gagcttagga   Tcccttggag   1980     Gacactagca   Ggtttataac   Ctatgagtca   Tatcacgaga   Atcaccggtc   Cagaaaataa   2040     Aatctttgac   Attccttgaa   Taaactctat   Cactttaata   Tggaggatcc   Aggaactgta   2100     Aaattggaaa   Tatgaaatca   Tcctggaatg   Gcttctaaga   Agccttaaaa   Tatgccatta   2160     Agtatgaagt   Cttgactata   Atatctaaat   Aataaaatat   Acagaccttg   Gttttgaaaa   2220     Tgcaagtaga   Gttaatattt   Tgctgggctg   Taaccatatt   Tattattact   Tcacttgtac   2280     Caaacacata   Tacttaaaga   Agctgaattt   Gtgcaataaa   Catcagcaa   Atccagttat   2340     Gacattgtgc   Ccagatgttc   Ctgaagggtc   Atttggggaa   Gtagtgaatt   Ctgttggttt   2400     Ccacaaagc   Tcctttcctc   Ctgttggagc   Tttgtttaat   Ctagtttatc   Cttaccttat   2460     Ctagmtctat   Cctacctgaa   Gaggcaggta   Atcataaaaa   Caaatgagac   Ttcactgatt   2520     Tgtcactgac   Ttccttacaa   Agctgtatga   Acagcagcag   Ggtaaacaga   Attgatgcaa   2580     Tttactgaaa   Aaatgcaggg   Cagaaaacaa   Atcacaatat   Tgaaagaaaa   Atgaataatc   2640     Tctaagagga   Tttaccaaat   Tgatcatgtc   Tttggttgaa   Tttaccgctg   Aacgctttct   2700     Agatccaaac   Cctgcttttc   Tatagttaac   Ttagatattc   Acaaatccta   Cttgaggcag   2760     Gaagtcagtc   Ctcactttta   Acgcttaaag   Accacaatgg   Acttttataa   Gatatctcga   2820     Tttttaaagt   Ggagtttctg   Ggctgatata   Aaatttattt   Tagggaaata   Caaatatggg   2880     Acatttttgc   Atgaaagaga   Gaaaggagag   Acaggaagaa   Agagacacaa   Agagatagag   2940     Acggtaagaa   Agacactgac   Aaagtaaagg   Gggaggagag   Agagagacag   Agacagagag   3000     Aaagattgag   Agatcaaaaa   Catcactcaa   Gaaagcaaga   Ggagagaata   Attgagagaa   3060     Acgcagagag   Acagaggccc   Agagaaactg   Aagaaagagg   Tagcgactca   Gggggaaata   3120     Gagatggaga   Ctcagagaga   Agggagaagg   Cacagggaga   Ggataggacc   Cgcgagagaa   3180     Agcctgagcg   Cgcgctgaga   Cccacccagc   Attttcacgg   Tttgcttgtg   Gttctggtcc   3240     Ctgagcgagg   Cacccacgac   Agcatcgccg   Cgcctcctcc   Gccacagctt   Cctgccgatg   3300     Agactgtaga   Ggaccgtgag   Acagaagaca   Ggaaggaaga   Agaagatgct   Ggacacccac   3360     Accatgaccg   Tgagcagtcc   Agagcgcacc   Gcaaactcgg   Tggggcggca   Ctcgttggtg   3420     Tcccaagggt   Cggtgccgtt   Ctcgtgctcc   Accccgacta   Gcacgaagat   Gggcccggcg   3480     Ctgcagaagg   Ccacggccca   Gatgacgaag   Atgaccagct   Tcacccgccc   Cttggtgacc   3540     Accaccttgg   Cccggagtgg   Gaagcagatg   Gcgaagtagc   Gctcgacgct   Cagcgctgtg   3600     Atggtgagca   Ccgtggcgta   Ggtgcagctc   Tcactgacga   Attggaagag   Tttgcagagg   3660     Aggtcgccga   Agttccaggg   Ccggtactgc   Cagaggcgaa   Cgaggtccag   Gggcatgcag   3720     Aggaagatga   Gcagatcgga   Gaaggccatg   Ctggacaggt   Agaggttggt   Ggtggtgcgc   3780     Agctcgcgga   Agcgcgacac   Caccagcatg   Gtgagcaggt   Tgccagcgat   Gcccaccacg   3840     Aagagtgcca   Cgcaggtggc   Tgtgacgccc   Gccagcagcg   Gcgcggggaa   Gagctgcagc   3900     Agctcgtcgc   Ccagggagtc   Gttgccgggg   Gaagcatccc   Agtccaggtc   Ggccagtgtg   3960     Aggttgaacc   Ccggctcttc   Gctgggcgtc   Gcgttccaca   Tgctgccggc   Tcagctgaac   4020     Aggctctggg   Acgtgactgc   Gctgggaggc   Tggaccgagc   Tggctcccga   Ggaggtccgc   4080     Ttaggcgcgg   Gagggtgcga   Gggaggagcg   Ggtgcagacg   Cgtagggagg   Atgcttggag   4140     Aagaaagaga   Gggaggtgag   Aggcagaagc   Cgaggaagaa   Ggtgagatgg   Ggacaaggaa   4200     Gagggagaga   Gactggtggt   Cagtgggtga   Gagagtgacc   Cactgctttc   Tctgacacct   4260     Cccctttccc   Ccaccaactc   Ccccaaagtt   Tctcccaaca   Catcctccgg   Ccggcgccca   4320     Cacgcatacc   Tgtcaccagc   Cctgcctcgc   Atttgcgttc   Tcgatccagt   Tccatctcgc   4380     Acttcccaaa   Gcgtcgcagc   Gagtggggac   Cgcagggacc   Aggcgccgcg   Aagcgggagc   4440     Gtgaggcgct   Ctctccgaag   Ccctgggcga   Cgctggacta   Gtgtgccccg   Gaaggacagg   4500     Tcacacccgg   Gggtgggggt   Gaagacgacg   Gtggcggtgg   Ggaggacacc   Tttagcagct   4560     Gggacctgat   Ttcttcctcc   Acaaggctgc   Agctggctat   Ggccctggtg   Gaaagaaaaa   4620     Gcgagcttga   Ccaactcgac   Ttgggaaggg   Ggatagagag   Agaaaagaag   Gaccttgtgt   4680     Ttgtattcat   Accggtgagc   Accaaagaat   Agtctcacgc   Agttatagga   Cccaggttca   4740     Gcgatgtgac   Tacttgtcca   Aggtcacaca   Gcgagctggg   Gactcgggga   Ccagtgtcgg   4800     Atctcccacc   Cggttgggac   Ttctgagcgc   Acaggggcaa   Gatatgtgag   Taaaccctgt   4860     Cgagaatccc   Agtcctttgt   Atcactcggt   Agtggtagag   Agtctgctgt   Agggtatatt   4920     Acttttgctt   Gatgcaaacc   Tggtggcggg   Gtgccgaggt   Tggtcaggga   Gggaacagga   4980     Gaaaggaaaa   Aggcagggtt   Ggaggtgtgt   Ggaggcggca   Agtgaagaag   Aggctgtgag   5040     Gctggcgcgt   Cgagagtgtg   Caggaaacat   Tttttgaggc   Ataactgaga   Gagatcagcc   5100     Atttagtagc   Cgtattccct   Tgggcaaggt   Cttcaacctc   Ctgagcatta   Cgtctttttc   5160     Tttgaattgc   Aatgatttgt   Gcggaccact   Gggggtgata   Tcaagtgtca   Gggaccaccg   5220     Gaggcactca   Ataaatagaa   Gacgcgttgc   Tgttgagaag   Tagaagctgt   Gccggtggga   5280     Acaggtcaaa   Ggccacccct   Acactagcaa   Ggtgaccctc   Tggacgcggt   Ctgtgcgtct   5340     Cctgctcaga   Gccagaaatc   Agcacccgaa   Ggcatgagac   Tgccagttgc   Cagcgaattc   5400     Acaaatccga   Ccggcccctc   Ccggcccacc   Gacctcggga   Ccgccccagg   Aacatattca   5460     Gcactgtggc   Cagcgccaca   Tccatcctac   Cgcaaagcgc   Cgctggagga   Atggcttccc   5520     Tgtcactccc   Accgttttta   Acttgcgctt   Ctaacgcctc   Agtcctaccc   Cacggaggag   5580     Cagggcagac   Tcccacgaag   Cacaggccgg   Cgttagtcac   Tgccttgacc   Atacacatcg   5640     Gcgctcaccc   Gatgagatac   Cacgtactgt   Gtatgagaga   Gtatccccct   Cagttgaatg   5700     Cgtttgtact   Tgcctttcac   Agagagttg   Taccacctct   Actacctaaa   Ttgttaatac   5760     Ttaaaagtcc   Acaaagacct   Aagactgaat   Gtgtgcacaa   Atgcgtgaaa   Gactccatgc   5820     Agtaaattac   Tacatgagag   Aagtttgata   Caggaaattt   Aacatagtgg   Tttggttgcc   5880     Gctggtgtgt   Tagacattgg   Accaaactga   Gttttgtttc   Gttttgcttt   Gttttgtttt   5940     Gttttgctgg   Ttttgttttg   Ttttgttttg   Agacggagtc   Tccctctgtc   Gcccaggctg   6000     Gagtgcagtg   Gcgcgatctc   Tgctcactgc   Aacctccgcc   Tcccagtatt   Ggatctccca   6060     Cccgtttgga   Cttctgagcg   Cataagcca   Ggttcaagca   Actcttctgc   Ctcagtctct   6120     Ctagtagctg   Ggactacagg   Cgtgtgccac   Cacgcctgga   Taattttttt   Ttgtattttt   6180     Agaagagaca   Gggtttcacc   Atactggcca   Gtcttgtctc   Gaactcctga   Cctcgtgatc   6240     Tgcccgcctc   Ggtctcccaa   Agtgctggga   Ttacagccgt   Gagccactgt   Gcccggcccc   6300     Aaattgagtt   Tttaaaacat   Taatttcaga   Ctactatttt   Ttaagtatta   Caactaagtc   6360     Aaactaccaa   Ttacaaacaa   Gtttttattt   Aatcaataac   Tttgttactc   Cctgacctat   6420     Attattaggta   Ggttgatgta   Tgtggaaaga   Aagggagaga   Aagtggactg   Gtagataatca   6480     Gaatactatg   Ggaagttatt   Gcctaagact   Gagaatcagg   Aaaatattgt   Tggatatatt   6540     Tctagtctac   Tcagtgctaa   Agctatggct   Gazatttgaa   Aaaactgaaa   Acaaaaacca   6600     Ccaaaactat   Tgtgataaaa   Aaaattttca   Tgttagctaa   Aatagccagc   Catttaatgg   6660     Cactcaacca   Gtttctaaaa   Tatagacaaa   Tctatattgc   Atgaccaaga   Agaaacagag   6720     Ggtgctattg   Tagttgctct   Atttattcac   Aacatgtgaa   Atattatgta   Ataccgtata   6780     Taaaactatc   Tctagtaagt   Ggtaggtact   Aggataacaa   Aataaataaa   Acccagacag   6840     Atcctatatt   Tataaactta   Tagtctagag   Gaagaaatac   Agttaaataa   Gtaatgctag   6900     Tacagtattg   Ataggtgcat   Ttaaagaggc   Atgtacaatg   Agccctgttg   Gaattcagag   6960     Aatgaatgaa   Ccacgtggag   Gctttaggga   Aggcctctca   Gaggaagcag   Catctgagct   7020     Ggatcttgga   Aaagttcagt   Tccatcagaa   Aaaggaaaac   Ttgctcaacc   Attcagacaa   7080     Cggacacaaa   Agcattttgg   Agtgacattc   Agtatgcctt   Gttctatgaa   Tggtgtaaag   7140     Agattattatta   Ttgacttgtg   Gatttttata   Tagtaagtgc   Ataccaatca   Gttacggcga   7200     Ttgttttctt   Ttagacactc   Aaattgtccc   Atctttggcc   Aatgagatcc   Acttcaagtt   7260     Ggttccaggg   Tccttttgac   Ataactcact   Tagattttta   Gagcttacat   Gctgtgtttt   7320     Gtggcacaat   Gagatgcctc   Aagctcacct   Tgtaaattct   Ccacactata   Cctaggagca   7380     Accattattt   Caagaatccc   Tggtatccgc   Agtgggaaac   Agcatttaga   Gaccaacatt   7440     Tgggcagtgg   Ggttggttat   Tatccctgga   Gcattatggt   Ctaggttctg   Cagacaaagg   7500     Taggatatat   Acatatgtat   Acacattata   Tgtatattct   Atacatataa   Ataaagttac   7560     Atagtttcca   Tttagaagat   Gtaccttagt   Ttcatttaac   Cagtttattg   Ataaatattt   7620     Gtgagttttt   Aataatcttt   Tattgctata   Atatatatat   Tgctatatat   Tctatacata   7680     Tatatggtgt   Gtattatatat   Aggctatgta   Ctatatacat   Atatatacac   Atatatagat   7740     Gagtgtgtgt   Ataatcatta   Tcatctcaca   Atatctagat   Atctataaat   Catgagatga   7800     Taattatgat   Actgtagata   Aatcagacag   Accctgagca   Gatgaacaaa   Actaacatca   7860     Ccactatgat   Accctgggaa   Ggacacaatg   Tcacttatat   Gcattccagc   Tagaaacgaa   7920     Gaacctcaat   Ctaatcacaa   Ggaaacatca   7950

Claims (90)

A method for assessing the degree or malignancy of a tumor in a patient with an ovarian tumor, comprising the steps of: (a) collecting the same copy from the patient; (b) determining the methylation status of at least one of the target genes in the sample, wherein the at least one target The gene is selected from the group consisting of TMEM132D, IRX1, MIR124-2, TRH, PCDHB4, ZNF132, KLHL33, DPP6, ADCY8, C20orf85, C17orf46, FOXI2, HIST1H4I, HIST1H2BB, SLC6A3, HTR1A, CDO1, CDH8, PCDHGA5 , COL14A1, SPAG6, RAX, PRDM14, HIST1H3E, ZIC1, COX7A1, ECEL1P2, and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; (c) determining whether the at least one target gene is highly transgenic And (d) evaluating the tumor malignancy or prognosis of the patient based on the result of the step (c), wherein if the at least one target gene is highly methylated, the patient is judged to have a malignant ovarian tumor or a prognosis Not good. The method of claim 1, further comprising the steps of: (e) determining a methylation status of a GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene; and (f) determining Whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated, wherein in the step (d), based on the results of the steps (c) and (f), Determining a tumor malignancy or prognosis in the patient, wherein if the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated and the at least one target gene is highly methylated, then The patient was judged to have a malignant ovarian tumor or had a poor prognosis. The method of claim 1, wherein: the at least one target gene is selected from the group consisting of ADCY8, CDO1, HIST1H4I, ECEL1P2, HTR1A, SPAG6, CDH8, DPP6, HIST1H3E, PCDHGA5, RAX, C17orf46, COL14A1, FOXI2, PRDM14, ZIC1, HIST1H2BB, MIR124-2, TRH, and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; and if the at least one target gene is highly methylated, the determination is made The patient has a malignant ovarian tumor. The method of claim 1, wherein: the at least one target gene is selected from the group consisting of MIR124-2, TRH, PCDHB4, ZNF132, KLHL33, C20orf85, C17orf46, HIST1H4I, HIST1H2BB, CDO1, CDH8, PCDHGA5, COL14A1, SPAG6, HIST1H3E, ZIC1, COX7A1, ECEL1P2, and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; the prognosis is associated with progression-free survival; and if the at least one target gene is produced Highly methylated, the patient's disease-free progression was determined to be poor. The method of claim 1, wherein: the at least one target gene is selected from the group consisting of: TMEM132D, IRX1, KLHL33, DPP6, ADCY8, FOXI2, SLC6A3, HTR1A, CDO1, CDH8, RAX, PRDM14, and A polynucleotide sequence having at least 75% sequence similarity to any of the above genes; the prognosis being associated with overall survival; and if the at least one target gene is highly methylated, the overall survival is determined to be poor. The method of claim 1, wherein: the at least one target gene is selected from the group consisting of HIST1H2BB, HIST1H3E, HIST1H4I, and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; And this prognosis is associated with progression-free survival. The method of claim 6, further comprising the steps of: (e) determining a methylation status of a HIST1H3C gene or a polynucleotide sequence having at least 75% sequence similarity to the HIST1H3C gene; and (f) determining Whether the HIST1H3C gene or the polynucleotide sequence having at least 75% sequence similarity to the HIST1H3C gene is highly methylated; wherein in the step (d), the result is determined based on the results of the step (c) and the step (f) The prognosis of the patient, wherein the HIST1H3C gene or a polynucleotide sequence having at least 75% sequence similarity to the HIST1H3C gene is highly methylated and HIST1H2BB, HIST1H3E or HIST1H4I and at least 75% sequence similar to any of the foregoing genes If at least one of the polynucleotide sequences is highly methylated, the patient is judged to have poor disease progression and poor survival. The method of claim 6, wherein if at least two of the target genes are highly methylated, the disease progression progression of the patient is determined to be poor. The method of claim 1, wherein the at least one target gene is TRH, the prognosis is related to the disease-free progression survival, and the method further comprises the steps of: (e) determining the GHSR gene or having at least the GHSR gene a methylation status of a polynucleotide sequence of 75% sequence similarity; and (f) determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated, Wherein in the step (d), the prognosis of the patient is determined based on the results of the steps (c) and (f), wherein the GHSR gene or the polynucleotide sequence having at least 75% sequence similarity to the GHSR gene A hypermethylation of the polynucleotide sequence that is highly methylated and the TRH or at least 75% sequence similarity to TRH is highly prognostic, the patient is judged to have poor disease progression and poor survival. The method of claim 1, wherein the sample is a tissue, a cell, a tumor, or a biological fluid taken from a patient. The method of claim 10, wherein the sample is a serum or plasma sample. The method of claim 11, wherein the at least one target gene is FOXI2 or MIR124-2. The method of claim 10, wherein the sample is taken from a cervical scraping cell. The method of claim 13, wherein the at least one target gene is selected from the group consisting of MIR124-2, TRH and FOXI2. The method of claim 2, wherein the sample is taken from a cervical scraping cell. The method of claim 15, wherein the at least one target gene is selected from the group consisting of MIR124-2, TRH and FOXI2. The method of claim 1, wherein the methylation status is methylation-specific polymerase chain reaction (MSP), quantitative methylation specificity polymerase chain reaction (quantitative methylation) -specific polymerase chain reaction; qMSP), bisulfite sequencing (BS), bisulphite pyrosequencing, microarrays, mass spectrometry, denatured high liquid phase Denaturing high-performance liquid chromatography (DHPLC), pyrosequencing, methylated DNA immunoprecipitation and quantitative polymerase chain reaction (methylated DNA immunoprecipitation (MeDIP or mDIP) coupled with quantitative polymerase chain Reaction), methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing. A method for assessing whether an individual has an ovarian tumor, comprising the steps of: (a) collecting the same copy from the individual; (b) determining a methylation status of at least one of the target genes in the sample, wherein the at least one target gene is selected From the following group: TMEM132D, IRX1, MIR124-2, TRH, PCDHB4, ZNF132, KLHL33, DPP6, ADCY8, C20orf85, C17orf46, FOXI2, HIST1H4I, HIST1H2BB, SLC6A3, HTR1A, CDO1, CDH8, PCDHGA5, COL14A1 , SPAG6, RAX, PRDM14, HIST1H3E, ZIC1, COX7A1, ECEL1P2, and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; (c) determining whether the at least one target gene is highly methylated And (d) evaluating whether the individual has an ovarian tumor based on the result of the step (c), wherein if the at least one target gene is highly methylated, the individual is determined to have an ovarian tumor. The method of claim 18, further comprising the steps of: (e) determining a methylation status of a GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene; and (f) Determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated, wherein in the step (d), based on the results of the steps (c) and (f) Determining whether the individual has an ovarian tumor, wherein if the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated and the at least one target gene is highly methylated, then the determination is made The individual has an ovarian tumor. The method of claim 18, wherein the at least one target gene is selected from the group consisting of MIR124-2, CDO1, HTR1A, and TRH. The method of claim 18, wherein the sample is a tissue, cell, tumor or biological fluid taken from the individual. The method of claim 21, wherein the sample is a serum or plasma sample. The method of claim 22, wherein in the step (d), the subject has an ovarian tumor, and the method further comprises determining the ovarian tumor based on a methylation status of FOXI2, MIR-124, or a combination thereof. Whether it is malignant. The method of claim 21, wherein the sample is taken from a cervical scraping cell. The method of claim 24, wherein the at least one target gene is selected from the group consisting of MIR124-2, TRH and FOXI2. The method of claim 25, wherein in step (d), the subject has an ovarian tumor, and the method further comprises determining the ovary based on a methylation status of MIR124-2, TRH, FOXI2, or a combination thereof. Whether the tumor is malignant. The method of claim 19, wherein the sample is taken from a cervical scraping cell. The method of claim 27, wherein the at least one target gene is selected from the group consisting of MIR124-2, TRH and FOXI2. The method of claim 18, wherein the methylation status is measured by methylation specificity polymerase chain reaction (MSP), quantitative methylation specificity polymerase chain reaction (qMSP), sulfite Order (BS), sulfite pyrophosphate sequencing, microarray, mass spectrometry, denaturing high liquid chromatography (DHPLC), pyrophosphate sequencing, methylated DNA immunoprecipitation (MeDIP or mDIP) and quantification Polymerase chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing. A method of assessing whether an individual has malignant ovarian cancer, comprising the steps of: (a) collecting the same copy from the individual; (b) determining the methylation status of at least one of the target genes in the sample, wherein the At least one of the underlying genes is selected from the group consisting of ADCY8, CDO1, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, MIR124-2, and a multinucleus having at least 75% sequence similarity to any of the above genes. And (c) determining whether the at least one target gene is highly methylated, wherein if the at least one target gene is highly methylated, the individual is determined to have malignant ovarian cancer. The method of claim 30, further comprising the steps of: (d) determining a methylation status of a GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene; and (e) determining Whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated, wherein the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene occurs Highly methylated, the individual is judged to have malignant ovarian cancer. The method of claim 31, further comprising the steps of: (f) determining a methylation status of a HIST1H3C gene or a polynucleotide sequence having at least 75% sequence similarity to the HIST1H3C gene; and (g) determining Whether the HIST1H3C gene or a polynucleotide sequence having at least 75% sequence similarity to the HIST1H3C gene is highly methylated, wherein the HIST1H3C gene or a polynucleotide sequence having at least 75% sequence similarity to the HIST1H3C gene, The GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have malignant ovarian cancer. The method of claim 30, wherein the at least one target gene comprises CDO1, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2. The method of claim 31, wherein the at least one target gene comprises CDO1, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2. The method of claim 32, wherein the at least one target gene comprises CDO1, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, and MIR124-2. The method of claim 30, wherein the at least one target gene comprises CDO1, FOXI2, TRH, and MIR124-2. The method of claim 31, wherein the at least one target gene comprises CDO1, FOXI2, TRH, and MIR124-2. The method of claim 30, wherein the sample is a tissue, cell, tumor or biological fluid taken from the individual. The method of claim 38, wherein the sample is a serum or plasma sample. The method of claim 39, wherein the at least one target gene is FOXI2 or MIR124-2. The method of claim 38, wherein the sample is taken from a cervical scraping cell. The method of claim 41, wherein the at least one target gene is selected from the group consisting of FOXI2, MIR124-2, and TRH. The method of claim 31, wherein the sample is taken from a cervical scraping cell. The method of claim 43, wherein the at least one target gene is selected from the group consisting of FOXI2, MIR124-2, and TRH. The method of claim 30, wherein the methylation status is methylation specificity polymerase chain reaction (MSP), quantitative methylation specificity polymerase chain reaction (qMSP), sulfite sequencing ( BS), sulfite pyrophosphate sequencing, microarray, mass spectrometry, denaturing high liquid chromatography (DHPLC), pyrophosphate sequencing, methylated DNA immunoprecipitation (MeDIP or mDIP) and quantitative polymerase Chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing. A method of assessing whether an individual has an ovarian tumor comprises the steps of: (a) collecting the same copy from the individual; (b) determining a methylation status of at least one of the target genes in the sample, wherein the at least one target gene is selected from the group consisting of a group consisting of: ADCY8, CDO1, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, TRH, FOXI2, MIR124-2, and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; c) determining whether the at least one target gene is highly methylated, wherein if the at least one target gene is highly methylated, the individual is determined to have an ovarian tumor. The method of claim 46, further comprising the steps of: (d) determining a methylation status of a GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene; and (e) determining Whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated, wherein the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and If at least one of the target genes is highly methylated, the individual is judged to have an ovarian tumor. The method of claim 46, wherein the at least one target gene comprises ADCY8, CDO1, HIST1H2BB, HIST1H3E, HTR1A, TRH, FOXI2, and MIR124-2. The method of claim 47, wherein the at least one target gene comprises ADCY8, CDO1, HIST1H2BB, HIST1H3E, HTR1A, TRH, FOXI2, and MIR124-2. The method of claim 46, wherein the at least one target gene comprises CDO1, HTR1A, TRH, and MIR124-2. The method of claim 47, wherein the at least one target gene comprises FOXI2, CDO1, HTR1A, TRH, and MIR124-2. The method of claim 46, wherein the sample is a tissue, cell, tumor or biological fluid taken from the individual. The method of claim 52, wherein the sample is a serum or plasma sample. The method of claim 53, wherein in the step (d), the individual determined in the step has an ovarian tumor, and the method further comprises determining the methylation status based on FOXI2, MIR124-2, or a combination thereof. Whether the ovarian tumor is malignant. The method of claim 52, wherein the sample is taken from a cervical scraping cell. The method of claim 55, wherein the at least one target gene is selected from the group consisting of MIR124-2, TRH and FOXI2. The method of claim 56, wherein in step (c), the subject to be tested has an ovarian tumor, the method further comprising determining the ovary based on a methylation status of MIR124-2, TRH, FOXI2, or a combination thereof Whether the tumor is malignant. The method of claim 47, wherein the sample is taken from a cervical scraping cell. The method of claim 58, wherein the at least one target gene is selected from the group consisting of MIR124-2, TRH and FOXI2. The method of claim 59, wherein in the step (c), the subject has an ovarian tumor, the method further comprising determining whether the ovarian tumor is based on the methylation status of MIR124-2, TRH, FOXI2 or a combination thereof It is malignant. The method of claim 46, wherein the methylation status is methylation specificity polymerase chain reaction (MSP), quantitative methylation specificity polymerase chain reaction (qMSP), sulfite sequencing ( BS), sulfite pyrophosphate sequencing, microarray, mass spectrometry, denaturing high liquid chromatography (DHPLC), pyrophosphate sequencing, methylated DNA immunoprecipitation (MeDIP or mDIP) and quantitative polymerase Chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing. A method of assessing whether an individual has malignant ovarian cancer comprises the steps of: (a) collecting the same sample from the individual, wherein the sample is taken from a cervical scraping cell; (b) determining at least one target gene in the sample a methylation condition, wherein the at least one target gene is selected from the group consisting of TRH, FOXI2, MIR124-2, and a polynucleotide sequence having at least 75% sequence similarity to any of the foregoing genes; And (c) determining whether the at least one target gene is highly methylated, wherein if the at least one target gene is highly methylated, the individual is determined to have malignant ovarian cancer. The method of claim 62, further comprising the step of: (d) determining, by the method of step (b), methylation of a GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene. And (e) determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated by the method of step (c), wherein the GHSR gene or the GHSR The polynucleotide having at least 75% sequence similarity of the gene and the at least one target gene are highly methylated, and the individual is judged to have malignant ovarian cancer. The method of claim 62, wherein the methylation status is methylation specificity polymerase chain reaction (MSP), quantitative methylation specificity polymerase chain reaction (qMSP), sulfite sequencing ( BS), sulfite pyrophosphate sequencing, microarray, mass spectrometry, denaturing high liquid chromatography (DHPLC), pyrophosphate sequencing, methylated DNA immunoprecipitation (MeDIP or mDIP) and quantitative polymerase Chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing. A method of assessing whether a body has an ovarian tumor comprises the steps of: (a) collecting the same sample from the individual, wherein the sample is taken from a cervical scraping cell; (b) determining at least one target gene in the sample a methylation condition, wherein the at least one target gene is selected from the group consisting of TRH, MIR124-2, and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; c) determining whether the at least one target gene is highly methylated, wherein if the at least one target gene is highly methylated, the patient is determined to have an ovarian tumor. The method of claim 65, further comprising the step of: (d) determining, by the method of step (b), methylation of a GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene. a condition; and (e) determining, by the method of step (c), whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated, wherein the GHSR gene or the GHSR The polynucleotide having at least 75% sequence similarity of the gene and the at least one target gene are highly methylated, and the individual is judged to have an ovarian tumor. The method of claim 65, wherein the methylation status is methylation specificity polymerase chain reaction (MSP), quantitative methylation specificity polymerase chain reaction (qMSP), sulfite sequencing ( BS), sulfite pyrophosphate sequencing, microarray, mass spectrometry, denaturing high liquid chromatography (DHPLC), pyrophosphate sequencing, methylated DNA immunoprecipitation (MeDIP or mDIP) and quantitative polymerase Chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing. A method for assessing whether an individual has malignant ovarian cancer comprises the steps of: (a) collecting a single fluid sample from the individual; (b) determining a methylation status of at least one of the target genes in the body fluid sample, wherein the at least one target The gene is selected from the group consisting of FOXI2, MIR124-2, and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; and (c) determining whether the at least one target gene is highly raised Methylation, wherein if the at least one target gene is highly methylated, the individual is determined to have malignant ovarian cancer. The method of claim 68, wherein the sample is a serum or plasma sample. The method of claim 68, wherein the methylation status is methylation specificity polymerase chain reaction (MSP), quantitative methylation specificity polymerase chain reaction (qMSP), sulfite sequencing ( BS), sulfite pyrophosphate sequencing, microarray, mass spectrometry, denaturing high liquid chromatography (DHPLC), pyrophosphate sequencing, methylated DNA immunoprecipitation (MeDIP or mDIP) and quantitative polymerase Chain reaction, methylated DNA immunoprecipitation sequencing (MeDIP-seq) or nanopore sequencing. A method for assessing whether an individual has a bladder tumor using a body bladder sample comprises the steps of: (a) determining a methylation status of at least one target gene in the bladder sample, wherein the at least one target gene is selected from the group consisting of Group consisting of: ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH, Z1C1 and any of the above a polynucleotide having at least 75% sequence similarity; and (b) determining whether the at least one target gene is highly methylated, wherein the at least one target gene is highly methylated, the individual is determined Have a bladder tumor. The method of claim 71, further comprising the steps of: (c) determining, by the method of step (a), a GHSR gene in the bladder sample or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene. a methylation status; and (d) determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated by the method of step (b), wherein the GHSR gene Or the polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have a bladder tumor. A method for assessing whether a breast tumor is diagnosed using a breast sample of a body comprises the steps of: (a) determining a methylation status of at least one target gene in the breast sample, wherein the at least one target gene is selected from the group consisting of Groups: ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH, Z1C1 and any of the above genes a polynucleotide sequence of at least 75% sequence similarity; and (b) determining whether the at least one target gene is highly methylated, wherein if the at least one target gene is highly methylated, determining that the individual has Breast tumor. The method of claim 73, further comprising the steps of: (c) determining, by the method of step (a), a GHSR gene in the bladder sample or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene. a methylation status; and (d) determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated by the method of step (b), wherein The GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have a breast tumor. A method for determining whether a subject has a cervical tumor using a body of a cervical scraping sample, comprising the steps of: (a) determining a methylation status of at least one of the target genes in the cervical scraping sample, wherein the at least A target gene is selected from the group consisting of: ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH And Z1C1 and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; and (b) determining whether the at least one target gene is highly methylated, wherein if at least one of the target genes is highly Based on the basis, the individual is judged to have a cervical tumor. The method of claim 75, further comprising the steps of: (c) determining, by the method of step (a), a GHSR gene in the bladder sample or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene. a methylation status; and (d) determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated by the method of step (b), wherein the GHSR gene Or the polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have a cervical tumor. A method for determining whether an individual has a colorectal tumor using a large colon sample of a body comprises the steps of: (a) determining a methylation status of at least one of the target genes in the large intestine sample, wherein the at least one target gene is selected from the group consisting of Group consisting of: ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH, Z1C1 and any of the above a polynucleotide having at least 75% sequence similarity; and (b) determining whether the at least one target gene is highly methylated, wherein the at least one target gene is highly methylated, the individual is determined Have a large intestine. The method of claim 77, further comprising the steps of: (c) determining, by the method of step (a), a GHSR gene in the large intestine sample or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene. a methylation status; and (d) determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated by the method of step (b), wherein the GHSR gene Or the polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have a colorectal tumor. A method of assessing whether an individual has an endometrial tumor comprises the steps of: (a) collecting the same copy from the individual; (b) determining a methylation status of at least one of the target genes in the sample, wherein the at least one target The gene is selected from the group consisting of CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, SPAG6, TRH, PRDM14, Z1C1 and at least 75% of any of the above genes. a polynucleotide sequence of sequence similarity; and (c) determining whether the at least one target gene is highly methylated, wherein if the at least one target gene is highly methylated, the individual is determined to have an endometrium tumor. The method of claim 79, further comprising the steps of: (d) determining, by the method of step (a), a GHSR gene in the sample or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene; a methylation condition; and (e) determining, by the method of step (b), whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated, wherein the GHSR gene or The polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have endometrioma. The method of claim 79, wherein the sample is taken from endometrial cells. The method of claim 81, wherein the at least one target gene is selected from the group consisting of PRDM14, TRH, MIR124-2, Z1C1, and FOXI2. The method of claim 79, wherein the sample is taken from a cervical scraping cell. The method of claim 83, wherein the at least one target gene is selected from the group consisting of PRDM14, TRH, MIR124-2, Z1C1, and FOXI2. A method for determining whether an individual has a liver tumor using a liver sample of a body comprises the steps of: (a) determining a methylation status of at least one of the target genes in the liver sample, wherein the at least one target gene is selected from the group consisting of Group consisting of: ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH, Z1C1 and any of the above a polynucleotide having at least 75% sequence similarity; and (b) determining whether the at least one target gene is highly methylated, wherein the at least one target gene is highly methylated, the individual is determined Have a liver tumor. The method of claim 85, further comprising the steps of: (c) determining, by the method of step (a), a GHSR gene in the liver sample or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene. a methylation status; and (d) determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated by the method of step (b), wherein the GHSR gene Or the polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have a liver tumor. A method for determining whether an individual has a oral cavity using a single oral scraping sample, comprising the steps of: (a) determining a methylation status of at least one target gene in the oral scraping sample, wherein the at least one target gene Selected from the group consisting of ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH, Z1C1 and a polynucleotide sequence having at least 75% sequence similarity to any of the above genes; and (b) determining whether at least one of the target genes in the oral scrap sample is highly methylated, wherein at least one of the targets If the gene is highly methylated, the individual is judged to have a mouth tumor. The method of claim 87, further comprising the steps of: (c) determining, by the method of step (a), the GHSR gene in the oral scraping sample or a polynucleoside having at least 75% sequence similarity to the GHSR gene. a methylation status of the acid sequence; and (d) determining whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated by the method of step (b), wherein The GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have an oral cavity. A method for determining whether an individual has osteosarcoma using a single osteosarcoma sample comprises the steps of: (a) determining a methylation status of at least one of the target genes in the osteosarcoma sample, wherein the at least one target gene is selected from the group consisting of: The group consisting of: ADCY8, C17orf46, CDH8, CDO1, COL14A1, DPP6, ECEL1P2, FOXI2, HIST1H2BB, HIST1H3E, HIST1H4I, HTR1A, MIR124-2, PCDHGA5, PRDM14, RAX, SPAG6, TRH, Z1C1 and the above a polynucleotide having at least 75% sequence similarity in any sequence; and (b) determining whether at least one of the genes in the osteosarcoma sample is highly methylated, wherein if at least one of the target genes is highly Upon methylation, the individual is judged to have osteosarcoma. The method of claim 89, further comprising the steps of: (c) determining, by the method of step (a), a GHSR gene in the osteosarcoma sample or a polynucleotide having at least 75% sequence similarity to the GHSR gene; a methylation status of the sequence; and (d) determining, by the method of step (b), whether the GHSR gene or a polynucleotide sequence having at least 75% sequence similarity to the GHSR gene is highly methylated, wherein the GHSR The gene or the polynucleotide sequence having at least 75% sequence similarity to the GHSR gene and the at least one target gene are highly methylated, and the individual is judged to have osteosarcoma.