KR102326582B1 - Marker for diagnosing hearing impairment and deafness and use thereof - Google Patents

Abstract

Provided are an estrogen related receptor β (ESRRB) genetic variant, a composition or a kit for diagnosing hearing impairment and deafness, containing an agent capable of specifically detecting the genetic variant, and a method for diagnosing the disease using the same, in which the ESRRB genetic variant according to an aspect can be used as a marker for diagnosing hearing impairment and deafness. Diagnosis using the ESRRB genetic variant enables accurate early diagnosis of hearing impairment through genetic testing, and accordingly, recently-developing treatment methods can be applied early to maximize a therapeutic effect.

Description

Marker for diagnosing hearing impairment and deafness and use thereof

A composition or kit for diagnosing hearing impairment and deafness comprising an estrogen related receptor β ( ESRRB ) gene variant and an agent capable of specifically detecting the same, and diagnosis of the disease using the same it's about how

Hearing impairment and deafness is a condition in which the ability to hear sounds is significantly reduced or not heard at all. Hearing impairment is diagnosed when one or more ears cannot hear sounds below 25 decibels on a hearing test. Deafness is when you cannot hear sound at all, or when you cannot communicate with sound alone, even if you have residual hearing, and when you can communicate using your residual hearing with the help of a hearing aid, it is called “hearing loss.” .

Hearing loss is the most common sensory disease, and it is largely divided into hereditary and non-hereditary hearing loss, and more than 50% of them are hereditary hearing loss. Hereditary hearing loss is classified into Syndromic Hearing Loss, in which clinical symptoms of other organs appear together other than due to inner ear dysfunction, and Nonsyndromic Hearing Loss, in which there are no abnormal symptoms of other organs other than inner ear dysfunction and only deafness. Syndromic hearing loss accounts for about 30% and nonsyndromic hearing loss accounts for about 70%. In the case of nonsyndromic hearing loss, autosomal recessive inheritance accounts for about 80%, about 15% to 20% of autosomal dominant inheritance, and less than about 2% of hearing loss due to genes present in the X chromosome and mitochondria. do.

Recently, with the development of human genome research and bioinformatics, research to isolate the causative genes of genetic diseases and to elucidate molecular biological mechanisms is being actively conducted. Although important, the development of an effective diagnostic method for hearing impairment is still insufficient. Accordingly, the inventors of the present invention identified a novel mutated gene that had not been previously reported as a result of intensive research efforts to identify the cause of the deafness, and confirmed that the mutated gene can be usefully used for the diagnosis of hearing impairment. was completed.

Republic of Korea Patent Publication No. 10-2019-0043845.

One aspect provides an estrogen related receptor beta ( ESRRB ) gene variant.

Another aspect provides a composition for diagnosing whether or at risk of developing hearing impairment and deafness.

Another aspect provides a kit for diagnosing whether or not the onset of deafness comprising the composition or the risk of the onset.

Another aspect provides a method of providing information for diagnosing a hearing impairment or predicting a risk of developing a hearing loss.

One aspect provides an ESRRB gene variant comprising a nucleotide sequence in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A).

The ESRRB gene variant may be an isolated ESRRB gene variant.

The ESRRB gene is a gene encoding an estrogen-related receptor β (ERR-β) protein, and may be a gene registered as NCBI Accession number NM_004452.3 or NG_012278.2, for example, SEQ ID NO: 1 or It may be a gene comprising the nucleotide sequence represented by 2. The nucleotide sequence represented by SEQ ID NO: 2 is a sequence including an exon region and an intron region. In addition, the ERR-β protein may be a protein registered as NCBI Accession number NP_004443.3.

As used herein, the term "exon (exon)" refers to a portion encoding a protein, and "intron" is included in a gene, but does not encode an actual protein, and RNA splices before being translated into a protein It means the non-encrypted part that is removed through the sync process.

As used herein, the term " ESRRB gene variant" may mean that a mutation has occurred in a portion of the nucleotide sequence of the ESRRB gene including the nucleotide sequence represented by SEQ ID NO: 1 or 2. Specifically, it may be an ESRRB gene variant in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A). In addition, it may be an ESRRB gene variant comprising a nucleotide sequence in which guanine (G), which is the 111,414th base in the nucleotide sequence of SEQ ID NO: 2, is substituted with adenine (A).

As used herein, the term "c.787+1G>A" means a mutation in which guanine (G), the intron site base immediately after base 787 of the coding sequence of the ESRRB gene, is substituted with adenine (A). can Since the mutation site is included in the splice site, protein mutation may be induced by selective splicing or abnormality in the splicing process due to the mutation.

The ESRRB gene variant may be generated by point mutation of the ESRRB gene.

A person skilled in the art will be able to easily identify the position of the mutation and the nucleotide sequence using the registration number. The specific sequence corresponding to the number registered in the UCSC genome browser or GenBank may be slightly changed over time. It will be apparent to those skilled in the art that the scope of the present invention also extends to such altered sequences.

ESRRB gene variant comprising a nucleotide sequence in which guanine (G), which is the intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or position 111,414 in the nucleotide sequence of SEQ ID NO: 2 The ESRRB gene mutant comprising a nucleotide sequence in which guanine (G) as a base is substituted with adenine (A) may be a diagnostic marker for deafness. Accordingly, the c.787 +1G>A mutation site of the ESRRB gene mutant may be a mutation marker for the diagnosis of deafness.

As used herein, the term "hearing impairment and deafness" is a disorder in which the ability to hear sounds is significantly reduced or not at all. The case where communication is impossible is called "deafness", and the case where communication is possible using residual hearing with the help of a hearing aid is called "hearing loss". The hearing impairment may be due to a hereditary cause, for example, may be hereditary deafness.

As used herein, the term “diagnosing” refers to ascertaining the presence or characteristics of a pathological condition. Therefore, the "diagnosis of hearing impairment" may mean confirming whether or not the onset or possibility of the onset of hearing impairment or predicting the risk of onset.

As used herein, the term "diagnosis marker" may refer to a substance capable of diagnosing whether or not the onset of the hearing impairment or the possibility of the onset of the hearing impairment.

Selection and application of significant diagnostic markers can determine the reliability of diagnostic results. A significant diagnostic marker may refer to a marker with high reliability because the result obtained by diagnosis is accurate, and thus has high validity and shows consistent results even during repeated measurement. As the diagnostic marker, an ESRRB gene variant comprising a nucleotide sequence in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or the nucleotide sequence of SEQ ID NO: 2 The ESRRB gene variant, which contains a nucleotide sequence in which guanine (G), which is the 111,414th base in the Therefore, a diagnosis result based on a result obtained by detecting the presence or absence of the variant is reasonably reliable.

Another aspect is an agent capable of specifically detecting a polynucleotide comprising a nucleotide sequence in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A) It provides a composition for diagnosing whether or not the onset of hearing impairment or the risk of the onset, including.

The composition may include an agent capable of specifically detecting a polynucleotide including a nucleotide sequence in which guanine (G), which is the 111,414th base in the nucleotide sequence of SEQ ID NO: 2, is substituted with adenine (A).

As used herein, the term "agent capable of specifically detecting a polynucleotide" refers to a substance that can be used to specifically identify or detect the polynucleotide in a sample of an individual.

The agent capable of specifically detecting the polynucleotide may be a substance that specifically binds to the ESRRB gene mutant, specifically, a substance that specifically binds to the c.787+1G>A mutation site of the ESRRB gene mutant. number and, more specifically, may be a c.787 + 1G> a mutant polynucleotide that specifically binds to a region of the mutant gene ESRRB, more specifically, specific for c.787 + 1G> a mutation region of the mutant gene ESRRB enemy It may be a primer, a probe, or an antisense nucleic acid that binds to , but the type is not necessarily limited thereto.

The agent capable of specifically detecting the polynucleotide is a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 1 or 2 or a complementary polynucleotide thereof, wherein the polynucleotide includes a mutation site of the polynucleotide and is selected from the polynucleotide 10 It may be a polynucleotide comprising two or more contiguous nucleotides.

An agent capable of specifically detecting the polynucleotide is one that exhibits a nucleotide mutation at a mutation site. Therefore, when one single-stranded polynucleotide is associated with the risk of developing deafness, the polynucleotide complementary to the single-stranded polynucleotide may naturally be determined to be associated with the risk of developing deafness. Accordingly, a composition according to an aspect may include a single-stranded polynucleotide associated with a risk of developing deafness having one specific sequence and a polynucleotide having a complementary sequence thereto. The agent capable of specifically detecting the polynucleotide may detect the c.787+1G>A mutation in the polynucleotide comprising the nucleotide sequence of SEQ ID NO: 1 or 2.

The primer, probe or antisense nucleic acid is a polynucleotide comprising a nucleotide sequence in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or SEQ ID NO: 2 It may be that it specifically binds to a polynucleotide containing a nucleotide sequence in which guanine (G), which is the 111,414th base in the nucleotide sequence, is substituted with adenine (A) and does not specifically bind to the nucleotide sequence of another nucleic acid material. The primer, probe or antisense nucleic acid can be designed by a person skilled in the art based on the nucleotide sequence of the ESRRB gene variant.

As used herein, the term "primer" refers to a nucleic acid sequence having a short free 3' hydroxyl group, capable of forming a base pair with a complementary template and copying the template strand. It refers to 7 to 50 nucleic acid sequences that serve as starting points for Primers are usually synthesized but can also be used on naturally occurring nucleic acids. The sequence of the primer does not necessarily have to be exactly the same as the sequence of the template, but only if it is sufficiently complementary to hybridize with the template. A primer can initiate a polymerization reaction at an appropriate buffer solution and temperature, i.e., DNA synthesis in the presence of reagents for DNA polymerase or reverse transcriptase and four different nucleoside triphosphates. PCR conditions, the length of the sense and antisense primers can be modified based on what is known in the art. Therefore, deafness can be diagnosed by PCR amplification using sense and antisense primers of the nucleotide sequence region of the ESRRB gene variant.

As used herein, the term "probe" refers to a nucleic acid fragment such as RNA or DNA corresponding to several bases to several hundred bases as short as possible to achieve specific binding to mRNA, and is labeled with a specific nucleic acid existence can be checked.

The probe may be manufactured in the form of an oligonucleotide probe, a single stranded DNA probe, a double stranded DNA probe, an RNA probe, or the like. Selection of appropriate probes and hybridization conditions can be modified based on those known in the art. Therefore, hybridization is performed using a probe complementary to the nucleotide sequence of the ESRRB gene mutant, and hearing impairment can be diagnosed based on the hybridization.

The primer or probe may be chemically synthesized using a phosphoramidite solid support method, or other well-known methods. Such nucleic acid sequences may incorporate additional features that do not change their basic properties. Examples of additional features that may be incorporated include, but are not limited to, methylation, encapsulation, substitution of one or more nucleic acids with homologs, and modifications between nucleic acids.

The term "antisense nucleic acid" as used herein refers to complementary with SEQ ID NO's ESRRB gene variants with molecules of the nucleic acid base which may form a dimer about the ESRRB gene mutant to target and to detect the ESRRB gene mutants can be used

The antisense nucleic acid may be the polynucleotide or a fragment thereof, or complementary thereto. The fragments are 5 or more, specifically 10 or more, more specifically 10 to 1000, even more specifically 10 to 500, even more specifically 15 to 500, even more specifically 15 to 300 Dogs, more specifically 15 to 200, more specifically 15 to 150 nucleotides may be used, but an appropriate length may be selected in order to increase detection specificity.

Another aspect provides a kit for diagnosing whether or not the onset of deafness comprising the composition or the risk of the onset.

The kit is a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1 in the test subject, is substituted with adenine (A), or the nucleotide of SEQ ID NO: 2 By specifically detecting a polynucleotide including a nucleotide sequence in which guanine (G), which is the 111,414th base in the sequence, is substituted with adenine (A), it is possible to diagnose whether or not the onset of deafness or the risk of the onset.

Specifically, the kit is a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1 in the test subject, is substituted with adenine (A), or SEQ ID NO: Whether or not hearing impairment occurs by specifically detecting the c.787+1G>A mutation site of a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the 111,414th base in the nucleotide sequence of 2, is substituted with adenine (A); You can diagnose the risk of developing it.

The kit includes a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or 111,414 in the nucleotide sequence of SEQ ID NO: 2 A primer, probe, or antisense nucleic acid capable of specifically detecting a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the second base, is substituted with adenine (A) may be included, and in addition thereto, one or more suitable for analysis Other component compositions, solutions or devices may be included.

The kit may be an RT-PCR kit or a microarray chip kit.

The RT-PCR kit is a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or the nucleotide of SEQ ID NO: 2 In order to specifically detect the c.787+1G>A mutation site of a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the 111,414th base in the sequence, is substituted with adenine (A), RT-PCR is required to perform It may contain essential elements. For example, the RT-PCR kit is a polynucleotide comprising a nucleotide sequence in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or a sequence In addition to each pair of primers specific for the c.787+1G>A mutation site of a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the 111,414th base in the nucleotide sequence of No. 2, is substituted with adenine (A), a test tube or Other suitable containers, reaction buffers, deoxynucleotides (dNTPs), enzymes such as Taq-polymerase and reverse transcriptase, DNase, RNase inhibitors, DEPC-water, sterile water, and the like may be included.

The microarray chip may include a DNA or RNA polynucleotide probe. The microarray is a polynucleotide comprising a nucleotide sequence in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or in the nucleotide sequence of SEQ ID NO: 2 Configuration of a conventional microarray except for including a probe specific for the c.787+1G>A mutation site of a polynucleotide containing a nucleotide sequence in which guanine (G), the 111,414th base, is substituted with adenine (A) may include. The microarray is a polynucleotide comprising a nucleotide sequence in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or in the nucleotide sequence of SEQ ID NO: 2 By detecting the presence or absence of the c.787+1G>A mutation site of a polynucleotide containing a nucleotide sequence in which guanine (G), which is the 111,414th base, is substituted with adenine (A), information useful for diagnosing the possibility of developing deafness can provide

A polynucleotide comprising a nucleotide sequence in which guanine (G), which is the intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or base 111,414 in the nucleotide sequence of SEQ ID NO: 2 A method for preparing a microarray by immobilizing a probe for the c.787+1G>A mutation site of a polynucleotide containing a nucleotide sequence in which guanine (G) is substituted with adenine (A) on a substrate is well known in the art. have. For example, the DNA microarray is, but not limited to, c.787 by a method using a micropipetting or a pin-type spotter using a piezoelectric method. A probe for the +1G>A mutation site can be immobilized on a substrate. The substrate of the microarray may be coated with an active group selected from the group consisting of amino-silane, poly-L-lysine, and aldehyde, but is not limited thereto. In addition, the substrate may be one selected from the group consisting of slide glass, plastic, metal, silicon, nylon membrane, and nitrocellulose membrane, but is not limited thereto.

In addition, hybridization of nucleic acids on microarrays and detection of hybridization results are well known in the art. In the detection, the nucleic acid sample is labeled with a fluorescent substance, for example, a label capable of generating a detectable signal including a substance such as Cy3 and Cy5, and then hybridized on a microarray and a signal generated from the labeling substance. By detecting the hybridization result can be detected.

In another aspect, in order to provide information for diagnosing deafness or predicting the risk of developing a hearing impairment, in a biological sample isolated from an individual, guanine (G), an intron site base immediately after the 787th base of the nucleotide sequence of SEQ ID NO: 1 A method for detecting a polynucleotide comprising a nucleotide sequence substituted with this adenine (A) is provided.

The method may be to detect a polynucleotide including a nucleotide sequence in which guanine (G), which is the 111,414th base in the nucleotide sequence of SEQ ID NO: 2, is substituted with adenine (A).

As used herein, the term "individual" refers to an individual who wants to determine whether or not the onset of hearing impairment or the possibility of onset or predict the risk of onset. The subject may be a vertebrate, specifically mammals, amphibians, reptiles, birds, etc., may be more specifically a mammal, for example, a human ( Homo sapiens ).

As used herein, the term "biological sample" may include, but is not limited to, a sample such as tissue, cells, whole blood, serum, plasma, saliva, sputum, cerebrospinal fluid, or urine isolated from an individual. Methods for obtaining a biological sample from a subject are known in the art. In the case of a nucleic acid sample, the nucleic acid can be directly isolated from tissue, cells, whole blood, serum, plasma, saliva, sputum, cerebrospinal fluid or urine, or a nucleic acid in which a specific region is amplified by a nucleic acid amplification method such as PCR can be used. The nucleic acid may be DNA or RNA. The DNA may be genomic DNA, cDNA or recombinant DNA. The RNA may be mRNA. The nucleic acid sample includes not only purely isolated nucleic acids, but also crudely isolated nucleic acids, for example, cell lysates containing nucleic acids.

The method may be to directly determine and detect the nucleotide of the polynucleotide mutation site in the biological sample. Methods for determining nucleotides are known in the art. For example, a nucleotide sequencer may be used to directly determine the nucleotide of a polynucleotide variation site. The nucleotide of the mutation site can be directly determined by a nucleotide sequencing method of a known nucleic acid. Methods for determining nucleotide sequencing may include Sanger (or dideoxy) sequencing methods, next-generation sequencing, next-generation sequencing, or Maxam-Gilbert (chemical cleavage) methods.

The method may be to detect the polynucleotide using an agent capable of specifically detecting the polynucleotide. Specifically, the agent capable of specifically detecting the polynucleotide may be a primer, a probe, or an antisense nucleic acid, but is not limited thereto.

The method for detecting the polynucleotide may be to use an assay selected from the group consisting of reverse transcription polymerase reaction, competitive reverse transcription polymerase reaction, real-time reverse transcription polymerase reaction, RNase protection assay (RPA), Northern blotting and DNA chip. However, it is not limited thereto.

In the above method, in a biological sample isolated from an individual, a polynucleotide comprising a nucleotide sequence in which guanine (G), which is an intron site base immediately after base 787 of the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A), or If there is a mutation c.787+1G>A of a polynucleotide comprising a nucleotide sequence in which guanine (G), which is the 111,414th base in the nucleotide sequence of SEQ ID NO: 2, is substituted with adenine (A), deafness has occurred or there is a risk of developing it It can be diagnosed as having

"Risk of developing a hearing impairment" may be a relative risk of developing a hearing impairment. For example, the risk of developing the disease may indicate whether the probability of developing the disease is increased compared to a healthy normal group or a group having a reference genomic sequence. In addition, the risk of onset may indicate whether an individual having a specific allele or genotype has an increased probability of developing a hearing impairment compared to an individual having another specific allele or genotype.

The ESRRB gene mutant according to an aspect may be used as a marker for diagnosing hearing impairment. Diagnosis using the ESRRB gene mutant enables accurate early diagnosis of hearing impairment through genetic testing, and accordingly, treatment effects that have been recently developed can be applied early to maximize the therapeutic effect.

1 is a pedigree of a family including a deaf patient with an ESRRB gene mutation c.787+1G>A. The white figure means normal, and the black figure means hearing impaired patients. The genotype of the ESRRB gene mutation site is shown at the bottom of each member, a slash (/) indicates a deceased individual, and an asterisk (*) indicates a proband.
FIG. 2 is a nucleotide sequence chromatogram including an ESRRB gene mutation site in a family member including a deaf patient having an ESRRB gene mutation c.787+1G>A.

Hereinafter, the present invention will be described in more detail through examples. However, these examples are for illustrative purposes of one or more embodiments, and the scope of the present invention is not limited to these examples.

Example 1. Identification of genetic mutations associated with hearing impairment

Example 1-1. Selection of test subjects

Genetic mutations were investigated in families including hearing impaired patients (Family ID: DF6), and the control group was 500 normal people.

Example 1-2. Identification of genes responsible for hearing loss

Among the blood samples of the test subject family selected in Example 1-1, the causative gene was identified in the deaf patient.

Specifically, peripheral blood was obtained from the family member, and genomic DNA was extracted using the QIAamp blood DNA purification kit (Qiagen, Hilden, Germany), followed by an automatic sequencing analyzer ABI3130XL and Genemapper software (Life Technologies, Foster City, CA, USA) was used for genotyping. In addition, the SureSelect Human All Exon 50M kit (Agilent Technologies, Santa Clara, CA, USA) was used to capture whole exon and exon flanking sequences, followed by a HiSeq2000 genomic analyzer (Illumina, San Diego, CA, USA). were sequenced according to the standard paired-end mode sequencing protocol. Whole exome sequencing (WES) was performed at Macrogen (Seoul, Korea). UCSC assembly hg19 was used as a reference sequence.

Small nucleotide variants (SNVs) were extracted using the GATK program, and the variants were annotated using the ANNOVAR program. Sequences were extracted only when the read depth was 5 or more. Annotated SNVs were compared to variants registered in dbSNP150 (http://www.ncbi.nlm.nih.gov).

Potential functionally important mutations (missense, nonsense, exonic indel, stop gain and splicing sites) were first identified from the data. was selected. Then, novel or rare variants (minor allele frequency (MAF) less than 0.01) were further filtered using the 1000 Genomes Project (http://www.1000genomes.org/). Candidate causative variants were identified by Sanger sequencing method using the ABI3130XL genetic analyzer. MUpro (http://www.ics.uci.edu/~baldig/mutation), PolyPhen-2 (http://genetics.bwh.harvard.edu/pph2), and SIFT (http://sift.jcvi. org), and in silico analysis was performed. Genomic evolutionary rate profiling (GERP) scores were determined using the GERP++ program (http://mendel.stanford.edu/SidowLab/downloads/gerp/index.html).

As a result of the analysis, as shown in Table 1 and FIG. 1 , it was confirmed that the c.787+1G>A mutation of the ESRRB gene was present in an individual exhibiting a deaf phenotype among the test subject families.

number gender/age relationship phenotype DF6-1 M/35 father - DF6-2 female/33 Mother - DF6-3 female/7 sister - DF6-4 M/9 brother deaf DF6-5 female/4 sister - DF6-6 M/3 me deaf DF6-10 M/32 Uncle - DF6-11 female/30 aunt -

In addition, as shown in Table 2, the total eksom from sequence analysis to cause mutation of the hearing loss, was confirmed c.787 + 1G> A variation of the ESRRB gene, which is the novel mutation is unknown or the like dbSNP150, 1000 Genome Project It was confirmed that

transition Nucleotides (Nt) c.787+1G>A heredity Autosomal recessive (AR) human genome database 1000G (Oct 2011) - In silico analysis dbSNP150 - GERP 5.54 SIFT - PolyPhen2 - Mupro -

With respect to the ESRRB gene of the family selected in Example 1-1 including a deaf patient, the base at the mutation site was confirmed by the Sanger sequencing method.

As a result, as shown in FIG. 2 , it was confirmed that all ESRRB alleles in deaf patients had c.787+1G>A mutation.

SEQUENCE LISTING <110> Samsung Life Public Welfare Foundation KONGJU NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION Dong-A University Research Foundation For Industry-Academy Cooperation <120> Marker for diagnosing hearing impairment and deafness and use it <130> PN130971KR <160> 2 <170> PatentIn version 3.2 <210> 1 <211> 2658 <212> DNA <213> Homo sapiens <400> 1 atgtcctcgg acgacaggca cctgggctcc agctgcggct ccttcatcaa gactgagccg 60 tccagcccgt cctcgggcat cgatgccctc agccaccaca gccccagtgg ctcgtccgac 120 gccagcggcg gctttggcct ggccctgggc acccacgcca acggtctgga ctcgccaccc 180 atgtttgcag gcgccgggct gggaggcacc ccatgccgca agagctacga ggactgtgcc 240 agcggcatca tggaggactc ggccatcaag tgcgagtaca tgctcaacgc catccccaag 300 cgcctgtgcc tcgtgtgcgg ggacattgcc tctggctacc actacggcgt ggcctcctgc 360 gaggcttgca aggccttctt caagaggact atccaaggga acattgagta cagctgcccg 420 gccaccaacg agtgcgagat caccaaacgg aggcgcaagt cctgccaggc ctgccgcttc 480 atgaaatgcc tcaaagtggg gatgctgaag gaaggtgtgc gccttgatcg 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ttcacaagca gggatcagag caactccccg gggatcccca atccacgccc ttctagtcca 1440 acccccctca atgagagagg caggcagatc tcacccagca ctaggacacc aggaggccag 1500 ggaaagcatc tctggctcac catgtaacat ctggcttgga gcaagtgggt gttctgcaca 1560 ccaggcagct gcacctcact ggatctagtg ttgctgcgag tgacctcact tcagagcccc 1620 tctagcagag tggggcggaa gtcctgatgg ttggtgtcca tgaggtggaa gctgctttta 1680 tacttaaaac tcagatcaca acaggaaatg tgtcagtaac aatggaactc catccaatgg 1740 gaaagttcct ggtactgaag gggtccattg gacactcaga aaagaagttc aggggccaac 1800 ttcttagctg gaatcctggc cagatgagga ccctctccgg ggaagggaga ggactgactt 1860 agtggaaggt ggtgaagtga ggagagttta ggggaacctt cccccagtgg aacagatctc 1920 aagtttaccc taaacctgcc atttctggaa aatctgtaaa gaggaaacag cctgtctcag 1980 ctgtactctc atgatacagg tcatttgaaa tgaaccaaga aataaaacat gaaaatccaa 2040 ccatggagaa ggtggtatgg ctgggttttg tttggtcccc ttgtccttat acgttctaaa 2100 gtttccagac tggctttgtc actttgtgaa ctcgtcatgt gtgaaaacca atctttgcat 2160 atagggaact tcctcgggcc acactttaag aaccaagtaa gaggctctca agactccagc 2220 agagtcggga ggccatggca gcgccttaga ggagctggaa cctgcaccca cctgtgtcgg 2280 tggggggggc ctcctttccc catagactct gccctccctc tgtgcagatg gaagtggcag 2340 gggagggtga ccagcttgtg acaagaagac tgaagggtcc agagtccatg ctcacggaac 2400 agcaccaaag aaaagcacta tgtggaaaga ttgttttatt ttctaataat gataatatgg 2460 ctggaatggc ttcttaagat gtatatattt tttaaaatgg cagttcccca ttgcagcatc 2520 acctacttgt atgtctttct gcctctgtat atgttctccc agaaaccccc atgtaaatca 2580 aatgccctag gatgcttcca tcctggtccc atgtatctgg aatctaataa ataaggaaag 2640 gaaaaaaaaaaaaaaaaaa 2658 <210> 2 <211> 130491 <212> DNA <213> Homo sapiens <400> 2 ccgcagagag gtgtggtcag ggacatttcc cctggccggg agcccatgga gcactgtcct 60 cagagatgcg caggttaggc tcactgtcta ggccaggccc accttagtca ctgtggactg 120 gcaatggaag ctcttcctgg acacacctgc cctagccctc accctggggt ggaagagaaa 180 tgagcttggc ttgcaactca gaccattcca cggaggcatc ctccccttcc tgggctggtg 240 gtaagaagtg gctacatact gtgggtgttt ctgaaggtat cattcccacc tggaagcttg 300 gcttcaggaa aatggggatg ggtgagggac agggatggca taaacaaaca gttagcattc 360 ctacactcac tggatttaga gagcatgtgg cagattctcc aaaaatgcct gttgggtctt 420 gtcttttagt gaggaagccg tcaagtcctc tactctcctg gggaccaagc tggctccacc 480 agcttctgct aagttgcctg gcttgaaagg tggaggaagt atcctcctat tgttggtcct 540 aggggagcat atggcaggga ggggatttga ggacctaaga gacactgctt gctgctgcct 600 catttgtgca aaaatggctg gtgtctgggg aggctgcctc aagagaggga agatactacc 660 aagactggat tccattaaga gtggagattt tcacccgacc tctggcaaga gttgctgtgc 720 tgggttagac tgcatatatc atgacgagac tgctctagtg acccttgaga tctgggcctt 780 ggagtaggat ggcataccct gaggacttag gcaggctggg gtgggaaagg gcgggtggtt 840 agtgggaacc tgtgtttgtc tagatctctg acatactcag tgctttttgt acccagggaa 900 atagaggcat gggggacaga gtgggctagg ctgtgtgtga aaatttttcc taattatctg 960 ccacctggag cattgcttac tgtaggacag cagcctatga catcggcatc cacaaaccag 1020 tgcttccttt ttccctccca ggaaacccac tgggggaagg gtgaggacac agaagcctgt 1080 gtcccctctg tccaccaggt aaagagtgtg tggagcgtgt tgtattggac agttcttgtt 1140 tgtcatcatt tttcttaggg aagagctcaa actcagggag ggagggagta ggaaaagcag 1200 agtggcgggt catggtggct catgcctata attccagcac tttgggaggc caactcaggc 1260 agatcacaag aggcaaggag ttctagacca gcctgggcaa catggtgaaa ctccatctct 1320 actaaaaata caaaaactag ccaggtgtgc tggtgggtgc ctgtagtccc acctactcgg 1380 gaggctgagg tgagaggatg gcttgagccc aggaaacaga ggttgcaatg agctgagatc 1440 atgccactgc actctagcct gggcgacaga gctggaccct gtctcaaaaa gaaagaaaag 1500 aaaagaaaaa cttgtctttt aagatttagg aattgaataa gtagaaattc agtgaccaca 1560 gatggaatgc tttgccagat attctctgtg tgaccttggg taggtcactt caccacatag 1620 agaaatttac aaatttcctt tgtcaaatct gatgatggtt ctaaatggtt ctctgagtcc 1680 ctcctagcca taaggtgctg tgaatgtaat gaatatcaat ttaaaggcat ttgtcacaaa 1740 aacaacgtga gctgctgtca tcttacatcc tccacattta ctgcatctaa tagcttttgt 1800 ccactttcct tttggctgac ttgcctacct gggggtacta gtactggggt ggagggtagt 1860 gaaggggtgg cttagagctc ttgctgagca tggattacaa acagcccctc ctctaggtga 1920 gcagtaaaat aaatcatgat ttgttgactg cattttagga ctgaagaaag ccaagaaccc 1980 tgcccacccc actccacccc tgtacagcct ctgttttctg gagaagagat gactttggca 2040 aggtcacatg gaggagtcag gacccgatcc cagagtcctt tactgtccca tactgctgcc 2100 tctccagcca gaggcatgga gcctaaccct ggctttggga aggaatccat cctccgtgag 2160 ttggctgagg gcagaatggg aaaaatgtgg gccccatgca cagtgtggga cctaggcaag 2220 tttgtctgga gaatcacagg aggagcctgg gcctgccaag ttggatcatg ccactagggt 2280 gtcccggcgg ctggccctca tctctcctct tgcagagtca gaaaggaaat gagaaagaac 2340 ttggccccag ggctgtgtga gaggaggctc aggcagagga aggctgagaa ggcctaggtc 2400 tctaggagtt cattcctgcc tggaggacaa tcagctagtg cccagagata aggctctggt 2460 tcaccttcat gcctgaacct tagaggcaga gaataatagt aggcaagcat tagcctagtg 2520 ttctaaccaa tgcagacccc actttctcct catttgctcc cagtggcttt gaatccattg 2580 ctctgggctg tgatgtggtc tttcttttca gaccatgaag aggaccttat ttctaccaag 2640 tgtgtcttgt ttccagttaa aaacggtgca cccacacaga gtaaggagtc aaggggcccc 2700 agacaaccca tcactgcctc accttcttcc tgggcagcgg cctgtcactc agcaggctgt 2760 ggcaccccac tccaaactcc tacaggttaa ccattcattc agcaaaatct tcatcaagca 2820 actgttatgt atcaggcaac tttagatgct agagattctc tggtgaacaa aaagagacat 2880 ggtccctact cccatggagc ttacagtcta gtgagggaag ggtggaggag ggaattatca 2940 ctcatgccag tacacagaca attgcaaact gtgataaact acccaaagca aaggaaccac 3000 agaagattct ggcactatat ggaaggtggg gccttctagg tggcagatgt aaagactggg 3060 gcccagaggg aaagcagcag gggctgtgga gaggaacaga gggacctgca ggaagctgtc 3120 ataggatgcc ttccttggag gccaaggact ggggcctttt tcctaattgc aacaacggga 3180 cattggatgt gcattttaca aatcgctccc tggctgctgt gtgcctggag aatggatttc 3240 agcagggcag aaaggatgcc gaaaaaccag tcactgaggt cctggtgaga gatgatggtc 3300 atatagaagc caggctcaag ggaagcatcc ctgcacccct ctttctgtct ctgatgaagt 3360 acctatgtga tttttaaaaa tcgggggctg ctggggggct actgacagag gagacatctt 3420 catccatctc tctgtgagat gccttcctga gccttgcgcc cagagaatcc cacttgttcc 3480 tccacttcag cacatatgaa aaatctcagc tctgtttccc aacctgcacg agcacattta 3540 tccaagtcaa aaatcatctg cgatccttct gcccactctc ccagcccctg cccaggcggc 3600 tggcccctcc tggggtttct cacaaccctc cctgccttta ttcctgaagt gcttgaacat 3660 tgcctgcagt tacactccat ttagacatta ttttgatgat aaaattatgt cttcccccct 3720 actgctcatt gtcttctgca gaatatagga gaataaggtg gtggtgtctc ctgagggctt 3780 ttcccccctt ttaaataatt ctatacctac ccccctcccc acactcattt gaatcatcaa 3840 attgattatt atccctgtgg ctggtgcatc tcaaaagatg aaaaacccag aagcagggct 3900 ggggcatgac ttacagctca ttttggtaca gtggcatccc ataatattcg ggttcactga 3960 gggagcagcg gacggggatg caggtgcgtt tgtagctggg gattcaggtg tgtatttcaa 4020 agtgtgtact tgtgccttgg agtggatgtg gcgggtaagt tgatcatttt caccacgatt 4080 gtattttcct aagcagacag gaatttattt gctcatgtct gtgtcctggg tacatttcag 4140 agagctgcca atgactagag catcacttca tacattgaga gaacgtttta tagatgcgca 4200 ccctgcatct agccatatga gagtggtgca gaactgactg gcccaggtga tgagaactgg 4260 gaagggaatc tgtttctctc ctgccttctt gctgtgcctc acctgctggc ctgacccttt 4320 gcacttttgc gcacacagcg cagggtttga ggctgcctct tctctttggt gcgtgggtgg 4380 agaaatgtga ctcattttta atttggaaaa cagatccatt ccagaaaggc tgagaggtga 4440 gtttgctaga cctgccagtt aaaagatggg ataggggtgg cccggggggt atgtaagcaa 4500 taaatctccc cccaccccag acccacctgg cggttggaca ttccccccca ccccccttta 4560 actgcgagaa ggcaggcctt agggctctaa cacccagtac tcctactgct caggaggtgg 4620 ggacctcgcg cgctgagcgt ctcattccat gaagtctctc tgtctcaccc cctcccccca 4680 ccccagcttg attctgtcac tttaagtcca gcccctgaga gatagccaat aggagccaaa 4740 ctatacatca gtctcccagc cttaaagcta cagtagggtt agtgggctcc aagtctcttg 4800 tgccccagcc tcctccacgg cttcgcatcc cctctgcccg ctctctccgg agcgtgcgga 4860 tgagtggaga gctgggctgt gcgcgcacgg ctctctgcct ccctctcccc cgccgcggcc 4920 gcctcctccc actctgcgtt ctcgcgctca ctgtgccctg cccgggctcg caccttgccc 4980 gtgcccttca ctcgctcttc cgcgtgattt ccccgccgtc tttctctacc aactgggaat 5040 gctaaaacgg gactgatgga cgtgtccgaa ctctgcatcc cggaccccct cggctaccac 5100 aaccagtagg tgccctgctt ctcggtctgt ctgtccttct gcccgtctgg cagtctctgt 5160 cctggggatc gcagttcctt ttctgcacat tcttgtgtaa aagtggaagg gacttcgggg 5220 gggcacttgg gggacgaagg aggggaaaag ccgcacactt ctgggtttct ttctagggca 5280 taaaccctcc tctaactttt tcccgcaccc ccttttacaa atccacactt tcaggcaaga 5340 gtggcgcttt ctcatgcact ttctcccttt ctctctcctc tctgatcttg ctccggggtg 5400 agaaaatatt tgagtttttg tggaatggag caagaaggga ggcagaagcc cagaacaggt 5460 gcagggatgt ggttgcaagg atgtcctgtc ccgtcagaga aagcctttcc cgcgggcgct 5520 ttgttttatt atttccatcc tggggaccaa aaatgatccc ggcaagagag agaaaatcga 5580 acgtgccgcg gcggtttgga aactgcaggc ggccagtgcc gctctcgcct cgcggtctcc 5640 gtggggcgcc ccgagggtgc gcacgtggcg cggcggatcc agggcgcccg ggggatgcgg 5700 gcccagcgct gcgtcgtagg caaagttcgt tctcggcttt gggggaggct gtgaccagcg 5760 gaacagaagg gcaccatttc cctgctccga ggcggctttg cgctcgcggt gccagaacct 5820 ggggttatcc gagcggcgtg ggcgcgggcg gcagccggcg ccgcgagaag cgactctcag 5880 aaaccgcggg tctccagccc cggggcagcg cgccaagagc gcagagtggg aaagtgaact 5940 gatcgcctaa gcagcgggtg gtcaacccgc gtgtcatgtc cgggctctcg gggatcccac 6000 tctatccacc tacggtttcc ctcccgacac cctccacggt cgccgctcca cctgctcggg 6060 tacctgcccg ggtctcccct tgggcgctgc gcaccccacg gcgccccccgg cgggtgtccc 6120 ggaggcaggt tgtgtgcgcg tgcaaagtgg tccctcggaa ggcttaataa taataataca 6180 taaaactcta ggttcttacg gacagctttc ctgcttaact ttgtgctcgt cttcctcttt 6240 tttttctgac gcaaactaaa ttctccaagt cagcgtttct ccagttccac cgtgctttca 6300 tttgtgtacc actcgctctc cccctccccc caagaaccac gactacatct ctaaaataaa 6360 tactctggat catgtggggt cccaggaagt acctaacccc tctcctggct gcatggagca 6420 cctccaccac ggtgcacccc gcttgagaga gagggcagct gtccacagca tggcttgtgt 6480 tgttgaccag actgttcctg cttctagttt ggggattttc cccactccac cctggggcag 6540 agggcctttt agatgccacc agaatgtcgg cagaaggcgc tggtctggga gaggaatcct 6600 taataataat ggattccgat ttccatcagc ttgaaaagtg gctttcattc cttttaaagg 6660 ttagattcta gctggggtgg ggatggggtg ggagcacctg aggttagtga ggctgtggac 6720 agtatttggt gcttgtggag catttcctta cataaaatga tcaagtatga caaatattgg 6780 atatttaaat tattaaggct ccctctctcc agaggtgact tctttagttg agcacgaaat 6840 acttatgtat ttgtccctgg ctcaagtcat agtcaataaa tatgaaaatt cgtatgaagg 6900 aagtacattc tttgattatg cttaccagga aagcaaggag tgagatggag gctttaacag 6960 ctgggtaatt catcgagttg acggcagccc tgactggagt ttgaggagaa atatgggcaa 7020 aaaggcaatg tcagggaagc agcagaagga agtcagggag ctgaggtcct gggggtctgg 7080 gaaaggtttg agatagaaat catttataaa ctaagcctga cagaggttta gatccccaac 7140 cctttccggt tttttttttgc aaagaattag cttgtccctc catggggcac aggaaaagcc 7200 aaaaatatac ctgctgtctc caccgaggaa ttgagcaccc ctgtcagatg tcatttctca 7260 aagcccagga cccactgggc agcagcccag gcattgatga gctggcctct tatacatata 7320 tgtgccgcct agggagggtc tgcatgtgct gtggcgcaga ggggcatcat ttcaaggacg 7380 agcttgtgga ggtctggggc tggtgtctgg ggagacatct ttctgacctc taccccatgg 7440 ctttgtgaca cagctttaga gccatgggta gtaaagtaac agagcagggg actggattct 7500 ttggtttggt agaaggatag taggacaaag ccattcatta tagtgccggc atttcccagg 7560 gaacatacag taagtgggtt cgtgtatgct ctgctcactg ttttgacccc tgtggattgg 7620 ctgacattcc cagacttgag aaaacccaag ggcacaggga ctagagttga gggaggagga 7680 actctctggt cctccctttt gcttctaaca catagagagc atttgttaat gctgtagaat 7740 cattctcact ttcccaggtg agaaatgaac acacacagag agaaacatac gtaccttcct 7800 accttgctct ccttcatttt cattttcctg tagccaatcc tgtaggtgac tccattaccc 7860 attctaatca atattttatg tacatatata atcacccaga gtgggaggca gcgtgctcgc 7920 ctgtgtgtgc ctgtgtacaa atgggtccat gactggacca gctggagacc cacggcaaac 7980 agtccagaga gcaaggggggg ctatcttccc caccgtccga tgaccacttt gctgttgtta 8040 aagaaacaaa gaacaaattg tcctgaaggt aaaatatgtg ggttcacacg taggaaaaat 8100 gccacatggt aattcagagt cagtgacccg gagaaaaaca aagggggaaa ttaattttta 8160 atggtacatt taaaaataaa tcagagtgag gacatcagtc tcggttttcc aagggagggg 8220 ctctaggaaa taaaccttta tgtgcctgtc agccttctgg aggtgtgcgc tgccatggaa 8280 gaggatgggt gataggaggt gggaggtgtt caggcctgaa ggcgatgaac tgggaggaga 8340 cattaggtca acgctggagg gccccggtcc cgggtaaggc cctttccagc tcagtgagat 8400 cctgacatca ctggaaattt cctcttggag tttgttactt cccccaaccc ttttcatttt 8460 agaaacaatc ctttattttg ctgataatga ggacatatga aaaagatctg ttccaaaaaa 8520 aaaaaaaaaa agcacagaga aacaacctgg ccacaaaaca ggaatctttt tattctattg 8580 atttggagta atcaataaat attccattta gtctgggaga ggaggggcag aggggacttt 8640 cggggaaagc acttcaaagg aggtggcggt gacagagatt tcatgtcaca ccctgccttc 8700 tcagagcacc cctggcccta gctcgggggc ccttataact ttgtcctgcg tgtgctccat 8760 tcatattcct gataactgga cattttgcca agtggttttt aaagataatc taaactcatt 8820 gagaaagttt gtccccttcc tcagccctct gctgaatgcc ttgtttcttt tgagcaaaga 8880 tctgcctact tctgatgggc cggaggaagg atgcgtgtga cagagagaca ttgagggagc 8940 atgtacattg gggagggcgg tggagttggc catgaatgca taggattcag aaggagacag 9000 aattcgaaga cagtagacaa gcaagaaaca ggatgctttt ggcctgactc tgcagcgccc 9060 ttctctagaa cttgtctccc caagtccttt aagcgacttc ttaaaaatga ttaaaattct 9120 ttttggttcc aaatttaagg gaagagatag cagatattta gaccataatg tcctccttca 9180 aagtaaagcc cacaccacac cttgactgcc tccattctgg tgttccccaa cacctaccgg 9240 ccatcatcga gtctctgtcc atttctttct gaagtgagac cctcgtaatg ctcttcctgc 9300 tgagcaggag ctctgcccag aattagcgag gatgccgcac agctcccctg ggagcttctg 9360 tcgtagagtc tggtggctct tgactgaatg ttactggggt ggggagcccc agcttgactt 9420 gaatgttcaa cctctggggt cctccagtga cactacagcc cctagaggtg ctgccagtgc 9480 agggtctaag gaaggacccc aggaagccag gagagtacaa attaagaatg ggctggaact 9540 agccaaatct ggcccggaat cttcctgaac atcctgcctg tttgcccttg aaggctttca 9600 ccgatttcta gagataaatc aaagacgttt ttagcatgta tgcactggtg acccctgatt 9660 ggtctctgtc tctggtgagt ttccccttcc tcagccccag cagccttaga cctctgggga 9720 cagtcacaga catggtcttc cctcagagga gaggcccata ggctttgggt ggccctgatg 9780 tcccctgtcc cctggcatgg gtggggtggg attatatcct tttagccccg tcagctggta 9840 tggcttcgtc cctgcgcggg gaggttgtgg tgtttataat tgcaaatgta attagcagac 9900 cagctctggg ggactgggag gctcaacttc tctgcacttc acggtgaccc ctgtaatggc 9960 tggcccggca gattaaccct caccgggcca gcctgcctcc tgccactggt gaggctgctg 10020 accttctcta ataatggcag ggctgtcctg ggaccagaca ccttccgtgg aggggttgtc 10080 agggcaatga ctgggagaga tccgtagttg ggaggatttt ttcttcccca gggcactggg 10140 ctagtgacct ttgcctcttg agacactgtc accctgggca gcaggctgtg ctgggccatt 10200 tcttctctcg tgttcctggc catactggaa ggatgtgacg gaaggactgt gagtgcatgc 10260 tggtcagttc tgtggctcta aagggactca ttgtgacttc catctggtgc tcctgggctc 10320 agcgggcagt agcttgtatt cacccatctc atcagcttct tctcagagcc agctttgggg 10380 aggtgactgt tcgctggctc ctggactctg agcaggtgtt ccacagagct ggactgcttt 10440 gggtagggag cctggtcata ggagagcaca ggctcaattt gtttctgaga acagagacct 10500 caccagttaa ccatccaaca aaaggacaca aaaacaccag acaagtgggg aacatggagc 10560 tgcacggtct tttccctccc tcctatgagt gtacttgtat ttgcctctct aaggtgccct 10620 tctgtactga tcaggattaa tatcatcaag ggtcctaaca ggacctttct ttataagtca 10680 ttgcttaaca gagtgtcaag cccttctgtg ctgccaataa agcccctgtt gtagaggatg 10740 tttctgaacc tcgaaacatc aaaagccgtg tccaccccaa gagagtttcc accgtgggaa 10800 acctgtgtgt gcacatgtgt gaatgtgttc cggtgggtag tcccctttaa gatggggtga 10860 cagtggacag gggtctctgc tatttaaaca tgttcctgct gactgctata ccccttggct 10920 gggctgaggt ctggctgtga ccacattcca gcaggggctg ccgtgccttg ggattggttc 10980 gtccatggtg caaaggggac tgcaggggca cctgctaggt ggctgtccct ctggtttgcc 11040 cagaggattt cagtcttaag agcctctctg caattttctg gcctgggtag gggtggggca 11100 gaccccagag agggagagaa ggaagtcctg cccttctcca ggataacaga tggccacact 11160 cagaggagaa tttgggccat tctgttccag gttcccgact tccccttctc tccctggaaa 11220 tagccattga caggttgtgg cttaaagagt caactctttt cttaaatcaa ggaaaatcat 11280 actggttaat cagcccatgg gatgttcact atggagttgg actaggtgga aaaaaattat 11340 tggccaaatg ttttaaattc agaattgtct gagtttgagt taaaattgta taaatctaaa 11400 acaaaagttt tcctggggct cagagataga attttttcat ttcattttgc tgtgctttta 11460 aacctataca cattttggtc tgaaagtttc ttttttaaaa aaaaaatgtc tttcctttgt 11520 tccttaggac tttaaaatac tctattcaat attgtcattc agcatccccg ggactgaacc 11580 ttttcaggga atggttttct ggaaaatttt attatatttc tcaatgtcat ttcattcaga 11640 ggtcagaagg cagttaaaca aactccaaca agcctttgtt tttatcttct gatttcaaat 11700 gtgatcaatt tttatttaaa atcgtatcag agacctctcc taccaattat aggggcagtc 11760 agccttgtgc ctgaccattg gtgtttacca aaatcctgca tttaaaactg tacgaatgtg 11820 aagtgtcaaa ttgaattcaa tcttttctat caaggaaacg atgagtttaa aaaccccaaa 11880 taccaaatgt ggttttaact tggttctttt atttttaatg gcttgaattg gcttgagttc 11940 ataaattagt ttttatgttt tattcttttt gttaattcat tttgaaattt ttattggttt 12000 tttttttggc attttcatct ggcttatgct ttaaaaatga tgcctgataa agggtctttg 12060 agaatcattg gccttttgat gtgttcttgg tttctgaagg gcaaagaaca aggaaataca 12120 ggtgtaagga aatgctatag gagaggatgg aaggggtgaa gaagcgtgat cttttagatg 12180 agatttctct cgtgttttac aatttagcat tttcctttgt cttcattttt tcccctctat 12240 ttttattcca gcttgctgta gtttgccctt gtccttttgt ccctccttga ctgttttgga 12300 ggaaggagtg taggtgtgtg gtctgcctga gtgtgagtgt gtgtgtgtct gtatggctgg 12360 ctgagctgtt cagaggtgct gagcatgatt agttgggtaa agtcccaaag cagaatgcct 12420 ataattggcc cccctgttct gattcagcca tcaatacctt tattcatggc cgctggctgg 12480 ctcacgtttt ggtgaaaaaa acaagaaggg tgtagacctg ctgtttacag acaaatttca 12540 ggtggtctgt ttgttatctg aggcgcgtgg tgataggggc tgcaggtatg ggtgaggata 12600 tgaagaagca ctaaacttta tgcaaaacca atttttaaat ccctcccctc atctcaccgc 12660 ctatgcttgg aaccctagtt tgggatcttg gtgatgcaca gtaaatgagc tgttgtatgc 12720 ttttgttttt gtcttcctaa tcgatcagca gaaaacattt ccttttgatg gtgaaacagg 12780 acttcagcat gcagagcgca gtatttatcc tcttactttt agcttcactc tttgtcattt 12840 gtctcttggg tttgttgaca ttgtctacct aagcagtcaa gctaacaagc tttggcagaa 12900 agaacactgc ttttacagaa atagtagcaa ttttaatgtg atggttataa taattgtgat 12960 tacagtaatc acagcttgta cctttttctt cccaaaaagc gcaaagcaat tctcgtaacc 13020 atttttctca tagtagctgg atgagggtga ccgtttcttg ctcccaaaca taaatatctt 13080 cgtgcaaaca taaacatgca aaggctgcag gtttgcgtgt ctgaattcac ccaggagcaa 13140 aaactgcctg gtctctgaat acgaacaggc aggtagagga gaatacggtg ttaaccacct 13200 ggcccccctg agaaaagctg ggtgctttgc ctttgaacga agatgggaga agtgtttctt 13260 gtaagtgatg ctgtgccaag tttgacccca ctactgccgg cttctatgcc ccgtgccatg 13320 ctctgcctcc cagtttcccc ttgctccttg gttcctctgg ctgcattctc atgacaggtt 13380 tgcagaccaa aggcacagag aggacaaggg ggggttatga cttggcgcat gtgaatatct 13440 gggagaagaa ctgtgtgaag agagaggcaa agtcatctct ccacccttga tcgccttctt 13500 ggccatttgg cttctatgag gccgttgtcc ctgctcctga gtacctcaac ctgcactatg 13560 gaggtgatta gagggaggtc atcagggaac tgacctctct gaatttccat gtcccttctt 13620 gtgatgcttc atggcgactc ccagacctga agcctgctca cctacagacc atgctcatct 13680 gtgcgttact ttagaatcca tcaatgcttc tgttatttcc tctctcattt ccttttttgt 13740 atatgtatcg tggaacgaag aagcagctct gcttcaccta atattccagg gtcccatagc 13800 tgtctgtatt ttttttccat ctcaatattc ttattcatgt tcttactcat agtttctttt 13860 cctcaggaaa aaaaaaaaaa aacaaccaaa cctcaaagct ttggattatt aattgattat 13920 taactgattt tacaaacaaa tcattccacc cccaaggaat gcaagcaaga ctctggctgt 13980 gctgcttagg ttgagatctg ctttccccct caatcggtga gaaattttat atcttcaatt 14040 cccttgttgg accctgagta aaaaattaat tcatgaataa taaaaaccaa tcagtcttgt 14100 tgagtttaag aaggattagg agaaagggtg ttttttctta cagagaacat ttggaatctg 14160 tgtgtcactg tcaccgagtg tttgggggtg gcttgagcga tgcctttatt catggcaaat 14220 gagctgttga ttatcctgag tataacacat cttcctcagt tgttaaggcc agcttactgc 14280 tgactgttac ggggttccta cccactgctc tccccaccatc ccgtactcca agccagtgat 14340 aattcactga aattaagaca gtttcctgtg taagtggcat ataaccaaat agcaactgac 14400 ctggcctttg cattatgaat aagcccattt gttgatggga tggagtcctt cttggtttcc 14460 ctcccctttc tttctcagga agtaattgac cagaaattta catgcttttc ccagaactac 14520 agaaattaga tgtgtagatt ctcttttcag tttccactaa tagtatctac ctcccagggt 14580 tgttttgaag atttagtcag aggacaagca ccaggcatat agtaggtgtg cattaaatgt 14640 ccagtgttat taattttttg atgttatctt tggggcatta ctttttattc ctttgacata 14700 atctcacaat tatagtcttc cctacagtga gactggggtg cttgaactga ctactttgtt 14760 taatgtgatc aatatggctc gcgtgtcaat atgtaacaca aggggattaa agaaggaatt 14820 acagtttggg atggagagga tgaataggaa attttcctct gaacgaatcc ctatattttc 14880 agtagggctg tccagtaaaa tacaggatac ccagttaaat gtgaatttta cataaatgtg 14940 agtatctttt tttgtataag taaatcctat gcaatgcttg ttaaatctgg caaccctatc 15000 tacccatgac tgtttttctt aaaatagtct gataagaaac acattgctct tatttttttt 15060 ctgcttttga ccaagcccga aagattaatt ctaggttcgg ttttttaatt tttttttttt 15120 ttttttttgc gacagagtct cactctgtca cccagtctgg agtgcagtga cacgatctcg 15180 gctcactgta acctctgcct cccgggttca agcgattctc ctgcctcagc ctcctgagta 15240 gctgggacta caggtgtgtg ccaccacacc tgggtactaa ttattttgta tttttagtag 15300 agacggggtt tcaccatgtt ggccaggttg gtctcaaact cctgacttca ggtgatctgc 15360 ctgcctctgc ctccaaatga ccatctttaa cattttacca atatgaatgt gttaggctgg 15420 ccgtgccctt agatatggca gtgggtaagt tccctcgacc agatatattg atagagttac 15480 aattaagtaa ataaatctgc tgaatgaggt ctcctaacag cacccagggc tactgaattt 15540 tgccttaggg aggaacaggg taagtcaagt ctttttggga acctgtctgt gcctgatgtt 15600 tccctgacaa acgggttggg gtgctggact gccagaacct gagaccccag aaactggaag 15660 ttacccttgc cccaccctgg aggccaaagc agcagctctc cctacctccc cacacaagga 15720 caggaggctg acccttgtga gggtctccca ggaggctgag gggaagcagc ccaaatcagt 15780 gttaggtggt ggatcaggga gggttaggac tccaaacctg aagcagagct agttgagagc 15840 atggatgaac cgggtctcgc caacagggta ccagcggacc ccagcttccc ctcattcacc 15900 tctcagaaca gcacagtcgc acagccttgg taaacacaac cattgtttta agcctgatgc 15960 cctcacagcc ccgggtacgg ggaatggaag agctctagag ccccctacag gcactcactg 16020 gcactgcacc ccatgggtga cagttctgca acagagcctt cccttggtgg ggtgtatgga 16080 gaatcccagg gggtgagcct tcagaagctc aggggtgagc tcaggaccct ggctttagaa 16140 agcagctctg gttttcacct ttccgagccc tgctccatgc aatttagcac tgcagctgcc 16200 ttgtagtgtg gtattcctcc caagccccac catgcatgca tgcacaccta cacaccacac 16260 actcactgcc tccgtggctt gcctgacctc cagacgggct ggaaagtgct caggtctgat 16320 tcagtttgag gaatgacctc cagctgctga atatgcagaa gccgtgcagc cagcaccatt 16380 ttcagagcca gatactggtg ttcagatgct cttctccaag ccacctaatt ctctggggaa 16440 tcattttagg atttgatgta agaaaagtgt ctgagggggg ataggagagc taaatataaa 16500 gtgtaaggcc agagatgggc gattgtaata gtaatagttg tagtaattga catttattga 16560 gcatttactg tgtgtcaggc tttgtcctaa gaatatttca tgtatgaaat catcacttcc 16620 tcacaacaat cctaggaagt aggtattatt atcatccccc atttcacagg taaagaaact 16680 gaggtacaga gacgttaagt catttgccca aggtcacaca gctgacaaag ctgggatttg 16740 cacagaggct gtctgggtgt gtgcctgcac tcctcacccc gatgttatgt gtcgctcatt 16800 gcatctagaa tttcagcttt ctttcattct tttttttttt tttttttttt gagatggagt 16860 ctcactctgt ggcccaggct ggagtgcagt ggcgcaatct cggctcactg cgcgctctgc 16920 ctcccaggtt cacgccgttc tcctgcctcg gcctcccaag tagctgggac tataggcgcc 16980 tgccaccatg cctggctaat tttttgtatt tttagtagag aaggggcttc actgttcatc 17040 ctgttagcca ggatggttct gatctcctga cctcgtgatc catctgcctc agcctcccaa 17100 agtgctggga ttacaggcgt gagccactgc acccggccta gaatttcagc tttctaactc 17160 ctgccttcag aacaccttgt gtagatctaa cacttgggca aagtttaagg tggtggtgga 17220 gggggaaaag accaagccc atgtcttggt tctgaaaaaa ataaggtgga agaattgctg 17280 cacagagtca gacctctcat cccccaggtc agcttccatc cttgtcctcg gcacaggaga 17340 aagctgtagg aaggaacttt tggtcttcct gacatcatcg tccaagggcc catgcccagc 17400 ctctggaggc cactcagtgg tttgaccccc tccatgcctc tcctagagtc tatcataaac 17460 atattttgaa gccgacttcc ctcttctcag cttgcatttt ctcctgttcc ttgccttccc 17520 atcattctct tatcgcccat tctccaacag ctcccaagtc tgagtctcag tgccctacct 17580 tggtgcccgt cttggattcc cgcaggcacc acacagcagc acgtgcaaaa tcaaagacag 17640 catcacactc taaacctgct tatcctcatg tctctttagg caggcacccc ccaccaagcc 17700 aagatatgga gcgtatcttc agttcttccc tcctgctctt cattgttgag tcccctccta 17760 catctggaaa acttttacct atgtatacac ctcagatcta gtcattcttg tattgcttcc 17820 cccaaccctg gtctgcttag caaacttcta tttatccttt aaaaccctgc tcaggtatcc 17880 ccctctgtgt ggaggcatcc ctgacttctc cctgggggaa ttagtctttc tccttgcagc 17940 tgttctctgt ctcatgcccc tgactggttt acaatctgtt ggatttgaat atttgcttat 18000 tttttctcct agatcatgag gtcctagagt ccaaggtcat ctctgtgtcc ccagtgacac 18060 agagtgggtg tttaataaat gttggttgag ctaacctgag gggattggaa gtagttaaag 18120 gggagccctt gggggaaaag aggcagaaag aagggcctgg gaagaggtaa ccaggagagc 18180 actggttctg ccacattttt gccctggttg agccatggag gcagctctgg cttggggagc 18240 attatatcct tctgggaggc aatgcagtgt tggggttaag agggaaaacc ctagctccag 18300 actaactgaa ttgaaatcct ggtcccaatg gtgtgctgga accagctcaa accagctcag 18360 gagagctcac tgttaaatat tcagcagttt tgtgggctga tggtcaaaca caatcattat 18420 taaaaattaa atggtataaa cttataatta aatacattgt attaaaaaca aaggtaatag 18480 ataccactcc tcacttcctc atatcttagt acattcact ttacgttctt gccatcaatt 18540 tacacctaat gtatggtgga aaaaccatgc gatgctgagc tgctgcctgt ctcttcccaa 18600 gcctgcattc catgatgaca cactggtagt ttgagaacag ccatgatggg agtatttaca 18660 ccacggaaat tggcaaatgc tacagatccg ccgtccccca gctggccatt aaacatttat 18720 taccacacca ctgcactggc tccgtcacat cccagctctg tgaccccaga taaatgactc 18780 aatctctctg tatctcagat tcctcttctg ctgtgatctt ccacgttaga ttgctgtaaa 18840 gattaaaagt tgataaacat ggctgagtgc ggtggctcac gcctgtaatc ccagcacttt 18900 gggaggctga ggtgggcaga tcatttgagg tcagcagttt gagaccagcc tggccaacat 18960 ggtgaaaccc catctctatt aaaaatacaa aaatcagcca ggcgtggtgg tgggcacctg 19020 taatcccacc tccttgggag gctgaggcag gaggatcact tgaacccagg aggtggagat 19080 tgcaatgagc caagattgcg ccactgcact ccagcctgga aaataaagca agactcagtc 19140 tcaaaaaaac aaaaacaaac aaacaaaaaa agataaatat aaggtactta tagcagaaac 19200 tagtacacag taggtgctca ataaatatta gttcttttta gtatttcttc tcattgctcc 19260 agtgatgccc ctatccaaat tctacggaaa cagatgacgt gccaggtaga ggaatgtaag 19320 ttttatttct agagcataag gttcatgtcc tttccctaca ggacccctgt gcgtagggtt 19380 taacttgagg agctaagtgc gggaagtaaa aaccatgaat tttccaaggg gaaaggcgct 19440 gatggagagg tatgctgaag cctccaggcc atgagaggat tgtgccccag gccctttgag 19500 gaaatgaggc cacagcagca catggttgaa caggtgaggc aggcacaggt gaggtcagga 19560 gaggaatgaa gcagatgcca agaacagcca agctgcagca tgaagggagg ctctgtgtgt 1920 ggctgcagcg gggccccagg accttgcgag gaggcagctg ccctctctgg aaatgctggg 1980 ctgtgcggtc atgcccatga aagcaagggc tcctctggct ttggaagtgg agaaaatatt 197440 cctggccaat cccgagttgg atcacacagt tgaggttaca ttggctgcat tgtggtttct 1800 tgggatgcta caggaaagcg ggaaggtaag atttggtctg cagcctccag gacagcagag 19860 gccaggaaag agcaagagtg cgtttgggct tttctagact cctccgtggc aggtttcctg 19920 ggtcccagcc aacccaggcc cctggaatga ggattcacac ttaatctctc tgttacctgg 19980 aaattgcttc aggttcagac ctttgccatc aggaggggca gttcagtgac tcagatacac 20040 acagttccca gcccagccct tttccgatgg caagtgcact acaagcccac agaccgctgg 20100 caatgcgtac atctgcatgc tgtacaggcc agaagctgca gctcattgct ggggtctgct 20160 tctgttcttt gaatccctgg tctgtagaca aatgcccttt ggagcggcct tgccgaggag 20220 aaggcagcgt tgagagtgaa gcccttcctt cccacctcac tatgggagtc tttcacttta 20280 ccctgagctc ctcaagggcc catctggttc tgattcgtct gcagcacaga gtcagtcatg 20340 gaggagcctt cagtaaatgt gaggtagaag tttagataca ttttgagaaa atttgtgctt 20400 tggggtgcac cactagtggg ttacctgttc agttgtacag gttgttcact gtccaagagt 20460 gcctggttga ggaggtgggt ggggtctgaa cttagttttt ctaattcaca acaagccaca 20520 catagctggg gcatgggggt gagtatccaa ggggttgagg gcctagaggg gcctgaggaa 20580 ccaccttgcc aggctccaac tcattcattg ggagcaactt cctgtctaac ctgtgtctgg 20640 attctctgaa gaactctgtg tttctttctg ctggcaacat ccctgcagcc tgcatttaga 20700 gccggatagc tcttcgaagg ctttctgttc tgtgtaactg cagtacttag cgggtccccc 20760 atggctctca gcaggccccg gggcagggag gggcctccag gcgctgccct ggctgctgat 20820 atttcaagat gccagtggaa gcagagacac tgcggccctg tgttcccaga gtcaaggtgc 20880 agggtggcgt gtgggtatga gtaagccagc agccctggca ggcaggggca tatccgagaa 20940 acagtgtcac agggttcctg ggctctaagg gcctctgtga gtagattttt gggagtgcta 21000 gaatttatca acttggaggg gaaggaagct gctgttttag catttgatgc ctttaatctt 21060 tacagtaata cctacgtagg gagtcctgtc ccccgtttac agaggtccag aggagctgag 21120 tgactgccca aggtggcgca gtggatccac ttgaagagcc aggatgcatg tccaagtctg 21180 tctgcctgaa acagctcaga attccagggg cccagaaaac ccactgtttc tatcacagat 21240 ctctgtcttg ccaggcccac cctcctgatg ttttccccaa cacattaatg tggtctcagg 21300 cagaactact cagctgaccc tgggctcagg aaaggggagc gcagaccctg agacaggcat 21360 gtggctcggg ggctgccacc agggcctcat cccagtatgg ctgtggagag ggtcaggaca 21420 tctggaagag ccagtgttgg gatctgttca tgctgtgcca agagaagtgc ttccatttgc 21480 caagaaagaa tgaggaagag ggaagggcag gcccacctcc ttgctgctcc ctgggtcagt 21540 agccctgggt ggccactggc cttcacagag aagagccact tgggggtggt ccacatgtgt 21600 gagctggaac ccagggcctg tggccagccc tgggagggcc tctgtgcggg catgtggggc 21660 agggaggcac tggaggccag tttcctgtgc aaagcctttg gggcatagcg gatctggggc 21720 atagcagaga aggaggcctg ctttggtctg taaggtgctg tagccaggat ctaacacacc 21780 tggacttggg tttgtgggtt tatctccctt gtgtattctt tgaccaccca gctccatgcc 21840 tggccagcag agttctcgca ggagaccctg taggcttgtt gtgaggccat agttggaaac 21900 ctgatgggcc ctccctagag acctattgcc tggagaagtg ctccctccgt agctccagta 21960 gacgccccta cttgcagtct tgcccaccac cttgctctca acactcctct ccatgccctg 22020 cagcctccta agactttcct ctgtgccagc tacttttgca tggcaacaat agtaataaaa 22080 atagttacat atggtcaggc aatggatctg ttttttggtc tataagtgta ttttatgtta 22140 aaaattttac attttatgac ttcaagactt tgcatgaaat acctttactg caaagaagaa 22200 aacattacct gggatcagag cagtcacaga acacagaggc ccctggcagt caggagagag 22260 gtcccctggt cggtgcccag gtggagagtg tggccaggtg ccggcaactg caagtgtttc 22320 caagcaggtg cccatgtcca gcagatgcct gcaagacttg aatcagaggc actgttctga 22380 gggcggaagg acctggggtc cccaggctgg ccgaggcaag ggactccacg gctgctgtct 22440 tctcagtaag aacaccttgg attctttttt ttgagacaga gtctcgttct gtcacccagg 22500 ctggagtgca gtggcacgag ctcagcacac tgcaaacttc acctcccagg ttcaagcgaa 22560 tctcctgcct cagcctccca agtagctggg attacaggca tgcaccaaca tgcctggcta 22620 attttttttt tttttttttt tgtattttta gtagagtttc accacactgg ccaggctggt 22680 ctgacctcag gtgatctacc ctcctcagcc tcccaaaatg ctggtattac aggcgtgagc 22740 caccgtgccc agcctagaac actttggatt ctaattttag tacttccagc tcctggccat 22800 gtggatgaga tcagagattg tgcctgtgtc aggtagactt ggccactcca ggcaaaacca 22860 gcttctcttt gatgctgggc tcttttcttt tcccccatcc ttctttcttt ctagccctgt 22920 ttccctgcct ctgtcgttct aggccagttt ccctctattt ttctctttgc tgatgctcac 22980 gacaatagta atatttgcta acatcttctg actgcccact atgagccagg cgctgtgcaa 23040 agtgcatctt gtggctactc atatgttttg cctccttccc tctttctggg ccttttgtac 23100 tgaagattca cctggtatcc cttgagcacc tcatgtggct ggtactctcc tccccaaaga 23160 ggatgcagcc ttgtgggggc tgggagggag cctcatttgc tccagcgccc tcattttaca 23220 gaagagaaaa ctgagggctt gagctgatga gggccttggc tacagttctg cagcttgggt 23280 gcagaaggaa agccagggct tggcctcttg acctttaccc agagctgtct tgcatcttgt 23340 ggatgcaaat tgtttgctgt cagctgcgtt gagggcctct ttgaccttgg ggttctgagt 23400 acctaaatgg tgagcctcgg gccaggcagt gcagatcagt gatgtcactg tgccagtgtc 23460 actgcatacc cacctcaggc tgggcagggc gaggagactg caggagccac gcagagccag 23520 aggatggctg gacggactga catgaaccat tcccatgtaa gaaaattaaa agataaaaat 23580 aattttgata gagggaaaac tggtaggagg gaagatgagc tggccgtctg ggcgaggtgg 23640 cctccttcac aggttttgct gccatcatct ccctatgtgg gcccacttct ctccccgggc 23700 catccctgta ggctcttctt tgcccttggt gacctcagta ggagctctcc gtttccgaca 23760 gtcagcccct cgcccagtgg gaggaggaga tagagaggta agagctacct gagaattaag 23820 ccatgtgcac tatctggctc atgctggtct tcccggggcc tcattccatg gctggcatag 23880 aaatatgaat gcatcgtcct gctgtcaggc agcatcccag ctactccagc ctgtgtccaa 23940 ggtcagtacc taactggcca tccctgctcc gaggtcactt gagggtctgg caatattacc 24000 atggatctga acaccactgg ctccccgggg gctgcagcgg ggcgtgtgga ggaaggagtc 24060 cctccggact cacggcccac actagaagaa cataaaggaa tagacagccc ctgtgtggtg 24120 cagcagagca agcaggacct ttgatgtcag acaggtatga attcagctga caactcaact 24180 ctcccttggt gtgtaccctg gggcaagtca cctaacctcc ctgtgcacgc tggcctcatc 24240 tgaaaagtgg gaataagaat ccttctctta tagggttgca gaagaattta ataaaataat 24300 gcttgcaaaa tgcttttatg cagggtactg tcagcctcac aaaccagaga tgccccaagc 24360 attctctgta aacacggcta tgaccattca aaagaaaatt ataaattcat tttaaagtat 24420 tattaatta ggagttatta tatatttttc cacctaataa agactaaaag taccaagatt 24480 atgatacttg gtacttgggg tggggggcgg ggttgagaaa tgctttggca ttaaaaagag 24540 gccttcagcc gggcatggtg gctgacgcct gtaatctcag cactttggga agctgaggca 24600 agtggaccac aaggccaaga gttcgataca attctggcca acatggtgaa agcccgtctt 24660 tactaaaaat acaaaaacta gctgggcatg gtggtgcgtg cctgtagtcc cagctactcg 24720 ggaggctgag gcaggagaat cgcttgatcc caggaggcag aggttgcagt gaaccgagat 24780 cacgccactg cactccaacc tggtgacaga gtgagactcc gtatcaaaca aaaacaaaaa 24840 caaaaacaaa aacaaaaaac aaaaaaacag ccttcacagg ttcatgtgga ctgagataaa 24900 aatacaggca acatagagtt gagtaaaaat aaaaatcaag tagctggaca gtggatagag 24960 taaaatcaca tgtatggctt tttaagctct aaatgctggg tatatgcttt tgaaacttgg 25020 ggaaagagat attaaaaaaa actgtccttt gagttagctg tagggaatgg gcttaagaat 25080 cctggtattg ggagagattt ttacctttaa ctttgactct tttgattgta tgtacatatt 25140 ctataatgaa aacaatttta atgtgtaagt taagggaacc aagtgtgagc aaacaagcca 25200 gcaaactaat aaacctttct aagaaaaaca ttgaaataca aaggatcctt atgaaaactt 25260 ggaagtcagc tctctggaca cacagtcctc tagaaaccag gttctgtccc tgctccaggt 25320 ccctgcccac ctgctcccct ggtcccctgc agtgcacatg ctaccaagcc tgtgcctctg 25380 cctgcagcag gacaaaccca gacagaggct tagcccggag gctcaacttc cggaggctca 25440 actcccggag ccagcgctgg cggtagatgc agcagccagg ctcggcctgg gttggcaagg 25500 gttggcctca ccactagatt ctctctccac ttcacgcctc atggagccag gccgagggag 25560 tcgctggagg atcgtgacta cccgagtggg tggttgctca cctgcccagg aagccattaa 25620 tcttgtgtct ctgcggcctc tcctcccacg ccagccgccc gggcacggac tgactcggga 25680 aaggacatga aaggggccct gggcttcatt ccatggtgga ccatgaccct ggaaaatacc 25740 atctggcttt tctgtgtgtc ttctgacacc aattccccta gtcgggacac atcaaagaga 25800 gtgcgcctgg tgacatttct cattgttatt cctttggcag ggccttcgga ttcaggtcac 25860 agatagactt gcacctccag aggctgcctg tggggcctga gccccccatc ttacagatgc 25920 ctcaggaggg ggcttgtaga ggtgacccag gaccccctag cggccaagac cccagtcaac 25980 ggcacccagc aggccagtcc cccagggcca gtctgggcag cagaacctcc tggagtgacc 26040 gctctgactt tccttctctg ccctctgatg ctacccacgc aaaacagcca aagcgccagg 26100 taccccatcc agggtgtcag taatgtgtgg agtttgacct taccctggga atcccagctt 26160 cagtcacaga gtcatatttt ctttacggag gctgggcttg ctggctttaa agtaattcca 26220 aaatagattt attggacaaa atttgggcaa aaattgagac aaaataattt ggggcaggcc 26280 aggcatggtg gctcgtgctt ctaatcccag cactttgaga ggccaaggca ggaggattgt 26340 ttgagaccag gagttcgaga ccagcctggg caatgtagcg agaccttgtc tctatttttc 26400 aaaaagaata aaacatttaa aagaataata atttggggca aaaagggggc ttctgaataa 26460 cctcgaggtt tgatactcag aaatgcacta cctcctgagc agaaagtcgc ctgtggcagg 26520 aggtatgtgc atgcaaagtt gacctgtttg gaaggttata gaagatacaa cagcagccag 26580 gggcttgcac tatctgttgc acactttccc cttttgaata aacccctttg tttcatatca 26640 gtggggaaca gaggatgggc acatgcaggg cctcattgga tattctctca cttttttatg 26700 tctagccttt taaacatggg gcagtgcctc ctacgccagc ttgtgctttg ttggaaaatt 26760 ggttcaatag ccctgctagc tggcatgcat tgaagtattt cctatatgcc aggcacagtg 26820 tatcgtgcat tacccagtta gtacttttga atttcacaac tgtcctgcaa agtaggcact 26880 tgcattttcc tcatattcca gatgaggaaa taggagctca gagaggttga gtagcacccc 26940 caaagtcaca gatctaacac aaggcaaagc tggcatttaa acatagaccc acctccaaag 27000 tccagtgtgc tggacacacc tgcagaagac aaatagttcc cccatatttc aatctctctc 27060 tctgttggaa actgagtccg ctttttgtta ttgcttcccc catcagagtt caaaggcagc 27120 taggaaatgg ggtggtctct gctttgctgc ttaccacctt gtcacctttc atttgtattt 27180 ccctagagta gggaggcagt gccctttctt ggcagggtgc agtgggtgga aggagggtag 27240 ggctgtgggg gaaggggtca gaggagagga ttgcctctct ctaggtagtc aagggggcat 27300 acgtatgggg taagaggctg gttggcattg ggcattgcat tcggggtcaa ccattccagt 27360 tcccagatac acatgctgat agaatccttg tgacaaccct gtgaggtaga agctcttctg 27420 ctcctccttt tacaagtgtt gaaactgagg ctgtgtgcct tgctcaggtt gctgagctag 27480 cacacagtgg agtctgactc cagcctaggt ctgcctgcct cctaagtccc aactcaccac 27540 caccatcctg catttgattc ggttcagcct ctctgtctgc tgaggggact gtaggaagtg 27600 acagaaagga tgcagttgca taggtgggtt aggggttttt taaatcctca ttttcctgat 27660 ggagaccctg agacccaagt gtcttgctga actcagtaca ctggggactg aaattaccac 27720 ctgtcccctg gctgcagcct gccttttttg cagatgggtc caaacagcag atgtggatgg 27780 tctgggaggg aaggttcctg tggctgtgtg atgaggaga cgggggtggc ttgctggcca 27840 gccgtgtgtt ttaaccagcg cgtatatatc tttatttaaa ggagtcctat gcttttgaca 27900 atccatcagg aagctccctg tgacggagtc caaggggttc cctggtattg ctctgtgatc 27960 tttagacaag ccacttagcc tctgaacctc tatgttctca tctgcctgat gaggataaga 28020 gaatcccaac tccctgaatc aatgctaggc taggtgaaat caaacagcca acacaggttg 28080 gatgtgcact ccaggaggct tcctagcaat gtccccgccg ctcattcctc ctcgttatgc 28140 cctcagagcc cacatcatcc cctttgaata tgctcgctga tggcaagtct ccttccattc 28200 cgggtggatt taatgtttaa tgcagccaag gtcatttgga ggcaagtcta gggaattagc 28260 tgggtgacag agctgagcaa agagattttt gattacaaag aaagtgagga tgtgactcta 28320 tttctcagat aatctgggct gaaaggcagc tcccaagagg aactccaaaa atgctttgac 28380 gaaagccagc atcactggga attgggaaga gatgcccagg gtgaccatga ggaaggggac 28440 agcgctcact agggtgtata aataccggtt ggtcacaatt ggtctcctga cttcacagtc 28500 acaccctgct gctcctgacc agatgctgcc gtttcaagga gcaaactcgg tgggaggtca 28560 tataggtgtc cagtggaact ggggtaattg tggccgtctc aggtcaggct cagtccctga 28620 tccatgcgga ataaataatg gcccagcaag atgcctatac ctttctcatc ttaccagcca 28680 aacctgcaaa ttacccaaca gaacccatgc tgctttggct gggagggccg aatgagccag 28740 agcttgcaag agtctagctg ggggcagaag ggaggaagga tacacacccc ctcctgctcc 28800 tggtacctca tctgctcttg agaattagcc tggcagtggg agcccttcaa ctgggtactt 28860 cgtgtactgc cgtcctttga cattttcctt ctgggaaaac ttctagagaa gccattctgg 28920 gaaaggtaga gatttagaag ttttgaataa gaaaatagca agctgagaac ataatctggg 28980 gagaaagagc acagggcaga gaactctgaa tagtggcaga tggacttcca tctgaagacc 29040 gttgcagatt tgaacaaaat gagggaaatg acaagagccg gaagccttcc aaaaggaacc 29100 gcttccattg aagtctgtcc ctgattctca ggttagagtc ttcctcattt gggatgtgaa 29160 aatggttttt cttttataat gtgatgcttg tactaggttg ccttttccca cgttttatgt 29220 tctcacttga caaatagcgt caactttgta ttggtcccag tttgggtggt ggtgaacggg 29280 agtgggaatt atcttgtgtg gttggaagat gggaaccact ggcctagaac ccagaaactg 29340 gaaactagct gtcctcaagc tgggccttaa gtctctgtag ggaacctggg gacagaaagt 29400 gaagacacac gaacaactgt ttatatccgc catcctccaa cgggcaggct cctatgggtg 29460 gggctccatt tagcccagga attctcctct tcccattggt gctctgctct tctgctctgt 29520 gcagagggca gctggttcta aggtccagag atataagatt tcttcgctgg tttaagcagc 29580 accgagagtg tggtcctctc gctctccctg attgtgctct gagctctggc ctcttgcagg 29640 gagttgccag acacatgtgt gagaagaagg gctccttttg ccgttttacc ccgggtgtga 29700 tcacagctcc ggcccaggcc actactgagc cctacactgt ccaatattca tatgggaggg 29760 ttgagacgag aaaaggcact aaacatcctg tgtcatagga aaagggaaca aaagaggaag 29820 cctcgaaaca gactgggagt tgtcattcat gaaagagtga gccttccaaa tccccccacgc 29880 tggctggtct ttacagcctg gaagacttca gattaaagag accatgatga atggggaccg 29940 tgaggataga ttacttcagg gaacacctca gtgtcaccca gctgatggtg gccccaattt 30000 ctgggcagtg ggtggggagt ggaggcctcc agccctcttc gattctgacc ttcagctgca 30060 gcattccttg agcattcgtg gaactttagt actgcaagat actctcaggg gaaacagctt 30120 cctggggagt tcgccaaaga aacagaacca atacgatgta tagtcatgtg ccacataatg 30180 acatttcagt taatgatggg ctgcatatat gatggggtct cataagatta taacactgca 30240 ttttttacac cttttctttg tatagatata cacataccat tgtattacaa ttacctacag 30300 tatttagtac agtaacatgc tgtacaggtt tatagcctag gagcaatagg ctttaccata 30360 cagcctaggg gtgtagtagg ctatgccatc taggcttgtg caagtacact ctatgatgtt 30420 cacacaatga tgacatctcc taacaatgca tttcattatt aagcaatgga tgactgtgtg 30480 tgtatatatc ctttatttat gtatataaag agatttatta taaggaatta gcttacatga 30540 ttatggaagc cgacaagtcc caaaatctgc agggtaagtc agcaagctgg agacccagga 30600 gagctgacag tgtaattcta gtccaaaggc aggcagactt gggacccagg aagagccaat 30660 atttcagtct gagtccaaag gcgggagaag gctgatgtcc caatttgaag gccattgggc 30720 aggaaggatt ttatttctct tgggagaggg tcagtctttt tgttttattc aggcctctag 30780 ctgattggat gattgcacag ggcaacctgc tttacttaat ttgctgattt caatgctaat 30840 ctcatccaaa aacaccctca tggaaatacc cagaataata tttggccaaa tatctggaga 30900 ctccatggcc cggtcaagtt gacactcaaa attaaccatc atagcagtca catgagtttg 30960 ggagattctt gtaaaccatg gccctgtctt cggccttcca gggcatttta gtgtagtaaa 31020 ggttctgaga atgcagtcaa gaaacctatt tgacttgttc actcaagtgt tttccttatt 31080 tatttggcca tggtactttg tggggactgg ggaggaggga aggagggaag ggccatgatg 31140 cctgttgaat cccatgactc tgggaactat ccattgggaa acaccaccct ggagatgtaa 31200 cattagaaag acactgctgt gccagctgca agaaagcggt ctgtccatga ctggggctgt 31260 ggtgcatttt gaggcttcca ggcactgtca tggtcaagct gcatcccaaa gtgaaaggac 31320 tcaagagaga actttctggg aattctttct ttcttttctt ttcttttttt gaaatgcggg 31380 tctcgctatg ttgcccaggc tggcctcgaa ctcctggcct caagctaccc tcctgcctca 31440 gcctcctaag tagctgggac tacaggcatg acatcccact cagctctggg aattctttct 31500 ttttctttct ttttttcttt ttcctggaga cagggtcttg ctctgtcacc taggctggag 31560 ggctggagtc cagtgatgtg gccacaggca tacaccatca cacctggcta acttttgtgt 31620 tttttgtaga gacagggtct ccccatattg gccaggcagc tttcaaactc ctgggctcaa 31680 gcaatcttcc tgccttggct tcccaaagtg ctggaattac aggtgtaagc caccacaccc 31740 agccagaatt tgtaattcag ctgcacttag agggtgttta cttggtactg gctgagtgct 31800 aagtgctttg tatgcatgat ctcatttaat cttttcaacc actttttgca ttaggaacta 31860 gtgtctcatt ttacagataa agaaatacgc acagagttgt gtgactttct cacaagtggg 31920 aaatcaggat ttgaacctag tcctgtctga ctctagaaca atgcccttaa ccactctacc 31980 ctgattccca ctgtgtggct gggaaatcta taggcaaaaa caaaacagag gcctcaccag 32040 gcatgtggtt tgaaatcaaa cagtttatct gaaagtcctt aactgatagg atgccttttg 32100 atggcaaaag ggaaaatgaa gagatgaggg aatgggagga agtataatac tgttagggaa 32160 gacagacttt gcatgagggt aagatgtggt catgtcgaag agggaaaggc agagcatagc 32220 tcagggtgtt ctgagccatc atctgccttg ttggtgacag agagaccctg ctcagctcta 32280 catttccttg ctgcacgagg ccccggtgcc ctcagaggtg gtccctgaga gtgccagaga 32340 ggtggaggtg gtgacaggtg gtaagaccct gctgagcagg accatctttt tttttttgag 32400 acagagtttc actcttgttg cccaggctgg agtgcaatgg cacaatctca gttcactgca 32460 acctccgcct cctgggttca aacgattctc ctgcctcagc ctcctgggat tacaggcacc 32520 ctccaccacg cccggctaat ttttgtagtt ttagtagaga tggggtttca ccacgttggc 32580 caggctggtc ccgaactcct gacttcaggt gatccaccca cctcggcctc ccaaagtgct 32640 gggattacag gcgtgagcca ccatgcccgg ctgggagcag gaccttcttg tgctccaatc 32700 attggtgtga cttggacaag tctacatact ctcaaatatc tggtgtgctt tctgtctatc 32760 tgctgtgcaa acaaggttgt tgcatcctat ttttgcatta gggtgttcca gaaaggaaga 32820 gtctcatgtg tatgtgtgtg tgtgtgcgcg cgtgcgtgtg tcttcagcaa ccagtactca 32880 ccagggacct agccatagga gtgcccacaa acagtgtgtc tgcatatgtg tgtgtagata 32940 cataccacac ataaatgtat tcctgtatca caaagtactt ttaaattctt tatatatatt 33000 atttatataa tattatataa tataattaat tatctgtctc tcccaccaga ataaaagttt 33060 cctgaggtca aggacttcct tttccctgcc aaaatggtgt ccagaacttt gaggtatcta 33120 ataaatattg tgaatgaatg aatggccaga ccatgggctg tgatctctta gctaatgtcc 33180 tagaatttac accttcagca gagccccttg ggaaatggca gtcagcgttg cagccacctt 33240 cacctcttcc tccaccgtct cctcttcctt tattgtttct gcctcctttt ctccctcccc 33300 ttcccagtgc ttagaatcgt ctctggcaac agctccagcc cagccttttg aaaatacact 33360 taatgatggt tttgactttt tttctaaaag caacaaaatc atttggaacc aagaagatta 33420 gctgtttttt tggccactga ggtccttaac tcagagatga taaatagggc acggtaatca 33480 gatcagtatt ttgttgtggg cagtaaacta tctctaatgg tcattcccct tatagaggag 33540 ggctcagtat gaaagaacag ggacagagag acccaggaag cccctcagaa ggggacagac 33600 ccagctggat gttgacattc tggttgcatc gttttctaaa gcaatttcct gagtttttgc 33660 cctcctgtgt gtatttacat agacacgaac tttaagcctg acacctcaga agctgtttgg 33720 gaaggatggg ctcgcagatt ttgtttttgt ctttgtttgt ttgattgttt tttagatagg 33780 gcctctctct gtcactgagg ctggagtgca gtggcgtgat cagagctcac tgcagacttg 33840 aaactcctcg gctgaggcaa tcctcccacc tcagcctccc aagtagctgg gactacaggc 33900 acacaccact gcaccactac cactacaccc ggctaatttt ttttttgtag agacaggttc 33960 ttgctgtgtt ggccaggctg gtctcaaact cctgccctct agcaatacgc ctgcttcggc 34020 ctcccaaact gctggggtta caggtgtgag ccactgtgcc catctggttc ccagaactga 34080 agaaggcctg gaacctagag ggcagatgaa ccgataatgg gagtgtttcc ttgtaagttg 34140 ccttgggaag tagtgtgggt ggtttatctt gggcatttaa gtccatgagc atgatcagaa 34200 gaggtagaat gcttccaggg ggcttgttgg tgagacctca ggaaaatgga caaaggaaaa 34260 gacagaagga aaatggacaa agctcgggat ttgcacatgg cctgctgtag ccaaactacc 34320 cttaggattt agcccttctc cctgccaagc ctctctgagg tcgcgccact gcactccagc 34380 ctggcaacag agcgagactc tgtctcaaaa aaaaaaaggt gtggtggcat gcacctgtag 34440 tcttagctac taggaaggct gaggcaagag tcacttgagc caaggaatat gaggctcagg 34500 agtttcaggt tacagtgagc tatgattgtg ccgcgtcact ccagcctggg tgacagagtg 34560 agaccctgtc tcagaaaaag ggaaagaaaa tctaacctat aaattatttt ctaacataat 34620 gaaatgttta cgaatatacc attaatgaag caagttgaca ttaggttgtg ctttgtggac 34680 atttaattac acatttaaac attttgatct tgcatttttc cttttcatat ttggggatta 34740 aaaatgtatt tgcatatttc aagcatgttg aaggtctttg gaaaaactca aaggccagaa 34800 gctctgtgcc tacagggctg agtggacaaa ccgcccctgc tccggcccta agaaattaca 34860 gagtaaggaa gaggcaaggg aggacactgg agaaaaatga agcattgact ggagatgtct 34920 ctgagggtct ctgagggtgg gaggtggggt tggggctggg agttagggct tggttctcaa 34980 tggttttctg atatctagtt catttaatcc ccattgcctg gggagctctt cccctaactc 35040 tccagatacc cattagctcc cttcctctct tcattaaaga ttctactcaa atgtcacatt 35100 ggttaaaaca gtgccccggc tgggtgcagt ggctcacacc tgtaatccca gcactttggg 35160 agactgaggc aggtggatca cgaggtcagg agttagagac cagcctagac aacatagtga 35220 aaccccgtct ctactaaaaa tacaaaaaac tagccaggta tgatggcagg cacctgtaat 35280 cccagctact tgggaggctg aagcaggaga attgcttgaa cccagaggca gaggttgcgg 35340 tgagccaaga tcatgccatt gcactccagc ctgggcaaca agagcaagac ttcgtcaaaa 35400 aacaaacaaa caaacaaaca aaaaaccagt gccccatcct tgcccatcct tgtctaacac 35460 aagatgtagt gctaagaagc cattaatgcc atgtggacaa ataaacagac taattgggta 35520 gggagagtcc tctgttattg attagtctgt ttacttgtgc gtgctctgtc ttgatccgcc 35580 tcctgcgggc agggaatgtg ttgtattcac cagtgtctgg cacctaaagg ctccacaata 35640 aatgcgtggt tgttggcaca atgaatgaac aaatgaataa atgaatcttg gccctccctg 35700 cctccagtgg ctgttgggag aatcaggtga gagaaaatgc agtcttcaaa ggataagctg 35760 atgtgccgtc ggccccagga gtcacagcac attttctctt tctaggagtc cttaaaatgc 35820 aggcagaagc tcatcctcag aaattctgag tcagtcggtt gggggcagag accagcgatc 35880 tgaatttaac aaactctttg ggtgatactg atgctgctgg tcatcagcct atgctgggag 35940 gagactttgc tgacaactag ctgtcacttt ttagtcattt tgctgagcgg gacacaaatg 36000 tagagccaca atgcaatgtg accctagagc ccatggttcc agagtcgggg gttgcccctc 36060 tccatgtttg agggccgaag agcctgcatc gagcagagcc accaggctaa atcctctgac 36120 cttgactttg gtttagggac cagagtctgg tatctaagtg cgatcttact ctagctttcc 36180 catctgttct gtttaggcca gaggtgatcc agtgatttgg gagctgcagg tcacacaggc 36240 tgctcagagg gtaagttggg tccagtcggg ccagcagggc cacatggccg attcacactc 36300 agtccaaaac cctcgtggct gagcattgat gcagaccatg ctgtcttgtg ggagtggtct 36360 gggtgcctct aggagggcag aaataccaca ttactgcctg gtgaccttgg aaagggggac 36420 agaggtgctg gcactgggat gctgagcagc caaagccagt gagacccacg tggagggagg 36480 cagctagctt gcttgcttcc tgaaagccag acagagcctc tcagcctaat ttgcttgtgc 36540 caggcagcct gtgaattctt atagccaaac cacctggtgg gtgactgttg acaggggact 36600 gccgggtcct ggcagcccag ccctagcaca gacaccaggc agcacacaga cctcaggtca 36660 cataggcact ggccagtctt tgaggacaca gtgtctggct ccagttattt ctacctgcag 36720 tacagtctcg gggccctgag tcaacaggcg ggtttgagag gacttcaggt cttggcccca 36780 aaaaagtgca catgaccagg ttcacggtca cctcaggcta tctggcccca ctcattgatt 36840 catgcttatg ttcattctac agaaattatt cagcaccttc tacgaagaca caaagaagga 36900 aaggagttcc catctgtcct taaagaactt aactgttaaa tgatgtccca ggctgggctc 36960 agtggctcac gcctgtaatc ccaacatctt gggaggccga ggcaaaaggg tcacttgagc 37020 ccaggagttt gagaccagcc taagcaacat ggcaagactc tgtctctaca aaaaattttt 37080 aaaaattaac caggtgcagg tgcatggggg tgcatgcctg tggtcccagc tcctccggag 37140 gctaaggtgg tggggcgatt gcttgagcct gggaggtcaa ggctgcagtg aaccaagatc 37200 acaccactgc actccagcct gggtgacaga gtgagaccct gtctcaaaaa aaaaaaaaaa 37260 aaaaaaaaaa aagataagca ctacatagag cagtgggcag cccccaaatg catagagctg 37320 gcatgcagca ggcactcagt aaatcttggt tgaatgagca aggtgctgga ggagctagga 37380 ggagagagtg agaaactggc cagggaaagc tcctgcatga aggaaaagga aaaggcattc 37440 tacatgaaag gtgtgaatgt tacaaaatat atgaggagta atgtggccat gtggagaagt 37500 aagagctcac ttccattgag cgcttcattt caaccaggca ttgttctgaa catattacac 37560 atatcatctc tttaaccttt gagatagggc ctattgttgt cactcccatt ttataattgc 37620 acagcctgag gcccagagag gctgagctta aggccatgca ggtagtgagt ggcagagtca 37680 ggtgttaatc cactcaccaa tgggcactta acccaacctg agcctccact tctccatctg 37740 taaaatggga acgcccaggc ttcccctgac agtttcttgg acagattaag aaagctgtgc 37800 atgagtgcac atggaatgtc tgtgaaaaag ttacaagatt cacagaaaac ttgctaacaa 37860 tggttacctt tggggaggct gcctagagga ccaaggatta gagaaagtat gtatcagttt 37920 ttggatctct ttttgggcct ccagcgggtg aaagttaaaa tgacaagcag cctaaatggg 37980 aaggagttgg agggtgggtt aagtttgaaa ggagaaagag cagttgaggc tggagaaagg 38040 atgttatttg actgtagcga acactctgcc tgcacccccc agtccctctc tctttgaggg 38100 gaaggatgcc gtggcgacgg tcttcctcct taatatagta tgtacatttt atctctgcag 38160 acttcttgca gacttggttt aaagatctca gctcaatacc attagtgtat atctgcagag 38220 ggccctttgt aaaattgatt agaaagtggg cttttgcatg tggggtgggg gcgggggtgg 38280 gacctaatcg gatttgagca tgagatggta tctaattccc tgcatctagc aactggcttg 38340 gggacctccc tgggagccag ggccccccta atttggtttg caaatacatt agccaaacaa 38400 gctgaggggg ctcctttggg gagagggttt ttgggggatg gggatgggag atggtgggaa 38460 ggctgaggaa atgaagaagg gaagggtttt ctgtgcaggt cctggagtat aaaccgtaca 38520 tgcgattgcc aaggctgtgc atgtctcatg gttttacccc attcgggaga atgaagcaaa 38580 cttctaagag gaccaggctg ggcctggtgg ctcagtcctg taatgccagc actttgagag 38640 gctgaggggg gtggatcacc tgaggtcagg agtttgagac caccctggcc aacatggtga 38700 aactccgtct ctactaaaaa tacaaaaact agccaggcat ggtggcacac gcctgtattc 38760 ccagctactc aggaggctga ggcaggagaa tcacttgaat ccaagaggtg gaggttgcag 38820 tgagctgagt tcatgccact gcactccagc ctgggcgaca gagcaagaca ggtctcaaaa 38880 caaacaaaca aacaaacaaa gacttggtgt attgcttacc atttttgagc cattatatat 38940 acattttgtt tcattttttc agtcttttaa aaaaaagtaa tacattcaca tgtgtaacaa 39000 aaatgtcaaa cactatgaga gtgcaggcag tgactggtag ggtatttttc ctcccctaat 39060 ccttggtccc ctagacagaa tccctaaaag tagccacagt taccaagttt tctgtgaacc 39120 ttacaatatt ttcaaaaatt gtccatgtgc actcatacac agctttctta atccctccaa 39180 gaaacctgca gaggaaactt ggtgttccca ttttacagat ggagaatgga ggcacaggtt 39240 ggttaagtgc ccactggtga agggccagga tccaaattgt gaatgatctg gtggtctggc 39300 tttatatcct ggggtctttc tgtgaaatca tatgctctct tatgtgcctt tcccagaaag 39360 agagggggct gttcagagct ataaacacag caaatatttg agtttttact tctccaactc 39420 ttttcttctt attttttttt atttttttat tttttgagac agagtctctc tctgtcaccc 39480 agactggagg gcagtggtgc aatctcagct cactgcaacc tcccccttct gggttcaagt 39540 gattcttgtg cctcagcctc ccgagtagct gagattacag gcaagtgcca ccaagcccgg 39600 ctaatttttg tatttttcgc agagacgggg ttttgccttg ttgaccagtc tggtcttgaa 39660 ctcctgatct caggtgatct gcctgcttca gcctcccaaa gtgctgggat tacaggcaag 39720 agccaccgcg cctggcccat tcatttcttc ttgggtccat ccatatgcta tcgttttgtc 39780 cacttatacc caagcatcct aaaaacagga tgcaaggctg ggcatggtgg ctcacgcctg 39840 taatcaatcc cagcactatg gaaggccaag gcaggcagat cacctgaggt caggagttca 39900 agaccagcct gatcaacatg gtgaaacccc atctctacta aaaatacaaa aattagccgg 39960 gcatggtggc gggcacctgt aatcccagct actcgggagg ccgaggcagg agaatcactt 40020 gaatctggga gaaagaggat gcagtgagct gagattgcgc caccgaactc cagcctggac 40080 aacaaagcaa gactccatct tccaaaaaaa aaacaggagg tgaacttgca agggcatctt 40140 tactacggtc tccttcagtt cagtacccct ttatgagagt gaggggtgga gtgtgttgag 40200 tgaatcctcg cctgctttat ctggatcttg agttctgccc acttcctact agacactgtg 40260 tgtgttgcag gaaggaggat gctggtggca gcacgtgctg caaattgtgt ggcagcatcc 40320 agcttcataa cagataatca cagtatcaac ctcggagggt tctttggagg gtggaataat 40380 accatggcat ggtacctggt acatggtaat ctctcaataa atattagtga ttagtagtat 40440 cactagctag agaagctttc gtacattgct catctgctct gtgcaatttg cctcaactat 40500 aagaatagta ttattctgtt atcatcacac tattatttaa tatttaatat ttttaaacaa 40560 tctgtgtaat aagctggtat cattttaaat acaattagca tagtgtcagg tatacaaaag 40620 atgctcaata aatatgattt cccattttat tcccgtctct ttaccagttt taaatcaaga 40680 tcttgattct tctttatcct tgttgtgaat ctaatttctg taaagtgagt ccatttgtat 40740 tcccactcac atttattgag aacctgctgt ttacctggca ttctgctctg tgctgcgggg 40800 cacacaaaga agaacagacc tcggactccg ccctcacagg acgaaaaatc aaatcaggaa 40860 gactgagaac agaggcatca attgcagccc aagctgttcg cagggtttgg ggcatgctcc 40920 tggggtacag gaatagatgg agtggcttca tgttcttcag tacctcagtt tccccttctg 40980 aggagtggag gtagttccct ttcttgtttc ttggtatttg gaagatgtgg aacaacctgg 41040 ctgatgtggt ttcagtcttg tgggaaccag tgggctgagc ccctttcttt acccctctac 41100 ctctccctca ccaccaagta ccctatacct ctctcccacc ctaccctggc tggaagctgc 41160 tcctccactg ggctgtcgac ctgggagcct ccatcctcct cctccttgca aaccacacct 41220 tttcaccaga tcgtcatgcc aaccccatcc tcccccaaca aagaaggttt tgaagggacc 41280 agaatacctc agctttggat gctgtactat aaaatccaga attatataac tgctggatta 41340 tggagtgatt attagctttg ctgaaagatt ttccatttac ataaggatta gctgcggggt 41400 tcctttaaat agctggcttt gctaatgcat ttgtattgca aagaaaggtg ggtgggggaa 41460 ataaggacag gattgtgaag cagaaggccc gagttgcagt ggctcaggcc tctaatccaa 41520 atgactcagg aggccggggc aggaggatca cttgaaccca ggagttcaac accagtctgg 41580 gcaacatagg gagaccctat ctctacaata aattaaatta aattaactag ggatggtggc 41640 ttgtgccttt agaaaaataa agaaaagaag gctcgagttc taagccagct gagtaactgg 41700 tcattttacc tcttgaagcc ttgggtttct ttgatgagga aagtgagcgg tgaccaccct 41760 acccagaccc agcattgcag gagaggactg tgcaggcagt ttgcaaagag ctgggcgcag 41820 gcagtcaggt gaggcaaagc tgcaccgcag tgctgttggt gtgatgagcc tgcccctcaa 41880 agggtgatgt cgaaacccct ggtgttgaat cttctagctg gcctctgccc acctgtccat 41940 gctggtctcc tgacagaccc ccacctggct tcttcctgtg ccccggcccc ggccacacac 42000 ctgtgtcccg gacttcccac accaactcca gttccttggc tgtatactgc tgttccctat 42060 ctctgtgact tgcacatact ggtcccagtg cccagaatgc cattccccac cctcttccct 42120 tcttggcctg gcaaacacct acttgtcctt caagacgtag gctaaacttc tcctccagga 42180 agccttccct gactacctta cactaaggag ggttagacac tcctctgcac tcgcaggtcc 42240 catgaatgtg tgtgtgaccc tatcgtattg ctttgagatc cttcattgtc cagtgacttt 42300 atggtcattg atcacttatt tgtatctgcc atgagctact gagcttaggg gcagggtccc 42360 tgttgtgttt gactcagtag atgtgtagta aatgaaataa gtaagcgaat agtaacaact 42420 tctcatgtgc agcaggtgtt tcatccccag ccacatgcag cagaggcggc ccccgcaccg 42480 tccccccaccc cgtaccatcc tcacccctgc accatcccca cccctgcacc gtccccccgcc 42540 cctgcaccgt cccctgcccc tgcaccgtct cccgcccctg caccgtccgc cgcccctgca 42600 ccatccctcg cccctgcacc gtccccgccc ctgcaccgtc cgccgcccct gcaccgtccg 42660 ccgcccctgc accgtccccg cccctgcacc gtcccctgcc cctgcacggt ccccgcccct 42720 gcaccgtccg ccgcccctgc accatccctc gcccctgcac cgtccccgcc cctgcaccgt 42780 ctcccgcccc tgcaccgtct cccgcccctg caccgtcccc cccgcccctg caacgtcccc 42840 ccgcccctgc agcgtccccc cgcccctgca tactgcatgc cctgaagcac aaaaaccctg 42900 gtgttagacc acaggggttc aaataaatcc tggctccacc ccagctgtga ccttaaccaa 42960 attattttgc tcccgagttt cttcatctat aaaacaagat cataatagtt ctgacccctt 43020 agggttgctg tgaataggaa gtgagttaat ctgtgttcgg tacttagagc agtgcctggg 43080 cgcagtacct tctgcgtctg atggcggttt tcatttcgga gggccctgag ttgtgcccct 43140 gtggttcctc cccagctcag tcccctgtgt tgctgagctt gcagtctctg cctctttact 43200 ttcttcgctt gctctagtga cctgtctcag atccccactc ccccaaccag tcagcacaga 43260 aataatcaaa ttttacttga ttattagtca ttactttctg ctgctgtttt tgtttgttcc 43320 ttaaaaaaaa aaaaaaaaaa aaaaaaacta ttctagattt aattgagttg attgattagc 43380 acaatcgctg attggaagga gatactctgt aaccctctcc tcctccggtg ccttttccca 43440 gagaggcacc aggtggactg cccgtggcct ggaggtgcag tggcttgtgg tggctgtgtg 43500 ggctgggagc ctggtcctcc caggcctagt gacctgaggc aagtccccgg ccctctcagg 43560 gcctcatctg taagaagggg attgaagtaa atgagcctct gaatcccctc acttttaaat 43620 tctatgaaaa ctctacacct gagtgccccc agccttggtt tgtgagtcgc ccatccattc 43680 aatatcacag ctacctctgg gccagcactt ctcagggtgc tgtggggacc cagacgtgag 43740 caagtcaaga gccctgccct ctaggagcta gtggggtggg gttggggact ggcaagacgc 43800 taactccagc atttttaact tagtgtgttc caagctcagt ggagtttcag aggggaatgc 43860 ctaattcgaa cagttgtaga ggggtgacat ttggattcag tccaagacaa aataccttgt 43920 acaaacttta ggggtgtgga gagtgaactt tatagaagcc acctctatgt gctgagtaca 43980 gtggtaagca cttaaattgt tttaaaactt tttatatcaa atagagatag gatggccggg 44040 cacagtggct cactcctgca atcccagcac tttgggaggc cgagacgggc agatcacgag 44100 gtcaggagtt tgagaccagc ctggccaacg tggtaaaacc ctgtctctac taaaaataca 44160 aaaattagcc aggcgtggtg gtttgcacct gtaatcccag ctactcagga ggctgagaca 44220 gaagaatcac ttgaacccgg aaggtggagt ttacagtgag ctgagatcat gctactgcac 44280 tccagactgg gcgaaagagt gagactctat ctcaaaaatc aataaaaaat tagtaaataa 44340 atagagatgg gggtctcact gtattgccca ggctggtctc aaactcttgg gctcaaatgg 44400 tgctcctgtt tcagcctccc aaagtgccgg gattacaggc atgagccact gcgcctgata 44460 agcactttct tttcattttc tttttaatcc ccacagcaac actctaagta aaaggatatg 44520 atatcacttt tatagacaaa acacccaaag ctcagagagg ataagtggct tgcctacagt 44580 caacagcaag cgagggagaa gtagactttg aatgatgtca aaccttatcc tctttacaca 44640 gtttcatacc atattacagt attaaataat ttgaaggtaa aataatcagc taatttccca 44700 aatgtcactt ctatgtccat tttggaacat gatcttccat acataccctt tttacattac 44760 ataattagag tgatgtacca ttttcccttt tttttttttt ttttttgaga catggtcttg 44820 gctctgtcac acaggctaga gtgcagtggt gtgatcatag ctcactgcaa cctcttggct 44880 cctgggatca agggatcctc ctgcctcagc cctccaagta gctgggctat aggcgcccac 44940 caccacaccc agctaatttt gtatttttgt agagatgggt ttttgccatg ttggccaagc 45000 tggtctcaaa ctccagttca gactgccttt gtctcccaaa gtgctgggat tacaggcatg 45060 aacctgcgcc ccgcctctat ttttttactt atagcatttt ttccccccgt ctctgctttt 45120 ttgttctttt ctcttttttt gagatggagt gtcactcttg tcgcccgggc tagagtgcaa 45180 tggcgtgatc gtggttcact gcaacctcca ccttctgggt tcaagcaatt ctcctgcccc 45240 agcctcctga gtagctagga ttacagatac ccaccaccac acctggctaa ttttgtattt 45300 ttagtagaga tggtgtttca ccatgttggc caggctggtc tcgaactcct gacctcaggt 45360 gatccacccg cctcggcctc ccaaagtgct gggatttcag gtgtgagcca ctattcctgg 45420 cccatctctg ggttttgttc attgactcat atatttaccg agcacctact atgtgtcttg 45480 attctgagat aaaacaatta gtccaagacc ctgccttcag ggaacttaac cttaggtgga 45540 cagatgataa acggagaagc aataaaacaa ataatagaat gtcagatatt aagaatggct 45600 gtgaagaaag taaagcagga taagatgtag agtatatgaa attagccggg catggtggcg 45660 ggcacctgta atcccagctg ctcaggaggc tgagacagga gaatcgcttg aacccagaag 45720 gcggaggctg cagtgagctg agatcatgcc acaacaatcc aagctggcca atagagtgag 45780 actccatctc aaaaacaaaa aaagaaagaa agaaaaagat gtagagtatc gataggggtc 45840 agggtgtctt ccctgaaacg tgacatctca gcagagacct gactaatgat gaggtgagct 45900 gtgtgggtat ctgggtactc caggtagggg gagcagtcag tgcaaaggcc ctgggatggt 45960 gatgaccttg gcacacttgg ggaagagcag gagaccagtg tgggtggaat gtgggaaggt 46020 gggatgtgaa gttggaaagg tggctggggt caggtcacag gctttgcagg ccatggaaga 46080 gactggcttt tgttcctagt gtgtttctct ggtgtcttct agttcccatt attccacaat 46140 tcaacccagt ggatgtggtg ttattaatca acatcaatgt tgtttcctgc agcgtctgtg 46200 tgtgcctgtg tgcgtgcata tgtgtgtgtt tgcagcgaac acgcatttca agcatatttc 46260 aagcatgtga cttttgacta tgttggggta attctgtagc agcgaaataa ctggttggaa 46320 gtgtttgctc atctttttgg ctcttgacag gtaaaactat agtgtgactt ctggtgacaa 46380 gagctgaagg catggcaggc agtggatctg tggtgcaaag gtgcagaggc agaaagaaca 46440 agccttccca gaggcccgag gcatcacaca ggtagtccct ggccataagg gaggagccac 46500 tggagaagca ggtgcctcgt gaggacaggt gggcggtggg ccaagtgagc gcctcctctc 46560 tcctccaaga ggcagagcca ggtggggctt ttacatactt tttttttttt tttttttttt 46620 ttggtggggg atggagtctg gctctgtcac ccaggctgga gtgcagagac acaatcttgg 46680 cccactgcaa cctctgcctc ccaggttcaa gtgattctcc tgcctcagct tcctgattag 46740 ctgggattac aagacgcccgc caccatgcgt ggctaatttt tgtattttta gtaagacagg 46800 gtttcaccat gtttgtcagg ctggtcttga acccctgacc tcaggtgatc cacccacctc 46860 aacctcccaa agtgctgaga ttacaggcgt gagccactgc gcctgacctt tttccacttt 46920 tgaaaaagct ttttaatgaa attgtttttt ggctttacag aaaaattgcc aagatagtgc 46980 agaggactcc tgtataaccc ttatctggtt ttcacttttg ttagcttcct atgttaccat 47040 gatagatttg tcacaactaa gaaacttacc ttggtacatt actatgaact aacctccata 47100 ctttattgag atttcattta tttttccatt gatgtccttt ttctcttcca ggatcccatg 47160 cagaatccca cactgcattt aattgtcatg tctgtttagt ctccccttgt ctgtgacagt 47220 ttctcagact ttccataatt ttcataacct tgacagtttt tgtttgattg tttgtttgct 47280 tgttttgaga tggagtcttg ctctgttgcc caggctggag tgcagtggag cgatctcggc 47340 tcactataac ctcccacctc ctgggttcaa gtgattctcg tgcctcagcc tccctagtag 47400 ctaggattac gggtgcctgc caccatgcct ggctaatttt tctattttta gtagaaacag 47460 tgttttgcca tgttggccag gctggtctca aactcctggc ctcaagtgat ccgcccacct 47520 tggcctccaa actaactgct ggaattacag gtgtgagcca ccgcatccag cctaaccttg 47580 agagttttta gaagtgctgg ccaggtactt tgcttttcca tttttcaact atctattttt 47640 atctggaatc atgatgttga gagcctgtaa actttttttt ttttttgaga cgaggtttca 47700 ctctgtcacc ctgcctggag tgcgatggca cgatctcggc tcactacaac cttcgcctct 47760 caggttcaaa cgattctcct gtgtcagcct cctgagtagc tgggactatg ggcatgtgcc 47820 actgtgcctg gctaattttt acatttttag tagagatggg gtttcgccat gttggccagg 47880 ctgatctcga actcctgacc tcaggtgatc ttcctgcctc ggtctcccaa actgctggga 47940 ttacaggagt gagccaccgc acacggctga gagtctgcaa aatgttgaga tcgagcttcg 48000 aactcaggaa tcaagggtgg gggacacggt gctgggttca gtcctggcct tgccccctac 48060 ccactaagtg acattgaaca aggaaatctt ccatgcttca ttcttatcct gggggtgaga 48120 atattcaccc ccgagcctca tgagggttag ctgggataag acatggaaat tctcatgaac 48180 ttggggttcc ttctcagttt cattgctggg taagcccctg gtgagactga ttaccctgaa 48240 gacattcact tcctctcaca ggagctgggg ctgtgaaatg ccagagtgag gatggcgggg 48300 aggttgtgac aacttggcag gaagcacttt gaaggtcgta ttctatattg atcctcacaa 48360 taactccatg agttatggta gtaaaatggg ttactgtagg ctcatagaag gtcaagaacc 48420 tgctgaaggt catggaggaa agaagggcaa agtcaagact tgcacatggg ccatgagacc 48480 ctgtgcccct tccagtttag gctggcctga gctgcccggc agagggggca ggcagctctg 48540 gggtggatgt gggcaggaaa gcccagagcc ctggatcctg ggatggagag ggtctgtctc 48600 atgggtcagg aggactgggg ttcggctagg ggtctgactc acggggcaag aggctagagt 48660 tatggattct cagtctttac acaccatatt ggtctcaggc cattgcatta cagtgagtgt 48720 ttcattttgt aatgtagact ttttttctct aggtaatttc atttttaacc cttgagttac 48780 ctgtgaaacc agcatgagca aatgagcaaa aggctcatga ctagcgggca gcttcccagg 48840 taaatctcag gaccaatggt ccagcttcct gccagagagc caactgtctt acctcctgtt 48900 tcatgtatct tcaggccccc ccagcagatg gtgagggctc tctgctttcc aggaagggac 48960 aaagaatgac tgaagccaga cagggcaagt ggctgtctct aggacacaca gcttcagagc 49020 agacaccata tcagttagtc actgggctct ttctaccaaa cataataaga actcagaaga 49080 cactcgtgct atttattata ttttaaaact tgaaatgtaa actacaaagt tgcagttccg 49140 acattaatgg gagagttggg aggccacagt tctaagtgca tgagctaata ggtcttctcc 49200 tacagggtgt gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttt gtgtatgaga 49260 gagagagaga gagacagaga gcaacacatt taggtcagtg cactgtgagg aacaaagtaa 49320 ttttggcact ttggccaaat ggccaaaaat taccttcaat tcaaccaaaa cacacagagg 49380 ttggagggat ggacggtcct tttcaaaaag gggtcccctg gaaccggtgg ccaccatgcc 49440 ctttgtatca ggggttccca tttcatccac ctcaaagttt ctaaattcag agcttgcaga 49500 ccaccctcac acaccccacc tgtgcacatg gatgacatgg ccctgctgat tcctctggct 49560 ctaaatgata cctcttctgc ctgtcccctg cagtgaggtg tgcccaggta ttcagacccc 49620 tgcagtgtct cactgagcac cctaagcact cacccgtcac cctctggttc cttggggccc 49680 ggtgctggcc ttggaacact ggtcccagta ctcaggcagt ccaggaaata gtctgtttgg 49740 cctgccagct gtcagcagcc ttgcccctcc tcccagcctg gatccagccg gaggaggaca 49800 gagcccgttt ctcttctgcc cacctttaaa ggctaggctg gccaggatag ggaagaagta 49860 gccctgtctg gagtcacccc tccagagatg tgtaacccca gagtggttaa aatcccatac 49920 attggcatca ggatggctta gagggcaaat ctttgccttt ccatgtgcat ggaaggtgtg 49980 gggcccacct gacaatgtct ggtgcctcga ttgattttcc catgtataaa ttaggatgaa 50040 aaatccagag ttattttgag gagtaaataa gcttatatat gtaaagcgct ttgcacatag 50100 caagtgctta aaaagaaagg aaatgtagta ttgttattcg gttatataat atagcagcat 50160 ttgtgtctct ttttcttcca aagagcttgc acatctgttt actccatgta cccttacaac 50220 aaccaagtgg agtagggcag tttttcttgg atccagttta ctgatgcagc agctaagatg 50280 cagtgaagtg taatgacatg cccaaggcca ctccacaaag cagcaggggc actgaggtcc 50340 ctggagggca caggctaggt taggtgtgtc ccagtctggc tcacctgcag ccggaattcc 50400 tgcctgccac agctgcccct ccagtccccc tgtcactctc ctccctcccc tccctgagaa 50460 ctgctgtctt ccacaaggac ccctcactac ccagggaggg agggtgtggt tgggcgctgg 50520 tagggggtgg ctctacctct tcagccagtg gcagggctct gccattgcca gcagcatctt 50580 gcaggatgaa ggttgcatca gtgagcagta attgaaatgc aaaataacat tttgatcgag 50640 ccagcaggct gtttatttat cagatcaata gtcaaaatgc cccgtctgga gaagctagtg 50700 tgataagtga cagtcttgcc aagggcagtc ctggtggcta cagtcccctc cctcaaaggc 50760 ctggattaga aagccaagga gcctgggagt gacccctacc tctgcttctc ccttacagaa 50820 tgtgggcacg cacacgcaca gcccttgcca catttccttc tttttttttt ttttttttt 50880 tttgagatgg agtctcactc tgttgccagg ctggagtaca gtggcgcaat ctcagctcac 50940 tgcaacctcc gcctcccggg ttcaagcgat tctcctgcct cagcctccca agtagctggg 51000 actacaggca cgtgccacca cacccagcta attttttttg tattttagta gagacaaggt 51060 ttcaccatgt tggccaggat ggtctcgatc tcctgacctc atgatctgcc tgcctcggcc 51120 tcccaaagtg ctgggattac aggcatgagc caccacaccc ggccgacatt tccttcttat 51180 actcagttta cagaggagat gactgagaac tatgtgggta gggaccaccc ttgctgtggc 51240 tgccaggacc tgtacccaag attgctgaga taacagcaca tattttcgag cacttacaat 51300 gtacaggtgc ccaatgcttc acattattgg gtcatttact cctcagaata attctgtgag 51360 gtacgtatgt ctatattacc cattttgcag atgaggaaac caagtcctag agaggtcagg 51420 caacagttgc acagcgagtc agtgacaggc cgggattccg acacaggcga gctgggccca 51480 gagccctcat gcccaggccc tgtcagttcc ctctctcaag ggcagggggc cgtgaaacat 51540 ttttgtttac acagtggggt tctggctctg aagtcaagca acccctttcc agccccactt 51600 cccacagttt ctttacgaat tacattgatt ttgtgttaaa atttagtttt tagcattttg 51660 aaagcagatg tctcaatgag ttgctctcag actagcctct ctaagttgcc aacccaacac 51720 attaagtagc ttggggtact tacaaaaaag caaccaaaat cagaaaataa gaaaaatgca 51780 tatatctttc ataacctttt tttttttttt tttttttgag agagtctcac tctgtcaccc 51840 aggctggagt atagtggctc aatctcggct cactgcatcc tctgcctccc gcgctcaaga 51900 aattctcaca cctcagcctc ctgagtagct gggattacag atgtgtgcca ccacacctgg 51960 ctaatttttg tatttttagt agagacaggg tttcaccatg ttggccaggc tggtctcgaa 52020 cttctgacct caagtgatct gctcactttg gcttcccaaa ttgctgagat tacaggcgtg 52080 agccaccgcg ccatcctttc atagactctt taaaccagga tgatcagaat tcgatcgaaa 52140 ctgatggcaa ggtggatcct ttaagaactt ttgtgggctc cactggaccc caggggctct 52200 gtgggttctg ctcctggggc gctggtggac tcctcttctc ggaccttgat cctgtcctgt 52260 gactcagacc ggtgactgtc acatcctgag ggagtgcagg cctctggaaa ctgtaatggt 52320 tgtttgactg gggtcctcag atcccaccta accctcctta ctcattcaac aaatatttat 52380 tctgcaccta ctgtgtgtct attctagaca ctggagtagg acaggaaaga aaacagaaag 52440 cctctgccat catatacggg gagcaaagac cctgaggtgg gagcgtgatt ggtgtagtca 52500 agaaccagcc aggaggccag tgtggctggg atggagtgac ctggggggag agtgggcagg 52560 agatagcatg acagaggttg gggggcagat cctgaggcct tctgagctgt ggaaaggact 52620 cctgcttcac tggagcccct ggctgtcttc agcagaggaa tgttgtgact tacacccctt 52680 catgatgtaa ctcatgacag cactttctgg ctgtgtggtc cctgccgaga tatttagcgc 52740 ctctgggcct cagtttgctc ctctgcaaaa tgagggaaat gatagtactt caactagttg 52800 ttgcaaggaa tcagtgattt actaaccatt gtcccgagca tagagcaagc cctccatatg 52860 tgagcactgt tgttgttaca gagatcagaa cagggttctc agctggctac agtggccagt 52920 ctccatctgt ccacctgagt taagatgcct ctttgtcatc tgcccaggct gcccatttgc 52980 acaaagactg aaaaattgag tcaggatgag ccctaagctt cctatgtggg ttctgctcct 53040 ggggcgctgg ctgatcccct ttcttggacc ctgatcctgt cctggtgtgc acaaggctat 53100 gtagaaaggg ccatggccat gaccagggag tggatagaag tgtcgtcccc ttcgttgtgt 53160 gggcctgcac actgtccttt gggaatgcac aggggggcagc agtgaggctc agtcacatgt 53220 gtgatcagag tggaggtcag caacataagc caagcacctt aaacgctgat tccatcctgg 53280 gttgtataag cagaagtata gtgtctagga tgagggaggt gtcagtactg ctctgctctg 53340 cactgggcag agctcacctg gagagctgtg ctcagttcta atgctctttt ttgtttgttt 53400 gtttgtttga gatagagtgt cactctgttg cccagactgg agtgcagtgg cacaatcttg 53460 gctcactgca acctccacct cccaggttca agtgattctc ctgcctctgc ctctgaagta 53520 gctgggatta caggcatgca ccaccacgcc cggctaattt ttatattttt agtagagatg 53580 gggtttcacc atcttggcca ggctggtctc aaactcctga cctcaagcga tctgcccgcc 53640 tcagcctccc tgaggctcac acctgtaaat cccattatag gtgtgagcca ctgcgcctgg 53700 cctgatgctc ttctttaaga agagaagaca gagcagatgg gttattctca gaagtgcagg 53760 ggatgttgac cctggtgagg agaggggagg atccacaggg agcaggagct gccttccgca 53820 gtctggaggg ctatctcatg gaagggctta gacttgttct gtaggtcatg aggggtgggg 53880 ttgtataaac tgtaactgga agctcagagg gaagaaatac ttttactttt cacaaaaaaa 53940 ccttttattt ttatttttat ttttagcatt ctgagcaaga tgtaaatatt tgcctcctga 54000 actagggatc tccctatcac tggggtcttt ataaggcagg tagccacatg gctgggattc 54060 agggaaaggg actcaagcat cgaatggggg tgggttggat gccctttgag gtcctggcct 54120 gcctgagcgc ccctggctgt gtgggggttc tgcctgcccc tccctcctca cctccttcct 54180 ccccctcctc ctcccttcca gcaacagatt tccctgctgt ccctccaaca tagagctttc 54240 cctgtgcggc ccctccctct tttcttcagg tatctgctta aatgtcactt cctcagagaa 54300 gccctctctg gcagctctat ctggacactc ccctgaccca ccacgctgtg tcctccctgc 54360 tggttttttg tttgttttttt gagacagggt ctcactctgt tgcccaggct ggagtgcagt 54420 ggtgtgatct ctgcaacctc cgcctcagct cactgcaacc tctaccacct gggttcaagt 54480 gattctccta cctcagcctc ctgagtagct gggattacag gtgcccacca ccacgcccag 54540 ctaattttgg gagcctcagc ctcccaaagt gctgggatta caggtgtgag ccaccacacc 54600 cagccctccc tgctgtttct catagcactc accactaact gcattgatac tatttggctg 54660 tttacttatc atgttagggg ggatgacact tgtcattatt tcatacaatc ccagtgcttc 54720 agttgcttaa cacggcagaa gcaggtcttg cccagaggac attttggtga gggcgtttgg 54780 caggtggcct ttcacaaggt gttcaggggc ccaggctcct gctaatttgt ggctctgcta 54840 tcccccaggg tcttggagcc ccctggcctg aagatgggggg aagagagagg aataggagac 54900 aggaggggag gggagtggagt ggggaaggag ggcaggagtc tgtgggagat ttttatgggc 54960 cagataaggg agtggcttat attactttgc ccacatccca ttggccaaga cccagtcata 55020 tggccatagc caactgccag ggtgactggg aaatgtagtc ctcctggtgt ctagcaagaa 55080 aattaattaa cttttggtga actcctagca gtctcagcta cacttattta tcacatgtca 55140 ttgaatttat gacatcatct attgcaaggg acaccatgat ttctggaacc actaattaaa 55200 ttaaactaag acatgccatt gatttcaggt gaattctgat tgccaagatg gtaaaatgtg 55260 gaaaaatggt acagctcgga gtcaatgaac tatggtattg tctctccttg aggacaggga 55320 cccattcacc ttgctcacca acatattccc agagctgcaa gagtgtcaag catgcagtag 55380 atattcagag aacaatagtt gaggccaggc acactggatc acacctgtaa tcccagcaat 55440 ttgggaggct gaagtgggag gattttctaa gcccaggagt tcaagaccag tctgggcaac 55500 atggggagac catgtcgcta caaaaaaaca aacaaacaaa aaaattgttt aaagacaatg 55560 gtagttgaat gagtgacagt gtgtgagcta ctcttttgtt taagtgcgag aagccccctt 55620 gagtaaacta cagtgtcagg gaatcaggcc atgctcgttc acctgaacag agatgctgca 55680 ggggcatggg aggaattgcc aacagtaact ggggcttcta ggactctctg cctcaaccgt 55740 tccttctctc tgctgccagc ttcgatattc ttctctctca ctgcacatgg gagggaagaa 55800 tgaccttgct cagctcttga gctgtccatc ttactgcctc tgtccctgga gaggcagccc 55860 tgacaccaaa aatctaatgg gagagactca ctggcccagc ttggatcagg agcacaccct 55920 gggtcaataa gctgagccag gaaggcagat ataggatgtc tctaagaata tggcaatttc 55980 tgcaggagct gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtacgtgt acatgcatgt 56040 gcacagaaag acaggcaatg tatgttgggg tcagacgtcc ttcacaggag agaagctagt 56100 gcttggcagt cagttctagc agtgcctgaa tatgggaccc ctttgcctga aaagggactg 56160 tgtcagtgaa agtaacaggc atgcaaatac ataatgaaat gggtgggtgg gaagatgcat 56220 ggatggatga atgacagaag gagagaggga gcaagacagt cttacttgct ttagcattaa 56280 acattttaaa gaatctaaat ggaagctgtc tcctcattac caaataggga tgctaaaaac 56340 aactcttaat atttattaag tacttcctgt atgccaggca ttgttctaag ctcttttctg 56400 cattaactca ctaattccca agaccatctt gtgagatgaa tactacgatg aatactataa 56460 ttcacatccc cattttacag atgacaaaac tgaagcatct agaggttaaa taaccccatt 56520 cataaggggc agagctagga ttcaaaccca aacagtccag ctctaaccac aaagctctct 56580 ggcccagcgc catggctact atgaggatta aagccatctg gaggctactg agtgtgttca 56640 atgacagtaa ttgggttata tatatgtttg agatggagtt ttgatcctgt tgcccaggct 56700 ggagtgcaat ggcgcaatct tggctcacca caacctctgc ctcctgggtt caagtgattc 56760 tccttcctca gcctctggag tagccaggat tacaggcatg caccaccatg cctggctaat 56820 tttgtatttt tcgtagagac ggggtttctc catgttggtc aggctggtct cgaactcccg 56880 acctcaggtg atccgcccac cttggcctcc caaagcgctg ggattacagg tgtgagccac 56940 tgcacccagc catgaggtag gatatttatg ccacatcact gcttgatata gagtgaaaat 57000 aaaaacagat ttaagaaaag ttaagctaaa tttacagatg tcagaactcc aatagctact 57060 gaaaagaagg atactagagg tgagtttggg ggcatattct gaattttcga tgtccttccc 57120 tcaaacacac ccctttgtgg tggtcagagc ccagagctgg ccaaggctag gtggactaaa 57180 gtgagagcta ccaggtacca ttgggccctg cataaggaca cttgactgag aggacccaag 57240 ggagggctga agtttcaaaa agccagcagt ggccactctc cgtgagcctg agctcatgtg 57300 tgctgggctt ggccagtgaa ctgggatctc ccagctgtcc cagggcagcc actctgcctc 57360 caattgtctc ttcctgcctt ggtagagcct ctctcttctc attgtgatgc ctgcagcctg 57420 gaaaatcatg gataaaaagc cctgattgaa aggcactaat tacccattat tattttccat 57480 gccgtaattt gtgcggaatg agatttcaat cagttgtcgg ggatcagcct ggttttgact 57540 aatctttcta acgacaagat gcttaattac agatttttgc ctgagctcca gagcgtgcag 57600 agggaggcaa ctctcgctga agccaccatg ctcttgggtc atcctgcagc cctgggtccc 57660 agagggcccc caaggggaga aagagaaaga aatcattagg aaaatattcc caaggaggcc 57720 aaataaaatg gcaccaccac agagacgggg ctgtgttagc aacatggaca tagagggtat 57780 tggggggctg ctttctaagt caactcatcc tccagaacag gtcaccactt gctgtgtctc 57840 tattgccccc atcagcccca gcctccccca aagcagcctg gcattctagt tagtaagttt 57900 gagcaagtca ttagtttctt agggctgttt tattatctga aagtcaccag ggtagtcaga 57960 aaaatctctg agaacttatg attcagtgac tccagctgtg ctgaagtgtg tgtccagaaa 58020 agtgttacct attgttgaaa gctgaaagat acacataccc aagattcaat cacacaggag 58080 tgattaaaaa aaacaccatc tattaataaa ataggcagtt caggccgggc gcagtggctc 58140 atgcctgtaa tcccagcact ttgggaggcc aagacgggtg gatcacctga ggttgggagt 58200 tccagaccag cctgaccaac atggagaaac cccgtctcta ctaaaaatac aaaattaact 58260 gggtgtggtg gctcatgcct gtaatcccag ctactcagga ggctgaggca agagaatcgc 58320 ttgaacccgg gaggtagtgg ttgtggtgag ccgagatagt gccattgcac tccagcctgg 58380 gcaacaagag taaaactctg tctcaaaaaa ataataaaaa taaaaataaa ataaaatagg 58440 cagttcagat tactcagagg gaaggtcaat ttgaattgat gaaaaatctg agtttaagtt 58500 ttatgtgtgt gtgtgtgtgt gtgtgtaatt aatggatctc agtgcacaga attggattct 58560 tcattatcgc tggttcgtaa cacttaacca ttggcctact tgccccttcc ttccttcctt 58620 cctgcctgcc ttcctgcctt cctgccttcc tgtctgcctc ccttccttcc tttcttcctt 58680 ccctaccctc cctcccatgt aataagtgcc catgaatcca tattcaacag gaaaactgga 58740 accttgacag taattcgcat ctagccacat ggtcctcccc atcctaccct cctgttaggg 58800 gcattctgca atctttaata ctattttaaa ggaaatttag ttacagtata gtagttctag 58860 gtgcctgagg ggctgatttg tgactcataa agccttgctg gagggtctga ggatctgctt 58920 taatggatag ctcttgatgg cccctggtta gcaaattaat tattgaaatg tacataagaa 58980 tctctcaagt gttcagaaac catttttctt ctgtggagtg gattcccatg tcagttttgt 59040 ttatcctctt aatttgccca gccagcttct ttccctcctg gtctatggca agttccttga 59100 agaatcatcc tcaattctag gtctgggggc cttggatgag ggaaggggtt tgctgggttt 59160 aaccacaggc ctgcccactg ctggactttc tcagaagaat cacagcctca ggcaacatcc 59220 actgagtgcc tgcttgtcac ctgcgctgtt ctaagcattg tgccttcatt ggctcttgct 59280 caactctgtg aaggaggtgc tgtgattgag cccattttac agatgaggac cctgaggtcc 59340 agagaggatg acctgattac tcaaagccag cagcaattag ggatagaact ggcacgtctg 59400 ctaccagcat gcaggcttgt agccattaag tggcccagct gcttgttcca gttcttaaat 59460 gcatggcccc agcagggatg aggctctggg ggccgtcctt cagcctgacc cagattcttg 59520 ggtgtggtgg gtagattcta ccccatagag gaaagcaagc tggacgctta tcaggccagt 59580 ccattcctct gcctgctgcc ctctgaccag cagcaggcca cctagtgtgg gaaagatcct 59640 tgagattcca gcgtaaaaaa cagtgagagg ccgggcctga tggctcatgc ctgtaatccc 59700 acatttgga aggccgagga gggcaaatta cccaaggtca gggatttcgat accagcctac 59760 ccaacatggt gaaacccgtc tttactaaaa atacaaaaat tagccaggca tggggggcaca 59820 cgcctgtagt tccagctact caggaggctg aggcaggaga atcacttaaa gctgagaggt 59880 gggaggttgca gtgagccaga tggagctact gcactccagc ctggatgaca gaacaagact 59940 ccatctcaaa caaaacaaaa acaaaacaaa acaccgatga tgatctcttg ttgataccct 60000 gaaatctgtc ttcctctaga agtctaaggc aaaatagttc agcaatttga gtttcattca 60060 gaacttttga gattcccctg ctctctgcat taggaaaatc ttcaacctgc tttgtaatcc 60120 agcagagcaa tgtccagcca aggcaggaag agccccccag caagctcggt gtcccctggg 60180 gatcaggctg cgaagggaac agggtcccac gctggctact gagaaggccc agggcagaga 60240 tgagttgggg cacgagggag gccacgttta atcagatggg ggtgaaattg aggccagggc 60300 agcgcttgct aagctccagt taggagatga atcaaaggga aaatgatgcc ccaaggggct 60360 tcgaccactg actactgccc tttcaaaggc tgcttggatg ggcgtctgtt ccctccccat 60420 gaagagtcaa tagttatcga tccagtgggg aactgggtcc cagccaacca cagatgatgg 60480 acttgacact ccccgctcct ccccagaaca caagggtcag ctgcctcctg cctcatcctg 60540 cagcagctac tcctcctaga caccggcttg gccaccaccc catggccacc tgtgaaatct 60600 gaagtgccag tctcaggcct agacgccgtc tcccaacctt ccagctttct tgcttcttcc 60660 tcctgctgga cctcagcctc agcctcccgg agaccaccat tgccgcctct ccattttctc 60720 ccaatcccgt cctttctgac atcactccct tgtccaccct cttccctcat acttctaagt 60780 cagtggttct cagcagtttt gctcccaggg agacatttgg caatgtctgt aggttttggc 60840 tcacatactt gggggcaggg tgctacgggc attgagtggg tagaggccgg gggtgctcct 60900 gagcatccag cagtgctggg acagccccat cacatggaat cactcagccc cagatgttag 60960 tagtgccgag gatggaagcc taggtctcag ctgctggaga tggggcccgc ttgcattgtt 61020 gcaccagcat catgagttaa gaggcctgga gaacctttgc gtcccagatt tctgctccca 61080 ctttgtccca cagttactat tgcaaacttc cctccttctc ctagtcctcc tgccctccgg 61140 cccttgcctt cactccctgt ccctcctact tcacagagtc actgcaggct gagtggaggt 61200 ggtgtgggtg ggtttggggg gtaaagaggg cctcactcaa tgcccccctc tgccacctac 61260 aaacttctca tctgtacagc caaccttccc tctcactctt actgaataag ctatttctct 61320 ctctcttttt tttttttttt tttttctgag acggtgtctc gccctgtcac ccaggctgga 61380 gtgcagtggc acagtctcag ctcactgcaa cctccgcctc ccgggttcaa gtgattctcc 61440 tgcttcagcc tcccagtagc taggactaca ggcgcatgcc accataccca gctaattttt 61500 gtatttgtag tagagatggg tttttgccat gttgaccagg ctggtcttga actcctggcc 61560 tcaagtcatc tgcccacctt agcctcccaa agtgctgaga ttacaggcat gagctaccac 61620 acccggctgg attccttgca aactcttaca agatcctctc atgatggcat cacttcttcc 61680 agtaggaccc cacccttaag aatcacaccc ttaagaatca acacccttaa gaatcacagc 61740 tgcaccacca aaaccaaacc aaacctccct gtagatttct tgggccctgc ctgtagagac 61800 gcttcttcaa aatatgacgt cagtgggatc aggtctagga agccacctgt tcaccaagcc 61860 cctcagctgc ctccgatgaa gattgaagta cagtttgcaa aaagctgaca cgtattttgt 61920 gtcttcagcc tttaagtgtt gattttgccc tctaccacta atatttaaca tcgggtagcc 61980 atatgattca tgatctactt cagggagaga agtgggggcg gtgatggtaa tgacactgga 62040 ccagcagtag gaccgagatt gctcagggcc aactgggagg tatcgatacc taatttttaa 62100 atgtcttaaa ttccttacat tctcaacacg cccccttctc atcaaagaag ctgacaatta 62160 gtactgacaa cagtaacaaa acattccttc cccacgtcac agcctccaag tccaggaggg 62220 catgctttgt ttacaaggta gctggtgctg cctgaatgtg ttcatgaagg cacccctgct 62280 ccgcccagtc ctctaccctt cacggccaat tttcctgaaa gaattgtctg cattcactac 62340 tttcagccat tgcaatgagg cttctgtccc catcatgcag taacctggct gtggtgaatg 62400 tccccagaca cttcctgact gctaagtgta gggatacttg ccccttctca ctctcactcc 62460 acctgacctt ataggatgga atctgctgcc caccgccctt ctagatggct ctgctcatcc 62520 aatttccatg acatgctcta ttttttcctt ttcccacacc tctggttaca tcttctctgt 62580 cttcttggac ttctttccct ctgtcctgcc tttacatttt tttttttttt ttttgagacg 62640 gggtctctgt cacccaggct ggagtgcagt ggcacaatct cggctcactg cagcctctgc 62700 ttcctgtgtt caagcaattc gcctacctca gcctccccag tagctgggat tacaggcatg 62760 tgccaccatg cctggcgtga gccactgcac ctggcctgcc tttaaatttt tcattcgaat 62820 gaatgaacac atgaggtcct gggggataag gacagatgga gggagtgggc aggtctccca 62880 gagggtctgg cctctccagc aactttcttc cccctgcctg gtgcatcagg aaccaggcag 62940 cccagagagc actgtgcctc tctccccctc tgcttccaga gagttctcta ttctgacact 63000 ttataggtta agaaataaca gcgaagctgg gggtggtggc ccatcctgta atcctagcac 63060 tttgggaggt aaaggcgggg gatcacttga ggtcaggaat ttaaaaccag tctggctagc 63120 atagcgaacc cctgtctcta ccaaaaaaaa acagaataca aaaattagcc aggcgtggag 63180 tcacgcgcct gtaatcccag cctctcggga ggctgaggca agaaaatcgc ttcaaaccaa 63240 gaggcagagg ttgcagtgag ccaagatcgc acacctgcac tccagcctgg gcgacagagc 63300 cagactctgt ctcaaaaaaaa aaaaagaaaa gaaaaaagaa aaagaaaaag agcagtgaca 63360 ggattccagg gtttggaact ctgggtggca gtcagacatt gtctgcattt tgggggattg 63420 gaaagatgag gtccctgcct ggagcagctc ttgcccaggc ctggtagcag agaggcagag 63480 tgctgtgaag caaggaacgt ggacctgcag tcaggttcgg actgcagctt ctcccaggac 63540 tcaagtgaat gggataggct ctgagctccg gccttttcct tctcccagga ctcaagtgaa 63600 tgggacaggc tctgagctcc agccttttcc ttctccgagg actcaagtga atgggacagg 63660 ctctgagctc cagccttttc cttctgtaag gtggggatag gagggcagag cggacaggct 63720 gtgaggatta aataagatgg cacggaagaa ggtgtctcac atgcagctgg ggcctgatgg 63780 gcagccgcta gtatcgccca gcctctgaga ggggaagctg ggcagctcct gagagtgagg 63840 aaaacatgca gaagagcctg gaaggaattt caacccagaa aagaagctgt ggccctctgg 63900 gggtcttcat atagtgtgaa aatatgaaga atgagagaat gaatgaagca agaccagagg 63960 caccgcagca gtgcccccat cagcatggca cccgcggggc cctttctggc actctgtgca 64020 cttgtgttgg cttagtgtct gttgttccta tgaaagtatg agcgtcttga gatcgtgagc 64080 tgtgcctgtc gtgttcccat tatctggcca gcacttggca catagtaggt gcaaaaaata 64140 cacatgaca gttcctagaa aaggcatgct gaggaggcca aaataatagt tatggaaatg 64200 aggcggggtg tggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 64260 atcacctgaa gtcaggagtt cgagaccagc ctggccaaca gggtgaaacc cccatctcta 64320 ctaaaaatac aaaaattagt cagtcgtggt ggcgggagcc tgtaattcca gcttctcagg 64380 aggttgaggc aggagaatca cttgaaccca ggaagcagag gttgcagtga gccgagatca 64440 cgccattgca ttctaggctg ggtgacacag tgagactccg tctcaaaaac aaaaaacaaa 64500 acaaaacaaa aacatggaaa tgagaaagct ggaggactaa aattactaga tcctcctgag 64560 ttgggactca ggctctaaat taatagcggg cttcctgtac caaccctgat agttaataac 64620 gggcttcccg caccaaccct gatagagtta atagcgggtt tccctcacca accctgatag 64680 aggccagcat cttctttgct tccctctcag ccctgagggt cttcatccag ggcctggagg 64740 tggggcccag acactgcagg atgcaggatg ctttgcaccc ttctgaatca aggaggggag 64800 cggaagagga aaccaaggct tggggagcaa accgccgcct gctctggtgt ccttcagggt 64860 tgtccagcca tgagacgggt gcagggaggc agttgggaaa actgtggcct gccctctcct 64920 gggaggggct gggagctttc catttacttt ccttggggca aatgcctctt atccatcaag 64980 gcacagatct gaaacaggtg acacagagta cttggtcact acatcatcgc tgctgtaatt 65040 actgtttatg tcaagtgtat ctcctgagat ctctggagcc ctctgcagcc tggggaaggt 65100 ttgggctgaa gacccctggg atctgggagc tgtgttgctc agcagggttt ttcacagtgc 65160 cctagggtct tcctgtgaaa agcaaaacct aaagcagcca tcaggaaagc aggaggggat 65220 taaaagttag gatgtggtca gctctattct gcctgcctcg tggaagggtg cctgaggagc 65280 aaggtgcgcc cctgttggct catcacatgc ccctgcagct gatggcctgc caggctgatg 65340 gtctttcctg gggactccac tggtggttgg gaagaaggtg tgtggcagtg cccagggaga 65400 tgatcacaga gatgtagaag ggcctggagg agattctcaa ccaggggact ggggcttata 65460 ggagagtgtc tccgaggact cagggacatt ccacaggaaa cagaagagac ccaggagtct 65520 ctgtcttcac acactgcatt ttgggagttg gtgaacttct ggagagtagg agctttatgt 65580 tatcttttat ctttgtgtct gtagctccca gcttctggtc tatgggaaag tgagttcctt 65640 gactccagcc atagtcaatg gcagcccctc aggaggggct aattaattaa ttaatcaatt 65700 tttgagacag agtcttgctc tgtctcccgg gctagagtgc agtagcccga tctcggctca 65760 ctgcaacttc tgcctcttaa gttcaagtga ttctcgtgct tcagcctccc gagtagctgg 65820 gactacaggc cggcgccacc atgcccggat aatttttgta ttttttgtag agacgggctt 65880 tcaccatgtt ggccaggctg gtcttgaact cctgacctca cgtgatccac ccacctcagc 65940 ctcccaaagt tctgggatta caggcatgag ccaccacgcc cagccaggag ggcttaattt 66000 gtattaatca ttaatgagac cagggacagt ggaggcctct cccaatcata aggttgcaca 66060 gacacatttt gtggcattgc tatttggcca tgggttgcaa gatgcaagtg ggctctgtgg 66120 gtgtgataag agggagac agaccctccc tgccacccaa gagtcgtctt tccattggca 66180 ggctgtccta tgacctccct atcctttgct cctctgcaag atctttccct ttttcctttc 66240 acctgctcca ggcataagca tgagcctcct ctctacctcc atagggggag gctcagggag 66300 tgaggcagcc tgtcaaggac agggacagat caacaccacc caggccaccc tcagacccaa 66360 tcctggctgg aatgtgaccc acagctgggt ttccctgaac acacacctta atctcccagg 66420 tgtgagctca gctgtctttc ttgtccatgt tgagagaaga acaagtcctc tcccttcatc 66480 ctgggagctg ggatacggga ggggaacacc cttgcccgcc ttctcctcca ccagcatggc 66540 cggggtggag gggcttggtt tacaggaaac attctgttat cccacacagt gatcttgcca 66600 tactggtaat tcacctggac tttgtgggtg ggtggggagg ctcagtgggt agaaatagct 66660 gggggatgct cagggttggg gttagaatgc tccctcaagc tttccagtgg agacatgtct 66720 cttgggggac aggcaggctg ggtagaagct ggctactcgg ggtctaggaa gggaaatgag 66780 agagggaggg tttgggagcc accttccaga catgccttct ggtaccaagc ctggaccagt 66840 ggcaaaaccc aaagggcagc caatctggct ggtacctttg ccacaggatt ccttcttgaa 66900 tcagccaaat aacctgttgc ctctggttcc gatcttagtg aaggtagggg tcccagggaa 66960 gctccaagcc aggtcactgt acttagtctc tgggccaaag ctgtactgcc aagactgtta 67020 cattgtagcc attggctggg tgcagtggct cacacctgta atcccaacag tttgggaggc 67080 cgaggcgggt ggatcaccta aggtcaggag attgagacca gactggtcaa tatggtgaaa 67140 tcctatgtct ctattaaaa tacaaaaatt agctgtgcat gacggcgggt gcctgtaatc 67200 ccagctactt cggaggctga ggcaggagaa tcgcttgaac ccaggaggtg gaggttgcag 67260 taagccgaga ttgggccatt gcactccagc ctaggcgacg gagcgagact ccatctcaaa 67320 aaaaaaaaaa aacttgtagc ctttgtgtat tattgttatg caggaaggtt ggccaaacat 67380 tttggctgac tagtttccat cttgtgtcac cctcaaacta gaaatttgca aagcactagg 67440 gtgcctaatc tgaagatttt ttgtttgttt ttgagataag gtgttgctct accacccatg 67500 ctggaacgta ggggtgcgat catagctcac tacagcctta aactcctggg ctcaagcaat 67560 cctccctcct cagctcctga gtagctggga ctacaggcat acaccatcat gccaggctaa 67620 tttttttttt ttttaacaga tggggtctcc ctatgttgcc caggctggtc tcaaactcct 67680 ggcttcaagc gatgatcctc cccgctcagc ctctcaaagt gctgggattt acaggtgtga 67740 gccaccacac ctggtccgct gaagtttatt gatcaaaata aagtttcttt gaggcctccg 67800 aaggttttgg aggtaatgcc agaaacttgc tcccggctgc gccgagggga gaccagctga 67860 ccttctccac cgttgtttta tcgcaccaaa gccttagcat agagcccttc ccagccaccc 67920 tacctgcggg gctggacccg cccaccacac ccacagcacc ttgctggggc tgacttcccg 67980 atttgtgtcc acaggctgct gaacaggatg tcctcggacg acaggcacct gggctccagc 68040 tgcggctcct tcatcaagac tgagccgtcc agcccgtcct cgggcatcga tgccctcagc 68100 caccacagcc ccagtggctc gtccgacgcc agcggcggct ttggcctggc cctgggcacc 68160 cacgccaacg gtctggactc gccacccatg tttgcaggcg ccgggctggg aggcacccca 68220 tgccgcaaga gctacgagga ctgtgccagc ggcatcatgg aggactcggc catcaagtgc 68280 gagtacatgc tcaacgccat ccccaagcgc ctgtgcctcg tgtgcgggga cattgcctct 68340 ggctaccact acggcgtggc ctcctgcgag gcttgcaagg ccttcttcaa gaggactatc 68400 caaggtgcgt ggtgggcctc aaggagcctg ggcgcagggt tgggggtggc agccgtgcct 68460 gcgggtctgg cagaagccct aggaattccc agagactgcc aattctgggc gctgttggag 68520 cggtacttct gtggggcgcc ttttcccttg ctcagggctt ctcattctgg cactggacag 68580 ctgcaagact gttgttgaga tgacacgcgt tccccacccc ctcagctccc ccatgcacag 68640 ccccagaaaa ccaaaagaaa atccacagga atgccaaacc ctgggtgctt ctcactggta 68700 tggagtacac tgtcaaatgt gtgtccctca aaaagtttat tttgtgcggg ggaaaaatat 68760 aatttgccct gcaattccag acttacggga catagaaagc gtccctcacc ttgtttttgt 68820 cttacttata caagtaaaac gccagatgtg gtgactcatg cctgtaatcc cagcactttg 68880 ggaggccaag gccagaggat aggtcaagcc aggagttgag accagcctgg acaacacagt 68940 aagaccccat cattattatt attattttta aattaatgca tggtggcaca cacctctagt 69000 cccagctact tgggatgctg aggctgcagt gacctgtgat ggcaccactg ccttccagcc 69060 tggaagacag agcaagaccc tgtctcaaaa taataataat aatatatgag tattttctca 69120 ctgtagaaga ctcagacctg ttggaatcag gacaggagct catcctgtct ggatcccagt 69180 ttaacctatt tttaagaccg accttccttc attccttcct tccttccttt cttcctccct 69240 tcctctctct ctctctcaac ccatcctgtc tggatcccag tttgacctat cttttaagac 69300 ctgtattttc tttccttcct tccttccttc cttcctttct ctctctcact ctctttcttt 69360 ttctttctct ctctctttct ctctctctct ctctttcgat gagagtctcg ggccaggcac 69420 actggcttaa gtctgtaatc ccagcacttt gggaggccaa ggtgggcctt gaggtcagga 69480 gttcaagact agcctggcca acatggtgaa acccccgtct ctactaaaaa taccaaacaa 69540 acaaacaaaa aatcagccgg gtgtagtgtc aaatgcctgt aatctcagct actagggagg 69600 ctgagacagg agaatcgctt gaacccggga ggtggaggtt gcagtgagcc aagattgggc 69660 cgctgcactc aggcctgggc gacagagtga gactccatct caaaaagaga gagagataag 69720 ggtcttgcta tgttgcccag gctggagtgc agtggctatt cataggcaca attattgcac 69780 actgcagcct tgaactcctg ggctcaagcc atcctaccat ctcagcttct caagtagcta 69840 gaacgacagt cgctgccacc acacccataa gctttttatc aatacatttg catatcacct 69900 gagtcacatt ccaatggcca tggtggtggc accctctttc tgtgggtact agagtcaatc 69960 actctgacaa aaggcgtgca agaaccctgg tgggtcgctc tgtaaagtca ccacgaggtg 70020 aattggggag aataaattgg ggagaatggt gggcctgccc ccacagggct gttatcaaat 70080 tcatggcaga gagagaccac tgggaccact ggtgcacatc accacaccca gttaatttta 70140 tttttaatag agatggagtc tcaccatgta gcccaggctg gtctcgaaca cctgggctca 70200 aatgatccac ttgggcccac tttggcctcc caaagtgctg ggattacagg cctgagccac 70260 cgtgcctcgc cgatagctgt gactgttaat tgcgtcaggc cctgggtaga gcactttcat 70320 tcagttagtc aagtatctgt tgagcaccta caaagcacca agccaggctg taggtgctgg 70380 tgataggata gacaaaatct ctactcatgc aggtcactgc gatgagctgg tgccatccaa 70440 ctggcacaga aactgcagac cagacaggag aacacccagg aaccacccat cctgcccctg 70500 catcagatcc ctttccaggg ccctgcctca ctgtccccag aatgtaccta ccccattcat 70560 ttccctttta gaagaggcag gctaagcttc cccgggatga ttctgtttat tcaacaaata 70620 tttatgtgtt taagtttctt cagatggcaa tctatttatg aaaccaattg aagacattaa 70680 gattggatat atttccactt ccacatatga gttgagatgg tgtggtgcat tggctaacca 70740 tcagggctcc tggtcagaga gttccatcgt ccccttatag ctgcaccttg gacatgctcc 70800 ctgtttctct ctgtgcttca gttacttcat ctaaaaagtg agatatcagc tgggcgtggt 70860 ggctcacgcc tgtaatccca gcatttcagg aagccgagga gggtggattg cctgagctca 70920 ggagttggag accagcctgg ccaacatggt gaaaccctgt ctctactaaa aatacaagaa 70980 ttatccaggc atggtggcag gtgcctgtaa tcccagctgc ttgggaggct gaggcaggag 71040 aatcccttaa acccaggagg cagagggtgc agtgagccga gatggcacca ctgcattcca 71100 gcctgggcaa cagagcaaga tcccgtctca aaaaaaaata ataaaacttt aaaaaataaa 71160 aataaaaagt gagatattgt tcctacctta tagagctgtt aagaagctta cgtgagttaa 71220 tatatataaa gcacttagaa tattgcctag cacctagtaa gtgccaaaca aatgtttgta 71280 attattattt taactttaac aatgtgattt aagacatatt attatgaaaa caacggacac 71340 atttatctta tagaataagc ttttgtaatc tacatatatt taaataaaac aataattgtt 71400 ttgatctaac aggactcaga ttattttagc tattttagtt ataaatttct tttttctttt 71460 ctttttttttc tttttttttt ttttttgaga cagagtctca ctctgtcacc caggctggag 71520 tgcagtggca tgatcttggc tcaccgcaac ctccacctcc tgggttcaag tgattctcct 71580 gcctcagcct cccaagtagc tgggattaca ggtgctggcc acaacacctg gctaattttt 71640 tgtattttta gtagagatgt ggtttcacca tgttggctag gctggtctca aactcctgac 71700 ctcaagtgat ccacccgcct cagcctccca aagtgctggg attacaggca tgagccaccg 71760 cgcccggtca taaagtgatt tatttcttaa atgagccctt ttaaaaaaat aaacatgata 71820 aaaaaaattc tagcagtgca aaacagtaga gcacgttttc ctgaaacccc agacctcagt 71880 tttcttaact atcccagaag gaccccttta ccatctttgt caagcaaata ttttttgagc 71940 atcgtcttta tcaggcactg tgctggcctc caggacataa aaatgaatgc accctggtct 72000 ctgcccgctt tatacaccct gagtctgagt ctgggggaag gccctgggat ctctgtattt 72060 gaaaagcact gcatggtgat gctgtctctt gcctcagcca agaatgagaa cctccagtat 72120 gatggttttt acacaaatca tcagatattt gacaaacaca aaatgtttaa gtcaactgaa 72180 gttaccaaga taacaacatt tttctttcta aattggaagg ttgtcttgga gaggttgcca 72240 ttattttaga ctctttgagg tcagtttttg aagaattgct tgttagaaga cagtcacatt 72300 ttcttctcac catgttgttc tagatgggc tggagagttt tgaatcacat tttttgaaag 72360 cagaggttaa tgtgtgtaaa ctcagaaatc ctactgcatg cttgacagag gcccaggtgt 72420 ctgcgaatgt tctcagcaag tcaggagtcc acatgaaaga ttcgtaaata gtcttaatta 72480 tttgctaccg cgaataggat aatgatctct tcgtagaagt caaaagacaa acagcagcat 72540 ttgtgcagtt ggaactgaac tgctgcagcc tcttctcttt ccacaaggag agtttcaagt 72600 tcgtaaccag aaagaggttt atattcagga cagggaaaag taaactcaag gctgacagat 72660 tgctgtggtt attttattaa ctctttggtt ttgttctaac aaagatttag gttttgttgt 72720 tgtttttttt tttgagacag agtctcgctc tgttgcccag gctggagtgc agtgatctca 72780 ctgcaacctc cacctcccag ctcagcttcc caagaagctg ggattacaag cctgtgccac 72840 cacacccgac taatttttgt atttttagta gagacggggt ttcgtcatgt tggccaggct 72900 ggtctcgaat tcctgacctc aagtgatcct cccaccttgg cctcccaaag tgctgggatt 72960 ataggcgtga gccaccatac ccagccagat tttgttgttt ctaaacgtag caactgtaga 73020 acatctggaa aactaggaaa agtacagaca ggagaaaaat gacctagaat tggacaacca 73080 cagagacaaa ctcagaactc agtgagcatt ctttgagtcc ctctctgagt aaggtgcaga 73140 gggggagcag gagagaaagg gacgtggttc tttccctaag aagctggaat ctgttgtggg 73200 tttttttttg ttttgttttt gtagagatga ggccttgcta tgttgcccag gctggtccca 73260 aactcctggc ctcaagcaat tctcttgcct cagcctctca gagtgcttag gattagaggg 73320 aggagccact gcgcctggcc caggtagctg caatctactg cttagtgccc atgagtctac 73380 aggcgtagca ctgtgctcca aaccaggaca tagtctccta agcacctaat attcaggtca 73440 ttttttttaa gttctattgt gtggacagag ggcttaagtc atggaatgag ccattcacga 73500 gtgcctgtaa atgcttggaa agctctgaaa attgggccag gtgtggtggc tcctgcctgt 73560 aatggtagca ctttgggagg ctgaggcagg aggatccctt gaagccagga gttccagccc 73620 agcccagctt gtgtaacaaa gcgagaccct catctctaca ataaattttt taaaaattag 73680 ctgggtatgg tggctcgtgc ctgtaatccc tgcttcttgg gaggctgaag tgggaggatt 73740 gcttgagccc aggagtttgg aggctgcagt gagctatgat cctgccacta tactccagcc 73800 tgggcaacag agctggagtt tctttaaaaa aaaaaaaaag cggccgggtg cgatggctca 73860 cacctgtaat cccagcactt tgggaggcca aggcaggtgg attacctaag atcaggtgtt 73920 caggaccagc ctggccaaca ggatcaaacc ccgtctctac taaaaaatac aaaaattagc 73980 tgggtgtggt ggcgcatgcc tgtaatccca gctactcgag aggctgagac aggagaattg 74040 cttgaacccg ggaggcagag gttgcagtga gatcttgcca ttgcactcca gcctgggcaa 74100 caaaagcaaa actccgtctc aaaaaaaaaa aaaaaaaaag aaagaaagaa agaaagaaaa 74160 gaaaagctct gaaaatcatg ttaatcgtgt tacctcacac cctgcctctt ccttagatca 74220 cttccttctg cgcaatccaa tggttgtact aatatgggaa gaaattttgc agaaacaaag 74280 atgtcatgat agatttaggg agaaagacta agaccgagtc attccttctc caccaatctt 74340 tttttttttt ttttttgaga cagagtctcg ctctgtcacc caggctggag ttcagtggag 74400 cgatcctggc tcacttcaac ctcggcctcc caggcttaag caattctcct gccacagcct 74460 cccaagatag ctgggattac aggcgtgtac caccacaccc ggctaatttt tgtattttca 74520 gtagagacag ggtttcacca tgttggccag gctggtctcc aactcttgat ctcaagtgat 74580 ccacccacct cagcctccca aagtgttgga attacaggcg tgagccactg cgtccaatcc 74640 accaatcttt attgagccct cactatgtgc ttggctggta gtacaatggc gggggaggga 74700 agagggggaa gatgggcaaa ctacggcctg taagccagcc acccttggtt gtataaatca 74760 agttttgttg gaatacagcc acacctattt gtttgtatat tgtctatggc tgcttgagcg 74820 ttacaacagc agagctgagt agttgcaata gtgacggcct gatccacaaa acctgaaaca 74880 ctcctctgca ctacattgaa ctaggcagat tcagtctcct ggctctcaga gacctataat 74940 caactcctag tagtgcatgt tagtgtttat tccaaccctg cccaattcta tgctatgaaa 75000 gggaggtttt tttctgttgt tcgttttttt tttttgtttt gtttttgttt ttgtcgctgg 75060 gggctgtgat gacactcact gagaatagat gagctcatag acagatgaag gcaccttcct 75120 gaaggaacag aatggctcca agtcagaaga gatagacctc aacctgattg catttactcg 75180 catatctaaa gaaaaaaaaa tgccaattaa caaggattgg ctagccctgg aggcatagaa 75240 aaaacagaca tacttaggca aagccaccac tcctaggaaa agggagtctt agcctaggga 75300 cagcctgatg tgattaaaca ttccgtttat ctgattaata tctttctggt taggatctag 75360 ttcccctgca ggtcttctgc aaggagtgaa tttgcaggtc aggcagacag atcaatttct 75420 ccttgtatgt gtgctctctt tgcatggcat ccctgagctt atacatcagg ttcctgaatt 75480 taggcaagag gagtgcctct gagagatgga gccactttct gtggctggaa aagtcagctg 75540 cttctgggac ttagggctga gtgacactga ctccaccgta atgaaaacct ttgtaataac 75600 cttgaccctg tcaccctgtg tctctctcag caatgactct gcctcctgtt ttattgagaa 75660 actagaactc cctcagcttc ctgccgccaa accgatgcac tctcttccat gttcgcagct 75720 gcttccgttc actgattccg cagctatttc ttgcaactca ctcactgctg gaagagatgt 75780 ctcctacccc aggctcagct cttctctggc tttgaatcct acctccttcc ctcctcctga 75840 gaccctctcg gctattacct cctctccttt gtcttccctt gctcattttc taaagtctcc 75900 ttccttcctt ccttccttcc ttccttcctt ccttccttcc ttccttcctt ccttctttcc 75960 attaacattc aactatctct agtatctcca atcttgtaaa atatatatct cctctacctt 76020 cagcttcctg gttcttcctc tcttcctcct ctcagttctt gacccagctt ctgcgcccag 76080 catcttcctt ctcatatcca tggcttcagt tgtctctgaa atcaggatga atgctaattc 76140 cataggtctt gctgtcatcc tcttccccaa gctccattcc tttcacacct aatgaacatt 76200 tccacttgga tgccccagaa gcaccccagt tgcacgaagt cttaaacaga agcggttttc 76260 cttccatcac catttctcct tgtgttccca atacagtgcc tgcatcagcc ctccatgttc 76320 aagccagaca cctgggtctt acctttaact ctgcttcctg tcccagcgcc caccccccta 76380 ccaccccgaa ctaacatccc agtggccaag tcttgttcat tctccctcct tcagatcact 76440 tgacccagca gcttgtcttc cttcccctgc ttcagctcag gccaccgctg actcccaccg 76500 cttcctacct gttctccctg ctgccaggct cggccgttcc cagcctgaac acacatctga 76560 ccatgtctcc cttctttctt gtggggagaa tcaaagctcc agaacatggc caaggacgcc 76620 ctctgggatt gccccacgtc tcatgccact ctcttttgca tgctgtggtc accctgattg 76680 ctctgttttc tagttaccag attttattcc atgctttcaa tttctagact ttgcatatac 76740 tcttctctct gttgcaccta ctcccaacct ctactcccag cttgtgtccc ttaggtctcc 76800 agttagtagg catttcctcc aggaaggctt ctctgattct ctcctctcat tcctcctgga 76860 tgccctgcaa aggttcgccc atcacgccac ccttctccca ctgtatggtt attgccattt 76920 tttttgtctg ataccccaag aagagtacaa gctcctaagg cacagggtta catttaactta 76980 cctttttttt tttttttttg agaccgagtc tccctcttgt tgcccaggct ggagtgcagt 77040 gacgcaatct cggctcactg caacctccgc ctcccaggtc caagtgattc ttctgcctca 77100 acctcccaaa tagctgggat tacaggcacg caccaccatg cctggctaat tttgtatttt 77160 ttttttttta gtagagacgg ggtttcacca tgttggccag actgctctcg aactcctggt 77220 ctcaaatgat ctgccagcct cgtcctccca aagtgctggg attacagacg tgagccaccg 77280 cgcccagccc acatttactt cgattttcac ttaaccccat gtcctctcac agtacctggc 77340 atgtagaagg ttctcagtgt gtccaaatgc aatgcaatcc ccaaacaaag tgatctccca 77400 tttcccaggg aggacaaact gaagaagttg ggccagtttg catatgtgta aactttaagg 77460 gatctaggta aaatagtcag atgtctgctt ataacaatat attatttagt tacgcttgta 77520 tattttaaat taccttatgg aaaacaatat attatttttg aaaagttgtt tttctacaca 77580 tattttgtga aggaagtctt atcaaatgaa tctttgatac aaatgtcttt gttttccttc 77640 tctagagttt tttgagtcat ttaacagtgt ttcagtgtgc tgccttcatt tccatcagtt 77700 aattgaaatt ttatgagaat gtatgcgctg ctatccctaa agttttttta ttttaagcca 77760 taagtatacg tcctacacca taaggggagt tcttttttta tttgtgttga cttatgatca 77820 ggatatccac aatgtatcag gtacatactg cttttgacac ccaacacttg taagattatt 77880 ttcctgggaa taactaaatt tgtgttaaat ttctttactc ccaggccagg catggtggct 77940 catgcctgta attccagcac tttgggaggc cgaggcgggt ggatcacttg aggccaggag 78000 ttgaagacca gctggccaac atggcgaaac cccatctcta ctaaaaacac aaaacttagc 78060 ttggcatggt ggcacatgcc tgtaatccca gctacttggg aggctgaggt acaagaattg 78120 tttgaacccg ggaggcggaa gttgcagtga gccaagatca cacactgcac tccagcctgg 78180 gtgacggagc aagactcagt ctcaaaaaaa aaaagaaaaa aaagtttgtt tttatttact 78240 ccctttgtag tgattcactc aggcaaggag cattgattgc ggtcttctta ggaccatgtg 78300 tcttcccaaa ttttagattg ttgttcagta caaagtgatt gacttaatag cacctctgat 78360 gtgagaactt gtaaagactc aaatcataag caattttctc tctttttttc tttccttttt 78420 tttttttttt ttggtccttg ggacagggtc ttgctctgtt gcccaggctc agtgcagaga 78480 catgatcatg gcttactgta gcctcaaact cctgggcttc tgcctcagcc ttctgaggag 78540 ctggaattac aggcatgcac caccatgccc ggctaattta ttttttaaaa aaattgtaaa 78600 gcggagtctc tctatgttgc ctacactggt cttgaattcc tgggctcaag cattcctatg 78660 gccccccaccc tagtgggctt gcattgtagg gggaaagctg acaataaata tgataaataa 78720 tgaagcatgg tgacagactg agacaggtgt tatgaaggag aaaaaacaat gatgagacca 78780 gagagtgact gagaaagggg gggggtctca tttagaagga ggattaggga aggttgtgct 78840 aataaggtga cttttaaagg aagctgaagc tcatcaagga atcctgggac cagcgttcca 78900 ggcagaggaa aaagccagtg tgtttcagga cagcaggagg gccaacatgg ctagtgtcag 78960 tgagcaaagg caaagtggaa ggggctggag aggatgggca aagtctaggg gccatggtga 79020 ggggtgcact tggatttttt tccaggtaga gtagcagccg ttgactaaca tgtgatacat 79080 ggccatgagg ggctgtacgg ttaggtaaag ccagtctgca ctcctccttg agttcccagg 79140 gtagatggcc aactttgcac aggccactgg gagtcttttg agcaattcct gggtctctaa 79200 cttaaaacaa gaaggaacaa gtaagaaaga ggcctggcac agtgcttcct ccattcacct 79260 ggggcccaga tgcaggcttg gaagaaaact cccctaggag aggggaaggg ggatgattga 79320 tgggttattc caccttgggt cgcctccagg tcttttgtcc tggagaatgc agctggcgga 79380 tctggatcct ggatcccggg aggcacaaga caggggtgca gagacaagag caggagaggg 79440 caggagtcag gagctaggtg ctggtcccgg cccagtcact agccaactgg ctgaccttgg 79500 gcaagcaagg actgagttcc tctggcctca gtttcctcat ctctacaaga agagtccatt 79560 aaacccacaa aatgttagct atctgtaggg cactggcaaa tgacagaaca aatcacaatt 79620 cctctttttg gagacacagc caggatgcca gtcagaatgt ggtcagcctg tgacttaggt 79680 gacacataga gtccagagaa ggtttatacc ttctggaggg cagggagggc ttcctggaag 79740 aagggacact ttctcagaag tggaaggtaa acatgcttgg cagcaagaga ggagggggct 79800 cagtggtgga tgatgggctg ggaaaacagc atggcactgg agtgcaccag gcttcacagg 79860 tcatggtaag gaacagttaa gtaaggagtc atatttaaga tttgagggct atttaaccag 79920 gcttagaatc tcagcttcac gatttcttag ttgtatcacc ttgggcaagt gacttagttt 79980 tcctgagcct taatgtccgt atcagtaaaa tgttaatagt tcctgcccct acagtgttat 80040 tgcaaaaatg aaatgagaca tgcatgtgag ggtgtaacta agtgcctggc acatgaaata 80100 aatagtattt gttttgttag ttgtgcttgg caatgggaag tcattgaagg cttctgagca 80160 gggaattaat cagatctcct ttcagcaaga taattcaggc aacaatagga acgatgatgt 80220 ggaagcagga gaggctaggg gctgggagcc cagtgaggaa gcaattttat tttattttta 80280 ttttatttat ttatttttga gacagagtct tgctatgttg cccaggctgg agtgcagtgg 80340 tgcaatctcg gttcactgca gattctcctg ggttcaagcg attcttctgc ctcagcctgc 80400 ccagcagctg ggattacagg tgtgggccac catgcccagc taattttttt tttttttttt 80460 ttttttagta aagacagggt ttcactgtgt tggccaggct gatcttgaac tcctgacctc 80520 gtgaccctcc tgccttggcc tcctaaagtg ccaaagtgca gggattacag gcgtctgcca 80580 ctgcgcccag caggaagcaa tttttttttt tcccccaaga tggagtctca ctctgtcacc 80640 caggctggag tgcaatgtca tggtcttggg tcactgcaac ctccgcctgg gttcaagtga 80700 ttctcctgcc tcagcctccc gagtagctgg gactacaggt gcatgccacc acacctggct 80760 aatttttgta ttttaagtag aaagggggtt tcactctgtt ggccaggctg gtcttaaatt 80820 cctgacctca tgagccacct gccttggcct cccgaagtgc tgggattaca ggtgtgagcc 80880 attacatccg gccacaggaa gcaattttaa cagtgcagtt agggccgtcc aaaccaagat 80940 cagggcaaaa gggctagaag gagaagttag gcttgaggaa ctttcaaaag tggattcagg 81000 ctgggcacag tagctcacac ttgtaatccc agcactatgg gaggcagagg cgggtagatt 81060 acttgaggtc aggagtttga gaccagcctg accaacatga tgaaaccccg tctatactaa 81120 aaatacaaaa attagccagg cgtggtggct ataatcccag ctacttggga ggctgaggct 81180 ggagaatcgc tggaacctgg gaggcagagg ttgtagtgag ccgagatcag gccattgcac 81240 tccagcctgg gcaacagagt gagactctgt ctccaaaaaa aaaaacaaaa caaaaacaaa 81300 acaaaacaaa aaaaaaggtg gattcattat taaaaggata gtgactggat tgtggatgct 81360 aagggaagga ggactcttag atttctaatt taggctacta gggagatggc aaggccatta 81420 gggggaaaac ataaataccc agaaggaaca atttcgtcag ctgggagagt cagggtggga 81480 aggagcatga gataatggat aaagttttgg acatattgag tttgatcagt tcacagagac 81540 cctggagagt ttggaattac agcccagaag caaaatcttg agtggggttt taagtctaag 81600 gagagcctct aagactgtgg ttctcaaagt gtggccctca ggccagcagc aaaggctaca 81660 cctgggagct tgttagaaat gcaaattttg ggccccaccc cagacctact gaatctgaga 81720 ctggggggca aggcccagca atctgattta gcctttcagg tgagcttcat tcaagctcaa 81780 atttgagaac tggtgttcga gagaaagctc tttagaagga gaagggttga gggaccctgc 81840 ggaacagaag gagcatagga ggggccttga aaggagattg aggagtgcca tatttcatca 81900 gttctaagat gcacattttc tccaagtaac atctctgaat tgggctgcct gtcacagtta 81960 ccattgacca ggtgacagcc gttccctggt tgtcactgca ctcaaacgca cctcaaaagt 82020 tgcagagtag gggccagtgg cctgagacaa cagtgaacac tttcttaaca aagcccttga 82080 tagtagagag gatgactctg tgaaaaaaac atgaaaacaa tgactgatca aaaatgattc 82140 agaagagttt gagatgtttt agcaatattt taaccaatct gtttttctcg tattttctct 82200 tatgtatgtg taagaaggct acgggatcaa atcaaatctg aaaaaaagct cttttttttt 82260 tttttttttg agactgggtc tcgctctgtc acccaggctg aagtgcagtg gcacaatctc 82320 tgctcactgc cgcctcagcc tcccttcaac ctccctgggc tcaagtgatc ctccccacctt 82380 gagcctccaa agtagctggt accacagggg catgccacca cactcggcta attttttgta 82440 tttttggtag agatggggtt tcaccatgtt gtccaggctg gtcttgaaca cctgggctca 82500 agtgatccac tggccgtggc ctcccaaagt gcctggatta caggtgtgag cctaatcggt 82560 ggattctttt ttctttcttg actgatgggt aaaataatgg tacatcttac cactgaaagc 82620 atcttagttc attacaaacc aggcgactaa aaaaacaaaa gaaagcaagt actccagagt 82680 tgattaaata cacatagaaa tagtcagaga tgttgcaaga gtccctgcag agagaaggga 82740 gatgaaatct aacaaaatag cctgttttaa gagggtggca atgggtgtct gctgcttcag 82800 gaaggaccag gaggagaaag accaagagga gacaattgca tttggtagct gaaaggtcac 82860 tgttgtggaa ttctaggatt ctctgggtgg gggctcttgc tttcaattcg tttgcattca 82920 ttatctattc aacagatatt aatcgatttc caggattgag atactgtact tgagatacag 82980 aaatgaaaaa cataataatc tccattccca aaaagcacac agttcagaag ggaggcccac 83040 aggtacacct gtgattatga aacactaagg tagctgcttt gagtgtgggg atggggtggt 83100 ggcgagaaac atgcgagcct atctggggca gaagggaaga aagtgtcacc aaggaggcca 83160 tgtgagagct gtggctccaa ggatgtggag gagctggcca ggaggaccaa atgaggagtt 83220 tcaggtagag ggaggtatgg gagggccggg ggctccatga gatccatgaa ctattatact 83280 tactgacagt tcagatctgc tggagcctac aaactggagg cctcagtgag aggggattag 83340 ggtggacaat ttggaaatgg tcagatcata aaaggcctgg taggctttgc cctggagttt 83400 agattttgtt ctctgctctg ggtggcaaga gttggagaat ttcttaaatt tatactttaa 83460 atttatttct aattcttttc aaaataaggt atacaaatag tttaaagagt ataaaagaaa 83520 cataactttt aggccaggca cagtggctca tgcctataat cccagcaatt tgggaggcca 83580 aggcaggcag atcaccagga gttcaagacc agcctggcca acatggtgag gagtttgaga 83640 ccagcctggc caacacggtg aggagtttga gaccagcctg gccaacatgg tgaaaccccg 83700 tctctactaa aaatacaaaa attagccagg tgtggtggcg ggtgcctgta atcccagcta 83760 cttgggaggc tgaggcagga gaattgcttg aacctgggag gcggaggctg cagtgagcca 83820 agattatgcc actgtcctcc agcctgggcg acagagcaag actttgtctc aaaaaaaata 83880 tatatatatg ttttataatg aaggatcaca gtcactggcc ctacccattc tcctcccact 83940 ctaattcaga gttaaccatt taaaaaaaac tctcttctat catttagtaa tattgtgatc 84000 ttatagctat atttgctgac agcaagtttt accttctttc ttgacttgct gttatggaag 84060 atgagttagc tccaattaca caacccatcc caacacacac acacgatcat cccgctgtcc 84120 caatatggta atatcacaaa attttctatt ttgcctgttg ccatttcctt cttgacatgt 84180 ccttgacttt tctcatgggt tgtattccct gttttctgga tcctacctct tcctcttttt 84240 agttctttcc ttctttggga aagcatgtag ttcatgggcg tccttaaaag gtataggaga 84300 ggtaaaatcg gcaatacctt gtatatgtgg aaatgcctct attccatcct ccaaccttca 84360 cattagattc atgtcttggc ttggtacaga attctagttg aaaataatta ttctcagctg 84420 ggtgcagtgg ttcatgcctg gaatcccagc actttgggaa gctgaggcgg gtggatcacc 84480 tgaagtcagg agttcgagac cagcctgacc aacctggaga actcctgtct ctactaaaaa 84540 tacaaaaatt agctgggctt ggtggtgcac gcctgtaatc ccagctactc aggaggctga 84600 gtaggagaat cgcttgaacc cgtgaggcgg aggttgcagt gagccaagat cacaccactg 84660 cactccagcc tgggcaacaa gagcgaaact cgcacacaca cacacacaca cacacacaca 84720 cacacacaca caaaagaaag aaaagaaaag aattgtccat caggatttgg acaccattgc 84780 tgctttgtct tgtagctcct gctgctgcta tatcttgagt cttcaatgcc tgacactttc 84840 tgaggttctg cagtgtggct agcttatttc ttatctggat cccttgcttt agctacctag 84900 gtttctactt tcctcattct ctgagacagt tcccactccc atcctgccag ttattggatt 84960 tttgggatga cgcatagaca ggtgtgctcc atgtgccatg atgggccaga gaacccataa 85020 acttgtctgg gaaagttatt aactgacctc cagggggcag tgtggaggat agattggaaa 85080 gggaaatgga gacaggctag tgcaggacca tggtcgcaag gggtgatgag tgtggaacta 85140 ggactgttgc agaagggagg gagggagcag gtatcaggaa gtaggatgaa aaggatctta 85200 ggggtagata tggaaaaatc caggaggccc cttcatttct gacaggttgc aggtggctag 85260 tcgtcccttt gatgagacaa gggatacagt aagaggaaca ggctggatga ggatgggttc 85320 agtttgagaa aggtgagggc ccaggggacc tccaggtaga cacatcagca ggcagatagc 85380 tataagggca tgagcactgg ctgcagatca ttgccaattt cgtgatagtg gaagccagtg 85440 gcatgaatga gatcatccag ctcatgggtg agggggagga tcgggagagc agagggccct 85500 gggcaacgca gagatgaaag ggatggtccc tgtctccaga ggtgtgtaaa taagggagtg 85560 gaactgagtg accatcaccc cagccctttc acaccagctg aatagagtgg taccatttga 85620 gctctgtcat tagccagcag cctctgagcc cacaggtccc cgagagctat ttgtccgagc 85680 ttagcaaccc ccttcctgag cctgtggcag ggctgccctg ctctctgcag ctgttcatga 85740 acagctgatg gggatgaccc tgggatttcc ttctctccgg gaagcacagg atcaaagaga 85800 gctgatggtg gtggttaccc ctctgcctta aggtcacgga gaagtccagg tcaggttcta 85860 ccagtgcctg cctccttccc acaggcaccg gcagcatcca ctctgaggtc tagggaccgg 85920 aggcagacct taatgttctc aaatatcaca gttggtggct agcctcggat ccaacaccta 85980 gaaaagactt atcctggaat cctttggttg tatctaccct gtaagacaat cttgtccaac 86040 ctgtggccca ggatggcttt gaatgcggcc caacacaaat tcataaactt tcttgtagca 86100 ggatgagttt tttttttttt ttctcatcag ttatcgttag tatattttat gcatggccca 86160 agacaattct tcttcaatgt ggcccaggga agccaaaaga ttggacactc ctactgtaag 86220 atctgcctga atataaaaat aagcagagca gccgtggtgg cctgtttgcc agtgcctgca 86280 cttcactaag acctttgtat gctttctgtc actgaatcta gggaactttt attttttatg 86340 tatttatttt tgagacggaa tcttgctctg tcacccaggc tggagtgcag tggcatgatc 86400 tctgcaacct ctgccttctg ggtttaagcg attctcctgc ctcagccttc cgaatagcta 86460 agattacaga tgcccaccac catgcctggc taattttttt atattgttgg tagagacggg 86520 gtttcaccat gttggccaca ctggtctcaa actcctgacc tcaagtgatc ctactgcctc 86580 ggccacccaa agtgatggga ttagaagtgt gagccactgc gcctggcctg aatctgggga 86640 acttttagat aagaacttta tgagatgggg gctgtaccca ttttacagat taggaaactg 86700 aggctcagag aagttaggtg atgtgcccaa agtggagtct gcacctgtct atactgaata 86760 cactcccagg ttagaacctg gaatttatgc taaccattgg ccatgtccct gtcctgagag 86820 aactcatccc caaaactgcc acacctcagc tgcacgtgtg tgtgctgcca atgtcctatc 86880 cctgttccta cacgctccta ggcccgcctc aagagaccac aggaattctg atgaattaat 86940 ctcatcactt tatcgaggag gcacttaaaa aaattacaaa gcaaggccgc cagcctggct 87000 ttgctggcag ctagccgctg gggccataaa ataaattgaa aggaaccaaa ataaacaaat 87060 aattaggtct ctctctctga cacacacaca cacacacaca cacacacaca cacacacaca 87120 cacaaacaca cacacatgca tgcaggccaa cccctaaagg gtgaagagcc tggttgggga 87180 cttgctgtta gcacttggtc ctcttgtcct gggagagcac cagttccagc tctgcacaca 87240 cacttcctga ctccttgctc tgagcagcag cctgtggcct tatccttcct caaaaagtga 87300 caggttggct gagcagctga gagcaaagca tgggaaaagt gaagagtgtg caaagggtgt 87360 cccaggcagc tggaggtgtg aagcccatgg agagccctgt gagctcctgg cacagtggct 87420 cagagcaggc tggagctgac gggctgggtc ccagtcctta ctgtcccata ccctggattc 87480 tgttcaccct ctcctttttt tttttttttt ttttttgaga cagagtctcg ctctgtcacc 87540 caggctggag tgcagtggcg cgatctcggc tcactgctcc ctctggctcc tgggttcaag 87600 caatccttct gcctcagcct cccgactagc tgggactaca ggtgtgcacc accacacctg 87660 gctaagtttt gtatttttag tagagacagg gtttcaccat gttggccagg ctggtcttga 87720 actcctgacc tcagatgatc tgactgcctg ggcctcccaa agtgctggga ttacaggcgt 87780 gagccaccac acccagcccc tctatcttac agatgagaaa aatctgttta cctccggggt 87840 tgctgggaac atgaaatcct tgggatctgt aaagcagagc tgtggctgct ccctgacaag 87900 cattcgccag tgtgagctcc ccgtgtgtgc gcattgagcg gctgggtgtc ccaggcagtg 87960 ggactagaga ggagctggag taggtggagg aggcagacag atacaacaca ggggacatta 88020 atgggttatc agcagggaga aggagcgcct ccccatgtgg gacctggaga aacagagggt 88080 ggagggagca tagagagtct gttctaagct gcaaagcaaa ggcctggcga cctaggagac 88140 catggagttc cagaaagtga tagttatgca gagcgaatgg agggaatcag cacgctgagg 88200 ctgcagagag agggtgggcc tgggtgggaa cgggccaaat cctccagcgc cttctaagcc 88260 aagataaaag cttgaatgaa ttagctttca tatgtgtttt tctcctttct gtttgtcttt 88320 tgaattttac cgggcttaca tgaatattga aattattccc caagaaacca cccaagccag 88380 aatgctctaa gaaatagggc tagacaaaag caggtagggg tacacagaat cttcatccct 88440 tccccttccc atcgccttcc atcctccagc acagagcatg acctccagct ccctccctgc 88500 aagaaatggg atggggagaa aggtggtgcc tgctggactt gagacaggga gagagaggga 88560 gagggggaga gagggagatg gggagagagg gagggaggat agctagcctt cacctgtaga 88620 tctctgaggt gctccggaaa tagttttctt caccagtaaa aagggatgag aatactctct 88680 gagcctttgt gagtactcaa tacagttagg cacattgagt aattttgcta cctcaaagca 88740 ctttgttaat ggtagaacat ggttcatgct tgtttccaga aaatccaata gaaaaggttt 88800 ccatccatat cccatgtggg gaggtggtga cacagggaag cccaaggcca cccttctccc 88860 ctactaccca ccaggcgacc tcagccgctg ggtcagcacc aggcacctgt cctcagtggg 88920 gcagcacttc caatttcccc atcctccttg tgagatacag ggtgggacag gagatctgtg 88980 tggccttggg taacctgctt cagctcccag agcctcagtt tcttggtcta tgaaatggga 89040 cactgatgtg ccttcagagg ctgttgtgag gactgaggga gctgtgcaga ctatgcacac 89100 agtaggtgca caataaatct tagctgctat tcctctgaag tgggtagggt ttggtgtgga 89160 ggattcagat aggcaagcct ccagctcctc cctgctccct caggaggtgg ggctggaacg 89220 agagatgtgt tctagttgag agattctgtt ctggaaaacc ctggctcagg ctgacctcaa 89280 gcactttggg acaggagtcg aagagacaca ataccaaaac agtactgtga tgtgctgttc 89340 ttcatttgta cgttccagtt acattttttt ttgagacgga gttttgctct tgtcacccag 89400 gctggagtgc aatggcgcaa tctcggctca ctgcaacctc cgcctcatgg gttcaagtga 89460 ttctcctgcc tcagccttcc gagtagctgt gattataggt gcccacccct atgcccaact 89520 aatttttttt tgtattttta gtagagacag ggtttcaccg tattggccag gctggtctcg 89580 aactccatac ctcaggtgat ccacctacct ctgcctccca aagtgctgga ttacaggcat 89640 gagccactgc gcccggccac tccaattgca tttctttacc tccccccacct gctctccccc 89700 catcgtcttt ccctccatta ccaggcacat tgtaggtgct caatgcgtat tcgttaataa 89760 gagtcagcag gtcagatgcc tgtattagaa aggcagtcac agcctctcct gactggactg 89820 tcaaccctcc caggaagagc gctggaaggt cagttcaacc taaataagac ctctgtgttc 89880 acactgcata gaaacacttg gaaaactcat ctgtaaaatg ggaatagtat tagtacttat 89940 tttctctttc atggaattgc tattgggagg ggagggactc tgtagatcag tcattcactg 90000 cattctacct gcctgtctct atattgcggg ggctgtgcta agtgctgctg gacactgggg 90060 agcagcccaa ggtcttggct tcgtggggcc tacagcttaa aagagcatgg gttgggttta 90120 tggtagccat tcttttgttt tgttttgttt tgttttgttt tgttttgttt tgttttgttt 90180 gagacagagt ctcggtctgt cacccatgct ggagtgaagt ggcgtgatct cggctcactg 90240 caacctctac ctcccgggtt caagcaattc tcctatctca gcctcccgag tagctgggat 90300 tacaggcaca tgccaccaca cctggctaat ttttttgtat ttttagtaga gacggcattt 90360 caccatattg gtcaggctgg tctcgaactc ctgacctcag gtgatccacc aacctcggct 90420 tcccaaagtg ctgggattac aggcatgagc cactgtaccc ggcctggtag ccattcttat 90480 aacccatgaa aggagtggcc tgaaaaattt atcacagatt ccctccgctg aatgaactct 90540 gctcataaaa tgaccccctc gcattgaata gtgtttaaag cagttgtcca tatgtggtct 90600 tggttaattc ttcatttagt agattatctc actgttttga agatgaagaa atttcaactt 90660 ggtcagagga aagtatatcc tcaaggttag caaagccagg tggcctgggc ccctccagtg 90720 ggatgcagaa cccgggcctt gatcctggtg gacgcagagt ttccaggagg cttttcccac 90780 atgttggggt cccaggctgg aggctggagg agcctgtggt ggtggtggtg gtggtggtgg 90840 tagtggtggt ctgcactaat gttctggtca gcataggggg cgttctcctc ctggagtaaa 90900 aggccagctt agtgagtttt gatgtccctg cccagaagtg gcttcaacac tgtgggtggc 90960 catcctctgg agagtgtttc cccaagtagc tgcctggtcc acccagacct gccacctgga 91020 gtctccatat ggaagagttc aaaatgttct gacaagcacc tcagagcacc tgctttgaga 91080 acactagggg ggagtggcag ctctggcaaa ttaaaatccc catccagcca gccctgcgct 91140 ggcaggtggg ggccctgggc ggccagcacc cggcaaccct ctctgtgtct ggttgcaggg 91200 aacattgagt acagctgccc ggccaccaac gagtgcgaga tcaccaaacg gaggcgcaag 91260 tcctgccagg cctgccgctt catgaaatgc ctcaaagtgg ggatgctgaa ggaaggtaag 91320 agaccccacc gagtcggggt tcactgtgag gctctgcttg ctggggagtt tttgtcccct 91380 gtgagacacc cacaagctgt ggacctgtgt cccagggtga gacccagtct gagcgcccat 91440 ctcctcccac accctgccag cctgccacgg cgcccgcatg gctctcctcc tttagggagg 91500 tgggaattgg aatttcttca ttaaggatcc ttccgaaccc ctgaccccac ttgggcccca 91560 gtgggcctgg cactctggga aggccctcct ttaggggcaa atcccacgtc taccctagga 91620 ggggtaggct taagaggctg ttatatcacc tagcaccctc aagggcttgg gggtgaaaag 91680 gacagacaca ttaagtccgg gaatgataaa taatgttccc ttcacctgtg aagaatggca 91740 tttgttttct ggtgggtgga caggacatgg ctcttgcctt gggaatgctg ctcccttcct 91800 tgttccctct cttcccatcc tctcccttcc ctctcctttc tctccctgcg tcctctgtct 91860 ctagagctgt gctgtctaat atggcaacca ccagccacac gtggctcccg agtgctggtc 91920 caaacagagg tgtgctgagt gtacaacaca tgcctgcttt agaggactta ataggaccat 91980 aaaaggcagt gtaaagtctg gtggtgatcc ttttaaaaat gtgattgcat gcagaaaggc 92040 taatcttctg gacatgttaa ataaaacata ttgtgaaatt agcatcacat gcttctttgt 92100 tttttttttt tttttttgga gacggagtct tgctctgtca cccaggctgg agtgcagtgg 92160 cgcaatctcg gctcactgca agctctgcct cctgggttca cgccattctc atgcctcagc 92220 ctcccgagta gctgggacta caggcgcccg ccacctcgcc cggctaattt ttttgtattt 92280 ttagtagaga cggggtttca cggtgttagc caggatggtc tcgatttcct gacctcgtga 92340 tctgcccgtc tcagcctccc aaagtgctgg gattacaggt gtaagccacc gcacccggcc 92400 tctttttatc tattcgttaa tgtgactact agaaaatttg aaatgacacg tagctctcat 92460 tgggacaact gctccaggtc tcctcttcct cactttctct actgatttgc tccttttttt 92520 atattaaaat attattgata gaggcaaggt cttgccatgt tgctcaggtt ggtctccaac 92580 tcctgggctc aggcagtcct cccacctcag cctcctaaag tgctgggatt acaggcatga 92640 gccactatgc ccagccgatg ttttcagttt gaggaacctt gttcagtacc attttgggga 92700 tgggtcgtga gtgtatgtgt ttccctgctt ctccagcttc caaggggagc cagtgaaaat 92760 tcttagagat caacttttaa gctccgggcc tggaatcctt ctagaagtgg gaggaaacag 92820 gaaaagaggt gtgtgggggt gatcagaagg ggctacagag agaacgaagg gacaggtttg 92880 gaatccagac ccttcctgga gggggaaggc taggagtggg cttctggaag cccagcccag 92940 ccttgggagc cccagggcac tcctgctacc ccctctccca gggccctctg aagataaggg 93000 cccagaccta agacgctttg tcaatacaac ttggaccatc atgtgctata gaaattggac 93060 cttccacttc cgtttaccat ttccaggtcc cccacttcac ctcagctcag cccagcacct 93120 gtatccataa aacagaagct cttgaagcag gccctcggcg gcctttgtgt cgacatggca 93180 cactggcttt taaaatgctc ctcattcggg gcttcattta acccctttgt gatggagtgg 93240 accactcagc tcttagacag gccagctgct tcgttagggg ctcaaccgaa aaaacagtct 93300 cctttccaga ttaaaaatgg gctacatcga gcccgcagaa aggctgtctg ttggttcatt 93360 tttgactcta tataattttg gtcttgctcc tggataggat gacccaaact agtggctgaa 93420 ctgggtcccc tgactcctat gttgggccct ttctgctcct tcagagcctc ctggtattca 93480 cagatgggaa aattgaggca aaaggcccat agaagcatgc ctgagtgctg gtctcttgac 93540 tttctctccg tgtggtgctg ggaatctgag ggtttctaag ctttggagac tcattcattc 93600 ctcttaagcc caagagacag agctgcttga cctgttgttc tcacatacag agctggatgt 93660 gagaacagca ggtcaagcag ggggccaggg gccacttggt cacagcgtgc agcctccctg 93720 cctacttgac agtatccgcg gcacttagag cagccagaag cctcattgtt ttcaatatag 93780 ccctgaattt tacaggtgac aaaatggagc cctacagggg ctggggtgag atgactccta 93840 ccctcagtca cacatcatc tgaggggagc tgggcccaga ggctggaact ttccttgccc 93900 tgttcagtgc ctgctcccca tggcacagca cagggatggg ggaggtcgag agggaacctc 93960 ccactcaatt cctggaccat cttgtaacac tgagcagagt ctctttaggg gctatgcagt 94020 gctgggaaga gagaagggca ctttctagtg gcttcccaga aagcaggaga tggtgaaggg 94080 gtgcactgat ggcagggagg gaggtggtga ggcccacaat tgaccggtgg ccactcagac 94140 atccagactg gcacttgtca gagaaacgag gtggacactg tgtgtcccag gatgatggta 94200 tcgggggtgc tgggaggaca ggggcatgag acccctgctg cctcaagtgg ggaggatgtt 94260 caggggaagc ctcagtgttg acacccctgc cccgctgcaa atatagccct ttggttgatg 94320 gtctttaccc agggtggcag ctggggcctc ccaggcagac atgctcggct cgaaaaggcc 94380 ctttaaggag ttctgcctga aggaggaagg gacagccact agaacgctcc ctccccccact 94440 ccccgccagt gctggcaggt ccagatccaa gagcggggag atgacacaaa ggctcctgag 94500 tacggacaaa gcagggagcc acgtttagtt tctgtcccct gcagggcctt ggagagatcc 94560 tgggatctga agctccgtgg ggaccgaccc ccttgggagg agcatcctcc ttcaacagcc 94620 tgggcccctg ccaggtgggg gctcttggca gctgcctggc ttggcttttg tttgggtgtc 94680 cctcctggct ctgcaggcaa ggcccaggcc ccccaagacc agcgtgggct catcgcccac 94740 ctcagactct gacgggactc taaaaggcaa acttcacctt ccccagggct gctctccgct 94800 ttagggtccc atagtgggcc tctgttgctt ggggggcttt gggggtccag gggcttgggg 94860 agggctgcag acggagagat gtgggtgcct ccgccctctc tgctcccctc gcctgcacgt 94920 ctgaacacca ccctcccgcc ctcatccagc cacattctcc ttgtgtttta tgatttttcc 94980 tttcttaggt aaaataatca gagatcgttt cccagtttgg gggcccagca acagccacag 95040 aagaaatcag acttggggct tcctctggct ctccctctct cttaagactg tggccagctc 95100 agggatctaa gcttttcaga ttcctcacgt ggctggggac agatcctatg gccacgtccc 95160 tgtgactttc tccctggaac atccagagca gaccatggaa aacaggagct gtccaaaggc 95220 ctatcttgct ttaagcaaat ctagtacata aaaatctgta ttttcagaga aaaggtaatt 95280 tttctctttt aaaaactgaa cacaaaatct gggttaggag ttgatggcct gtgttctgcc 95340 cctggttatt aggtattttt gcccgtgtaa tttttttttt ttcttttgag aaagacaaaa 95400 aaaagcctca ctctgtcgcc aggctggagt gcagtggcgc gatctaggct caccacaccc 95460 tccacctccc gggttcaagc aattctcctg cttcagtctc ctgggtagct gagactacaa 95520 gtgtgcaaca ccacgcccag ctaatttttg tatttttagt agagatgggg tttcaccatg 95580 ttggccagga tggtctcagt ctcaaccttg tgatctgccc gcctcagcct cccaaagtgc 95640 tgggattaca ggcgtgagcc actgccccca gctgctgttt aatattatta ctcacgccca 95700 cctgcttcca tttcttcact gtaaaacggg gatgttgata cctgctttcc ttcaccaggt 95760 caaagtgggg acctgggaca gatgggacag ctcctcttgg cagaatccac tatgggattg 95820 ctttgcaatg tcagctccct tgatgcgtta aaatactcca gtgttggatt caggctgggt 95880 gcggtggctc atgcctgtaa tcccagcact tggggaggcc aaggtgggca gatcacctga 95940 ggtcaggagt tcgagaccag cctggccaac atggtaaaat gccttctcta ctaaaaatac 96000 aaaaattagc tgggcgtggt ggcacgcgca tgtaatccca gctactctgg aaactgaggc 96060 aggagcattg cttgaaccca ggaggcagag gttgcagtga gctgagattg tgtcactgca 96120 ttccagcctg ggcgacagtg caagcctctg tctcaaaaaa aaaaaaaaaa aaaaaattct 96180 agtgtttgat tcaaagacaa cctcatttac actcagcttt tcatcagtct gccccttgtg 96240 tttggggagg cagactggtg tctggccacc ctgattttct tcctagattt gttggtggga 96300 atcttaaaag acggccttgt cttgggctgg tccccactgt gggttctaga atcaggatgg 96360 gcagctcccc tggtagtcag cctttgcagc ctggctaggg tgtggactga ctctggaaaa 96420 ccactagctg catttcctaa ggggctcccc gaggcctcag tacagctctg ggatatcagc 96480 aattctctct agacagcctg tccccgccaa cttcacctcc tcctcacctc acctccctca 96540 cgcgaccggc ctcccaagcc cgctccattt ctcccccact cagcccctgc ctgcctttcc 96600 ccaagtgttt tctaaaagat atttgatttc agtgaaagct gggccgacat ccatgcaata 96660 tgctctcact tgctttgtgc ttgttgggaa ggtggagggc tcctccgggg attctgggta 96720 attgtgttag tggccagctc atgtcaggaa attaaaagga ggccctgatc aggttcccac 96780 tgcatgggat ttaatggcct tgtatttata gagtattctg cctctagccc atgccagaaa 96840 tatcactttt tttctggccc tgtgaatgaa gaaagagcaa gagagatgac ttgcctttaa 96900 aaattctttt tcttttccaa aatatattag tgttttgaaa caaaccaact ctttaccact 96960 ttatagaatg gtattgagct acagcctgag aatgccaatg tgtgttgcat ccctttcgag 97020 ccactttaca ttctacacac actgcccccc ccccaacacc accacccccc aaacacgcac 97080 acacacacat acctgacagc tcacaggatc ttcccaggca ccctgaagcc tttgggccac 97140 tcagccacaa tgacctctgg ttggagaagt gttgattgaa tgaagacgaa ggagatgatc 97200 ttgtctgtgc taaatcgttc ttactgttcc ctgcaggctt ttggataacg gtacggtggt 97260 cacgtaggcc tggttaaacc tcatcttcac cacttatcga ctccttgggc cagttactta 97320 aacccctgta agcctccctt tcctcctcca taaaatggga atcataatag tgcctatctt 97380 catcttgctc ccaatcttca gggaaagctc ctagagttat actgtgaagt ctgattgttg 97440 attggagata gatattcttc atgtacaaaa tggatattct tctgtgatcc agaggcaatt 97500 ttgaatctcc tgtagcctca ctccctactc ttgtaatctt gcttcacatt ttcatgaaaa 97560 aatagaaagt caaatgggac acatcttacc ctcctaccat tgaatccaca aacctaccag 97620 tttgtgcacc tgttttctgc cttcttcttg gtagaataga ggtattccca atcctgacaa 97680 acgctggtcc ccctcctgcc cttctgtgct ctgaatcgct ctcttcttta ccaaggactt 97740 cattccttta tttatttttt tttctgagat ggagtctcgc tctgttgccc tggctggact 97800 gcagtggtgc catctctgtt cactgcaacc tctgcctccc aggttcaagc gattctcctg 97860 cctcaacttc ccaagtagct gagattatag gcatgcgcca ccatgcccag ctaagttttt 97920 gtatttttag tagagacagg gtttcaccat gttggtcagg ctgttcgtga actcctgacc 97980 tcaaatgatc tgcccgcctc agcctcccca agtgctggga ttgcaggagt gagctaccat 98040 gcccaacccc ttaccaagga cttcattcct atagtatctt ctctgcttcc agcatcatcg 98100 aattctctct cactactgga tcatttcatt agcacacaag tacacttctg ttctcccatt 98160 atgaagacaa aattaaattt attttttaac ttttaaaaaa tgttaaaaaa attttttttc 98220 acattaaaaa aagagacagg ctggtctcaa actcttgggc tcaagcaatc aacccacctt 98280 agcccctcaa aatgctggga tgacaggggt gggtcaccac gcccagccaa aaacaaaatt 98340 aaatttaaaa aaatccacaa ctatattttg tcccttcatc tccatctaga tattgctacc 98400 tgatcccact gtctttctca acaaaacctc ctaaaggaat tgacagcact tgctatgttc 98460 attttcttgt cccattcacc cctttcttta aaaaaacttc tttaaaaagt aaacattgaa 98520 tagatccaga aatacactta taatatagta cattaggtaa agactaggct gtgttttttg 98580 ttgttttttt ttttttttctt tttttttttt tttttttttg agacagagtc ttgctctgtc 98640 acccaggctg gagtgcaatg gcacaatctt ggctcactgc aacccctgcc tcccaggttc 98700 aagagattct cctgcctcag cctcctgagt agctgctatt acaggcatgc atcaccacgc 98760 ctggttaatt ttttgtaatt ttagtagaga tggggtttca ccatgttggc ccaggctagt 98820 cttgaactcc tgacctcagg tgatccacct gccttggcct cccaaagtgt tgggattata 98880 ggcatgagct actgctccag gccacgctag gcttctaaaa gaaggagact ccctttttcc 98940 ctccacaaac caaaccaaac cccaaaacca cccagaagcc taagcaggat agcagtttca 99000 ttcccgctca tttcttacat aacagtcaga aggtcacagg caatcccaga ctggctggca 99060 gctctgccaa gcttagcatg tggcttgccc ttgtggaccc cagttcttcc catctcacag 99120 acatctagaa ggaggaaaag ctccatgtga agggctggac cctaagtagc acacatctgt 99180 tcttcccact cacagcccag ggccacactt ttctgccagg gagtcttgga attgtagcca 99240 ttatctggga cgctgtgtac ccagctaaaa cgttgttggt atggaaaaag ggaatgacat 99300 attttcaaat acaagtattg tttttttgtg gggattttgt tattgttgct gtttttaaag 99360 agacaaggta ttgctctgtg gcccaggctg gagtgcagtg acatgatcat agctcactgt 99420 aacctcaaac tattgggctc aagagatcct ccccacctca gcctcctaag tagctggtct 99480 acaggcatgt gccaacatgt ggggctaatt taaaaaattt tttttgtaga gacaaaggtc 99540 ttgcttatat tgcccaggct ggtctcgaac ccctggcata aagcaaccct cctgcttcag 99600 cctcccaaat tcttccctag atattttaga cctgaatatc taaccacact attggcattg 99660 ccacttgtgt cctttatgag acatcacaga ttaaacatgt ctagagagga actctaggtt 99720 tgaaccattc ctccttctat tgcttccagt ctttcccatc tcaggaatgg tgatgctagt 99780 cacctattgc tcaaaagaaa cctggaggtc atccttgact cctcccaggt caatgtccaa 99840 aatgtatttc agattctcct acttttcttc atctccatgg tcatgaccct ggtccaagga 99900 agcattgttt tttcctggac cactgtggca gtttcctaac tggacttctg attccactct 99960 tagtcctgtt taatccccct agcagtgatc ttgttaaagc actggtaaga ttctgtcatt 100020 ttgctttaca tcactcagtg gctctccata gcacttaaaa tacaatccaa acactttgct 100080 ttggtcttca agaccttgca tggtctaccc actccctacc tcttcagtat catctcatac 100140 cattcctttc ctgtctgttc actcctaccc actctgctcc agcctccctg gcttattttt 100200 gaccctcaag catgacaaac tgtttcccat cttaggactt tcagggcctt ccctctgcct 100260 ggaatcctct ccccaaagct ggctccttct tatccttccg acctcaagtt aaatgttatc 100320 ttctcagaaa ggcctcccta tccactctat tacttgctgt catatcccct tgtatgcttc 100380 ttcattgaac ttctttcagt ctgacattat cttatttatt tatttatttg cagacgtgtt 100440 tgcactggct gcctctaaca cagttgttct taattcaggc tccaggatgg caagttgcct 100500 ttagttgcac tcagctggag tgcatgattg aaaggcttct taggcagtgt ctgggatcag 100560 caggtaagag tgccatgatt gattagcaat gtctgccaca gactaagaaa tggaaggcag 100620 gggcacaggt gataagtctt tgccatgcct gatctggtca actgagtttc agcgatttga 100680 ccaaggccag acagctagtt aatgacagag ctgggtggaa tctagtctcc ttggctatgt 100740 ggaattcctt ctaagaagcc tattcgaacc tcacggttga tgccttggcc agtagtgaag 100800 cctgtagccc tttctcaaag gggaaaaaag aaaggaacgg aaagggaagc tgggctgaaa 100860 taacttctct gtgtcaggcg tacagttttg gagacttctt ggcagttggg aatgcaggcg 100920 taacacagtt ttgtcaaaat gcccttgggg acatggtggc atggtaagaa gtgtctagag 100980 gagcccagca tgatagcaga cactccttta ataggcagaa ttctgagagc tcatcactca 101040 ctaacactta tccaccacag tgcccggagc ccacagagca gctggcaaaa gccctggaat 101100 attaggtgtc atgtatgtct gtttagctac aaggctctct ctcttagctt ttaggaagtc 101160 aggtgtgagg cactctgcct ttacggtgtg tcactggggt aagaggcagc ccaaatgagc 101220 cattgtgtct gaggcagcaa ggcaagcttg cctgtcaccc agaaacccgc acaggacagg 101280 tggctgaagg aagtccagtg tatacaaggg ttgtggctga gagttcaggg cattgcactg 101340 ggctggaatg cccatcagca tgcccacaca acttccagaa cctcaggggc tcatgatacc 101400 cacatcacct tctgggtggt tttctcctcc tcctggagat gggtcagcta tagtttggta 101460 gaacctacag gcagggagtt cacccccaag tttcctggga agaacactgg ccacataaaa 101520 gtattgaaaa aacgggttta gcacagtgct ccccagacct ggcacataat tagaattagt 101580 agaggagctt tggaaaaata ctcattcctc gacatctccc tagacctact gactcagagc 101640 ctctaaatga gtaagtcctc aaagtctgtg ccgttcaaag gcttcctagg gcattctgag 101700 gttatatggg actggcgtca caagtttagg gcaaagaaga taggacttgg agatctgaaa 101760 atcaaggttc aaaatttccc tgtgacgttt cttggatgtg tgatcctgaa cgagtcgcct 101820 gacctttctg agcttcagat cttgcatgga actaatcata atcatgtata ttcttcctcc 101880 tcaacattgt tgggcagctt aaatgagata cgggtatgaa atagatttgt aaaccatgaa 101940 gctgcttatt tcgttaataa accagggatg ttgaatttgg tgatggggga aagttctgga 102000 taaggggaag agaagggtgt tggtcatgaa aaccttgcaa tgccagtggg gatcttgacc 102060 tcagacctgg atagtagctg atgggagggc agaggccttt ccctcgcctg ccctgtctga 102120 acctttcctg ttggaagaga aatatgatgt gggaagcgcc tgggacaggc ttagggccag 102180 gtgcagggcc acgctttgca gagctttagc cggctatttt tagtgcccgg gtgtaaaaga 102240 aagaagctta aagtggcccc gctgcggctg accctgcaca ctcggctatt tttacttccg 102300 aaagactggg atcttgtcca gcttaggcag ggaagatgag aagaaaggag ggaggtggag 102360 ggaagaagga attattttac ttccattaag aaaaatgtca gaaacctgat cttatcaagt 102420 cagcaagtgg gtatccaatc ccggatgtgt aaggtgccgg ctgtggacgc tgtgacgtgc 102480 ctgcagtgga ttggagaggc cagcagaggg ggagccccgc tcccctcctc tcaaggagtt 102540 tctgtcccag agtggccccg aagcttcttt gctatttttt gtgccctgag ctgggaagtg 102600 ggcttggccc ccacaggcac gaggggcacc agcctggtga cgaggccggt ggaggtggga 102660 gcagttatga ctgcagccaa gggtggaacc tctgttctca agttggacaa aggcagccat 102720 cagacccact ggcatattcc agagagtccc agtgttgggg ctgtgtgccc tgggcacaat 102780 atttaacctc tctgaacctt aatttcttca gggattttgt ttaatacatc tgactgacag 102840 tagttacaac tgtggggatg tgtttctctc ttccatgagg aaggcagttc aagccagact 102900 ctatgacctt caacaggcag atgaaaggca agaagttact actgagtgcc tactgtgtac 102960 caagcactct gttacgtttc aatattttat gttgttaatt ccactaacct gagaaaggat 103020 acatattttt aaaaaatttt aacagcttta ttgaaatata gttcacccat ttaaagtata 103080 cagtttgata gcgttttgta ttcctatatt tgtaaattgt ggcaaaatat acgtcaagta 103140 caacttggca ttttagaaat taagtgtaca attcagtgac atcaaacaca ttcacaatat 103200 tatgcaatca ccggccatgt actgtggctc atgcctgtaa tcccagtatt tcgggaggct 103260 gaagagggtg gattgcttaa gctcaggagt ttgagactag cctggccaac atggtgaaac 103320 cctatctcta caaaatatac aaaaattagc caggtgtggt ggcatgtacc cataatcccg 103380 gctattcagg aggccgaggc aggaggatca cttgagtcca ggatcgtgcc actgcactct 103440 agcctgggtg acaaactgcg accctgtctc aaacaaaaca aaacaaaaca aaacaaaaca 103500 aaacaaacca ttatgtaatc accatcagac caggagttca agtccagcct gggcaacata 103560 gtgagatccc ccatctacca aaaaaaaaaa gaaaggaggg ggccaggcac agtggttcat 103620 acctgtaatc ccagcacttt gggaggctga ggcagaagga tcgcttgagg tcaggagttc 103680 gagaccagcc tgggcaacat agtgagaccc ccatctttgc aaaaaaattt ttaaaaaatt 103740 atctgggtgt catggcatgt gcctatggtc ccagctacgt gggaggctga ggtggaaaga 103800 tctcttgagg ctgggaggtc aaggatgcag agagccagcc tggcctatag agtgagaccc 103860 tgtctcttaa aaaaaaatgg ggtgtggtgg tgtacacttg tagtcccagc tcctggagag 103920 gctgaggcag gaggatcact ggagcccagt agtttgaggt tgcagcgagc tgtgatggac 103980 tcactgcact gcagcctggg caacagagga agaccttgcc tcgaaaaaaa aaaaaaagaa 104040 agaaagaaaa agtggaatca cataatattt gtcctttggt gtccttttgg tttattttcc 104100 ttagcgtagt gtttttaaag tgcattcatg ttatagcata tatcagaact ttattccttt 104160 ctatgactaa gtaacatttc atgtatatac cacatttgct tctccactca tctatccacg 104220 gacacttggg ttgtttccac cttttggcca ttgtgattat gctgcagtga acattgtcct 104280 acaggcgtct gttcaaattc cttcttttta ttttttaaaa atttgcttct tttccccaca 104340 ctacacagat gtatgttcag atttctcttt tcagtttttt tgggggtgta tacctaagag 104400 tgggattgct gaatcatatg gtaattctgt ctagcttttt gaggaaccat caaactatgt 104460 tctacatggt tacaccattt tacttttcca gcagcattgt tttttaagtt tttaattaaa 104520 cttcttattt tgagataatt gcagattcac atgcagttgt aagaaataat acagagagat 104580 gccatgcatc gcttacccag tttcccctaa tggtaacatc ttaaaaaact acagtacaat 104640 atcacaacca ggatattgac attgatacag tcaattgaca ttgatatggt caagatgcag 104700 aaaatcttta agagtgaagt gggttttttt ttttattaat ttttttttta gatggagtct 104760 cactctgttg cccaggctgg agtgaaatgg tgtgatctca actcaagatc tccgtctgca 104820 cagggtcatg tattccaggg attatcaatt tttttctatt catggagcac tcagaaatat 104880 taaaattttg acctgtacac attaagggat taaacggtgt taatggtggt taaaacaaag 104940 gatctgtatt tattgcagta tttggaaata tgtgacactt tacatttgag cattattaat 105000 gcttttttgc attcagaaaa ttatcaataa gatgataaaa tctaataatc ctagacagta 105060 attgtaagtt aattagtatt ttaatgtgtt tcctgagtct acttttagat attttaactaa 105120 tgtaaggaca caaacaataa ggcaactctc atttcaagtt caagtcttct tgtttatttc 105180 cagttagtgt ttgtaagtct taagcatcct aattttaaaa gtaattgccc attgtatcag 105240 tcagtgaaaa ttgctttctg ctgcaagtta cggagaacct gatagctagc agcgtaagca 105300 tggataaatg aagttggttt ttccacctta caagaagcct ggagatgcgc agctgctgta 105360 ttgcacaaag ttctcagcca tggcggcagg ggcgctccag ctctttcttt cttctctggt 105420 gttctttggt gtcctcagac agccatgtca tggctgcaag gtcgttgcca cacctgtagg 105480 cttcaccttc caggctgggg caagagaaag gcaaaagagc tgcactgaac atggctgtcc 105540 cttttctcag aaaagcaaaa ccgttccaga agtcctgcca tggacttaac ctgacatccc 105600 attgccgtgg tggcacgcac ctgtggtccc agctactcga gaggctgagg catgagaatg 105660 gcttgaacct gggaggcgga ggttgcagtg agccgagatc acaccactgc agtccggcct 105720 gggccacaga gtgagagtct gtctcaaaaa cagtaaaaaa aggagaaggc cgcttcactt 105780 tggtggggtt ccatcttccc caaccccagg ctaggggtgc acaggtctgt gtcacaggac 105840 cctcccactc taaatggccc tagcaagtcc tgagtgtgag gcagtgccag agcaggggag 105900 aaatagagca agccagggtc ctgtcctcta agaacccatc gaatcgaaga gctgatgggt 105960 ataaagggaa accagcatga ggtggcctgt gaggtatcag atgaatgttg aagtgctatg 106020 ggttggcagg agggtggtag aagagatggc ctcacccagc ctactggaac tgctttccag 106080 cttaccaagc attttctcat cattaagtca tacaattgtc acaaaagcca tctaccttga 106140 gcagagttgg ttttaccatc gcctccttcc ccagacctga agatgcagct gaagcccact 106200 tgtccaaggc caaataacct gaaataaccc gtaagggaca gagatgggca tgggaccttc 106260 attatcgagc ccatgggctg cagtgattgt gggctgtgct tagggcaggc tcagaagagc 106320 agacaggaag caaggggaac agacacattt cacatcaggt gtcagtttgt gcataattaa 106380 acccaacagg ctactgtttt tttaacagcg taatctgata attgatacac gtattgattg 106440 gagccattga ccactatgct gtaaagatca ggaggagaaa atttagagga gaatttaaca 106500 tttgctgtgc gctgggaggt cataccatgg aatggcaaaa agcttgggtc ttttattggg 106560 gaaatcactg aatctctctg agcctcagtt tttcttattt gtaaaatgag gataatagca 106620 cctgccttat atttttgtgg gttaagtagg gtaatacata cagagagtcc tttacaaatt 106680 atgctgttat cattatcatt attcatgtga tttaccaaaa acttggatgc aatgctgggg 106740 aacagtaata ataaggatga tgataataac cataataatc ccattttcta agcacatgct 106800 gcatcttggg taccatgaca gactttgggg caggactgtg agccgcccct ggccttaacg 106860 ggtgcctagt cagtagggga agcccagtgt gctctgggag cccatgaaga agcccccagc 106920 ctggcatggg gatgaggagg acagaggtac atccacccct gtattcatca agtctttcct 106980 gaacatccat gaaaggtcag gccctatatc aggacacaga acatcccaga tggagacatc 107040 ggcagaggtg gcagctgccc atctccttgc cttgccgagg gacagacacc tctttttatt 107100 ttgtgttgag catgcctcac tctgattgac agctgcttgc cgggaagcag gctggatggg 107160 aagcgagagt tcattccagt ggtatctagg agagaaggtc agtaaagtgg ggaaggggct 107220 tgtcctggac tcaaggagag tatatgttta agatcctggc atatagtagg tgctcagtaa 107280 gtgggggccc ttactgtctc ttatggatga ggtggaccgt tttcactttc ggtcctgtca 107340 ccattccaag gggaagcaga acttggtgga gggtttggtt tggcctgggt atagtgaaca 107400 gaggaggctt ctatgtagac atgtcacagg atagagtcag aaagcttttc tagacaggga 107460 acttttccca aaagactttt acaggaagaa tcatccttcc tgtgtttgtg tctgctcctt 107520 atgctgtcac tgaaggggct tgcagggggt gagggagcaa atgtgagcca aagtgctagc 107580 agcacatagg ttcaggtctg gagctggatg gcatctagct gtccctttag ggtccaaggt 107640 acaggcagaa gttgatggta cagctgcgtt tgctaggatg ccttagtgca gtgctcctca 107700 aactctgttg tccgtgcaaa tcaccttgtc tgattcctct gtggccaggc ctgagatttt 107760 gaggcatcta acaagcctca aatgatggtg atgatgctgg cctgcagacc acacttgagg 107820 aggaagacag cggagactgc tcctgcccac acctactcag cactgtctgt ttgtgtgtgt 107880 gtgtgtgtac gtgtgcatgc gtgcgtgtgt gtgtgtgtgc tgatctgacg cctaggcttt 107940 ctttggccac cagagtctgc tcagcctgga cctgggaggc aggcaagaag cgccaaagca 108000 gccggtagct gggagcctca gttgcccaca gcagtactgt cctcaggaac acatttgtta 108060 ttggctttct tccctccttg gaaactgctc gcatgcacag ccttgtctca gattctgctc 108120 ctggagaagt caacaacaaa tgtcagttac aaaacctgac cttctaggca gaaggggagt 108180 ttattggaag cctatcagga ggttcaaaga gtacatttag aaaccagaca agaaccagga 108240 gaatccctgg agagcccagg agcaggaaac ccagtagcca ggacatactg gccaggggct 108300 gcctacactc tgctggggag gcgctgctgg tctgatcagt cctcaccttc gctctgtcct 108360 tgtgcctccg tttgatggtg cacttggctg agcctgtgtc acgggtccat gccttgacct 108420 ccagagagca gagagaagga gaacatgtac ttctcagata tccattgagg ggtgggacac 108480 agacttccaa cagtttccgt attcccaata ggggaattac attttttaaa ttttcttttg 108540 agatggagtc tcactctgtt actcaggctg gagtgcagtg gtgcaatctc agctcactgc 108600 aacctccacc tcctgggttc aagcgatcct tgtgcctcag ccacccgagt agctggaatt 108660 acaggcacgt gccaccacac ctggctaatt tttgtatttt tggtagagat ggggtttcgc 108720 catggtagct aggctgatct tgaactcctg acctcaaggg ctacggcctc ccaaagtgct 108780 gggattacag gggtgagcca ccgcacctga ccaggggaat tacctttaaa caggaagcct 108840 gggtgggctg ctgagtagac tccccctctc cccgactaaa aaacgtttag caccaggtac 108900 aaatacacca ggttgtgggg ttgaaaaaga cattgctgac aaaaatgagg agttgtgggc 108960 tcactcagtg aactcacagc atccttgccc tccagggctg gagtcctgaa ctgaaaacac 109020 ctggggcagc agaggggtgg ggggtagtgt ccttagcatc ccaaagttcc tttagggcaa 109080 tgtgcactta aaggagtttt ctccactcat tcagtaaaca aagtaatttt gctttcagtt 109140 gctctaggaa acttccttct tctcagggac tgaaatttag tagctgaaca tcctaacaaa 109200 gaaacagcca gaaaatagcc ccaggcatga atgggctcta aatcatcatt ccattaagta 109260 accattgttc tgacttcccc ttgcctgttc tggagaaagg cctgaatccg ggggactggc 109320 agccaacact ctggggctga aggatggaca aggctgggac aggaaggaag attctgtttc 109380 ttctgctccc catctaggaa gtaccagagt ttattagaaa agggaaaggg ccctgaaggt 109440 caactgactg gggctctgtg agggtgatac tcactgcctt tggggaaaag aacagaagtt 109500 gaacctggcc tgtcgcagca gaggctgagg tggcaaccca gctttcttct ctgaggactc 109560 tggtctccgt gtctgacttc ttgtgtgttt cagtcaaggc ccatttcatg atcaggaaaa 109620 gggagctgtt cagtgagctc aaggtaagga ctccaagaag gaacgttgtc tgaggctggc 109680 ctggaagagc cacagcaaga aggcagaagt ggcttccagg ccccacaggg ccccagcacc 109740 atgcttgggg cacctgctct ctggtgcttt ttgtgttggt tcatactttg taaccaattt 109800 gttgggattc atccttgcag gccaggccac atcagtgggt agccagtctg agctgtgtgt 109860 ccacctgagg ccctgtgcct tcgatctgct ggtggggggc atgaaatggt accaatgtgt 109920 ctgtccaggc agcaggagct gtgggtgagg caggcttccg gaaggcaagt tggattcagt 109980 gacaatgaca gatctctcca gggtaaactc tcactcctgg aagtggctgt ctacgtggag 110040 tagccacagc tgcttttgaa cctactttca agatatttcc aggcactgat tttccagtcc 110100 agaggtggcc agcccaactg ttgcattccc atcccctggg gacttgtgta aagacagact 110160 ctagagcttt atgctagaac ctcagagagt ggggtctaga aattgacatt tgtaatgagc 110220 gcctcctcag atgcttcttg tgtgaaaagt ctgaaaaccc ttgaagtgcc tgtgaatgac 110280 cgggattcct ttcttttgtt ggcaagttaa ccctccctgg attcaaagca gatctaacat 110340 aatgtgactt cttccgccaa cacttggtag agtgcctttg ttgacataag gagaaccaag 110400 ggctgagggt tgcttgggat gaatttcaga aggatgctga atccagagag acaggaccag 110460 gcctggggca acgggatgcg ccattactgt tagacaatta ttttaggatt gtccagccac 110520 ctggcctgag gctggccgtg gggcagctgt cgaaggtcat ccgagcaagg ccctgaagga 110580 cccagccagt gctgaaattc caaagtcagt gcttctaccc tggtgatgtt gaacaactgc 110640 tgagatcttt tccctttcct ccccaatagg tgtgcgcctt gatcgagtgc gtggaggccg 110700 tcagaaatac aagcgacggc tggactcaga gagcagccca tacctgagct tacaaatttc 110760 tccacctgct aaaaagccat gtgagtgtca gggcagtccc tgcccctttt gccagcatct 110820 gtacctggaa catcaggcat cccttaggga aacatcatct tcccaccact gggtcatgag 110880 acaatgtgga tcttggggag gtgacatcag tgcctggcac atttagaatg tggctccaaa 110940 tgaagcatgg tcctgacaag ccacgggccc caatgtccag aacatgctcc ccttgccacc 111000 cacccaaagt tgctctgcag gttcctcctg gagaattcgt caggcaactt cccttggagg 111060 gatatttctc aacagcccag atcaccacta ccagcaactt catggagcca gaacaggagg 111120 ggagattata gccgctttga ccttcctgga gctcttagga acccaacttt gcttcctgac 111180 ccatctgagc ctccaccccg gcccctttcc tcttttccca gcatttacct ttccctcttt 111240 ggttgttgca gtgaccaaga ttgtctcata cctactggtg gctgagccgg acaagctcta 111300 tgccatgcct ccccctggta tgcctgaggg ggacatcaag gccctgacca ctctctgtga 111360 cctggcagac cgagagcttg tggtcatcat tggctgggcc aagcacatcc caggtgagca 111420 tgtgggacca ggggagagtg tggccaggga ctctcagccg gtatctccgc agcctaccca 111480 atggctgtgc ttctgatgcc cggatcctgg accccagaag gcctgtgaaa tcctggcagg 111540 cctgtttctc tgagctcctc ttctctcctt gtagcattgg agaggaacag gtagttagaa 111600 gacccagtga ggcttataca ctgctgcagg ctcttcagaa ttagttatca ttcgaggcgg 111660 ggccatgttt ggatctacaa tcagtgtaat attcaaagaa caagttcctt gagcccttaa 111720 agggcaaaga gtagggtttt cttgtagacc ttattggaag gatgccagaa aacaacagaa 111780 gaaagactga ccctctcttc ctattggagg cagcagaatg gagcagtgaa gagcatggcc 111840 ttgggaatca gatcgggatt ccaattctgg gtctgcagct tactagctga gtaaccctag 111900 gtaggccacc tgacctctct gtcaaatggg aatacaagag tcccccactt tgtgagcttt 111960 gatgtgagca tgaaatgaga tcctgtgtgt gaagtgttcg gcacagtgtc tggcatgtgc 112020 tggcatcagt tgcatgccca ctattgccat tcgcctgatc tctaagggag gcctgtctct 112080 ggattggctt ctgagatttt aagggccttt ctggtgcgga aagtgtgtgt tccatgtttc 112140 aggctgtgtg gacttctctt cgctgtgtgt ggacccaaac cctgctttca ccctctctag 112200 gtctgggcag atggcgggag cttttttatt tttgtagaca ccaacaccca tgtattctac 112260 attacataca cattgggggc ctttctctgt gcaatttatt cctcaactcc tttaagactc 112320 taataagttg actcagagtg tggtagaaac atccttttat ccttctggta atgacccacc 112380 atgaacatgg gacaagtcag cttcctgtct gtagatccgt ttttggtttg tcatggctct 112440 gaaaggtgat tacagcagac gatacagcaa aggtgaccta gactttagat accaagccc 112500 acagttgttt gtttgtttgt tttttgagac agagtcttgc tctgttaccc aggctggagt 112560 gtaatggcgc gatctcggct cactgcaacc ttcgcccccc aggttcaagt gattctcggg 112620 cctcagcctc cccagtagct gggattacag gtgcctgcca ccacacccag ctaatttttt 112680 tgtattttta gtagagacgg ggttttgcca tgttggccaa gctggtctcg aactcctgcc 112740 ctcaagtgat ttgcgcacct cagcctccca aagtgctggg attataggca agagccacca 112800 tgtctggccc aaggcccaca gttgattgag agaataaaaa atgtccttcc atgtgagacc 112860 ttacatgccc aagttgcagg aaggagcctt cctgtggaca gggacgcaca gagacatcag 112920 atggcccaga ggctctgctg gcagggactg cctggtggcc cctgggcatt ctgaccaggg 112980 atctgggctg gtacgccctt actaaggagc tcaacctctc ggggattaca cactcagtag 113040 tttttgaatc tgcccagtgc tggttcagca cagatgtggg gtcaggccac tgcttaagac 113100 acttcagcct ggattgctcc actaacccag ggccaaattg ggtacaggta cccctgcccc 113160 cgccccacac tcctgttcca ggttgaacag atcctgcatc ctagcaatgg ctcacgagtg 113220 gcgcctggtg gtcccctggg tcaatgcttc cttcttccac aaccccaccc ctgcaacacc 113280 acggaggaag tagataagac caggagaccc tgtctcccct gcactcattt ttctctgtgc 113340 ctttccacct cccagctcca tctcccatct gtgaccaacc aagagggcat ggctagagca 113400 gagtgagtgc taaaggcata gactttggaa tcaggcagcc tgggctttca tctcagctct 113460 gtccttactg gccttatgca agatactgaa tttttcggag cttcagtgtc cttgtctgta 113520 aaatgggaat cacgatagag ccccttcacg ggattgctgt gaggatgtag cgcgcttagt 113580 gtgtacaccg ggtgaatggc agagacgctt accagcgctg ttgtagttgc taatagtaat 113640 aaaagcctcc tttcatggct tcatttatcc ttgtccaaag ccggattctt tttggtaaaa 113700 aaataaaata aaataaaaac gggctcagtt gtccatctta aatgctaatt tgcctatttt 113760 gcataaatct gcatgctgaa ttctttgcct cctgaccttc cagtgtttaa ggtaaaatta 113820 attagtggag tctcctgcca ctgcatgtaa actcatacta agggcaatga cacaatcaaa 113880 tgcctgattt tttttttttt tttttttttt tgagatggag tctccgctct cttgcctagg 113940 ctggagtgca gtggtgcgat ctcggctcac tgcaatctcc tcccaggttc aagcgattct 114000 cttgcctcag cctcccaagt agctgggact acaggcacgt gccaccaccc ctggctaatt 114060 tttttttcta tctttagtaa agatggggtt tcaccatgtt ggccaggctg gtctcaaact 114120 cctgacctca agggatccac ccacctcagc ctcccaaagt gctgggatta taggcgtgag 114180 ccaccgtgcc tggccaggtg cctgatattt ttaaactaat caacttaatc ccatctcaga 114240 tagatggaa aatgcatctg aagatgggct ccctatccct gagagagaga gagagagaga 114300 gagagagaga gagaaagaaa gagagagaga gagagagctg gttgagtagg gaggataaaa 114360 gctggggccc accctggggc ctgtgttggc tccagtccat ctagttcctg cacagacaga 114420 aagaggggga ctggccactg caggctgctc aggagtagag ctctgaagaa tttaggccag 114480 tgtccttaaa cgcaaggtac cgcatctcac gagagggcat tgcacactta gctttgcatg 114540 cacatattga gaagtcacta cacatgaggt cccctgatag gagttgtggc tgagacaagg 114600 aatttatttt gccccaagga tcccatttgg aacaaggctg acatccaggg ggagcttggt 114660 tcactcagaa tcccagccat tgttcaagtc agtctgacat tgtcctaccc caaatgcagg 114720 ttttttacct tgagttgaat gttccaagta ttgggttccc catagggcaa gcccaagtct 114780 tcagagtgtc catttcttat tccatgagat caagagctag ctgactttaa taggcagtgg 114840 ggaatcactt gatgaattgc agcctcctcc aaatgacccg agcctgccat cctgcctccc 114900 tcggcagcct catgcctgtg ccagccagga aagcctgccc agggagtttc caccaccctg 114960 ccctgcccag gctcccatgt gcagggcatc cccagaggcc tcctcacaaa agtccctcag 115020 cggcactgct cccaggtagc ccccatctga ctcaatgaaa tatgagctgc cgagtgacag 115080 cagctgtgtc tgaagtggcc ccagatccta taattacatc tccctttatt acctctgcta 115140 atggccctcc aggtcgacag aaacgatcat aaattaacag attatgaact ccacttgcca 115200 caaattacgt gctttttttt tttccccctt caattctagg agcttgtggt gccaaatcac 115260 ggatgggggg atggggagct tggggagagc ctgaatgtta tagatgagt tggtgcagat 115320 aaaacaattt tcctggggca gcagagctcc aagtgggagc atgaggagcc agaagctctg 115380 ggcaggcccg agagccttga tgaggcagtg ctgcctgcag tgagcccggc acagggacac 115440 ccctgcactc ccaggggcac ggggcacccc cagaccctcc cggtagcctc ttcaggggcc 115500 tcttggtccc agagttacta ataacttgag aatgagaccc agcccagctg agagaggcag 115560 gggtggaagc gctttactga agggcaggga ggagtgcctg ggctccttct gggttttaaa 115620 taaaagaatc tgtggtttta gtaaagatat cagatgggac agatgggtcg aaattaagag 115680 ttccaaattc cccatcctaa ccttccttct gggaatttcc tgggcagata caaccactgt 115740 gtgaggtgtg tgtgtgggtg ggggttgtgt atgtccccca gtccatgggc ttataccata 115800 acactgcttt acacctgctt tttccattta attatacaaa atagtagcac ttacctggca 115860 aagcagggtt ctaagtgttc cacatgtcag ctcatgtaat ctgaacaacc ccatgaggtg 115920 agtgctgtta tgatttccat tttacagaag aggaaaccga ggcactgaga ggcagacttg 115980 ccagggtcac agctagtgaa cagcagagtt aggaagctga tctctgtgct catacgatta 116040 cacccttttt gcccccttgg ctgtctttcc acgtccacac agagttctaa cttatttggc 116100 acattcattt aactaaaaat tacatctatg taataatcac atgtattaca ttagttacct 116160 tttttttttt ctattttgaa tcatttcaag cagtgatcta ataccctttt acatttatct 116220 ctatgtcttt attcatactt ttctttctag gataaatttc tttttttttc tttttgagcc 116280 aggatctcgc tttgtcaccc aggctggaat gcagtggcat gatcttggct cactggagct 116340 ttgaccacct gggttcaagc gatcctcctg ctgtagcctc ccaagtagca gagatcacag 116400 gcatgcacca ccatgtccgg ctaattttta aattatttgt agagatggtg ttttgccatg 116460 ttgcccaggc tggcattaca ctcctgggct catgtgatcc tcccacctca gcccccaaag 116520 ttctgggatt acaggcgtga gccaccgtgc ctggccacta ggagaaattt ctagcagtag 116580 aattgctagg ttgaagggag catgcctttt attttatttt taatttaatt atatttatga 116640 cttactttta tttttaagca tcttaagcac tgactgggtt cagaagccaa atgtagacac 116700 aaatgtatgt aacagaagtc tcacctctat ccctgtcccc tcccattccg acctcctaaa 116760 agtcaccact ttttctttct caattttcct tctggtgttt ctttttgcaa atactagaaa 116820 agattcagat gttaaaagat gtcaaatatc tccccctccc ttccttgcac aaaatgaaga 116880 aggctgtatc accaattcag cgccttggag tatacctttg gattatcaaa gctattttca 116940 gggctttttg aaaatgttca gggaggaaga gagtgatcag gggctgagtc cagaactcga 117000 agcagcctat cagaggtttg ggaacaggcc tcccgggtac atcctcccat ggcagcacaa 117060 aactttccaa gtccagtctc cctcccacca cccaagggca gggcctgact cctacaagat 117120 aggcaaaggc agctaaccct gaacctgagt ccaaagatct tagagggtct aaccaagtac 117180 tgtgggcaca ttttcttgtc tcctgggagt caaagcctgt ggcatttgtc cattctctct 117240 ctccttttag ctgcaaagtt ttgtcgggca gcttctttgc tgtgcccagt cgtgggggtg 117300 gggaaggaac agctcagtgt ctgtgcaccc tgggaactca gagctgggat gggccatcca 117360 ggggcacctg ggcatgtgcc tcatcaaagg tgccctcacc accctgcttg acagctcagc 117420 cctcaaggct ccccttccac aaagcctccc cagactcttg tttggcccac cttccccagt 117480 gcgtgctctc agggccctgc atttgctgta gctcttctta tattgcaact ttgtgctgac 117540 ttgtgcccct tggtgtgtgt cttccccttc actgtaaacc gttgaaggca gggagcagtt 117600 ctggactgag cacaccattc tgtccccggt gcctagcaca ggcctggcac ttagtaggtg 117660 ctctgtaagt ttttgctgaa tgtctcaaag ggcagaaaag cattctagta acatcctaat 117720 gattgtacct gcaggattca ctgcacaggg gacttttccc ctgcgtttcc agaagcctag 117780 tccttacctc atcctctctc tccaccacct tccaattcag ttgtctgcta atttcacccc 117840 tgccctcctc ctccatctcc cctccagtct gtctgctttt agaccccctc cctagagctg 117900 tccaacactc cccccaacac actctccggt gctggctgat tggtatctgt taattaatgt 117960 tgcccaaggc ctctctccta ctcaaagacc tgataaggga aattggatgt ccatttctat 118020 ctatctttta ttacctccca gctcccccgg ccaccacagg cagccacaca ccctctccca 118080 tgcagggaat ctggacaacc acacacacac acacacacac acacacacac acaccctgat 118140 cccctgtcac agcctctccc ctgagaaggt gcatcaatca aagctccccc gtgtcagtcg 118200 gtgtaatcac tcctgctctt ttgttgatca cccatggatt ccattagcca gtggtgatct 118260 gaggcccaag ttgtatagat cagtcttggg aactgtgata attcacttgg agaatgctca 118320 cagggtaagg gtggtctgcc tggtcaggga ccttcagctc caggagtgac ccctaaggtt 118380 caactgccat gccctgtgtg gaagccaggg aagaagtggc atttggagac aggacagcag 118440 atggatgggg gagaccacac aagccaaaga gctgggtggt ccagaagctc aggaccaccc 118500 aggcctccag gcaagtccag agaggagaag tgagtgatgc caatggtgtg ccaacaacaa 118560 caacaatatt tagtaacaac agccacagcc atgaccagca ccctagcatg ttgagtgctg 118620 atggcgccgg gagaggtgcc cagcactgta catgcatctt ctcttttcgc ccccacagca 118680 ccccacatca gaaagtggct tccagccaag gatggggtct aagtcagcaa atgaagtaga 118740 aagtccttcc taggcaaaat tacccctgaa aaaaatccct tcatgtcagt tacccatagt 118800 gcatggtgca aacaactttg tggatgccct tccttctttg aataaatcca gcatgtccgt 118860 gttagaacca atcactgagt ttctgtttga atctccagtg aagttactgc cttgtgtttg 118920 gtggttaaga tgcttgaaaa tcagctgact tatttattta cttactctct cttactctcc 118980 tataaatcaa gatgttaatt gactttgcct aatttaagtg catgtataat gcaattccag 119040 tacattatca ttgttctgca gtgagaactt tcatctcatc attagtaata atagctcagt 119100 aaatactttg tatattctgg aatcatcgtc tcatttagac ctcacagcaa ctctctgaag 119160 tagaccctac tattatacta tttcctagat gaggaagcta aggtttggag aagttgcatg 119220 gttttcacaa gttcagccta cagctagtaa gcgggagtca gggttcaacc caggcaatcc 119280 ccacagttca ctgggcaaga cagtgtcaca gttctggagc cttctccatg cccaacttta 119340 ttttcactgt ggaatcagcc tcctcaaata gcagggaggg gggaactagc atgattccaa 119400 gctcccggaa caggcctgct gggtcatcgt taagcagaga gttatggccc gggaagaggg 119460 gctccgaccc tggggagagca ggctgtcctg tgagaaagtg cccctgaccc cgggggctct 119520 tgatctctta gcagccccag gctatggtca ctggggcctt cccctgtggc tttgaacagc 119580 tgcgtcctcg ttcttggtca ggcccgtggg tctctgcaca gctgagactg catcaaggat 119640 caggtgtcat tttcaaatac caaagcctcc cctggtttga gcagagagtg ggccctggaa 119700 actccccaga gtggccgaga gcacgtactg ctgcctcctg gttccagtat gtactcagtc 119760 actcctttaa ctacaaatgc attgaattaa acaaaaagcc tctacagacg tttggaaaat 119820 accatagagc taacaatcat aatgataaca acaactgtca acatgactg agctctcatt 119880 ttgtaagtct tttccgtgaa ttccaagtct gaggcattcc ccaaggggag gacagtgagt 119940 cttacgctac acagggaaag cctgggggca ggatccaggg gtgccaggga caccccgcaa 120000 ccagccacgc cctgcaacct ctgcccccag cgagccccag ggaggcccct ggtccgccct 120060 cctgacctgc tgctgccctc tgtgccccct cttcctgcag gcttctcaag cctctccctg 120120 ggggaccaga tgagcctgct gcagagtgcc tggatggaaa tcctcatcct gggcatcgtg 120180 taccgctcgc tgccctatga cgacaagctg gtgtacgctg aggactacat catggatgag 120240 gagcactccc gcctcgcggg gctgctggag ctctaccggg ccatcctgca gctggtacgc 120300 aggtacaaga agctcaaggt ggagaaggag gagtttgtga cgctcaaggc cctggccctc 120360 gccaactccg gtaagggcgg cggcggggcc tggaagggga gcttctaggg ctctgcatgg 120420 gcctaatgag cccatccctg gggcctgtgg gcagggctgg ctgccatgga tagagatgaa 120480 aggaaaacac tgaaactttt tattactgaa gattgtccaa ggggtggcct gcagataaaa 120540 agctggtgat gaaggctgac actggctgag catttcctaa gcctcagaca tccagactgg 120600 cacactggct aaggacatgg gttctgaggc cacatgcta aggagcaaat cccacgtcta 120660 ccaactgggc aagttgcttc actctgtgcc tcagtttctt catcagtaaa aggagggcag 120720 ccaaacagtc cctactctac aaggctattg acaggatttc tttatacata attatattgc 120780 ttgcaacatg cttggcacat aaaaagcact caattattta tttatttgtt tattatagac 120840 ggggtcttgt tctgtcgccc aggtaggagt gctgtggctt gatcctagct cactgcagtc 120900 tcaaactttt gggctcaagc catcctccca cctcagcctc ctgagtagct ggaactacag 120960 gcatgtgcca ttattccggc caattcttat ttctattttt tatggagata gggtctcact 121020 atgttgccca ggttggtccc aaactcctgg gctcaagcaa tcctctcacc tcagcctccc 121080 aaagtgttgg cactacaggt atgagccacc acgctcagcg tcaacttatt aaattagcta 121140 ggagtttatt gaattcttac aaacaaccca agagtaaaat tcttattgtt gcaaccccat 121200 tttacagatg tggaaactga gacctgaaaa agtaaagaaa atcacccagg gtcacacagt 121260 taaaaagtgt cagagttaag agtcaaacca aggtcctctg attccaaaat caacctgaac 121320 ctatacccac tccttgaatc tttcagtcaa atttcttgaa cacaggagga taaaaccttc 121380 ccaactgagt ggtttaagct ggagttacaa aggaggactc actccatttc attagcatcc 121440 accaacttct ggctagatta tctgaggaga gaggcaggcg ttgggtaatg ccagtaagtg 121500 aacttgaatg taaccaacat ccacacttag agagcttcca cactattcag ggaatggtgc 121560 tgggtgccag ggggctgcag gagaaggata aatacagggt accctcccta aagagaacac 121620 atgccaggaa tcacacacat aattctgttg cagagcagtg tgtggcagag ttaactgccc 121680 aggtctgggt cagatagacc caagttcaaa ttctatctct gacacttcct agcagtatga 121740 ccttgggtaa ctcagtgtcc ttgtgtgttc agtggggata ttctgagcac ctcttccaag 121800 cactttattt tattttattt ttttttgaga cagagtctca ctctgtggcc tgggctggcg 121860 tgcagcgatg caatctcggc tcactgcaac ctctgcctcc cgggttcaag cgattctcgt 121920 gtctcagcct tccgagtagc tgggactaca tgcgtgcacc gccacactca gctaattttt 121980 gtatttttag tagagacggg gtttcgctat gttgcccagg ctggtctcaa actcctggcc 122040 tcaagtgatc cacccgcctt ggcatcccaa agtgagggga ttacaggtgt gagccaccac 122100 gcccagcccc aagtgctttt gtgagtatta aagattgact gacaataaag cactcagcct 122160 ggtgcctggc ctagaggaaa tgttcaataa atattaatta ttatcattac tattaatgat 122220 agaggataca aagtgttatt agcatatgga aaagggagaa ctggctccca gatgcagaca 122280 gtacacacag ggtaaccaac tggtttgctc aatactgtcc tgcttttact gaaagtccca 122340 tatcccagga aactcgtcag tccctggcaa actgggacag ttggttgccc tagcacatgg 122400 cttcatggtg catgcagggg gtgctgttga tgacccactt ggatcccttt tactgggtta 122460 gtgcatccat cccctagctg ctaacagttc agaggtaccc ctttgcaggg cctaccctcc 122520 tctgccttgc ccagagggtt atgtggccct ttccttggca ccaccaggca atggtggacc 122580 cacatgggta caaaagttcg gatcagagcc ctgcatggga tcaggctgaa gccgaggtcc 122640 catctttgcc ttgctttctc cttccctgtg cttcctgcct ccccacttcc tttctcctga 122700 acacatgccc cccgtaaatg tctgtaccta aacccttgcc tcaggctctg ctcccaggga 122760 acctgatcta acacagaaaa ggatgccact tttttagttc aaatctttta ttaacaataa 122820 atgaatgcaa aataatatta aaaattttac atacgtccac agagaatatt tacacattga 122880 attccaaaat tgtagtgcat tctttgttag agaatcctaa tgctgttttt ttaaagtata 122940 gttttagatt tacagaataa cttttttttt tttttttgag acagaatttt gctcttgttg 123000 cccaggctgg aatgcagtgg tgcaatctcg gcccactgca acctccgcct cctgggttca 123060 agcgattctc ttgcctcagc ctccttagta gctgggatta caggcgcctg ccaccacgcc 123120 cggctaattt ttgtattttt agtagagaca tggtttcacc atgttggcca ggctggtctc 123180 aaactcccga cctcaggtga tccacccacc tcagcctctc acagtgctgg gattgcgggc 123240 gtgagtcact gcacccggcc gactgtgttg tattgttcta taggttttga caaatgcata 123300 atgacatgtt tctacaatga cgtatcatac aaaatagcat caaggccctg tgcttcacct 123360 acacagaggg gagcatttga accaggcatt gcagagggct tcgaggttct gtcaggtgga 123420 ggaggagcaa aagcagttaa agcagaggaa gccaggtgca caaagccagg tgcaggaagg 123480 ctggccaggc cttggaggtc aagccctcta ttctgggctc tcctaactta caccagacac 123540 agagctcaat cttgcctgtg ttgggagagg agagtaaaga ggtagtgtct cctccactct 123600 tacttggtcc tcagtaccgg accacaccac accagctttc agctgctctt cccttgatct 123660 cacatggacc cgcacacata cacacatgca catgtataca tacaaacaca tgcacataca 123720 tacacaccca cacatacaca cacatgtgaa cacacatatg tgcatgcaca tacccacata 123780 tgcagccaca tccatgtgta tatagacata cacacacacc cccacctgag gacccgtgga 123840 ggtttgtcaa tatgaatcca tatcgaactt ctgttggcat caacagaact tctgttgaca 123900 tcagactttg cctgagtgca ctttgtcgca tggtatgagg tttcaggtct ccggacttct 123960 tgccccagca acagttagag agccatcctg cagttggtgc acaggataag aagctggagg 124020 tggaggagga gtttgtgatg ttcagggcct tggctgaccc ccaagaggga acacacgttg 124080 cttattccag agagccgcag tccttgatga ggggaatgct tccttcccag cacggagggg 124140 ttgagcatga ggccctcttg ctatcaagta gatgctcaga aagcaggctg gctagtcttt 124200 tttttttttt ttttttaagt aatggttttc cagcctaggc aacagagtga gaccctttct 124260 cagaaataaa taaataaata aaataaagta atgatttaaa ggagtgcttg ccaaagtacc 124320 tgtgatgaag gacccatttt taaatgtttc aaaatgttca atccattacg gacagatcat 124380 tttgtaaaat acaacaaaaa taaattatta aaaaaatgaa attaaaaacc agatgtacaa 124440 aacatgagcc aaatttttaa atttttatat ataacagaca taaatataaa tcatccttcc 124500 aaagtgctat aaagtttcta aatgcttact ctcagtttct tatcacagac cagtaacctc 124560 cagagggcag gcaggaacca gtctgtgtac catgctttga gcaggctggg tttaaagcgt 124620 gtacttcagg gtcagtgaga cctgggttca aatcctgcct ctgccacctg ctggctgagt 124680 gtctggcaac ctgacctttg tgagtctcag tttcctcatc tgtgaaatag ggagaacagc 124740 agctcattgt gaagaatgtg cagtgacgca cataaggctg tggccaccgt gcttggcaca 124800 gatccctcct agctcattgt gtttctgttg ggctctgtgg ggtatagtgg gtggcctggg 124860 gaagaggagc cagttggatg tagctcctgc ttccaaggga gataagacat gagcctggat 124920 gtggcagaaa gagccagtga ttcctgacat gagagaggat catgtaaagg gctcaaggag 124980 ggaagagtaa attgttttca gctggggagg tagactctga gtggggtctt aaagcaagag 125040 acggttcggt aggatgggaa gagggagtgt aaacttctgt agtggggcca tcagctccag 125100 gcaggaaatg gggaaagaac aggccagttt cagggagagg ctagaaaagc aggctggggt 125160 cagaccagaa gctcaagggc tgtgaaggga ttggattgtg atggggtcag tacagggagg 125220 caggaagggt tgtgcgggag tgacctgcct cagccttgag ggagaaagat cacccaggca 125280 tcatagagaa aatgtgttgg ctggaggagg gatgggtgcc aggagaccat tgaggtgtcc 125340 tagcagcagc cctcagggcg accatgggtg ccactgctga ggctcagtgc acgggatgac 125400 tcaggtgtgg ctccagtggc tcaggggggct gacgctgggc agaagtgccc aagcacatca 125460 gaggcagact gtgaccccac accatggccc cctgggagcc tgctggctgc ggtttacccc 125520 acatcccagc catccccaaa gctccctgac agcaggaaaa attcatagcc attgattttg 125580 taattaacag tttatcaatg ccatcgatac agaccggctg atggattgca aagaaattaa 125640 tcttgcaatg ttattttatt tcatttttgg tcgaaggcag ctgccaattt tgtcctcctt 125700 ggggagagtc gggggaggat ggagagggcg gggagaggga gctggcagga gtcaggagcc 125760 cacatggcaa tgcccagcca tgttaggtac acactctgta agtggccgag agtgtaggat 125820 tagggccttg cttcatctcc cacctgatga cgaaggagtg ctcactgcct tggtagcagg 125880 gagcagaaaa atgtggagga ggcttgggtg tggggccagt gaagactcag ccctgcaagg 125940 acactcaccc ccagcctgag tccccacagg aataacacta cctgacattg accaggtgct 126000 gatcacgctc tgggtaatgt gctgcttcag tcaccctcac caccaccctg tgagtcctca 126060 ctcctgtgtt ttacagccgg cttagaccca gctgtaacgt ggccgtcagc aggtgcctcc 126120 ctgccgtgct gggatgtagg taaattttgt ttgaacccct aggtcatggc ctaagttcaa 126180 aacctttccc aagattttag agaactccct atagctccct ccatcaccgt gcctcatgcc 126240 gccaccttga cacagtgctc agcccctata tctgtgcctg tattctgtgt cctataacca 126300 gaattttgtc aggttagcga ttgcactgaa gacttgggga gctggtgcct ggcagcggca 126360 gctgcagtgg ttgtcatggt gatagtagtg atggggctag gggcggtggt aggggtgata 126420 ccgctaccag ggcactgact tgtgacaagt tctgttataa acccttgacc tgtttaactc 126480 ctttaagccc ttgaggtagg catggctatt atcccatttt acaagtgagg aaaatgaggc 126540 tcagagaagt taataacttg cccaaaatca cacagcctgc aagtaaggga cacaggattc 126600 caagtctggc tccagggtct ctgctgccac cccctggtga cctcttgaga aatgtcccct 126660 gtagacgcca gtctctccct gggtttgagt cccagctctg tcattagctt ctgtgacctc 126720 tctgggcctc agattggctc tctgtgaaga gagggttctg aagatacccc tgcctgcctc 126780 catgctgcct cctggacccc aagatggccc ccacaccagg cagcactccc tggccaagcc 126840 tgctaatgct cgtccttgtg cctgcagatt ccatgtacat cgaggatcta gaggctgtcc 126900 agaagctgca ggacctgctg cacgaggcac tgcaggacta cgagctgagc cagcgccatg 126960 aggagccctg gaggacgggc aagctgctgc tgacactgcc gctgctgcgg cagacggccg 127020 ccaaggccgt gcagcacttc tatagcgtca aactgcaggg caaagtgccc atgcacaaac 127080 tcttcctgga gatgctggag gccaaggtgt gatggccccg cacacggacc aatgcccacc 127140 tacagacaga caaacggaca gaccgaggtg gagacctcca cagccaccag cctccacctt 127200 caacccctgt atcatggctc tgagctgtcc cagaggcggg ggtttctcac ctcctggctg 127260 tgtgcagact cccgggtgca gtggggtggg ggacggggat gggggggcag gggtgtgggg 127320 ctcgactgta actggctttt tctttggtat gtctttcctt ctccatggac ggtgcggagg 127380 cctgggccag ggctgactcc cttcaggagt ggaggccact ggagcaagtg ccctctcccc 127440 tccaccgagc caccaagagg cagcatgtgc atttcctaac tcccttgccc cctcccccat 127500 ctgtggcctg ggtgggcact gctcaggctg gataccacct ggaggttttc cttccgcaga 127560 gggcaggtac gcaagggaca acagtatctt tcttccagag gtcctacctg ctctgagatc 127620 ctctggggcc ggtcaagagg ccccatacct tccacagttt ccactcagct ttcagccagg 127680 gggtacccac aggagagcag cggctagagc tcaagtgctt cctgggcacc ccacccctcg 127740 gggcctaccc ccctgcctgt cacccaccgc gccggtgtcc acctgtcctc ctcctcttct 127800 cctccccccg ggagtccccc gctacttcct gaccctacct cagagctcac tcacccagtg 127860 ggttcagcca gccacagcga ctccaggggc tgtagacagg aacgcgctgg cacagagaag 127920 agcggggacc acaccatcct cccaagaacc ctctccctct tcctgccttc cccctctccc 127980 tgaagggcag gtccaggcca agtgagcctg tgagaagctc aggagcctgg ctccatccaa 128040 gagcaccccg gggggaggat caggacagga tggacagagg cccagactca tctttgccaa 128100 gcacagaaag gccgagcagc tgagataagt aggcagggga gccccaaagg gagggaactc 128160 agcggggtgg cctgcctcat ccttcctggc ttcccttccc tgcactcagc atcatgccac 128220 agggctagtg taccagtgcc acaggagggg tgccctccta ccacacttgg gctaccagag 128280 gtttggtgta gctcccctgg gcaccgcgag cacgccagct ctctggcagg acccctgcag 128340 tccccctggc tgtgccaggt aaccaaccgt cttggtttgt ccaggacgtt tctttatccc 128400 aggaaactcc tctaccccag gcacacgggg acagtgggtc actctatttc tgtggatggc 128460 cgtgaaagtt ttcactaact caaggggcag ccctgaacac ccatttgtgc tcacaggttg 128520 gccaagagca gcttagagga tctcccaagg atgaaagaat gtcaagccat gatggaaaat 128580 gccccttcca atcagctgcc ttcacaagca gggatcagag caactccccg gggatcccca 128640 atccacgccc ttctagtcca acccccctca atgagagagg caggcagatc tcacccagca 128700 ctaggacacc aggaggccag gtaactttct gcagcttttc catagaagcc ctggtcccac 128760 ctccttggct ctaccccagg aacctcccgg cctgggcttc tgggctggga cgtgctgagg 128820 tcatcccaga caggagggag ggctggctga aatccacaaa ctgcagagca gctctctgat 128880 ggtgtcccac acagaaaatg ttaaggattt caagagccct cccagaccag tgatgtgtcc 128940 ctccggctcc ccttgcctgt ggggaatcgg gtctgagtca cttgatgagt aggcactgga 129000 gccgttaccc aggatgctgc ggccctagcc ctccatgcag cccatcttcc ctcatttggg 129060 tggaggcaca catttggggc aaaggcccct tcttggcatc aaggaacacc agctacaaac 129120 caagtctagc acagtgttta gaggctctgc cctgaggttc tgctccggag aaaccttcac 129180 agtagagacc ttggggtgtg tgctttggga ctccctcagt ctctcactgt gctgtgtcct 129240 tgcagcgggg ccgaggtagc accctgctct gtcacttcct gctcaagctg gaggacccag 129300 gcggcagggc atcatgccca gctggcatct gctgtctgtc ttttctaggg aaagcatctc 129360 tggctcacca tgtaacatct ggcttggagc aagtgggtgt tctgcacacc aggcagctgc 129420 acctcactgg atctagtgtt gctgcgagtg acctcacttc agagcccctc tagcagagtg 129480 gggcggaagt cctgatggtt ggtgtccatg aggtggaagc tgcttttata cttaaaactc 129540 agatcacaac aggaaatgtg tcagtaacaa tggaactcca tccaatggga aagttcctgg 129600 tactgaaggg gtccattgga cactcagaaa agaagttcag gggccaactt cttagctgga 129660 atcctggcca gatgaggacc ctctccgggg aagggagagg actgacttag tggaaggtgg 129720 tgaagtgagg agagtttagg ggaaccttcc cccagtggaa cagatctcaa gtttacccta 129780 aacctgccat ttctggaaaa tctgtaaaga ggaaacagcc tgtctcagct gtactctcat 129840 gatacaggtc atttgaaatg aaccaagaaa taaaacatga aaatccaacc atggagaagg 129900 tggtatggct gggttttgtt tggtcccctt gtccttatac gttctaaagt ttccagactg 129960 gctttgtcac tttgtgaact cgtcatgtgt gaaaaccaat ctttgcatat agggaacttc 130020 ctcgggccac actttaagaa ccaagtaaga ggctctcaag actccagcag agtcgggagg 130080 ccatggcagc gccttagagg agctggaacc tgcacccacc tgtgtcggtg gggggggcct 130140 cctttcccca tagactctgc cctccctctg tgcagatgga agtggcaggg gagggtgacc 130200 agcttgtgac aagaagactg aagggtccag agtccatgct cacggaacag caccaaagaa 130260 aagcactatg tggaaagatt gttttatttt ctaataatga taatatggct ggaatggctt 130320 cttaagatgt atatattttt taaaatggca gttccccatt gcagcatcac ctacttgtat 130380 gtctttctgc ctctgtatat gttctcccag aaacccccat gtaaatcaaa tgccctagga 130440 tgcttccatc ctggtcccat gtatctggaa tctaataaat aaggaaagga a 130491

Claims (15)

An estrogen related receptor beta (ESRRB ) gene variant comprising the nucleotide sequence of SEQ ID NO: 1,
The genetic variant further comprises a nucleotide sequence in which guanine (G), which is the first base of the intron region sequence immediately after base 787 in the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A). The gene variant according to claim 1, wherein the ESRRB gene variant comprises a nucleotide sequence in which guanine (G), which is the 111,414th base in the nucleotide sequence of SEQ ID NO: 2, is substituted with adenine (A). Poly which includes the nucleotide sequence of SEQ ID NO: 1 and further comprises a nucleotide sequence in which guanine (G), which is the first base of the intron region sequence immediately after base 787 in the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A) A composition for diagnosing the onset or risk of developing hereditary hearing loss, comprising an agent capable of specifically detecting nucleotides. delete The composition of claim 3, wherein the agent capable of specifically detecting the polynucleotide is a primer, a probe, or an antisense nucleic acid. The composition of claim 5, wherein the antisense nucleic acid is the polynucleotide or a fragment thereof, or complementary thereto. 7. The composition of claim 6, wherein the fragment has at least 10 nucleotides. A kit for diagnosing the onset or risk of developing hereditary hearing loss comprising the composition of any one of claims 3 and 5 to 7. delete The kit according to claim 8, wherein the kit is an RT-PCR kit or a microarray chip kit. In order to provide information for diagnosing hereditary hearing loss or predicting the risk of developing it, in a biological sample isolated from an individual,
Poly which includes the nucleotide sequence of SEQ ID NO: 1 and further comprises a nucleotide sequence in which guanine (G), which is the first base of the intron region sequence immediately after base 787 in the nucleotide sequence of SEQ ID NO: 1, is substituted with adenine (A) A method for detecting nucleotides. delete The method of claim 11 , wherein the method is to detect the polynucleotide using an agent capable of specifically detecting the polynucleotide. The method according to claim 13, wherein the agent capable of specifically detecting the polynucleotide is a primer, a probe, or an antisense nucleic acid. The method according to claim 11, wherein the method for detecting the polynucleotide is selected from the group consisting of reverse transcription polymerase reaction, competitive reverse transcription polymerase reaction, real-time reverse transcription polymerase reaction, RNase protection assay (RPA), Northern blotting and DNA chip. How to use .

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