KR102274721B1 - Mutation gene for diagnosing ovarian cancers and diagnostic method using the same - Google Patents

Abstract

The present invention relates to nine mutant genes for the diagnosis of ovarian cancer and a method for predicting or diagnosing the onset of ovarian cancer using the same.

Description

Mutant gene for ovarian cancer diagnosis and diagnostic method using the same {MUTATION GENE FOR DIAGNOSING OVARIAN CANCERS AND DIAGNOSTIC METHOD USING THE SAME}

The present invention relates to a mutant gene for diagnosing ovarian cancer and a method for predicting or diagnosing the onset of ovarian cancer using the same.

Ovarian cancer is a cancer that occurs in the ovary, and is largely divided into epithelial cell carcinoma, germ cell tumor, and gonad stromal tumor depending on the tissue in which the cancer occurs. account for more than 90% of the

Currently, the diagnosis method of ovarian cancer mainly uses a method that measures the concentration of cancer antigen 125 (CA125) in the blood or a screening method using transvaginal ultrasound (TVUS). However, CA125 is also frequently increased under endometrial and pelvic inflammatory conditions, resulting in poor accuracy, and the TVUS method can help in finding a tumor, but has a disadvantage in that it cannot distinguish between benign and malignant. In addition, a tissue biopsy is performed to confirm the diagnosis of a patient suspected of ovarian cancer and to test for a genetic mutation, but there are disadvantages in that it causes pain in the patient and it is difficult to show tumor heterogeneity. Accordingly, research to accurately diagnose ovarian cancer through liquid biopsy using blood from ovarian cancer patients is being actively conducted.

Korean Patent No. 04684666

Accordingly, the present inventors identified mutations specific to ovarian cancer by profiling gene mutations using NGS from cfDNA and CTCs isolated from biomaterials of individuals, and predicting or diagnosing the onset of ovarian cancer using this gene mutation. The present invention was completed by finding that it could be done.

In order to achieve the above object, the present invention provides a polynucleotide as a diagnostic marker for ovarian cancer, comprising at least one selected from the group consisting of polynucleotides containing the following gene mutations:

a polynucleotide comprising a BAP1 mutation, consisting of a polynucleotide sequence in which base T at position 548 is substituted with C in the polynucleotide consisting of the sequence of SEQ ID NO: 1;

a polynucleotide comprising a CDK4 mutation consisting of a polynucleotide sequence in which C is inserted between bases 753 and 754 in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 2;

a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1966th base T is substituted with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;

a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1147th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;

a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which the 1900th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;

a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which base G at 1672 is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;

a polynucleotide comprising a TP53 mutation consisting of a polynucleotide sequence in which the 31st base G is replaced with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 5;

a polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 3785 is replaced with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6; and

A polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 37943 is replaced with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6.

The present invention also provides a composition for diagnosing ovarian cancer comprising a primer or probe that specifically binds to the polynucleotide according to the present invention.

The present invention also provides a mutant protein encoded from the polynucleotide according to the present invention.

In addition, the present invention provides a composition for diagnosing ovarian cancer, comprising the agent capable of detecting the expression of the mutant protein according to the present invention.

In addition, the present invention is a method comprising the steps of isolating a nucleic acid molecule from a biological sample of a subject; detecting the expression of at least one mutant gene selected from the group consisting of BAP1, CDK4, ERBB2, FGFR3, PTCH1 and TP53 or a mutant protein encoded by the mutant gene from the nucleic acid molecule; And when the mutant gene or mutant protein is detected, there is a possibility of developing ovarian cancer, comprising the step of determining that ovarian cancer has been invented, predicting the possibility of developing ovarian cancer or providing a method of providing information necessary for diagnosing the onset do.

The BAP1, CDK4, ERBB2, FGFR3, PTCH1 and TP53 mutant genes according to the present invention are mutations found only in ovarian cancer, and are cell-free circulating DNA (cfDNA) isolated from blood and circulating tumor cells. ; CTCs) can be easily detected, enabling rapid diagnosis of ovarian cancer and minimizing patient discomfort.

1 is a schematic diagram showing a method for detecting a mutant gene according to an embodiment of the present invention.
2 shows the frequency of alleles of (A) 20 cfDNA samples and (B) 20 ctcDNA samples according to an embodiment of the present invention.
3 shows the results of profiling a single nucleotide sequence variation in gynecological cancer according to an embodiment of the present invention.
Figure 4 shows the position of ovarian cancer-specific single nucleotide sequence mutation according to an embodiment of the present invention.
Figure 5 shows the complementary profiling results of cfDNA and ctcDNA according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description, detailed descriptions of well-known techniques known to those skilled in the art may be omitted. In addition, in describing the present invention, when it is determined that a detailed description of a related known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description may be omitted. In addition, the terms used in this specification are terms used to properly express the preferred embodiment of the present invention, which may vary according to the intention of a user or operator, or customs in the field to which the present invention belongs.

Therefore, definitions of these terms should be made based on the content throughout this specification. Throughout the specification, when a part "includes" a certain component, it means that other components may be further included, rather than excluding other components, unless otherwise stated.

Terms used to express a mutation in the specification of the present invention are defined as follows. In the definition of a mutation, the indicated number means the position where the mutation started on the nucleotide sequence of the gene, and the number of the mutation not marked with the IVS letter means the position on the mRNA nucleotide sequence except for the intron nucleotide sequence. The present invention is applied to the nucleotide sequence of all normal genes. Insertion mutations are denoted by “ins” and deletion mutations are denoted by “del”. The letters after "ins" and "del" refer to the actual inserted or deleted nucleotides. The symbol ">" is used to indicate mutations in which nucleotides have been substituted, where the letter before ">" is the nucleotide of the normal gene, and the letter after ">" is the nucleotide of the mutant gene. And, the X after ">" means that the nucleotide before ">" is substituted with another nucleotide to generate a stop codon, and the amino acid encoded by the nucleotide sequence after the number is deleted. “fs” means “frameshift”, which means that a frameshift occurs from the position of the nucleotide sequence described before “fs”.

The present invention relates to a polynucleotide as a diagnostic marker for ovarian cancer, comprising at least one selected from the group consisting of polynucleotides comprising the following genetic mutations:

a polynucleotide comprising a BAP1 mutation, consisting of a polynucleotide sequence in which base T at position 548 is substituted with C in the polynucleotide consisting of the sequence of SEQ ID NO: 1;

a polynucleotide comprising a CDK4 mutation consisting of a polynucleotide sequence in which C is inserted between bases 753 and 754 in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 2;

a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1966th base T is substituted with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;

a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1147th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;

a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which the 1900th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;

a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which base G at 1672 is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;

a polynucleotide comprising a TP53 mutation consisting of a polynucleotide sequence in which the 31st base G is replaced with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 5;

a polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 3785 is replaced with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6; and

A polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 37943 is replaced with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6.

Among the nine gene mutations, the TP53 mutation is a mutation registered with COSMIC, and the remaining eight mutations are novel mutations.

The polynucleotide may be a nucleic acid molecule isolated from a biological sample of an individual, for example, a cell-free circulating DNA (cfDNA) and/or a circulating tumor cell DNA (ctcDNA) detected from. . For example, as shown in FIG. 1 , after separating circulating tumor cells (CTC) and plasma from whole blood and extracting cell-free DNA and circulating tumor cell DNA from them, respectively, next-generation sequencing (NGS) may be used to identify a gene mutation, but is not limited thereto.

The present invention also provides a composition for diagnosing ovarian cancer comprising a primer or probe that specifically binds to the polynucleotide according to the present invention.

The polynucleotide includes BAP1, CDK4, ERBB2, FGFR3, PTCH1 and TP53 gene mutations, the nucleotide sequence of the polynucleotide is known, and the mutation site used as a diagnostic marker is defined by the present invention. Based on this , primers or probes that specifically bind to BAP1, CDK4, ERBB2, FGFR3, PTCH1 and TP53 gene mutations can be easily designed.

In addition, the present invention provides a composition for diagnosing ovarian cancer comprising a mutant protein encoded from the polynucleotide according to the present invention and an agent capable of detecting the expression of the mutant protein.

The mutant protein may be one or more mutant proteins selected from the group consisting of the following mutant proteins:

BAP1 mutant protein in which L, which is the 183th amino acid residue in the amino acid sequence of SEQ ID NO: 7, is substituted with P;

CDK4 mutant protein in which the 252th amino acid residue R in the amino acid sequence of SEQ ID NO: 8 is frameshifted;

ERBB2 mutant protein in which S, which is the 656th amino acid residue in the amino acid sequence of SEQ ID NO: 9, is substituted with P;

ERBB2 mutant protein in which G, which is the 383th amino acid residue in the amino acid sequence of SEQ ID NO: 9, is substituted with R;

FGFR3 mutant protein in which A, which is the 634th amino acid residue in the amino acid sequence of SEQ ID NO: 10, is substituted with T;

FGFR3 mutant protein in which A, which is the 558th amino acid residue in the amino acid sequence of SEQ ID NO: 10, is substituted with T;

TP53 mutant protein in which E, which is the 11th amino acid residue in the amino acid sequence of SEQ ID NO: 11, is substituted with Q;

PTCH1 mutant protein in which P, which is the 1262th amino acid residue in the amino acid sequence of SEQ ID NO: 12, is substituted with L; and

PTCH1 mutant protein in which P, which is the 1315th amino acid residue in the amino acid sequence of SEQ ID NO: 12, is substituted with S.

The mutant protein itself can be used as a diagnostic marker for the diagnosis of ovarian cancer, or an agent capable of detecting the expression of the mutant protein, for example, an antibody, an aptamer, etc. can be used to diagnose ovarian cancer. can, but is not limited thereto.

In addition, the present invention provides a method for predicting the likelihood of developing ovarian cancer or providing information necessary for diagnosing the onset of ovarian cancer.

The method may include, but is not limited to, the following steps:

isolating the nucleic acid molecule from the subject's biological sample;

detecting the expression of at least one mutant gene selected from the group consisting of BAP1, CDK4, ERBB2, FGFR3, PTCH1 and TP53 or a mutant protein encoded by the mutant gene from the nucleic acid molecule; and

If the mutant gene or mutant protein is detected, there is a possibility of developing ovarian cancer or determining that ovarian cancer has been invented.

The subject may be a mammal including a human, preferably a human, but may not be limited thereto.

The ovarian cancer may include ovarian cancer, cervical cancer, uterine cancer, uterine body cancer, vulvar cancer, and the like, and may be, for example, ovarian cancer.

The biological sample may be used without limitation as long as it is a sample in the form of a liquid capable of performing a liquid biopsy, and specifically may be blood, tears, urine, saliva or sweat, for example, blood.

The nucleic acid molecule may be cell-free circulating DNA (cfDNA), circulating tumor cell DNA (ctcDNA), or a combination thereof, but is not limited thereto. The cell-free DNA and circulating tumor cell DNA may be isolated from blood, but is not limited thereto.

The BAP1, CDK4, ERBB2, FGFR3, PTCH1 and TP53 mutant genes may comprise one or more polynucleotides selected from the following:

a polynucleotide comprising a BAP1 mutation, consisting of a polynucleotide sequence in which base T at position 548 is substituted with C in the polynucleotide consisting of the sequence of SEQ ID NO: 1;

a polynucleotide comprising a CDK4 mutation consisting of a polynucleotide sequence in which C is inserted between bases 753 and 754 in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 2;

a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1966th base T is substituted with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;

a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1147th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;

a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which the 1900th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;

a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which base G at 1672 is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;

a polynucleotide comprising a TP53 mutation consisting of a polynucleotide sequence in which the 31st base G is replaced with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 5;

a polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 3785 is replaced with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6; and

A polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 37943 is replaced with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6.

Methods for detecting the mutant gene include next-generation sequencing (NGS), reverse transcription polymerase reaction, competitive reverse transcription polymerase reaction, real-time reverse transcription polymerase reaction, RNase protection assay (RPA), Northern blotting, DNA chip, etc. It may be, for example, next-generation sequencing (NGS). The process of detecting a mutant gene using next-generation sequencing is shown in FIG. 1 . Specifically, after isolating circulating tumor cells (CTC) and plasma from whole blood and extracting cell-free DNA and circulating tumor cell DNA from them, respectively, gene mutations can be detected using next-generation sequencing.

In addition, the method for detecting the mutant gene may be detection using a primer or a probe that specifically binds to the mutant gene, but is not limited thereto.

The mutant protein may comprise one or more mutant proteins selected from:

BAP1 mutant protein in which L, which is the 183th amino acid residue in the amino acid sequence of SEQ ID NO: 7, is substituted with P;

CDK4 mutant protein in which the 252th amino acid residue R in the amino acid sequence of SEQ ID NO: 8 is frameshifted;

ERBB2 mutant protein in which S, which is the 656th amino acid residue in the amino acid sequence of SEQ ID NO: 9, is substituted with P;

ERBB2 mutant protein in which G, which is the 383th amino acid residue in the amino acid sequence of SEQ ID NO: 9, is substituted with R;

FGFR3 mutant protein in which A, which is the 634th amino acid residue in the amino acid sequence of SEQ ID NO: 10, is substituted with T;

a FGFR3 mutant protein in which A, which is the 558th amino acid residue in the amino acid sequence of SEQ ID NO: 10, is substituted with T ; a TP53 mutant protein in which E, which is the 11th amino acid residue, is substituted with Q in the amino acid sequence of SEQ ID NO: 11;

PTCH1 mutant protein in which P, which is the 1262th amino acid residue in the amino acid sequence of SEQ ID NO: 12, is substituted with L; and

PTCH1 mutant protein in which P, which is the 1315th amino acid residue in the amino acid sequence of SEQ ID NO: 12, is substituted with S.

The method for detecting the mutant protein may be detected using an antibody or aptamer specific for the mutant protein, but may not be limited thereto.

Hereinafter, the present invention will be described in more detail by way of Examples. These examples are merely for illustrating the present invention in more detail, and it will be apparent to those skilled in the art that the scope of the present invention is not limited to these examples.

[Example]

Example 1: Detection and Analysis of Mutant Genes

clinical sample

Samples of cfDNA and CTCs from 20 patients diagnosed with gynecological cancer were target-sequenced using our custom cancer panel. All patients consented to participate in the experiment, and all samples were collected according to the IRBs of Chungbuk National University Hospital. Detailed clinicopathological information for 20 cases is presented in Table 1 and Table S1. A total of 7 ml of peripheral blood was collected from each patient into EDTA tubes. 2 ml of blood was treated with CTC enhancer and 5 ml of blood was used for plasma preparation.

Sample preparation

Plasma was isolated from 5 ml of whole blood using density gradient centrifugation in a Ficoll-Paque™ PLUS (GE Healthcare). cfDNA was extracted from the isolated plasma sample using the QIAamp Circulating Nucleic Acid Kit (Qiagen). cfDNA was extracted from 2 ml to 4 ml of plasma and quantified with a Qubit 3.0 fluorometer (Invitrogen). The amount of cfDNA was measured with a 2100 Bioanalyzer (Agilent) to confirm that it was not contaminated with genomic DNA.

2 ml of whole blood was treated to increase CTCs using the CD-PRIMETM system (Clinomics Inc.). After centrifugation of whole blood using the same volume of Ficoll-Paque™ PLUS solution, a peripheral blood mononuclear cell (PBMC) fraction was recovered from the separated blood cell fraction and applied to the CD-PRIMETM platform. was made to CTCs were abundant in the membrane of CD-CTC-disc, and after placing the membrane in a collection tube, DNA was extracted using QIAamp DNA Micro Kit (Qiagen). Whole genome amplification was performed on DNA extracted from CTCs using the REPLI-g Mini Kit (Qiagen).

Library Preparation and Sequencing

A total of 10 ng of cfDNA or CTC-derived DNA (ctcDNA) was used for library construction. Library preparation was performed using Ion Ampliseq Library Kit 2.0 (Thermo Fisher Scientific). For sample multiplexing, the Ion Express Barcode Adapters Kit (Thermo Fisher Scientific) was used, and the library was purified using Agencourt AMPure XP reagent (Beckman Coulter). Libraries were quantified using a Qubit 3.0 fluorometer and 2100 Bioanalyzer. Templates for the library were prepared using an Ion Chef Instrument (Thermo Fisher Scientific) accompanied by an Ion 540 Chef Kit (Thermo Fisher Scientific). Multiplex templates were sequenced with an Ion S5 XL system (Thermo Fisher Scientific).

Sequencing Data Analysis

The human genome sequence hg19 was used as a reference. Sequence and data analysis was performed using Torrent Suite software (5.8.0). For sequencing coverage analysis, coverage Analysis (5.8.0.1) plugins were used and the VCF file was created using te variantCaller (5.8.0.19) plugins. Annotations of variants were obtained using Ion Reporter (5.10.2.0) software. To filter out potential sequence background noise, Common Korean SNVs included in the KoVariome whole genome sequence (WGS) database from 50 healthy, unrelated Korean individuals were excluded. SIFT, PolyPhen-2 and OncoKDM used were used to determine the possible impact of the variants to predict the effect of genetic variants on protein function. In addition, variants were annotated using ClinVar, COSMIC, and TCGA to match them to previously reported variants. To provide additional clinical outcomes of annotated tumor variants, OncoKB, a precision oncology knowledge base that provides guiding information for FDA-approved treatments in clinical trials, was used.

result

Patient characterization

The diversity of genomic variants found was characterized by sequencing cfDNA and ctcDNA from 20 gynecological cancer patients. Cancer was divided into 5 distinct types. The most frequent type was ovarian cancer (n=9, 45%), followed by cervical cancer (n=4, 20%), uterine cancer (n=3, 15%), and cervical cancer (n=3, 15%). ) and vulvar cancer (n=1, 5%). Eight patients were stage 1 (40%), 4 patients were stage 2 (20%), 5 patients were stage 3 (25%) and 3 patients were stage 4 (15%). The mean age of the patients was 62 years (42-91 years) (Table 1).

Mutation profiling of cfDNA and ctcDNA using a cancer panel

cfDNA and CTCs were isolated from the blood of gynecological cancer patients, and 51 candidate genes with known drug or therapeutic relevance were NGS sequenced using a custom cancer panel (Table 2). The average sequencing coverage obtained using the cancer panel of the present invention was higher than 1000X, which is sequencing data covering about 136.75 kb. A cancer panel was used to identify 23 genetic variants from 51 candidate genes. Table 2 shows the total variants detected from the patient's cfDNA and ctcDNA. A total of 63 variants were found in 23 candidate genes. In silico analysis predicted the impact of genetic variants on protein function, and as expected, 44% of the total variants (28 out of 63) were potentially pathogenic mutations.

Mutation frequency in cfDNA and ctcDNA of gynecological cancer

A total of 63 gene variants were detected in 23 genes, and all patients had at least one variant in cfDNA or ctcDNA. The average number of mutated genes per patient was 4.8 (range 1-11). The most frequently substituted genes in cfDNA samples were ESR1 (50%, 10 out of 20 cfDNA samples), TSC2 (40%), BRCA2 (25%), TP53 (30%), BRCA1 (25%), FGFR3 ( 25%) and PTCH1 (25%). In contrast, the most frequently substituted genes in ctcDNA samples were TSC2 (30%, 6 out of 20 ctcDNA samples), BRCA1 (25%), ERBB2 (25%) and TP53 (25%). The distribution of gene mutations in all patients is shown in Figures 2A and 2B.

In addition, the mutation spectrum of gynecological cancer patients was comprehensively analyzed (FIG. 3). of ERBB2 Cases 1147G>A and 1966T>C were found in circulating tumor cells of ovarian cancer patients, 1642C>T in uterine cancer, and 1959_1960 mutations in circulating tumor cells of endometrial cancer patients. In the case of BAP1, 548T>C was found in circulating tumor cells of ovarian cancer patients, and 1168C>A was found in circulating tumor cells of endometrial cancer patients. CDK4 753_754insC was found in ovarian cancer circulating tumor cells, FGFR3 1900G>A was found in ovarian cancer circulating tumor cells, and 1672G>A was found in ovarian cancer cell-free DNA. 3785C >T and 3943C>T in PTCH1 were found in cell-free DNA of ovarian cancer patients. TP53 31G>C was found in circulating tumor cells of ovarian cancer patients, and 214C>G was found in cervical, uterine, and endometrial cancer patients as well as ovarian cancer.

Six single sequence mutations (SNVs) were detected in circulating tumor cells of 55% of ovarian cancer patients: BAP1 548T>C, CDK4 753_754insC, ERBB2 1966T>C, ERBB2 1147G>A, FGFR3 1900G>A, and TP53 31G>C. FGFR3 1672G>A, PTCH1 3785C>T and PTCH1 3943C>T were detected in circulating tumor cells and cell-free DNA of ovarian cancer patients. These mutations were not found in other carcinomas (Fig. 3). The mutation position of the ovarian cancer-specific single nucleotide sequence is as shown in FIG. 4 .

Complementary genomic profiling of cfDNA and CTCs

To analyze the clonal heterogeneity of cfDNA and ctcDNA, sequence data from cfDNA and ctcDNA were compared. 5A shows that only 10 out of a total of 63 variants detected are shared by cfDNA and ctcDNA. Most variants were found only in cfDNA or ctcDNA. These results suggest that an approach using both will give more accuracy in diagnosing and monitoring tumor progression.

Independent mutation analysis revealed 31 variants in the 31 variant cfDNA sample and 22 variants in the ctcDNA sample (Supplementary Fig. S1B). As a result of this analysis, it was confirmed that only 15.8% of the variants detected in cfDNA or ctcDNA overlapped (10 out of 63 variants).

Although profiling of cfDNA and CTCs liquid biopsies is a convenient assay for gene mutations, low concentrations of cfDNA and CTCs in the blood limit detection limits. Our data analyzed cfDNA and ctcDNA to find mutations in 95% (19 of 20 patients) and 75% (15 of 20 patients) of patients, respectively. However, simultaneous analysis of both cfDNA and ctcDNA increased by 100% (Fig. 5B). Although cfDNA can be used to detect genetic variants in 95% of patients, simultaneous analysis of cfDNA and ctcDNA can provide more diverse genetic information for treating cancer.

Identification of Effect of Variation on Protein Structure

Table 4 shows the effect of ovarian cancer-specific six single nucleotide sequence mutations on protein structure using an in silico analysis tool. Five of the six single nucleotide sequence mutations are domain portions of the protein, and TP53 E11Q is reported by COSMIC.

So far, with respect to the present invention, the preferred embodiments have been looked at. Those of ordinary skill in the art to which the present invention pertains will understand that the present invention can be implemented in a modified form without departing from the essential characteristics of the present invention. Therefore, the disclosed embodiments are to be considered in an illustrative rather than a restrictive sense. The scope of the present invention is indicated in the claims rather than the foregoing description, and all differences within the scope equivalent thereto should be construed as being included in the present invention.

<110> INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY <120> MUTATION GENE FOR DIAGNOSING OVARIAN CANCERS AND DIAGNOSTIC METHOD USING THE SAME <130> PI <160> 12 <170> KoPatentIn 3.0 <210> 1 <211> 9302 <212> DNA <213> Homo sapiens <400> 1 gcccctcccc ttcgcccccg tcccgtcccg ccccgcccct ccccttcgcc cccgtccctc 60 cccttcgccc ccgtccctcc gcgcgtgcgc gttcgccttc gagcgcatgc ccgcatctgc 120 tgtccgacag gcggaagacg agcccagagg cggagcaggg ccgtcgcgcc ttggtgacgt 180 ctgccgccgg cgcgggcggg tgacgcgact gggcccgttg tctgtgtgtg ggactgaggg 240 gccccggggg cggtgggggc tcccggtggg ggcagcggtg gggagggagg gcctggacat 300 ggcgctgagg ggccgccccg cgggaagatg aataagggct ggctggagct ggagagcgac 360 ccaggtgagg aggggaccgg gagggccagg ggctggggag gccggatggg ccggggacgc 420 gcctgcctga ccatcacccc ctcctcttgt cgccccaccc aggcctcttc accctgctcg 480 tggaagattt cggtaagagc cttttctccc tgccggaccg gggctgtggc ggcccacccc 540 tgcgccctca ctcatcaggg gctgtccttc cctactgctt tcctttcctc atcgcaggtg 600 tcaagggggt gcaagtggag gagatctacg accttcagag caaatgtcag gggtgagtgg 660 ctgtacacca gggctgcccc ttacacccag agtgctgggg aaggtcccag agaacagggc 720 cccttaggga agacagtgcc aggaacccta cgttgtaaaa tctcacagaa agcagcagcc 780 ttgctctctg agtgcccgct cctgatcaaa ctgatacttt cttttctccc aaactttcct 840 tagcgcttcc ctttttgtag cagccccctc cccaccccta agcatccttt ggttcagctg 900 ctttcctggc cttgcagcgg gaagaccccg gtcacacaat gtcttttgtg cagttgtgta 960 atgtattaat tttagtgtgc ccatgtgtcc ttggctttaa tcctgacaca aagtcatcct 1020 gtattgattg gttggggtga caaggcccct cctgggtgcc cacacttaga gtcttttccc 1080 agtggtcctg cagaatagat gtgtaagaga gtagcaacag tagcaaccgt gactgaacca 1140 agaagtctac tttaatttcc tggaacaaaa gagactggtg tgggtgttca tttgctttcc 1200 tgactgcatt ggggcccaca agtgagaagg agtgcctcag ttcctcatca gagtttttgt 1260 tcttgtctta ctttgtgttc ctaccctgtc ccatccttgg ccctcagttc cagcttttct 1320 tctcttaccc agaactatag acttcataag gagactgggt ggactcctgg agcatcacag 1380 tcagaggctt atgctttgct ctgcctgtgg caggcctttg gtgtgtgagg gcacaaggcc 1440 acttcagaca cagtgttggg aagaagccag gggagagggg ggatcacagc aaggacacct 1500 gagtgatgac gcagtgcaaa ggattaatgg gagaaagaag ggaatgctga ttgtcttctc 1560 ccctttggct gatctggctc tgccccttac ttcccccagc cctgtatatg gatttatctt 1620 cctgttcaaa tggatcgaag agcgccggtc ccggcgaaag gtctctacct tggtggatga 1680 tacgtccgtg attgatgatg atattgtgaa taacatgttc tttgcccacc aggtctgctg 1740 gactctgtgc tttgtttgga gggtgggatg ctgccatgtt tttgcttggg aagtggaaat 1800 ggaggaagac aggaggagga gataggcaga ttctaggggt ggtagctaca gaaatcctct 1860 ggcagaacga actgaactct taattcatta aagggaacag ctttagagta ggagggtgtc 1920 tgagtccact ctctgtgtcc tcagatatcc agtgggtatt tggtaggtgc ttgttaaatg 1980 aataaacatt aggcaaagat gaaaggagct gagaagggga gttgtccaga tatgactgac 2040 ctgctctgga tccccattct tgatgtatat gggcttgggg cttgcagtga ggggtgctgt 2100 gtatgggtga ctattcttgg tttcacagct gatacccaac tcttgtgcaa ctcatgcctt 2160 gctgagcgtg ctcctgaact gcagcagcgt ggacctggga cccaccctga gtcgcatgaa 2220 ggacttcacc aagggtttca gccctgaggt aggctgcagt gccttcatcc tggctcacag 2280 ccaactgggc agatctgacc ctgagggcca ctgggaatgc taccacatga tattgggtac 2340 tattaggctg tttctttttc aaatgattgt ttatgttaca tttgactctt aaataaattg 2400 tgtaaggcca ttgtttttag atgcagttgc ggggaaagga cacaggccta gggagggagg 2460 agagtttcct taagtcagac catgtcagaa ccttctctgt caggactttt cctctcaggc 2520 catgttgctt cctagtgtcc actaattacc atgcaaggcc agcacagtcc atctctttgg 2580 ggctccagag ctcttttctg cccccaccag ccttttaaga aagttcgtct gtgttccttc 2640 cgattcctgg aatgcctcca ggctgctctc tgaagctttg ccttccaccc atagtcctac 2700 ctgaggagaa attattctga tacggcctta ttttcttccc cgtagagcaa aggatatgcg 2760 attggcaatg ccccggagtt ggccaaggcc cataatagcc atgccaggtg tgtgggagct 2820 gtgggagctg atgtggggtg ggagtagggg gagtatcatt ttttgggccc tgactctgtt 2880 tttccccagg cccgagccac gccacctccc tgagaagcag aatggcctta gtgcagtgcg 2940 gaccatggag gcgttccact ttgtcagcta tgtgcctatc acaggccggc tctttgagct 3000 ggatgggctg aaggtctacc ccattgacca tggtaggcac catgagctgg aggcctgttg 3060 ggtgtctctg cctacctcct agggagctgg ggctcagggc cctctggtat gtggtaccca 3120 gtggcagggg ttgtcggtac cgacacccgg ctctggctgg ggtttcaccc tacaccatat 3180 tgcccgacca gctcctgatt ccctggctca actgctcttc tctgtcttcc ttcccactcc 3240 tggcctgccc aaactcaggg tttccttctc gctgattcct tgtcttggtc tccactaggg 3300 ccctgggggg aggacgagga gtggacagac aaggcccggc gggtcatcat ggagcgtatc 3360 ggcctcgcca ctgcagggta agggccctgt gcctgccctg ttctactctc tggagctgta 3420 cctactttgg gagggacaga gagtatccag gtgatttgta aattgcaagg ccatatggtg 3480 aatctggcaa gatcaggctt agatcatggg ttctcaactt gttgtcttat ttcctgcctg 3540 ggctgcctgt ggcctgctcc tgggtgggct gggggagggg caggcctcag tggagcctta 3600 ggcagcccag gtctgctggt tcacttccag ataggcccct catacagctt gttggaaggt 3660 accagctcag gtgcctggca tgtatggcta gtcgctgcct gcctgttggg gtggggccta 3720 tacctacagc tgcaggtgtg actgcaggga gccctgccag gatatctgcc tcaacctgat 3780 ggcggggccg gggcgggagc tgctctcacg gctgcggctg tgactgcagg gagccctacc 3840 acgacatccg cttcaacctg atggcagtgg tgcccgaccg caggatcaag tatgaggcca 3900 ggctgcatgt gctgaaggtg aaccgtcaga cagtactaga ggctctgcag caggtaggtg 3960 ccctttcttc ctggcctctg cccagcccaa ccctccctgc attcctcctc ccttccccca 4020 cagcatttgt ctctgattcg tgaacatact ctcttgtaga tctgggcttc agctaaccac 4080 atcttttctt tgcccccatt gtgggaaagg tgggacttgg agtggggagg gagaatagct 4140 tctaaaagga agtttgggtt tgggtgtttt atttccctgt gagtgaatgg gtagagccaa 4200 ggccattatt cctttaggtc ctcagccctt agctatttaa ggtagaagcc cgggtctacc 4260 ctttctcctc tgagccctgg attctgttgt tagctgataa gagtaacaca gccagagctg 4320 attcagaccc acaagtctca agagtcacag ctgcctgagg agtccaagtc agccagcaac 4380 aagtccccgc tggtgctgga agcaaacagg gcccctgcag cctctgaggg caaccacaca 4440 ggtactgggg ggtttgggac ctcttgtgga cctcagagcc acccgctaat gtctgacatg 4500 ggaggcctaa acagggaaag tctttttctg gggatgtcct tgggcagtgt tcttcccccg 4560 tcagaaggta gagggagagc agtccttccc taaagaaagg cacctgtaaa gggccgctgt 4620 taccacaggc ccctgggccc ttctctgtaa tgtacactcc ctttcttgtt ttctctagag 4680 gcggtttttt ttttttttttt tttttttttt tttcttcctg cttctttttt cccatctcat 4740 tctttgccct gtctcattgc gggatcatga cttagagctt gctgactccc attgcaccag 4800 ctggctgggc tgttcttctc tgggaagtgc tggttcacag ggccggggag actgtgagct 4860 tttcttggag atcctactgg aggtcctgcc tgtgttcttg ccctgtctca gatggtgcag 4920 aggaggcggc tggttcatgc gcacaagccc catcccacag ccctcccaac aaacccaagc 4980 tagtggtgaa gcctccaggc agcagcctca atggggttca ccccaacccc actcccattg 5040 tccagcggct gccggccttt ctagacaatc acaattatgc caagtccccc atgcaggtaa 5100 gctgggagca cccttgcagg attctctact tgattctctt gagaggctgc aacaggcaat 5160 tttcccatgt ggttccttgg tgttcatcct tggcatggct gggtcaagct gcctgggcct 5220 gggttgctag gttcctctgc ctgatatgaa aaggccccca caacagcagg agcttaggga 5280 ggcagggaga gctcctttga atttaatcta gttacgtggc tgtgggatta aatgtttagg 5340 tcacgctcct tggtacaact tcatgggttg ggttttactg gcaaaataaa ggcatgtgtt 5400 tcagggcact ctgtttctct taaaacccct ccgtggggtt ctatccagtg taagtgggtg 5460 gcagcctccc cacaagccaa ggacaggcca tggaacagct ggaggggttc cgctgactca 5520 gtctggaaaa ccatgttggc tttctctctg gctgtgagtg tctaggctca gcctgggccg 5580 agcagcactt gtttgtaact gccctggtct ttgtcccagg aggaagaaga cctggcggca 5640 ggtgtgggcc gcagccgagt tccagtccgc ccaccccagc agtactcaga tgatgaggat 5700 gactatgagg atgacgagga ggatgacgtg cagaacacca actctgccct taggtcagcc 5760 cagctttcta aggctaccag gttctaggtg cttcggatcc catcctgaat atctcagtct 5820 gtgtctgaga atgccctgca gcagataatg ttgagcacct gcggagtttg gggccctggg 5880 ggaggctggc atgatggggc tgaccccagg tccccaggaa gtttttggtg ggctgggggg 5940 taaggctgag cacgtaagct tatatcatgt cctattggaa gtggcctttt agccaggcct 6000 tgaaggattg gttggggcag ggatggagga gatgtgggtg gtggggaggc agctttgctg 6060 gaacacaggg cattggcaaa aggccaggag tgggatggct ggaatagagg aagtgtcttt 6120 tgaggacact tggctgcagc tgtcagaact tgatgccagg cttagcatgg ctagttcaag 6180 ttgcttggac caagtataag gagttttagg gtcagcccct ggaggtcggg atgtatttaa 6240 gccattctgg gtactgctgg gtatggtcac ctggcccgtt cccttgcttc acatcttctc 6300 gggccccaca ggtataaggg gaagggaaca gggaagccag gggcattgag cggttctgct 6360 gatgggcaac tgtcagtgct gcagcccaac accatcaacg tcttggctga gaagctcaaa 6420 gagtcccaga aggacctctc aattcctctg tccatcaaga ctagcagcgg ggctgggagt 6480 ccggctgtgg cagtgcccac acactcgcag ccctcaccca cccccagcaa tgagagtaca 6540 gacacggcct ctgagatcgg cagtgctttc aactcgccac tgcgctcgcc tatccgctca 6600 gccaacccga cgcggccctc cagccctgtc acctcccaca tctccaaggt gctttttgga 6660 gaggatgaca gcctgctgcg tgttgactgc atacgctaca accgtgctgt ccgtgatctg 6720 ggtcctgtca tcagcacagg cctgctgcac ctggctgagg atggggtgct gagtcccctg 6780 gcgctgacag gtgggccttg gactggctca ctggccactt ggtgcaccca ggagggagga 6840 gggaagtggc caagtgacca caaagtgtcc tgcactctga tgattttctt gtgacctctc 6900 ttcccagagg gtgggaaggg ttcctcgccc tccatcagac caatccaagg cagccagggg 6960 tccagcagcc cagtggagaa ggaggtcgtg gaagccacgg acagcagaga gaagacgggg 7020 atggtgaggc ctggcgagcc cttgagtggg gagaaatact cacccaaggt gagcctccgt 7080 tgtggttttc tcctttaatc ctggcagagg gtaaggcctg agctcctcct gcccaggtgc 7140 caagttcttg attggaactt tggtgtgaag attggtggct ggagccatgt gccagaagac 7200 tttctgggtt gggtggtggc aggggccttg ataggcatgg actcgctgct catccttgcc 7260 tctagctgcc tattgctcgt ggggctttgt tgctggcccg ccccgatcag aggtgcaatg 7320 ctgggttttg gcaggagctg ctggcactgc tgaagtgtgt ggaggctgag attgcaaact 7380 atgaggcgtg cctcaaggag gaggtagaga agaggaagaa gttcaaggtg ggtgatttct 7440 ccagttgcct gatctggcct ctcccgaggt ccactggtgg ctgctctggc aagattggct 7500 ccagtgctct cagtcttctt ctctcctaca gattgatgac cagagaagga cccacaacta 7560 cgatgagttc atctgcacct ttatctccat gctggctcag gaaggtgagg ggatgcgctg 7620 ctgtcttaac tggaatgccc tgctgagggc cgtgtccttc agctcccctc ccctggcctc 7680 tcctgaggct tgagcagacc ttggggcaca gggagggcca tgagagcctc agctcctggc 7740 ctgaggcagc cagcacctgc tcaagggtct ctacctcttc gcaggcatgc tggccaacct 7800 agtggagcag aacatctccg tgcggcggcg ccaaggggtc agcatcggcc ggctccacaa 7860 gcagcggaag cctgaccggc ggaaacgctc tcgcccctac aaggccaagc gccagtgagg 7920 actgctggcc ctgactctgc agcccactct tgccgtgtgg ccctcaccag ggtccttccc 7980 tgccccactt ccccttttcc cagtattact gaatagtccc agctggagag tccaggccct 8040 gggaatggga ggaaccaggc cacattcctt ccatcgtgcc ctgaggcctg acacggcaga 8100 tcagccccat agtgctcagg aggcagcatc tggagttggg gcacagcgag gtactgcagc 8160 ttcctccaca gccggctgtg gagcagcagg acctggccct tctgcctggg cagcagaata 8220 tatattttac ctatcagaga catctatttt tctgggctcc aacccaacat gccaccatgt 8280 tgacataagt tcctacctga ctatgctttc tctcctagga gctgtcctgg tgggcccagg 8340 tccttgtatc atgccacggt cccaactaca gggtcctagc tgggggcctg ggtgggccct 8400 gggctctggg ccctgctgct ctagccccag ccaccagcct gtccctgttg taaggaagcc 8460 aggtcttctc tcttcattcc tcttaggaga gtgccaaact cagggaccca gcactgggct 8520 gggttgggag tagggtgtcc cagtggggtt ggggtgagca ggctgctggg atcccatggc 8580 ctgagcagag catgtgggaa ctgttcagtg gcctgtgaac tgtcttcctt gttctagcca 8640 ggctgttcaa gactgctctc catagcaagg ttctagggct cttcgccttc agtgttgtgg 8700 ccctagctat gggcctaaat tgggctctag gtctctgtcc ctggcgcttg aggctcagaa 8760 gagcctctgt ccagcccctc agtattacca tgtctccctc tcaggggtag cagagacagg 8820 gttgcttata ggaagctggc accactcagc tcttcctgct actccagttt cctcagcctc 8880 tgcaaggcac tcagggtggg ggacagcagg atcaagacaa cccgttggag cccctgtgtt 8940 ccagaggacc tgatgccaag gggtaatggg cccagcagtg cctctggagc ccaggcccca 9000 acacagcccc atggcctctg ccagatggct ttgaaaaagg tgatccaagc aggccccttt 9060 atctgtacat agtgactgag tggggggtgc tggcaagtgt ggcagctgcc tctgggctga 9120 gcacagcttg acccctctag cccctgtaaa tactggatca atgaatgaat aaaactctcc 9180 taagaatctc ctgagaaatg aaccctcctg tggttgctgg cctgagatat ggaggctggg 9240 ccttactaga cctcatgggc ctagggccct gggaccagaa aggtaagaag tatatgatcc 9300 tt 9302 <210> 2 <211> 4921 <212> DNA <213> Homo sapiens <400> 2 ctcagagcaa tgtcaagcgg tcacgtgtga tagcaacaga tcacgtggct gccatcgccc 60 ctccgccccc ttacactctt cgccctcctc ccagtcgaag cacctcctgt ccgcccctca 120 gcgcatgggt ggcggtcacg tgcccagaac gtccggcgtt cgccccgccc tcccagtttc 180 cgcgcgcctc tttggcagct ggtcacatgg tgagggtggg ggtgaggggg cctctctagc 240 ttgcggcctg tgtctatggt cgggccctct gcgtccagct gctccggacc gagctcgggt 300 gtatggggcc gtaggaaccg gctccggggc cccgataacg ggccgccccc acagcacccc 360 gggctggcgt gaggtaagtg cagtcccttc ccaggaatga gaaccagtgc ccgcccccct 420 cacagctttc cacgcgttcg tttcgcgagc tggttatgga agggtcgctc aagggcggga 480 agtggggcct ttgtggtcat gggaaagtat aattttaggg actgaggtgt aggatcttcg 540 atgcaaggca tgtgtcatgt gtgatctttg tgcggggcgc gattgtccca aaggaaaaag 600 cgttttctat tgcagggcct cacgtggctg gaggggttgg tattgagtca ttgtgttatc 660 tctggggccg gccccaagga agactgggag cgggggatgg gatgctggtg gtgttctttg 720 cgcttttttt ttgggagtcc ctttgttgct gcaggctcat accatcctaa ctctgtaagc 780 gacttttggt gataggagtc tgtgattgta gggtctccct tgatctgaga atggctacct 840 ctcgatatga gccagtggct gaaattggtg tcggtgccta tgggacagtg tacaaggccc 900 gtgatcccca cagtggccac tttgtggccc tcaagagtgt gagagtcccc aatggaggag 960 gaggtggagg aggccttccc atcagcacag ttcgtgaggt ggctttactg aggcgactgg 1020 aggcttttga gcatcccaat gttgtccggt gagaaggtgg tggagggttg ggcgtgggga 1080 gtaaagggaa aagacagcct ataggtgggg tgtgatgatc tgtagagaag tggggaccct 1140 gaggaaataa tgagaggcca tgttgggtta aaggggattg aaaagtgagc atttactctg 1200 gtcaggctga tggacgtctg tgccacatcc cgaactgacc gggagatcaa ggtaaccctg 1260 gtgtttgagc atgtagacca ggacctaagg acatatctgg acaaggcacc cccaccaggc 1320 ttgccagccg aaacgatcaa ggtgagtggg gttggtaggc attgagaggt ggattgggac 1380 ctttgtagta gaaccttctg ggatttcagg tatggtgcct agtttccagt gcatctgtac 1440 ctcccctttg aaactaggat ctgatgcgcc agtttctaag aggcctagat ttccttcatg 1500 ccaattgcat cgttcaccga gatctgaagc cagagaacat tctggtgaca agtggtggaa 1560 cagtcaagct ggctgacttt ggcctggcca gaatctacag ctaccagatg gcacttacac 1620 ccgtggtcag tagaaagatg gtaccaaaat gggttctggt tgggagtagg agagtgattg 1680 cccgtagcaa ttgagaagtc atgtgcttca tgtgttcagt caagcaagtt gtgtttcatg 1740 gtaacccatg gggtccccat ccattcttcc tattcccttt aggttgttac actctggtac 1800 cgagctcccg aagttcttct gcagtccaca tatgcaacac ctgtggacat gtggagtgtt 1860 ggctgtatct ttgcagagat gtttcgtcga aagtatggga cccacatacc ctggactacc 1920 ttgaattccc caaatcgctt gttcataaac cacatccata ccttgcccat tctttttttt 1980 tgagaccagg gcttgctgtg ttgcccaggc tggattgcaa tggcatgatc acagctcact 2040 gcagcttcaa cctcctgggc tcaagtgatc ctcccatctc agcttcccaa ctagctgaca 2100 ctacaggcac gcacctccat gcttggctag tttgttaata tttttataga gatggggtct 2160 cagtatattg cccaggctgg tcttgaactc ttgcactcaa gcaatcctcc cacccctacc 2220 tcccaaagta gcataagcta ctgcatctgg ccccattctt ttacttgcgt actactaact 2280 tgcccatagc agaaagctct gaaatgttct ggaattagga acttcatatc cctttattct 2340 ctttattttt tatttattta tttatttatt tatttattta tttatttatt tattgagata 2400 aggtttcact ctgtcaccca ggctggagtg cagtggccca attacagctc actgtagcct 2460 ctacctcctg ggctaaagca atcctcccat ctcagcctct tgagtagctg agactacagg 2520 tgcacgccac catgactggc tttttttttt tttagatgga gtcttgctct gtcgccaggc 2580 tggagtgcag tagtgcgatc tctgctcact gcaacctcca cctcccagat tcaagcaatt 2640 ctcttgactc agcctcccaa gtagctggga ccacaggtgc acgccaccat gctcagctaa 2700 tttttgtact tttagtaatg acagggtttc accatgttgg ccaggatggt ctcgatctct 2760 tgacctcatg atccacccac atcagactcc caaagtgcta ggattacagg cgtgagccgc 2820 tgcacctggc atttcttttt ttttaaaaaa agagacaagg tcttgcttgc ccaggctgat 2880 ctagaactcc tgggctcaag cagtcctctc acctcagcat cccaaagtgc tggaattgtt 2940 ggcctttatt ccctatactt cctattttga gccactaagc agtaaccatt caactaagat 3000 atctttgaaa atgactgcta ccttatatcc cttctcacct taggcctctc ttctgtggaa 3060 actctgaagc cgaccagttg ggcaaaatct ttgagtaagt gaccaacatg ggagaaaaag 3120 attttctatt ctgagtcctc tttctgctga acccaggatg gcaactggct ctgcccatgg 3180 ggatgggaac tggaggaccc tcctgaccag agttctcctg tcccccacag cctgattggg 3240 ctgcctccag aggatgactg gcctcgagat gtatccctgc cccgtggagc ctttcccccc 3300 agagggcccc gcccagtgca gtcggtggta cctgagatgg aggagtcggg agcacagctg 3360 ctgctggtac tggagatggc tgtgggcaca gggaaagaaa tagagactgg ggaaagaaat 3420 agagcagtat gcagggccct ggccactgtg gttaatgaaa cttggttggt agatgggctg 3480 tagtttttat tacagctgca aatagccacc cacagagaag gatatagaag agaacccatc 3540 ctggctgggc acggtggctc acgcctgtaa tcccagcact ttgggaggcc aaggtgggcg 3600 tatcacctga ggtcaggagt tcgagaccag cctggccaac atggtgaaac ctcgtctcta 3660 ctaaaagtac aaaaataagc cgggggtggt ggcacacgcc tgtaatctca gctacttggg 3720 aggctgagat aggagaatca cttcaactca ggaggcggag gttgcagtga gctgagatca 3780 taccattgca ctccagcctg ggtgatagag cgagactccg tctcaaaaaa aaaaaaaaag 3840 aaaaaagaag aaagctcatc ccaggtattg ttgtgggtgg gcagaagtct gttttcttca 3900 tggttttctg acctttgcct ctcccctcag gaaatgctga cttttaaccc acacaagcga 3960 atctctgcct ttcgagctct gcagcactct tatctacata aggatgaagg taatccggag 4020 tgagcaatgg agtggctgcc atggaaggaa gaaaagctgc catttccctt ctggacactg 4080 agagggcaat ctttgccttt atctctgagg ctatggaggg tcctcctcca tctttctaca 4140 gagattactt tgctgcctta atgacattcc cctcccacct ctccttttga ggcttctcct 4200 tctccttccc atttctctac actaaggggt atgttccctc ttgtcccttt ccctaccttt 4260 atatttgggg tcctttttta tacaggaaaa acaaaacaaa gaaataatgg tctttttttt 4320 ttttttaatg tttcttcctc tgtttggctt tgccattgtg cgatttggaa aaaccacttg 4380 gaagaaggga ctttcctgca aaaccttaaa gactggttaa attacagggc ctaggaagtc 4440 agtggagccc cttgactgac aaagcttaga aaggaactga aattgcttct ttgaatatgg 4500 attttaggcg gggcgtggtg gctcacgcct ataatcccag cacgttggga ggccaacgcg 4560 ggtggatcac ctgaggtcag gagttcgaga ccagcctgac taacatggtg aaaccctgtc 4620 tctactaaaa atacaaaatt agtcaggcgt ggtggtgcac acctgtaatc ccagctactt 4680 gggagactga ggcaggagga tcgcttgaac ccgggaggca gaggttgcgg tgagccgaga 4740 tcatgccatt gcactccagc ctgggcaaca gagcaagact ctgtgtcaaa aaaaaaaaaa 4800 gaatatagat ttttaaatgg cttttacttt tatattcgct aaactttctc aaactggatc 4860 ctgcttatta caggaaagag ttcttggttg ttttctcctt ggccctatcc ctgatttacc 4920 c 4921 <210> 3 <211> 40779 <212> DNA <213> Homo sapiens <400> 3 gcaggaccaa ccgcgccgcc aggccggcca tcctttctcc ctggctcgcc gccgggggag 60 gagcttagga gtatgaagct tccacttccg gagtaaccgg aagttcctgt gttctttatt 120 ctactctccg ctgaagtcca cacagtttaa attaaagttc ccggattttt gtgggcgcct 180 gccccgcccc tcgtccccct gctgtgtcca tatatcgagg cgatagggtt aagggaaggc 240 ggacgcctga tgggttaatg agcaaactga agtgttttcc atgatctttt ttgaggtagg 300 gctgtttact gtcaccaccc ctgtcggatt ttacttccta aacgtacctg taactatcca 360 cttctctcca tctcttctgg caccaccctg gttaaagaca ccatcatgtg tcgccaagac 420 agccgcagta gcttcttaat ggctctccct gcctctactt ttgcctcttc caacctgcgc 480 tccattttga aaaattaaaa tttgcccata tcactttttt tttcttaaaa ttatttactg 540 gctcccaatt accttgggta aaatacagtc tccacaaacc ctgcctgatt tggcccctgt 600 ccactggtct ccctcactcc cttgctccag acccgcttca gagggctatg tccctcaagc 660 ttcctgactg cctggcctgg tctgaatcac tcactcttct tttttcttct agtcgcaatt 720 gaagtaccac ctcccgaggg tgattgcttc cccatgcggg gtagaacctt tgctgtcctg 780 ttcaccactc tacctccagc acagaatttg gcttatggta ggcgctaact gcgtttgttt 840 gttcttctgt ttaatgaatg aacagcatac atcaacataa gaacttgaca aatccagggc 900 tgtaaaatca tcagtatggt tctgcactga gatcggagag aagtaatatt tctaggaaaa 960 ttaggaaccc tgggaacagg acgcttgctt tagtatcctc tccctgctca cctcccctgc 1020 actcccatca gcaccgaccc acacccaatc tcatagaagc cttgtagcta aggatcaccc 1080 tttctcctcc cccactctcc tcaccccttg tcaacttttc tttttcgtcc tgggggttgg 1140 aatgagtaag aagtagcctg ggattccatt cactcactta acaaacattt ctgagtcctt 1200 agctctagca ccttgctaag caaggcaaaa tctccaggag gcaccattca cattgcattt 1260 tctgtgaatg gtgctctggg gagcagcatt cacattgcct tttctgtgaa tggcaaattc 1320 ttccagttaa atataacatg aatagtgtcc cctggagttg accacccaac tgatactgac 1380 tgagaagctg aaatgaacaa aacaacccct tagccctcca ggagctgacc ggaaatccag 1440 tgctaatact actttgcatc ttacagatta gttcttttac aatactgttt ttttttcttt 1500 tttcatttca ttttgtcctt tctgtgactc tgggatgagt ctttttatga ggatcctcat 1560 ataaagatgg acattagga ttaaagagga tgaaatcctg acaaaatagg gagtctcccc 1620 tttagaaaat tcctaagtaa ggctgggggt ggtggctcac gcctgtaatc ccagcacttt 1680 gggaggccga ggcggacgga tcacctgagg ttaggagttt gagaccagcc tgaccaacat 1740 ggagaaaccc catctctact aaaaatacaa aattagttgg gtgtggtggt gcatgcctgt 1800 aatcccagct actcaggagg ctgaggcagg agaatcgctt gaacccaggg aggcagaggt 1860 tgtggtgagc caagattgcg ccatcgcact ccagcctggg caacaagagc gaaactcaaa 1920 aaaaaaaaaa aaaagaaaaa gaaaattcca attttgaagg cctcatccta tattatgtca 1980 aacatactga aatgcagtaa cgccccacat taaataagat ttataaataa ctatacatat 2040 atataattca atctaattgc tgttaatagt tgacatattg ctacatttat atacatttag 2100 ttaaaaaaaa ttttttttcc cagacagcct ctcactcttt cacctagact gaagtgcagt 2160 ggcatgatca cgactcactg caacctcaac ctcccagact caagtgatcc ttccatctca 2220 gcctcctgag tagctgggac tgcagcatgc gccactatgc cctgctaatt tttttaattt 2280 tttgtagaga cacggtcttg ctatgttgcc tagactggtc tccaattcct gggctcgagt 2340 gatcctcccg cctcaacctc ccaaagtgct gggattacgg gcgtgagcca tgccacacgg 2400 ccataaaata ttaattttcg cagctttctt atattttaga actaacaatg gaaatttgtt 2460 cgggtctaaa gtatttcaga ggtccttgaa aacccatgcc tacatacctg atggaaaaag 2520 caatcctagg ttaatggtgg aagtgggagt agagacttct gttctgttga cttcttggaa 2580 gatggggtac tgtctctctg ggacagctct tgagaatttc cctgccagca cagccccaga 2640 taacaatctc tagatggcga ttacctggcc tctcttccca actttctagc ctggagcccc 2700 tagttctccc ctgagcctcc ttagcttgtc cttcttccta acttgtattt ggcttcagat 2760 gtgatccaca gtctgaaaag tcactaattc attccttcaa ctcaggctta ttgagtcctc 2820 ctgtgtatca gccattgtac tcatggggga aaaaaaagac aaagcatatg ttaatagtag 2880 agtgtgctgg acaggcacag tggctcatgc ctgtaatccc agcactttgg gagggcgagg 2940 caggtggatc atctgaggtc aggagttcga gaccagcctg acctaacatg gagaaactcc 3000 tgagatcgtg ccattgcact ccagcctggg caacaagagc aaaactccgt ttcaaaaaaa 3060 aaaaaaaaag tatagtgtgc taaaggctca acggcaagct gaccatgttc tagatcaaa 3120 attggtagag agtctacaat gtgggttcct tattcatcaa atgtttatta agtttaccat 3180 gtgcaagtct ctgggaacag agtgatgaac aaggcactgt acttttcatg gtcagaggag 3240 ggaaacaggc cataaacaag tgtcaaacaa aagactgaag ccaggtgcgg tggctcacat 3300 ctgtaatccc agcactgtgg gaggccaagg caggcggatc atgagatcag gagatcgaga 3360 ccatcctagc caacatggtg aaaccccatc tctactaaaa atacaaaaaa attagctggg 3420 catggtggca cgtgcctgta atcccagcta ctccggaagc tgaggcagga gaattgcttg 3480 aaccagggag ttggaggttg cagtgagcct ggattatgcc actgcactcc agcctggtga 3540 cagagcgaga ctccatctac attaaaaaaa aaaatatata tatatatata tacacacaca 3600 cacacacaca cacacacata ccctctaacc caggaatttc actcctaggt atacctacat 3660 aagctccagt atacctaaac aagtgcaaat ttgtttaagt acagttattt gtggtagcat 3720 tagtcattgt tttcaatagc aagaagaaaa aggaaacaac taaatgtcca tcaataggga 3780 atgaattata ttaatggagg gagagccata caatggaagg ctgaacagaa attaatagga 3840 atggggcaga tttgtaatgt actagcatgg taaaaccttc atgatagata tagatataga 3900 tatatagata gatatagata tatatacata tacatataca tatacatata catatatata 3960 tatatatata tatatctctt gtgtctcagc ctcccgagta gctgggatta caggtgtgtg 4020 ccaccacatc cggctaattt ttgtattttt tagtagagac agggcttcac catgttggta 4080 aggctgtctt gaactcccga cctcaggtga tccacctgtc tcagcctccc aaagtgctgg 4140 gattataggc atgagccatc acacctggcc aaatattttt gataagtatc aagtgcacag 4200 tgcagaacaa aatatgtgtg tgtgtatgca tgtgtatgta cacctataca cttatataca 4260 gtaccccatg tgaagaaaaa taagggtacg tgttatgcgc gtagtattat ggttgttatt 4320 tttgagaata tatctagaaa gataaaaaag aaagtggaaa tagttcttgc ctctggtggg 4380 aagtgggact atgtgcctga tcaataggga agtaaggaac actttttttt ttttttttta 4440 aacggagttt ttgctcttgt tacccaggtt ggagtgcaat ggcgcgatct tagctcactg 4500 caacctctgc ctcccaggtt caagcgattc tgctgcctca gcctcctgag tagctgggat 4560 tataggcatg cgcctccacg cctggctaat tttgtatttt tagtaaagat ggggtttctc 4620 catgttggtc aggctggtct tgaactcccc acctcaggtg atccgtccgc ctcagcctcc 4680 caaagtgcta ggattacagg cgtgagccac cgtgcctggc caggaacgct ttttattttt 4740 gtacctttaa aagtgtgtac cgtctgtgta tataatcagt taaaaacaaa gaaaagctga 4800 gtgtggtggc tcatgcctgt aatcccagcc cttaaggagg ccgaggccgg cggcagatca 4860 cctgaggtca ggagttcaag accggcctga ccaaaacggt gaaaactcat ctctacaaaa 4920 acataaaaat tagccaggca tgatggcaag tgcctgtaat cccagctggt tgggaggctg 4980 aggtgggaga cttgcttgaa cctaggaggc agagattgca gtgagccaag actgtaccac 5040 tgcactccag cctgggcaac agagcaagtc tctgtctcaa aacaaaaaca aaaacacaaa 5100 gaaaaaatgt aaaacaattt catgcagtag caagcatcga gttaaataca gttgaccctt 5160 gaacaacaca ggtttgaatt gcacgggtcc atttatactc acatttcttc cacctctgcc 5220 acccccaaaa tagcaagacc aaccccatct cttttccttt ctcttccccc tcctcagcct 5280 actcaatgtg aagatgatga ggatgaaaac ctttgtgatg atccacttcc acttaatgaa 5340 tggtaaatat gttttttctt acttatgatt ttcttagtag cattttcttt tctctagctt 5400 cctttattgt aaaaatacag tatataacac atatcacata caaaatgtgt gtaaatggac 5460 tgtttgctat tgataagtat tctggtaaac agtagactat tagttttttt tgttttgtga 5520 caaggtctcc ctctgtcgcc cagcctggaa tgccgtggtg tgatcatggc tcactgcagc 5580 caaaaacttc tgggctaaag caatcctcta ctaaaaatac aaaaattagc caggcatggt 5640 ggtgcgcttc tgtaatccca gctactcagg aggctgaggc aggagaattg cttgaacccg 5700 ggaggcagag gttgcagtga gctgagattg caccgttgca ttccagcctg gacaacagag 5760 cgagactcca tctcgaaaat aaaataataa taataataat aataataata ataataataa 5820 tagggctggg tgtggtggct catgcctgta atcccagcac tttgggaggc caaggtggac 5880 agatcacctg aggtcaggag tctcaattaa aaaataaata ggccgggcac agtggctcat 5940 gcccataatc ccagcacttt gggaggccga ggtgggcaga tcacctgagg tcaggagttt 6000 gagaccagcc tggccaacac ggagaaacgc tgcctctatc aaaaatacaa aaattagctg 6060 gatgtggtgg tgcatgctat aatcccagta ataccagcta ctcggaaggc tgaggcagga 6120 gaatcactcg aatccgggac acggaggttg cagtgagccg acatcatgcc actgcgctcc 6180 agcctgggtg acagtgagac tctgtctcag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 6240 aaaatatata tatatata 6300 tatatacaca tatatatgtg tatatatata tacacacaca catatatatg tgtatatata 6360 aaataaaata aataataata aaacatttac tttggctgct gttgctgcgg ggagaattgc 6420 agggtgtcaa aagtagcact ggtggagggg tagtgatcaa agtctggtgc tttagcccaa 6480 aggagaaatg atagagactc agactagctg gtgatggagg tagaataagc ataaatgtat 6540 caaaaagagg agttgataga tcttaaagaa tgattggatt tgaagggcaa aggaagagaa 6600 gaatcaacca ggtgggttca gtgaatgaaa ccatcagaaa cgaattgtcc cctgaaatca 6660 agactttgtg attgccatag ttgtatgctt ctcaaaggtt cctcgtctcc tcttccttgg 6720 accaaaagtc agaggcaaga atgccctcat tcatacccca gtggtctata cctccagcag 6780 caagtcgagt gagcaagtga tgtcctgaaa ggcccagtgg atcagtggaa tgaagcgggc 6840 aggaagactt agtgctcctg aaacaaggaa tccagaatcc aggagaagga tggctcagtg 6900 gggctttcaa gggacaagta tgggggttga aggggtcact gtccctatac caaatccgaa 6960 aatattgtga ccaggaacca ttctgtccaa ctcttctatt tcaggtggca aagcaaagct 7020 atattcaaga ccacatgcaa agctactccc tgagcaaaga gtcacagata aaacgggggc 7080 accagtagaa tggccaggac aaacgcagtg cagcacagag actcagaccc tggcagccat 7140 gcctgcgcag gcagtgatga gagtgacatg tactgttgtg gacatgcaca aaagtgaggt 7200 gagtcgcagg acagaagagt gctttttgtt tcagcagagc agcctgggga gagataaaag 7260 ctactcctgg ggcctgggcc tgcattcctg agatgtgggt aagaggggcc cagggtcaga 7320 gtgtctggca agcttggctc tgcccctttg ctgtcctgga gactagggct aatcctgggc 7380 tcagggagtg gcctccccat ggttaggata caagtgctca tcaagggcca cccctaggaa 7440 ggaccaattt tcctatcaga agcttctaag ttatcctcct ttggcccaaa gggacacctc 7500 aagcctactc tgaggaactc tttccaatga actaattcct acagtcactt ccccagcaac 7560 ctgtgcctca gcctcaaggc actgtggggt aggcctcagt ttgtggcctg gacatcggac 7620 tgtggaccag acgactcctc ccgatttctg tttgttttca gtcctctgac cccaagctgg 7680 ctggtgaagt aggtagaggg aggagacttt ggtgcatgca tacacacaca cacacacaca 7740 cacacacaca cacacacaca cacacacaca cacacgtctc ctgtgccccc cagtctccat 7800 ggctggtcaa tgattgactg gcatttcaca ggccgctggt tgcagcccca gcctgttgac 7860 ttagaggtca ccctcggaag ctagagccct gtcctgcctc ttcagtgtca gtggtcactc 7920 cactgcccac aggctggggt cttgggcaaa acacacgcat ctgccctgat ctgagtttgc 7980 tgccctctgt cccgcagtca gccccactct gttcccactc cctctcccca gcccccctagc 8040 tagacccctc tcaccagcac ccctttccct tccctgaggg tccccctcgc tgtctttgtc 8100 cctcagacat cctctttcct gggctctcct gccaggccct gctggaggga cagttaagga 8160 ggaaatcgaa tcagcagcgc ccacccctgc cccccttcct ctcctcttgt cagacaccag 8220 acgaggtttt ttcctctggc ttcccagctc tgaatgggct cattcttttt cagaggctcg 8280 gcccctctcg agcctcctcc ccagggcgtg agttctgacc ccagctcctc cccccatccc 8340 cactccagcc ccctctccag cttgctccac cctctctacc gcccaccggg actgggcatt 8400 gtctgccagt ccgggtttct tcctgggatt tgggatgcag agaggatggg tttgcttggg 8460 cgggggggtg gagagtgaag gggggaagca ggatctttgt agagggaggg acctacagtt 8520 acctggactt ctttcctctg tctcccctct tggtaccctt gactggggct cttgagggta 8580 atgggtgaag ccaaatctgc catggctcag ttcccagctc agctctgtga ccttgggaaa 8640 gttcctttag ctcgtggaat ctcaaggctc aaggttcctc ttctgcaaaa tggggaatga 8700 taacacctgc ctcctctgga gtcttgggga ctcagtgttc tgaggaacgt ggctgtaggt 8760 cagagtggca cagagtaggg tccaatgaag catggcgtcc acagtagctt tcctgactgg 8820 actaaccttt ccggacacaa cagcagggca ggggtggggc ctggggagaa aggacacctc 8880 taaccctgat cctaacatcc cgatggcctc taaggctgcc tgcacactca tccaggtgca 8940 agccctccaa ggtgtggtgt gatgaaccag tgactcctgg agccaggtca gcgcatcctc 9000 ttcccgcagg gctgtaagct gcaggactga gaggcaggtt gaccaggtcc tgggctggat 9060 gatggggtga gagtaagggg tcagttttga tacatgccca acttttctct ctagccctaa 9120 gacatcctgg gcaaattgct tacctcagtt cccctgatcc tcaccctaac cctaacacca 9180 gctcaagaga aaatagggat attgatggcc atccagaagg gctgctgtgt tccatacaca 9240 gcaatatttc tcgaatgttt gtgacagcgg tccaaggaat aagttaattt tacattatca 9300 ctctggatac ctgtacaaaa ctccacctta tccttactat atgaatgtgc tagggttgtt 9360 tttttgtttt gttttttttt tttttttttg agacagagtt tcgctcttgt tgcccaggct 9420 ggagtacaat ggcgcgatct tggctcaccg caacctccgc ttcccaggtt caagcgattc 9480 acctgcctca gccttcccga gtagctggga ttacaggcat gcgccaccat gcccggctaa 9540 ttttgtgttt ttagtagaga cagggtttct ccatgttggt caggctggta ccaaactccc 9600 gacctcaggt gatccacctg ccttggcctc ccaaagtgct gcaattacag gcatgagcca 9660 ccgcacccag ccgtgctagg gtctttttct gttcaattcc tttctctctc ttgctctctt 9720 tctttctttc aatggagtct tactctgtca cccaggctgg agtgcagtgg caagatctca 9780 gctcactgca acctctgccc tctgagttca agcaattctc ctgcctcagc ctcccgagta 9840 gctgggatta caggtgcctg ccaccacacc tagttaattt ttgtactttt agtagagatg 9900 gggttttgtc atgttggcca ggctggtctc gaactcctga cctcgtgatc tgcctgtctt 9960 ggcctcccaa agtgctggga ttacaggcat gagccgccat actcggccaa ctttgtatta 10020 ctttcttaaa gagagtttcc caaattatat aagcttcagg ccccacaaaa cctagatctg 10080 ccccagtata actaaatctg ggaccattta ttgagcaatt attatgtgcc aagtattgcg 10140 ctgagtgctt ccagagcatt atctccttta accccagcat agtatgtcag atgctgtttt 10200 acagatgagc caactgagac cagagatgct cagtcacttg cccaaggtga catgactgat 10260 atggaataga gtcaagattt tttttttttt ttttgacacg gagtctcact ctgtctccca 10320 ggctggagtg cagaggcgca atctcagctc actgcaagct ctgcctccca ggttcacgcc 10380 attctcctgc ctcagcctcc tgagtagctg ggactacagg cacccgccac cacacctggc 10440 taattttttg tatttttagc agagacaggg tttcaccgtg ttagccagga tggtctcgat 10500 ctcctgacct cgtgatctgc ctgcctcggc ctcccaaagt gctggaatta caggtgtgag 10560 ccaccgcgac tggccagatt caagatttga acccaggtcc tcttggtccc agaggcccct 10620 gtttctcaac tccctaggat ggcatagcaa cctgtcccac aagaggtgcc tgctttaagt 10680 gtgctcagca catggaagca agtttagaaa tgcaagtgta tacctgtaaa gaggtgtggg 10740 agatgggggg gagggaagag agaaagagat gctggtgtcc ttcattctcc agtccctgat 10800 aggtgccttt gatcccttct tgaccagtat agctgcattc ttggctgggg cattccaact 10860 agaactgcca aatttagcac ataaaaataa ggaggcccag ttaaatttga atttcagata 10920 aacaatgaat aatttgttag tataaatatg tcccatgcaa tatcttgttg aaattaaaaa 10980 aaaaaaaaaa agtcttcctt ccatccccac ccctaccact aggcctaagg aatagggtca 11040 ggggctccaa atagaatgtg gttgagaagt ggaattaagc aggctaatag aaggcaaggg 11100 gcaaagaaga aaccttgaat gcattgggtg ctgggtgcct ccttaaataa gcaagaaggg 11160 tgcattttga agaattgaga tagaagtctt tttgggctgg gtgcagttgc tcgtggttgt 11220 aattccagca ctttgggagg ctgaggcggg aggatcacct gaggttggga gttcaagacc 11280 agcctcacca acgtggagaa accctgtctt tactaaaaat acaaaaaatt agctggtcat 11340 ggtggcacat gcctgtaatc ccagctgctc gggaggctga ggcaggagaa tcacttgaac 11400 cagggaggca gaggttgtgg tgagcagaga tcgcgccatt gctctccagc ctgggcaaca 11460 agagcaaaag ttcgtttaaa aaaaaaaaaa agtcctttcg atgtgactgt ctcctcccaa 11520 atttgtagac cctcttaaga tcatgctttt cagatacttc aaagatcca gaagatatgc 11580 cccgggggtc ctggaagcca caaggtaaac acaacacatc cccctccttg actatcaatt 11640 ttactagagg atgtggtggg aaaaccatta tttgatatta aaacaaatag gcttgggatg 11700 gagtaggatg caagctcccc aggaaagttt aagataaaac ctgagactta aaagggtgtt 11760 aagagtggca gcctagggaa tttatcccgg actccggggg aggggggcaga gtcaccagcc 11820 tctgcattta gggattctcc gaggaaaagt gtgagaacgg ctgcaggcaa cccaggcgtc 11880 ccggcgctag gagggacgca cccaggcctg cgcgaagaga gggagaaagt gaagctggga 11940 gttgccactc ccagacttgt tggaatgcag ttggaggggg cgagctggga gcgcgcttgc 12000 tcccaatcac aggagaagga ggaggtggag gaggagggct gcttgaggaa gtataagaat 12060 gaagttgtga agctgagatt cccctccatt gggaccggag aaaccagggg agccccccgg 12120 gcagccgcgc gccccttccc acggggccct ttactgcgcc gcgcgcccgg cccccacccc 12180 tcgcagcacc ccgcgccccg cgccctccca gccgggtcca gccggagcca tggggccgga 12240 gccgcagtga gcaccatgga gctggcggcc ttgtgccgct gggggctcct cctcgccctc 12300 ttgccccccg gagccgcgag cacccaaggt gggtctggtg tggggagggg acggagcagc 12360 ggcgggaccc tgccctgtgg atgccccgcc gaggtcccgc ggccggcggg gccagagggg 12420 cccggacgag ctctcctatc ccgaagttgt ggacagtcga gacgctcagg gcagccgggc 12480 cctggggccc tcgggcggga gggggcagtt acacggcagc ggctcgagat ggcccatcca 12540 agagactggc gctttccagg ctccgagggg ctccgggaac ttgtcaaaga agttctctga 12600 aattgttcag aaagttttcc cgcaaagggt gtattgcgta gagcgcgcgc gcgcgtttcc 12660 ccccttcttg agccccctca agctttctca aagcctttcc agttggcagc ctccgcctcc 12720 ggactggcct gggctggatt ccttgggggg gtcctctgcc ctgcccctcc tccagcccct 12780 ccccgctccc cttcagacga ttttggtttg gttgctcctg cttctggcgg ggtcgggtgt 12840 gtgtgtgtgt ggtggagtgg agggtggcat agcaacctgt cccaaccaga gccggggagg 12900 aaagggtggc ccggagggtg gcctcttgct ggggtctggg ttgggggcgg gggagacgtt 12960 tgctttgaac agattcttgg ggccagctta gggactgtgc tctgtgactt ttggagcgcg 13020 tggaccatgg aggggtgggg gtgggtttct tggggtgtaa agtgggagag ttcccagaga 13080 aggaagctaa gaaataaggc cagatgggag cctagggagg gctgcgttgt tctgctgcct 13140 tttccttggt gctgtgcgtg gggaagggtg agtgggggca gtgtgtatcc tgacccatct 13200 gtccacctgt gtgcattaat cataaaagct aacatatagc ctgggccagg tatactctgc 13260 caggaactgt ttgtggtgtt ttgcatgcat tctcctttaa tcctagaaca cccctatagt 13320 ggaagttctg ccagcattct ggactgagta gcagtccaga ggttgagtag cagctagtaa 13380 gtggtggggt caagatggga ccccaggcag tgcgaccccc aaccatgcat tcgaaatcgc 13440 tatatggatg agtgcacctg gagcaatgag ggacactgct ccctgagtca ctgggctgca 13500 ggggagacaa aatgaaagtg ttctgggagt cgtgggtggt ctccataggt cagagggtct 13560 ggggagggag tgggtgtcat cgtggctgtg tgttgcccga ggggccctct gtgagtgagt 13620 gcatggccgt gttatctctg caggtctacg ccagggtgtt cctcagttgt gtggtctttg 13680 tatttgtgtg tctgggcttt gtgttgccaa acagcagtct ctctgctgac ttggggacac 13740 aggctgaact ctgtcctctg caggaactcc cttaaggtgc tgggccagat ctgccataaa 13800 cagagggagg tagccttcta tggccacgcc ttcttgctga ggaagaaggt tcctctcttc 13860 cagggagtac atccttgccc tccctgtttc ccagacaagc atcttcacct ctcatcttct 13920 gatgagaagg gtgaggccat actgagctgt caggctgagc tgctgccctt cctcaccttg 13980 ggctgggagt tgatcaggga atggcagttg ctgcagagct ggatttgagg gctgggttct 14040 ctggatgggg cctcctcatg tcctcacccc tcaacctgca ctattgattg tgttgtgcag 14100 gagttagtta aaaagtcatt gcacagcctg ggcaacaagg caaaactctg tacaaaaaat 14160 acaaaaatta gttggatgtg attacacgtg cctgtagtcc cagctactcc ggaggctgag 14220 gcaggaggat cacctgagcc caggaagttg aggcttgcag tgagctgtga ttgcaaatgc 14280 tctccagcct gggtgacagt gtgagactcc gtttcagaaa aaaagtatac cacccagctg 14340 cctccagcac ccagatttta cccaaggggt gaggtctggg gcaggaatgt gggggaaggg 14400 gaggcctagg gggagcccca gaggggtcag gatttttctg aaatcctttc ttagaggtat 14460 gggttttaca aattgcagca aatacatcct tttaatcttg cagaactcct tcatatttta 14520 attccagtat gattcttcca acagcctcct ctcttacta tacttgggga aagtactcat 14580 tttatttgtc aagaaaaaaa caattgaaaa gatagggatc aaatgtaaaa agaaaaaata 14640 cgtggcattc caaagtcaaa cacaaagcat gtttaatttt ctcgtggttt gggattaccc 14700 atattcctgc tgtatgaacc tgtcttgtct taacttttaa gaaatgtacg gtgtacttcc 14760 tatatgctag gtttttatcc atgctttcat ttaatctctg tgacagtcct gtgaagtagg 14820 tgcacagatg agaaaatgga agttcagaga aatgaagcaa cttatccaag gctcccagct 14880 acccagtaat gtccagggaa tttttggact ctgaagagga ggcattaaga ggtggttaga 14940 gtcttattcc agccaacaat aatgggttga acaaagcctt aggggcaggc aggtggccag 15000 atgggaggag aagcgctcct cttgttcagg cgaatgacct ttccatccac ttctctaggc 15060 tgtagaaagt ggagctgagc tgggggccct gaggttccct cttgacttca gagtcctctc 15120 ccttcctgtc cagccaatgc ctgtcttcct tttgggccct accagcatga cagggggctg 15180 cgggcaggag gggacagagg ccacgttgac acacagggct gtgggtgaga gagacagctg 15240 aagtgtcagc gtgaggggcc agtgtggggc tgcggctggg agggctgggg tggggcccag 15300 ggtagttgtg cctgtccttg ggtgatggaa tgatctggaa agagattcct tccctgccct 15360 ccacctgtga gaagcccctc tagagtgaca tctccatctt atgtttggcc acccatcctc 15420 cccctgggaa gagagccgag gtggggtaag ggatgtgtac tctttcaagg agtgggagaa 15480 ttattctagc gaatgtttgt gttgtcccag ttctgtttac aaagcctcgt catgtttaca 15540 gatggctgcg caattcatta cctcatttaa ctctcatgta cctcctctga gggagtaaga 15600 gctgttacag ccaagtttag gtcagtaaat attcaccaag ttgcaggtac tgcagggcat 15660 agagatgaat ccgatttagc ttctgccctg gaggtctggg aacttgctca agatcactca 15720 gtgagcagct gagctagggt tctcaactaa agaccctggg cccaggccct ggtctgatgt 15780 caggcctgat acaccaggtg tttgtggtcg gggaatccca gtgtcacttg aatgggctgt 15840 gacattatgg gtctgggaga gctgagcttt ggggacacag gtcattttac tgtagtattc 15900 atggaaacca agggaagtat tggcttttct gctgtgagca agaggagcag ctggggctgc 15960 aagctggtgg ggaggagaga acccacctga gagaaacctc aggactgggg tcaagtcctg 16020 accaccagag tccagagaga catgaaggac tgtgaccagc tctgagcaga gagatggatt 16080 ccatgacctc aactggtccc ttttgttcgg agactcgtga ctggacttca ttcatccact 16140 cattcattca ttcactcagc agacacttat ctagcgctcc ctgtggctgg tcctgcctca 16200 tactgtcttt gctctggaga attggaggtt ggggttcctg aggggcaggg tcctggagac 16260 aaggacactc ctgggtagaa ttaggaccta ccccccagga aatcaacggg gaccaggtgc 16320 cgtggctcac acctgtaatc ccagcacttt gggaggccga gacgggcgga tcacaaggtc 16380 agcagttcag gaccagcctg gccaacatgg tgaaacccgc ctcaactaaa aatacaaaaa 16440 ttagccaggt gtggtgtcag gcacccgtaa tcccagctac tgaggaggct gaggcaggag 16500 aattgcttga acccgggagg cagaggttgc agtgagccga gattgcgcca ctgcactcca 16560 gcctggcgac agggcgagac tccatctcaa aaaaagaaaa ccaatgggac agggcagata 16620 tggggacaat ggtaaggaga tggggagagtg ggagggaggt gtcaggaaga ccttcttgac 16680 ttcatgtagg ctggtggggg tgttagccag caagcctcca gttccctggg aaccgttctc 16740 agggtaccaa ttttaccacc tgtctgcaaa cactttaaga ttcttaatca gactcaaatt 16800 ggccacaaat caggtaaaca aactcactag tggggtgggg ctaccacccg ttctgaccct 16860 ccagcccaac ccagcccagc caccctgccc tccgtagagc ctgtggtgtt tatcggtggc 16920 attgggagaa ttagtgtgta tttatgttgg cgtggggtgt ggggtggatt tgtgtgtgtg 16980 cagttaggcc tagtggaagg aatgtgggat ctgaaggcag gccagcctga gttccagtcc 17040 tgcctgttgc tcacaagctt tatgaggcga gagctaaccc ctgccagcct cagttgtctt 17100 ctttgcaaga tggaggttgc agccccagtc tctggagcat gttatgcaga tccaccgaga 17160 gtgcctgcca ggcacacagt aggtgctcag ctcagttact gtggcggccc ccactcccca 17220 ttgttgttgt tttcctattg cctggcggcc acagctggta tcccttgaaa agggctacag 17280 ggggtggagt cggaccctgc cccagccctg tggagaccct gggcttgggc cagggcctgg 17340 ggtctgggcc tgcagacagc tgtgtctata aagcagctga agggctgagg ccgggggagg 17400 tcctggcagc agggcgttat tttgggcctg gcctgccacc cccagctcct gtttctcttg 17460 ggagtctgtt gggggaggaa gtgtggggaa gaggaggggg tgcaagtggg tgaggcatgg 17520 agtggggagg cctccctcag ggacatggac ccttgagttc tatttctgtt cctccctcct 17580 gttcctccct ctttgtcctt atctgcctag agaggtggga atagaggcca ttctgagtat 17640 cactaggaga ccaccagttt gtggccactg gccactggcc caggcaggga acctgggggc 17700 ttgccctacc agcctctccc agcaatctga aggcaggggg tacctcgtat taccccctag 17760 gatttgacct taggctccaa cttgctggga gagcagtgcc tctggtgtca gaccccaagc 17820 cagcccttgt gctgtccctg aatctgcatg tagcctgtgg gaggcggagc agtgaccggc 17880 aggaattctg ggcagctcag gcacctgtgg gcctgagggt gccctctgcc cccacccttc 17940 cgatctcctg ggcaagacac gccaggtgat tcatctcacc agagcagaaa aacaagttca 18000 actgggcact ttaatctccc ctcactggca ggcctggtgt gagctgctac cccggcgccc 18060 ctcaccaggg gtgctttacc tcctctagta ttcctgacct tagtgggcat ttctggtctc 18120 agggatacca ggctggggtc caagtgggcc aggtgtggca gttcagccct atgcccccatg 18180 gctgatggct cgcgctgggc aggtatgcag ggctgacgta gtgcctttgt ggcagcagtt 18240 tcgtggcaca cattctgcca gctggttctg gagtcttgcc ctgaggaggt ggccagggtg 18300 agggtgccag cgcaggaacc tttggcgcat gcttcaccct ggcctgggat ctgcagcctg 18360 ggtccagatg cccacaactg gaatctgacg ctccttttct cttcatgggg gactcccaga 18420 ggtctctgca atgaccagag ccccggttgt cccatgcctc agctgcaact ccagctgacc 18480 ctccttcccc actctctggg tggcattacg ggggtgtgga tcccttgcca agaggttggc 18540 atgtgggtgt gctggaatgg catagggaga atgcaccgag tttgtttgct tgggagaggg 18600 gcagggggta tccagaagat tcatgattcg tcatcgcctc tcttggggga tttttacccc 18660 tttgccctga gttgtgcctt tgggacaaag gaagcctttc tttgccagcc aacaccctgt 18720 actggcgggc gagctcccca gggctggcac gctggggcag cctctgaatg cacagggtgg 18780 gcctagtcag aagaagcctt tcccctgaaa tccctctact tcccaagcac gcaagctttc 18840 tcctgctgtt aaacctgcag tgtgcaaggg acatgggcgg aggggtcctt cagtcaggct 18900 tctccctgtc tgaggtggca tgacttggag tgagtttgga tggggtggcc aggtctgaga 18960 aggtcccccg ccagtgtcct ctgacccatc tgctctctcc tgccagtgtg caccggcaca 19020 gacatgaagc tgcggctccc tgccagtccc gagacccacc tggacatgct ccgccacctc 19080 taccagggct gccaggtggt gcagggaaac ctggaactca cctacctgcc caccaatgcc 19140 agcctgtcct tcctgcaggt gaggcccgtg ggcaacccag ccaggccctg cctccagctg 19200 ggctgagccc tctgtttaca ggtgggtggc agaagaaggt gccctgccct tctgtttcct 19260 ctcttgttgt ggtttctcaa ccaggaagtc ctttctaaca tctaaccccc attcatttta 19320 ctgcagaatc agttgactct ctctataacg tggctggccg aggtcatgtc tggatgggat 19380 gcgtctgtgt ttccgctaaa tcttgtgctc tcttgccagc atgatcatgt cccctgtcca 19440 cctgctccag ccactatccc tctcccactt acagcagaag aaagggctgg tgagaaaggt 19500 ggattacagg cccacttctg ccactgacga gccctatgaa tgtggcctac acccccttag 19560 cttcactggg tctcagtttc cctatctgta tattgggagc agttgtgaag ctcagaagag 1920 aaatgtctgt gaaaaggtta tgaacaggag ggagagtgga aaccaacctg ctggatcgtg 1980 tccacagacc ctggaatggg gccacatgct tggtttgtca aattgcagac gccggccggg 197440 tgcgatggct catgcctgta atcccagcac tttgggaggc cgaggcggac agatcacttg 1800 aggtcgggag ttcgagacca gcctgaccaa catggagaaa ccccgtctct actgaaaata 19860 caaaattagc caggcatggt ggcacatgcc tataatccca gctacttggg aaggctgagg 19920 caggagaatc acttgaacct gggagacgga ggttgtggtg agcctagatc gtgccattgt 19980 actccagcct gggcaacaag agtgaaactc cgtctcaaaa aaaaaaaatt tgcagacgcc 20040 atcccatcca ggcctttgct ttcactgatg aagaaactga gatacagaga gggcagggca 20100 cctgttcgga gtttatgaaa tgccccccca ccattatctt tcttgatcat ataagaatct 20160 ggtgaggcaa ggtagggcgt gatctttatc tctattttat cgttttattt aagcgggaac 20220 aggactgctc agtggctggg ggccttgccc aagatctcca agtactgggg aaccccaggg 20280 aggccctggg gggtggcagt gttcctattt cagccccact ctgcttcccc ctcccaggat 20340 atccaggagg tgcagggcta cgtgctcatc gctcacaacc aagtgaggca ggtcccactg 20400 cagaggctgc ggattgtgcg aggcacccag ctctttgagg acaactatgc cctggccgtg 20460 ctagacaatg gagacccgct gaacaatacc acccctgtca caggggcctc cccaggaggc 20520 ctgcgggagc tgcagcttcg aagcctcaca ggtggccttc accgtcattg aaaccttctc 20580 ttggttattc agagctgacc agggccactg ctaaccaggg ggaggctttg tgtgcattag 20640 aaatggtgtc ccttctgggc agacgcaggc agagcccggg aagacgccct cagaagattg 20700 gaaaaagatt ccccttcttc ctgggaagtt gtagcttgcg tcagcacata taattcaatc 20760 gtgagaatgc aggctgggtt tttgccccca cttggctgag tgaagtgtac agtgaacaac 20820 ctatgtaact atttgctggc cctggagccg actctgcccc agagtctggg tgccaggtgc 20880 tttgcccgca tggcccattt cagtcacgct gcagtcctgt caggaaaaaa tcagtgttat 20940 tctcattcta catatgagaa aactgaggct tgcagatata agggccaaaa gttacacagc 21000 tagtgagtga tggggctgag tttcagactc cacagtctct taaccaccaa gcagcatgcc 21060 cagagtagag gtgagaagga aggagagagc tgcggtccac atgagcatct ggacctagca 21120 tggacaactc actcctccct ggctctcgct ttgttcttgt tgcgggtgtg gtggtggtgg 21180 gactcaaaga cggtaaagat agctttctct cctccctggg gaatctgggg gttgtttaaa 21240 aggcctgctc ctcttttaga aggcaggagg gccccaaggg aagcagaagg tgacagaagg 21300 ggaaagggtc ctctgatcat tgctcacccc acagagatct tgaaaggagg ggtcttgatc 21360 cagcggaacc cccagctctg ctaccaggac acgattttgt ggaaggacat cttccacaag 21420 aacaaccagc tggctctcac actgatagac accaaccgct ctcgggcctg taagccatgc 21480 ccctccctgc tgcctcttct ctcagacagc ctgaccccag ccgcaaactc ccaacttaca 21540 acccagtgcc tgcccgccac tgccccagcc gcctacacca cccatttcct ccctctctgt 21600 ccctcctgcc atctccctgt gcctcttcat ctctggggtt ctctgtcttg tctccctctg 21660 cttataggtt gtgcctctgg tttgggggcc tctcagcctg tctgggtccc tcccttgctg 21720 tgcagttggc ctcgtggcct ctgctgctgt ttgtgcctct ctctgttact aacccgtcct 21780 ctcgctgtta gacatctctc tcactgcctg tctctggttc tgtcctcagg ccacccctgt 21840 tctccgatgt gtaagggctc ccgctgctgg ggagagagtt ctgaggattg tcagagccgt 21900 gagtctcagg gaggcctgga gtcagggaag gggagggctg gggccgggtg gaatgcaggt 21960 gtcatacagg tgacatggga ggggtgggat aacaggcttg ggatgtctcc cctgggccag 22020 gtagtctccc tagaaggtga tgctgatgag ggtctggtgc ccagggcgcc actcagccct 22080 catcctgccc tttgcccaac agtgacgcgc actgtctgtg ccggtggctg tgcccgctgc 22140 aaggggccac tgcccactga ctgctgccat gagcagtgtg ctgccggctg cagggggcccc 22200 aagcactctg actgcctggt atgtgcctct gctttgtgcc caatgtgctc taccccccag 22260 gatgcaaggg gtgggcaccc tgcctggtac tgccctattg cccctggcac accagggcaa 22320 aacagcacag tgaaagccag ccacctgtcc ccccaggcct gcctccactt caaccacagt 22380 ggcatctgtg agctgcactg cccagccctg gtcacctaca acacagacac gtttgagtcc 22440 atgcccaatc ccgagggccg gtatacattc ggcgccagct gtgtgactgc ctgtccctgt 22500 gagtgccagg gagaaacaca gttttctcat tttggtgggg aggtttgttt ctgtaaatgg 22560 gagcatatgg ggagcactgt ctgcatcttg ctttgagagc tggtcatgac agttcctgcc 22620 gagctgcctt gttctttcaa cagctgtgga gcaggtggca gtaaggagag gcagctaaga 22680 gcccagactt gggagccaga ctgcctgggt ttgaaaccca gctctatcaa ttagtaggca 22740 cgtgaccctc ttgctgtgcc tcagtttcct catcagtaaa atgggggcaa gaatagtccc 22800 aactgcataa gatggttata acatttgaaa gagttaatat ttgtaaagct cttagaacgg 22860 tgcctggtat gtactaagtg ctcctaaatg ttagctttta ttctatagcc tggtgaggtc 22920 agttttacct ttcgttttgt ttttgagacc gaatttagtt agctctatcg cagtggcgcg 22980 atctcggctc actgcaacct ccgcctccca ggttcgtgct attctcgtgt ctcagcctcc 23040 tgagtagctg ggattacagg cgcccaccac catgcctcgc taaattttgt atttttagta 23100 gagacagggt ttcaccacgt tggccagact ggtctcgaac tcctgacttc aggcgatcca 23160 cctgcctcgg cctctgaaag tgctgggatt acaggcgtga gccactgcac ccggactttt 23220 ttttttttgg cagagtctcg ctccattgcc caggctggag tgcagtggtg caattttggc 23280 tcactgcaac ctctgccttc cgcattcaag caattcttgt gcctcagact cttgagtagg 23340 tggaactaca ggcatgcacc accatggctg ggtaattttt gtatttttag tagagacgga 23400 gtttcactat gttggccaag ctggtctcga actcctgacc tcaagtgatc cacccgcctt 23460 ggtctcccaa agtgctggga ttacaggcat gagccatcgt gcctggccta gctcagtttt 23520 atttaacaga tcacctattt actgatgggc gtttatggac tgggctcaga cctggggaac 23580 ctctttcctc ctctcacagg aacaggagtg ggccttcaga tcctggctga ctgtgttagg 23640 gagaggacaa aatgtagagc cagaccattt gggttcaaat cctcgctcct ccactcacta 23700 gcacaatgac cttgaataat ttacagaact ctctgctttg gtctcccttt ttgcaaaatg 23760 ggaatctcac agtgctgatc ccgtctggtt gttgtgaggg gtaaatggat gtcaggtgct 23820 gatgcgtggt agggcattta agtattggtt gatattattc ttcttgtgcc tgggcacggt 23880 aatgctgctc atggtggtgc acgaagggcc agggtatgtg gctacatgtt cctgatctcc 23940 ttagacaact acctttctac ggacgtggga tcctgcaccc tcgtctgccc cctgcacaac 24000 caagaggtga cagcagagga tggaacacag cggtgtgaga agtgcagcaa gccctgtgcc 24060 cgaggtaccc actcactgcc cccgaggcca gctgcagttc ctgtccctct gcgcatgcag 24120 cctggcccag cccaccctgt cctatccttc ctcagaccct cttgggacct agtctctgcc 24180 ttctactctc tacccctggc ccccctcagc cctacaagtg tccctatatc ccctgtcagt 24240 gtggggaggg gcccggaccc tgatgctcat gtggctgttg acctgtcccg gtatgaaggc 24300 tgagacggcc ccttccccac ccacccccac ctcctcagtg tgctatggtc tgggcatgga 24360 gcacttgcga gaggtgaggg cagttaccag tgccaatatc caggagtttg ctggctgcaa 24420 gaagatcttt gggagcctgg catttctgcc ggagagcttt gatgggtaag agtgggcacg 24480 atgacctgag acagtgtcag ggcagacaga gtcctgagga tccagatgtg gcagcatctc 24540 ttggggatgg caggagacag aagtgggggg atcaagaatg caaagaaagc agatgggaga 24600 ccagaggagc agggcctttg gtgggtgggg gtgattattt ttgtaaatga catgctatcc 24660 gtgaacaagg acttgtatgg aggtcagacc atctagataa agtaaaattc cctttgagtt 24720 catagcagct ttattcaaaa tatccccaaa ttggaaataa ctcaaatgtg catcactagg 24780 tgaaggaata aacaagtggc agtgtatcca tttggtgaag ttctacttag caaccaaagg 24840 aaatgaacta ccgatacaac ataaatgaat ctcagaaaca ttacattgag caaaagaagc 24900 cagagacaag attccatact gtctgatccc ctttatgtga ggctctgaac cgaaaaaacc 24960 actctgtggt gggagagatc agaacggtgg ttgccccagg gtggggggct tcaaaaggga 25020 ggcacacaag gacatttctg gggtaataga aatgctctgt atagtgattg gggtagtgga 25080 tacatgagcg aatccatttg tcaaaactca tcaaactgtg tgataagagt ctgtgcattt 25140 tatttatttc attttatttt ttgagataga gtctcactct gtcagcaggc tggagtgcag 25200 tggtacgatc ttggctcact gcaacctctg cctcctggat tcaagcaatt ctcctgcctc 25260 agtctcctga gtagctggga ctacaggtgt gtgccaccat gcccagctaa tttttgtatt 25320 tttaatagag atggggtttc accatgttgg caaggatggt ctcgatctct tgacgtcgtg 25380 atccgcccac ctcagcctcc caaagtgctg ggattacagg catgagccac cacacccggt 25440 gcattttatt gtatataagt tatacttcaa taagaaatga attggggcca ggcacggtgg 25500 ctcacgcctg taatcccagc actttgggag gccgaggcag gcagatcact tgaggtcagg 25560 agttcaagac cagcctggcc aacatggtga aaccccatct ctactaaaaa atataaaaaa 25620 ttagccaggc ttcctggcat gcgcctatca tcccagctac ttgggaggct gaggcaggag 25680 aattgcatga actcgggagg tggaggttgt agtgagctga gatttcgcta ttgcactcca 25740 gcctgggcga cagagtgaga ccctgtctca aaaagaaaaa aaaaaaaaag ggtcaggcgc 25800 cgtggtgcac acctgtaatc ccagcacttt gggaggctga agcaggaaga ttgcttgagc 25860 ccaggaattc aagaacagcg tgggcaacat agtgagatcc catctctaca aaaaaacaca 25920 aaaaattagc cgggcatggt ggtacgcacc tgtagtctca gctactaggg agactgaggt 25980 gggagaatca cctgagcctg ggaggtggag gttgcagtgg gttgaaatca tgtcactgta 26040 ctccagcctg ggtgacagaa tgagaccctg tctcaaaaaa aaaaaaaaaa aaaaaattcc 26100 ctttcacact tcctttacct ccactcccct ttccagaggg ggccatggtt aacagtgtgt 26160 gtgttcacct agaccgttta tgcatctgta gacacacaca cagtgaagtg tggttttcgt 26220 cgttttggtg gggaggttgg tttctgtaaa tgggaacata tagggagcac tgtctgcacc 26280 ttgctttgag agccggtcat gacagttccc attgaactgc cttgttcttt caatagctgc 26340 agagcaggtg gcggcaagga gaggcagcta agagcccaga cttgggagcc agactgcctg 26400 ggtttgaaac ccggctctac cacttactag gcatgtgacc cttgtgctgt gcctcagttt 26460 cttcatctgt aaagtggggg caagaacagt cccaacttca taagatggtt ataccaccat 26520 gcctggccag atgattataa agtttgaatg agttaatatt tgtaaagctc ttagaacagt 26580 gcctggcaga tactaggtgc tcctaaatgt tggtttttat tatgtggctg ggtggctcgg 26640 ggttttattt aacagctccc ctatttacta atagacattt agatcatgtt ccattttcac 26700 tcttacaaac agttccactt tgtgtgtggc tctgggaaca tgggccagtg tctccctagg 26760 ccacattcct agaaataaga tttcttttct tttttttttt tttttgagac agagtctcgc 26820 tttatcgcca ggctggtgtg cagtagtgtg atctcggctc actgcaacct ctgcctcccg 26880 ggttcaagtg attctcctgc ctcagcctct cgagtaactg ggactatagg cgcgcggcac 26940 cacacccagc taatttttgt atttgtagta gagatggggt ttcaccatgt tggccaggat 27000 ggtctccatc tcttgacttc gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac 27060 aggcgtgagc cactgagccc aggcagaaat aagatttcta gatcaaagga tataaatact 27120 gttttgatag atgttgccga actaaggcct gggctttgaa gcccaggatg ggaacagctg 27180 ggctcgatgg gcaaagggtt tgagtgaagg cattcatggt ggggagtggc tggcatggcc 27240 agtgctggga gtgatgtcca ccctgttcct ggccctgctg actcctctcc tgacccctcc 27300 agggacccag cctccaacac tgccccgctc cagccagagc agctccaagt gtttgagact 27360 ctggaagaga tcacaggtgg gctctgtctc tgcatcctgt tctgcagggg ctgggagtcc 27420 ttgtcctgtc cccactcctt taatctcacc ctctgcctgc aggttaccta tacatctcag 27480 catggccgga cagcctgcct gacctcagcg tcttccagaa cctgcaagta atccggggac 27540 gaattctgca caagtgagca ctgagaaaga gggggcctga tggggaggag tcccagggag 27600 gagtccctgt gggaagcttt gggcctgagg gagtactcct gtagcagtaa cctttccatg 27660 aaagtctgca gagtgtgctg gggatggagg aagatgagaa tagcctttgc tgaccgggaa 27720 ggggtccgtg gtaaggtgcc cacctttctc ccatagtggc gcctactcgc tgaccctgca 27780 agggctgggc atcagctggc tggggctgcg ctcactgagg gaactgggca gtggactggc 27840 cctcatccac cataacaccc acctctgctt cgtgcacacg gtgccctggg accagctctt 27900 tcggaacccg caccaagctc tgctccacac tgccaaccgg ccagaggacg agtgtggtaa 27960 gacagggagc ccagtgtgcg cactccccat ctgccagcac acagcagtgc ccagggggcc 28020 ctggcagcag cgttcttgga cttgtgcaga ctgcccgtct ctgtgcaccc ttcttgactc 28080 agcacagctc tggctggctt ggcctcttgg catggcttct ctagctgggt cctacctgcc 28140 ttggcatcct tccctccccc tctgtttctg aaatctcaga actcttcctc tccctacatc 28200 ggccccacct gtccccaccc ctccagccca cagccatgcc cacagccagt tccctggttc 28260 acttggacct ggggcctccc ctaaaagtcc cctgcggtcc cttcctcctc actgcagtgg 28320 gcgagggcct ggcctgccac cagctgtgcg cccgagggca ctgctggggt ccagggccca 28380 cccagtgtgt caactgcagc cagttccttc ggggccagga gtgcgtggag gaatgccgag 28440 tactgcaggg gtatgagggg cggaggagag ggtggctgga ggggtgcatg gggctcctct 28500 cagaccccct caccactgtc ccttctctca ggctccccag ggagtatgtg aatgccaggc 28560 actgtttgcc gtgccaccct gagtgtcagc cccagaatgg ctcagtgacc tgttttggac 28620 cggtgagctg ctggcgggct cagagctggg tggagggggg cagcgagggg gattgccagg 28680 gacttggcag gatggcgaga tgcagtaggg tgtgctatct ggtaaaatat ccctggagag 28740 ggctcagcgc tcagacctga acagcaacag agtggcagaa aaggggcctg ggggacactg 28800 gggcccttca gactatgaaa aggttctaag gaggtctgtg ttggtggctg tgactgtggc 28860 tgtgctaggg tggtgagccc tgtgggctca ggcgtcagac tacctggatt cagacccagc 28920 tcctgcttcc aaccttggtt ttttattcct aaaatgggta ttgtaataat acctaccttg 28980 ctggggtgtg gcaagaatga aattaaacag ggcttggcac agtgaagcac gggaaaggct 29040 ttctacagag cagtgactgt tgttactcgc tgttacacct taggtaatgc gttttcctct 29100 ctgggtgcct cccattttct ggctcaagtc cctgcccagg atcaagcttg gaggagggcc 29160 ccgagggagg ggccacagag actgggtgaa gagcaagggt gtttgtccca ggagcatggc 29220 gaaaattgct gctgggtggc cttgggaagc acaaagggga cccaactaag ggcctgatcc 29280 tactgccctg ggggtgtcag tgccagcccc ccacaaatct tttctgcccc ccccaggagg 29340 ctgaccagtg tgtggcctgt gcccactata aggaccctcc cttctgcgtg gcccgctgcc 29400 ccagcggtgt gaaacctgac ctctcctaca tgcccatctg gaagtttcca gatgaggagg 29460 gcgcatgcca gccttgcccc atcaactgca cccactcgtg agtccaacgg tcttttctgc 29520 agaaaggagg actttccttt caggggtctt tctggggctc ttactataaa aggggaccaa 29580 ctctcccttt gtcatatctt gtttctgatg acaaaaataa cacattgtta aaattgtaaa 29640 attaaaacat gaaatataaa ttaatgccct agcagttcta tccccactgt taataatttg 29700 aaatattttt cctctagtta tttttgtctg tgcacattct aatatgtata tataagttaa 29760 catatattaa tattattctc cagttatttt tatctgtgca cattttaaca cacacacaca 29820 cacacacaca cacacacata tgtattttta gacggagttt cactctgtcg cccaggctgg 29880 agtgcagtag tacaatcttg gctcactgca gcctccacct cctgggttta agcaattctc 29940 ctgcttccgc ctcctgagta gctgggatta cgggaacgtg ctaccttgcc tggctaattt 30000 ttgtattttt agtacatagg atttcaccat gttggccagg ctggtctcga acccctgacc 30060 tcaggtgatc tgccagcctc ggtcccccaa agtgttggga ttacagcggt gagccaccat 30120 gcccagtcat atatttcttt ttaacaaata gaatcataga tcatacatat tgtttgcaaa 30180 ttgctttttc tcactttcca gaaccttgaa atgtttttcc atgttctaac atggtgatct 30240 accttattct tttaattttt cttatttagt tgtctttaca catgaaacac atgaatacat 30300 ccttgtgata aacattttca gtaacataaa agtataaatg ttacaaagcc aacgtgccct 30360 ttcactcaac tccctgtcca cccagtctct cctgtctgct gggagaacca ccgcattgac 30420 ttgtgtgttc acccttccag gctcttttct gcacacttat atagacatac tacatttata 30480 ttaggtcgag tcaaataaga ttgctgtttg tgtaaaccaa aaagtgtcaa gagcctgggc 30540 gcagtgactc acacctgtaa tcccagcact ttgggaggct gaggcaggca gatcacttga 30600 gatcaggagt tcgagaccaa tctggccaac atagcgagac cccgtctcta ctaaaaatac 30660 aaaaactagc caggtgtggt gatgctgttc tgcactttgc tttccccccg acttgaggta 30720 tcctttcttg tgagtacaga cggatctacc acctttattt tttttttaat tactcaacct 30780 gtaacatgga tgtaatttca ctttgttttt gagggatatt gagcttgttt ccctgttttt 30840 gcagtttatt gcaattgagc tccacacaca agtgagccct cttttgtatg ccccctagtg 30900 ggaatacagt gctggcaatg tttatcacaa ggatatattc atgcatttca atttaaagac 30960 aactaaatga gaaaaattaa aagaatatgg atccaggctg ggcatggtgg ctcacgcctg 31020 taatcccagc actttgggag gccgaggcag gcagatcacc tgaggtcagg agttcaagac 31080 cagcctggcc aacatggcaa aaccccgtct ctactaaaaa tacaaaaatt agccaggcgt 31140 ggtggtgggc gcctgtaatc ccagctattt gagaggttga gacaggagaa ttgcttgaac 31200 ctgggcagcg gaggttgcag tgagacgaga ttgcaccagt gcactccaac ctgggcaaca 31260 cagtgcaact ccttctcaag aaaaaaaaga aaaaaaaaaa gaatatgggt ccagatccat 31320 atggatccta gatccagatc acggtgttag aacatggaaa aacattgcaa gattctgcta 31380 agtgaaaaaa gcatttgcaa acagtatgta cagtctatat tcagaggagg aactgctggg 31440 tcatagatga tatttcatag gtattgccaa accgttctct ggagaagtgg tatgggttta 31500 ccctgggatt cttctatgga gggaatagtt gagctcccgg gcttgctctt ctgggtgccc 31560 ctccccgctt cctatccacc acaaggagct gcaggggagc ggggcatgcc ggttccttgg 31620 ctggagaagg agtctccttg tgaggtggta gaaggagcac tgacggcctt gagcccagtt 31680 tctgcctttg tcaaatgggg ataatgaccc agccacaccc ctcccagggt tgttgtgagg 31740 ctggaaaggt ggttcccaag agggtggttc ccagaattgt tgatgagact gtttctcctg 31800 cagctgtgtg gacctggatg acaagggctg ccccgccgag cagagagcca ggttggcctg 31860 gaccccagga tgtacccttc attgcccttc actcccccac tggatgctgg gtggtcactg 31920 ctgtagggag gggaccccct gacatatgtc ccttcccacc cactcttcca ctgtggaacc 31980 tcctgtcatt ttccacttca ccaagtgaca gaggacctgc tcagatgctg aggggagggg 32040 actgcaagga aagatggcta ggaaacccag tccctccaca ccctagagta acttgatgcc 32100 ttgtgaggga cacaggcaaa gttcaattcc ttggaagtca agggagactg agaagagtac 32160 agctgcagca ctgagggagt gatgaattct taactgggga tggtgggagg cttcgagtgg 32220 gaggtggcat ttgagctagg ctttgagaga ggagcaggta ttgcacttgc atttaggtag 32280 aaagcattgg ggtgcaaggt gacactggag ggggaggcat caggaaatcc aggatgtctt 32340 caaagttctg gtgtcggggg ctgttgagta agcacaggaa taagggggtc aagttagagt 32400 cagggtgggg tctgacctgg atgccatagg acctgatccc caagccacag ggtgggactt 32460 gactgggcag tggggacctt tggaaaggac tttggggaga aaaacagact ggagtctgtc 32520 ttaggcgatc atcggtccgt gaaatgagca tgtgttacag gcttggtatg taccagaccc 32580 tgtgctaagc aagggggtat ggagaggaga gggtgacaag aatattggat caacacccgg 32640 gagctccatc tatcccagga tgcactatct tttttttatt tttttgagac ggagtctcac 32700 tctgcctgca ggctggagtg cagtggctcc atctcggttc actgcaacct ctgcctcctg 32760 ggttcaagcg cttcttgtgc ctcagcctcc caagtagctg ggattacagg cacatgccac 32820 cacacccagc taatttttgt atttttagta gagacggggt ttcaccatgt tggccaggat 32880 ggtctcgatc tcttgacctc aagatccgcc caccttggcc tcccaaagtg ctgggattac 32940 agacatgagc caccgtgccc agccagatac gctatctttt tattgagtga ttgagacagg 33000 gtcttgctct cttgtccagt cttgaatgtg gtggtgtaat cacaggctca ctgcagcctt 33060 gacctcctgg gctcaagtta cccttctgca gtagctggga ctataggagc gtgccaccac 33120 gcctgggtaa tttaaaaaat tttttttgta tagacagggt ctcactatgt tgcccgagct 33180 ggtctcaaac tcgtgggctc aagtgatcct ccagttttgg cctcccaaaa tgttgggatc 33240 acaggagtga gccaccactc ctggcgatga gccaagtctt tttttttttt tttttttttt 33300 gatatggagt cttgctctgt tgcccaggct ggagtgcaat gacacgatct tggctcactg 33360 caacctctgc ctcccaggtt caagcagttc aagcaatcct cctgtctcag ccccccagta 33420 gctgggatta caggcatgcg ctaccacgtc cggctaattt ttgtattttt agtagagatg 33480 aggttttgcc atgttggcca ggctggtctt gaactgctga cctcaggtga tccacctgcc 33540 tcggcctccc aaagtgctgg gattacaggt gtgagccatc gtgcctggcg gagccgagtc 33600 ttaaaagatg accctgtgga gaaatggtgg tccaggctga agggacagcc tatgcaaaca 33660 ctgggaggtg tggaaaatca tgacctgtgg gtggaaattt tggctagaac atcaaaatca 33720 tcaggtgtac attcctgtac ccatgcagca gtcagaatct ctgggggtgg ggccccaaaa 33780 ttgtatgcat acagactgtg tgctgatttg tgatattact taggattttt tgactttaca 33840 atggtggaaa agcaataata tacattcagt ataaaccgta ctttgaatac ccatacagcc 33900 attctgtttt tcacttttat ttttatttat ttatttattt attatttatt ttgagatgtc 33960 attttgctgt tgttacccag gctggagtgc aatggcgcag tcttggctca ccgcaacctc 34020 cacctctcag gttcaaacga ttctcctgct tcagcctcca gagtggctgg gattacaggc 34080 aggcaccacc acacccggct aattttgtat ttttagtaga gacggggttt ctccatgtta 34140 gtcaggctgg tctcgaactc gagagctcag gtgatctgcc catctcagcc tcaagccacc 34200 atgcccagcc ctactttcag tattcaataa attacatagc caggcaccgt ggctcacacc 34260 tgtaatccca gcactttagg aggccaaggt gggaggatcc tttgaggcca gaagctcgag 34320 accagcctgg gcaacatagt gagaccccat ttctacaaaa aataaaaaaa ctagctgagt 34380 gtggtggcgt gtgtctgtag tcccagctac ttgggcagct gaggtggaaa gactgcttga 34440 gcccagaggt cagggctgca gtgggccatg atctcaccac tgcactcagc ctgggcaaca 34500 cagcaaggcc ctgtctcaaa aataaataaa taaataacac aaacttattt aacagtttac 34560 tataaaatag gctttgtgtc agatgattct gcccaactgt aagctgctgg cagtgtaaat 34620 gttctgagca cgtgtaagcc aggctaggtg tcttaaatgc attttcagtt tcaacttaga 34680 attggtttat caggacgtag ccccttggtg ttgaggggca tgtgtattaa cagtctcctt 34740 agtgactttt ttttttttga gatggagtct tgcactggcc gtagtgcagt ggcacaatct 34800 cagctcactg caacctcttg tctcccgggt tcaagcgatt ctcctgcctc agtctcccaa 34860 gtagctggga ttacaggcac ccacaccacg cccagctaat ttttgtgtgt gtgtattttt 34920 agtagagacg ggggtttcac tatgttggcc aggctggtct cgaactcctg accttgtgat 34980 ctgcccacct cagactctca aagtgctagg attccaggca tgagccaccg cgcccagagt 35040 ccttagtgat ttttacacca tgaattgttg aagccctaag ccagagccaa gggcaagagt 35100 atagagaatc tggagatgcg gagagggttc tgattgccta caaggagttt ggactttatt 35160 gtggaggcag cggggagcca aggcaggttt tagagtagga gagggtccaa gcctgtgggt 35220 cacccttccg acttcccttt ccgaatgcca aacaccttca tgtccccccgt gggccccctt 35280 tgtccctccc accccaaact agccctcaat ccctgaccct ggcttccgcc cccagccctc 35340 tgacgtccat catctctgcg gtggttggca ttctgctggt cgtggtcttg ggggtggtct 35400 ttgggatcct catcaagcga cggcagcaga agatccggaa gtacacgatg cggagactgc 35460 tgcaggaaac ggaggtgagg cggggtgaag tcctcccagc ccgcgtgggg tctgcaccgg 35520 cccccggcac tgacccacca ccccctcacc ccagctggtg gagccgctga cacctagcgg 35580 agcgatgccc aaccaggcgc agatgcggat cctgaaagag acggagctga ggaaggtgaa 35640 ggtgcttgga tctggcgctt ttggcacagt ctacaaggtc agggccaggt cctggggtgg 35700 gcggccccag aggatggggg cggtgcctgg aggggtgtgg tcggcagttc tgatgggagg 35760 ggcaagagct ggaggcagtg tttgggggag ggcagttaca gcggagaagg gagcggggcc 35820 aagccctagg gtggtgaagg atgtttggag gacaagtaat gatctcctgg aaggcaggta 35880 ggatccagcc cacgctcttc tcactcatat cctcctcttt ctgcccaggg catctggatc 35940 cctgatgggg agaatgtgaa aattccagtg gccatcaaag tgttgaggga aaacacatcc 36000 cccaaagcca acaaagaaat cttagacgta agcccctcca ccctctcctg ctaggaggac 36060 aggaaggacc ccatggctgc aggtctgggc tctggtctct cttcattggg gtttggggag 36120 atatgactcc cgcaaaccta gactattttt ttggagacgg agtcttgctc tgtcacccag 36180 gctggagtgc agtggcgtta tctcggctca ctgcaacctc cacctcctgg actcaagcga 36240 ttttcatgcc tcaggctcct gagtagctgg gattacaagc gcccgctaat tttttttttt 36300 tttttgagac agagtctcgc tctgtcaccc aggctagagt gaaatggtgc ggtctcagct 36360 cagcctccca ggttaaagcg attcttctcc ctcagtctcc tgagtagctg ggattacagg 36420 cgcgagccac cacgcccggc taatttttgt atttttagta gagatgggat ttcaccatgt 36480 tggccaggtt ggtgtcaaac tcctgacctc atgatccgcc cgcctcggcc tcccaaagtg 36540 ctgggattac aggtgtgagc caccgtgccc ggcctaatct ttgtattttt agtagagaca 36600 gggtttcacc atgttgtcca ggctggtact ttgagccttc acaggctgtg ggccatggct 36660 gtggtttgtg atggttggga ggctgtgtgg tgtttggggg tgtgtggtct cccataccct 36720 ctcagcgtac ccttgtcccc aggaagcata cgtgatggct ggtgtgggct ccccatatgt 36780 ctcccgcctt ctgggcatct gcctgacatc cacggtgcag ctggtgacac agcttatgcc 36840 ctatggctgc ctcttagacc atgtccggga aaaccgcgga cgcctgggct cccaggacct 36900 gctgaactgg tgtatgcaga ttgccaaggt atgcacctgg gctctttgca ggtctctccg 36960 gagcaaaccc ctatgtccac aaggggctag gatggggact cttgctgggc atgtggccag 37020 gcccaggccc tcccagaagg tctacatggg tgcttcccat tccaggggat gagctacctg 37080 gaggatgtgc ggctcgtaca cagggacttg gccgctcgga acgtgctggt caagagtccc 37140 aaccatgtca aaattacaga cttcgggctg gctcggctgc tggacattga cgagacagag 37200 taccatgcag atgggggcaa ggttaggtga aggaccaagg agcagaggag gctgggtgga 37260 gtggtgtcta gcccatggga gaactctgag tggccacctc cccacaacac acagttggag 37320 gacttcctct tctgccctcc caggtgccca tcaagtggat ggcgctggag tccattctcc 37380 gccggcggtt cacccaccag agtgatgtgt ggagttatgg tgtgtgatgg ggggtgttgg 37440 gaggggtggg tgaggagcca tggctggagg gaggatgaga gctgggatgg ggagaattac 37500 ggggccacct cagcatgtga agggagggaa ggggctgcct gtgccccacc ttgcagggtc 37560 tgtgcacttc ccaggattag ggaaagaccg ggtagggtct gtctcctggc atcacatctc 37620 cccctgctac ctgccatgat gctagactcc tgagcagaac ctctggctca gtacactaaa 37680 gctccctctg gccctcccac tcctgaccct gtctctgcct taggtgtgac tgtgtgggag 37740 ctgatgactt ttggggccaa accttacgat gggatcccag cccgggagat ccctgacctg 37800 ctggaaaagg gggagcggct gccccagccc cccatctgca ccattgatgt ctacatgatc 37860 atggtcaaat gtgcgtggct gagctgtgct ggctgcctgg aggagggtgg gaggtcctgg 37920 gtggaggagc ccacaagggg catgaaaggg gaccaggatg tatgtagacc caggagccct 37980 agtatgttag gagcctcaaa accttcttgt atccctttta cagtcaaagt ccaaagccac 38040 tcttgaggaa cactcttgta caaaattaag ctgggcacag tggctcatgc ctgtaatccc 38100 agtacttttg gaggctgagg tgggaggatc ccttgaagcc aggagttcaa gaccagcctg 38160 ggcaacatag tgagatccta tctctacaaa aaataaaaaa attatctggg tgtggtggtg 38220 tgtgccagta gtcccagcta ctcaggagag gctgaggcag gaagatcact tgagcctagt 38280 ttaaggttgc agtaagctat gattgcacca ctgaaatcca gcctgggtga cagagcgaaa 38340 cctcatctca aaaaaataaa aaagcaaaca aaaagaaaaa aaaaattaaa agggaaacta 38400 gaagagatgc caaaggttct ggctgaagac cccagagtct ggtgctactt ctctaccacc 38460 tgagggcttt gggctgtccc ttgggactgt ctagaccaga ctggaggggg agtgggaggg 38520 gagaggcagc aagcacacag ggcctgggac tagcatgctg acctccctcc tgccccaggt 38580 tggatgattg actctgaatg tcggccaaga ttccgggagt tggtgtctga attctcccgc 38640 atggccaggg acccccagcg ctttgtggtc atccaggtac tgggcctctg tgccccatcc 38700 ctgcctgtgg ctaagagcac cctcctgcag agggtgggaa ggagagatga gtccagtatg 38760 ccaggcccct cacggaaggc tgcatgctgg gctggggagg ggccaccatc ctgcctctcc 38820 ttcctccaca gaatgaggac ttgggcccag ccagtccctt ggacagcacc ttctaccgct 38880 cactgctgga ggacgatgac atgggggacc tggtggatgc tgaggagtat ctggtacccc 38940 agcagggctt cttctgtcca gaccctgccc cgggcgctgg gggcatggtc caccacaggc 39000 accgcagctc atctaccagg gtcagtgccc tcggtcacac tgtgtggctg tctgcttacc 39060 tcccccaacc ccggtggact agggtccctt tctctgatgt tccctcaact gtcacctctc 39120 aaggaaaccc cattatccct acaaaaaatt cttactgcct tccaacccct gtgaccccat 39180 tctctccacg gtgactgtgt cataccccaa aggtgacctc tgtttttctc ctgtgaccct 39240 gtcaccttcc atggagtccc catcccagat ccgtgagtga cccccatcat gactttcttt 39300 cttgtcccca gagtggcggt ggggacctga cactagggct ggagccctct gaagaggagg 39360 cccccaggtc tccactggca ccctccgaag gggctggctc cgatgtattt gatggtgacc 39420 tgggaatggg ggcagccaag gggctgcaaa gcctccccac acatgacccc agccctctac 39480 agcggtacag tgaggacccc acagtacccc tgccctctga gactgatggc tacgttgccc 39540 ccctgacctg cagcccccag cctggtatgg agtccagtct aagcagagag actgatgggc 39600 aggggaggtg ggaccttcag cccagggtcc actgtggggg cagagggagt ggcagagaca 39660 ccggggttcc ttcccctaat gggtcacctt ctcttgacct ttcagaatat gtgaaccagc 39720 cagatgttcg gccccagccc ccttcgcccc gagagggccc tctgcctgct gcccgacctg 39780 ctggtgccac tctggaaagg cccaagactc tctccccagg gaagaatggg gtcgtcaaag 39840 acgtttttgc ctttgggggt gccgtggaga accccgagta cttgacaccc cagggaggag 39900 ctgcccctca gccccaccct cctcctgcct tcagcccagc cttcgacaac ctctattact 39960 gggaccagga cccaccagag cggggggctc cacccagcac cttcaaaggg acacctacgg 40020 cagagaaccc agagtacctg ggtctggacg tgccagtgtg aaccagaagg ccaagtccgc 40080 agaagccctg atgtgtcctc agggagcagg gaaggcctga cttctgctgg catcaagagg 40140 tgggagggcc ctccgaccac ttccagggga acctgccatg ccaggaacct gtcctaagga 40200 accttccttc ctgcttgagt tcccagatgg ctggaagggg tccagcctcg ttggaagagg 40260 aacagcactg gggagtcttt gtggattctg aggccctgcc caatgagact ctagggtcca 40320 gtggatgcca cagcccagct tggccctttc cttccagatc ctgggtactg aaagccttag 40380 ggaagctggc ctgagagggg aagcggccct aagggagtgt ctaagaacaa aagcgaccca 40440 ttcagagact gtccctgaaa cctagtactg ccccccatga ggaaggaaca gcaatggtgt 40500 cagtatccag gctttgtaca gagtgctttt ctgtttagtt tttacttttt ttgttttgtt 40560 tttttaaaga tgaaataaag acccaggggg agaatgggtg ttgtatgggg aggcaagtgt 40620 ggggggtcct tctccacacc cactttgtcc atttgcaaat atattttgga aaacagctag 40680 gcaccggcct atgtctgggg gtggctctgt gccatccctt cctgctcacc ttacactcaa 40740 ttcctctttt cctggaggga gtggctggga atcttcaga 40779 <210> 4 <211> 15761 <212> DNA <213> Homo sapiens <400> 4 gaccgggcgg gagcggggcg gggccggggc ggggcgcgga ccgtccccca ctggctgcgg 60 cgcgcggggc agcccaggct cagtgcgcgg tggcggcggc gtcgcgggca gctggcgccg 120 cgcggtcctg ctctgccggt cgcacggacg caccggcggg ccgccggccg gagggacggg 180 gcgggagctg ggcccgcgga cagcgagccg gagcgggagc cgcgcgtagc gagccgggct 240 ccggcgctcg ccaggtccgt gcttggggcc gggcaggctc gcggaggggt ccaacggtgc 300 tcgcggaggg gtcggggcgc ggctgtcgcg gaaccacaga ggtccctgca gcgggccggg 360 ccggggcgcg ggcttcccgc tccggaaagt ttgccgccgc cgccgccctg ggagggcttt 420 gcagcagcca gggagggaag ggggaggagg gagggaccgc ggcggggagg aggcggccgg 480 cgccaggcgg cccgggagcc ctgggcggcg gcggcggcgg gcggggcggc tgggggtcgg 540 aggggtcggg acgcaggagc cggccaccgc cgctttcgtc cctgtccgcc cctctaacga 600 gctgccttcc tcctcctgta gtctcccgag cggcgcccgc ctcccgccgg tgcccgcgcc 660 gggccgtggg gggcagcatg cccgcgcgcg ctgcctgagg acgccgcggc ccccgccccc 720 gccatgggcg cccctgcctg cgccctcgcg ctctgcgtgg ccgtggccat cgtggccggc 780 gcctcctcgg agtccttggg gacggagcag cgcgtcgtgg ggcgagcggc aggtaagaag 840 ggacccacta ggcacgggag aggccggccc gtgcgggcag aggcgttggg gacgggaacc 900 ggccccgggt cggaggggcc gccgggtgtg agtgacgccc cggggttaga gcccggattc 960 cgctgcctcc ttgccggaga gcgcggccag agctagcgcg gcgacttgtg gtgcgcccgg 1020 agccgcagct accctccaag tgcgaggcca ccacggggag ccaggctggg ggttggcgtc 1080 cgcagccccg atcccctgcg actccctagc cctggcctgt cgggagggcg cggggggccc 1140 catttccacg attcccgctg ttgttattcg ggttctgcgc agacggaaag ttcccattgt 1200 tggcgtcccc ctccccccggg ccccagtttg tggccagctt cggccaaggc gagagaccgg 1260 acttctaagg gtgggtgtgc gcgtcagcga agcccggccc ctgcccgccc gaagaggcag 1320 cagcctccag cgtccccgct gccgaccctg cccctgcctg ggggccgagg gcgcttcccc 1380 gtgggtgcgc gccgagctcc aggcaagcga ggggcgcgtg tcccagcgtc gcgggcccta 1440 gactgggctg gcggtccagg tcccgcggga cgtcgagggt ctgaagggag gtcccaaggg 1500 gcgaggggag gggaaggggc gcccggccgg acctgcacac gcgccgcggt tcctcgtggg 1560 ccgggccgag agctccggtg ccgccgccgc gtacacccgc agccggctcc ggacgggcga 1620 ggggggcgcg cacagctcag cccggcggcc gcgcggaggg aggccttggc ccggtgagct 1680 cgcgccccac ccgggccgag gcccgaacag ccgcttcttt gtacctcgac gcggccacag 1740 accgcgcatt gatggcggct cggcggctcg cggggaggtg tgagcgaccg cgggcgcggc 1800 gggccgggga gggcgcctgg agggccgagg cagatggcgt ccgccccgcc cgcgcccccg 1860 cgcccctttc tccgtcggcg gctgcagcct cccggaacaa tgtcattttt tttatgaatg 1920 aaagtggccc ggcgcttgaa tgtgcgtgtc attcagcggc gtgacagggg ccgtcgggag 1980 gtcagcgcgc gcttttagcg tctgctcggg cggccccgct tccaggggtg ccggaggggc 2040 ggccgcgggg ggagcttggc tttcgcattc tcattcagat aaagatatta ctccctacgg 2100 cccgggaatg tcagccagcc ccggggaagg gcggcggcca ggctgcggag cctctcctgg 2160 accccctgcg ggcgcgcggg gcctccccca gtcgctcctg gaacgccccg cccacccctc 2220 ccccggggcg gcgcccccgc ccgcactgga gctggtgaaa caggtagtga gttgatcggt 2280 caataaactt aatccggttc cttaacaaga tgggccgggc agtaaaaata caaagacctc 2340 gtgaaatgga ctgaggtcta ggctggcgct tgcccgggaa cataaattat ggagccttgg 2400 ctcgcagggg tcaagggcgg tgggaaaggt tttggccact ggactgccct ggccacccca 2460 ggccctgcca ggacagcccc catctcccca gggggccgta ttcctggttg ggacctggag 2520 tgacccccca gggtgcaggg aggtacacaa ggtcggctct cccacagtcc caccccaccc 2580 agcaggggtc tgggggtgca gggcctttcc cgaaggtgct ggctgcaacc tccccccactc 2640 ctcctctgca gggctggact ttgagccgcg tgggcctctg ggtggttcat taacctgggc 2700 tgagcctggc ctccaggtcc ttgtgtgagc ctaggaaccc cttgttaccc accccccagc 2760 tccccagccc tcaggtctca cttggggcta gatctggggc tgtggcaccc cttgttacag 2820 ctgagcttga gtgggagccc aggggcttgg ggtctcctgg aggacgggga tctaaagtca 2880 cctcatctag ggaggcatgc agccctcacc tgagtgattc aggagtgaat gagccaggag 2940 tggagccacc tttggtgggg taggggtcag cctggacctc taggctgcca gctcaggctc 3000 gggtgccctc ttcgaacctc agtttcctta cctgtccaag agaaccgata atggcaggct 3060 gtttgaagga ttaggccaga taaccctggc aagccctctt tagcctgccc agcctccaga 3120 tccctttttt ccggacttta ttgtgaaact ccaggtgggg agacagggag gctggacttt 3180 tgggggcccc ctcctcttag gctattttat agctcctacc tggcaatacc tcctgtaccc 3240 cagagagctg cagagaactt catgtgcatc cgaaaccaga atgtgttgtt tcctgacccc 3300 aggccctcat ctcaccccaa aacccaaata aacccctggg gcagccagct ccggaagcga 3360 gtctggattt gatccttgtt ctctggggtc aacccgaggg gcttatgatg gagcaaggct 3420 cccccatcct ctcagccatg ctccctcaca tgcactgggc ctccactgca gagacccaga 3480 gcctggagaa aggttcccca ggccagagtt tggccgtccc cagcaccctg cctaatggac 3540 atcagtcttg gggccagaga cccagggcag ggagcgcctc tcacccctac cctcactcct 3600 gcagccattt cagggcctgg tgccctccct gagctcctgg gcctgtgggg tgggattttt 3660 actttgtgcc acagtggggg aaactgaggt acaggaccag tgagtggcag agttgtggag 3720 actctgggac acagcagagg gctgtcgttg gcatgtggag cccaagttga ggtcggcact 3780 gtgtggggtt ggggcgccgg caggagcacg tgttgtggga tccatagaag ggtgggaggt 3840 gggacgcgtt gcctcctacc ccgccttggg tacagcagga gttttgtctc caacgtgttt 3900 gggcaccagt gtctgtgtgg tgtcagtggg gcctcccttt tgtggatcaa gaaagaaaga 3960 acccttccta gggctgctgg ggggctatag ctctccccat gcctggcagc tgggtggggt 4020 atgggggctc cacccaactg ctgacttccc agtgggagtc agaccctgaa cttatagcac 4080 ccactcatgc cccgtgtcac actgtccttc acctggtgct cgccacccag cccctgctgg 4140 ggtaccctgg cctctgctgg cacctagcag gcaggcagtg gggggggcag tcagggctgc 4200 accctcccca ccacacacgg gcagatggcc actggtgtgg ctggcctggg gctgctgtgt 4260 cccccgtccc cccgtgctgg accaggctga agcaaatact tgtgtggatg gcttgacctg 4320 ttgtcgccac tcagaccaaa ccggaaccaa ccggctgttg cccttgggcc agggcctgca 4380 gctgaggctg ccataaccag cctgttctcg gccttctggg gggcctcgag cagctcccag 4440 ctctgggtgg tccccacaag acactggcca ggaccggagg gctggaggtc aggccaggag 4500 cccccctgac tgcggggtcc ctacaggggc agtccttgag ctgtgggtcc cggtggggcg 4560 agggctcctt cggatgcttc aggggatgag tgtgggccct tctggctggc agggtcaccc 4620 tgggcactag gcgtgtgtgg ctggatcagg tgggttgggc agaagagggc ctggccgggc 4680 agccagggac tggtgtggcc agagtgggca gctgggcccc cgaatctagg ccacgcgtct 4740 gcagaatgac aagtgatggc gcaacccgcc cagctgggtc tgaagaagga ggctgcctgg 4800 gggaccaccc acccccgtcc cggccccaag cccgggacgc ctgcctgcat gcattgtctg 4860 gccctggcag ggaagcctag gggcgattgt ccccccagcc ctgcccatgg tgtgtccttg 4920 ggtcacaggc tttggtggct ctggggagct gggcagctac tggggaggga cccaggggcc 4980 acctgcacat ctgcccctgt gggtgggccc ccaccccagc ttctcagccc ccagggaggg 5040 gccagggctg ctgacctgcc ctggctctca cagcttcctg cccccagcct ggtcgtcctc 5100 tgtgaggggg ccccagtccc cctgcaggca gcaggactcc accccccggc ccccttgagg 5160 gcccgcctgg gcctccccac tccccggcct gtgagaccca cttggccgga cccagcgccg 5220 tgtttgtact ttgctcttct cggtatgttt tccgtcatga ccgccgtgtg gagcttccat 5280 aggagctgca ggatacagaa ccttgcccac cccaaggagc ccccaccccc gccccggccc 5340 cctcgcgctg ctccggcctg tgctctgacc ggtgaacccg cgcatcgccc cccagaccgt 5400 ccacacggcc acgtgaccct gcacctcctt ccttctcgcc tgttctgttc cctggctgtc 5460 catctgaact gcttttcagg ctcatatggg gtgcgggggc tactgaggac ggacccctcc 5520 tggggtgaat ctgcaccacg agggggctgg ctggccaacc ctggcacccc ctctgagctc 5580 catttcagtc agaggccagc aaagggcagc ctgtcccctt tgcccgcagc acctgcccgt 5640 cgtggtgccg cctgtgagac aagcatggat tttatgtttc caagcaattg aacaaattaa 5700 aagaacgaag agtcacattt tgtgacactt tgagatttga attctccgtg tccatgagtg 5760 aagcatcatg gggccactgc tgtggggttg gctgcaggtt gtgtggggaa ggcggctgtc 5820 acaccgaggc agaccggagt ccttgggaca gactggttgg caaagctgaa gatagagacc 5880 tttggccctt ttgggacaca gtttccagcc cctggtctgg tgggaccctg gatctgggtc 5940 agagccttcc tcactcaggg ccgccgaggc ttccactgct gtgtctgtaa acggtgccgg 6000 gtttgggggt gcctgcctca tggttgccca tcttccccac agaagtcccg ggcccagagc 6060 ccggccagca ggagcagttg gtcttcggca gcggggatgc tgtggagctg agctgtcccc 6120 cgcccggggg tggtcccatg gggcccactg tctgggtcaa ggatggcaca gggctggtgc 6180 cctcggagcg tgtcctggtg gggccccagc ggctgcaggt gctgaatgcc tcccacgagg 6240 actccggggc ctacagctgc cggcagcggc tcacgcagcg cgtactgtgc cacttcagtg 6300 tgcgggtgac aggtgagctc tggggccacg ccagctacag aaaggagccg agtgccgggc 6360 tccctgagtc cctgcgtggg tcaggagcgg ctgggggtct ctctggtcat tggtggagag 6420 gagggcaccc ccaggaagtg ctgcccaaat gggggaccct gccccatctg ggaggggcac 6480 ctgggggcct cctggggcag gttgggcatt ggttgcggcc atctctgcct tgcagacgct 6540 ccatcctcgg gagatgacga agacggggag gacgaggctg aggacacagg tgtggacaca 6600 ggtaggagca gggtccaggg ttcaggccag ccggggtggg gcccgctgcc accgccaagc 6660 cctgcccttc acaggcagct gagggactaa ggccccggaa caacctccct ggggtcaccc 6720 cgaaggtctg gtcccctcag gatacaggag gggctgggtc actgacatgg ctctagatgc 6780 cccaccctgg tggcagggct ggggtgcaag gggacaccgt gttgctgatg gggagactga 6840 ggcacagggc cctgggggtt ccaggagcag gaggaggcca gggctggcct gtggggctct 6900 ggtgttggct ataggtgagg tggaccccgc agacattagc gcagcagggc agggcactca 6960 ggtggctgcc gtggggtgga tggacccggg gtgagggcgc cggggcacct gccacaacca 7020 gtggcgggca gggtggctgg caggagggtg gctggtgggt gggctgcggc tgtgagagag 7080 cagtcgggga cgatgcctgg cgtcccggcc tggaacggtg gcaggtggac tttgccaagt 7140 tgtagggtgg ggaggtgggg cttctggttt tggagggagc tctgagggga gtgcgtgcag 7200 gtgagggtca tcgtggcaca gacatggggg gcagttacga cttgcggact gatggtgtgt 7260 gcgctgggtc cctgggccag tggggtaagc aggtgaggaa gggaggctga gtccatgaga 7320 gaaacagctg ggggaactca ccctgggggt ctccaggagg cctgggaggg agctcagcac 7380 cgtggggtgc ctctttccag cctgtgtcca cactgctgct tgctgggcct cagtgcccct 7440 gatgggcgtg tgcctggagg gggctggcag tgagctcact gaggggaggg ctgcttccct 7500 cctggggaat gccagcccat ccttgcctgg agtcccggca ggaaggcagc accagccctg 7560 aggaaggaga aaaaccagtt gggctgtgag aggggtggtg ggagccctgg acatcgagat 7620 gggaggaggc agggcctcca gggtgccacc gtctctgggt gcccgccaga cttggagctc 7680 tgcagagggt ggtgtagggt cttgatttcc gtgggcccat gctgcccagc tgcctccaag 7740 gctcctggct ctgcaggcga ctgggctcct ctcctggtaa actgctccca ggtcctggct 7800 tgtccactag atgggcctgc cccctgggtc ttcagtctcc ccgttggtgg gcctggccct 7860 ggcacgcctc tctgggcagg tgggctcccc tggacaatgc cctgtgccct gtgacttcac 7920 aggtccgggc agagcaccct ggaggggagg ggaggggaca cacggcccag ctctgagaaa 7980 gccccgggga ggggacaaga tgtggaggct cctgggaacc tcatcccgcc ctcttcctac 8040 acaggacggg aaactgaggc tggggatggg caggggcagc tctgggaagg gggttgttca 8100 gaggggcctc tgctcccact cgggtcatgg ccttcacacg cacctcggcc cgcaggggcc 8160 ccttactgga cacggcccga gcggatggac aagaagctgc tggccgtgcc ggccgccaac 8220 accgtccgct tccgctgccc agccgctggc aaccccactc cctccatctc ctggctgaag 8280 aacggcaggg agttccgcgg cgagcaccgc attggaggca tcaaggtggg cgcggcgggg 8340 tggctctggg cctggcaggc gcggtggttg ctgcctccgc tcactcaccc gcccgcgtcc 8400 cggtgcagct gcggcatcag cagtggagcc tggtcatgga aagcgtggtg ccctcggacc 8460 gcggcaacta cacctgcgtc gtggagaaca agtttggcag catccggcag acgtacacgc 8520 tggacgtgct gggtgagggc cctggggcgg cgcgggggtg ggggcggcag tggcggtggt 8580 ggtgagggag ggggtggccc ctgagcgtca tctgccccca cagagcgctc cccgcaccgg 8640 cccatcctgc aggcggggct gccggccaac cagacggcgg tgctgggcag cgacgtggag 8700 ttccactgca aggtgtacag tgacgcacag ccccacatcc agtggctcaa gcacgtggag 8760 gtgaatggca gcaaggtggg cccggacggc acaccctacg ttaccgtgct caaggtgggc 8820 caccgtgtgc acgtgggtgc cgccgctggg gctcctgggc tggccccaag ggtgcccctt 8880 ggctgcgggt tgcgtgagga tttgggtcta ggggttggag cttcgggggc agaagctgtg 8940 ggggtgcttg tggggccaag tctcagccac cccacacctc agggccatag gcagctgcgt 9000 tgggacccgt ttccgtgtct gcagagggcc agcctcagcc actgaagtcc ctgacatgga 9060 gctgcccacg ggcttcttgg gggtgggtgc ggcttgggca gcagtggtgc cccaggacag 9120 gagggcagtg tggccaagcc ctccaggccc cctctgggcc tcagaggcgg tggctgagcc 9180 ccgacctggc cgattggctc tcgtcagctg tgtgcagtgg ggcccgagct cactgtctgc 9240 ccgcctcctg aagcccttag ctttgttccc atggctgccg ggtgggggcc actgaattgg 9300 gacggttgcg acactcaaag cccaaagaga aacatctgtt cagagagaag acggtctctt 9360 gggggcgggg agcaggcgca gggcgagggt gggatccaga ccccgcccag agaggccgcc 9420 tcgggccctg tccagggtgc aggttctgca agagcccggg ggagggcagg ccagtgacca 9480 gaggttgtct gagggtctgg gctgggttgt tggggtggag gcagagacgt gcatcctgtg 9540 aaaccacagc caccgtgaag tgcctccacg cctcctccag gcagcctttg gggctgacgc 9600 agcccagcct cgatctgtac cttgggggtc tcccacatcc tgcctcgtgc ccggcggggc 9660 tgcctcgggg gcgtgcctga gccgggtctc ttgtccccgc agtcctggat cagtgagagt 9720 gtggaggccg acgtgcgcct ccgcctggcc aatgtgtcgg agcgggacgg gggcgagtac 9780 ctctgtcgag ccaccaattt cataggcgtg gccgagaagg ccttttggct gagcgttcac 9840 gggccccgag caggtaacga ctctgtccca tgccggccgg cacaagagct ccagctccaa 9900 ggccctggcc gcgcgccctg cacgccccgc acgcccagcc ctgctcgctc ccgccccggc 9960 tcgcgctcca ctcggggccg cctcggcaag gctggcagct ccagcctcca cggtgaccgc 10020 ccgcttcgag ccctgtggcc tgcgccgacc cttcccgcac gcctgcgacc cccacaggag 10080 gtgcccggtg cccaccgggc cggctccgtg ccgtctgtga gcaccccttt gcgcctctct 10140 ccacccctgc ccgctgcctg ctcgcttccg cagcctgtgt gtccctgtgt ccatcctcca 10200 cctgcacccg cccggctctg cgctaacccg catgctgcct gcccgcctgc cgctcacctg 10260 ggacagagga ctcgccggtg gaggggcctg gcttcgggct cagtaccggt gtaccaggcg 10320 gagggccctc agccgcgtgg cggtgaccaa gttggcggtg gctgaggagt tggtggtggc 10380 ggcgttttcc ttgcagcggc tggatcctgc cgtgtggact ctgtgcggtg cccgcagggc 10440 ggtgctggcg ctcgcctatc gctctgctct ctctttgtag acggcgggcg ctaacaccac 10500 cgacaaggag ctagaggttc tctccttgca caacgtcacc tttgaggacg ccggggagta 10560 cacctgcctg gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct 10620 gccaggtacc ggcttctgct gctgctgctg ctccgcactg tctgggggac gctggctcgg 10680 gacacgccaa agctgccagg acggacggga atcctgtgac ttacggccgt cccgcttctt 10740 gagccctcac tcctggccct gtgcccagtg tggggacaaa gttggcctgg cccggtcctg 10800 gtcccagagg ggccccctca gccccctcga gcccacttcc catctgggtc cccaaaggcc 10860 tctcctgtgg ctctggtgtc tcccgggcgc ctggtggcgg tgtgggactg gctggctctg 10920 ctgggctcct tctctccagg gtctggccct ctagactcac tggcgttact gactgcgaga 10980 ccctccagac aaggcgcgtg ctgaggttct gagccccctt ccgctcccag tggtgcctgc 11040 ggctctgggc caggggcatc catgggagcc ccgtgggggg gggggccagg ccaggcctca 11100 acgcccatgt ctttgcagcc gaggaggagc tggtggaggc tgacgaggcg ggcagtgtgt 11160 atgcaggcat cctcagctac ggggtgggct tcttcctgtt catcctggtg gtggcggctg 11220 tgacgctctg ccgcctgcgc agccccccca agaaaggcct gggctccccc accgtgcaca 11280 agatctcccg cttcccgctc aagcgacagg taacagaaag tagataccag gttctgagct 11340 gcctgcccgc caggcctcct ggagccccac ctcggcccac gctggtcctg ggctgtgtga 11400 gccctctctg cagccaggcg ggctcccctc tcctcgtctc tgctcaccat gtagagccta 11460 gggtactttg gggcacgaaa cattctaaaa atcttcattc aatgctggtg gaagtcagaa 11520 cgccccccct tctggcccag cactgacccc cggctgtacc tccacgccct gtcgccccacg 11580 cggcgccaac ctgcccctgc tgacccaagc aggtgtccct ggagtccaac gcgtccatga 11640 gctccaacac accactggtg cgcatcgcaa ggctgtcctc aggggagggc cccacgctgg 11700 ccaatgtctc cgagctcgag ctgcctgccg accccaaatg ggagctgtct cgggcccggt 11760 cagtggtgct gagggccagc gttggctgta gggggcttgg tggtgggggt gaaacagcca 11820 ccagtcagag gcccggctgg gtttaggggc cgtcagggat gtggcggatg ttgggtgtgg 11880 ctggggttct gtggagatgc tcctgggacg ggtgtatggc agggactgcc cctctcaagg 11940 tgccctgtct ggaggggcag caagggcggg aggctgtggg tgacactctt cgtccttacg 12000 agcaggctgt agggggagca tggagggctt cctggaggtg gtggctctgg gcctcaaggg 12060 ctgggccagg ctggggtggg gaccgtggtg ggctgagagt gggcgagttt gcacactcat 12120 ggtccctctg cctccactgc caggctgacc ctgggcaagc cccttgggga gggctgcttc 12180 ggccaggtgg tcatggcgga ggccatcggc attgacaagg accgggccgc caagcctgtc 12240 accgtagccg tgaagatgct gaaaggtgag gagggggcgg ccaggggtgc agagcagggc 12300 tgggggcgcc gccgccgcct gacacaggcc ccccgctccg tgcacagacg atgccactga 12360 caaggacctg tcggacctgg tgtctgagat ggagatgatg aagatgatcg ggaaacacaa 12420 aaacatcatc aacctgctgg gcgcctgcac gcagggcggt aggtgcggta gcggcggtgg 12480 tgccggctgg gcggccctcc tgggcctggc agcccgtctg aggagcccgt gtccccaggg 12540 cccctgtacg tgctggtgga gtacgcggcc aagggtaacc tgcgggagtt tctgcgggcg 12600 cggcggcccc cgggcctgga ctactccttc gacacctgca agccgcccga ggagcagctc 12660 accttcaagg acctggtgtc ctgtgcctac caggtggccc ggggcatgga gtacttggcc 12720 tcccagaagg tgggcagggc ggcaggtgtg ggtggagtag gctgggccct gccctgagat 12780 gctgggagca gcggggagag gtggagaggc ttcagccctg cctccccaccc cttccccagt 12840 gcatccacag ggacctggct gcccgcaatg tgctggtgac cgaggacaac gtgatgaaga 12900 tcgcagactt cgggctggcc cgggacgtgc acaacctcga ctactacaag aagacgacca 12960 acgtgagccc ggccctgggg tgcgggggtg ggggtcatgc cagtaggacg cctggcgcca 13020 acaccgcctt cccacaccct cccagggccg gctgcccgtg aagtggatgg cgcctgaggc 13080 cttgtttgac cgagtctaca ctcaccagag tgacgtgtac gtgtcctgca gagctcaggc 13140 ttcaggggtg gaggcgggaa ctgggcagag ccaggacccc agctgcagtc cccaggcctg 13200 tgccctggag ctcctgggtg tggtttctac ccctccctgg gggcagcagc gcagccctgg 13260 cctattcccc tggtgcccgc ccaggtgtct gtcctgggag tctcaggaca gcctgacctc 13320 accttcccct gcagctggtc ctttggggtc ctgctctggg agatcttcac gctggggggc 13380 tccccgtacc ccggcatccc tgtggaggag ctcttcaagc tgctgaagga gggccaccgc 13440 atggacaagc ccgccaactg cacacacgac ctgtgagtgg catccctggc cctccactgg 13500 gtcctcaggg gtgggggtcc ctccggggct gggcggggga gggactggca gcccttcagg 13560 ctgttcccga ataaggcggg aagcggcggg gctcactcct gagcgccctg cccgcaggta 13620 catgatcatg cgggagtgct ggcatgccgc gccctcccag aggcccacct tcaagcagct 13680 ggtggaggac ctggaccgtg tccttaccgt gacgtccacc gacgtgagtg ctggctctgg 13740 cctggtgcca cccgcctatg cccctccccc tgccgtcccc ggccatcctg ccccccagag 13800 tgctgaggtg tggggcgggc cttctggggc acagcctggg cacagaggtg gctgtgcgaa 13860 gaggggctcg gtggcacagc gctcaccccg cctcccgcca gcaggagtac ctggacctgt 13920 cggcgccttt cgagcagtac tccccgggtg gccaggacac ccccagctcc agctcctcag 13980 gggacgactc cgtgtttgcc cacgacctgc tgcccccggc cccacccagc agtgggggct 14040 cgcggacgtg aagggccact ggtccccaac aatgtgaggg gtccctagca gccccaccctg 14100 ctgctggtgc acagccactc cccggcatga gactcagtgc agatggagag acagctacac 14160 agagctttgg tctgtgtgtg tgtgtgtgcg tgtgtgtgtg tgtgtgtgca catccgcgtg 14220 tgcctgtgtg cgtgcgcatc ttgcctccag gtgcagaggt accctgggtg tccccgctgc 14280 tgtgcaacgg tctcctgact ggtgctgcag caccgagggg cctttgttct ggggggaccc 14340 agtgcagaat gtaagtgggc ccacccggtg ggacccccgt ggggcaggga gctgggcccg 14400 acatggctcc ggcctctgcc tttgcaccac gggacatcac agggtgggcc tcggcccctc 14460 ccacacccaa agctgagcct gcagggaagc cccacatgtc cagcaccttg tgcctggggt 14520 gttagtggca ccgcctcccc acctccaggc tttcccactt cccaccctgc ccctcagaga 14580 ctgaaattac gggtacctga agatgggagc ctttaccttt tatgcaaaag gtttattccg 14640 gaaactagtg tacatttcta taaatagatg ctgtgtatat ggtatatata catatatata 14700 tataacatat atggaagagg aaaaggctgg tacaacggag gcctgcgacc ctgggggcac 14760 aggaggcagg catggccctg ggcggggcgt gggggggcgt ggagggaggc cccagggggt 14820 ctcacccatg caagcagagg accagggcct tttctggcac cgcagttttg ttttaaaact 14880 ggacctgtat atttgtaaag ctatttatgg gcccctggca ctcttgttcc cacaccccaa 14940 cacttccagc atttagctgg ccacatggcg gagagtttta atttttaact tattgacaac 15000 cgagaaggtt tatcccgccg atagagggac ggccaagaat gtacgtccag cctgccccgg 15060 agctggagga tcccctccaa gcctaaaagg ttgttaatag ttggaggtga ttccagtgaa 15120 gatattttat ttcctttgtc ctttttcagg agaattagat ttctatagga tttttcttta 15180 ggagatttat tttttggact tcaaagcaag ctggtatttt catacaaatt cttctaattg 15240 ctgtgtgtcc caggcaggga gacggtttcc agggaggggc cggccctgtg tgcaggttcc 15300 gatgttatta gatgttacaa gtttatatat atctatatat ataatttatt gagtttttac 15360 aagatgtatt tgttgtagac ttaacacttc tacgcaatg cttctagagt tttatagcct 15420 ggactgctac ctttcaaagc ttggagggaa gccgtgaatt cagttggttc gttctgtact 15480 gttactgggc cctgagtctg ggcagctgtc ccttgcttgc ctgcagggcc atggctcagg 15540 gtggtctctt cttggggccc agtgcatggt ggccagaggt gtcacccaaa ccggcaggtg 15600 cgattttgtt aacccagcga cgaactttcc gaaaaataaa gacacctggt tgctaacctg 15660 gccctgtgct ttctgtctcc agttctggga taggggaggg aggggtcact ttgccaggtg 15720 gtcccagttg cgcgggatgg atgctggcag cagcaccgaa a 15761 <210> 5 <211> 7292 <212> DNA <213> Homo sapiens <400> 5 tgaaacctcg tctctacaaa aaaatacaaa aaattagcca ggcatggtgg tgcacaccta 60 tagtcccagc cacttaggag gctgaggtgg gaagatcact tgaggccagg agatggaggc 120 tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag tgacagagca agaccctatc 180 tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag acgccaactc tctctagctc 240 gctagtgggt tgcaggaggt gcttacgcat gtttgtttct ttgctgccgt cttccagttg 300 ctttatctgt tcacttgtgc cctgactttc aactctgtct ccttcctctt cctacagtac 360 tcccctgccc tcaacaagat gttttgccaa ctggccaaga cctgccctgt gcagctgtgg 420 gttgattcca cacccccgcc cggcacccgc gtccgcgcca tggccatcta caagcagtca 480 cagcacatga cggaggttgt gaggcgctgc ccccaccatg agcgctgctc agatagcgat 540 ggtgagcagc tggggctgga gagacgacag ggctggttgc ccagggtccc caggcctctg 600 attcctcact gattgctctt aggtctggcc cctcctcagc atcttatccg agtggaagga 660 aatttgcgtg tggagtattt ggatgacaga aacacttttc gacatagtgt ggtggtgccc 720 tatgagccgc ctgaggtctg gtttgcaact ggggtctctg ggaggagggg ttaagggtgg 780 ttgtcagtgg ccctccaggt gagcagtagg ggggctttct cctgctgctt atttgacctc 840 cctataaccc catgagatgt gcaaagtaaa tgggtttaac tattgcacag ttgaaaaaac 900 tgaagcttac agaggctaag ggcctcccct gcttggctgg gcgcagtggc tcatgcctgt 960 aatcccagca ctttgggagg ccaaggcagg cggatcacga ggttgggaga tcgagaccat 1020 cctggctaac ggtgaaaccc cgtctctact gaaaaataca aaaaaaaatt agccgggcgt 1080 ggtgctgggc acctgtagtc ccagctactc gggaggctga ggaaggagaa tggcgtgaac 1140 ctgggcggtg gagcttgcag tgagctgaga tcacgccact gcactccagc ctgggcgaca 1200 gagcgagatt ccatctcaaa aaaaaaaaaa aaaggcctcc cctgcttgcc acaggtctcc 1260 ccaaggcgca ctggcctcat cttgggcctg tgttatctcc taggttggct ctgactgtac 1320 caccatccac tacaactaca tgtgtaacag ttcctgcatg ggcggcatga accggaggcc 1380 catcctcacc atcatcacac tggaagactc caggtcagga gccacttgcc accctgcaca 1440 ctggcctgct gtgccccagc ctctgcttgc ctctgacccc tgggcccacc tcttaccgat 1500 ttcttccata ctactaccca tccacctctc atcacatccc cggcggggaa tctccttact 1560 gctcccactc agttttcttt tctctggctt tgggacctct taacctgtgg cttctcctcc 1620 acctacctgg agctggagct taggctccag aaaggacaag ggtggttggg agtagatgga 1680 gcctggtttt ttaaatggga caggtaggac ctgatttcct tactgcctct tgcttctctt 1740 ttcctatcct gagtagtggt aatctactgg gacggaacag ctttgaggtg cgtgtttgtg 1800 cctgtcctgg gagagaccgg cgcacagagg aagagaatct ccgcaagaaa ggggagcctc 1860 accacgagct gcccccaggg agcactaagc gaggtaagca agcaggacaa gaagcggtgg 1920 aggagaccaa gggtgcagtt atgcctcaga ttcactttta tcacctttcc ttgcctcttt 1980 cctagcactg cccaacaaca ccagctcctc tccccagcca aagaagaaac cactggatgg 2040 agaatatttc acccttcagg tactaagtct tgggacctct tatcaagtgg aaagtttcca 2100 gtctaacact caaaatgccg ttttcttctt gactgtttta cctgcaattg gggcatttgc 2160 catcaggggg cagtgatgcc tcaaagacaa tggctcctgg ttgtagctaa ctaacttcag 2220 aacaccaact tataccataa tatatatttt aaaggaccag accagctttc aaaaagaaaa 2280 ttgttaaaga gagcatgaaa atggttctat gactttgcct gatacagatg ctacttgact 2340 tacgatggtg ttacttcctg ataaactcgt cgtaagttga aaatattgta agttgaaaat 2400 ggatttaata cacctaatct aaggaacatc atagcttagc ctagcctgct tttttttttt 2460 ttttttttgg agacagagtc tcactctgtc acccaggctg gagtgcagtg gcgggatctc 2520 ggctcactgc aacctccgcc ttctgggttc aagcgattct cctgcctcag cccactgagt 2580 agctgggatt acaggcacct gccccgacgc ccagctaatt ttttgttatt tatttatttt 2640 tttttttagt agagatgagg tttcaccatg ttggccaggc tagtctcgaa ctcctgacct 2700 tgtgatctgc ctgccttggc ctcccaaagt gctgggatta caggcgtgag ccaccgcacc 2760 cggcctgcct agcctacttt tattttattt ttaatggaga cagcatcttg ctctgttgcc 2820 caggctggat tacagtgatg tgatcatagc tcattatacc ctcctgggct caagcaatcc 2880 ccctaactct gcctccccag tagctaggac cacaggcata caccaccata cccagctaat 2940 ttttaaaatt ttttgtagat agatagagtc tcactatgtt gcccaggctg gtctctagcc 3000 tacttttttg agacaaggtc ttgctctgtc acccaggctg gatagagtgc agtagtgcag 3060 tcacagctca ctgcagcctc cacctcccag gctccatcca tcctcccagc tcagcctccc 3120 aagttgcttc aactacaggc ctgcaccacc atgcctggct aatttttatt tatttatttt 3180 tattttattt tattttattt ttttgagact cagtctcact ctgtcgccca ggctggagtg 3240 cagtggcatg atctcggctc actgcaacct ctgcctcctg ggttcaagtg attctcctgc 3300 ctcagcctcc cgaatagcta ggactacaag cgcctgctac cacgcccagc taatttttgt 3360 atttttagta gagacagggt ttcaccatgt tggccaggct ggtctcgaac ttctgaccat 3420 gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac aggtgtgagc caccacgccc 3480 ggctaatttt tatttattta tttaaagaca gagtctcact ctgtcactca ggctagagtg 3540 cagtggcacc atctcagctc actgcagcct tgacctccct gggctccggt gatttcaccc 3600 tcccaagtag ctaggactac aggcacatgc cacgacaccc agctaatttt ttattttctg 3660 tgaagtcaag gtcttgctac gttgcccatg ctggtatcaa acccctgggc tcaatcaatc 3720 cttccacctc agcctcccca agtattgggg ttacaggcat gagctaccac actcagccct 3780 agcctacttg aaacgtgttc agagcattta agttacccta cagttgggca aagtcatcta 3840 acacaaagcc ctttttatag taataaaatg ttgtatatct catgtgattt attgaatatt 3900 gttactgaaa gtgagaaaca gcatggttgc atgaaaggag gcacagtcga gccaggcaca 3960 gcctgggcgc agagcgagac tcaaaaaaag aaaaggccag gcgcactggc tcacgcctgt 4020 aatcccagca tttcgggagg ctgaggcggg tggatcacct gaggtcagga gttcaagacc 4080 agcctagcca acatggtgaa accccgtctc tactaaaata caaaaattaa ccgggcgtga 4140 tggcaggtgc ctgtaatccc agctacttgg gaggctgagg caggagaatc gcttgaacca 4200 ggaggcggag gttgcaggga gccaagatgg cgccactgca ctccagcctg ggcgatagag 4260 tgagactccg tctcagaaaa aaaagaaaag aaacgaggca cagtcgcatg cacatgtagt 4320 cccagttact tgagaggcta aggcaggagg atctcttgag cccaagagtt tgagtccagc 4380 ctgaacaaca tagcaagaca tcatctctaa aatttaaaaa agggccgggc acagtggctc 4440 acacctgtaa tcccagcact ttgggaggtg gaggtgggta gatcacctga cgtcaggagt 4500 tggaaaccag cctggctaac atggtgaagc cccatctcta ctaaaaacac aaaaattagc 4560 caggtgtggt agcacacgcc tgtagtccca gctactcggg aggctgaggc acaagaatca 4620 cttgaacccc agaggcggag attgcaatca gccaagattg caccattgca ctcccgcctg 4680 ggcaacagag tgagacccca tctcaaaata aataaataaa tatttttaaa agtcagctgt 4740 ataggtactt gaagtgcagt ttctactaaa tgcatgttgc ttttgtaccg tcataaagtc 4800 aaacaattgt aacttgaacc atcttttaac tcaggtactg tgtatatact tacttctccc 4860 cctcctctgt tgctgcagat ccgtgggcgt gagcgcttcg agatgttccg agagctgaat 4920 gaggccttgg aactcaagga tgcccaggct gggaaggagc caggggggag cagggctcac 4980 tccaggtgag tgacctcagc cccttcctgg ccctactccc ctgccttcct aggttggaaa 5040 gccataggat tccattctca tcctgccttc atggtcaaag gcagctgacc ccatctcatt 5100 gggtcccagc cctgcacaga cattttttta gtcttcctcc ggttgaatcc tataaccaca 5160 ttcttgcctc agtgtatcca cagaacatcc aaacccaggg acgagtgtgg atacttcttt 5220 gccattctcc gcaactccca gcccagagct ggagggtctc aaggaggggc ctaataattg 5280 tgtaatactg aatacagcca gagtttcagg tcatatactc agccctgcca tgcaccggca 5340 ggtcctaggt gacccccgtc aaactcagtt tccttatata taaaatgggg taagggggcc 5400 gggcgcagtg gctcacgaat cccacactct gggaggccaa ggcgagtgga tcacctgagg 5460 tcgggagttt gagcccagcc tgaccaacat ggagaaaccc catctctact aaaaatacaa 5520 aagtagccgg gcgtggtgat gcatgcctgt aatcccagct acctactcgg gaggctgagg 5580 caggagaatc gcttgaaccc gggaggcaga ggttgcggtg agctgagatc tcaccattac 5640 actccagcct gggcaacaag agtgaaactc cgtctcaaaa aagataaata aagtaaaatg 5700 gggtaaggga agattacgag actaatacac actaatactc tgaggtgctc agtaaacata 5760 tttgcatggg gtgtggccac catcttgatt tgaattcccg ttgtcccagc cttaggccct 5820 tcaaagcatt ggtcagggaa aaggggcaca gaccctctca ctcatgtgat gtcatctctc 5880 ctccctgctt ctgtctccta cagccacctg aagtccaaaa agggtcagtc tacctcccgc 5940 cataaaaaac tcatgttcaa gacagaaggg cctgactcag actgacattc tccacttctt 6000 gttccccact gacagcctcc cacccccatc tctccctccc ctgccatttt gggttttggg 6060 tctttgaacc cttgcttgca ataggtgtgc gtcagaagca cccaggactt ccatttgctt 6120 tgtcccgggg ctccactgaa caagttggcc tgcactggtg ttttgttgtg gggaggagga 6180 tggggagtag gacataccag cttagatttt aaggttttta ctgtgaggga tgtttgggag 6240 atgtaagaaa tgttcttgca gttaagggtt agtttacaat cagccacatt ctaggtaggg 6300 gcccacttca ccgtactaac cagggaagct gtccctcact gttgaatttt ctctaacttc 6360 aaggcccata tctgtgaaat gctggcattt gcacctacct cacagagtgc attgtgaggg 6420 ttaatgaaat aatgtacat tggccttgaa accacctttt attacatggg gtctagaact 6480 tgaccccctt gagggtgctt gttccctctc cctgttggtc ggtgggttgg tagtttctac 6540 agttgggcag ctggttaggt agagggagtt gtcaagtctc tgctggccca gccaaaccct 6600 gtctgacaac ctcttggtga accttagtac ctaaaaggaa atctcacccc atcccacacc 6660 ctggaggatt tcatctcttg tatatgatga tctggatcca ccaagacttg ttttatgctc 6720 agggtcaatt tcttttttct tttttttttt ttttttttt tttctttgag actgggtctc 6780 gctttgttgc ccaggctgga gtggagtggc gtgatcttgg cttactgcag cctttgcctc 6840 cccggctcga gcagtcctgc ctcagcctcc ggagtagctg ggaccacagg ttcatgccac 6900 catggccagc caacttttgc atgttttgta gagatggggt ctcacagtgt tgcccaggct 6960 ggtctcaaac tcctgggctc aggcgatcca cctgtctcag cctcccagag tgctgggatt 7020 acaattgtga gccaccacgt ccagctggaa gggtcaacat cttttacatt ctgcaagcac 7080 atctgcattt tcaccccacc cttcccctcc ttctcccttt ttatatccca tttttatatc 7140 gatctcttat tttacaataa aactttgctg ccacctgtgt gtctgagggg tgaacgccag 7200 tgcaggctac tggggtcagc aggtgcaggg gtgagtgagg aggtgctggg aagcagccac 7260 ctgagtctgc aatgagtgtg ggctgggggg cc 7292 <210> 6 <211> 65770 <212> DNA <213> Homo sapiens <400> 6 ggcagcggcg gccgcagaga cctcgggacc cccgcgcaat gtggcaatgg aaggcgcagg 60 gtctgactcc ccggcagcgg ccgcggccgc agcggcagca gcgcccgccg tgtgagcagc 120 agcagcggct ggtctgtcaa ccggagcccg agcccgagca gcctgcggcc agcagcgtcc 180 tcgcaagccg agcgcccagg cgcgccagga gcccgcagca gcggcagcag cgcgccgggc 240 cgcccgggaa gcctccgtcc ccgcggcggc ggcggcggcg gcggcaacat ggcctcggct 300 ggtaacgccg ccgagcccca ggaccgcggc ggcggcggca gcggctgtat cggtgccccg 360 ggacggccgg ctggaggcgg gaggcgcaga cggacggggg ggctgcgccg tgctgccgcg 420 ccggaccggg actatctgca ccggcccagc tactgcgacg ccgccttcgc tctggagcag 480 atttccaagg tgcatttcag actctctcct cccactttct cttccctcct ctaactcttt 540 gggatcgccc ccgccacaca caaacacaca cactctcttc ctctctctct cacacacaca 600 cacacactca ctcacacctc tccaggaaaa gcagcagaca aatggggatt gaaaaattca 660 aaccctccct ctggtcctgg gaggaaaggg ctgtctgagg tccgcagggg gtggaggtgt 720 gtgtgtgtgc gtgtgtgtgt gtgtatacac acgccctccc tggtgtgcct tttccggagc 780 actggaaagc cgtccacggc ggaccacctc aagggcggcc gcggcactgt cctgccccgt 840 gccccctgcc ctgaacttct tcctcctgcg cccctgcccc tatttgcagc ctaaactcct 900 gtacggctgc cacattctt aacatcttgg agggggaggc ggagtggaga gaggcggaga 960 gaggaagggg ggagggagcc gaaataaagg tggtttcctt ttttggcagc cagttttggt 1020 tttgttgagc atgaaatctc tgctccctta aaaaattatt ctcggaaaaa gatatccccc 1080 ccgttttcca ggttttgagc cgcctctcct tagggcctgg tcgggggagg aaaagttgta 1140 aacaaattgc caccttaaat tcgcggtgcg agtctgcgga gctgccgggt tcattgtgtt 1200 tacgaggctc gctgaaatgt gtggaatcca gggaaggcga gcacccagac gggggcccgc 1260 cggggccgcg gccagcgccg gggaaatgcc gcgccgggga gcagcctgcg ccggcctgag 1320 cccttccctt tgcactcggc tgttttttac gtttaaccag aaaggaaggg agaggaggga 1380 aagatccatg tggctgccct cttccgatca caaatattgt cgtaagttgc agctggctgc 1440 cccacttcct aattcagctc acacagcctc tccccacgct atggaaatgc gtcgggagtg 1500 aactccggcg gccgcgctca ccacgtggat ccccacttac taccattctc ggcgggggtc 1560 cagttggggg aacccgcaat atgttgttcc aaagagcgct cgcccctagc gcccgtcccc 1620 gagggtgatg gacagagcag gactggtttg ctggctcctg aaccttgggc tccatcgctg 1680 ggattacgca gcccctccct tctcagctct ggggtgaata ttgtctgtgt cgagtggttt 1740 ctctcctctc tacctcggct tcctcttctg tattgcagcc ccagtgcccc aagtcgctca 1800 gggatcccgc gggtgggggc gccctgatgt ccccgaggtg cagctcccac gctgcggccc 1860 ggctttatga ccgagccccc catgacgctc agatccgccg gggctgcagt ctcgagggcg 1920 agtccgtgtg ccgcggccac ccgcgccccc acggctgttg ggggctcacc gggcgggtgc 1980 gcgcaagcgg gcgtgggcgc gcgggccgcg actccccggc gctcactcct cccttctgct 2040 tcgtccccag gggaaggcta ctggccggaa agcgccgctg tggctgagag cgaagtttca 2100 gagactctta tttaaactgg gttgttacat tcaaaaaaac tgcggcaagt tcttggttgt 2160 gggcctcctc atatttgggg ccttcgcggt gggattaaaa gcagcgaacc tcgagaccaa 2220 cgtggaggag ctgtgggtgg aaggtaagag cgcccgccgc ggcgcccgcg cccccggccc 2280 ggtccctcct cgcggttgat agagatattc gccagcgcac acctagagcc tggctgcggc 2340 cggcgaaacc ccctgcccgc acccggggga ttgtttattg tttgggcgcc tggccgggag 2400 ccaggcccgc ccgacaaagg ccgcgctgta atctactcgg ggcgctgcgc cggccgaggt 2460 gtggtgggag agagcggcgg gggcgggacg ggggcgcggg gcccctccgg gacggaccac 2520 tctgcgcgcc gggggccccg ggcccgccgc cgctgccgct gtccgcctgg gccgcgcccc 2580 gagaggcgcc ccggggctgg cctctcccgg ccccgctccg cggcccggct ttcttctctc 2640 ccccaccccc acccaccgcg tccaaagaaa aaggagtcgg ggagagccag aggccacccc 2700 tccggctggc tggagtgtgc gcgcccccgg cggccgcggc cgccgcgctg gggagggccg 2760 ggggcgggcg cagcgcgggg ctgcggaggc ggcggcgtgt gtggtcctgt ttttggacag 2820 ctttcaactc tgagggaaaa aaacatttgt ctcaaggtac aaaaaacgcg gggtgggggt 2880 ggaaggagtg gaaaaaaaaa tagtaaggca cagactggaa cgcatgtttg caaagtagat 2940 taatgtttcc tcgcgggtgg gggcttttta catggaatta ttctggggga aggctgcatt 3000 ttgcaggcaa agaaaagaaa tgttttaaga acgcggggtt gaagggacct ctcagagggg 3060 ttctgccagt cttttatcca cgttcctcag ttttggggtt cttgagacct tagcaaagca 3120 gttgcagatt taaaatagat atatattttt tcgaagacaa acatttttac attattttgg 3180 tgacaaaggt ttcaattttt ttcccccgct ggtttcttat ttatcttttt ggcaagttcc 3240 aaatcctgct atttggaaac actttaaccc taaacaccac tttgggcatc ccttacctta 3300 caagagggta gtaggggagg gtagaggtga ctaggtagat aattcaaacc aaaatacctg 3360 gagcattcct ccggacagca tgtggaagct gaagagttat gcgcataatc gcttcagtga 3420 tccctttcag gatgctgttg gagaccttga agaatatttc cttaatctct ccttgtttgt 3480 gaagatcag cttgcagagt tttgcaagcc tggggtggag ttggagtatt tagttgagaa 3540 gtgacaatta aaataatagt ctacataatt aagacaaaac attcctgcct taagtagttt 3600 ggtaattaat acaaaagcgt tctttggatt gaatccatgg agtaatttac ctcagttcag 3660 cgattcagta tcactggtag ataaaagaag ggttttatcg agcagctatt atgctcctag 3720 caacaagttt cttgagcacc tatgatgtcc ctagcactgt gttaagcacc ataagagact 3780 caagtgtgtg cgacactgca caatttaaaa ctattagaat tcgatgcatt tggactacat 3840 ttgggttcac agctgaaatg ggctgtgaaa gttacaagag ggtggtaggg ggtggggggga 3900 gagaactgga gacggtaggg gaaggagggc attttaggca tgggcgggac accagcaggg 3960 gccccagctg aggagtttgg aagtgatgtg attggctaga ctgtaggggc gctgccgtag 4020 attctaggac agaatagggc atgaggacag ggagggccgc tgccgtagat tcttggacag 4080 aatagggcat gagcacaggg agggccggct catccaccac ttgatccaac ctgtatttgt 4140 tgccatcgga tgaggatgac aaaacgtgat tttgtggtgt tcttagcaag agttttcagt 4200 ggacctttga catgttgaag gagatagaat gtgatttatt ttcttaacat tgcatatttc 4260 tggaaataac ttgctttctg cataacacga cccatttcaa gtcctggaag gagatgcagt 4320 gtgcttccta gcagttttat gggagctgcc agttgtgtag tgagagggag taaagttttt 4380 ctttttcaat ggactggatg aggacacttc tgaggggcac actcactttg cttacttttg 4440 gcagtttcag catgactcac tggtcttggg ccaaatgtta tttactcagt actaatactg 4500 tcacttgttg agcaactgcc atgtaccagg catttgttat atattatcgc atgccttacg 4560 attcaataaa atagctatta ttatcttttt tttttttttt tttttttttt tttttttttt 4620 tttttttgag acggagtctc gctctgtcgc ccaggccaga ctgcggactg cagtggcgca 4680 atctcggctc actgcaagct ccacttcctg ggttcacgcc attctcctgc ctcagcctcc 4740 cgagtagctg ggactacagg cgcccgccac cgcgcccggc taattttttg tatttttagt 4800 agagacgggg tttcaccttg ttagccagga tggtctcgat ctcctgacct catgatccac 4860 ccgcctcggc ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc cggccctatt 4920 ttgtttttat aacatgatag tggatgtaat gtctttatga tgaggattgt cccattttac 4980 agatgggaaa ctatgggttg tctgtttgtc tccaggtcta ctttgcctac taatgacata 5040 agtcacttgt tctgttgccc tgtccttgat ctctcattca ttcattcatt cattcattct 5100 gtgctagatt ctccccctag agaagaagcg acagtttcat aaatgcagat agacccaact 5160 agagaggtga ctatacaaca gtagccatat agatttaatt tcattttcaa agcagaagtg 5220 attgtgtaga gatcttgttt gtgacagagt gagctgagtg ttcacgtcag cagtaagtag 5280 tgtgagcatt tgcattcagg agtaagattt ccctgctgtc ctatacctca gtggacgtcc 5340 gtgaattgaa gtgagtaata gctccacatt taagttcatt ttgtgcatca gtctcataga 5400 taaattcctc atcactatca gcaaagaaat ctgttagatg ctgctttctt ggtaggttgt 5460 tcttaaggtt ctagacatga atttttatat gaactgggca tcaacagagt gcttgctaca 5520 caaacgaaat ggatagaggt agcatattgc cctagttaga aaacaacaga agagaggaaa 5580 gtatgagatt ttaaggggag agggatgctg agggatagtt tggaagaagc tccttctcct 5640 gcggtttaaa atcacaggag cgtgtgtgtg tatgcacatt gtcttattct gcatatcctc 5700 ctatctgcca aaggcatgtt aatgttatct ttttaataca gccagcaaat taaagggatc 5760 cactcgaaag gctgtgtctt caaattgact ttcatgcttt gtttaacatg ctggggaaat 5820 gtggctttat aaagagttgg ctttataaag agggcagaat acatcagcca caatgtgcag 5880 actaatatat gctagatgag aaagagtccg tgtgtgtgca tgcgcgtgtg tgtgcgtgtg 5940 taggaattgg tgataagaat tattgtattc tgttgttaaa atgtccatat aatgattgcc 6000 ttttaataaa ctgtcaatta tatgttaaga taccagcttg agttttaggg ttatagtgtt 6060 tgctaatcaa aattgtcaaa tcagtttcac atatgtgcgg agtaatgagg tttgatagag 6120 aatatgttga ctgatgtagt ggacatctgc tgttgcagaa acacatgacc atggcagcaa 6180 ggtgggggag aaactaattg tcattgtata aaaatagaag cgttcattct gcacatgttc 6240 tcagtaccta ctctgcacca ccattgcaga aagctctcca gagagatgtt ggtgaaaagc 6300 cacagtctct gccctcaggg gaactccatc caaacattca gcaggtacac ggactggtgt 6360 gtgggtagtt aacatgaagg acagcagtgc caagatggca ggaaaatcgg ggacatcttc 6420 caggatggcc tcaagggtgg aggcctgagc taggcacagg ggctggaggg gagagggtag 6480 ggggcattca gggcagaagg aacagcatag gcaaaggctc agagaacagg aatgtggcct 6540 cctggagggc agcctccctt tgtgggtcgt tgaggttggg tgggagcctg gaagctgggc 6600 tcgtccctca gggccatttc acagaagtct ccctgcttgg ctgggggctg tcagctcttc 6660 ctactagcca tccctgtctc acgagtgtgc tcacgtgttg gcctctagtg ttttccctgg 6720 agccacgaat gcttcacctg gatctcacct ttctgggcac agactggtgt tatttttaat 6780 cttgcctgtt tctttgttgg tatttccttt ttgttaagca gttttaaccc atctccctca 6840 gtatctattt cttttcatat cagccccctc actgcagccc tccctcagaa caagtttctt 6900 gtcaagcttc tccagcgata gaacattcat ttatttcttt gagctttttg ttttttctaa 6960 aagcttgccc agctcctggc ctccttttct gcagagggca gcagccttgt aatgaatcca 7020 tattgctttg gtgtttggat gttaacattg ctgcaggcca gcgtcaagga agaaggaggc 7080 aagttgtgac tttgactttt tttttttttt aagaaaaata gaagaaattg ttttttaaaa 7140 tacatgcttg gtatgtgtaa gtgctttcaa gtttgtacct tgctagtgtt aatgctttca 7200 gtgttcttga actcaggcaa tcagttgtag gagataactg agtttcacca ctccttcaat 7260 ttggagcaag gtccctcaac ctcaggacta ttgacattgg ggctggatca tcctctgttg 7320 ttgggggctg ttctgtgcac tataagatgt ttagcagcat cctggtttct acctactaga 7380 tgccagtagc accctcccag ttgtgacaac cagaatgttt ccagtcattg ccagatgtca 7440 ctgggggaga gggtgtccca aatcatcacg attgagaccc actggtttag atgataaaaa 7500 gattttgatt ggaagactca tgctgtgcag atggaagacg tttattatga tggagttgtg 7560 gctacaatgc attgcagaga tgcaagagta ttaatcttct ttaagataac tcccccatcc 7620 cattcctgta tttatagacc cagataacta tttttcttag aatgacatta aatgtcaaag 7680 aaaaacaccg tgatgggtcg aaagaggaaa gaggccatgg aagaaagaaa taatttatat 7740 ttgggtacct tttggtgggg ggtatctaaa tttgcagaaa gactggttgc acctcaaccc 7800 cagtagcctg aaggttttta gcatggttga ctttctgaaa agctttaata gaagacacca 7860 ctgcctttgt gcatattgaa ataacagctc cttcagaagc ccggctagtg tgtgaactcc 7920 ttggtggtct cattctcctc cagatgtttc tgtcacaaac cactccccct tgtcccccca 7980 ggagcccttg tggagcagaa ccaagggaca gcaagggacc agtcccagcc agaagggcag 8040 aatggattct gctgtcactg cccttccaca gtgagcacct ggtttctttt ctctggggtt 8100 gccattgtgg gggcatttca caagggacag gaagaaaaat gcagctcctt tctgctccct 8160 ggacccccat acatggttta gaagggagaa tatgtttata ggtatttatt agtttctact 8220 actgggtatg cacatttagg tggaagcagt tgtgatattt ctttcatatt tggagaaaaa 8280 cgattggaaa tgagaagcca ccaatgattg tttaaaaaag aacaaatagc cctcaggtgt 8340 cttctacaca gggcagttga ccctgcgaat cctccctatc tctttgctgt ctgccattct 8400 tgacccttca ccaagttgag aggacaggtt gggtaatggg gtgtttcaga tacataggat 8460 gccgctcaga ggttccagaa gatgacagct tccagatgta tgaacagcct gatccgtgtg 8520 tttagattat gcaccacagc tgatgccgag attaatgctg gctggacaag ccatgggaga 8580 tttgtctggt ttccacaatg ccatgtttat gtttcatttg agtttctcct tcaaagctga 8640 cctgcctgtg accctgggct ctgtccactc gggcaagctg aaactcgggc aagctgaaac 8700 tcgtctgccc tgttctcctg cttgtattgg ggtaggggag agtcacaatt gggcggagaa 8760 aggggcgctt tggtggccgc cttctgcctc accatgccag ctatctgccc agatttagcc 8820 cctgatgagt gttcagttct cctcggggat gtgtttcact gtaaaaggtt ttttggcttt 8880 taaaacaaat atggaaatat tataaaataa ctgtaaaggg gaccagattt aatagaagcc 8940 actttgcata aatgtagtat tttaacttct ggcactcttt tgacactatt tagggggaga 9000 aaaagttgag ggaatttcag ctatgtcaga cacccccaca taataaccat ggctgtgtca 9060 tcctattata atactattaa tgtttcctgt gcccctcgct ggctcccaga acctctgctg 9120 cctcctccct ctctcccctg cccccttccc tcctgcccct tctcccgccc acccactcta 9180 acctgcccac gtcatttcct tccaagtgga tctctgcagt tactagtgtg aactctgaaa 9240 tggtagtaag tctggctaat cacaacctaa gaggagggaa tgagaacatt tattatttca 9300 agccagctgt gggagatact agatacagag ctgccatttg catccttggc attcttattt 9360 tggttagggt tggttccaag accacactct ttgatgggct cttggcagaa gatgtgattc 9420 ccctgttgaa gaatcatgac tttttttaat ggactgctga ggcaacttta aaatccattg 9480 acaagtttct tcaacccata ccacaccgcc agagagagtg ggaaataagt cttggtcccc 9540 tgtgcttacc gtggcgcatg gacagtggaa gaactgggtt ccctagcatt tctgagacag 9600 tgagtggagc acaaaccatg gctttccctc ccaggtgccc cacttcaggt cttccttgct 9660 tagaactccc accaaagcca gtgggcacat ggagcttggc tagattgaag acgatggaat 9720 tccttatcca gattttggcc gactctgaag ctttatgtgt tccatcctca cgagaggtct 9780 tggttgacat ccagagacca gagggccttg ctggtgaggg cacttctgcc tgcaggagga 9840 ggaagctctg cgggattctc tcagtgggaa cattccttga atacacagat ataatcaggg 9900 tcatcaaaat ataaacactt ctgttacttt ctcttctaat ctttgaattt gggtgcttat 9960 gataatactc actggatttt ttttttctct ttaaattgga tttagggcac tttttttcct 10020 ttacactgca atgtctaatg ccttccgtac agcagaatac tgccattgag aaactgctgg 10080 gctgtggtgg aggattttag gagcctggtg tacaggaaga tgcgccccat ccttagtccc 10140 tccaggaggg aatatgactg ttccatttgg ggtttagagc atggctggaa aaacagctgt 10200 catgtgttag ggaaactgta ttgttggtgg gcagtcagat acctgctaat gaatggcaag 10260 tttgttgttg gagagattta taatgtgggg gcaggacctt atttctaatc cagaaaccca 10320 ggtgtgagtt ggcccaaata gtccactctg catgtgggtc ccataatgcc actgctatga 10380 aagcaaggct agtgagaagc aagtccccat accacagcgc aagctttatt tattattgtt 10440 cggataaatg aaaagaagca gtagacttac ccaatttagc aaccaagata gttttcagtt 10500 attaatgaga catgtataaa agtaagcaaa aggaactgga aatgggcttt gttaagtcaa 10560 tgtgcatgat tttttttccc ccttaaatca ttgcttaagg gcttctggcc cctagctcag 10620 gaatcctgcc caaaaatgcc agatgtatta cacagtcaag tattgcaatg taaacaccac 10680 tccgtgccac gaggcagggt ggtccatctc ctatttaaga agagtgcgag attgagagga 10740 tggggggtgg gggggtaaac cctctgctct gtagtgagcc cagtggtggt tgtgtcattt 10800 gtgtttttgg ctgcacagtc aagatttgaa actacaaaac ccagataaac acattggaat 10860 ggcaaagaat agcaacttga attgggatgc caaacaaatc aagatgtggc ttggatagtg 10920 ttgcttcatt gggtcagata agtttataaa atgtgggaca gaatggaggg tggggagaga 10980 caggaagagc gctcttgtca cagcagcatc tttaagttgc atgagcatcc tgttattcat 11040 ttgctggtgg ttaaatggaa aggtgagtgg aagcgaggcg gagagagccc gagcctccaa 11100 gatgacctcc tccgtgagag gaagccctcc cgggtgggtg caccttccaa gcctggaaaa 11160 gctgatgggt tgcaaagcca gtctggtgtt ctgtggcact gagggatgta gcccacgata 11220 tgttctgaag taaatggctt tccagttttc tcctgctttc tgcatttctg aagtaagaag 11280 tctgctaatg atgattgttc ggagctgaga aagtcactgg cactttgggc caccctccgg 11340 tataacgtgt cgtacgatgc tgccagcaat gacaggaaat tggagtaccc aaatattacc 11400 tatccttcca gatagcctaa catgaagcag ccctgagagt gactacactc agggttttta 11460 aaaattaata cgaacatgtt ttgtgagtta ggaagaaata ggatttcagt ttgaatttgc 11520 ggaattgttg aaatacctgc gccaatattc tcctgattaa gaaatttatt ctacagagtg 11580 atctgagaaa acggctttaa gaaatagtga tgataaaaac aggaattttg agatgaagga 11640 aaatgtaggc ttcttgactc cctctttctc ctcccaccgc tgtttttttt ccttttgtga 11700 attcttccac attcccaccc ccactccctg atttcctctg ctcctttact gggaaaccag 11760 caaccttcac aaaatagact caaacatcac acagcctctt tttaaataga ggctttctaa 11820 gagaaaataa caaaagaatt tttcctagct gcctaagaaa ttctttcttc ttactttatt 11880 ttcctcatga gatttacaca ttgttgtaat aagtaaaaaa tgataaatat gataccatca 11940 ttttggtcta cacatgatcc agaaaaaaaa attgcacatg tttaatacct tgcttaattg 12000 caaacaaagc ttgcaatttg agagaattgg gattagggct aaatatctat taactgctct 12060 ttctagagat ttggggacta ggatgaccct tttttttttc tttttttttt ttaataggct 12120 acagtttcac atggctccca aaagaaatct ctctcccttt ttgtttccca caccaattga 12180 tttatcattt tgcttgcaag cagatccaga atgttagggc aagaacacac tcactttttt 12240 ctcgtaactt ttttgttgcg gaccgaaacc agttgacttg aataaatttt tctgaggcct 12300 gaatgtagcc agcaacgtgg aaaaatcttg ccattcaggg ccgtctgaat gtacatttca 12360 gccacacagt aagctgcatt gggaggcgct ggactgctaa atgcaaccat ttttcgcagc 12420 agcgagttag acaggtgatt agcataatta gcaccgagca gctatacata tggtaatgct 12480 gagtgtgtaa atgccagctg cggtgtaaaa tttatgtcag gggtcggcag ggctgtgcga 12540 aagtattgtg ttccagctgc aggtcagggc cgccaaagct tacctccttt tctcttgttg 12600 gtgaatacgc caaacagaag agaaagacag aaatataaca gatacggctt tgatgggaca 12660 gcccagttct gtgcaagagg gactgctcta taaaacacac acactcacac acacttgcag 12720 aaatcccatt actttctgta gaaatcgtgt gtgtacttca tgcagggtcc agatgagtgg 12780 ggccgggatg gaggtaggta aatgattccc tgggaggaaa aaattcagtc attgaagttt 12840 taaaaggagt taaaagttct gttttgtttt tcttcccacc catcctttta ccccccacac 12900 cattccctcc accactctcc tgcccacatt gtcttatttc acattagatg gggggatatc 12960 cttgctggat gggatagcat tggtccttta gaagaggagg aactaaccgt tctggaggtg 13020 ttagccttga acaaaatata aggtttcagc agtgcaactc ttcccaaact gcttgactag 13080 ctttagaaag gggctaaaaa aagcttttgt gggctttttg ttcttcctct gggtagctat 13140 acttactcgc ctacctatac ttactccccc tacctccact gtcagaccca ccaaattctt 13200 tatagattta aaaaaaaaaa aagaatcaca tgggtttctt gtttgaaagg atagtcttga 13260 atggctcaca tactttgaaa tgcatgatgc gggaatttat tgctatgatg agtttataca 13320 ttttgcactt gaggtatttt ctctgccacg cccccacctc cacccttccg ttttttggtt 13380 ggtggctata agaagtggtg gtgttgacag aatatagttc acaccatgct gacccggtga 13440 tgaaacttcc tcacggcacc agggggtcct tatgtactgg cccctaatcc agctaatcct 13500 gatggcaaca aaatcatgaa agtggccccc agtgacgtga gtctccctgc acagatgcag 13560 agggaaggaa cagtgcagga gataaatgag gccagcgtgg tattcaccgg aggccaggga 13620 gcctgcgtgc gaaggtggag actcgcattg tcttctcccc catgtcggct caagtgggag 13680 gccaatgaag agaggcccag gctggataat ggcaagaaga ctgttcagag ctgagaggtg 13740 atgtcagccc cacagaagct gagagaagga aactggggtt aatgttatgc aatgccttga 13800 gtgctgtgat ggagagcctg ccgtggaagc acttgggttt tgttgttgtt gttgggtttc 13860 tttctgtttc tattttttta atgaagactt caggaggttt caactaagct tgatgaaaac 13920 acgctgtgtt ggttcctggg ttctgctgcc tgctgctgct ggagtgtggc ctctgagcca 13980 gcgcgcgctc gtcatcacac ctctgggccc gcccacttcc tgcagagcga cgggacctgg 14040 gtgtgcatct gcctgcctgt tgcgcttgag cggcctggtt gcacctgagg ttgtggtaga 14100 acctgggaca gttcccagct tggaaagtac gctgttccgg atggaagaca tttccgcctg 14160 tgctctgcag gaagtcagca acgttcttgg gcctgtctca ggtggcgcgg tgcacagccc 14220 tcatttgcca gtgtggcaag taaccaatga agaaggggcc tcctggcaga tgcagcgtcg 14280 tctcgggaac tcgtggctcc ttgggagctg gtgggagctg cgacaggcag caggtccagc 14340 gtgggcagag tgccgggctg acctgattgc atctgacagg gcgagcaggt ctgcgtcagg 14400 gaaagccatt cagagggagc agcctgggca aggctgataa cagatggcac tgccagcagc 14460 tggtgggggc ggggaagctt gcttccggcg catgcgcgtt gcagaacccc gcgcgagcgc 14520 ctgcgcacta cctgcgccca gcctgccaca tgccccgtgc ggtcccgtgc ggttccgtgg 14580 gcaggtgggg gtgtcctttt ctcgttatgc tttggtggtt gacctctcac tgggctcact 14640 tcatgaaggc acattctctt tgggctgatt gtagcgtttt tcccatggca acacgcaggg 14700 gcacaatctc ataaggaaaa aaacggccca gaaacttgga cagcggttgg ctcctcctga 14760 ataaaagaga tgggtgggag aggactaaaa ttcacagccc gtgaattttc agccaattgc 14820 tcacattact gaattttctt ttttttttgt ttttcgatta taaaaaagag gcagtgctaa 14880 taattttgca gttacacccg cttagagatt tgtacttttt cggcctcaca gtaagtaaat 14940 gcaacattga aaggaggacc tgagcaacta aaagaaaaag aaaatctctc tagaggctgt 15000 tagataattc atgggattaa tcaaatgcaa atgcaacgct tgcatataca cagaccctat 15060 tttcctaatt ggactctgag tgggtacttt tcaggctgaa agggtcattt gttttgactg 15120 attgactttt tgaggctttg gggggaatta ataacttata cagatgactg cctgttccca 15180 aggctctgta ttgagactgc gcattcattt attcattcag cacacttggt gtgccatgcc 15240 cctggtgccc ctctgcgtcc ctcacatacg gaggtgcatg ggcaggactt gaattttgtg 15300 gaaaataact tcggttggtc cctcagatca tctttatgtg gatcacaata agcttttgct 15360 aaaaggtttt tgtgtgaatg acacagaagt ttcttaagct ctgtgcagaa ggctgtgctg 15420 aggaggggca cagcagggaa gcgtgatgag ggaaacatct cttgtctaca gtggattgga 15480 atcatattgg cctagaagta tgggcctctg ggtcagctgg catcccacct gagctagcta 15540 gcctttcttc actttggaaa gttaagcctg gcttgatttg gggatgagag gatcagcaga 15600 gcttgatcaa aaacttattt gcagaagtga tgcttctttt gcctttcaaa gaattggctt 15660 aagccttgga tttctggaga ataagatggc agaatttgca ggtaaagagg cttagggctg 15720 catgttctct gtgtgccttc atctgccccc tctaagacag gactctctgg ggaccagaag 15780 gaaaatgagg cctgtccact gtgacccagg gagccctact gaaaaaaatg catctcctca 15840 ctggctgaga aaagtctttg atgcaacatg gttgtacttt aaataaaaat acggattatt 15900 gtcatatttc acgcattcta aaattctagc tgtgagcgta atacaggttg agtatccctt 15960 atacaaaatg tttgggacca gaagtgtatg ggattttgga tttttttaag ggggggtgat 16020 attcacacat aagcatgatg agaaagcttg aggatgggac ccaactctaa acatgaaatt 16080 tgtttatgtt tcaactactt tatgcatcta gcctgaaggg aattttatac gatattttaa 16140 gataattgtg tgcctgaaac aatgttggtg tatattgaac tgtctgaaag caaagatgtc 16200 actatctcag ccacccatgt ggacaatctg gttgtgtggc attcccatcc ttcctgactt 16260 aaaatttata tgctgccgat aagcaatcat tttcttaaac taattcacac ctacgtactt 16320 accagtaaaa aaaccacgac attccattaa tgcagtgaaa aaaataatgt gttcagggta 16380 cccaagcagc acaatagcat caccagatac ctgcatcagt ggctaaacaa cagcagcttc 16440 cggtctccac ctgcaatgct gtgttttcac tgagaggtta ctgtacacca tgttttattt 16500 ttttaggtga gaagaaacat cagaagcagt tgaaggatca gggagtgggt tgtgtagggg 16560 cgaggagaca tctgctggat ggcttttcag aatgtttcct ccagcatcac cggcctcatt 16620 aacaatagtt tctgtcttaa gacgtctctc tttgatttta tgaattgaca tgatttcctg 16680 tttggttgtg aatgcacgat gcgttagttt tcaataagcc catcacacat ttttaccagg 16740 tctgctatag ttaacttttt gtgcagttgt aacatgtcat cttcatggtt gtgagcctgt 16800 tttgactgtg actgattaca tgaggtcaga tgtggaattt tccacttgga gcatcatatt 16860 ggcactcagg aaggttttgg agcatttgag accttcagat tagggatgct caacctgtct 16920 agtgtgctct gtggaatttg gcactcctag gctacctcct gctgtactca tgttctcagc 16980 tggtgctcag aaaccatgag gctcgcaggg tagttggact ctgggttaaa gggtcagttc 17040 tgcctcttac taataaggtg ggcaaccttg ggcaagccac ccaaactctg cagctatgcc 17100 ccctcccctg taacatcagg acagtgaaac aatgctctgt gacaaaggca tgggtgaact 17160 gacacttgct ccgctcttgg gtaagggtct gggaaatttc acacacattg tcagctaagg 17220 ctctcacagt cctgtgaggt tcatcacagc atttgttatc cctgttatcc tcagcaacca 17280 ggaaaggtgg ctgaggctca gctgtgtcag ggacttgtcc tagatctctc tgccactagt 17340 ggcaatgctg gggtcttccg gtttccattc tcactgcctg tctggtacag ctggccccag 17400 cttgatggag gagcagcaat gatcaaaata tttccaaaga cgtaaagaat atggtctcaa 17460 agggctttgc aaatggaaag caccacccaa gtataaaacg ttattttgtg tctcaggatc 17520 ctgagataat gatttttctt gagtcttgtt cagaggggtt gttattttat tgttaatata 17580 aaaggacttc agaatatgat gaagatgcat atgattattt ttatagttta ttagtattat 17640 tgatacataa tactgtatat atttgtggtg tacatgtgat gttttgatat aagcatatga 17700 tgtgtaatga tcagatgagg gtaattggaa tgtccatcac ctcaaacaca ttcatcattt 17760 ttttgtgttg agaacattct aaatcttctc ttctagctat tttgaaatat acagtgtatt 17820 gttgttaact gtagtctccc tactatgcta tggaacacta gaatgtattc tttctactta 17880 actgtatgtt ggtactcatt aacccacctc tcttcatttc ccctctcatt cttcccagcc 17940 tctgataacc ctcattctac tctctaagtc catcagatta atctttttta cctctcatat 18000 atgagtgagt acagagatgc ctattttttt ttgcattgag tttgttttta attcatatct 18060 ctaccaagta gctctcatat ctatctttct tttgtgtgtg tgtgtgtgtg tgtgtgtgtg 18120 tgtgtgtgtc acatagaagg ttttgttttt ctgggttttg ttttgttttg aagtggggtc 18180 tcattctatt gcccaggctg gagtgcagtg acacagtcac agtgcactgc accccccaac 18240 tcctgggctc aagcgatcct cacacttcag cctctgaagt agctagaact aaaggcagcc 18300 tccactactc cacagctatt tctttaactt tttatttgta gagataaata cgtttatctg 18360 tgttgcccag gctggtctcg actcctggcc ttaagtgatc cttccacctt ggcctcccaa 18420 agtgctggga ttacaggcat gagccaccat gtccaaccat agaagctttt aattatactc 18480 tttcattgta gaaaaattga tagaaataaa ctcaaaaaag caaagcgggt aaatattatc 18540 catagtccgg ccaggtgcag tggctcacgc ctgtaatccc agcactttgg gaggccgagg 18600 tgggcggatc acaaggtcag gagatcgaga ccatcctggc taacacagtg aaaccccatc 18660 tctactaaaa atacaaaaaa aattagccag gcctggtggc gggcgcctgt agtcccagct 18720 acttgggagg cttaggcagg agaatggcgt gaaccctgga ggcagagctt gcagtgagct 18780 gagatggggc cactgcactc cagcctgggc gacagagcaa gactccgtca caaaaaaaaa 18840 aaaaaaatta tccatagcct accacacagc aaaaatggct attaacttgg ttccctatgc 18900 ctacatctac ataacagata ctagatttaa tagttatttt cttctgcact atttcacgaa 18960 cattagatta ttttaaaaat atgttaggac tttgatcctg acagtggaaa aaagtcatgc 19020 ctgaaatccc agcactttgg gaggccaagg caggaggatt acttaagctg aggagtttga 19080 gaccagcttg ggcaacatag tgaggccccc gtatctaccc aaaaaaatga aaagttagct 19140 gggcatggtg gtgtgtgcct gtagttggag ttatctgggg tattagggga ggaggatcgc 19200 ttaagcccag gaggttgagg ctgcggtgag cagtgattgt gccactgcac tccagcctgg 19260 gcaacagagc aagaccttgt ctttaaataa aagaaaaaga agggggaaac ctatttctcc 19320 aagaccatga ccttcatctc agtcatctaa aatgggttct gtgggacttc ctgagctcaa 19380 agcttcacac ttagggatga taaggaagac agcaagataa tgaacagctt tcagctgtca 19440 ttcagcagtg atttaggata ggcgtttgct agggtagcaa atgtcagacg agtcagtaaa 19500 attgctctat cctgaagggt ttctgtttct ggcagcttgc tccagagtgc cttgggtcaa 19560 tactgatgtc agaatatatg agtgtcgtgc actttatgac acagttatac ccgagaggga 1920 gctgattcta ccagttcaca tggtgaatga cacaagactt aattatggtc tcaccaagct 1980 ccgccacact tgcctccctt ctctccctgc aacaagccaa acctgagggc tttgcagttg 197440 ctggttcttc tacccagaac gctgtttctc cagctcttca aagtcaccta aatgttgttt 1800 ccctttaggt cttccctgct atcccatttg aaatatcttt tccccttccc cactacccaa 19860 catggcatca ccatcttcgt tttctgcatc acacttgtgc tatgaaggta tcttattgtt 19920 ttgcttggct gttgcctgtt cccttcactg accagcatgc ctcttggaga gagactacgc 19980 tgactggttt cgtccaccac atccccactg cctggtcaaa gtacccaccc acccacccac 20040 aaatgcttgc tggatgaatg aatcatgtta cagctattgg tcagataaaa tgggtggcaa 20100 ctaaacttca ttaacgtttt tgaatcattt tgcaaaacat tcatatttgg ttaaatataa 20160 gatgaaatat tagataaaat ataaccatat aatatgtaaa agtgaattgc atttaatagt 20220 atatatggca taggtggttg agaaaaccgt agacttcaga gtctcaactc tagttgcttg 20280 gccaccctat catgatagtc ttagttgaaa catcacattg gcaaaatatt tgtgttcatc 20340 attagagcaa agagatgggg gagcgacagg ttttccaatt ccagagaaag gacaaatcta 20400 tacctttatt aaaatgttta tgtaaatata catcttaaaa catctaaaaa ggggacatga 20460 tggagaccct gaggtacatt ttatatcttg tagaaaataa atgccatttc tgaaacaccc 20520 tgtgataaaa taactgctcc attatgaggt tggtctggaa gagtctggta aaaatttctt 20580 agcagcacaa actttgtgtt tggttttgcc atttttgtgc acactgcact ctcaggtcac 20640 ttcgaggatt atatagttaa caggcggctg ctctgccaag gctcgagggg cagaatcttg 20700 ctgaagccag gctgtctgtc atggactgct cctcactata acggcaccta ggtcaccata 20760 ataagggtgg ggggtgtgct ttgttgctgc tgttttttaa tttcatgggt ttaagtcacc 20820 tgatatgtta agcttcagta aaggtgcagg aggtgcaact ttgtaatcag aatgaaaaac 20880 cacgtgcatg ctgatgttcg aggaggcagt aacaatggga atgatttctg ggtttgtggc 20940 attagatgtg ataacacaaa gaaagggtga gcaaaagctg cattgagctc cttggtgggc 21000 agctctgcag ctgtgacctc tggactcata actggctttt tagcctcata cagcttctgc 21060 acttctaggg gatgtgggct ggctcaaatt cagttaattg gttggaagtc tgcgtggtgt 21120 taagtactgt gctttctgct agagtgagca agcccctgcc ttcaggcagc tttcccaggg 21180 cttgcagaaa aggccagccg agtaggtaga tgcttctctg tgcaagttgt ttcccagtgt 21240 tttcctgtga tttttcctta acttcacatt gatggcaagg ccctcggcaa tgccccctgg 21300 catttttcaa agttttctgc acacagaagt cttattcctt tttattaacc aactgatata 21360 ttcctccctc cttcccgacc ccacacgcag tatgttaaac ctcacctcac ggagctcctg 21420 gccttggcat ccgcgtggac ctgcacagag ggtcctgcca ggcggtgaat ttgtactggt 21480 tttcctaatg agggcattat ttgcttttta gcctgccccc ttgtttataa aatatgccaa 21540 gagaactaaa caacccgctg ttcccagtcc ttatttactt gtccaaacca aatgtttatg 21600 tccttgaata ctaaacttga agaaaaagga ttcctcctcg tgggaaagct atgatcactg 21660 agtttttttc taaactgtcg ctgcaggcct gcttttcagt caacatgcaa cttatcaatg 21720 actttaggaa caattcagac ccgcttcctt tgccctagac tgtggagtgg gggagctcta 21780 ggttcctggg tctgtaacta ttagtatctc cctgagacac ctcccagccc aggtgcagca 21840 ttcggagctt ggcttggccc agaaccgttc attgaacata accttgggcc taaggatgta 21900 aaaaggagag gaagagaaaa ggcatttggc agtcacagtg ttgatggttt tctttggtca 21960 cctgctcctg cgctggcttt gggcataccc cgtgctggcc agcttgctgg aaagctgggt 22020 tggtgtgagg caggacttct cggcctgggc agcaggttca gggtcacctg gggtgcttcc 22080 ggaaaacagg ctgctcaccc ccagctgact gagaacctgg cacctgtgtt ttctggatgc 22140 tgaccaggtg cgtctgatgg aaccaggttc cagggactgc ccatgatggc tgtggctgat 22200 acagtttgtt cctctcaatt gggatttccc catgggcatc tgacttgaat cactttattt 22260 atcttctcct ggcaagtttt gtgctgaaca cacactggcc acctttcctt gtttcttttt 22320 ccacagagga gaaacatttc cttgttacct ttgccagttt acttaggaga agagtgtaaa 22380 ttgaagccat ttatcttgaa atctgctgca ggggcgcatt gtttatacaa gtgaaagaaa 22440 ttgtaacagg gttatttggt ctggtctgca aggaaaaggt gtctcaagtt ttcctttctg 22500 ccccccactt tcgtcacaca gtgtattagt tagaattagg tttgtgtctg tgacaggcgg 22560 gacagccatt aatgggctta gtgagtattt tttatgttta ctattggtga agttaacatt 22620 gccattaata aagtgaatgt tactgctcac acatcagcca gtctcatgac tagagttcat 22680 ctattgtgta tcctatggca ggtagtcaga taacagataa aacatgagtt tgcagtgatt 22740 ttgctattct aattaaacct gtacatattt gtcagttgga ggacgagtaa gtcgtgaatt 22800 aaattatact cgccagaaga ttggagaaga ggctatgttt aatcctcaac tcatgataca 22860 gacccctaaa gaagaaggtg ctaatgtcct gaccacagaa gcgctcctac aacacctgga 22920 ctcggcactc caggccagcc gtgtccatgt atacatgtac aacaggtaag gcccgccgcg 22980 tccacctact aatgagcagc aggtaaggcg gtgggagaag gctgctggtt taggccccgt 23040 tattttagta aatgaagttg ccctggaaat gcacctggag tattagttca aatagctttg 23100 caatgaaagg atttttttca tcttgattta tcgtttctcg agtttggtaa caaagcaagt 23160 gcattacttg ataatgtatt gccagtaagt atcttggcac tgtccccaaa agaggatgac 23220 gctgagccac ttggggacta tacacccagg ctgtaagatg tttcattgct taagagattt 23280 ttggagagtg atattttgaa ttgcccttgc tgaacttaaa aacaatgcga aaaagaagag 23340 ctgcttcttg tgactttgta ctcttagttg ttttgtgtca cacagcacgt tgggggctga 23400 gccaccatgg gaattgttgc tgacaccttt ttatttattt ttttgagaca gagcctcact 23460 ctgttgccca ggctggagtg cagtgatgta atctcggctc actgcaacct ctgcctcccg 23520 ggtttaagcg attctcatgc ctcagcttcc caaggagctg gggctagagg cgcccaccac 23580 cacacctggc taatttttgt attttcagta gagatggggt ttcaccattt tggccaggct 23640 agtctcgaac tcctgacctc aagtgatccg cctgcctcag cctcccaaag tgctggggtt 23700 acaagcgtga gccaccatgc ctggcccgct gacacctttt taaaaagtca tgttttagca 23760 tcgtattgct aatttcacaa tgctgtgagt agagtaaagc attaggaaga gttcaaaact 23820 cggtcctttt tcttatgtat ctagactgtt ggttactaca gggcaggggc cacctcttgt 23880 ctgttttcac cccagcattg agaacagagt gggcattcag tttgttgatt gcttttgagg 23940 ttggcatcac taaaccccat ttccagggga cctctgagtt gatgtcaccc aaccccatca 24000 cctcccctag gctttcagca cctcttcact gaggcctttg ttagtactgt ttatttttcc 24060 tggaagaggt gaggaagtag cagtataggc atattcagca gccagggaga accaaagaag 24120 agaataaaat taagattttt cttgtccctt ctctaacctc tgcttacatt ccagctcgac 24180 aggatcctag ggacaagcac agccagggtc gagtcacatg tctttggcac attcttgttt 24240 gtttatctgt aacctgggct tatggtcatg tgtgctcgta tccttcatgg ttcccagaac 24300 aagaccagat acatgaatgc aagggcctta gaaaatgtaa aatcatgttt ctgccaggca 24360 aacttgccct gttggtctgt aacaagtatt gtagggaagc aactacctgg tacagttttg 24420 cagaatgtga agtggcatcc ctgtggggag ccaggttgtc ctggggccac tgcaagcatg 24480 gccaatgcat tcttagtgtt tgtcacctac atgcttcagg agaagatgtg agggtctgtg 24540 ccattaaatt acactcttaa gctgagatgg gtccagagta attttatgca ttggaatgaa 24600 ctttaagaac atgtagttca acccatccca tgttttaggt gagaaaactg ggaattagac 24660 taattagagc atttgtccaa gttcatgcag ttatgaaatg agagagccag gtttcaaagc 24720 ctttttctgg cttcaagccc attcattttt ctaatgcaca atgatgtcct tctcaagtgt 24780 aaatgagagt tgatcaagta atataaagtg agaacctact catgccggat agtctatgtt 24840 gatgctgtat agaattaaaa tataaatatg tccatggatg tgtggctagg tggaggatgg 24900 cggagatatg ggtaagttag gcacagctct caaagagagg aaagacatca gtatagatag 24960 acatggacaa aggaaacgtg ggcggtcccc atgacagctg cgccaggttt cagcaggaga 25020 tctgcccagc cagggctcta gagttcagga gaagggggtc attttcaaca agcttaacat 25080 gggggtgaca tttcaacagg gcgctgagag acaggaaggc acagggaaga ggacacagta 25140 agctccttgg gtgaagacag gcctccctta ggaggccaag aatagagcag ttgggaggga 25200 agtttttact gtgtttcttt cttttttttt tttttttttc cttcccttgg acttttccat 25260 ccccactctt ccagattttc ttttttttt cgttagactg atctccctaa cacacctgga 25320 aagatatggg cttatataac acttttctag agacaataaa actcccgatt aattcttttt 25380 tttttgagag atagggtctt gcttatctag gctggagtgc agtggagcaa tcacagctta 25440 ctgcagcctc gaactcctgg gctcaagtga tcctccacct ctgcctcccg agtagctggg 25500 actatatatg tgtggcacca cgcctggcaa tttttttttt catttttttg tagagataga 25560 gtcactctct gtcacccagg ctggagggca gtggcataat cacagctcac tgcctcagcc 25620 ttccaggatc aagtaatttt cttgtctgta tagctgagat gacaggcatg caccactgcg 25680 cccagctaat ttttaaagtt tatttattta tttattcatt cattcatttc attcattcat 25740 tatagagata gggtctcact ttgctgccca ggctgatttc aaactcctgg cttcacgctg 25800 tcctcctgcc tgcacctccc aaagtgctgg gattacaggc gtgagctgca gcacccagca 25860 ctaaattaat tcttgatctg tatatttatt cacatttctg taagatagga atagaagaga 25920 ctgtgaagtt agaatttgac ccacctggca catgttgttg tttataatat taatggttaa 25980 gagcaggaga gttcattttg aatactacct attaaggaca tgatctgcca gtaaaacatc 26040 tccgcacctg agtatgtgtc aatactttgc aaacctaatt taatccccgc ctattttgaa 26100 tttatgataa ttcagctggg ctgccctgaa gttgtttaat gtatgtagaa aagcagatta 26160 atggtgtaaa caagattatt gggagaacac ttaagaaaac aagacttttc aagtactttg 26220 gtagcattca tttacataaa caccctacat gttaattacg attgagtatt atctattcat 26280 taaagcaagc ttgctgggtc tctacttggc aaaagctctg ctcgttttga cagatgctta 26340 aaagtgatcg aaattgcagt tctttttata tgttctatca tttcgaattt gcactaattt 26400 tcttattaca gtgagaaatt tttgtctctg cttttcattt tattaggcag tggaaattgg 26460 aacatttgtg ttacaaatca ggagagctta tcacagaaac aggttacatg gatcaggtat 26520 attttcttct tgttggcaaa aatttctcag gaacacccca gtagtgtgcc ttaacctaac 26580 gcatggcctc ttctttttaa ctttgacaga taatagaata tctttaccct tgtttgatta 26640 ttacaccttt ggactgcttc tgggaagggg cgaaattaca gtctgggaca gcatacctcc 26700 tgtaagtgtg tgatcatgct ttctgatgtc tgtgacttct ctaggactca gtgtttctaa 26760 tgttgcttat cattgtttgt tccatttcag ttttgaacaa gaaataaaaa cattgaaatt 26820 ccatgtgcat tttttgagtg aatagtcggg ggagagggga tttcagcaga atgttttttc 26880 tcttttcaaa aaacaattct gtaggcgtca ttaaatttca ttcactttta ccaacctatt 26940 tatatgcaaa taaaatgcaa attattgcag agtacgtgtg attttttaac tctttaaaat 27000 gttcgtagtt tcgaagacga ggcatttaga cacttatttt ttaaggagag actttattag 27060 tgagtgggtt cacatcagaa tgaaatattt tgagtttgag atcttcctgt gaagtaaaaa 27120 gctaaccttt ctttagatca cactaatggc atttaagggg gaaatccact atctgtgaag 27180 gccacagtag ggaatgtttc accgtttagc agttggatat tatatatacc gcatcattta 27240 gagaataatt gttaatcagc atagacattt tcagttaatt atgcaagagt gagagcttgg 27300 gttattgttt ctgtcctggc ttgcacatat ctgcaaaagc aatttgcagt ggccatcccc 27360 tgaccttcag tgtacagttt tagatgggaa ataaggggtt ttgtgttttc tggttgggag 27420 attccgaata atgacttcag cctggttaag cagctacagt gtggtttgaa ccacataaca 27480 ggcagccaaa agcctttctg gtctgtcaac agcacagatt caaaagtgag tgtgggggga 27540 agtggctgtg atggtggtga tggcagaggc tgcagggggc ttgcccattc cattgccagg 27600 ctgtcagaga gcgctcataa gtatgggatt gttaaaggta gcagagatca aatattttga 27660 ttgatgacat ttacaaagta tttatttggc tgccaagtgc taatttgata ttgtgacgcc 27720 ctctttttta aaaaaaaaaa aatttaattt tggatctgtc tttttggcta attttgtatg 27780 tagatattaa atatacaata tcagcaatta aagattattc agtgccctca ttaacttatg 27840 agtcctctct ctgcttagca tcttcagtca tgaattattt tcctgaccta agtttttatg 27900 cagatatgct ggaaaggagc atttgttttg atgccagagt cccagaactg cagcattgcc 27960 aggaacctcc tacaaggtgg atgcagtggg cgcagccgtg ttactttacg atgcgtttag 28020 aaggctcttt tcatggtctc gtctcctaat ttcttttgca gaggtaaacc tcctttgcgg 28080 tggacaaact tcgacccttt ggaattcctg gaagagttaa agaaaataaa ctatcaagtg 28140 gacagctggg aggaaatgct gaataaggct gaggttggtc atggttacat ggaccgcccc 28200 tgcctcaatc cggccgatcc agactgcccc gccacagccc ccaacaaaaa ttcaaccaaa 28260 gtgagtacca gcagtgagcg ctctcagaag ggtggagagc aaaacacttt tttgtgtcca 28320 ttcatcgttc actttattat tttcattttt aacatttcat tctccatgat cgtctttgtc 28380 tatggaacta agtttattta tagagctaaa ttttgctgta agatttgcca tacacctccc 28440 attagccttg ctattaatgt tctctctgaa acacacaagc ccttaatgca ctggatttta 28500 acaaggcatg tgacctgcct actaattccc ataattatgt ggctgtcttt ttattttagc 28560 ctcttgatat ggcccttgtt ttgaatggtg gatgtcatgg cttatccaga aagtatatgc 28620 actggcagga ggagttgatt gtgggtggca cagtcaagaa cagcactgga aaactcgtca 28680 ggtaagccag ctcccgagga caatctatgc cctgtagtct tcttcctttc ctcaaaagcc 28740 acttccctcc tgacatcggc aagtgtattt gtattaatac ttaaaccgtt atcctcgcta 28800 gccaggtggc gtcatagaat attaagaaat agtagcagac tgcaacagct tgaaaaagca 28860 ccttgtgggg aatttttcaa gaatggattt gtagttttca tcaggaccat agttcctgac 28920 tatagggttt aaggagatct gcccattagg tagagaatgg gagcaggtgt aaagtaggcc 28980 gggacacact ggtcagagag agttggtggt gcgagctgca cagtgtcata gactgttagc 29040 aaaagatgga gagccagcgg ctcaataaga attatccttt gtgcacttgt ggactctggt 29100 cagtcaggtg tctggcgttt cgtgtaagat ttctcccttg ggaacgccac cgtctgggat 29160 ttctgcacag caagtatgcg tcactgagcc cggtgtatct gttcaagcta tctgctcctc 29220 tccccttcct gtttcatgga atggaaactg tgaaaggaaa ttgcctatta atttaatttt 29280 ggggtatatc tgtaaaaggt ttgtaaggtt atacctttaa tatggtacat caatctatta 29340 aataaaataa ccatcctggt cccattttaa tggaaacatg tgctcacaga gaaggaaaag 29400 aattgcagcc agtgagttgg gggagctggc tggggatttg aggcagtgga aactgcttcc 29460 tgggaatact gatgatgtgc cttcccttgg actgtgctgc agcgcccatg ccctgcagac 29520 catgttccag ttaatgactc ccaagcaaat gtacgagcac ttcaaggggt acgagtatgt 29580 ctcacacatc aactggaacg aggacaaagc ggcagccatc ctggaggcct ggcagaggac 29640 atatgtggag gtaaacccac cttcgaatcg gcgtgcagac tcgctggtta tgcaattctt 29700 cattttcacc attatttaaa acatttcttt ccattcgctt tattttcaaa acattgcaat 29760 tctgggaact tgatgggatg aaaacttttt tcctcttctt tgatattgaa aatcctggga 29820 taatatctaa aagactagtt ctaattgggg tgccctgaga catgtttagt aaccagttgt 29880 gaattccaga actaaagcac ataacagtgt ttaaaaaaac acttggttag caaaggtgtc 29940 tggaaaacat tagcaaggca tagaatctgt tcacagctgc aggccccttg gtcaggtcat 30000 gtgacaggag ctggcctttg tttcccaagc agtgacctct actgagctgc atgtgacctt 30060 ttaaaagtgg ccagcaaatg aacaggggga ggagggccat aagaatgagt tgttttggat 30120 tagtggggag ccgatgggac cgcaagtcaa ttgtgaagtt aacggagaag agacgagcag 30180 tctcagccct ggagtaaata cagcactcag agtgaactcc agcgacacca gccctcagca 30240 gcacccactg ccactgatta gccatggccc ttgtcctaaa acagggttct ttaatgttag 30300 cccaacttca gcttctctcc ctgccctgga atcacgtaga acttttttaa aaaatgcatc 30360 agaaaaaaag aagggctgcg ctgtgtcacc tgagatctgt gctgtcgagg cttgtggaag 30420 tgttcattgc atttgggcat ttcgcattct gttgtgacca caggtggttc atcagagtgt 30480 cgcacagaac tccactcaaa aggtgctttc cttcaccacc acgaccctgg acgacatcct 30540 gaaatccttc tctgacgtca gtgtcatccg cgtggccagc ggctacttac tcatggtaac 30600 gctcgatgcc atgctcctgg gggctggagt ttggtttggt tgttttagtc tttacttttc 30660 catgactgct cctgcttctt aactgctctt aacatcgatg tgcatccagg acagagagag 30720 cgtggcttca cagtggttta aaagtggtcg tgtaaagcat ttttcccatt tgccgtttgc 30780 ctacctttga ctcctgtcat tttatgtgac gcccttgatg taaagttttg ttgttgttgg 30840 ataagttctg ccttttgatt tggggtgatg ggtggaggga aacattagaa tcacaacaca 30900 ttctaatgtt cggcttttgt tctgtgcccc cattgttctg cttgcagctc gcctatgcct 30960 gtctaaccat gctgcgctgg gactgctcca agtcccaggg tgccgtgggg ctggctggcg 31020 tcctgctggt tgcactgtca gtggctgcag gactgggcct gtgctcattg atcggaattt 31080 cctttaacgc tgcaacaact caggtactaa aggagccatt tatctgctgt ccgttgacaa 31140 atgccacccg gcccccaggc ttggcccagc cagcctcctg tgtgctgtgt gtccttctca 31200 ccggaagggt cttgcagcct tttccactag gatgctactg gtttcagggg aatgctgtct 31260 cttgatgctg tccgccctca gggaagtggg taggaagtct gttgggctta ttggttagta 31320 gagacacttg gctgatagga atgtatgtca ttgaccaggg ttgtggctct tcagctctgg 31380 tgggcatttg catggcttgc agggcttgtg aaagctccga ttgccaggcc ccacccccag 31440 agtttctcag taagtctggg gccggggctg agaatgtgca cttcagggca attcccagtg 31500 atgctggtcc atgggccaca ctctgccaat cattgcttaa atgagttgga ttccttctca 31560 tttactagct taaaaaatga tagtacactg actttcgaag tagaaacgtg caggatctcc 31620 tgtgagctga aatggctagg ctttgggacg tcaagtgaat tcttcaccat gaggttacgg 31680 aagccctgct tcaggagctg ttaggtgctg gtggcagagt cctaactagc tttagaatca 31740 tctgaattgc atctcgcatg tctaatgcca ccatcctctg tttttgctgt aggttttgcc 31800 atttctcgct cttggtgttg gtgtggatga tgtttttctt ctggcccacg ccttcagtga 31860 aacaggacag aataaaagaa tcccttttga ggtaatgcaa aaacaaaaga agagagcttt 31920 ggggacatca cagcttcctc tgttcctaag tatttgtcct ttaattttcc tcagtctgac 31980 ccagtaaaga tttcagtccc atgtcagatg atgtgtcact ggctgccagt caatgaaata 32040 agctggaaga ctctcaggac atgtatttgc tatgagaagt cccaagagct gcatctcggg 32100 tgcctttagg aatacgggtg tttgttttaa tgtgacactt tatccctaac tgccatacat 32160 tcccagagcc tgcatttgct tctctggaga tgtctgtcac ttagccatca cctccctcca 32220 ctccctttta aaattatact taagcgttaa gtcattatct tgcagctttc ttctctggat 32280 ggtaataacc atgaagaatt gatgactctg tagatggtac tgaataatgc tggtgttagg 32340 gggtaaggca ggtggctctg tttccctaat gccagcatga taagctgtaa taacagttgt 32400 gttattctgc cacgtatctg ctcacacagt ctgtgctcca aggggaccat gtccagtgca 32460 gctctcagcg ctgtgttttt ttattcccag gacaggaccg gggagtgcct gaagcgcaca 32520 ggagccagcg tggccctcac gtccatcagc aatgtcacag ccttcttcat ggccgcgtta 32580 atcccaattc ccgctctgcg ggcgttctcc ctccaggtga gcttctggtg atgaaggctg 32640 tggtgatcct gaacggggca ctgacttcca gcatcccatg tctgcggtct ctgctaaggc 32700 acttcagtta cttatgaagt gaaatagaaa tgcctgtgtt tgaggctctg tttaactggg 32760 tggatgctgc tttaagctta taaccctgac actccctcta aaaaactaag cccttctgga 32820 gtttttcctt cctttctagc cctatgaagc ccagacgtct gttgccttat agagtggcca 32880 tgtcctttat gcatggcttt cggggctact ccatgttgcc ctctggggtc accagcgctg 32940 cagccagctt ctgggccatc ccctgcttcc aaacaccact cccagtacct gcacttaccc 33000 cctctcccgc tgcccacttg atcccaaaca ggctaccttt tctttcgctt ttgccaaagc 33060 acccccaacc caagacagta ttaagctgag gtcgcatgtc agacggcact gcaggaccgc 33120 gaactggcga ggctctgtgg agaatttcct gcagggtccg cctcggtggg ccctttcttt 33180 ccacctccct ttcctaagtt ggccgccaca atctttcctg tcccctcttt tctttccttt 33240 tggtcccctg ctcccctctc aggctgccca agcagactca tgatccctct caccttccca 33300 tgcagagcac gtgggcccct cgtgacttgt cctctccttc cagaccaggc cccgtcaccc 33360 ccagaggccg tcagggtatt ttctaatcca gactcagctt ctgtgaattg taagcatgga 33420 cagttccctg ggatggggat agagctgtag tccgttctgc gcctggagta aattactgac 33480 gttgcccttg agctacctga aattcatagg aatcctaaaa ttagttactg cagccagtaa 33540 agcagagact tcaccagttt gtgccatggt cttcctgagc gcaaagtggc ctggagtttt 33600 gatatctcaa gatgttgtgg gggttttgtg aattaatttc aaatttcaaa acctcaattg 33660 tttccccttt ctttctctgt gatgatatga tgtctaattc tcaagctggc caggttgtta 33720 aaggaaatga cttctgtgtc actttttcac ttgttgttag gatgcccggc acactcacac 33780 agctttactc tactcaccaa gagttcctgc agatgcgagc aggaagagaa attgaccagt 33840 cttgcatctg gtttctgttt atattttgtc aatatgttta gctctttcct agtctttcca 33900 tttgtcatgt aagaggaacc aatcaatcac gtatttgaat gtcatttcgc tagtaaccaa 33960 gaggcctggg caactactga tcctactggg tttgggaatg gaggcatctt tagtatttag 34020 tgtgaggcac agctggagaa aagattctat gccaattacc gtaaccgcca gccccaaaag 34080 aaacataaaa agaaaagaaa acagggttta tttatattat aaatttatat agaagtaaaa 34140 atagtgaatc aatgaataac gttcagatct gatgctcgaa ccaaagcaca ggacaaggaa 34200 actctctctg attgctcagt ggcatgaaag gtgaaccaga ctcgcagtgc agctgaagtt 34260 gtagaatgcc tttgtgcgca ggtgtgtgtc tgctcagcac cctgtggtac cccagtctca 34320 tttcacgtgc agccggtgct ggtattgaga aactgttcta gagtctttta gtcatgggac 34380 cctgtctgcc cattctctct cctctcccct tcttttctgc ttgccttttt gctcactgtc 34440 tttctgtatc tgctcatact ccttcttttc ttcttttctc tctcattctc tcctctcctc 34500 tcttagtaca tactgatggc tcatcgaggc cgactctcct ttaatgatac cctgtggtgt 34560 ggtggtctga aaagctacat gaggtttcct tacgaggagt agccttgtag aaaatccagt 34620 gcgctaaatt ctcccaaggt aagcacctta cagagacaaa aatgagtact gttggttttt 34680 gtgtttctgt ttcaaagcac cacagtatca ctgtagaaaa ttgcaactat agcttccaag 34740 agtcctcatc ttactgaaga atacctcctc atgacactgg ttaattctct gtcaaaagaa 34800 aaaaggagtg cttcgcacgg tggctcacgc ctgtaatccc agcactttgg gaggccgaga 34860 cgggtggatc acgaggtcag gagatcgaga ccatcctggc caacatggtg aaaccccgtc 34920 tctactaaaa atacaaaatt tgccgggcgc ggtggctcac gcctgtaatc ccagctactc 34980 gggaggctga ggcaggagaa tcgcttgaac ccgggaggcg gaggttgcgg tgagctgaga 35040 tcgtgctatt gcactccagc ctgggtgaca gaacaagact ctgtctcaaa aaaaaaaaaa 35100 aaaaaaatag gatagaaaat gcaaagaaaa gagagagtgt gcaatgattt ttgcagtggc 35160 catcagaaaa ttttccctgg ttctctttta aatgtattga ccctcaaaat tggccattat 35220 gtagcttctc tttccattga tgaacagtat caggtttgac tctgggtgtt cagttgtgtt 35280 tatatttgca agatgctaca gattaaacat caaaagggag tgacccaagg cggttctgtc 35340 caatagtaaa cctgcgttac cttcagaatt ttccatataa aactcctcca attttgtagc 35400 ctgaccaaat aattagatat ttttttccac aaggaaactg tcttaaacct catcagcctt 35460 tatccatctg cctaaatgcc atctctacac cagaaatcac tggcatcagc tgtaattctt 35520 tgtaattaac tagggcttgc tggtagccca gtagtgttta ttcttcaatg aaaactcaca 35580 gaacagaacc ccttgttgtt ctgtctggtc taggagggtt caagtggaac ctcctctgca 35640 tgtgtcccag ccttagctgc tttgagggga tggggcattt cctatgagta caataactag 35700 aattgattca cagttgcagt atcatcccca tcatcttctc tggtttactt acactctctt 35760 gcctttgcga caacccttct tgctttctga gcagcccttg ctggttgttt tactattttg 35820 gtgtacacct ggggacctgg cactgagaaa atactccgcc atacatgtag taggttatga 35880 gaaagtcagt aagatgggac gctgcttggg gttcttccct catcccttca tttccgtcat 35940 ggacacggag caaggtgccc agcaggcttc tctgaccgat gaggccggct ggtgcccatg 36000 cctgtgcccg tggggctccc tgtgtcacga acctctgctc tcctcatcct catgaacacc 36060 tgtccaaatt gggatgccca gggtctcttc tctacattcc actcctccat tctaaacatg 36120 actgatttta aaagctaaaa ggattcggcc cccaggatga catctggaaa atctccgtta 36180 gaatcctacc tgttcttcct gccatcccct gctgtctcac ggtcaggtgt cctaaccccg 36240 tccacagacg tcctctcagt aagggaccag atctcacaaa actcccggtt ctcagctgag 36300 ctaggggctt ggcatcaagt ctttgtttga tctgatttac tggataacct caggcaggtg 36360 acttgaccgc acttcgggga ctttatcagg taatactgtc aagagcagtg agaacctcct 36420 gtttgctatg aatcaggtat gaacgatctg atcttcatag cttctccttt ctcttcccca 36480 aagtgaattt caaaccccag cagtactgag gtgcttgagc caggtgtctc ctcttgcaca 36540 ctctgtgttt ttttcacagg gagcacctgc cattcccctg ctcctgactg atctcttttg 36600 cttttctttt ttgagacgga gtctcactct tgttgcccag gctggagtgc aatggtgcga 36660 tctcggctca ccacaacttc tgcctcctgg gttcaagcag ttctcctgcc tcagcctccc 36720 gagtagctgg gattacaggc atgcgccacc acgcctggct aactttgtgt ttttagtaga 36780 gatgggtttc tccatgttgg tcaggctggt ctcgaactcc aacctcaggt gatctgcccg 36840 cctcggcctc ccacagtgct gggattacag gcatgagcca ctgtgcccgg ccctcttttt 36900 catcttataa accctgctga agcctctccc gggaagcctg ccttgactga ccacccctcc 36960 accccactga gctgctctgc agcctgacac ctgccttcat gacgccatcc atcattcgag 37020 attgtcattt gtgtataggt ctggctctgt gagaattgag agtaggattt tgtcttattt 37080 atctttgtgt ctccagcacc cagcacagta ctagactttt ctttttaaaa gatctctctc 37140 tttctcaggt aaattctctt gtcacagtgg tgatgagctt atttgtgtag gtctatcaga 37200 caggtcttaa atacattaga gtggtaagct aacatgcttc atatttttca gttgatgaag 37260 gattttcaag atagaccaag aagaaagagg ttaggtagtt tttagaagaa cgctcttgag 37320 agggaattaa ttattggaag acatctctcc ggaactcagg cttgctggtt caccttcagc 37380 ataaactcac aattcccatc caaagccctt tgtggaagtt ctccctggat tgtgttaggt 37440 ggcagttata gccaggtttt ctttcctcac cctaggacgt ttatcagttt gagatttgtg 37500 aactaagcag ttctttgaga agcctcgttt tttattttct ttctttcttt ctttcttttt 37560 tttttttgag acagactctc actctgtcac ccaggctgga gtgcagtggt gcaatcttgg 37620 ctcactgcaa cctccatctc ccaggttcaa gcaattctcc tgcctcagcc tcccaagtag 37680 ctgggactac aggcatgtgc caccacactc aactaatttt ttgtgtgttt ttagtagaga 37740 cggggtttca ccgtgttagc caggatagtc ttgatcagga gatccctgac cccgtgatcc 37800 acccacctca gcctcgcaaa gtgctgggat tataggcgtg agccaccgcg cctggcctcg 37860 ttttttattt tcaaagccat gtctggcaat ttcctggctc ctcagcattg ccagtgcttt 37920 tctctgtggt gccccttctg ccgtgccctt ccgagctggg tcgacttcca ccggcttctg 37980 ttggcttccc ctattaacag cccaattttg taatttttac taggtcagca gaagatttgc 38040 caacgcactg cagaatttag ccctgtgttt attctaggtt atggagtgac ttttgaatct 38100 gtacttattt attctgcgta ctataatcac acacaggaat ttctttctgc ttaactctcc 38160 ttgacctttt atgtttcttg ctctcacacc ccacaggcta ctccagaggc aatttggaat 38220 gtgcctatta aaacctcagg ggacacgtgt gaaattgtat ttcacgtttt aaagggggac 38280 attttgatat actcgatcca ctttatataa aaatgtttaa ctgtaaaatc agggtcgcgt 38340 gacctcttgg aagcattctg gaagggaact gcttctgttt gttttaaatt ctatctcgag 38400 tgtgctctct gttctgcctt tgtggatttg gtttggttag gttactagca acacgttagt 38460 agtttagttc ccaggtttgt gccttatcgg tttatggaat tattagagat agaaaggccc 38520 agaaacagtc aagactattc ctatcaaata ggctcttgat gatgtagcaa aagaaactct 38580 taacatctgt cacggtttca aatgcttcaa gaggaaaggg aaagaaaaat attgtttaaa 38640 agcatcttta ttttcgaagc agtcctctga ttgggcggag gcatgttggt gacctctgaa 38700 ttttttttct gctcccaggc agcggtagta gtggtgttca attttgccat ggttctgctc 38760 atttttcctg caattctcag catggattta tatcgacgcg aggacaggag actggatatt 38820 ttctgctgtt ttacaaggta cattttcaga ctgctgtggc cttttgattg ggtgcagaat 38880 ggtgctgtga gagaactctt tcagcctgtg gacttataaa ggaatgtggg taacggggtt 38940 tgtgctggtg tggagaacgt aggggagaga ttggacagag gctgcttccc tagggggaca 39000 tcagagtccc tgggcttcct tctcccctgc cgcagctgaa cagtctcaca gccctcaaga 39060 tgctggttcc gatgacccct ttttccatca tgaactgatg ttgccgattg taggaatgtt 39120 tcatatctct gcattagagc agaacaagat tgaaaaacac ccatctagaa aatatatagt 39180 cctttgatgg tggtttggtt ttgtttggaa ttgtgctttg aaggattcat catcatggaa 39240 cttgcttttg aaagccaaat ttaggatcag tcctccatgt ggcctcctca gactgacttt 39300 tatctagttc accaggcgat gaaccaggtg atgttatcaa ccaggcgatg tttctggaat 39360 tcagcaatgt gatgtttctc tcctaagtca gagctgtgta aaatgggtat tctccgtaca 39420 cagtgaaaaa tggcagaatg aaagcaccat ttccctgttt cagcataaca ttgcaacatg 39480 tttcccctcc tttcagcccc tgcgtcagca gagtgattca ggttgaacct caggcctaca 39540 ccgacacaca cgacaatacc cgctacagcc ccccacctcc ctacagcagc cacagctttg 39600 cccatgaaac gcagattacc atgcagtcca ctgtccagct ccgcacggag tacgaccccc 39660 acacgcacgt gtactacacc accgctgagc cgcgctccga gatctctgtg cagcccgtca 39720 ccgtgacaca ggacaccctc agctgccaga gcccagagag caccagctcc acaagggacc 39780 tgctctccca gttctccgac tccagcctcc actgcctcga gcccccctgt acgaagtgga 39840 cactctcatc ttttgctgag aagcactatg ctcctttcct cttgaaacca aaagccaagg 39900 taatctgcca caacttaagg ctcttcctgt cttcaaaaaa ataacagaac ctttggagtt 39960 catcagattg cttctacttt tcttcttttt ccttaaaaaa aaaaaaattt cgtttaagta 40020 tgatacattt cagtcctcca aaagtcaatg cttttagagc atagggccat tttaatgagg 40080 tcatcttcca tgggagtgaa cctctatgca gcaagtcttt ttatgaatga ggttgtttaa 40140 aaatgtgatt attgccactt gcggtggctc atgcctgtta acccagcgct ttgggaggct 40200 gaggtaggag gattgtttga gccaggagtt cgagaacagc ctaggcaaca aaggccaacc 40260 ctgtctctac aaaatatttt aaaaattagc cagggacagg tgtggtggct cacgcctgta 40320 atcccagcac tctgggaggc caaggccagc ggattgcttg aacccaggag ttcgagaaca 40380 gcccaggcaa catgatgaaa ctccatctct acaaaaaatt gcctgggcat ggtgatgtgc 40440 ctatagtccc agctgcttag gaggctgagg tgggagggtc actgagccca gggagtcgag 40500 gctacagtga gccgtgatgg tgccacttca ttcaagcctg ggtgacagag taagaccctg 40560 tctcaaaaga gagggggaaa aaaggcatgg tgctgtgtac ctgtagtcct agctacttgg 40620 gcagctgaga caggaggatc atttgagccc aggagttgga ggcaacagtg agccctgatc 40680 atgccactgc actccatcct gggagacaga gtgagatccc aactcagata cataacaaaa 40740 caaggctggg catggtggct cacgcctgta atcccagcac ttggggaggc cgaggtgggt 40800 ggatcacctg aggtcaggag ttcaagacca gcctggccaa catggtgaaa ccctgtctct 40860 actaaaaata caaaaaaaaa tagccaggcg tggtggtgca cacctgtaat cccagctact 40920 tgggaggctg aggcacgaga attgcttgaa cctgggaggt ggaggttaca gtgagccgag 40980 atggcaccac tgcactccag ccttggcaac acaagactgt ctcaaaaaat tatatataaa 41040 acaaaacaaa ataaaaatgc gattactatg attttatcct ttttcctatg ggagaacaac 41100 ccctacaaga taaatcagtt taagtgtggt ggtgaaaaca aggtattaac tagacagctt 41160 ctctttgtcc aggaagagtc agtggtgctc cctggggtct gaccttgtgc ctcttctgtt 41220 ccaggtagtg gtgatcttcc tttttctggg cttgctgggg gtcagccttt atggcaccac 41280 ccgagtgaga gacgggctgg accttacgga cattgtacct cgggaaacca gagaatatga 41340 ctttattgct gcacaattca aatacttttc tttctacaac atgtatatag tcacccagaa 41400 agcagactac ccgaatatcc agcacttact tacgaccta cacagagtt tcagtaacgt 41460 gaagtatgtc atgttggaag aaaacaaaca gcttcccaaa atgtggctgc actacttcag 41520 agactggctt cagggtaaga cggcgtggga ggctctcgtc ctttcggtct tttgcgtgtt 41580 cagcttcaac aggttccttt gtcatgatta tgagagcgtt agattagaat gtaacactga 41640 cgtgtttcat ggacttttaa gagttgctca agattcttac atgaactgtt tctgcagcag 41700 cctcccagat ctggctttta cctataaaat gatgcagata attcagatga gcttctgtga 41760 gaatgtacaa gtgcacgtca ggaaaagggg agcatgttgt aacaggtgga gccgaggctt 41820 ctggtgctct ttcctcttgg atagacggtg gctagtttgg tgaccacata aaatcaaagt 41880 gcggctggga tttccagact gattgccaaa ttatagctta ctgcaccagg agatgctaga 41940 taagcagtgg acatagtctt acactccata ttttgaccat ctctttaaaa attatctatt 42000 tctaattgac tttgttttta gagcagtttt aggttcccag gaaaattgag cagaaggtgc 42060 tgagatggcc catatccccc ttcctcaccc acacacagcc ccctcgactg taaacatccc 42120 gcaccagagg gatgcatttg ttacagctga tgaacctgca cattattacc caggctccat 42180 agtttacggt tgggttcatt ttgaccattt tttgatttgg tacttgaagt aaagttataa 42240 atgcttagta acatttcaca ttattttata aataattaaa ttctgtttta aaatgccttt 42300 cttggtgggg cacagtggct cacgcctgta atcccagcac tttgggatgc caaggcgggc 42360 agatcacctg aggtcaggag ttcgagacca gcctggccta ctagtgaaac cagctctcta 42420 ctaaaaatac aaaaattagc tgggcgtgct ggtgggtgcc tgtaattcca gctactcagg 42480 aaactgaggc aggagaatcg cttgaacctg ggaggtggag gttgcggtga gcctagattg 42540 tgccattgca ttccagcctg ggcgacaaga gcgagactcc atctccaaaa ataataaata 42600 aataacagtg cctttattgg cttcttcact cttagaaatg tttctaggaa atattcatca 42660 gctggagggg aaaaaaaagt ctaaattttc tcctgaccga ctgcacgtaa atgtatgcag 42720 tgattccagg aacatctgtt catttattct gcattgacac atgcaaagcc aagtagagaa 42780 tcaggataat tatccaccca attcaagcaa aacactttta ctggagtacc aaatcattat 42840 ggcccccaac attttttggc ttggattatc caaatgattg tcttaatttc ccacttaatt 42900 aggcttgttt aaacacagat gtaagtgcct tttttggtct gaagtcaata cacttgtatg 42960 taaagactca gcagccagtt tccctgagag tttgcaggaa atggtcaaca acttgaggtt 43020 ggtagaggat ggttccatac agcttctggc cttgacttgt gtttaccaga actttgtgtc 43080 tacatgtaca cccaatttga ctttcctttt ggaggaaggt acagagaaca tgccatgatt 43140 attatttatt aacaccctcc tgagacgaac gtgaatttgt tccaagtttt atttttcaca 43200 tttagtttag aaagcaatgg tttttgggat aatgagttaa aagagagaca gtggagagag 43260 tccctgcttt cattttcccc ccattgacca aagacatata aataacttgc cacaaatgac 43320 aaagagatct gctgtgccct gccagtctgt gagcagagaa gggttattgt agagtgtatt 43380 tcagtgtctt tggccattgc tctggaggct caatgtggca tgttaggcag ggattgggaa 43440 gggggtaaag ggggattgtc tcgaggcagt gcaaagggtt aaccttttta tagagcattg 43500 tagatcatct ctatacgttt cttcctttat agatgtaaat cagctggagt tgagtttttt 43560 tttttaaggt gcatttgaat catgttttga ttgctgtgtg aacagcatac acctagacca 43620 agtgagatcc attggtgcta agcaatcagg gtcccaggca gccctgggac tccatgactg 43680 actcttacag ggtccgctag agcactcaac acagaatgac cagacactgg agccctttgc 43740 tgcctacacg tttttcaggc ctgttgaatg gttgatgtgg tgtttgaaca ttttctacaa 43800 ggaaacaatt atccttgagt cagctttcct tgctgacatt tttgtgtggc ttttaaatgg 43860 tgggagcctc attggttttt aatggaattc ccattaaaac tatgtcatct cattggtctt 43920 tatcgacatt acaatagttt gtctttgatt ttttttactc ctaaaactat ataatggtta 43980 atttcaaaac tatcccacat gtcacatctt aaaacataca tgcaaataag gcagagtcag 44040 ataaaaacca tgcctcgagt catgtacaaa tgtgttcatt tttatttcac actggattat 44100 gcaaacaaaa ttttgattaa cattttactt ctagggtccc atagctgaag gaaaatgggc 44160 aattggggtt attcctttgg cctagaactt tacattagaa aataattatt gacacaaaat 44220 attcataaga ggagaacttc tagctaagat attaaggttt gctgtaaaat aagtaaaaag 44280 tcacaatttt ctagagtgtg catgcattgg aatatgaagc actggctaaa gggcagtgga 44340 aacccaacct tatcccttgt tttgtatcca gggtcgtacc ttgtacatgt gcttaggcca 44400 gccccttgtt acttgagctt tttggtgatt agtcagaaaa tactgtagta atggggaaag 44460 aacttaactg ttccagaaag tcgatgactg tttcgtattc atctttgaac ccccagtaga 44520 gtgaatggca cctaagtgac cagcagtgtg gattctgagt tgaatcgagt ttccagcaag 44580 gctgacctcc ccagatagga tctttcttcc tttgtttcac cctcgggtgt cccagaagtc 44640 tttgtgtgtg aatatcataa aaccgccccc agattttggg gaccccgttt gccaccagat 44700 gttattgatg ctggagttga acctgcttgt cttactcctg cctttgacac atccttgggt 44760 accacggtgt gtccccgcac tgtaggccag tgagtggctc cagctgcctc tggtgacttg 44820 ctgcctgggt ttgagctcca tccaacactc acctgctggg tggccccctc cagtctcccc 44880 tttccaagac tcagttcctc catctgtgaa gccggagtga ttaactctaa cggggctgtc 44940 ccttggttgc cgtgggatgc ccagcgccac cccacactca ccaagtgtga gcctctcttc 45000 aggattagct ggttaaggga gaggggctta aagcccagga cacgtcatga catcatgaaa 45060 attgttacag cgaggaaaac agacgaggcc tccctttttg aggggaaagg aggcgcagta 45120 atttttcttc tgctgtttat tgtttttcaa aaacagaaag aaagggcttt cagtaataaa 45180 ataacatctg ctcagtaccc tgtgtgtgca tgcctcccta tgaaaacccg tctgtctgag 45240 aggtgcacgg cccacccggt ggtctcctgt cccgtctccc ctccacgctc accctgacac 45300 agactccttt caccaccgag cccactgtca tccccaaatt gttcctctag ccagtagtgt 45360 cagaaggagg gtttcgcttc ttagagagac agaagggggc ctgtgctccc cctccctccc 45420 cacacttcag accccaagag cttaaccatt ctgagcacta acgcaaccag attttttttg 45480 aagcctttga aatcatccaa ggcatgtccc gaaatgaaat aaacgcttct cccttcttac 45540 tagccgtgtc caacccatac atgtacagct tgttcaaaag ctgtggtttc ctgagctgct 45600 ggggcttggg agctctactt gggaggtggc tgggaggggc aagggtgggt ggggggaggg 45660 gggtgtcccg gagagcgtgc gcaccagcca gcgctcagac cctaaggccg ggtcaccggg 45720 gccctgtttt ctcttccaac atgcttatct ctttacagct gcagccaaac cgtcaggtct 45780 gtaatgatgg ttttgattac tgaggccaag cgcagctgtg tgtggtgtgc tggcgggctc 45840 gcccatcccc caggcccaga aagctctttc ctccccctcc ccggcttgtg gtttgtcatc 45900 tgttctcaca gagcctcctt gtattggcct gtggcttcct gttctcaatc ggatccaaat 45960 ttaccctgtg aggtatttcc ctgcgtgcac acgagcgcct tcccttcctt ctcctccacc 46020 ccctctcctg aggaagggtg gcagagagga agagagcagt cgagagtgaa taggtgttgg 46080 ctgtgatctt tacacaacct ggcagcggat cccacagctt gtgttagctc cacaagtcga 46140 acagatggaa caaattgaca gaatcgtgtt cgctcaccct gggctccaga agcagctgag 46200 ctgctgtttg aagttggggg agtttgaatg tgctttttcc cctctgtgtg gaatttctgg 46260 ttgtattgaa gaactcatga cttagcaccc cgagtggcac gaaacggtta atgaccctgg 46320 tgcgtgtctt tccgtcgcac tcttgccttc ttttgtaatt gtcatggggc gaaaggagga 46380 gagtggtttt tcttaagata aaatatgagt atttgtttca tagaaacaga taatctcctt 46440 cccccctttt gagcagtggc tggcagcagc tgcagttcat tcatgaaaga tccagtgctt 46500 tcagtcaaag tggatgtggg acacagaggg tgtgtttctg atggacgtct aagagccccc 46560 tgccctgctc agtctcctca gccccaccccg ctaggaccag ggtccttctg gctgcgagtt 46620 ataatgtgtt acaatcattt gccatttcta ggacttcagg atgcatttga cagtgactgg 46680 gaaaccggga aaatcatgcc aaacaattac aagaatggat cagacgatgg agtccttgcc 46740 tacaaactcc tggtgcaaac cggcagccgc gataagccca tcgacatcag ccaggtactc 46800 cagctgctgg gcactgaggg cgcttccagg gctgcggggc cgctgccctg gtggaggctg 46860 cttgacagcg tgtgacccca ccctgtgctc tctggagacc taaggcactg ggagctggta 46920 gaaagaatat tgggtgactc taattcacct cctcccacca gctaattgtg tgacctcagg 46980 ccagccagtg cacctcactt tcctcatctg tcaaatggga caggcgtgtt cctaccacca 47040 gaacaattgt cagaataaag tgcagccaag agagtgcagg ctctttccaa tgttagaaat 47100 gcagcggcgt gtgattcttt cagttctagg actcggtacc ttgttggtct tgatggtatt 47160 caagcttgga aagatggatt tcttgggtag cagtcatttg gatgagcaga atttggggta 47220 ggtgggtggg ttaggagatt ggagaggtga cagaaggatg ggaagatttg ttacatttga 47280 gatctttggg tggccctggc cccaggagta gacagatcgc tctgtgatga gtgaagcaaa 47340 cggaaatgtg cacccttgga atcagagtgg ctgcgccatt ctgctcactc ctgcagtaat 47400 aaccgtttct gtttgggaat catattctcc acttgtgttt gcatcttctt gctgccattt 47460 ggattccagc ataccccttt tggttctgca ggtgtgttca ggagtgtgtt ttggactcct 47520 ccaattgcac ggggcccggg ctacctcagc ttcctcggag cctcttccct tggctctttg 47580 tagcttgctt gcttcacctt caggcagaaa accgtcatgc taatgatctt ctcagcagct 47640 atgtttattg tctccccttt tttgctggca ttcaaggtga cagatttaca aagtacattg 47700 ttcagagttg ttatggagtg tgaaactctg agctcacagc agcaggcagc agaccatcac 47760 gtttcccaag gatgcaggca gaggagtctg cctcagagac accaggaaag tgcccaggca 47820 gcagggctgg gcgagggacc agggatactg tgggacaaat gggattgggc cagaccccca 47880 gataccattt cctcctcccg ggagggagaa aggcgtgctg catgcacaga ggccacgggc 47940 tgcgctgttt gattccaggg atgtgttgag gacatgcagt tgttacatat cctgtggatt 48000 aattgaatcc agatccccga aatccagttc tctcactctc tccctgctcc ttcttccttc 48060 actccttctc taggagccgc tgtcactggt gtttttcatt ttgtttaaaa aagacccaaa 48120 gcgaggaatg aggcctgaat ctaaaataaa caggaaacgg aatttttcta tgtatataaa 48180 acgtacaaac acatactgag tcccacagag ttccccacct cagcaaagcc cacaagccct 48240 cctgccgagg gagcacattt ggccacgcag aggacgcggc gtgcggagta ctacgacctc 48300 cgggaataag atcacctggc gaggcttgag ggtgtgcact cgtcccttgc actttctggc 48360 gctgggcatt ttttgaatcc acaggtcata ggaggctagt gttagcaaaa tttatacaga 48420 tgttgtttta tttttatagc tctcctccat ttactgggtg gcatttcctt cagtgttaac 48480 aacagaggtt aactgcacac agacgtgcat ggggattctt gccaggtttc tcccccttcc 48540 cctcctataa atatgtttct ccagattgtt cattctctgc cttggctgca gacggtcttt 48600 tagcattcag atttaattgg ttcagccaat tcctgggcca tctgcagaac tgtgtttgtt 48660 ataaacacgc cagtgattgc atcctccgat aagtgcacat tgaaagaaat caaaggtgtt 48720 ctgatgggat tttcgacact ttcaacagta ggcattctat tctttgttgt aatgctgtgc 48780 gaagctcagc ttctgtgctc tcaaggcaga agtgtgttta cccccaaccc cattctcaaa 48840 ggcctctgtt cttcccgttt ttgtagttga ctaaacagcg tctggtggat gcagatggca 48900 tcattaatcc cagcgctttc tacatctacc tgacggcttg ggtcagcaac gaccccgtcg 48960 cgtatgctgc ctcccaggcc aacatccggc cacaccgacc agaatgggtc cacgacaaag 49020 ccgactacat gcctgaaaca aggctgagaa gtaagtagcg ttttatcggg aggtctggga 49080 acttacagag gtgccttccc tggttctcca aactcagcaa cagccttcat ccgttgacgc 49140 tacccagggt tcagaagtgt aaacagaaca atctatttct tctcgtttaa aactctggga 49200 gacgaggatg tgtaatggga tacaaccccc gcactctatc acatgggaa atcagtgtct 49260 cgtctccatt cgtagcttta atgctaagac gttcattagg cgttgctctc acgtgccagc 49320 tgttccctgt gaacaccggg gacgcctcca ggttaagtgt tattttaacta ttgcagagtt 49380 ttatcgctgg ggattatatg tttatcttaa ctttgtcaac tctggtgttg aagggatttt 49440 tggcacattg ggtcattcct ataagccacc aagcacctgc actgtgtcaa agctgtttaa 49500 accggagcag aaaagtctgt atacaacagc gtcctcttcc tttcacctct cagcccagag 49560 tttgaaaggt ggttctgtgt ggatttcatt tgcatttctg gtggagatat tagtagcgta 49620 tgctttggat accgggccaa gggaggatgt gagaaagaag acgggtcccc ttgcaaacat 49680 ggctggagac tcagcgagta gtgcttcccc ggatccagtg ctgcccagag ccctgtggca 49740 ggcagccaag gcttgtctta atgaaaattt atagttgaga ttataatagg gcaaatcatg 49800 tttagcaagt caactgaatg accccagagg gtctggaaca cacaacggca gtaactaaat 49860 gcttgttgtg taaggatttc ttcccctgtt gctgaagact tagcattgca ttagaaaaga 49920 agcatacaag gttgaagttt gttcaggcac taaaaggata agttaagcat ttttctcagg 49980 aaagcatgac tcttgagttc ttttgctctt gcaagtgatt gaataaaact gtgtgaactt 50040 ggtattttca tatgtgtcaa gggaacaaaa aaatgttccc aaaatgtaag cctggagttt 50100 ttagacccct cacaaagaat gactgctgga agattaaaat caaatcttaa aaaatacaca 50160 catcacagag ttaaacattt ttaaaccaaa tgggaagatc gtaaaggcct ggaggctatg 50220 atcagcattg tttgttcttt gtatcatgta gaagagcagt cagtaagctt tcatgcaaag 50280 ttcttctctc tttccattga aactgtgatg ctcttctacc ctgggctgct cctaacctgt 50340 gcccttctct gtccagtccc ggcagcagag cccatcgagt atgcccagtt ccctttctac 50400 ctcaacggct tgcgggacac ctcagacttt gtggaggcaa ttgaaaaagt aaggaccatc 50460 tgcagcaact atacgagcct ggggctgtcc agttacccca acggctaccc cttcctcttc 50520 tgggagcagt acatcggcct ccgccactgg ctgctgctgt tcatcagcgt ggtgttggcc 50580 tgcacattcc tcgtgtgcgc tgtcttcctt ctgaacccct ggacggccgg gatcattgtg 50640 agtgtattat aaggggcttt gtggaagtca aattcctttc agcatagctc tttctgcagc 50700 cgggaagttt tgtttatgtc tgggcctctg gaggagggta tagcttgcat catccgtaat 50760 atgtttattc tactcgaggt ggtgaggtcc atggttaagg tagaacctct aatggcctta 50820 ttcgtaggtc ctctctcctg tagcttgaag atttttgtgg aaagataggg gactttttaa 50880 agcacacctt ccatcacagc tctgaacatt tattaaatca aaacactcaa agcctagctc 50940 attttttctt taattgaaaa gtgtcatttt gtgacctcat ccaggcctaa taacgacata 51000 gcaggttctt ctgcatttaa catgaaggga caatcagaga agttaggaga gtgatatatg 51060 gagaaaatga ttttgtgtgt tttaagtcct gggggaaaat gataaactaa tattacgaac 51120 ctgttttttg gcatcccttc tccaaaatac tctcagattt tgatgtaagt ttcatgtaga 51180 gtctaataaa accgtggcaa tgtttaaatt ctgtgaacta tggtatagcc tttaaaatgc 51240 caaaattata aaaacaaagg ccagattttg tgtctgcacc gtgagtctgt gcagcaggta 51300 cattaaaagg taaatgttta gtctgtgaga gttttcatgg cacttagcaa ttgatgttgt 51360 ccatctttca tcattccttc ccctccctcc acctctgccc accacccacc cccagagaag 51420 aaagatcatt tttctccttc tcttccatct ggtaacttgt tgtttatttg tatcttctcc 51480 gctttggacc aagaaactcc aaatctaact cacagatttt atttccattt ccccacaaat 51540 ttttacaagg aagatgaaag gcaagaagct tttccttgga ttttaacagt tggctcagtc 51600 caccccagct gtccccagct cttcaaagtg cagggctcct gtaacctgac agcgtcagct 51660 gatgacgacc tccccgctta cctggccccc acatcatctt tgcttagcct gcaggttcac 51720 tcacaaaagc aaaactactt tgacctgcaa atcttttatt caccccgtcc tatcagcttt 51780 ctttagaatg gagagtgagg caaccaaaaa cttaatgatg ggttcacgga tggtctctgg 51840 cggctgagac ccaagcagga ggagagatgg gtcttgttgt aaactgtgaa attcgcagct 51900 aagtgatgcg gccatgcttg tgcaattcct cgtggattgc gctggtggag ttgttctgta 51960 tgttttttgc tttctggaga aggtacattg gaaaataatt tgcattagaa cactctactt 52020 tgccttctac agctttacac atcagctgtc ccacagtctc ccttcccagc gggaagatga 52080 attaggcagt aaaggcagtg tccagagtta aagcaagtca gtccattcat tgttttgatc 52140 tgaaccgagg acaccttagc cctctggcga cctcccttgt gggcagcccc agagggtgac 52200 ctgcccgccc actgaccact gtgtgccctg ctccaggtga tggtcctggc gctgatgacg 52260 gtcgagctgt tcggcatgat gggcctcatc ggaatcaagc tcagtgccgt gcccgtggtc 52320 atcctgatcg cttctgttgg cataggagtg gagttcaccg ttcacgttgc tttggtatgg 52380 gagacatttg aagcaaaaac tttgtgaaaa aacaacccat ttcctctggc tctgtttgtc 52440 tccaagtggg aaccttgcat tctccctgtg cgtggcagtg aaaaggcctc agggcacagg 52500 ggccccctag gagagcctgc aagatttctg gattcctttc cctcaaggga ggctaaggag 52560 aggggtatgg aaggtacatg gcagcgggcc ctgtcagccg taggcagtgc agggttggtg 52620 tgttggagtg ggccttgaag ggccgtgctc acctgacttt gactgtcatt atacccccac 52680 gattcctgac gttgtgacgt ttgttcataa ggcggattat gtggtgagtg tgtgggtggg 52740 catacacaga gttttaaaaa caacaggaac agtggggata aaatgagacc acactcacag 52800 gcttggggat ggcatcactg aggatgaggt gagctggcag ccaaggaagt accctcgggc 52860 ttaggagtgg aggctccatt gttcagcccc ggggaactgg ctcttctacc taagcccacc 52920 cagttcctca gacctcccag cctctacatt catgatagca gaaagtaaga gaaccagtgt 52980 tgctttcaac agacattttt ttccctctct ttttctctat cttgccctgt gaatgctttg 53040 ttggaggtaa ttaaacttca gaaggaatct ttagtccaag agataaatct gttgtataca 53100 tttatcaaag aattatccaa aacatcacaa ctgtgtaaat tatgttctgt ctgcagatta 53160 gagcctaaga acttggggtt atcagtaggc attcaataag taaatgcgtt cacctgttaa 53220 atatcgacgt gcgaaatacc ctagctagga agccagcact gggcttgacc aaatcacttc 53280 cgccattgct tttgcaatct ctagcacagg tttcctttgg gctcagcaca tggcacatgc 53340 atgtctccac ataggctgca gccttgtgcc ttctgcagtc tttccagggc tactgtgata 53400 caattgagag attgtaaact tttgtgtttt ggaaggaatg ctttgttgaa gttatcccat 53460 tttttttaca gtgtatcata aaaagccaat aatatggcaa cagtattctc taaattttga 53520 gcctgctcaa attattttct tcctttgagc tgggaggagg gactattttt ttaaaaagaa 53580 gagtgccagc ctagagttta gaaaacccat aattccaata cagttcttca aaagggagat 53640 aaatttgcat gtgagttaag aatccataag ttattttatt ctgatgcaaa tggaaaccac 53700 cttttttgga agctagcagg gcaaatgggt atcccagagc agatttttac catggaaatg 53760 ctaactgcag tctctaaact ctaggacttc tagtccaagt cattttcagt attctgatcc 53820 tctatgtgaa attgcattta gagttggcag ttattgctct ttcaaggttt gtaaaatggt 53880 agaataaggc tgtgaagaag agtcttcttt catgaatgtc tttaggaaat cagtgggttc 53940 ccgttcattt gctgtctcag taacatagaa acagtgtgtg acagggtagt cacaactagg 54000 cccttatggc ctcatggccc aaatatgatg caagccagca tggctgaaaa acccctttgg 54060 tgccttgccc caagagcaga aggcagctat attgacccta atgtctttac caactctgaa 54120 agagtagaac ctgtttgaga gaaaagtatg aaaactctta gcacaccttt gtatatttgt 54180 attttttcat ctgttaagga gaacgaccgt ctcagtcctt ctgcaggtag gtaagggata 54240 gaaacgcatc ctgccaaaga cacccagccc tctcctctcg gcataatcca gagcagcctg 54300 aacttcagag agagaacttg tgccaggttc aacactccct gcaggggtca cacgttcagg 54360 ccaacagtct gatcttccag aatttactct gcaaagttcc cgtttagtta tcaacagcat 54420 ttctggccta ggagagcttt aggactgcag gagagacagg gatgtgtcca cacaatgttc 54480 agaagggctt gattcaaatg tacggtcctg tgtatttctt gcaatacact catagtgctt 54540 agatgtacta caaacatagc ctgaaacagt gacagaaggt ctcacctctg cataatcgtg 54600 aggaagtgtg tgtagcaccc aattgcttgg gacactgagc taagctctta gccatccaat 54660 gcattagcca gaatcctgtg ctgtgggaat tggaggtctc acgtgtgagt ggtgtgagat 54720 catttaagga ggggggaaac ttcggggtga gtatcagtga aaagaagggg acatttctgt 54780 ccatttttat atagttttga ttttactgtg ttcaagattt acgtcaacac caaatatgac 54840 ccagtgtcat gaagaggtca tcttagttta agtctaggtg ctgctagttg agctactctg 54900 attacacatt ctagcaacta aaacagtaag atgtgagcag ttctgagagc ttgtaacatt 54960 taggacagag ctgagcattt accaggtgaa gtccagcaac ctgatcttgt gaacatcctc 55020 attgcacagg cctttctgac ggccatcggc gacaagaacc gcagggctgt gcttgccctg 55080 gagcacatgt ttgcacccgt cctggatggc gccgtgtcca ctctgctggg agtgctgatg 55140 ctggcgggat ctgagttcga cttcattgtc aggtaagcag gcgtgtgcaa ggagacatgt 55200 tttagaaatc attgtgattg ggccgggtgc agtggctcac gcctgtaatc ccagcacttt 55260 aggaggccga ggcgggtgga tcagaaggtc aaggagttca agaccagcct ggccaagatg 55320 gtgaaactca tctccactca aaatacaaaa attagccggg cgtggtggtg ggtgcctgta 55380 atcccagcta cttgggaggc tgaggcagag aattgctcga acccgggagg cggaggttgc 55440 agtgagctga gattgcgcca ctacactcca gcctgggtga cagagcgaga ttctgtctca 55500 aaaaaaaaaa tattgttatt agctcaggtg atcttcgttg cttatttcct tctgtatctg 55560 gtagattgca gcacctcgtc atcgtgactc tgctttcttt tgaacttgtt aacgtagaga 55620 tattcggagg tataaagaca agctctcttc tagagctgtc ttggggagta tcttgaaaac 55680 agaaggtaaa ggatttgggg ctggcagcaa agacaactct gcagcttgaa gccaaaggat 55740 cacccaatag gtggcccatt attgtctcgg gttagaaaca ctgcagaaag aaatgccaca 55800 tttgacctac gctccctctc cttcaaactg tagaaaggaa aacttaaaaa tacctaaaat 55860 tgtcacctga ctttattctt ttaagaagtg aaaatgacgt gctcagattt catattcgag 55920 tccccacaat taggaagcat ttagcattgg actttggtgt caactcttgg gaatctaagc 55980 ctagtttgga tctcaaggca agtcgtttcc agttgattta attaagaata tgactttgtg 56040 aaatataaaa gaacagtgag ttttcctttt gaaaagaatt tgagaactgc agaggaggaa 56100 accacttgct tctttgagca gcctccatgg ctttgtgagg gacctgctct tggatagaac 56160 tctgctactt tatggagctc taaggccaga atcaccaata agtaaaagat agtccaggat 56220 tagaaccatg acagggcaga accagatgtg agaaatgatt ggtttgtttg gcacgcttca 56280 gtactgagag gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tcaagagag agatacgctt 56340 cttatcttca agtaaaaaga agagggtttc aactagaagt tttagccaaa gttttattac 56400 gggaaagaga tgagtccatt ggttggcctg tggcatagcc cactgggcaa tttggcatca 56460 tggaggccgc cttcttagaa tgagtgccaa gcttgcttat tgtagttttt gcatagagtg 56520 aatggtgaag tggaatcgct gtagaccagc gcttctcaca ccgatgtgct gaggaatcat 56580 ctgagggtct aagtgcaggg ccgatttcgg ggggcgggag gtgggatgag ggctgggtct 56640 gcatctccag ctacctccct gcaatgtcca tggagctaga cttctcagca caaactactg 56700 ctaagccagc aagccagttc ctaaattcct gtttgccaat accaagtaga gagttgccca 56760 actgagttaa atgttttggt ctgtgtttta ttttagttct tagtttgatt ttagcttttc 56820 ctttgttctt agtatacact ttttcaggca ctaacgttat cattatgata taaaagctca 56880 atgtcaagta gagtttcttt tgcatattta ctttctcgtt taacaaaat ataacaagca 56940 ccccataagt gccatttgca caacagcaaa taatggggac ccccatatcc ctctgtgtag 57000 cctaaggtct tttaggggag agacaagttc acaggcaaaa ccaggggaaa tgcaaggtgt 57060 gctggggtct catgagttac aggagggtct cgctcagcct tgtgggggat gctgaatgag 57120 gaaacttagc ctgaattaga gcccccagct ggaaacctgg cagctggaat cccagcgctc 57180 tcctctcagc cggggttgtt cccgcccaga aatatcaggg ttcctctttc aagcacttaa 57240 aagggcttcc cattttctag gatgggatgg attaacctga taaaggcctc accaaggtca 57300 aataaatgag cagacactgt atatgctaag ccgtcagaaa tctaattggc ctgtttatgc 57360 ttcagctaga tggatgggat gcaaatgtct taatgtggct gctgatacat gccccagccg 57420 aaagttccag cagtttacat tagaccaaga cattggctgc ttggttttta ctaatgtagt 57480 tcagaagttt ctagtgttta caatagctgt gaggtatttg tatttttatg gggattctct 57540 ctcctttcat ctgatgtcaa aacatatata gacatggcag cactggttgc ctgttccatt 57600 ttatgaacca gaggaccatt aacagataga tatcttgccc cccccttccc agaacatcct 57660 gagcctctcc cctaccccag cccacttcca tcagagttgc cctagaaatc attagttcca 57720 gaaacgcatc cctgcgtgga gtctgtgccc tccagccatg cagagtgtct gccagaggct 57780 gtccctggct gacaggttta ccttggtatt catgaaggat tccagacctt agccctcaat 57840 ggtgggaaag cagaactact tctgcactct cctcctctgc catggtgctg cggcctttat 57900 gtttgaattg gctgacgcaa aacaagagta ttcagagatg ctaaattgtt caacaaaaga 57960 ttggcccgca gagcagcccc gccattgtgg agtgccctca cccagcacaa tgccccagct 58020 cccacagaat gggcagcatt ttctttgcag aaagctggtt cctgtgttct aaaaaggttg 58080 caattggagc tatttggtaa aactggaact cacagaattc taggcagaaa gttgtgatta 58140 atgaaaggcc agggaaagcc ttacctgata tgctagagac ttaattagag attctgccgt 58200 aagatgcaga agcatttcac agtggattag cagcctgcag aagtgggctg cttttcctcc 58260 tgggctaaat tgtttaaatt ctacaccctt cacttcattt gtttgcttct gctgggtttt 58320 cacgagcggg gcccctcggc attgtgtttg tgctttcagt ctgcccagcc attcaggtcg 58380 cattccatat ttttgtgttt gtgtaacaca ttcataaata acattacatg ccatcagagt 58440 tcagcaaatt aacaaactaa tttttttttt cttcccttca tgaactaaca ctttgggttg 58500 tggaatgtag tcctcaaagt cataaggtaa agaaacaaaa agcaaaaact caccttgtgt 58560 tgaatgtgaa ctgcggttgg ataacagcct tttcagtggg gtgggttttg ttcatttctg 58620 gcgttgccat gctgctgtgt cgggcacacg gagggtggcg cgatccaccc tgtcacagcg 58680 cgtgttcccg tttcctcttg atctcccagg tatttctttg ctgtgctggc gatcctcacc 58740 atcctcggcg ttctcaatgg gctggttttg cttcccgtgc ttttgtcttt ctttggacca 58800 tatcctgagg tcagtagtga cacggggatg tcccacgtgt aggccggctg aatgctgtgt 58860 ttcctgtgcc gctcttcact tcgatactta ggtgcctccc cacttgctgg tggttcttca 58920 gtaaacatct cagagtcatg tctgttttcc tcttcggtgt actggctttg agggctagag 58980 ggcgggttcg gtttggttcc tctaaatcaa ctgattggca gcctgggtct tacagatctt 59040 tatacagtaa atgaagactt tccccttgag atgcataatt ggacttcaca agagtaaaaa 59100 gtacacatcc tgcctttcca gtgtggagca gaggacagtt cttctgctcc agctgcggga 59160 cctgaaggtc ctccaggtgg tagagaaggg gaggttaata cggcacagtg cgcagggccc 59220 cagggcaggg aacagaggcc cctgaaaaat accgtgcttt gagctttgag tgtggccagc 59280 aggtaaatgg acaagaacac ttttaacatg gaatcccctt aaataggtgt ctccagccaa 59340 cggcttgaac cgcctgccca caccctcccc tgagccaccc cccagcgtgg tccgcttcgc 59400 catgccgccc ggccacacgc acagcgggtc tgattcctcc gactcggagt atagttccca 59460 gacgacagtg tcaggcctca gcgaggagct tcggcactac gaggcccagc agggcgcggg 59520 aggccctgcc caccaagtga tcgtggaagc cacagaaaac cccgtcttcg cccactccac 59580 tgtaagtgac tctgcagaac cagggggagg ggtcttccca ccgtggtagt gggcctggag 59640 gtccagcggg ggctcctgtc tgctgagcag cacatcacac aggcagatgg gatgcagaga 59700 taaggtacag actaggtcaa atcataggaa ataaccagta tttaactctt tctcaactat 59760 acaaatgcca tcttcctgtg gtttgatctc ataaaggata aaaagggcag gggccagtaa 59820 tgtcactgca caaagcagta gcatctatct tgttcagggt gaggacagtt tgggcttcaa 59880 aggccagaga taaagcattc ctgccttttt tttttttttc ctcttaaggt gcatgtcatt 59940 tgagagtgat attttctaaa actagtagta tttttattgc caacagaggt caggtttttt 60000 ccttctctca tttctgttag gtttcaatgc ccttgataca acattcatta ttattgtcta 60060 aatactttac catagctttt ggggctccaa gctcatgttc caggtggcag gaaagagcag 60120 agaggccaag aaccacccct gagttcttag ccttcagtga ttcaggaggt caccaggagc 60180 ctgggagccc ctcctcggag gctccaagga cctgggtcct ttcctccacc ctgtgctccc 60240 tgggatgggc tcagccctga aaactcaagg aaggttctgg gctgatgttg ctccactgag 60300 ggccccctgc tgtccctcca ggaaatgggt attccagtcc caggccagag cagcccttcc 60360 gtgaaagaga gaaaggccaa ccaaataacc tgaattgtcc tcctcctacc ccccgcgacg 60420 acgcccgctg agctgcagtg tgaatctggt tttgttcagc aggagcctaa aaataggtac 60480 aagctgaacg actttgaagt tggtcacggt ccttttgatt gatgtggcca ctgtgttgct 60540 ctgtgctttg tatagagacg cagagaccag attcttaaca atcagatgga acaggctgcc 60600 cgccacagcc ctccgcagtg acgaaaatgc cctctctgct ttccaggatg ggagccaccg 60660 gccacacgtg gctgtggagc acttgaaatg tggccggggc taccgaggag ctggattttg 60720 gattttagtt cattaaaact taagcaacca catgtctgga gcggctactg tgtttgacag 60780 agtaggcaga gacagtcctg ccagcgtcct gcactcaggc cagccagggc cgcacactta 60840 gcaacttcgg gagaggggca gctcagagcc tgcagaacct aacagggtcg ggggcaggtt 60900 gtggggggca gcagcttgga tgctctgacc acagcccaca tttatgggca gcagcagtac 60960 gtgtccagcc agccgtgtca gagaaagcct ggaaacagga ttttcaaaca acacgctcct 61020 ccgccaggtc ctggaggtta ttagaaggac aggcttttct tttgtgggtg gaaggccccc 61080 attggctccc cagggttgac tgagtctttg gtgaaaccca aggagggaag tgtgggagct 61140 gcggggacca tgcccagcct gggataccac ccttctaacc caccctcacc ctctgcaggt 61200 ggtccatccc gaatccaggc atcacccacc ctcgaacccg agacagcagc cccacctgga 61260 ctcagggtcc ctgcctcccg gacggcaagg ccagcagccc cgcagggacc cccccagaga 61320 aggcttgtgg ccacccccct acagaccgcg cagagacgct tttgaaattt ctactgaagg 61380 gcattctggc cctagcaata gggcccgctg gggccctcgc ggggcccgtt ctcacaaccc 61440 tcggaaccca gcgtccactg ccatgggcag ctccgtgccc ggctactgcc agcccatcac 61500 cactgtgacg gcttctgcct ccgtgactgt cgccgtgcac ccgccgcctg tccctgggcc 61560 tgggcggaac ccccgagggg gactctgccc aggctaccct gagactgacc acggcctgtt 61620 tgaggacccc cacgtgcctt tccacgtccg gtgtgagagg agggattcga aggtggaagt 61680 cattgagctg caggacgtgg aatgcgagga gaggccccgg ggaagcagct ccaactgagg 61740 tgagtgccac tgacaagggc agccaaggga cctagagcca ggcaaagagg aggacaaggt 61800 tctcctgggg ttctcggcat ccccgagggg ctgtggcgct cgggcacatc ccacgctgga 61860 ccccagtgac cttttatccc cagagcaagg ctgatgtgtc caagctttgt catccttggg 61920 gaaccagtcc agctccacac tgctctcttc ccccactgct aacctgcgga gggtcggtgc 61980 agcgccacaa ggacacaaac agcaccacct tttaccaata tttgccagtc tttatggagg 62040 tgcatgccac agcgaattgg tcacatggga acgcatccgt gtaaccagcc cccagatgaa 62100 gggagaggtc acaagcagcc cccagggaca cctcaggccc acaccccact ctcgtgattt 62160 ctaataccaa ggttactgct gcctgctttt gtactttata aatacggact tgcacacctc 62220 ttactctgtt caacttcctt ttttgcttcc ttttaaaggg tgattaaaat ctgaagcaaa 62280 gaggccaaag attggaaacc ccccaccccc acctctttcc agaactgctt gaagagaact 62340 ggttggagtt atggaaaaga tgccctgtgc caggacagca gttcattgtt actgtaaccg 62400 attgtattat tttgttaaat atttctataa atatttaaga gatgtacaca tgtgtaatat 62460 aggaaggaag gatgtaaagt ggtatgatct ggggcttctc cactcctgcc ccagagtgtg 62520 gaggccacag tggggcctct ccgtatttgt gcattgggct ccgtgccaca accaagcttc 62580 attagtctta aatttcagca tatgttgctg ctgcttaaat attgtataat ttacttgtat 62640 aattctatgc aaatattgct tatgtaatag gattattttg taaaggtttc tgtttaaaat 62700 attttaaatt tgcatatcac aaccctgtgg tagtatgaaa tgttactgtt aactttcaaa 62760 cacgctatgc gtgataattt ttttgtttaa tgagcagata tgaagaaagc acgttaatcc 62820 tggtggcttc tctaggtgtc gttgtgtgcg gtcctcttgt ttggctgtgc gtgtgaacac 62880 gtgtgtgagt tcaccatgta ctgtactgtg attttttttt tgtcttgttt tgtttctcta 62940 cactgtctgt aacctgtagt aggctctgac ctagtcaggc tggaagcgtc aggatatctt 63000 ttcttcgtgc tggtgagggc tggccctaaa catccaccta atcctttcaa atcagcccgg 63060 caaaagctag actctcctcg tgtctacggc atctcttatg atcattggct gccatccagg 63120 accccaattt gtgcttcagg gggataatct ccttctctcg gatcattgtg atggatgctg 63180 gaacctcagg gtatggagct cacatcagtt catcatggtg ggtgttagag aattcggtga 63240 catgcctagt gctgagcctt ggctgggcca tgagagtctg tatactctaa aaagcatgca 63300 gcatggtgcc cctcttctga ccaacacaca cacgacccct cccccaacac ccccaaattc 63360 aagagtggat gtggccctgt cacaggtaga aaaacctatt tagttaattc tttcttggcc 63420 cacagtctcc cagaaatgat gttttgagtc cctatagttt aaactccctc tcttaaatgg 63480 agcagctggt tgaggctttc tagatctgtt tgcatcttct ttaaaactaa gtggtgagca 63540 tgcattgtgg tgtagaggca ggcattatgt aggataagag ctccgggggg attcttcatg 63600 caccagtgtt tagggtacgt gcttcctaag taaatccaaa cattgtctcc atcctccccg 63660 tcattagtgc tctttcaatg tgatgtggga aagcaggagg atggacacac cccactgaaa 63720 gatgtaggca ggggcaggtc tctcaaccag gcatattttt aaaagttgct tctgtactgg 63780 ttctcttctt ttgctctgag gtgtgggctc cctcatctcg taaccagaga ccagcacatg 63840 tcagggaagc acccagtgtc ggctccccat ccaaatccac accagcacct tgttacagac 63900 aagaagtcag aggaaagggc ggggtccctg cagggctgaa gcctaagcta ctgtgaggcg 63960 ctcacgagtg gcagctcctg ttactccctt ttaaattacc tgggaaatct taacagaaag 64020 gtaatgggcc cccagaaata cccacagcat agtgacctca gaccctgata ctcaccacaa 64080 aacttttaag atgctgattg ggagccgctt gtggctgctg ggtgtgtgtg tgtgtgtgtg 64140 cgtgcgtgcg tgtgtgtgtg tctctgctgg ggaccctggc cacccccctg ctgctgtctt 64200 ggtgcctgtc acccacatgg tctgccatcc taacacccag ctctgctcag aaaacgtcct 64260 gcgtggagga gggatgatgc agaattctga agtcgacttc cctctggctc ctggcgtgcc 64320 ctcgctccct tcctgagccc agctcgtgtt gcgccggagg ctgcgcggcc cctgatttct 64380 gcatggtgta gaactttctc caatagtcac attggcaaag ggagaactgg ggtgggcggg 64440 gggtggggct ggcagggaat tagaatttct ctctctcttt taatagtttt attttgtctg 64500 tcctgtttgt tcatttggat gttttaattt ttaaaaaaaa aaaaactttg ctgatattta 64560 taattttgta tcataagaat gttttcctct acagtatttg tcatgccagt ttataacaaa 64620 aaaaaatgca gggattttat ttctattgga aacattacag ctatgtttta cttttggaca 64680 gaatttttat ttgtatagag tgcttactaa tgttaaatag ttcagagtat ataacattta 64740 cattaaggac tcatggtagg ttttagggta aggagtttaa aggaaataaa tattcaaact 64800 gggtctcatt gccaattttg gtggaaatga gtttgtgtca tttcaattac aaagataaaa 64860 gtatgccata taatttattt atatgaagat ttatttttgt agtgtacata gtagtcatca 64920 agtcttttga cagaagtata tttttaaaga atttatatgt gatgaatcca taatgtctgg 64980 aactttgctg agacatgagt gggcacagtt ttcattgtaa attacagcaa ggaaagaaaa 65040 tgtttaacag tgttaagaga gtcagagcag agtggatatt catgcgatta tgaagtgttt 65100 attagttacc attggcgacc tagcatgctt ctcatttcaa accttggaag gtgaaaatgt 65160 acaaactctc taaataatta atgttcaaac actgatagaa attctaacat gaataaaaaa 65220 taatataact tgttggttat atctttgttt gtagaatgct ttttttcttt aaaatacttg 65280 ggagagacag ttagtgttgg agccatcaga aactgttgtt tcatcttgct gaccttgtga 65340 cactcttctt ttttgctcta tctgatggag agagttttag gttttcctcc tttttgtttt 65400 gtataaatag tgggtataag catagctctg ttacatggat gtattacaaa gtggggggctg 65460 agcttttagt gtgatcatca cccaaatagt gtacattgta cccattaatt aatttcttat 65520 cacctgaccc tatttttgtt ttctcatacc aagaaacttc ctaagttaac catcaaaatt 65580 agtccttctg tcatctctct tagcatactt atttccctta tgtgatgcct aataatgagg 65640 gaacataaat aaagccaaat tcaaagatga ttatcatcag tgaaggtgtc atacttctaa 65700 acagtgtcaa agataatatg gaattgattg aacctgatac agaacagttt ttgagtgttt 65760 cctggtaagc 65770 <210> 7 <211> 729 <212> PRT <213> Homo sapiens <400> 7 Met Asn Lys Gly Trp Leu Glu Leu Glu Ser Asp Pro Gly Leu Phe Thr 1 5 10 15 Leu Leu Val Glu Asp Phe Gly Val Lys Gly Val Gln Val Glu Glu Ile 20 25 30 Tyr Asp Leu Gln Ser Lys Cys Gln Gly Pro Val Tyr Gly Phe Ile Phe 35 40 45 Leu Phe Lys Trp Ile Glu Glu Arg Arg Ser Arg Arg Lys Val Ser Thr 50 55 60 Leu Val Asp Asp Thr Ser Val Ile Asp Asp Asp Ile Val Asn Asn Met 65 70 75 80 Phe Phe Ala His Gln Leu Ile Pro Asn Ser Cys Ala Thr His Ala Leu 85 90 95 Leu Ser Val Leu Leu Asn Cys Ser Ser Val Asp Leu Gly Pro Thr Leu 100 105 110 Ser Arg Met Lys Asp Phe Thr Lys Gly Phe Ser Pro Glu Ser Lys Gly 115 120 125 Tyr Ala Ile Gly Asn Ala Pro Glu Leu Ala Lys Ala His Asn Ser His 130 135 140 Ala Arg Pro Glu Pro Arg His Leu Pro Glu Lys Gln Asn Gly Leu Ser 145 150 155 160 Ala Val Arg Thr Met Glu Ala Phe His Phe Val Ser Tyr Val Pro Ile 165 170 175 Thr Gly Arg Leu Phe Glu Leu Asp Gly Leu Lys Val Tyr Pro Ile Asp 180 185 190 His Gly Pro Trp Gly Glu Asp Glu Glu Trp Thr Asp Lys Ala Arg Arg 195 200 205 Val Ile Met Glu Arg Ile Gly Leu Ala Thr Ala Gly Glu Pro Tyr His 210 215 220 Asp Ile Arg Phe Asn Leu Met Ala Val Val Pro Asp Arg Arg Ile Lys 225 230 235 240 Tyr Glu Ala Arg Leu His Val Leu Lys Val Asn Arg Gln Thr Val Leu 245 250 255 Glu Ala Leu Gln Gln Leu Ile Arg Val Thr Gln Pro Glu Leu Ile Gln 260 265 270 Thr His Lys Ser Gln Glu Ser Gln Leu Pro Glu Glu Ser Lys Ser Ala 275 280 285 Ser Asn Lys Ser Pro Leu Val Leu Glu Ala Asn Arg Ala Pro Ala Ala 290 295 300 Ser Glu Gly Asn His Thr Asp Gly Ala Glu Glu Ala Ala Gly Ser Cys 305 310 315 320 Ala Gln Ala Pro Ser His Ser Pro Pro Asn Lys Pro Lys Leu Val Val 325 330 335 Lys Pro Pro Gly Ser Ser Leu Asn Gly Val His Pro Asn Pro Thr Pro 340 345 350 Ile Val Gln Arg Leu Pro Ala Phe Leu Asp Asn His Asn Tyr Ala Lys 355 360 365 Ser Pro Met Gln Glu Glu Glu Asp Leu Ala Ala Gly Val Gly Arg Ser 370 375 380 Arg Val Pro Val Arg Pro Pro Gln Gln Tyr Ser Asp Asp Glu Asp Asp 385 390 395 400 Tyr Glu Asp Asp Glu Glu Asp Asp Val Gln Asn Thr Asn Ser Ala Leu 405 410 415 Arg Tyr Lys Gly Lys Gly Thr Gly Lys Pro Gly Ala Leu Ser Gly Ser 420 425 430 Ala Asp Gly Gln Leu Ser Val Leu Gln Pro Asn Thr Ile Asn Val Leu 435 440 445 Ala Glu Lys Leu Lys Glu Ser Gln Lys Asp Leu Ser Ile Pro Leu Ser 450 455 460 Ile Lys Thr Ser Ser Gly Ala Gly Ser Pro Ala Val Ala Val Pro Thr 465 470 475 480 His Ser Gln Pro Ser Pro Thr Pro Ser Asn Glu Ser Thr Asp Thr Ala 485 490 495 Ser Glu Ile Gly Ser Ala Phe Asn Ser Pro Leu Arg Ser Pro Ile Arg 500 505 510 Ser Ala Asn Pro Thr Arg Pro Ser Ser Pro Val Thr Ser His Ile Ser 515 520 525 Lys Val Leu Phe Gly Glu Asp Asp Ser Leu Leu Arg Val Asp Cys Ile 530 535 540 Arg Tyr Asn Arg Ala Val Arg Asp Leu Gly Pro Val Ile Ser Thr Gly 545 550 555 560 Leu Leu His Leu Ala Glu Asp Gly Val Leu Ser Pro Leu Ala Leu Thr 565 570 575 Glu Gly Gly Lys Gly Ser Ser Pro Ser Ile Arg Pro Ile Gln Gly Ser 580 585 590 Gln Gly Ser Ser Ser Pro Val Glu Lys Glu Val Val Glu Ala Thr Asp 595 600 605 Ser Arg Glu Lys Thr Gly Met Val Arg Pro Gly Glu Pro Leu Ser Gly 610 615 620 Glu Lys Tyr Ser Pro Lys Glu Leu Leu Ala Leu Leu Lys Cys Val Glu 625 630 635 640 Ala Glu Ile Ala Asn Tyr Glu Ala Cys Leu Lys Glu Glu Val Glu Lys 645 650 655 Arg Lys Lys Phe Lys Ile Asp Asp Gln Arg Arg Thr His Asn Tyr Asp 660 665 670 Glu Phe Ile Cys Thr Phe Ile Ser Met Leu Ala Gln Glu Gly Met Leu 675 680 685 Ala Asn Leu Val Glu Gln Asn Ile Ser Val Arg Arg Arg Gln Gly Val 690 695 700 Ser Ile Gly Arg Leu His Lys Gln Arg Lys Pro Asp Arg Arg Lys Arg 705 710 715 720 Ser Arg Pro Tyr Lys Ala Lys Arg Gln 725 <210> 8 <211> 303 <212> PRT <213> Homo sapiens <400> 8 Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 1 5 10 15 Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 20 25 30 Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly Gly 35 40 45 Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 50 55 60 Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 65 70 75 80 Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 85 90 95 Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 100 105 110 Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 115 120 125 Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 130 135 140 Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 145 150 155 160 Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 165 170 175 Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 180 185 190 Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 195 200 205 Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 210 215 220 Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 225 230 235 240 Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 245 250 255 Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 260 265 270 Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 275 280 285 Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 290 295 300 <210> 9 <211> 1240 <212> PRT <213> Homo sapiens <400> 9 Met Pro Arg Gly Ser Trp Lys Pro Gln Val Cys Thr Gly Thr Asp Met 1 5 10 15 Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg 20 25 30 His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr 35 40 45 Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu 50 55 60 Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro 65 70 75 80 Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 85 90 95 Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr 100 105 110 Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg 115 120 125 Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro 130 135 140 Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys 145 150 155 160 Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala 165 170 175 Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu 180 185 190 Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly 195 200 205 Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln 210 215 220 Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 225 230 235 240 Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 245 250 255 Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly 260 265 270 Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr 275 280 285 Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn 290 295 300 Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 305 310 315 320 Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 325 330 335 Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys 340 345 350 Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 355 360 365 Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val 370 375 380 Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 385 390 395 400 Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile 405 410 415 Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly 420 425 430 Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 435 440 445 Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr 450 455 460 Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 465 470 475 480 Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys 485 490 495 His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 500 505 510 Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 515 520 525 Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His 530 535 540 Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr 545 550 555 560 Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys 565 570 575 Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 580 585 590 Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys 595 600 605 Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp 610 615 620 Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile 625 630 635 640 Ser Ala Val Val Gly Ile Leu Leu Val Val Val Val Leu Gly Val Val Phe 645 650 655 Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 660 665 670 Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser 675 680 685 Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu 690 695 700 Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 705 710 715 720 Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala 725 730 735 Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile 740 745 750 Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser 755 760 765 Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln 770 775 780 Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly 785 790 795 800 Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys 805 810 815 Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala 820 825 830 Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp 835 840 845 Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala 850 855 860 Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 865 870 875 880 Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 885 890 895 Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro 900 905 910 Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln 915 920 925 Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 930 935 940 Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu 945 950 955 960 Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn 965 970 975 Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser 980 985 990 Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr 995 1000 1005 Leu Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala 1010 1015 1020 Gly Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly 1025 1030 1035 1040 Gly Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro 1045 1050 1055 Arg Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp 1060 1065 1070 Gly Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr 1075 1080 1085 His Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro 1090 1095 1100 Leu Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro 1105 1110 1115 1120 Gln Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser 1125 1130 1135 Pro Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu 1140 1145 1150 Glu Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp 1155 1160 1165 Val Phe Ala Phe Gly Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro 1170 1175 1180 Gln Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro 1185 1190 1195 1200 Ala Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly 1205 1210 1215 Ala Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu 1220 1225 1230 Tyr Leu Gly Leu Asp Val Pro Val 1235 1240 <210> 10 <211> 792 <212> PRT <213> Homo sapiens <400> 10 Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 1 5 10 15 Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 20 25 30 Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 35 40 45 Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 50 55 60 Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 65 70 75 80 Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 85 90 95 Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 100 105 110 Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 115 120 125 Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 130 135 140 Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 145 150 155 160 Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 165 170 175 Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 180 185 190 Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 195 200 205 Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 210 215 220 Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 225 230 235 240 Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 245 250 255 Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 260 265 270 Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 275 280 285 Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 290 295 300 Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 305 310 315 320 Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 325 330 335 Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 340 345 350 Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 355 360 365 Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 370 375 380 Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 385 390 395 400 Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 405 410 415 Phe Pro Leu Lys Arg Gln Gln Val Ser Leu Glu Ser Asn Ala Ser Met 420 425 430 Ser Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu 435 440 445 Gly Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro 450 455 460 Lys Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly 465 470 475 480 Glu Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp 485 490 495 Lys Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys 500 505 510 Asp Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu 515 520 525 Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly 530 535 540 Ala Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala 545 550 555 560 Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu 565 570 575 Asp Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe 580 585 590 Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr 595 600 605 Leu Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val 610 615 620 Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala 625 630 635 640 Arg Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Leu Val 645 650 655 Leu Trp Gly Pro Ala Leu Gly Asp Leu His Ala Gly Gly Leu Pro Val 660 665 670 Pro Arg His Pro Cys Gly Gly Ala Leu Gln Ala Ala Glu Gly Gly Pro 675 680 685 Pro His Gly Gln Ala Arg Gln Leu His Thr Arg Pro Val His Asp His 690 695 700 Ala Gly Val Leu Ala Cys Arg Ala Leu Pro Glu Ala His Leu Gln Ala 705 710 715 720 Ala Gly Gly Gly Pro Gly Pro Cys Pro Tyr Arg Asp Val His Arg Arg 725 730 735 Val Pro Gly Pro Val Gly Ala Phe Arg Ala Val Leu Pro Gly Trp Pro 740 745 750 Gly His Pro Gln Leu Gln Leu Leu Arg Gly Arg Leu Arg Val Cys Pro 755 760 765 Arg Pro Ala Ala Pro Gly Pro Thr Gln Gln Trp Gly Leu Ala Asp Val 770 775 780 Lys Gly His Trp Ser Pro Thr Met 785 790 <210> 11 <211> 234 <212> PRT <213> Homo sapiens <400> 11 Met Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg 1 5 10 15 Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro 20 25 30 Gln His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp 35 40 45 Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 50 55 60 Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn 65 70 75 80 Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile 85 90 95 Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu 100 105 110 Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu 115 120 125 Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser 130 135 140 Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys 145 150 155 160 Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 165 170 175 Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 180 185 190 Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser 195 200 205 His Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu 210 215 220 Met Phe Lys Thr Glu Gly Pro Asp Ser Asp 225 230 <210> 12 <211> 1395 <212> PRT <213> Homo sapiens <400> 12 Met Ala Ser Ala Gly Asn Ala Ala Glu Pro Gln Asp Arg Gly Gly Gly 1 5 10 15 Gly Ser Gly Cys Ile Gly Ala Pro Gly Arg Pro Ala Gly Gly Gly Arg 20 25 30 Arg Arg Arg Thr Gly Gly Leu Arg Arg Arg Ala Ala Ala Pro Asp Arg Asp 35 40 45 Tyr Leu His Arg Pro Ser Tyr Cys Asp Ala Ala Phe Ala Leu Glu Gln 50 55 60 Ile Ser Lys Gly Lys Ala Thr Gly Arg Lys Ala Pro Leu Trp Leu Arg 65 70 75 80 Ala Lys Phe Gln Arg Leu Leu Phe Lys Leu Gly Cys Tyr Ile Gln Lys 85 90 95 Asn Cys Gly Lys Phe Leu Val Val Gly Leu Leu Ile Phe Gly Ala Phe 100 105 110 Ala Val Gly Leu Lys Ala Ala Asn Leu Glu Thr Asn Val Glu Glu Leu 115 120 125 Trp Val Glu Val Gly Gly Arg Val Ser Arg Glu Leu Asn Tyr Thr Arg 130 135 140 Gln Lys Ile Gly Glu Glu Ala Met Phe Asn Pro Gln Leu Met Ile Gln 145 150 155 160 Thr Pro Lys Glu Glu Gly Ala Asn Val Leu Thr Thr Glu Ala Leu Leu 165 170 175 Gln His Leu Asp Ser Ala Leu Gln Ala Ser Arg Val His Val Tyr Met 180 185 190 Tyr Asn Arg Gln Trp Lys Leu Glu His Leu Cys Tyr Lys Ser Gly Glu 195 200 205 Leu Ile Thr Glu Thr Gly Tyr Met Asp Gln Ile Ile Glu Tyr Leu Tyr 210 215 220 Pro Cys Leu Ile Ile Thr Pro Leu Asp Cys Phe Trp Glu Gly Ala Lys 225 230 235 240 Leu Gln Ser Gly Thr Ala Tyr Leu Leu Gly Lys Pro Leu Arg Trp 245 250 255 Thr Asn Phe Asp Pro Leu Glu Phe Leu Glu Glu Leu Lys Lys Ile Asn 260 265 270 Tyr Gln Val Asp Ser Trp Glu Glu Met Leu Asn Lys Ala Glu Val Gly 275 280 285 His Gly Tyr Met Asp Arg Pro Cys Leu Asn Pro Ala Asp Pro Asp Cys 290 295 300 Pro Ala Thr Ala Pro Asn Lys Asn Ser Thr Lys Pro Leu Asp Met Ala 305 310 315 320 Leu Val Leu Asn Gly Gly Cys His Gly Leu Ser Arg Lys Tyr Met His 325 330 335 Trp Gln Glu Glu Leu Ile Val Gly Gly Thr Val Lys Asn Ser Thr Gly 340 345 350 Lys Leu Val Ser Ala His Ala Leu Gln Thr Met Phe Gln Leu Met Thr 355 360 365 Pro Lys Gln Met Tyr Glu His Phe Lys Gly Tyr Glu Tyr Val Ser His 370 375 380 Ile Asn Trp Asn Glu Asp Lys Ala Ala Ala Ile Leu Glu Ala Trp Gln 385 390 395 400 Arg Thr Tyr Val Glu Val Val His Gln Ser Val Ala Gln Asn Ser Thr 405 410 415 Gln Lys Val Leu Ser Phe Thr Thr Thr Thr Leu Asp Asp Ile Leu Lys 420 425 430 Ser Phe Ser Asp Val Ser Val Ile Arg Val Ala Ser Gly Tyr Leu Leu 435 440 445 Met Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Phe 450 455 460 Leu Leu Ala His Ala Phe Ser Glu Thr Gly Gln Asn Lys Arg Ile Pro 465 470 475 480 Phe Glu Asp Arg Thr Gly Glu Cys Leu Lys Arg Thr Gly Ala Ser Val 485 490 495 Ala Leu Thr Ser Ile Ser Asn Val Thr Ala Phe Phe Met Ala Ala Leu 500 505 510 Ile Pro Ile Pro Ala Leu Arg Ala Phe Ser Leu Gln Ala Ala Val Val 515 520 525 Val Val Phe Asn Phe Ala Met Val Leu Leu Ile Phe Pro Ala Ile Leu 530 535 540 Ser Met Asp Leu Tyr Arg Arg Glu Asp Arg Arg Leu Asp Ile Phe Cys 545 550 555 560 Cys Phe Thr Ser Pro Cys Val Ser Arg Val Ile Gln Val Glu Pro Gln 565 570 575 Ala Tyr Thr Asp Thr His Asp Asn Thr Arg Tyr Ser Pro Pro Pro Pro 580 585 590 Tyr Ser Ser His Ser Phe Ala His Glu Thr Gln Ile Thr Met Gln Ser 595 600 605 Thr Val Gln Leu Arg Thr Glu Tyr Asp Pro His Thr His Val Tyr Tyr 610 615 620 Thr Thr Ala Glu Pro Arg Ser Glu Ile Ser Val Gln Pro Val Thr Val 625 630 635 640 Thr Gln Asp Thr Leu Ser Cys Gln Ser Pro Glu Ser Thr Ser Ser Thr 645 650 655 Arg Asp Leu Leu Ser Gln Phe Ser Asp Ser Ser Leu His Cys Leu Glu 660 665 670 Pro Pro Cys Thr Lys Trp Thr Leu Ser Ser Phe Ala Glu Lys His Tyr 675 680 685 Ala Pro Phe Leu Leu Lys Pro Lys Ala Lys Val Val Val Ile Phe Leu 690 695 700 Phe Leu Gly Leu Leu Gly Val Ser Leu Tyr Gly Thr Thr Arg Val Arg 705 710 715 720 Asp Gly Leu Asp Leu Thr Asp Ile Val Pro Arg Glu Thr Arg Glu Tyr 725 730 735 Asp Phe Ile Ala Ala Gln Phe Lys Tyr Phe Ser Phe Tyr Asn Met Tyr 740 745 750 Ile Val Thr Gln Lys Ala Asp Tyr Pro Asn Ile Gln His Leu Leu Tyr 755 760 765 Asp Leu His Arg Ser Phe Ser Asn Val Lys Tyr Val Met Leu Glu Glu 770 775 780 Asn Lys Gln Leu Pro Lys Met Trp Leu His Tyr Phe Arg Asp Trp Leu 785 790 795 800 Gln Gly Leu Gln Asp Ala Phe Asp Ser Asp Trp Glu Thr Gly Lys Ile 805 810 815 Met Pro Asn Asn Tyr Lys Asn Gly Ser Asp Asp Gly Val Leu Ala Tyr 820 825 830 Lys Leu Leu Val Gln Thr Gly Ser Arg Asp Lys Pro Ile Asp Ile Ser 835 840 845 Gln Leu Thr Lys Gln Arg Leu Val Asp Ala Asp Gly Ile Ile Asn Pro 850 855 860 Ser Ala Phe Tyr Ile Tyr Leu Thr Ala Trp Val Ser Asn Asp Pro Val 865 870 875 880 Ala Tyr Ala Ala Ser Gln Ala Asn Ile Arg Pro His Arg Pro Glu Trp 885 890 895 Val His Asp Lys Ala Asp Tyr Met Pro Glu Thr Arg Leu Arg Ile Pro 900 905 910 Ala Ala Glu Pro Ile Glu Tyr Ala Gln Phe Pro Phe Tyr Leu Asn Gly 915 920 925 Leu Arg Asp Thr Ser Asp Phe Val Glu Ala Ile Glu Lys Val Arg Thr 930 935 940 Ile Cys Ser Asn Tyr Thr Ser Leu Gly Leu Ser Ser Tyr Pro Asn Gly 945 950 955 960 Tyr Pro Phe Leu Phe Trp Glu Gln Tyr Ile Gly Leu Arg His Trp Leu 965 970 975 Leu Leu Phe Ile Ser Val Val Leu Ala Cys Thr Phe Leu Val Cys Ala 980 985 990 Val Phe Leu Leu Asn Pro Trp Thr Ala Gly Ile Ile Val Met Val Leu 995 1000 1005 Ala Leu Met Thr Val Glu Leu Phe Gly Met Met Gly Leu Ile Gly Ile 1010 1015 1020 Lys Leu Ser Ala Val Pro Val Val Ile Leu Ile Ala Ser Val Gly Ile 1025 1030 1035 1040 Gly Val Glu Phe Thr Val His Val Ala Leu Ala Phe Leu Thr Ala Ile 1045 1050 1055 Gly Asp Lys Asn Arg Arg Ala Val Leu Ala Leu Glu His Met Phe Ala 1060 1065 1070 Pro Val Leu Asp Gly Ala Val Ser Thr Leu Leu Gly Val Leu Met Leu 1075 1080 1085 Ala Gly Ser Glu Phe Asp Phe Ile Val Arg Tyr Phe Phe Ala Val Leu 1090 1095 1100 Ala Ile Leu Thr Ile Leu Gly Val Leu Asn Gly Leu Val Leu Leu Pro 1105 1110 1115 1120 Val Leu Leu Ser Phe Phe Gly Pro Tyr Pro Glu Val Ser Pro Ala Asn 1125 1130 1135 Gly Leu Asn Arg Leu Pro Thr Pro Ser Pro Glu Pro Pro Pro Ser Val 1140 1145 1150 Val Arg Phe Ala Met Pro Pro Gly His Thr His Ser Gly Ser Asp Ser 1155 1160 1165 Ser Asp Ser Glu Tyr Ser Ser Gln Thr Thr Val Ser Gly Leu Ser Glu 1170 1175 1180 Glu Leu Arg His Tyr Glu Ala Gln Gln Gly Ala Gly Gly Pro Ala His 1185 1190 1195 1200 Gln Val Ile Val Glu Ala Thr Glu Asn Pro Val Phe Ala His Ser Thr 1205 1210 1215 Val Val His Pro Glu Ser Arg His His Pro Ser Asn Pro Arg Gln 1220 1225 1230 Gln Pro His Leu Asp Ser Gly Ser Leu Pro Pro Gly Arg Gln Gly Gln 1235 1240 1245 Gln Pro Arg Arg Asp Pro Pro Arg Glu Gly Leu Trp Pro Pro Pro Tyr 1250 1255 1260 Arg Pro Arg Arg Asp Ala Phe Glu Ile Ser Thr Glu Gly His Ser Gly 1265 1270 1275 1280 Pro Ser Asn Arg Ala Arg Trp Gly Pro Arg Gly Ala Arg Ser His Asn 1285 1290 1295 Pro Arg Asn Pro Ala Ser Thr Ala Met Gly Ser Ser Val Pro Gly Tyr 1300 1305 1310 Cys Gln Pro Ile Thr Thr Val Thr Ala Ser Ala Ser Val Thr Val Ala 1315 1320 1325 Val His Pro Pro Pro Val Pro Gly Pro Gly Arg Asn Pro Arg Gly Gly 1330 1335 1340 Leu Cys Pro Gly Tyr Pro Glu Thr Asp His Gly Leu Phe Glu Asp Pro 1345 1350 1355 1360 His Val Pro Phe His Val Arg Cys Glu Arg Arg Asp Ser Lys Val Glu 1365 1370 1375 Val Ile Glu Leu Gln Asp Val Glu Cys Glu Glu Arg Pro Arg Gly Ser 1380 1385 1390 Ser Ser Asn 1395

Claims (13)

a polynucleotide comprising a BAP1 mutation, consisting of a polynucleotide sequence in which base T at position 548 is substituted with C in the polynucleotide consisting of the sequence of SEQ ID NO: 1;
a polynucleotide comprising a CDK4 mutation consisting of a polynucleotide sequence in which C is inserted between bases 753 and 754 in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 2;
a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1966th base T is substituted with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;
a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1147th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;
a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which the 1900th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;
a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which base G at 1672 is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;
a polynucleotide comprising a TP53 mutation consisting of a polynucleotide sequence in which the 31st base G is replaced with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 5;
a polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 3785 is replaced with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6; and
A diagnostic marker set for ovarian cancer, comprising a polynucleotide comprising a PTCH1 mutation comprising a polynucleotide sequence in which base C at position 37943 is replaced with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6. A composition for diagnosing ovarian cancer, comprising a primer or probe that specifically binds to the polynucleotide according to claim 1. delete BAP1 mutant protein in which L, which is the 183th amino acid residue in the amino acid sequence of SEQ ID NO: 7, is substituted with P;
CDK4 mutant protein in which the 252th amino acid residue R in the amino acid sequence of SEQ ID NO: 8 is frameshifted;
ERBB2 mutant protein in which S, which is the 656th amino acid residue in the amino acid sequence of SEQ ID NO: 9, is substituted with P;
ERBB2 mutant protein in which G, which is the 383th amino acid residue in the amino acid sequence of SEQ ID NO: 9, is substituted with R;
FGFR3 mutant protein in which A, which is the 634th amino acid residue in the amino acid sequence of SEQ ID NO: 10, is substituted with T;
FGFR3 mutant protein in which A, which is the 558th amino acid residue in the amino acid sequence of SEQ ID NO: 10, is substituted with T;
TP53 mutant protein in which E, which is the 11th amino acid residue in the amino acid sequence of SEQ ID NO: 11, is substituted with Q;
PTCH1 mutant protein in which P, which is the 1262th amino acid residue in the amino acid sequence of SEQ ID NO: 12, is substituted with L; and
A set of ovarian cancer diagnostic markers comprising a PTCH1 mutant protein in which P, which is the 1315th amino acid residue in the amino acid sequence of SEQ ID NO: 12, is substituted with S. A composition for diagnosing ovarian cancer, comprising an agent capable of detecting the expression of the mutant protein according to claim 4 . 6. The method of claim 5,
The formulation will include an antibody or aptamer that specifically binds to the mutant protein, ovarian cancer diagnostic composition. isolating the nucleic acid molecule from the subject's biological sample;
detecting the expression of a mutant gene consisting of BAP1, CDK4, ERBB2, FGFR3, PTCH1 and TP53 or a mutant protein encoded by the mutant gene from the nucleic acid molecule; and
When the mutant gene or mutant protein is detected, there is a possibility of developing ovarian cancer or determining that ovarian cancer has been invented
A method of providing information necessary for predicting or diagnosing the onset of ovarian cancer, comprising a. 8. The method of claim 7,
The method, wherein the nucleic acid molecule is cell-free circulating DNA (cfDNA), circulating tumor cell DNA (ctcDNA), or a combination thereof. 8. The method of claim 7,
The mutant gene consisting of BAP1, CDK4, ERBB2, FGFR3, PTCH1 and TP53 is a polynucleotide comprising a BAP1 mutation consisting of a polynucleotide in which base T at position 548 is substituted with C in the polynucleotide consisting of the sequence of SEQ ID NO: ;
a polynucleotide comprising a CDK4 mutation consisting of a polynucleotide sequence in which C is inserted between bases 753 and 754 in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 2;
a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1966th base T is substituted with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;
a polynucleotide comprising an ERBB2 mutation consisting of a polynucleotide sequence in which the 1147th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 3;
a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which the 1900th base G is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;
a polynucleotide comprising a FGFR3 mutation consisting of a polynucleotide sequence in which base G at 1672 is substituted with A in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 4;
a polynucleotide comprising a TP53 mutation consisting of a polynucleotide sequence in which the 31st base G is substituted with C in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 5;
a polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 3785 is substituted with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6; and
A method comprising a polynucleotide comprising a PTCH1 mutation consisting of a polynucleotide sequence in which base C at position 37943 is substituted with T in the polynucleotide sequence consisting of the sequence of SEQ ID NO: 6. 8. The method of claim 7,
The mutant protein is a BAP1 mutant protein in which L, which is the 183th amino acid residue in the amino acid sequence of SEQ ID NO: 7, is substituted with P;
CDK4 mutant protein in which the 252th amino acid residue R in the amino acid sequence of SEQ ID NO: 8 is frameshifted;
ERBB2 mutant protein in which S, which is the 656th amino acid residue in the amino acid sequence of SEQ ID NO: 9, is substituted with P;
ERBB2 mutant protein in which G, which is the 383th amino acid residue in the amino acid sequence of SEQ ID NO: 9, is substituted with R;
FGFR3 mutant protein in which A, which is the 634th amino acid residue in the amino acid sequence of SEQ ID NO: 10, is substituted with T;
a FGFR3 mutant protein in which A, which is the 558th amino acid residue in the amino acid sequence of SEQ ID NO: 10, is substituted with T; a TP53 mutant protein in which E, which is the 11th amino acid residue, is substituted with Q in the amino acid sequence of SEQ ID NO: 11;
PTCH1 mutant protein in which P, which is the 1262th amino acid residue in the amino acid sequence of SEQ ID NO: 12, is substituted with L; and
In the amino acid sequence of SEQ ID NO: 12, the method comprising a PTCH1 mutant protein in which the 1315th amino acid residue P is substituted with S. 8. The method of claim 7,
Methods for detecting the mutant gene include next-generation sequencing (NGS), reverse transcription polymerase reaction, competitive reverse transcription polymerase reaction, real-time reverse transcription polymerase reaction, RNase protection assay (RPA), Northern blotting and DNA chip. is selected from the group consisting of. 8. The method of claim 7,
The method of detecting the mutant gene is to detect using a primer or probe that specifically binds to the mutant gene. 8. The method of claim 7,
The method of detecting the mutant protein is to detect using an antibody or aptamer specific for the mutant protein, the method.

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