JP2010530372A5 - - Google Patents

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JP2010530372A5
JP2010530372A5 JP2010512358A JP2010512358A JP2010530372A5 JP 2010530372 A5 JP2010530372 A5 JP 2010530372A5 JP 2010512358 A JP2010512358 A JP 2010512358A JP 2010512358 A JP2010512358 A JP 2010512358A JP 2010530372 A5 JP2010530372 A5 JP 2010530372A5
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JP5539864B2 (ja
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JP2010512358A 2007-06-12 2008-06-12 抗菌剤 Expired - Fee Related JP5539864B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94349407P 2007-06-12 2007-06-12
US60/943,494 2007-06-12
PCT/US2008/066766 WO2008154642A2 (en) 2007-06-12 2008-06-12 Antibacterial agents

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JP2014094451A Division JP2014177468A (ja) 2007-06-12 2014-05-01 抗菌剤

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JP2010530372A JP2010530372A (ja) 2010-09-09
JP2010530372A5 true JP2010530372A5 (cg-RX-API-DMAC7.html) 2011-07-14
JP5539864B2 JP5539864B2 (ja) 2014-07-02

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JP2010512358A Expired - Fee Related JP5539864B2 (ja) 2007-06-12 2008-06-12 抗菌剤
JP2014094451A Pending JP2014177468A (ja) 2007-06-12 2014-05-01 抗菌剤
JP2016231270A Pending JP2017081931A (ja) 2007-06-12 2016-11-29 抗菌剤

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JP2014094451A Pending JP2014177468A (ja) 2007-06-12 2014-05-01 抗菌剤
JP2016231270A Pending JP2017081931A (ja) 2007-06-12 2016-11-29 抗菌剤

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US (3) US20100190766A1 (cg-RX-API-DMAC7.html)
EP (2) EP2662353A3 (cg-RX-API-DMAC7.html)
JP (3) JP5539864B2 (cg-RX-API-DMAC7.html)
CN (2) CN101765585B (cg-RX-API-DMAC7.html)
CA (2) CA2691987C (cg-RX-API-DMAC7.html)
ES (1) ES2602615T3 (cg-RX-API-DMAC7.html)
TW (4) TWI574941B (cg-RX-API-DMAC7.html)
WO (1) WO2008154642A2 (cg-RX-API-DMAC7.html)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5442449B2 (ja) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド 新規化合物
MX2009006706A (es) 2006-12-22 2009-07-02 Astex Therapeutics Ltd Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos.
CN101765585B (zh) * 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2710477A1 (en) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
US8242145B2 (en) 2008-02-14 2012-08-14 Panmira Pharmaceuticals, Llc Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors
US8426449B2 (en) 2008-04-02 2013-04-23 Panmira Pharmaceuticals, Llc Aminoalkylphenyl antagonists of prostaglandin D2 receptors
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
CA2728210A1 (en) * 2008-06-25 2009-12-30 Schering Corporation Synthesis and use of heterocyclic antibacterial agents
TWI403319B (zh) 2008-07-03 2013-08-01 Panmira Pharmaceuticals Llc 前列腺素d2受體之雜烷基拮抗劑
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
US8372885B2 (en) * 2008-09-17 2013-02-12 Novartis Ag Organic compounds and their uses
WO2010057118A2 (en) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
FR2950057B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2950056B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
EP2488502A4 (en) 2009-10-16 2013-05-15 Rib X Pharmaceuticals Inc ANTIMICROBIAL COMPOUNDS AND METHOD FOR THEIR PREPARATION AND USE
CA2777739A1 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CA2777734A1 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
KR20120115989A (ko) 2010-01-06 2012-10-19 판미라 파마슈티칼스, 엘엘씨 Dp2 길항제 및 이의 용도
NZ603198A (en) 2010-04-20 2013-10-25 Taisho Pharmaceutical Co Ltd Novel hydroxamic acid derivative
US8835472B2 (en) * 2010-09-02 2014-09-16 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
WO2012031298A2 (en) 2010-09-03 2012-03-08 Duke University Ethynylbenzene derivatives
TW201249786A (en) * 2010-11-10 2012-12-16 Achaogen Inc Antibacterial agents
SG10201603027QA (en) 2011-04-15 2016-05-30 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
UY34305A (es) 2011-09-01 2013-04-30 Novartis Ag Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
AR087843A1 (es) 2011-09-12 2014-04-23 Achaogen Inc Formas polimorficas de n-((s)-3-amino-1-(hidroxiamino)-3-metil-1-oxobutan-2-il)-4-(((1r,2r)-2-(hidroximetil)ciclopropil)buta-1,3-dinil)benzamida
CN102603690A (zh) * 2012-01-17 2012-07-25 凯莱英医药集团(天津)股份有限公司 一种一锅法制备四氢吡喃-4-甲酸及其衍生物的方法
HK1201817A1 (en) 2012-02-17 2015-09-11 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
WO2013170030A1 (en) * 2012-05-09 2013-11-14 Achaogen, Inc. Antibacterial agents
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
JP6139272B2 (ja) * 2012-06-01 2017-05-31 株式会社半導体エネルギー研究所 発光素子の作製方法
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
PT2975022T (pt) 2013-03-15 2019-06-11 Fujifilm Toyama Chemical Co Ltd Novo derivado de ácido hidroxâmico ou um seu sal
GB201307233D0 (en) * 2013-04-22 2013-05-29 Vib Vzw Compounds and uses thereof
BR112015032902A8 (pt) 2013-07-02 2019-12-24 Millennium Pharm Inc compostos de heteroarila, seus usos e composições farmacêuticas
US10189786B2 (en) 2013-08-16 2019-01-29 Duke University Antibacterial compounds
US9908851B2 (en) 2013-08-16 2018-03-06 Duke University 2-piperidinyl substituted N,3-dihydroxybutanamides
EP3041354A4 (en) 2013-08-16 2017-06-14 Duke University Substituted hydroxamic acid compounds
US9937183B2 (en) 2013-09-09 2018-04-10 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
MX2016002975A (es) 2013-09-09 2016-10-21 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
JP2016210682A (ja) * 2013-10-18 2016-12-15 大正製薬株式会社 ヒドロキサム酸誘導体
TW201602065A (zh) * 2013-10-18 2016-01-16 大正製藥股份有限公司 異羥肟酸衍生物
JP2016210683A (ja) * 2013-10-18 2016-12-15 大正製薬株式会社 ヒドロキサム酸誘導体
ES2666130T3 (es) 2013-12-19 2018-05-03 Idorsia Pharmaceuticals Ltd Derivados antibacterianos de 1H-indazol y 1H-indol
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
WO2015173329A1 (en) * 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
CN106794175B (zh) * 2014-06-12 2020-06-09 西达-赛奈医疗中心 用于治疗癌症的组合物
HRP20191979T1 (hr) 2014-07-01 2020-02-07 Millennium Pharmaceuticals, Inc. Heteoarilni spojevi koji su korisni kao inhibitori sumo-aktivirajućeg enzima
MX2017002967A (es) 2014-09-12 2017-05-30 Toyama Chemical Co Ltd Composicion farmaceutica novedosa que contiene derivado de acido hidroxamico o sal del mismo.
CA2960936A1 (en) 2014-09-12 2016-03-17 Toyama Chemical Co., Ltd. Method for using novel hydroxamic acid derivative and antibacterial substance in combination
CN104262433B (zh) * 2014-10-11 2016-06-15 吉首大学 噁二唑-腺苷型化合物作为TyrRS抑制剂及其制法和用途
CN104231024B (zh) * 2014-10-11 2016-06-15 吉首大学 噁二唑-肌苷型化合物作为TyrRS抑制剂及其制法和用途
CN104341475A (zh) * 2014-10-11 2015-02-11 吉首大学 利奈唑胺-腺苷型多靶点抗菌化合物及其制法和用途
CN104341476A (zh) * 2014-10-11 2015-02-11 吉首大学 利奈唑胺-肌苷型多靶点抗菌化合物及其制法和用途
CN104327140B (zh) * 2014-10-11 2016-06-15 吉首大学 噁唑烷酮-腺苷型多靶点抗菌化合物及其制法和用途
CN105777464B (zh) * 2014-12-26 2020-09-29 中国科学院上海药物研究所 异羟肟酸衍生物及其制备方法和应用
JP6208161B2 (ja) * 2015-02-06 2017-10-04 信越化学工業株式会社 非対称共役ジイン化合物の製造方法及びこれを用いたz,z−共役ジエン化合物の製造方法
WO2016145417A1 (en) 2015-03-11 2016-09-15 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
US10414735B2 (en) 2015-11-09 2019-09-17 Forge Therapeutics, Inc. Substituted hydroxypyrimidinones for treating bacterial infections
US10611747B2 (en) 2015-11-09 2020-04-07 Forge Therapeutics, Inc. Pyrone based compounds for treating bacterial infections
AU2016367510A1 (en) * 2015-12-08 2018-06-07 Glaxosmithkline Intellectual Property Development Limited Substituted benzazinones as antibacterial compounds
CN105669750B (zh) * 2016-03-01 2018-04-03 中国医学科学院医药生物技术研究所 新型锌离子螯合剂及其制备和在抗革兰氏阴性菌感染中的应用
MX2018010878A (es) 2016-03-07 2018-11-09 Merck Sharp & Dohme Compuestos de aril-monobactam biciclicos y metodos de uso de los mismos para el tratamiento de infecciones bacterianas.
EP3426674A4 (en) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
AU2017253625B2 (en) * 2016-04-18 2021-08-12 Vivoryon Therapeutics N.V. Novel inhibitors of meprin alpha and beta
US11034649B2 (en) * 2016-04-25 2021-06-15 Duke University Benzoylglycine derivatives and methods of making and using same
JP2019515041A (ja) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドMelinta Therapeutics, Inc. 抗菌剤ならびにそれを作製および使用する方法
AR108864A1 (es) 2016-06-23 2018-10-03 Achaogen Inc Agentes antibacterianos
EP3481835A4 (en) 2016-07-05 2020-02-26 Blade Therapeutics, Inc. CALPAIN MODULATORS AND THEIR THERAPEUTIC USES
US10934261B2 (en) 2016-09-28 2021-03-02 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
MX388647B (es) 2016-12-23 2025-03-20 Intervet Int Bv Compuestos utiles para el tratamiento de una infeccion por mannheimia haemolytica o histophilus somni.
AR110440A1 (es) 2016-12-23 2019-03-27 Intervet Int Bv Compuestos para el tratamiento de la enfermedad respiratoria bovina o porcina
JP7191298B2 (ja) 2017-04-26 2022-12-19 バジリア・ファルマスーチカ・インターナショナル・アーゲー,アルシュヴィル フラザノベンズイミダゾール類及びその結晶形の調製方法
WO2018208987A2 (en) * 2017-05-10 2018-11-15 Forge Therapeutics, Inc. Antibacterial compounds
US11021471B2 (en) 2017-05-10 2021-06-01 Forge Therapeutics, Inc. Antibacterial compounds
US11351126B2 (en) * 2017-07-27 2022-06-07 BioMendics, LLC Substituted tolans for the modulation of microbial colonization
KR20200049797A (ko) * 2017-08-21 2020-05-08 마이크로바이오틱스, 인코포레이티드 항균제로서 유용한 대사 안정적인 n-아실아미노옥사다이아졸
US11498909B2 (en) 2018-02-10 2022-11-15 Kbp Biosciences Co., Ltd. Compound acting as antibiotics
KR20200143376A (ko) 2018-03-13 2020-12-23 샤이어 휴먼 지네틱 테라피즈 인크. 혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도
FI3853234T3 (fi) 2018-09-18 2025-07-28 Nikang Therapeutics Inc Fuusioituja trisyklisiä rengasjohdannaisia SRC-homologia-2-fosfataasin estäjinä
AU2019345150A1 (en) 2018-09-20 2021-05-13 Blacksmith Medicines, Inc. Antibacterial compounds
JP7189369B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ, インコーポレイテッド アルファ4β7インテグリンの阻害のための化合物
JP7189368B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ, インコーポレイテッド アルファ4ベータ7インテグリンの阻害のための化合物
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
CN119462635A (zh) 2018-10-30 2025-02-18 吉利德科学公司 作为α4β7整合素抑制剂的喹啉衍生物
US20220081421A1 (en) * 2018-11-14 2022-03-17 Forge Therapeutics, Inc. Antibacterial compounds
BR112021009536A2 (pt) * 2018-11-21 2021-08-17 Taisho Pharmaceutical Co., Ltd. derivado de imidazol
KR20220047323A (ko) 2019-08-14 2022-04-15 길리애드 사이언시즈, 인코포레이티드 알파 4 베타 7 인테그린의 저해용 화합물
CN114728962B (zh) 2019-09-18 2025-09-19 武田药品工业有限公司 血浆激肽释放酶抑制剂及其用途
US11370803B2 (en) 2019-09-18 2022-06-28 Takeda Pharmaceutical Company Limited Heteroaryl plasma kallikrein inhibitors
CN110563611B (zh) * 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用
WO2021138391A1 (en) 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Indazole compounds
WO2021195260A1 (en) 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor and methods of making
BR112022025037A2 (pt) 2020-06-10 2023-02-14 Aligos Therapeutics Inc Compostos antivirais para tratar infecções por coronavírus, picornavírus e norovírus
MA63501B1 (fr) 2021-06-14 2024-07-31 Scorpion Therapeutics, Inc. Dérivés d'urée pouvant être utilisés pour traiter le cancer
AU2022306289A1 (en) 2021-07-09 2024-01-18 Aligos Therapeutics, Inc. Anti-viral compounds
WO2023011573A1 (zh) * 2021-08-05 2023-02-09 浙江海正药业股份有限公司 芳香乙炔类衍生物及其制备方法和用途
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CA3233328A1 (en) 2021-09-28 2023-04-06 Min Teng Lpxc inhibitors and uses thereof
WO2023118558A1 (en) * 2021-12-24 2023-06-29 Intervet International B.V. Process of the preparation of hydroxylamine derivatives
WO2024067813A1 (zh) * 2022-09-28 2024-04-04 浙江海正药业股份有限公司 芳香乙炔类衍生物及其制备方法和其医药上的用途
CN115480037B (zh) * 2022-10-14 2023-07-18 青岛国泰检测科技有限公司 一种污水检测方法
CN115598253B (zh) * 2022-10-25 2025-02-21 无锡紫杉药业股份有限公司 一种多西他赛原料药中dcc和dcu残留的检测方法
WO2024127350A1 (en) 2022-12-16 2024-06-20 Astrazeneca Ab 2,6,9-trisubstituted purines
CN117586278A (zh) * 2023-11-27 2024-02-23 华北制药集团先泰药业有限公司 一种氨苄西林钠杂质及其制备方法
WO2025155681A1 (en) * 2024-01-19 2025-07-24 Corteva Agriscience Llc Nitrification inhibiting mixtures

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3167476A (en) * 1965-01-26 preparations acting on the central nervous
US85369A (en) * 1868-12-29 Improved railway-car brake
US2772281A (en) * 1954-12-23 1956-11-27 Merck & Co Inc Synthesis of 4-amino-3-isoxazolidone and its derivatives
DE2441261A1 (de) * 1974-08-28 1976-03-18 Merck Patent Gmbh Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung
US4077998A (en) * 1975-10-28 1978-03-07 Morton-Norwich Products, Inc. Phthaloyl amino acid hydroxamic acids
US4613616A (en) * 1984-07-20 1986-09-23 Research Corporation Polymeric iron chelators
JPS6187693A (ja) * 1984-10-05 1986-05-06 Fuji Yakuhin Kogyo Kk ペプチジルヒドロキサム酸誘導体およびそれを含有するウレア−ゼ活性阻害剤
US5214204A (en) * 1991-07-19 1993-05-25 Abbott Laboratories Arylamidoalkyl-n-hydroxyurea compounds having lipoxygenase inhibitory activity
GB9503749D0 (en) 1995-02-24 1995-04-12 British Biotech Pharm Synthesis of hydroxamic acid derivatives
MX9800710A (es) 1995-07-26 1998-04-30 Pfizer Derivados de n-(aroil) glicina acido hidroxamico y compuestos relacionados.
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
WO1998015525A1 (en) 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Hydroxamic acids
US6281245B1 (en) 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
US6541276B2 (en) 1996-10-28 2003-04-01 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
AR016751A1 (es) 1996-11-22 2001-08-01 Athena Neurosciences Inc Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo
GB9715030D0 (en) * 1997-07-18 1997-09-24 British Biotech Pharm Metalloproteinase inhibitors
CA2298617A1 (en) * 1997-07-31 1999-02-11 Yetunde Olabisi Taiwo Acyclic metalloprotease inhibitors
EP1024134A4 (en) 1997-10-09 2003-05-14 Ono Pharmaceutical Co DERIVATIVES OF AMINOBUTANIC ACID
NZ505675A (en) 1998-02-07 2002-11-26 British Biotech Pharm N-alkylamide substituted hydroxamic acid derivatives are used as antibacterial agents
US5952537A (en) 1998-03-13 1999-09-14 Wiley Organics, Inc. Preparation of cycloalkylacetylene compounds using dialkylaminomagnesium halide or bis(dialkylamino)magnesium
WO2000002904A1 (en) 1998-07-08 2000-01-20 Harald Tschesche Matrix metalloproteinase inhibitors containing aminomalonic acid derivatives and peptide backbone modified derivatives thereof
GB9901863D0 (en) 1999-01-29 1999-03-17 British Biotech Pharm Antibacterial agents
CA2366264A1 (en) 1999-04-02 2000-10-12 Bristol-Myers Squibb Company Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase
EP1169031A1 (en) 1999-04-09 2002-01-09 British Biotech Pharmaceuticals Limited Antimicrobial agents
US6699899B1 (en) * 1999-12-21 2004-03-02 Celgene Corporation Substituted acylhydroxamic acids and method of reducing TNFα levels
IL151018A0 (en) * 2000-03-17 2003-02-12 Bristol Myers Squibb Pharma Co Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
DE60143520D1 (de) * 2000-03-24 2011-01-05 Methylgene Inc Inhibitoren der histon-deacetylase
DE60115279T2 (de) 2000-09-29 2006-12-28 Topotarget Uk Ltd., Abingdon Carbaminsäurederivate enthaltend eine amidgruppe als hdac-inhibitoren
WO2002030873A1 (en) 2000-10-10 2002-04-18 Fujisawa Pharmaceutical Co., Ltd. Mmp inhibitor
EP1343753A2 (en) 2000-12-21 2003-09-17 De Novo Pharmaceuticals Ltd. Antimicrobial agents
AR035417A1 (es) * 2001-01-27 2004-05-26 Hoffmann La Roche Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos
JPWO2002074298A1 (ja) * 2001-03-21 2004-07-08 小野薬品工業株式会社 Il−6産生阻害剤
US6436933B1 (en) * 2001-03-26 2002-08-20 Structural Bioinformatics Inc. Inhibitors of anthrax lethal factor activity
US6852882B2 (en) * 2001-06-05 2005-02-08 Smithkline Beecham Corporation Peptide deformylase inhibitors
EP1401831A1 (en) 2001-07-03 2004-03-31 Chiron Corporation Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
PL370176A1 (en) * 2001-11-13 2005-05-16 3-Dimensional Pharmaceuticals, Inc. Substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
PL374117A1 (en) * 2002-05-29 2005-10-03 Merck & Co, Inc. Compounds useful in the treatment of anthrax and inhibiting lethal factor
KR101011373B1 (ko) * 2002-07-11 2011-01-28 비큐론 파마슈티컬스 인코포레이티드 항균작용을 갖는 n-히드록시아미드 유도체
US7282608B2 (en) 2002-10-17 2007-10-16 Methylgene, Inc. Inhibitors of histone deacetylase
JP2004143053A (ja) * 2002-10-22 2004-05-20 Senju Pharmaceut Co Ltd β−アミノヒドロキサム酸誘導体およびその用途
JP5269281B2 (ja) * 2002-12-30 2013-08-21 セルジーン コーポレイション フルオロアルコキシ置換1,3−ジヒドロイソインドリル化合物およびそれらの医薬としての使用
SG2012000667A (en) * 2003-01-08 2015-03-30 Univ Washington Antibacterial agents
US20040155210A1 (en) * 2003-02-07 2004-08-12 Wears William E. Instrument mounting apparatus for a fluid control valve
EP1605896B1 (en) * 2003-03-12 2013-09-18 Celgene Corporation 7-amino- isoindolyl compounds amd their pharmaceutical uses
WO2004110989A1 (en) * 2003-05-14 2004-12-23 Bayer Pharmaceuticals Corporation N-hydroxy-7-(arylamino)heptanamide derivatives useful for treating hyper-proliferative disorders
WO2006106440A1 (en) * 2005-01-14 2006-10-12 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Macrolide compounds containing biotin and photo-affinity group for macrolide target identification
GT200600196A (es) 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
BRPI0611694A2 (pt) * 2005-06-07 2010-09-28 Novartis Ag inibidores peptìdicos da deformilase 4 (pdf)
US20070066646A1 (en) * 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof
KR20080070876A (ko) 2005-12-01 2008-07-31 쉐링 코포레이션 염증 질환 및 미생물 질병 치료용 조성물
WO2007069020A2 (en) 2005-12-15 2007-06-21 Vicuron Pharmaceuticals Inc. N-hydroxyamide derivatives possessing antibacterial activity
US7998961B2 (en) 2006-08-31 2011-08-16 Schering Corporation Hydantoin derivatives useful as antibacterial agents
CN101209974A (zh) 2006-12-31 2008-07-02 天津药物研究院 异羟肟酸类衍生物及其用途
WO2008105515A1 (ja) 2007-02-28 2008-09-04 Taisho Pharmaceutical Co., Ltd. 新規なヒドロキサム酸誘導体
CN101765585B (zh) * 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂
CA2728210A1 (en) 2008-06-25 2009-12-30 Schering Corporation Synthesis and use of heterocyclic antibacterial agents
AU2009279949A1 (en) 2008-08-04 2010-02-11 Merck Sharp & Dohme Corp. Urea derivatives as antibacterial agents
JP5455913B2 (ja) 2008-08-27 2014-03-26 大正製薬株式会社 ナフチリジン−n−オキシドを有する新規ヒドロキサム酸誘導体
US8372885B2 (en) * 2008-09-17 2013-02-12 Novartis Ag Organic compounds and their uses
EP2334636A2 (en) 2008-09-19 2011-06-22 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
WO2011045703A2 (en) 2009-10-13 2011-04-21 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
WO2011073845A1 (en) 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
NZ603198A (en) 2010-04-20 2013-10-25 Taisho Pharmaceutical Co Ltd Novel hydroxamic acid derivative
TW201249786A (en) 2010-11-10 2012-12-16 Achaogen Inc Antibacterial agents
AR087843A1 (es) 2011-09-12 2014-04-23 Achaogen Inc Formas polimorficas de n-((s)-3-amino-1-(hidroxiamino)-3-metil-1-oxobutan-2-il)-4-(((1r,2r)-2-(hidroximetil)ciclopropil)buta-1,3-dinil)benzamida
WO2013170030A1 (en) 2012-05-09 2013-11-14 Achaogen, Inc. Antibacterial agents
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents

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