DK3164130T3 - Heteroaryle forbindelser anvendelige som inhibatorer af sumo-aktiverende enzym - Google Patents
Heteroaryle forbindelser anvendelige som inhibatorer af sumo-aktiverende enzym Download PDFInfo
- Publication number
- DK3164130T3 DK3164130T3 DK15815330T DK15815330T DK3164130T3 DK 3164130 T3 DK3164130 T3 DK 3164130T3 DK 15815330 T DK15815330 T DK 15815330T DK 15815330 T DK15815330 T DK 15815330T DK 3164130 T3 DK3164130 T3 DK 3164130T3
- Authority
- DK
- Denmark
- Prior art keywords
- sumo
- inhibitors
- compounds useful
- activating enzyme
- heteroaryl compounds
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 0 CCCCNC*(C)=C Chemical compound CCCCNC*(C)=C 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/535—Organo-phosphoranes
- C07F9/5352—Phosphoranes containing the structure P=C-
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462019756P | 2014-07-01 | 2014-07-01 | |
US201562185678P | 2015-06-28 | 2015-06-28 | |
PCT/US2015/038712 WO2016004136A1 (en) | 2014-07-01 | 2015-06-30 | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3164130T3 true DK3164130T3 (da) | 2019-10-28 |
Family
ID=55019950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15815330T DK3164130T3 (da) | 2014-07-01 | 2015-06-30 | Heteroaryle forbindelser anvendelige som inhibatorer af sumo-aktiverende enzym |
Country Status (38)
Country | Link |
---|---|
US (6) | US9683003B2 (da) |
EP (3) | EP3164130B1 (da) |
JP (4) | JP6603712B2 (da) |
KR (1) | KR102491125B1 (da) |
CN (1) | CN106999479B (da) |
AU (1) | AU2015284135B2 (da) |
BR (1) | BR112016030787B1 (da) |
CA (1) | CA2953132C (da) |
CL (1) | CL2016003398A1 (da) |
CR (1) | CR20170021A (da) |
CY (1) | CY1122808T1 (da) |
DK (1) | DK3164130T3 (da) |
DO (1) | DOP2016000339A (da) |
EA (1) | EA034119B1 (da) |
EC (1) | ECSP17006751A (da) |
ES (1) | ES2754359T3 (da) |
GE (1) | GEP20197047B (da) |
HR (1) | HRP20191979T1 (da) |
HU (1) | HUE045748T2 (da) |
IL (1) | IL249820B (da) |
LT (1) | LT3164130T (da) |
ME (1) | ME03574B (da) |
MX (1) | MX2016016993A (da) |
MY (1) | MY183649A (da) |
NZ (1) | NZ728162A (da) |
PE (1) | PE20170520A1 (da) |
PH (1) | PH12016502595A1 (da) |
PL (1) | PL3164130T3 (da) |
PT (1) | PT3164130T (da) |
RS (1) | RS59474B1 (da) |
SG (1) | SG11201610476VA (da) |
SI (1) | SI3164130T1 (da) |
TN (1) | TN2016000581A1 (da) |
TW (1) | TWI680970B (da) |
UA (1) | UA122963C2 (da) |
UY (1) | UY36198A (da) |
WO (1) | WO2016004136A1 (da) |
ZA (1) | ZA201700386B (da) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2739150T3 (es) | 2012-02-17 | 2020-01-29 | Millennium Pharm Inc | Inhibidores de pirazolopirimidinilo de la enzima activadora de ubiquitina |
US9593121B2 (en) | 2012-08-03 | 2017-03-14 | Millennium Pharmaceuticals, Inc. | Indole substituted pyrrolopyrimidinyl inhibitors of Uba6 |
AU2015284135B2 (en) | 2014-07-01 | 2019-11-28 | Takeda Pharmaceutical Company Limited | Heteroaryl compounds useful as inhibitors of SUMO activating enzyme |
US10465447B2 (en) | 2015-03-12 | 2019-11-05 | Baker Hughes, A Ge Company, Llc | Cutting elements configured to mitigate diamond table failure, earth-boring tools including such cutting elements, and related methods |
TWI791251B (zh) | 2015-08-26 | 2023-02-01 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
MX2019003843A (es) | 2016-10-03 | 2019-06-24 | Janssen Pharmaceutica Nv | Análogos novedosos de carbanucleósidos sustituidos de sistema anular monocíclico y bicíclico para su uso como inhibidores de prmt5. |
BR112019017466A2 (pt) | 2017-02-27 | 2020-03-31 | Janssen Pharmaceutica Nv | Uso de biomarcadores na identificação de pacientes com câncer que serão responsivos a tratamento com um inibidor de prmt5 |
WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
US10400517B2 (en) | 2017-05-02 | 2019-09-03 | Baker Hughes, A Ge Company, Llc | Cutting elements configured to reduce impact damage and related tools and methods |
US11124519B2 (en) | 2017-09-21 | 2021-09-21 | Millennium Pharmaceuticals, Inc. | Cocrystal forms of ((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl) methyl sulfamate, formulations and uses thereof |
MA51004A (fr) | 2017-12-08 | 2020-10-14 | Janssen Pharmaceutica Nv | Nouveaux analogues spirobicycliques |
EP4242212A3 (en) | 2018-03-23 | 2023-11-15 | Takeda Pharmaceutical Company Limited | Sting modulator compounds with sulfamate linkages, and methods of making and using |
CN112312904A (zh) * | 2018-04-16 | 2021-02-02 | C4医药公司 | 螺环化合物 |
CN112384219A (zh) * | 2018-07-09 | 2021-02-19 | 千禧制药公司 | Sumo-激活酶抑制剂和抗cd20抗体的施用 |
US10570668B2 (en) | 2018-07-27 | 2020-02-25 | Baker Hughes, A Ge Company, Llc | Cutting elements configured to reduce impact damage and mitigate polycrystalline, superabrasive material failure earth-boring tools including such cutting elements, and related methods |
CN109354569A (zh) * | 2018-11-27 | 2019-02-19 | 常州大学 | 一种1,3-二溴-4-氟苯的制备方法 |
EP3930720A4 (en) * | 2019-02-26 | 2022-12-28 | Millennium Pharmaceuticals, Inc. | COMPOUNDS USEFUL AS ADJUVANTS |
AU2020228385A1 (en) * | 2019-02-27 | 2021-07-29 | Takeda Pharmaceutical Company Limited | Administration of sumo-activating enzyme inhibitor and checkpoint inhibitors |
TW202112375A (zh) | 2019-06-06 | 2021-04-01 | 比利時商健生藥品公司 | 使用prmt5抑制劑治療癌症之方法 |
EP3782702A1 (en) * | 2019-08-21 | 2021-02-24 | AC BioScience SA | Compounds and use thereof for the treatment of infectious diseases and cancer |
CN112402608B (zh) * | 2020-11-30 | 2021-09-07 | 深圳先进技术研究院 | 5-烷氧基吲哚-3-乙烯基喹啉盐作为靶向可迁移光敏剂的应用 |
WO2021203001A1 (en) * | 2020-04-03 | 2021-10-07 | Millennium Pharmaceuticals, Inc. | Method of treating patients infected with a viral infection with an inhibitor of small ubiquitin like modifier activating enzyme |
MX2022014297A (es) * | 2020-05-15 | 2023-02-09 | Takeda Pharmaceuticals Co | Administración del inhibidor de la enzima activadora (sae) del modificador similar a la ubiquitina pequeña (sumo) y anticuerpos anti cúmulo de diferenciación 38 (cd38). |
CN113173852B (zh) * | 2021-04-26 | 2022-07-12 | 深圳市华先医药科技有限公司 | 二氟丙二酸酯类化合物的制备方法 |
WO2023073645A1 (en) | 2021-10-29 | 2023-05-04 | Takeda Pharmaceutical Company Limited | Therapy comprising anti-cd19 antibody and sumo-activating enzyme inhibitor |
US11920409B2 (en) | 2022-07-05 | 2024-03-05 | Baker Hughes Oilfield Operations Llc | Cutting elements, earth-boring tools including the cutting elements, and methods of forming the earth-boring tools |
WO2024067676A1 (zh) * | 2022-09-30 | 2024-04-04 | 微境生物医药科技(上海)有限公司 | 作为sumo活化酶抑制剂的化合物 |
WO2024099438A1 (zh) * | 2022-11-11 | 2024-05-16 | 微境生物医药科技(上海)有限公司 | 作为sumo活化酶抑制剂的化合物 |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194446A (en) | 1989-06-12 | 1993-03-16 | A. H. Robins Company, Incorporated | Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals |
WO1997005132A1 (en) | 1995-07-28 | 1997-02-13 | Cubist Pharmaceuticals, Inc. | Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents |
WO2003073989A2 (en) | 2002-02-28 | 2003-09-12 | Biota, Inc. | Nucleoside 5'-monophosphate mimics and their prodrugs |
US7527966B2 (en) | 2002-06-26 | 2009-05-05 | Transgenrx, Inc. | Gene regulation in transgenic animals using a transposon-based vector |
CA2493816A1 (en) | 2002-07-24 | 2004-01-29 | Ptc Therapeutics, Inc. | Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases |
US7291603B2 (en) | 2002-07-24 | 2007-11-06 | Ptc Therapeutics, Inc. | Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations |
US7563798B2 (en) | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
CN1701073B (zh) | 2002-09-04 | 2011-06-22 | 先灵公司 | 作为细胞周期蛋白依赖激酶抑制剂的吡唑并[1,5-a]嘧啶 |
US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
ES2285164T3 (es) | 2002-09-04 | 2007-11-16 | Schering Corporation | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. |
AU2003291024A1 (en) | 2002-11-13 | 2004-06-03 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
US7157455B2 (en) * | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
WO2004087707A1 (en) | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
JP2005008581A (ja) | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ[1,5−a]ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
EP1680431A1 (en) | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors |
JPWO2005051949A1 (ja) | 2003-11-26 | 2007-06-21 | 住友製薬株式会社 | 新規縮合イミダゾール誘導体 |
WO2006002284A1 (en) | 2004-06-22 | 2006-01-05 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
US7951810B2 (en) | 2005-02-04 | 2011-05-31 | Millennium Pharmaceuticals, Inc. | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes |
CA2624826A1 (en) | 2005-10-06 | 2007-04-19 | Schering Corporation | Pyrazolopyrimidines as protein kinase inhibitors |
SG169369A1 (en) | 2006-02-02 | 2011-03-30 | Millennium Pharm Inc | Inhibitors of e1 activating enzymes |
US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
BRPI0715176A8 (pt) * | 2006-08-08 | 2018-04-10 | Millennium Pharm Inc | compostos de heteroarila utéis como inibidores de enzimas de ativação e1 |
EP2170814B1 (en) | 2007-06-12 | 2016-08-17 | Achaogen, Inc. | Antibacterial agents |
CA2695193C (en) | 2007-08-02 | 2018-07-17 | Ian Armitage | Process for the synthesis of e1 activating enzyme inhibitors |
US9216983B2 (en) | 2007-12-21 | 2015-12-22 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
US8697694B2 (en) | 2008-08-20 | 2014-04-15 | Merck Sharp & Dohme Corp. | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
AR072939A1 (es) | 2008-08-20 | 2010-09-29 | Schering Corp | Derivados de piridina y pirimidina sustituidas con etenilo y su uso en el tratamiento de infecciones virales |
EP2326628A1 (en) | 2008-08-20 | 2011-06-01 | Schering Corporation | Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
AR072940A1 (es) | 2008-08-20 | 2010-09-29 | Schering Corp | Derivados de piridina y pirimidina sustituidos con etinilo y su uso en el tratamiento de infecciones virales |
EP2342616A2 (en) | 2008-09-23 | 2011-07-13 | Alnylam Pharmaceuticals Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
WO2010088518A2 (en) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
JP2012526808A (ja) | 2009-05-14 | 2012-11-01 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | ((1s,2s,4r)−4−{4−[(1s)−2,3−ジヒドロ−1h−インデン−1−イルアミノ]−7h−ピロロ[2,3−d]ピリミジン−7−イル}−2−ヒドロキシシクロペンチル)スルファミン酸メチルの塩酸塩 |
KR101906146B1 (ko) | 2009-08-17 | 2018-10-10 | 메모리얼 슬로안-케터링 캔서 센터 | 열 충격 단백질 결합 화합물, 조성물, 및 이의 제조 방법 및 사용 방법 |
US9198972B2 (en) | 2010-01-28 | 2015-12-01 | Alnylam Pharmaceuticals, Inc. | Monomers and oligonucleotides comprising cycloaddition adduct(s) |
EP2536410B1 (en) | 2010-02-18 | 2015-09-23 | Merck Sharp & Dohme Corp. | Substituted pyrimidine derivatives and their use in treating viral infections |
EP3064204A1 (en) | 2010-03-01 | 2016-09-07 | GTx, Inc. | Compounds for treatment of cancer |
US8791136B2 (en) | 2010-07-29 | 2014-07-29 | Rigel Pharmaceuticals, Inc. | Substituted pyridine, pyridazine, pyrazine and pyrimidine compounds and methods for using the same |
US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
UA114894C2 (uk) | 2011-08-24 | 2017-08-28 | Мілленніум Фармасьютікалз, Інк. | Інгібітори nedd8-активуючого ферменту |
EP2773207B1 (en) | 2011-10-31 | 2018-03-07 | Merck Sharp & Dohme Corp. | Aminopyrimidinones as interleukin receptor-associated kinase inhibitors |
ES2739150T3 (es) * | 2012-02-17 | 2020-01-29 | Millennium Pharm Inc | Inhibidores de pirazolopirimidinilo de la enzima activadora de ubiquitina |
US20150057243A1 (en) | 2012-04-02 | 2015-02-26 | Northern University | Compositions and Methods for the Inhibition of Methyltransferases |
US9695154B2 (en) * | 2013-07-02 | 2017-07-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl inhibitors of sumo activating enzyme |
US20150087673A1 (en) | 2013-09-26 | 2015-03-26 | Rigel Pharmaceuticals, Inc. | Methods for using and biomarkers for ampk-activating compounds |
LT3060550T (lt) | 2013-10-21 | 2019-08-12 | Merck Patent Gmbh | Heteroarilo junginiai, kaip btk inhibitoriai, ir jų panaudojimas |
WO2015110999A1 (en) | 2014-01-24 | 2015-07-30 | Piramal Enterprises Limited | Ezh2 inhibitors and uses thereof |
AU2015284135B2 (en) | 2014-07-01 | 2019-11-28 | Takeda Pharmaceutical Company Limited | Heteroaryl compounds useful as inhibitors of SUMO activating enzyme |
-
2015
- 2015-06-30 AU AU2015284135A patent/AU2015284135B2/en active Active
- 2015-06-30 SG SG11201610476VA patent/SG11201610476VA/en unknown
- 2015-06-30 MY MYPI2016704774A patent/MY183649A/en unknown
- 2015-06-30 ES ES15815330T patent/ES2754359T3/es active Active
- 2015-06-30 CR CR20170021A patent/CR20170021A/es unknown
- 2015-06-30 EP EP15815330.4A patent/EP3164130B1/en active Active
- 2015-06-30 US US14/788,675 patent/US9683003B2/en active Active
- 2015-06-30 EP EP21165701.0A patent/EP3901159A1/en not_active Withdrawn
- 2015-06-30 PT PT158153304T patent/PT3164130T/pt unknown
- 2015-06-30 KR KR1020177002906A patent/KR102491125B1/ko active IP Right Grant
- 2015-06-30 UA UAA201700861A patent/UA122963C2/uk unknown
- 2015-06-30 DK DK15815330T patent/DK3164130T3/da active
- 2015-06-30 MX MX2016016993A patent/MX2016016993A/es active IP Right Grant
- 2015-06-30 CA CA2953132A patent/CA2953132C/en active Active
- 2015-06-30 JP JP2017521031A patent/JP6603712B2/ja active Active
- 2015-06-30 ME MEP-2019-312A patent/ME03574B/me unknown
- 2015-06-30 SI SI201530976T patent/SI3164130T1/sl unknown
- 2015-06-30 HU HUE15815330A patent/HUE045748T2/hu unknown
- 2015-06-30 BR BR112016030787-9A patent/BR112016030787B1/pt active IP Right Grant
- 2015-06-30 PE PE2016002800A patent/PE20170520A1/es unknown
- 2015-06-30 GE GEAP201514395A patent/GEP20197047B/en unknown
- 2015-06-30 NZ NZ728162A patent/NZ728162A/en unknown
- 2015-06-30 PL PL15815330T patent/PL3164130T3/pl unknown
- 2015-06-30 EP EP19153547.5A patent/EP3517112B1/en active Active
- 2015-06-30 TN TN2016000581A patent/TN2016000581A1/en unknown
- 2015-06-30 UY UY0001036198A patent/UY36198A/es not_active Application Discontinuation
- 2015-06-30 EA EA201790108A patent/EA034119B1/ru not_active IP Right Cessation
- 2015-06-30 RS RS20191405A patent/RS59474B1/sr unknown
- 2015-06-30 WO PCT/US2015/038712 patent/WO2016004136A1/en active Application Filing
- 2015-06-30 TW TW104121240A patent/TWI680970B/zh active
- 2015-06-30 CN CN201580044952.6A patent/CN106999479B/zh active Active
- 2015-06-30 LT LT15815330T patent/LT3164130T/lt unknown
-
2016
- 2016-12-22 PH PH12016502595A patent/PH12016502595A1/en unknown
- 2016-12-26 IL IL249820A patent/IL249820B/en active IP Right Grant
- 2016-12-28 DO DO2016000339A patent/DOP2016000339A/es unknown
- 2016-12-29 CL CL2016003398A patent/CL2016003398A1/es unknown
-
2017
- 2017-01-17 ZA ZA2017/00386A patent/ZA201700386B/en unknown
- 2017-02-01 EC ECIEPI20176751A patent/ECSP17006751A/es unknown
- 2017-04-17 US US15/488,795 patent/US9962386B2/en active Active
-
2018
- 2018-03-16 US US15/923,015 patent/US10335410B2/en active Active
-
2019
- 2019-04-23 US US16/391,534 patent/US10780090B2/en active Active
- 2019-10-11 JP JP2019187426A patent/JP2020023538A/ja not_active Withdrawn
- 2019-10-31 HR HRP20191979TT patent/HRP20191979T1/hr unknown
- 2019-11-05 CY CY20191101149T patent/CY1122808T1/el unknown
-
2020
- 2020-07-10 US US16/926,059 patent/US20220331316A1/en not_active Abandoned
-
2021
- 2021-08-13 JP JP2021131914A patent/JP2021178869A/ja active Pending
-
2022
- 2022-10-11 US US18/045,748 patent/US20230293522A1/en not_active Abandoned
-
2023
- 2023-11-09 JP JP2023191459A patent/JP2024012558A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3164130T3 (da) | Heteroaryle forbindelser anvendelige som inhibatorer af sumo-aktiverende enzym | |
DK3442980T3 (da) | Heterocykliske forbindelser som ret-kinase-hæmmere | |
DK3371190T3 (da) | Heterocykliske forbindelser som pi3k-gamma-inhibitorer | |
DK3377488T3 (da) | Heterocykliske forbindelser som immunomodulatorer | |
DK3371171T3 (da) | Inhibitorer af RET | |
DK3442947T3 (da) | Aminsubstituerede aryl- eller heteroarylforbindelser som ehmt1- og ehmt2-hæmmere | |
DK3277677T3 (da) | 1-cyano-pyrrolidinforbindelser som usp30-hæmmere | |
DK3102576T3 (da) | Dihydropyrrolopyridininhibitorer af ror-gamma | |
DK3556752T3 (da) | N-((het)arylmethyl)-heteroaryl-carboxamidforbindelser som plasmakallikreininhibitorer | |
DK3298002T3 (da) | Heterocykliske amider som kinasehæmmere | |
DK3221306T3 (da) | Heteroarylforbindelser som irak-inhibitorer og anvendelser deraf | |
DK3302448T3 (da) | Erstattede heterocyclylafledninger som cdk-inhibitore | |
DK3105218T3 (da) | Cyclopropylaminer som lsd1-inhibitorer | |
DK3105226T3 (da) | Cyclopropylaminer som lsd1-inhibitorer | |
DK3160956T3 (da) | Inhibitorer af lysin-specifik demethylase-1 | |
DK3119772T3 (da) | Heteroaryl syk-hæmmere | |
DK3536685T3 (da) | Bicyklisk-fusionerede heteroaryl- eller arylforbindelser og anvendelse deraf som irak4 inhibitorer | |
DK3164380T3 (da) | Hæmmere af lysinspecifik demethylase-1 | |
DK3119884T3 (da) | Serinproteaser af bacillus-arter | |
DK3356345T3 (da) | Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer | |
DK3201361T3 (da) | Fremgangsmåder til kvantificering af cellefrit DNA | |
DK3348556T3 (da) | Heteroarylamider som hæmmere af proteinaggregering | |
DK3204378T3 (da) | N-pyridinylacetamidderivater som hæmmere af wnt-signaleringsbanen | |
DK3116475T3 (da) | Dopa-decarboxylasehæmmersammensætninger | |
DK3233843T3 (da) | Isoxazol-hydraxamsyreforbindelser som LPXC-hæmmere |