BR0109469A - Compostos derivados de b-aminoácidos, composição farmacêutica, método para o tratamento ou prevenção de disfunções inflamatórias, método para o tratamento de condições ou doenças mediadas por mmps, tnf, aggrecanase ou uma combinação destes em mamìferos e uso do composto - Google Patents

Compostos derivados de b-aminoácidos, composição farmacêutica, método para o tratamento ou prevenção de disfunções inflamatórias, método para o tratamento de condições ou doenças mediadas por mmps, tnf, aggrecanase ou uma combinação destes em mamìferos e uso do composto

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Publication number
BR0109469A
BR0109469A BR0109469-6A BR0109469A BR0109469A BR 0109469 A BR0109469 A BR 0109469A BR 0109469 A BR0109469 A BR 0109469A BR 0109469 A BR0109469 A BR 0109469A
Authority
BR
Brazil
Prior art keywords
treating
tnf
amino acid
pharmaceutical composition
inflammatory disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
BR0109469-6A
Other languages
English (en)
Inventor
Jingwu Duan
Bryan W King
Carl Decicco
Thomas P Maduskuie Jr
Matthew E Voss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol-Myers Co
Bristol-Myers Squibb Co
Original Assignee
Bristol-Myers Co
Bristol-Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Co, Bristol-Myers Squibb Co filed Critical Bristol-Myers Co
Publication of BR0109469A publication Critical patent/BR0109469A/pt
Pending legal-status Critical Current

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Abstract

"COMPOSTOS DERIVADOS DE <225>-AMINOáCIDOS, COMPOSIçãO FARMACêUTICA, MéTODO PARA O TRATAMENTO OU PREVENçãO DE DISFUNçõES INFLAMATóRIAS, MéTODO PARA O TRATAMENTO DE CONDIçõES OU DOENçAS MEDIADAS POR MMPS, TNF, AGGRECANASE OU UMA COMBINAçãO DESTES EM MAMìFEROS E USO DO COMPOSTO". O presente pedido descreve derivados de ácidos <225>-aminoácidos inovadores da fórmula (I) ou suas formas de sais ou pró-drogas farmaceuticamente aceitáveis, em que A, X, Z, U^ a^, X^ a^, Y^ a^, Z^ a^, R^ 1^, R^ 2^, R^ 3^, R^ 4^ e R^ 4a^ são definidos no presente relatório descritivo, que são úteis como inibidores de metaloprotease e TNF-<224>.
BR0109469-6A 2000-03-17 2001-03-15 Compostos derivados de b-aminoácidos, composição farmacêutica, método para o tratamento ou prevenção de disfunções inflamatórias, método para o tratamento de condições ou doenças mediadas por mmps, tnf, aggrecanase ou uma combinação destes em mamìferos e uso do composto Pending BR0109469A (pt)

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US19018300P 2000-03-17 2000-03-17
US23546700P 2000-09-26 2000-09-26
US25206200P 2000-11-20 2000-11-20
PCT/US2001/008336 WO2001070734A2 (en) 2000-03-17 2001-03-15 Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha

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