JP2018507166A5 - - Google Patents
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- Publication number
- JP2018507166A5 JP2018507166A5 JP2017528877A JP2017528877A JP2018507166A5 JP 2018507166 A5 JP2018507166 A5 JP 2018507166A5 JP 2017528877 A JP2017528877 A JP 2017528877A JP 2017528877 A JP2017528877 A JP 2017528877A JP 2018507166 A5 JP2018507166 A5 JP 2018507166A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibiotic
- conjugate compound
- alkyl
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 230000003115 biocidal effect Effects 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 239000003242 anti bacterial agent Substances 0.000 claims 7
- 229940088710 antibiotic agent Drugs 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004452 carbocyclyl group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000004365 Protease Substances 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 241000191967 Staphylococcus aureus Species 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 125000003003 spiro group Chemical group 0.000 claims 4
- 229930189077 Rifamycin Natural products 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 229960003292 rifamycin Drugs 0.000 claims 3
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000000816 peptidomimetic Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- JUIKUQOUMZUFQT-UHFFFAOYSA-N 2-bromoacetamide Chemical group NC(=O)CBr JUIKUQOUMZUFQT-UHFFFAOYSA-N 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 1
- HAXFWIACAGNFHA-UHFFFAOYSA-N aldrithiol Chemical compound C=1C=CC=NC=1SSC1=CC=CC=N1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical group 0.000 claims 1
- FNXLCIKXHOPCKH-UHFFFAOYSA-N bromamine Chemical group BrN FNXLCIKXHOPCKH-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229960002626 clarithromycin Drugs 0.000 claims 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical group I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical group NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- SGHWBDUXKUSFOP-KYALZUAASA-N rifalazil Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)N=C2C(=O)C=3C(O)=C4C)C)OC)C4=C1C=3C(NC1=C(O)C=3)=C2OC1=CC=3N1CCN(CC(C)C)CC1 SGHWBDUXKUSFOP-KYALZUAASA-N 0.000 claims 1
- 229950005007 rifalazil Drugs 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 150000003573 thiols Chemical group 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical group CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462087213P | 2014-12-03 | 2014-12-03 | |
| US62/087,213 | 2014-12-03 | ||
| PCT/US2015/063515 WO2016090040A1 (en) | 2014-12-03 | 2015-12-02 | Anti-staphylococcus aureus antibody rifamycin conjugates and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018507166A JP2018507166A (ja) | 2018-03-15 |
| JP2018507166A5 true JP2018507166A5 (cg-RX-API-DMAC7.html) | 2019-01-17 |
| JP6751393B2 JP6751393B2 (ja) | 2020-09-02 |
Family
ID=55022690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528877A Expired - Fee Related JP6751393B2 (ja) | 2014-12-03 | 2015-12-02 | 抗ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ抗体リファマイシン抱合体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20180125995A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3226908A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6751393B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170086542A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107249642A (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017011478A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2966211A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1244230A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2017007231A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2017118792A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016090040A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3082875B1 (en) | 2013-12-16 | 2020-11-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| HK1222577A1 (zh) | 2013-12-16 | 2017-07-07 | Genentech Inc. | 擬肽化合物及其抗體藥物偶聯物 |
| WO2016205176A1 (en) | 2015-06-15 | 2016-12-22 | Genentech, Inc. | Antibodies and immunoconjugates |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| AU2016363013B2 (en) | 2015-12-04 | 2022-03-10 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| WO2017152083A1 (en) * | 2016-03-04 | 2017-09-08 | Genentech, Inc. | Process for the preparation of an antibody-rifamycin conjugate |
| KR20190074310A (ko) | 2016-11-08 | 2019-06-27 | 리제너론 파마슈티칼스 인코포레이티드 | 스테로이드 및 이의 단백질-접합체 |
| JP7364471B2 (ja) | 2017-05-18 | 2023-10-18 | レゲネロン ファーマシューティカルス，インコーポレーテッド | シクロデキストリンタンパク質薬物コンジュゲート |
| CA3080857A1 (en) | 2017-11-07 | 2019-05-16 | Regeneron Pharmaceuticals, Inc. | Hydrophilic linkers for antibody drug conjugates |
| MA50259A1 (fr) | 2018-01-08 | 2021-07-29 | Regeneron Pharma | Stéroïdes et leurs conjugués-anticorps |
| CN118955710A (zh) | 2018-05-09 | 2024-11-15 | 里珍纳龙药品有限公司 | 抗msr1抗体及其使用方法 |
| CN111939256B (zh) * | 2020-07-06 | 2022-05-31 | 中国药科大学 | 一种具有细菌调理特性的抗菌辅助材料及其制备方法和应用 |
| US20250082761A1 (en) * | 2021-08-20 | 2025-03-13 | Rutgers, The State University Of New Jersey | Dual-targeted rna polymerase inhibitors: conjugates of benzoxazino- and spiro-rifamycins with n alpha-aroyl-n-aryl-phenylalaninamides |
| US20250319024A1 (en) * | 2021-08-27 | 2025-10-16 | University Of Georgia Research Foundation, Inc. | Targeted nanoparticles and their uses related to infectious disease |
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| HK1222577A1 (zh) * | 2013-12-16 | 2017-07-07 | Genentech Inc. | 擬肽化合物及其抗體藥物偶聯物 |
-
2015
- 2015-12-02 WO PCT/US2015/063515 patent/WO2016090040A1/en not_active Ceased
- 2015-12-02 CN CN201580075250.4A patent/CN107249642A/zh active Pending
- 2015-12-02 KR KR1020177015225A patent/KR20170086542A/ko not_active Withdrawn
- 2015-12-02 RU RU2017118792A patent/RU2017118792A/ru not_active Application Discontinuation
- 2015-12-02 BR BR112017011478-0A patent/BR112017011478A2/pt not_active Application Discontinuation
- 2015-12-02 EP EP15816304.8A patent/EP3226908A1/en not_active Withdrawn
- 2015-12-02 MX MX2017007231A patent/MX2017007231A/es unknown
- 2015-12-02 HK HK18103816.6A patent/HK1244230A1/zh unknown
- 2015-12-02 CA CA2966211A patent/CA2966211A1/en not_active Abandoned
- 2015-12-02 JP JP2017528877A patent/JP6751393B2/ja not_active Expired - Fee Related
-
2017
- 2017-06-02 US US15/612,193 patent/US20180125995A1/en not_active Abandoned
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