|
US3758475A
(en)
|
1971-07-20 |
1973-09-11 |
Sandoz Ag |
Pyrido(2,3-d)pyrimidin 2 ones
|
|
IT1226048B
(it)
|
1981-12-14 |
1990-12-10 |
Medea Res Srl |
Composti ad attivita'antiinfiammatoria, processo per la loro preparazione e composizioni farmaceutiche relative
|
|
DE3263567D1
(en)
|
1981-12-14 |
1985-06-20 |
Medea Res Srl |
New compounds with antiinflammatory and antitussive activity, process for their preparation and relative pharmaceutical compositions
|
|
US4501729A
(en)
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
|
US5304121A
(en)
|
1990-12-28 |
1994-04-19 |
Boston Scientific Corporation |
Drug delivery system making use of a hydrogel polymer coating
|
|
US5981714A
(en)
|
1990-03-05 |
1999-11-09 |
Genzyme Corporation |
Antibodies specific for cystic fibrosis transmembrane conductance regulator and uses therefor
|
|
JP3167762B2
(ja)
|
1990-11-27 |
2001-05-21 |
武田薬品工業株式会社 |
ピリドピリダジン誘導体およびその用途
|
|
US5612360A
(en)
|
1992-06-03 |
1997-03-18 |
Eli Lilly And Company |
Angiotensin II antagonists
|
|
CA2107196A1
(en)
|
1992-09-29 |
1994-03-30 |
Mitsubishi Chemical Corporation |
Carboxamide derivatives
|
|
US5994341A
(en)
|
1993-07-19 |
1999-11-30 |
Angiogenesis Technologies, Inc. |
Anti-angiogenic Compositions and methods for the treatment of arthritis
|
|
GB9317764D0
(en)
|
1993-08-26 |
1993-10-13 |
Pfizer Ltd |
Therapeutic compound
|
|
US5854234A
(en)
|
1993-10-21 |
1998-12-29 |
G. D. Searle & Co. |
Amidino dervatives useful as nitric oxide synthase inhibitors
|
|
DE4405712A1
(de)
|
1994-02-23 |
1995-08-24 |
Basf Ag |
Substituierte Naphthyridine und deren Verwendung
|
|
RU2114844C1
(ru)
|
1994-04-11 |
1998-07-10 |
Санкио Компани Лимитед |
Производные тиозолидиндиона или их фармацевтически приемлемые соли, фармацевтическая композиция на их основе и способ лечения или профилактики заболеваний
|
|
NZ293605A
(en)
|
1994-09-27 |
1998-07-28 |
Janssen Pharmaceutica Nv |
N-substituted piperidinyl bicyclic benzoate derivatives, 3-alkoxy-4-hydroxy-piperidine intermediates, and pharmaceutical compositions
|
|
US5656256A
(en)
|
1994-12-14 |
1997-08-12 |
The University Of North Carolina At Chapel Hill |
Methods of treating lung disease by an aerosol containing benzamil or phenamil
|
|
US5510379A
(en)
|
1994-12-19 |
1996-04-23 |
Warner-Lambert Company |
Sulfonate ACAT inhibitors
|
|
US6099562A
(en)
|
1996-06-13 |
2000-08-08 |
Schneider (Usa) Inc. |
Drug coating with topcoat
|
|
AU715658B2
(en)
|
1996-04-03 |
2000-02-10 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
CA2268051A1
(en)
|
1996-08-23 |
1998-02-26 |
Alanex Corporation |
Neuropeptide-y ligands
|
|
EP1003374A4
(en)
|
1996-12-30 |
2000-05-31 |
Merck & Co Inc |
INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
|
|
US5948814A
(en)
|
1997-02-20 |
1999-09-07 |
The Curators Of The University Of Missouri |
Genistein for the treatment of cystic fibrosis
|
|
WO1998047868A1
(en)
|
1997-04-18 |
1998-10-29 |
Smithkline Beecham Plc |
Heterocycle-containing urea derivatives as 5ht1a, 5ht1b and 5ht1d receptor antagonists
|
|
TR200000896T2
(tr)
|
1997-10-02 |
2000-09-21 |
Sankyo Company Limited |
Amidokarboksilik asit türevleri.
|
|
EP1054996B1
(en)
|
1998-02-17 |
2004-01-28 |
G.D. SEARLE & CO. |
Process for the enzymatic resolution of lactams
|
|
JP2002517483A
(ja)
|
1998-06-08 |
2002-06-18 |
シェーリング コーポレイション |
神経ペプチドy5レセプターアンタゴニスト
|
|
US6426331B1
(en)
|
1998-07-08 |
2002-07-30 |
Tularik Inc. |
Inhibitors of STAT function
|
|
AUPP609198A0
(en)
|
1998-09-22 |
1998-10-15 |
Curtin University Of Technology |
Use of non-peptidyl compounds for the treatment of insulin related ailments
|
|
IL142768A0
(en)
|
1998-12-18 |
2002-03-10 |
Du Pont Pharm Co |
N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
|
|
HRP20010604A2
(en)
|
1999-02-24 |
2002-08-31 |
Hoffmann La Roche |
3-phenylpyridine derivatives and their use as nk-1 receptor antagonists
|
|
SI1035115T1
(en)
|
1999-02-24 |
2005-02-28 |
F. Hoffmann-La Roche Ag |
4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists
|
|
CN1131212C
(zh)
|
1999-02-24 |
2003-12-17 |
弗·哈夫曼-拉罗切有限公司 |
苯基-和吡啶基衍生物
|
|
UA71971C2
(en)
|
1999-06-04 |
2005-01-17 |
Agoron Pharmaceuticals Inc |
Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
|
|
WO2000078733A1
(de)
|
1999-06-18 |
2000-12-28 |
Bayer Aktiengesellschaft |
Phenoxyfluorpyrimidine
|
|
UA74539C2
(en)
|
1999-12-08 |
2006-01-16 |
Pharmacia Corp |
Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants)
|
|
AU2010601A
(en)
|
1999-12-16 |
2001-07-03 |
Novartis Ag |
Organic compounds
|
|
NZ519984A
(en)
|
2000-01-07 |
2004-03-26 |
Transform Pharmaceuticals Inc |
High-throughput formation, identification, and analysis of diverse solid-forms
|
|
EP1253923A1
(en)
|
2000-01-28 |
2002-11-06 |
Biogen, Inc. |
Pharmaceutical compositions containing anti-beta 1 integrin compounds and uses
|
|
WO2001056989A2
(en)
|
2000-02-01 |
2001-08-09 |
Cor Therapeutics, Inc. |
Inhibitors of factor xa
|
|
WO2001081317A1
(en)
|
2000-04-26 |
2001-11-01 |
Gliatech, Inc. |
Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives
|
|
AU2000249828A1
(en)
|
2000-05-03 |
2001-11-12 |
Taisho Pharmaceutical Co. Ltd. |
Stat4 and stat6 binding dipeptide derivatives
|
|
WO2001092235A1
(en)
|
2000-06-01 |
2001-12-06 |
Bristol-Myers Squibb Pharma Company |
LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
|
|
TWI259180B
(en)
|
2000-08-08 |
2006-08-01 |
Hoffmann La Roche |
4-Phenyl-pyridine derivatives
|
|
JP2004509115A
(ja)
|
2000-09-15 |
2004-03-25 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
プロテインキナーゼインヒビターとして有用なピラゾール化合物
|
|
JP4272338B2
(ja)
|
2000-09-22 |
2009-06-03 |
バイエル アクチェンゲゼルシャフト |
ピリジン誘導体
|
|
WO2002028348A2
(en)
|
2000-10-04 |
2002-04-11 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treatment of cystic fibrosis
|
|
GB2367816A
(en)
|
2000-10-09 |
2002-04-17 |
Bayer Ag |
Urea- and thiourea-containing derivatives of beta-amino acids
|
|
DE60104014T2
(de)
|
2000-10-20 |
2005-08-11 |
Merck Patent Gmbh |
Chirale binaphtol-verbindungen
|
|
US6884782B2
(en)
|
2000-11-08 |
2005-04-26 |
Amgen Inc. |
STAT modulators
|
|
EP1339402B1
(en)
|
2000-12-01 |
2010-08-25 |
Eisai Inc. |
Azaphenanthridone derivatives and their use as parp inhibitors
|
|
GB0102687D0
(en)
|
2001-02-02 |
2001-03-21 |
Pharmacia & Upjohn Spa |
Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
|
|
US6531597B2
(en)
|
2001-02-13 |
2003-03-11 |
Hoffmann-La Roche Inc. |
Process for preparation of 2-phenyl acetic acid derivatives
|
|
JP2005520171A
(ja)
|
2001-04-10 |
2005-07-07 |
トランス テック ファーマ,インコーポレイテッド |
ドラッグディスカバリーに関する、プローブ、システム、および方法
|
|
AU2002250876B2
(en)
|
2001-04-23 |
2005-03-03 |
F. Hoffmann-La Roche Ag |
Use of NK-1 receptor antagonists against benign prostatic hyperplasia
|
|
BR0209920A
(pt)
|
2001-05-22 |
2004-03-30 |
Neurogen Corp |
Composto ou sal farmaceuticamente aceitável do mesmo, métodos de tratar ansiedade, depressão ou estresse e sìndrome do intestino irritável ou doença de crohn, de detectar receptores de crf1 em uma primeira amostra biológica, de demonstrar a presença ou ausência de receptores de crf1 em uma amostra biológica e de inibir a ligação de crf a um receptor de crf1, composição farmacêutica, e, embalagem
|
|
US20030083345A1
(en)
|
2001-07-10 |
2003-05-01 |
Torsten Hoffmann |
Method of treatment and/or prevention of brain, spinal or nerve injury
|
|
US6627646B2
(en)
|
2001-07-17 |
2003-09-30 |
Sepracor Inc. |
Norastemizole polymorphs
|
|
CA2448737C
(en)
|
2001-07-20 |
2010-06-01 |
Boehringer Ingelheim (Canada) Ltd. |
Viral polymerase inhibitors
|
|
AU2002322585A1
(en)
|
2001-07-20 |
2003-03-03 |
Adipogenix, Inc. |
Fat accumulation-modulating compounds
|
|
US7427623B2
(en)
|
2001-09-11 |
2008-09-23 |
Smithkline Beecham Corporation |
4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof
|
|
PA8557501A1
(es)
|
2001-11-12 |
2003-06-30 |
Pfizer Prod Inc |
Benzamida, heteroarilamida y amidas inversas
|
|
JP2003155285A
(ja)
|
2001-11-19 |
2003-05-27 |
Toray Ind Inc |
環状含窒素誘導体
|
|
JP2003221386A
(ja)
|
2001-11-26 |
2003-08-05 |
Takeda Chem Ind Ltd |
二環性誘導体、その製造法およびその用途
|
|
WO2003055482A1
(en)
|
2001-12-21 |
2003-07-10 |
Novo Nordisk A/S |
Amide derivatives as gk activators
|
|
TW200307539A
(en)
|
2002-02-01 |
2003-12-16 |
Bristol Myers Squibb Co |
Cycloalkyl inhibitors of potassium channel function
|
|
TW200304820A
(en)
|
2002-03-25 |
2003-10-16 |
Avanir Pharmaceuticals |
Use of benzimidazole analogs in the treatment of cell proliferation
|
|
TW200403058A
(en)
|
2002-04-19 |
2004-03-01 |
Bristol Myers Squibb Co |
Heterocyclo inhibitors of potassium channel function
|
|
FR2840807B1
(fr)
|
2002-06-12 |
2005-03-11 |
|
Composition cosmetique de soin et/ou de maquillage, structuree par des polymeres silicones et des organogelateurs, sous forme rigide
|
|
GB0221443D0
(en)
|
2002-09-16 |
2002-10-23 |
Glaxo Group Ltd |
Pyridine derivates
|
|
CA2501547A1
(en)
|
2002-10-15 |
2004-04-29 |
Rigel Pharmaceuticals, Inc. |
Substituted indoles and their use as hcv inhibitors
|
|
AU2003284188B2
(en)
|
2002-10-30 |
2010-02-25 |
Merck Sharp & Dohme Corp. |
Piperidinyl cyclopentyl aryl benzylamide modulators of chemokine receptor activity
|
|
BR0317183A
(pt)
|
2002-12-12 |
2005-11-01 |
Pharmacia Corp |
Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno
|
|
WO2004063179A1
(en)
|
2003-01-06 |
2004-07-29 |
Eli Lilly And Company |
Substituted arylcyclopropylacetamides as glucokinase activators
|
|
CN101723891A
(zh)
|
2003-02-10 |
2010-06-09 |
沃泰克斯药物股份有限公司 |
通过使n-芳基氨基甲酸酯与卤代杂芳基反应制备n-杂芳基-n-芳基胺的方法和类似方法
|
|
EP1601657A1
(en)
|
2003-03-12 |
2005-12-07 |
Vertex Pharmaceuticals Incorporated |
Pyrazole modulators of atp-binding cassette transporters
|
|
KR20060006953A
(ko)
|
2003-04-30 |
2006-01-20 |
디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 |
치환된 카르복실산
|
|
WO2004111014A1
(en)
|
2003-06-06 |
2004-12-23 |
Vertex Pharmaceuticals Incorporated |
Pyrimidine derivatives as modulators of atp-binding cassette transporters
|
|
GB0315111D0
(en)
|
2003-06-27 |
2003-07-30 |
Cancer Rec Tech Ltd |
Substituted 5-membered ring compounds and their use
|
|
WO2005002519A2
(en)
|
2003-06-27 |
2005-01-13 |
Henry M.Jackson Foundation For The Advancement Of Military Medicine, Inc. |
Amphiphilic pyridinium compounds, method of making and use thereof
|
|
JP2005053902A
(ja)
|
2003-07-18 |
2005-03-03 |
Nippon Nohyaku Co Ltd |
フェニルピリジン類、その中間体及びこれを有効成分とする除草剤
|
|
CA2537829A1
(en)
|
2003-09-05 |
2005-03-17 |
Neurogen Corporation |
Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands
|
|
MXPA06002567A
(es)
|
2003-09-06 |
2006-09-04 |
Vertex Pharma |
Moduladores de transportadores con casete de union de atp.
|
|
US7534894B2
(en)
|
2003-09-25 |
2009-05-19 |
Wyeth |
Biphenyloxy-acids
|
|
US20050070718A1
(en)
|
2003-09-30 |
2005-03-31 |
Abbott Gmbh & Co. Kg |
Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
|
|
WO2005035514A2
(en)
|
2003-10-08 |
2005-04-21 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters containing cycloalkyl or pyranyl groups
|
|
FR2861304B1
(fr)
|
2003-10-23 |
2008-07-18 |
Univ Grenoble 1 |
Modulateurs des canaux cftr
|
|
GB0325956D0
(en)
|
2003-11-06 |
2003-12-10 |
Addex Pharmaceuticals Sa |
Novel compounds
|
|
CN1925854A
(zh)
|
2003-11-14 |
2007-03-07 |
沃泰克斯药物股份有限公司 |
可用作atp-结合弹夹转运蛋白调控剂的噻唑和噁唑
|
|
WO2005049034A2
(en)
|
2003-11-19 |
2005-06-02 |
Glaxo Group Limited |
Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders
|
|
US7977322B2
(en)
|
2004-08-20 |
2011-07-12 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
ES2791303T3
(es)
|
2004-01-30 |
2020-11-03 |
Vertex Pharma |
Compuesto intermedio de moduladores de transportadores de casete de unión a ATP
|
|
CA2555409A1
(en)
|
2004-02-19 |
2005-09-01 |
Banyu Pharmaceutical Co., Ltd. |
Novel sulfone amide derivative
|
|
ES2241496B1
(es)
|
2004-04-15 |
2006-12-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de piridina.
|
|
EP1734820A4
(en)
|
2004-04-16 |
2008-01-23 |
Neurogen Corp |
Imidazopyrrazine, imidazopyridine, and imidazo-pyrimidine as CRF1 receptor ligands
|
|
US7585885B2
(en)
|
2004-04-22 |
2009-09-08 |
Eli Lilly And Company |
Pyrrolidine derivatives useful as BACE inhibitors
|
|
WO2005108391A1
(en)
|
2004-04-22 |
2005-11-17 |
Eli Lilly And Company |
Amides as bace inhibitors
|
|
AU2005249154B2
(en)
|
2004-06-01 |
2011-02-10 |
Luminex Molecular Diagnostics, Inc. |
Method of detecting cystic fibrosis associated mutations
|
|
US20140343098A1
(en)
|
2004-06-24 |
2014-11-20 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
|
US8354427B2
(en)
|
2004-06-24 |
2013-01-15 |
Vertex Pharmaceutical Incorporated |
Modulators of ATP-binding cassette transporters
|
|
ME02799B
(me)
|
2004-06-24 |
2018-01-20 |
Vertex Pharma |
Modulatori ATP-vezujućih kasetnih transportera
|
|
EP1781253A1
(en)
|
2004-07-01 |
2007-05-09 |
Warner-Lambert Company LLC |
Preparation of pharmaceutical compositions containing nanoparticles
|
|
CA2572292A1
(en)
|
2004-07-02 |
2006-02-09 |
Advancis Pharmaceutical Corporation |
Tablet for pulsed delivery
|
|
AU2005268030B2
(en)
|
2004-08-06 |
2009-02-19 |
Otsuka Pharmaceutical Co., Ltd. |
Aromatic compounds
|
|
CA2580838A1
(en)
|
2004-09-27 |
2006-04-06 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
CN101072758B
(zh)
|
2004-10-12 |
2013-07-31 |
阿斯利康(瑞典)有限公司 |
喹唑啉衍生物
|
|
WO2006051394A1
(en)
|
2004-11-15 |
2006-05-18 |
Pfizer Products Inc. |
Azabenzoxazoles for the treatment of cns disorders
|
|
RU2410372C2
(ru)
*
|
2004-12-15 |
2011-01-27 |
Домпе` Фа.Р.Ма С.П.А. |
Производные 2-арилпропионовой кислоты и фармацевтические композиции, их включающие
|
|
JP4790260B2
(ja)
|
2004-12-22 |
2011-10-12 |
出光興産株式会社 |
アントラセン誘導体を用いた有機エレクトロルミネッセンス素子
|
|
JP2008528580A
(ja)
|
2005-01-27 |
2008-07-31 |
アストラゼネカ・アクチエボラーグ |
P2x7受容体の阻害剤である新規二環式芳香族化合物
|
|
US7888374B2
(en)
|
2005-01-28 |
2011-02-15 |
Abbott Laboratories |
Inhibitors of c-jun N-terminal kinases
|
|
JPWO2006082952A1
(ja)
|
2005-02-01 |
2008-06-26 |
武田薬品工業株式会社 |
アミド化合物
|
|
WO2006099256A2
(en)
|
2005-03-11 |
2006-09-21 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
|
US7297700B2
(en)
|
2005-03-24 |
2007-11-20 |
Renovis, Inc. |
Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
|
|
EP1710246A1
(en)
|
2005-04-08 |
2006-10-11 |
Schering Aktiengesellschaft |
Sulfoximine-pyrimidine Macrocycles and the salts thereof, a process for making them, and their pharmaceutical use against cancer
|
|
AR053712A1
(es)
|
2005-04-18 |
2007-05-16 |
Neurogen Corp |
Heteroarilos sustituidos, antagonistas de cb1 (receptor 1 canabinoide)
|
|
BRPI0610850A2
(pt)
|
2005-04-19 |
2008-12-02 |
Bayer Pharmaceuticals Corp |
derivados de Ácido aril alquila, composiÇço farmacÊutica, medicamento, bem como uso dos referidos derivados
|
|
GB0510139D0
(en)
|
2005-05-18 |
2005-06-22 |
Addex Pharmaceuticals Sa |
Novel compounds B1
|
|
WO2006127588A2
(en)
|
2005-05-24 |
2006-11-30 |
Vertex Pharmaceuticals Incorporated |
Modulators of atp-binding cassette transporters
|
|
WO2006130403A1
(en)
|
2005-06-02 |
2006-12-07 |
Bayer Cropscience Ag |
Phenylalkyl substituted heteroaryl devivatives
|
|
WO2006136829A2
(en)
|
2005-06-21 |
2006-12-28 |
Astex Therapeutics Limited |
Pyrazole derivatives and their use as pka and pkb modulators
|
|
ZA200802172B
(en)
|
2005-08-11 |
2009-06-24 |
Vertex Pharma |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2007021982A2
(en)
|
2005-08-11 |
2007-02-22 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
PL1928886T3
(pl)
|
2005-09-09 |
2011-09-30 |
Nerre Therapeutics Ltd |
Pochodne pirydyny i ich zastosowanie w leczeniu zaburzeń psychotycznych
|
|
SI1928427T1
(sl)
|
2005-09-23 |
2010-03-31 |
Hoffmann La Roche |
Nove formulacije za doziranje
|
|
KR20080064971A
(ko)
|
2005-10-06 |
2008-07-10 |
버텍스 파마슈티칼스 인코포레이티드 |
Atp-결합 카세트 전달체의 조절자
|
|
PL1940821T3
(pl)
|
2005-10-19 |
2013-08-30 |
Gruenenthal Gmbh |
Nowe ligandy receptora waniloidowego i ich zastosowanie do wytwarzania leków
|
|
SI1945632T1
(sl)
*
|
2005-11-08 |
2014-03-31 |
Vertex Pharmaceuticals Incorporated |
Heterocikliäśni modulatorji za prenaĺ alce z atp-vezavno kaseto
|
|
US20120232059A1
(en)
|
2005-11-08 |
2012-09-13 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette Transporters
|
|
WO2007054480A1
(en)
|
2005-11-08 |
2007-05-18 |
N.V. Organon |
2-(benzimidazol-1-yl)-acetamide biaryl derivatives and their use as inhibitors of the trpv1 receptor
|
|
WO2007067506A2
(en)
|
2005-12-05 |
2007-06-14 |
Smithkline Beecham Corporation |
2-pyrimidinyl pyrazolopyridine erbb kinase inhibitors
|
|
EP1979367A2
(en)
|
2005-12-24 |
2008-10-15 |
Vertex Pharmaceuticals Incorporated |
Quinolin-4-one derivatives as modulators of abc transporters
|
|
AU2006331565A1
(en)
|
2005-12-27 |
2007-07-05 |
Vertex Pharmaceuticals Incorporated |
Compounds useful in CFTR assays and methods therewith
|
|
CN101395147B
(zh)
|
2005-12-28 |
2013-05-29 |
弗特克斯药品有限公司 |
作为atp-结合盒转运蛋白调节剂用于治疗囊性纤维化的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物及相关化合物
|
|
CA2635581C
(en)
|
2005-12-28 |
2017-02-28 |
Vertex Pharmaceuticals Incorporated |
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
US7671221B2
(en)
|
2005-12-28 |
2010-03-02 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
US7645789B2
(en)
|
2006-04-07 |
2010-01-12 |
Vertex Pharmaceuticals Incorporated |
Indole derivatives as CFTR modulators
|
|
US10022352B2
(en)
|
2006-04-07 |
2018-07-17 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
IN2014KN02423A
(cg-RX-API-DMAC7.html)
|
2006-04-07 |
2015-05-01 |
Vertex Pharma |
|
|
CN101478964B
(zh)
|
2006-05-12 |
2012-02-29 |
沃泰克斯药物股份有限公司 |
N-[2,4-双(1,1-二甲基乙基)-5-羟苯基]-1,4-二氢-4-氧代喹啉-3-羧酰胺的组合物
|
|
US8563573B2
(en)
|
2007-11-02 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Azaindole derivatives as CFTR modulators
|
|
JP5284268B2
(ja)
|
2006-11-03 |
2013-09-11 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Cftrモジュレーターとしてのアザインドール誘導体
|
|
US7754739B2
(en)
|
2007-05-09 |
2010-07-13 |
Vertex Pharmaceuticals Incorporated |
Modulators of CFTR
|
|
EP2097386A2
(en)
|
2006-11-27 |
2009-09-09 |
Novartis AG |
Substituted dihydroimidazoles and their use in the treatment of tumors
|
|
US20080260820A1
(en)
|
2007-04-19 |
2008-10-23 |
Gilles Borrelly |
Oral dosage formulations of protease-resistant polypeptides
|
|
EP2164840A2
(en)
*
|
2007-05-09 |
2010-03-24 |
Vertex Pharmaceuticals Incorporated |
Modulators of cftr
|
|
NZ581419A
(en)
|
2007-05-25 |
2012-05-25 |
Vertex Pharma |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2009023509A2
(en)
|
2007-08-09 |
2009-02-19 |
Vertex Pharmaceuticals Incorporated |
Therapeutic combinations useful in treating cftr related diseases
|
|
CN101827593B
(zh)
|
2007-08-24 |
2013-07-24 |
沃泰克斯药物股份有限公司 |
用于治疗(特别是)囊性纤维化的异噻唑并吡啶酮
|
|
DE102007042754A1
(de)
|
2007-09-07 |
2009-03-12 |
Bayer Healthcare Ag |
Substituierte 6-Phenylnikotinsäuren und ihre Verwendung
|
|
NZ600865A
(en)
|
2007-09-14 |
2014-01-31 |
Vertex Pharma |
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
CA2699382C
(en)
|
2007-09-14 |
2016-05-10 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
FR2921657A1
(fr)
|
2007-09-28 |
2009-04-03 |
Sanofi Aventis Sa |
Derives de nicotinamide, leur preparation et leur application en therapeutique
|
|
WO2009064959A1
(en)
|
2007-11-16 |
2009-05-22 |
Vertex Pharmaceuticals Incorporated |
Isoquinoline modulators of atp-binding cassette transporters
|
|
US20100036130A1
(en)
|
2007-12-07 |
2010-02-11 |
Vertex Pharmaceuticals Incorporated |
Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
|
|
PT2225230T
(pt)
|
2007-12-07 |
2016-12-07 |
Vertex Pharma |
Formas sólidas de ácido 3-(6(1-(2,2-difluorobenzo[d][1,3] dioxol-5-il) ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico
|
|
EA201070699A1
(ru)
|
2007-12-07 |
2011-02-28 |
Вертекс Фармасьютикалз Инкорпорейтед |
Композиции 3-(6-(1-2,2-дифторбензо[d][1,3]диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-2-ил)бензойной кислоты
|
|
PL2639223T3
(pl)
|
2007-12-07 |
2017-09-29 |
Vertex Pharmaceuticals Incorporated |
Sposób wytwarzania kwasów cykloalkilokarboksyamido-pirydyno-benzoesowych
|
|
ES2422741T3
(es)
|
2007-12-13 |
2013-09-13 |
Vertex Pharma |
Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
|
|
NZ620944A
(en)
|
2008-02-28 |
2015-02-27 |
Vertex Pharma |
Heteroaryl derivatives as cftr modulators
|
|
EP2271621B1
(en)
|
2008-03-31 |
2013-11-20 |
Vertex Pharmaceuticals Incorporated |
Pyridyl derivatives as cftr modulators
|
|
GB0813709D0
(en)
|
2008-07-26 |
2008-09-03 |
Univ Dundee |
Method and product
|
|
US20100256184A1
(en)
|
2008-08-13 |
2010-10-07 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition and administrations thereof
|
|
US20100074949A1
(en)
|
2008-08-13 |
2010-03-25 |
William Rowe |
Pharmaceutical composition and administration thereof
|
|
MX366161B
(es)
|
2008-08-13 |
2019-07-01 |
Vertex Pharmaceutical Incorporated |
Composicion farmaceutica y su administracion.
|
|
AU2009296271A1
(en)
|
2008-09-29 |
2010-04-01 |
Vertex Pharmaceuticals Incorporated |
Dosage units of 3-(6-(1-(2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
|
|
NZ592685A
(en)
|
2008-10-23 |
2013-04-26 |
Vertex Pharma |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
US8436014B2
(en)
|
2008-10-23 |
2013-05-07 |
Vertex Pharmaceutical Incorporated |
Solid forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluorormethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihyroquinoline-3-carboxamide
|
|
US20110257223A1
(en)
|
2008-10-23 |
2011-10-20 |
Vertex Pharmaceuticals Incorporated |
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
|
|
JP5645834B2
(ja)
|
2008-10-23 |
2014-12-24 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
嚢胞性線維症膜コンダクタンス制御因子の修飾因子
|
|
UA104876C2
(uk)
|
2008-11-06 |
2014-03-25 |
Вертекс Фармасьютікалз Інкорпорейтед |
Модулятори atф-зв'язувальних касетних транспортерів
|
|
AU2008363828B2
(en)
|
2008-11-06 |
2016-09-08 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-binding cassette transporters
|
|
JP5699090B2
(ja)
|
2008-12-30 |
2015-04-08 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
嚢胞性線維症膜コンダクタンス調節因子のモジュレーター
|
|
HRP20181261T1
(hr)
|
2009-03-20 |
2018-12-14 |
Vertex Pharmaceuticals Incorporated |
Modulatori regulatora transmembranske provodljivosti cistične fibroze
|
|
SI2408750T1
(sl)
|
2009-03-20 |
2015-11-30 |
Vertex Pharmaceuticals Incorporated |
Postopek za izdelavo modulatorjev cistično-fibroznega transmembranskega regulatorja prevodnosti
|
|
WO2010128359A1
(en)
|
2009-05-07 |
2010-11-11 |
Gea Pharma Systems Limited |
Tablet production module and method for continuous production of tablets
|
|
KR20120083416A
(ko)
|
2009-09-17 |
2012-07-25 |
버텍스 파마슈티칼스 인코포레이티드 |
아자비시클릭 화합물의 제조 방법
|
|
MX2012004792A
(es)
|
2009-10-22 |
2013-02-01 |
Vertex Pharma |
Composiciones para el tratamiento de fibrosis quistica y otras enfermedades cronicas.
|
|
BR112012009584A2
(pt)
|
2009-10-23 |
2019-09-24 |
Vertex Pharma |
formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-(trifluorometil)fenil)-4-oxo-5-(trifluorometil)-1,4-di-hidroquinolina-3-carboxamida
|
|
WO2011050215A1
(en)
|
2009-10-23 |
2011-04-28 |
Vertex Pharmaceuticals Incorporated |
Process for preparing modulators of cystic fibrosis transmembrane conductance regulator
|
|
WO2011116397A1
(en)
|
2010-03-19 |
2011-09-22 |
Vertex Pharmaceuticals Incorporated |
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
US8802868B2
(en)
|
2010-03-25 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
|
|
NZ602665A
(en)
|
2010-03-25 |
2014-10-31 |
Vertex Pharma |
Solid forms of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihyderoxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
|
|
HRP20211752T1
(hr)
|
2010-04-07 |
2022-02-18 |
Vertex Pharmaceuticals Incorporated |
Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena
|
|
EP2555754B1
(en)
|
2010-04-07 |
2016-04-06 |
Vertex Pharmaceuticals Incorporated |
Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
|
|
KR20130056244A
(ko)
|
2010-04-22 |
2013-05-29 |
버텍스 파마슈티칼스 인코포레이티드 |
시클로알킬카르복스아미도-인돌 화합물의 제조 방법
|
|
WO2011133956A1
(en)
|
2010-04-22 |
2011-10-27 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
AU2011242452A1
(en)
|
2010-04-22 |
2012-11-08 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
WO2011133953A1
(en)
|
2010-04-22 |
2011-10-27 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
AR081920A1
(es)
|
2010-05-20 |
2012-10-31 |
Vertex Pharma |
Procesos de produccion de moduladores del regulador de conductancia transmembrana de fibrosis quistica
|
|
AU2011255237A1
(en)
|
2010-05-20 |
2012-11-29 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions and administrations thereof
|
|
US8563593B2
(en)
|
2010-06-08 |
2013-10-22 |
Vertex Pharmaceuticals Incorporated |
Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
|
|
CA2808501A1
(en)
|
2010-08-23 |
2012-03-01 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration therof
|
|
AU2011293135A1
(en)
|
2010-08-27 |
2013-04-11 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical composition and administrations thereof
|
|
EP2452972B2
(de)
|
2010-11-10 |
2022-04-13 |
Continental Reifen Deutschland GmbH |
Nutzfahrzeugluftreifen
|
|
US8802700B2
(en)
|
2010-12-10 |
2014-08-12 |
Vertex Pharmaceuticals Incorporated |
Modulators of ATP-Binding Cassette transporters
|
|
WO2013067410A1
(en)
|
2011-11-02 |
2013-05-10 |
Vertex Pharmaceuticals Incorporated |
Use of (n- [2, 4 -bis (1, 1 -dimethylethyl) - 5 - hydroxyphenyl] - 1, 4 - dihydro - 4 - oxoquinoline - 3 - ca rboxamide) for treating cftr mediated diseases
|
|
US20140127901A1
(en)
|
2012-11-08 |
2014-05-08 |
Taiwan Semiconductor Manufacturing Company, Ltd. |
Low-k damage free integration scheme for copper interconnects
|
|
LT2776427T
(lt)
|
2011-11-08 |
2017-04-10 |
Vertex Pharmaceuticals Incorporated |
Atp surišančios kasetės transporterių moduliatoriai
|
|
UA114619C2
(uk)
|
2012-01-25 |
2017-07-10 |
Вертекс Фармасьютікалз Інкорпорейтед |
СКЛАД 3-(6-(1-(2,2-ДИФТОРОБЕНЗО[d][1,3]ДІОКСОЛ-5-ІЛ)ЦИКЛОПРОПАНКАРБОКСАМІДО)-3-МЕТИЛПІРИДИН-2-ІЛ)БЕНЗОЙНОЇ КИСЛОТИ
|
|
HK1203840A1
(en)
|
2012-02-27 |
2015-11-06 |
沃泰克斯药物股份有限公司 |
Pharmaceutical composition and administration thereof
|
|
US8674108B2
(en)
|
2012-04-20 |
2014-03-18 |
Vertex Pharmaceuticals Incorporated |
Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
EP2858645A1
(en)
|
2012-06-08 |
2015-04-15 |
Vertex Pharmaceuticals Incorporated |
Pharmaceuticl compositions for the treatment of cftr -mediated disorders
|
|
HK1209318A1
(en)
|
2012-07-16 |
2016-04-01 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
|
|
BR112015009913B1
(pt)
|
2012-11-02 |
2023-04-11 |
Vertex Pharmaceuticals Incorporated |
Comprimido compreendendo composto cristalino e dispersão sólida de composto substancialmente amorfo, seu processo de preparação, kit e método de preparação de um grânulo compreendendo composto cristalino e dispersão sólida de composto substancialmente amorfo
|
|
US20140221424A1
(en)
|
2013-01-30 |
2014-08-07 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions for use in the treatment of cystic fibrosis
|
|
ES2885181T3
(es)
|
2014-04-15 |
2021-12-13 |
Vertex Pharma |
Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
|
|
WO2016057572A1
(en)
|
2014-10-06 |
2016-04-14 |
Mark Thomas Miller |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
JP6746569B2
(ja)
|
2014-10-07 |
2020-08-26 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶
|
|
WO2016086136A1
(en)
|
2014-11-26 |
2016-06-02 |
Catabasis Pharmaceuticals, Inc. |
Fatty acid cysteamine conjugates of cftr modulators and their use in treating medical disorders
|
|
MA41031A
(fr)
|
2014-11-26 |
2017-10-03 |
Catabasis Pharmaceuticals Inc |
Conjugués cystéamine-acide gras et leur utilisation comme activateurs de l'autophagie
|
|
EP3226861A2
(en)
|
2014-12-05 |
2017-10-11 |
Centre National de la Recherche Scientifique (CNRS) |
Compounds for treating cystic fibrosis
|
|
JP6662885B2
(ja)
|
2015-01-26 |
2020-03-11 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
カルボン酸生物学的等価体としてのテトラゾロン
|
|
UY36680A
(es)
|
2015-05-19 |
2016-12-30 |
Glaxosmithkline Ip Dev Ltd |
Amidas heterocíclicas como inhibidores de quinasa
|