|
US3487890A
(en)
|
1967-04-14 |
1970-01-06 |
Boyles Bros Drilling Co |
Core drilling system
|
|
US3847890A
(en)
*
|
1971-11-01 |
1974-11-12 |
A Green |
Acidic monosaccharide-substituted proteins
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4356170A
(en)
|
1981-05-27 |
1982-10-26 |
Canadian Patents & Development Ltd. |
Immunogenic polysaccharide-protein conjugates
|
|
US4757006A
(en)
|
1983-10-28 |
1988-07-12 |
Genetics Institute, Inc. |
Human factor VIII:C gene and recombinant methods for production
|
|
US4970300A
(en)
|
1985-02-01 |
1990-11-13 |
New York University |
Modified factor VIII
|
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
US5250421A
(en)
|
1986-01-03 |
1993-10-05 |
Genetics Institute, Inc. |
Method for producing factor VIII:C-type proteins
|
|
US5198349A
(en)
|
1986-01-03 |
1993-03-30 |
Genetics Institute, Inc. |
Method for producing factor VIII:C and analogs
|
|
JPH0387173A
(ja)
|
1987-09-10 |
1991-04-11 |
Teijin Ltd |
ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
|
|
US5153265A
(en)
|
1988-01-20 |
1992-10-06 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
|
US4966999A
(en)
*
|
1988-06-07 |
1990-10-30 |
Cytogen Corporation |
Radiohalogenated compounds for site specific labeling
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
SE465222C5
(sv)
|
1989-12-15 |
1998-02-10 |
Pharmacia & Upjohn Ab |
Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
|
|
SE466754B
(sv)
|
1990-09-13 |
1992-03-30 |
Berol Nobel Ab |
Saett att kovalent binda biopolymerer till hydrofila ytor
|
|
US5492821A
(en)
|
1990-11-14 |
1996-02-20 |
Cargill, Inc. |
Stabilized polyacrylic saccharide protein conjugates
|
|
WO1992016555A1
(en)
|
1991-03-18 |
1992-10-01 |
Enzon, Inc. |
Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
|
|
GB9112212D0
(en)
*
|
1991-06-06 |
1991-07-24 |
Gregoriadis Gregory |
Pharmaceutical compositions
|
|
US5846951A
(en)
|
1991-06-06 |
1998-12-08 |
The School Of Pharmacy, University Of London |
Pharmaceutical compositions
|
|
US6037452A
(en)
|
1992-04-10 |
2000-03-14 |
Alpha Therapeutic Corporation |
Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
|
|
WO1994005332A2
(en)
|
1992-09-01 |
1994-03-17 |
Berlex Laboratories, Inc. |
Glycolation of glycosylated macromolecules
|
|
DE69329795T2
(de)
|
1992-10-02 |
2001-07-05 |
Genetics Institute, Inc. |
Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator
|
|
NZ250375A
(en)
|
1992-12-09 |
1995-07-26 |
Ortho Pharma Corp |
Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
FR2700268B1
(fr)
|
1993-01-13 |
1995-03-31 |
Lvmh Rech |
Composition cosmétique ou pharmaceutique, notamment dermatologique, contenant un extrait de Vismia.
|
|
AU6029594A
(en)
|
1993-01-15 |
1994-08-15 |
Enzon, Inc. |
Factor viii - polymeric conjugates
|
|
WO1994028024A1
(en)
|
1993-06-01 |
1994-12-08 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
|
US5621039A
(en)
|
1993-06-08 |
1997-04-15 |
Hallahan; Terrence W. |
Factor IX- polymeric conjugates
|
|
SE504074C2
(sv)
|
1993-07-05 |
1996-11-04 |
Pharmacia Ab |
Proteinberedning för subkutan, intramuskulär eller intradermal administrering
|
|
WO1996041813A2
(en)
|
1994-11-09 |
1996-12-27 |
Offord Robin E |
Functionalized polymers for site-specific attachment
|
|
AU6255096A
(en)
|
1995-06-07 |
1996-12-30 |
Mount Sinai School Of Medicine Of The City University Of New York, The |
Pegylated modified proteins
|
|
SE9503380D0
(sv)
|
1995-09-29 |
1995-09-29 |
Pharmacia Ab |
Protein derivatives
|
|
US5763401A
(en)
*
|
1996-07-12 |
1998-06-09 |
Bayer Corporation |
Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
|
|
DE69800640T2
(de)
|
1997-01-29 |
2001-07-05 |
Polymasc Pharmaceuticals Plc, London |
Pegylationsverfahren
|
|
EP0981548A4
(en)
|
1997-04-30 |
2005-11-23 |
Enzon Inc |
GLYCOSYLATABLE SINGLE CHAIN ANTIGEN-BINDING PROTEINS, MANUFACTURE AND USE THEREOF
|
|
US6183738B1
(en)
|
1997-05-12 |
2001-02-06 |
Phoenix Pharamacologics, Inc. |
Modified arginine deiminase
|
|
WO2001082943A2
(en)
|
2000-05-03 |
2001-11-08 |
Novo Nordisk A/S |
Subcutaneous administration of coagulation factor vii
|
|
ES2252876T5
(es)
|
1997-12-03 |
2014-04-03 |
Roche Diagnostics Gmbh |
Proceso para preparar polipéptidos con glicolización adecuada
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
JP4545928B2
(ja)
|
1998-04-27 |
2010-09-15 |
ジリップ・ファーマ・ビー．ブイ． |
第ｖｉｉｉ因子及び中性リポソームを含有する薬学的組成物
|
|
US6552167B1
(en)
|
1998-08-28 |
2003-04-22 |
Gryphon Therapeutics, Inc. |
Polyamide chains of precise length
|
|
DK1656952T3
(da)
|
1998-10-16 |
2014-01-20 |
Biogen Idec Inc |
Polyalkylenglycolkonjugater af interferon beta-1A og anvendelser deraf
|
|
DE19852729A1
(de)
|
1998-11-16 |
2000-05-18 |
Werner Reutter |
Rekombinante Glycoproteine, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und ihre Verwendung
|
|
EP2921180B1
(en)
|
1999-02-22 |
2019-08-14 |
University of Connecticut |
Albumin-free factor VIII formulations
|
|
US6531122B1
(en)
|
1999-08-27 |
2003-03-11 |
Maxygen Aps |
Interferon-β variants and conjugates
|
|
CN1309423C
(zh)
|
1999-11-12 |
2007-04-11 |
马克西根控股公司 |
干扰素γ偶联物
|
|
DE60138364D1
(de)
|
2000-02-11 |
2009-05-28 |
Bayer Healthcare Llc |
Gerinnungsfaktor vii oder viia konjugate
|
|
US6586398B1
(en)
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
DE60143292D1
(de)
|
2000-05-03 |
2010-12-02 |
Novo Nordisk Healthcare Ag |
Varianten des menschlichen Koagulationsfaktors VII
|
|
CN1434726A
(zh)
*
|
2000-06-08 |
2003-08-06 |
拉卓拉药物公司 |
包含高分子量聚环氧乙烷的多价平台分子
|
|
US6423826B1
(en)
|
2000-06-30 |
2002-07-23 |
Regents Of The University Of Minnesota |
High molecular weight derivatives of vitamin K-dependent polypeptides
|
|
US7118737B2
(en)
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
AU8755001A
(en)
|
2000-09-13 |
2002-03-26 |
Novo Nordisk As |
Human coagulation factor vii variants
|
|
EP1325127B1
(en)
*
|
2000-10-02 |
2009-03-11 |
Novo Nordisk Health Care AG |
Method for the production of vitamin k-dependent proteins
|
|
US20040082765A1
(en)
|
2000-10-16 |
2004-04-29 |
Teruo Nakamura |
Peg-modified erythropoietin
|
|
MXPA03008590A
(es)
|
2001-03-22 |
2003-12-08 |
Novo Nordisk Healthcare Ag |
Derivados del factor vii de coagulacion.
|
|
US6913915B2
(en)
|
2001-08-02 |
2005-07-05 |
Phoenix Pharmacologics, Inc. |
PEG-modified uricase
|
|
US7795210B2
(en)
*
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
|
US7214660B2
(en)
*
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
EP2042196B1
(en)
*
|
2001-10-10 |
2016-07-13 |
ratiopharm GmbH |
Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF)
|
|
US8008252B2
(en)
*
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
AU2002352524B2
(en)
|
2001-11-07 |
2007-10-04 |
Nektar Therapeutics |
Branched polymers and their conjugates
|
|
JP2005510229A
(ja)
|
2001-11-28 |
2005-04-21 |
ネオーズ テクノロジーズ， インコーポレイテッド |
アミダーゼを用いる糖タンパク質のリモデリング
|
|
JP2005535280A
(ja)
|
2001-11-28 |
2005-11-24 |
ネオーズ テクノロジーズ， インコーポレイテッド |
エンドグリカナーゼを用いる糖タンパク質のリモデリング
|
|
RU2362807C2
(ru)
*
|
2002-06-21 |
2009-07-27 |
Ново Нордиск Хелт Кэр Аг |
Конъюгат полипептида фактора vii, способ его получения, его применение и содержащая его фармацевтическая композиция
|
|
MXPA04012496A
(es)
|
2002-06-21 |
2005-09-12 |
Novo Nordisk Healthcare Ag |
Glicoformos del factor vii pegilados.
|
|
US7122189B2
(en)
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7087229B2
(en)
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
BR0314106A
(pt)
*
|
2002-09-11 |
2005-07-19 |
Fresenius Kabi De Gmbh |
Polipeptìdeos hasilados, especialmente eritropoietina hasilada
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
EP1578841B2
(en)
*
|
2002-12-31 |
2016-10-12 |
Nektar Therapeutics AL, Corporation |
Maleamic acid polymer derivatives and their bioconjugates
|
|
WO2004060965A2
(en)
|
2002-12-31 |
2004-07-22 |
Nektar Therapeutics Al, Corporation |
Hydrolytically stable maleimide-terminated polymers
|
|
WO2004075923A2
(en)
*
|
2003-02-26 |
2004-09-10 |
Nektar Therapeutics Al, Corporation |
Polymer-factor viii moiety conjugates
|
|
WO2004091499A2
(en)
*
|
2003-04-09 |
2004-10-28 |
Neose Technologies, Inc. |
Intracellular formation of peptide conjugates
|
|
EP1654004A2
(en)
|
2003-08-08 |
2006-05-10 |
Novo Nordisk A/S |
Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides
|
|
EP1653991A2
(en)
|
2003-08-08 |
2006-05-10 |
Fresenius Kabi Deutschland GmbH |
Conjugates of a polymer and a protein linked by an oxime linking group
|
|
WO2005016974A1
(en)
|
2003-08-12 |
2005-02-24 |
Lipoxen Technologies Limited |
Sialic acid derivatives for protein derivatisation and conjugation
|
|
JP2007501888A
(ja)
|
2003-08-12 |
2007-02-01 |
リポクセン テクノロジーズ リミテッド |
ポリシアル酸誘導体
|
|
JP2007509843A
(ja)
*
|
2003-10-07 |
2007-04-19 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
第ＶＩＩ／ＶＩＩａ因子活性を有するハイブリッド分子
|
|
AU2004296860B2
(en)
|
2003-12-03 |
2010-04-22 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
US7338933B2
(en)
|
2004-01-08 |
2008-03-04 |
Neose Technologies, Inc. |
O-linked glycosylation of peptides
|
|
KR100651220B1
(ko)
|
2004-06-29 |
2006-11-29 |
씨제이 주식회사 |
Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법
|
|
JP2008506446A
(ja)
|
2004-07-14 |
2008-03-06 |
マリー アレル， |
授乳瓶
|
|
WO2006020372A2
(en)
|
2004-07-23 |
2006-02-23 |
Neose Technologies, Inc. |
Enzymatic modification of glycopeptides
|
|
JP2008507990A
(ja)
|
2004-08-02 |
2008-03-21 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
Ｆｖｉｉの抱合体
|
|
WO2006016168A2
(en)
*
|
2004-08-12 |
2006-02-16 |
Lipoxen Technologies Limited |
Sialic acid derivatives
|
|
KR101468345B1
(ko)
|
2004-11-12 |
2014-12-03 |
바이엘 헬스케어 엘엘씨 |
Ｆｖｉｉｉ의 부위 지향 변형
|
|
CA2591852A1
(en)
*
|
2004-12-27 |
2006-07-06 |
Baxter International Inc. |
Polymer-von willebrand factor-conjugates
|
|
JP2008526864A
(ja)
|
2005-01-06 |
2008-07-24 |
ネオス テクノロジーズ インコーポレイテッド |
糖断片を用いる糖結合
|
|
CN101160326B
(zh)
*
|
2005-02-23 |
2013-04-10 |
利普生技术有限公司 |
用于蛋白质衍生和缀合的活化的唾液酸衍生物
|
|
AU2006222187A1
(en)
*
|
2005-03-11 |
2006-09-14 |
Fresenius Kabi Deutschland Gmbh |
Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch
|
|
EP1891231A4
(en)
|
2005-05-25 |
2011-06-22 |
Novo Nordisk As |
GLYCOPEGYLATED FACTOR IX
|
|
EP1893632B1
(en)
|
2005-06-17 |
2015-08-12 |
Novo Nordisk Health Care AG |
Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
|
|
WO2007022784A2
(en)
|
2005-08-26 |
2007-03-01 |
Maxygen Holdings Ltd. |
Liquid factor vii composition
|
|
BRPI0620316A2
(pt)
|
2005-12-21 |
2011-11-08 |
Wyeth Corp |
formulações de proteìnas com viscosidades reduzida e seus usos
|
|
US7982010B2
(en)
*
|
2006-03-31 |
2011-07-19 |
Baxter International Inc. |
Factor VIII polymer conjugates
|
|
US7985839B2
(en)
*
|
2006-03-31 |
2011-07-26 |
Baxter International Inc. |
Factor VIII polymer conjugates
|
|
US7645860B2
(en)
*
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
|
CA2647314A1
(en)
|
2006-03-31 |
2007-11-08 |
Baxter International Inc. |
Pegylated factor viii
|
|
EP2089052A4
(en)
|
2006-05-24 |
2011-02-16 |
Peg Biosciences |
POLYETHYLENE GLYCOL-BASED LINK COMPOUNDS AND BIOLOGICALLY ACTIVE CONJUGATES BASED ON SAID COMPOUNDS
|
|
JP2007319283A
(ja)
*
|
2006-05-31 |
2007-12-13 |
Nippon Sherwood Medical Industries Ltd |
医療用バッグ
|
|
US7939632B2
(en)
*
|
2006-06-14 |
2011-05-10 |
Csl Behring Gmbh |
Proteolytically cleavable fusion proteins with high molar specific activity
|
|
WO2008035373A2
(en)
|
2006-07-13 |
2008-03-27 |
Serum Institute Of India Ltd |
Highly pure polysialic acid and process for preperation thereof
|
|
WO2008012528A1
(en)
|
2006-07-25 |
2008-01-31 |
Lipoxen Technologies Limited |
N-terminal polysialylation
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
CA2670618C
(en)
|
2006-12-15 |
2016-10-04 |
Baxter International Inc. |
Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life
|
|
EP2099475B1
(en)
|
2007-01-03 |
2016-08-24 |
Novo Nordisk Health Care AG |
Subcutaneous administration of coagulation factor viia-related polypeptides
|
|
WO2008119815A1
(en)
|
2007-04-02 |
2008-10-09 |
Novo Nordisk A/S |
Subcutaneous administration of coagulation factor ix
|
|
JP5622569B2
(ja)
|
2007-06-26 |
2014-11-12 |
バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ |
加水分解性ポリマーｆｍｏｃ−リンカー
|
|
EP2173759A4
(en)
|
2007-07-03 |
2014-01-29 |
Childrens Hosp & Res Ct Oak |
OLIGOSIAL INSERTS, PROCESS FOR THEIR PREPARATION AND ITS IMMUNOLOGICAL USE
|
|
KR20100090684A
(ko)
|
2007-10-09 |
2010-08-16 |
폴리테릭스 리미티드 |
신규한 접합 단백질 및 펩티드
|
|
CA2711503A1
(en)
|
2008-01-08 |
2009-07-16 |
Biogenerix Ag |
Glycoconjugation of polypeptides using oligosaccharyltransferases
|
|
KR101582841B1
(ko)
|
2008-02-27 |
2016-01-11 |
노보 노르디스크 에이/에스 |
콘쥬게이트된 인자 ｖｉｉｉ 분자
|
|
WO2009130602A2
(en)
|
2008-04-24 |
2009-10-29 |
Celtic Pharma Peg Ltd. |
Factor ix conjugates with extended half-lives
|
|
CN102065899A
(zh)
|
2008-05-23 |
2011-05-18 |
诺沃-诺迪斯克保健股份有限公司 |
含有高浓度的芳香族防腐剂的peg-官能化的丝氨酸蛋白酶的制剂
|
|
WO2009141433A1
(en)
|
2008-05-23 |
2009-11-26 |
Novo Nordisk Health Care Ag |
Low viscosity compositions comprising a pegylated gla-domain containing protein
|
|
CA2726942A1
(en)
|
2008-06-04 |
2009-12-10 |
Bayer Healthcare Llc |
Fviii muteins for treatment of von willebrand disease
|
|
EP2374481B1
(en)
|
2008-07-21 |
2015-11-04 |
Polytherics Limited |
Novel reagents and method for conjugating biological molecules
|
|
CA2740793A1
(en)
|
2008-11-03 |
2010-06-03 |
Haiyan Jiang |
Method for the treatment of hemophilia
|
|
WO2010083536A1
(en)
|
2009-01-19 |
2010-07-22 |
Bayer Healthcare Llc |
Protein conjugate having an endopeptidase-cleavable bioprotective moiety
|
|
EP2398822B1
(en)
|
2009-02-19 |
2013-01-02 |
Novo Nordisk A/S |
Modification of factor viii
|
|
US9005598B2
(en)
|
2009-03-04 |
2015-04-14 |
Polytherics Limited |
Conjugated proteins and peptides
|
|
US20100330033A1
(en)
|
2009-04-16 |
2010-12-30 |
Nian Wu |
Protein-carrier conjugates
|
|
GB0908393D0
(en)
|
2009-05-15 |
2009-06-24 |
Almac Sciences Scotland Ltd |
Labelling method
|
|
CN102497884A
(zh)
|
2009-07-27 |
2012-06-13 |
巴克斯特国际公司 |
凝血蛋白缀合物
|
|
KR101912335B1
(ko)
|
2009-07-27 |
2018-10-26 |
리폭센 테크놀로지즈 리미티드 |
비혈액 응고 단백질의 글리코폴리시알화
|
|
EP2461821A4
(en)
|
2009-07-31 |
2013-07-03 |
Bayer Healthcare Llc |
MODIFIED POLYPEPTIDES OF FACTOR IX AND USES THEREOF
|
|
DE102009028526A1
(de)
|
2009-08-13 |
2011-02-24 |
Leibniz-Institut Für Polymerforschung Dresden E.V. |
Verfahren zur Modifikation und Funktionalisierung von Sacchariden
|
|
EP2480578A4
(en)
|
2009-09-25 |
2013-04-17 |
Vybion Inc |
MODIFICATION OF POLYPEPTIDE
|
|
WO2011064247A1
(en)
|
2009-11-24 |
2011-06-03 |
Novo Nordisk Health Care Ag |
Method of purifying pegylated proteins
|
|
US20130040888A1
(en)
|
2010-02-16 |
2013-02-14 |
Novo Nordisk A/S |
Factor VIII Molecules With Reduced VWF Binding
|
|
GB201007357D0
(en)
|
2010-04-30 |
2010-06-16 |
Leverton Licence Holdings Ltd |
Conjugated factor VIII
|
|
GB201007356D0
(en)
|
2010-04-30 |
2010-06-16 |
Leverton Licence Holdings Ltd |
Conjugated factor VIIa
|
|
WO2012068134A1
(en)
|
2010-11-15 |
2012-05-24 |
Biogen Idec Inc. |
Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
|
|
CN103796670A
(zh)
|
2011-07-08 |
2014-05-14 |
比奥根艾迪克依蒙菲利亚公司 |
因子viii嵌合和杂合多肽及其使用方法
|