JP2010508852A - 電気活性バイオポリマー光学デバイスおよび電気活性バイオポリマー電気光学デバイスならびにその製造方法 - Google Patents
電気活性バイオポリマー光学デバイスおよび電気活性バイオポリマー電気光学デバイスならびにその製造方法 Download PDFInfo
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Abstract
Description
本出願は、米国仮特許出願第60/856,297号明細書(出願日:2006年11月3日、発明の名称:「Biopolymer Devices and Methods for Manufacturing the Same」)の優先権の恩典を主張する。
本発明は、the Air Force Office of Scientific Researchにより交付番号FA95500410363号として与えられた政府支援のもとになされた。本発明に関して政府は一定の権利を保有している。
本発明は、電気活性バイオポリマー光学デバイスおよび電気活性バイオポリマー電気光学デバイスならびにそのようなデバイスを製造するための方法に関する。本発明はさらに、バイオポリマー光学デバイスおよびバイオポリマー電気光学デバイスに対する電子工学および電気的集積化に関する。
光学の分野は、十分に確立されている。光学のいくつかのサブフィールドとしては、回折光学、微小光学、フォトニクス、および導波光学などが挙げられる。研究用途および商業用途のための光学のこれらおよびその他のサブフィールドにおいて、各種の光学デバイスが作製されてきた。例えば、一般的な光学デバイスとしては、回折格子、フォトニック結晶、光流体デバイス、導波路、レンズ、マイクロレンズアレイ、パターン発生器、ビームリシェーパーなどが挙げられる。
上述のような優れた機能特性および加工性を考慮して、本発明によるバイオポリマー光学デバイスは、絹のようなバイオポリマーを使用して作製したものとして記述する。これに関しては、使用された絹はカイコ絹であった。しかしながら、各種の絹、例えばクモの糸、トランスジェニックの絹、および遺伝子改変の絹、それらの変種および組み合わせなどが存在し、それらを代用品として使用して、本発明によるバイオポリマー光学デバイスを製造してもよい。
絹の膜中における抗体の安定性
材料
抗IL−8モノクローナル抗体(IgG1)は、eBioscience,Inc.から購入した。ヒトポリクローナル抗体IgGおよびヒトIgG ELISA Quantitation Kitは、Bethyl Laboratories Inc.から購入した。研究において使用したその他の全ての化学薬剤は、Sigma−Aldrich(St.Louis,MO)から購入した。
167mLの6%絹溶液と混合した10mLのIgG(1mg/mL)で、絹の膜中IgG濃縮物(1mg/g絹)を作製する。100μLの混合IgG溶液を、96ウェルプレートのそれぞれのウェルに添加し、カバーを開けて、換気フードの中に一夜置いた。その乾燥させた膜は、メタノールを用いて処理するか、未処理のままとした。メタノール処理の場合には、ウェルを90%メタノール溶液中に5分間浸漬させ、換気フードの中で乾燥させた。次いで、乾燥させた96ウェルプレートの全部を、4℃、室温、および37℃で保存した。
83mLの6%絹溶液と混合した0.5mLのIgG1(1mg/mL)で、絹の膜中IgG1濃縮物(0.1mg/g絹)を作製する。50μLの混合IgG1溶液を、96ウェルプレートのウェルに添加し、カバーを開けて、換気フードの中に一夜置いた。その乾燥させた膜は、メタノールを用いて処理するか、未処理のままとした。メタノール処理の場合には、ウェルを90%メタノール溶液中に5分間浸漬させ、換気フードの中で乾燥させた。次いで、乾燥させた96ウェルプレートの全部を、4℃、室温、および37℃で保存した。
統計解析のため、同一の条件下で調製した5個のウェルについて測定した。純粋な絹(抗体なし)を対照として使用した。
ポリスチレン(96ウェル)マイクロタイタープレートを、抗原コーティング緩衝液(重炭酸塩緩衝液、50mM、pH9.6)中で調製した10μg/mLの濃度の100μLの抗原抗ヒトIgG−アフィニティを用いてコーティングし、次いで室温で保存して一夜インキュベートした。次いでTBS−T緩衝液を用いて、それらのウェルを3回洗浄した。1%のBSA(TBS中)を各ウェル200μLずつ用いて非占有部位(unoccupied site)をブロックし、次いで室温で30分間インキュベートした。次いでTBS−Tを用いて、それらのウェルを3回洗浄した。次いで、段階希釈の血清100μLを用いて、試験ウェルおよび対照ウェルを希釈した。それぞれの希釈は、TBS緩衝液中で実施した。それぞれの希釈に対応する、段階希釈のブランクもまた存在させた。次いでそのプレートを、室温で1時間インキュベートした。プレートを、TBS−T緩衝液を用いて再び洗浄した(5回)。結合された抗体について、抗ヒトIgG−HRP(1:100,000)の適切な結合体を用いて試験し、その100μLをそれぞれのウェルの中にコーティングし、室温で1時間維持した。TBS−Tを用いてプレートを(5回)洗浄した後に、それぞれのウェルに100μLのTMBを添加し、室温で5〜20分間インキュベートした。それぞれのウェルの450nmでの吸光度を、VersaMaxマイクロプレートリーダー(Molecular devices、Sunnyvale,CA)を用いて測定した。
図A:2種の異なったフォーマットで調製し、3種の異なった温度で保存した絹の膜中での初期活性に対する抗体IgG1活性
図B:2種の異なったフォーマットで調製し、3種の異なった温度で保存した絹の膜中での初期活性に対する抗体IgG活性
Claims (26)
- ポリマーを提供する工程;
基材を提供する工程;
前記基材の上に前記ポリマーをキャストする工程;
有機化合物を酵素的に重合させて、前記ポリマーと前記基材との間に導電性ポリマーを生成させる工程
を含む、導電性ポリマーの製造方法。 - 導電性ポリマーがバイオポリマーである、請求項1に記載の導電性ポリマーの製造方法。
- バイオポリマーが絹である、請求項2に記載の導電性ポリマーの製造方法。
- ポリマーがマトリックス溶液であり、かつ重合が前記マトリックス溶液から実施される、請求項1に記載の導電性ポリマーの製造方法。
- ポリマーが固形物であり、かつ重合が前記固形物から実施される、請求項1に記載の導電性ポリマーの製造方法。
- 酵素的に重合させる工程が、ペルオキシダーゼ酵素反応を用いて有機化合物を触媒することを含む、請求項1に記載の導電性ポリマーの製造方法。
- 有機化合物がチロシンである、請求項6に記載の導電性ポリマーの製造方法。
- チロシン−酵素重合によって形成された導電層である界面を、ポリマーと基材との間に形成させる工程をさらに含む、請求項7に記載の導電性ポリマーの製造方法。
- 界面が、炭素−炭素結合主鎖を含む、請求項8に記載の導電性ポリマーの製造方法。
- バイオポリマーが、キトサン、コラーゲン、ゼラチン、アガロース、キチン、ポリヒドロキシアルカノエート、プラン(pullan)、デンプン(アミロース アミロペクチン)、セルロース、ヒアルロン酸、および関連するバイオポリマーからなる群、またはそれらの組み合わせより選択される、請求項1に記載の導電性バイオポリマーの製造方法。
- ポリマーがポリジメチルシロキサン(PDMS)である、請求項1に記載のバイオポリマー光導波路の製造方法。
- 基材が、光学デバイスのためのテンプレートである、請求項1に記載の方法。
- 基材が、電気光学コレクター、ソーラーコレクター、光学的読取りを有する機械式アクチュエーター、レンズ、マイクロレンズアレイ、光学格子、パターン発生器、およびビームリシェーパーのうちの少なくとも一つのためのテンプレートである、請求項12に記載の方法。
- バルクのタンパク質;
基材;
有機化合物;および
前記有機化合物を重合させて、ポリマーと基材との間に導電性ポリマーを生成させる酵素
を含む、導電性ポリマー。 - 導電性ポリマーがバイオポリマーである、請求項14に記載の導電性ポリマー。
- バイオポリマーが絹である、請求項15に記載の導電性ポリマー。
- ポリマーがマトリックス溶液であり、かつ重合が前記マトリックス溶液から実施される、請求項14に記載の導電性ポリマー。
- ポリマーが固形物であり、かつ重合が固形物から実施される、請求項14に記載の導電性ポリマー。
- 酵素的に重合させる工程が、ペルオキシダーゼ酵素反応を用いて有機化合物を触媒することを含む、請求項14に記載の導電性ポリマー。
- 有機化合物がチロシンである、請求項19に記載の導電性ポリマー。
- チロシン−酵素重合によって形成された導電層である界面を、ポリマーと基材との間にさらに含む、請求項20に記載の導電性ポリマー。
- 界面が、炭素−炭素結合主鎖を含む、請求項21に記載の導電性ポリマー。
- バイオポリマーが、キトサン、コラーゲン、ゼラチン、アガロース、キチン、ポリヒドロキシアルカノエート、プラン、デンプン(アミロース アミロペクチン)、セルロース、ヒアルロン酸、および関連するバイオポリマーからなる群、またはそれらの組み合わせより選択される、請求項15に記載の導電性ポリマー。
- ポリマーがポリジメチルシロキサン(PDMS)である、請求項14に記載の導電性ポリマー。
- 基材が、光学デバイスのためのテンプレートである、請求項14に記載の導電性ポリマー。
- 基材が、電気光学コレクター、ソーラーコレクター、光学的読取りを有する機械式アクチュエーター、レンズ、マイクロレンズアレイ、光学格子、パターン発生器、およびビームリシェーパーのうちの少なくとも一つのためのテンプレートである、請求項25に記載の導電性ポリマー。
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JP2009536421A Pending JP2010508852A (ja) | 2006-11-03 | 2007-11-05 | 電気活性バイオポリマー光学デバイスおよび電気活性バイオポリマー電気光学デバイスならびにその製造方法 |
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WO2008127401A3 (en) | 2009-03-05 |
US20100063404A1 (en) | 2010-03-11 |
JP2010509644A (ja) | 2010-03-25 |
EP2612751A2 (en) | 2013-07-10 |
US10040834B2 (en) | 2018-08-07 |
EP2107964B1 (en) | 2016-08-31 |
EP2107964A2 (en) | 2009-10-14 |
CA2704304A1 (en) | 2008-10-23 |
US10280204B2 (en) | 2019-05-07 |
WO2008127401A2 (en) | 2008-10-23 |
US20100065784A1 (en) | 2010-03-18 |
CA2704309A1 (en) | 2008-11-20 |
US20140039159A1 (en) | 2014-02-06 |
EP2109634A2 (en) | 2009-10-21 |
CA2704309C (en) | 2017-02-28 |
US8195021B2 (en) | 2012-06-05 |
WO2008127403A3 (en) | 2008-12-24 |
US8574461B2 (en) | 2013-11-05 |
WO2008140562A2 (en) | 2008-11-20 |
US20100096763A1 (en) | 2010-04-22 |
EP2612751A3 (en) | 2013-11-13 |
CA2704304C (en) | 2015-01-13 |
US20140349380A1 (en) | 2014-11-27 |
WO2008140562A3 (en) | 2009-03-05 |
US20160376331A1 (en) | 2016-12-29 |
WO2008127403A2 (en) | 2008-10-23 |
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