JP2009542831A - ポリウレタンエラストマー - Google Patents
ポリウレタンエラストマー Download PDFInfo
- Publication number
- JP2009542831A JP2009542831A JP2009517399A JP2009517399A JP2009542831A JP 2009542831 A JP2009542831 A JP 2009542831A JP 2009517399 A JP2009517399 A JP 2009517399A JP 2009517399 A JP2009517399 A JP 2009517399A JP 2009542831 A JP2009542831 A JP 2009542831A
- Authority
- JP
- Japan
- Prior art keywords
- peg
- ppg
- linear polymer
- polymer
- polymer according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4804—Two or more polyethers of different physical or chemical nature
- C08G18/4808—Mixtures of two or more polyetherdiols
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
- C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
- C08G18/6666—Compounds of group C08G18/48 or C08G18/52
- C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
- C08G18/6674—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
- C08G18/75—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
- C08G18/758—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing two or more cycloaliphatic rings
Abstract
Description
ここで、PEGはポリエチレングリコールを意味し、PPGはポリプロピレングリコールを意味する。
(a)ポリエチレングリコールまたはポリプロピレングリコール、
(b)PEG−PPG−PEG共重合体とまたはPPG−PEG−PPGブロック共重合体と
(c)二官能性化合物、
(d)二官能性イソシアネート
を共に反応させることにより得られる親水性で熱可塑性のポリウレタンエラストマーポリマーを提供する。
種々のポリエチレングリコール、ポリプロピレングリコール、PEG−PPG−PEG、PPG−PEG−PPG、ジオール、ジイソシアネートを理論混合比の範囲で用い、親水性線状ポリウレタンエラストマーポリマーに対する効果を検証した。PEG400、PEG900、PEG1000、及びPEG2000は、それぞれ分子量400、900、1000、及び2000g/molのポリエチレングリコールである。PPG1000及びPPG2000は、それぞれ分子量1000及び2000g/molのポリプロピレングリコールである。PEG−PPG−PEG1100及びPEG−PPG−PEG4400は、それぞれ分子量1100及び4400g/molのブロック共重合体である。PPG−PEG−PPG2000は、分子量2000g/molのブロック共重合体である。DDは1,10−デカンジオール、DDDは1,12−ドデカンジオール、DMDIはジシクロヘキシルメタン−4,4−ジイソシアネート、HMDIは1,6−ヘキサメチレン−ジイソシアネート、FECl3は塩化第二鉄、DABCOはトリエチレンジアミン、SnOct2はオクタン酸第一錫である。
重合時間が製造されるポリマーに及ぼす効果を、トリプル検出SEC(triple detection Size Exclution Chromatography)で調査した。ポリマーB及びCについて、重合時間に応じた分子量を測定した。結果を図1に示す。ポリマーの分子量は、レオロジー(rheology)、溶融流れ(melt flow)、及び力学的特性を決定するので、分子量測定が重要であることは明らかである。
実施例1において重合触媒は塩化第二鉄を用いたが、ポリマーNではDABCOとSnOct2、ポリマーMではDABCOが用いられ、ポリマーHでは触媒なしで重合が行われた(表1参照)。
ジシクロヘキシルメタン−4,4−ジイソシアネート(DMDI)の代わりに、ポリマーF、G、H、I、K、L、M、N、O、P、Q及びRでは1,6−ヘキサメチレン−ジイソシアネート(HMDI)を用いて実施例1と同様に重合を行なった(表1参照)。
表1に記載したポリマーについて適当な溶媒を見付けるために、異なる溶媒に溶解した。溶解度試験は、室温で24時間実施した。選択したポリマーの溶解度の結果を表2に示す。
選択したポリマーについて、水、エタノール、イソプロピルアルコール(IPA)、及びIPAと水の50%混合物中で、ポリマーに吸収される溶媒の量を測定する膨潤測定を行なった。10試料の膨潤の平均値として算出した結果を表3に示す。算出に使用した式は下記の通りである。
膨潤率(%)={(膨潤重量−乾燥重量)/乾燥重量}×100
製造したポリマーのショア硬度をタイプAとタイプDのデュロメータ(Durometer)を用い測定した。デュロメータAとDは、それぞれ軟質と硬質のゴムの弾力性を測定するために一般に用いられる。これらの測定は当業者によく知られている。4回測定した平均値の結果を表4に示す。
表1から選択したポリマーを加工前に真空下で一晩乾燥した。圧縮成形機の上部板と下部板の温度を目的の加工温度に設定した。型と熱した板の間に二枚のテフロン(登録商標)シートを配置した。3〜5分間溶融した後、170〜200barsの加圧下に30〜120秒間保持した。所定量のポリマーを型に満たした。室温まで冷却した後、試料(大きさ30mm×10mm×1mmのペッサリー)を機械的に型抜きし、分析用として冷凍庫に保存した。フィルム加工条件を表5に示す。
2つの異なる薬物であるフルコナゾール(fluconazole)とオキシブチニン(oxybutynin)を、選択したポリマーに担持した。実験用16mm同方向回転二軸押出機によりポリマーに担持した。薬物担持条件を表6に示す。
押出成形した担持ポリマーのインビトロでの薬物放出特性を、溶出試験により測定した。押出成形した担持ポリマーから放出したフルコナゾールとオキシブチニンの量を、短期放出の場合は米国薬局方(USP)のパドル法、長期放出の場合はエルレンマイヤーボトル(Erlenmeyer bottle)を用いた振とう培養法に基づく溶出試験により検討した。米国薬局方(USP)のパドル法の技術は、Distek社の溶出試験機(型番;model 2100C)(回転速度50rpmのパドル)が蠕動ポンプ(Icalis peristaltic pump)を介して分光光度計(Unicam UV500)に接続している自動UV(紫外)溶出システムで構成される。このシステムをDsolve(ソフトウエア)を用いて操作した。振とう培養法では、試料は手動で扱われ、分光光度計(Unicam UV500)により試料を測定した。実験条件は温度:37℃、溶出液:脱イオン化し脱気した水500ml。
薬物の種類を変えると、異なるプロファイルが得られた。フルコナゾールとオキシブチニンをポリマーAに担持した。標準化した溶出プロファイルを図3に示す。実施例10と同様の溶出試験法を用い、放出曲線を測定した。
溶出試験により、担持量増加の影響を検討した。異なる薬物量がポリマーAの放出特性に及ぼす影響を調査した。結果を図4に示す。フルコナゾールの担持量を20重量%から50重量%に増やした。実施例10と同様の溶出試験法を用い、放出曲線を測定した。
ポリマーAとポリマーCから得られたフルコナゾール放出プロファイルを、架橋ポリマー及び線状高膨潤ポリウレタンポリマーから得られた放出プロファイルと比較した結果を図5に示す。拡散担持架橋ポリマー(架橋17重量%フルコナゾール(crosslinked 17wt% fluconazole))は欧州特許出願公開第0016652号及び欧州特許出願公開第0016654号の特許明細書に記載がある。一方、線状高膨潤ポリマーは国際公開公報第2004/029125号パンフレットの特許明細書に記載されており、押出技術(高膨潤率20重量%フルコナゾール(high %SW 20wt% fluconazole))と同様に、拡散を用い担持された(高膨潤率17重量%フルコナゾール(high %SW 17wt% fluconazole))。実施例10と同様の溶出試験法を用い、放出曲線を測定した。これらの新規のポリマーは、図5に示すように、薬物放出を非常に良好に制御することが可能である。
Claims (16)
- (a)ポリエチレングリコール(PEG)またはポリプロピレングリコール(PPG)、
(b)PEG−PPG−PEGブロック共重合体またはPPG−PEG−PPGブロック共重合体、
(c)二官能性化合物、及び
(d)二官能性イソシアネーを共に反応して得られる線状ポリマー。 - ポリエチレングリコールが、分子量400〜2000の線状ポリエチレングリコールである請求項1に記載の線状ポリマー。
- ポリプロピレングリコールが、分子量400〜2000の線状ポリプロピレングリコールである請求項1に記載の線状ポリマー。
- ブロック共重合体の分子量が200〜14,000である先行するいずれかの請求項に記載の線状ポリマー。
- 二官能性化合物(c)がジオールである先行するいずれかの請求項に記載の線状ポリマー。
- ジオールが、炭素数5〜20のジオールである請求項5に記載の線状ポリマー。
- ジオールが、炭素数8〜15のジオールである請求項6に記載の線状ポリマー。
- ジオールが、1,6−へキサンジオール、1,10−デカンジオール、1,12−ドデカンジオールまたは1,16−ヘキサデカンジオールである請求項6に記載の線状ポリマー。
- 二官能性イソシアネート(d)が、ジシクロヘキシルメタン−4,4−ジイソシアネート、ジフェニルメタン−4,4−ジイソシアネートまたは1,6−へキサメチレンジイソシアネートである先行するいずれかの請求項に記載の線状ポリマー。
- (a):(b):(c):(d)の組成比が、当量換算でそれぞれ0.01〜1:0.01〜1:1:1.02〜3の範囲内である先行するいずれかの請求項に記載の線状ポリマー。
- ポリエチレングリコール(PEG)またはポリプロピレングリコール(PPG)、及びブロック共重合体を、二官能性化合物と共に真空下85〜100℃で、溶解、乾燥し、その後二官能性イソシアネートを添加することを含む先行するいずれかの請求項に記載の線状ポリマーの製造方法。
- 請求項1に記載の線状ポリマーと活性剤を含む放出制御組成物。
- 固形製剤に加工された請求項12に記載の組成物。
- 固形製剤が、座剤、膣リングもしくはペッサリー、口腔挿入剤、または経皮吸収型パッチである請求項13に記載の組成物。
- 固形製剤が、インプラントである請求項13に記載の組成物。
- 活性剤の分子量が、200〜20,000である請求項12〜15のいずれかに記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0613638.6A GB0613638D0 (en) | 2006-07-08 | 2006-07-08 | Polyurethane elastomers |
GB0613638.6 | 2006-07-08 | ||
PCT/GB2007/002415 WO2008007046A1 (en) | 2006-07-08 | 2007-06-27 | Polyurethane elastomers |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013043282A Division JP5639673B2 (ja) | 2006-07-08 | 2013-03-05 | 放出制御組成物 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009542831A true JP2009542831A (ja) | 2009-12-03 |
JP2009542831A5 JP2009542831A5 (ja) | 2012-09-20 |
JP5307710B2 JP5307710B2 (ja) | 2013-10-02 |
Family
ID=36926730
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009517399A Active JP5307710B2 (ja) | 2006-07-08 | 2007-06-27 | ポリウレタンエラストマー |
JP2013043282A Active JP5639673B2 (ja) | 2006-07-08 | 2013-03-05 | 放出制御組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013043282A Active JP5639673B2 (ja) | 2006-07-08 | 2013-03-05 | 放出制御組成物 |
Country Status (15)
Country | Link |
---|---|
US (2) | US8361272B2 (ja) |
EP (1) | EP2038325B1 (ja) |
JP (2) | JP5307710B2 (ja) |
CN (1) | CN101484495B (ja) |
AT (1) | ATE498643T1 (ja) |
AU (1) | AU2007274119B2 (ja) |
BR (1) | BRPI0713481B8 (ja) |
CA (1) | CA2656788C (ja) |
DE (1) | DE602007012545D1 (ja) |
DK (1) | DK2038325T3 (ja) |
ES (1) | ES2363704T3 (ja) |
GB (1) | GB0613638D0 (ja) |
PL (1) | PL2038325T3 (ja) |
PT (1) | PT2038325E (ja) |
WO (1) | WO2008007046A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013543763A (ja) * | 2010-11-12 | 2013-12-09 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデーション | 潤滑剤の制御送達のための膣内デバイス |
JP2014520896A (ja) * | 2011-07-20 | 2014-08-25 | エフ. カイザー,パトリック | 薬物送達のための膣内デバイス |
JPWO2013137290A1 (ja) * | 2012-03-13 | 2015-08-03 | 住友精化株式会社 | 化粧料組成物 |
KR20160097288A (ko) * | 2013-12-10 | 2016-08-17 | 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 | 고탄성 열가소성 폴리우레탄 |
KR20170080671A (ko) * | 2014-11-07 | 2017-07-10 | 훼링 비.브이. | 퀴나골라이드를 포함하는 약물-디바이스 유닛 |
WO2019111839A1 (ja) * | 2017-12-04 | 2019-06-13 | 住友精化株式会社 | 揮発性物質放散用組成物 |
JP2022091999A (ja) * | 2014-04-01 | 2022-06-21 | ポリ-メッド インコーポレイテッド | 避妊具及び関連した器具 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
US8637629B2 (en) * | 2007-01-18 | 2014-01-28 | Lubrizol Advanced Materials, Inc. | High moisture vapor transmissive polyurethanes |
US20110045076A1 (en) | 2008-01-25 | 2011-02-24 | Kiser Patrick F | Linear order release polymer |
US20090233887A1 (en) * | 2008-03-12 | 2009-09-17 | Shalaby Shalaby W | Hydroswellable, Segmented, Aliphatic Polyurethanes and Polyurethane Ureas |
FI123146B (fi) * | 2009-10-01 | 2012-11-30 | Bayer Schering Pharma Oy | Kohdunsisäinen järjestelmä |
US8940799B2 (en) * | 2010-03-25 | 2015-01-27 | Medtronic Xomed, Inc. | Adjusting drug loading in polymeric materials |
US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
EP3052084A1 (en) * | 2013-09-30 | 2016-08-10 | Universiteit Gent | Polyurethanes as oral drug delivery platform |
TW201527422A (zh) * | 2013-10-15 | 2015-07-16 | Lubrizol Advanced Mat Inc | 以無錫觸媒製造之熱塑性聚胺基甲酸酯 |
JP5955922B2 (ja) * | 2013-11-11 | 2016-07-20 | 三洋化成工業株式会社 | 水等価ファントム材用ポリウレタン樹脂 |
US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
MX2017005597A (es) | 2014-10-31 | 2017-06-23 | Lubrizol Advanced Mat Inc | Pelicula de poliuretano termoplastico para la liberacion de agentes activos a superficies de piel. |
US11202986B2 (en) * | 2017-10-09 | 2021-12-21 | Ali Pournaghshband Isfahani | Plasticization-resistant polyurethane membrane and preparation method thereof |
WO2023031218A1 (en) | 2021-08-31 | 2023-03-09 | Ferring B.V. | Diagnosis and treatment of ectopic endometriosis |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0753663A (ja) * | 1993-07-30 | 1995-02-28 | Takiron Co Ltd | 経皮吸収製剤用基剤ポリマー |
JPH08508314A (ja) * | 1993-04-01 | 1996-09-03 | ブリティッシュ・テクノロジー・グループ・リミテッド | ランダムブロツクコポリマー |
JP2001501232A (ja) * | 1996-09-20 | 2001-01-30 | バイエル・アクチエンゲゼルシヤフト | 活性物質含有の熱可塑性ポリウレタン |
JP2002088571A (ja) * | 2000-09-11 | 2002-03-27 | Du Pont Toray Co Ltd | ポリウレタン繊維の製造方法 |
JP2005534732A (ja) * | 2002-06-14 | 2005-11-17 | ポリメーレクスペール エス アー | 熱感応性ポリマー及びそのポリマーから得られた熱可逆性ゲル |
JP2006500456A (ja) * | 2002-09-27 | 2006-01-05 | コントロールド・セラピューティクス(スコットランド)・リミテッド | 水膨潤性ポリマー |
Family Cites Families (319)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE505703C2 (sv) | 1995-12-15 | 1997-09-29 | Polyrand Ab | Linjär blockpolymer innefattande urea- och uretangrupper, förfarande för framställning av linjära blockpolymerer samt användning av blockpolymererna som implantat |
US3916898A (en) | 1964-05-20 | 1975-11-04 | Searle & Co | Administration of medicaments and the like |
US3487068A (en) | 1966-12-16 | 1969-12-30 | Upjohn Co | Lincomycin-2-phosphates,7-substituted compounds and salts thereof |
US3830907A (en) * | 1968-04-22 | 1974-08-20 | Searle & Co | Compositions for the sustained release of 17alpha-ethyl-19-nortestosterone |
US3860701A (en) * | 1968-04-22 | 1975-01-14 | Searle & Co | Method for use and compositions of 11-lower alkyl steroids and drug delivery system for the controlled elution of 11-lower alkyl steroids |
US3565991A (en) * | 1968-04-22 | 1971-02-23 | Searle & Co | Methods for use and compositions of 17alpha-ethyl-19-nortestosterone and carriers for the sustained release of steroids |
US3639157A (en) | 1968-07-18 | 1972-02-01 | Bayer Ag | Process for finishing textile materials with a polymer of a vinyl compound and the reaction product of a polyol and an organic polyisocyanate |
US3948262A (en) * | 1969-04-01 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US3967618A (en) * | 1969-04-01 | 1976-07-06 | Alza Corporation | Drug delivery device |
US3734097A (en) * | 1969-04-01 | 1973-05-22 | Alza Corp | Therapeutic adhesive tape |
US3993073A (en) | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
US3896819A (en) * | 1969-04-01 | 1975-07-29 | Alejandro Zaffaroni | IUD having a replenishing drug reservoir |
US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
US3845761A (en) * | 1970-06-02 | 1974-11-05 | Alza Corp | Intrauterine contraceptive anti-fertility device for the management of reproduction |
US3737521A (en) * | 1970-12-09 | 1973-06-05 | Goodrich Co B F | Formulation for sustained release of a biological agent |
US3760805A (en) * | 1971-01-13 | 1973-09-25 | Alza Corp | Osmotic dispenser with collapsible supply container |
US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
US4034756A (en) * | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
US3941880A (en) * | 1971-02-22 | 1976-03-02 | G. D. Searle & Co. | Method for use of 11-lower alkyl steroids |
US3731683A (en) * | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
US3881043A (en) | 1971-06-21 | 1975-04-29 | Ppg Industries Inc | Laminated safety windshields |
US4041208A (en) | 1971-06-21 | 1977-08-09 | Ppg Industries, Inc. | Transparent, impact-resistant polyesterurethane laminates |
US3931113A (en) | 1971-06-21 | 1976-01-06 | Ppg Industries, Inc. | Impact-resistant thermoplastic polyester urethanes |
US3892842A (en) * | 1971-09-01 | 1975-07-01 | Alza Corp | Intrauterine contraceptive device for releasing steroid having double bond functionality |
US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3921636A (en) | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
US3867933A (en) * | 1973-03-06 | 1975-02-25 | Tecna Corp | Intrauterine device and process of making the same |
US4036227A (en) * | 1973-04-25 | 1977-07-19 | Alza Corporation | Osmotic releasing device having a plurality of release rate patterns |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
FR2250520B1 (ja) * | 1973-11-09 | 1977-04-15 | Cournut Rene | |
US3901852A (en) | 1974-07-29 | 1975-08-26 | Upjohn Co | Thermoplastic polyurethanes prepared from 4,4'-methylenebis (phenyl isocyanate) |
US3993072A (en) | 1974-08-28 | 1976-11-23 | Alza Corporation | Microporous drug delivery device |
US4096238A (en) * | 1974-12-23 | 1978-06-20 | Alza Corporation | Method for administering drug to the gastrointestinal tract |
US4018918A (en) | 1975-05-20 | 1977-04-19 | The Upjohn Company | Topical clindamycin preparations |
GB1479987A (en) | 1975-06-20 | 1977-07-13 | Interox Chemicals Ltd | Polyurethanes |
US4235988A (en) | 1976-12-13 | 1980-11-25 | Imperial Chemical Industries Limited | Delivery means for biologically active agents |
GB1551620A (en) | 1976-12-13 | 1979-08-30 | Ici Ltd | Delivery means for biologically active agents |
US4289757A (en) | 1978-02-28 | 1981-09-15 | The Upjohn Company | Method for treating inflammation |
US4205115A (en) | 1978-04-19 | 1980-05-27 | Ppg Industries, Inc. | Polyester coating composition |
US4215691A (en) * | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
US4286587A (en) * | 1978-10-11 | 1981-09-01 | Alza Corporation | Vaginal drug delivery system made from polymer |
US4237885A (en) | 1978-10-23 | 1980-12-09 | Alza Corporation | Delivery system with mated members for storing and releasing a plurality of beneficial agents |
US5079009A (en) | 1979-03-21 | 1992-01-07 | National Research Development Corporation | Controlled release compositions including polyethylene oxide with urethane cross-linking |
US5017382A (en) | 1979-03-21 | 1991-05-21 | National Research Development Corporation | Controlled release compositions (II) |
AU537741B2 (en) | 1979-03-21 | 1984-07-12 | British Technology Group Limited | Controlled release compositions |
US4250611A (en) * | 1979-04-19 | 1981-02-17 | Alza Corporation | Process for making drug delivery device with reservoir |
US4264757A (en) | 1979-06-26 | 1981-04-28 | Union Carbide Corporation | Radiation-curable allyl- or vinyl capped polycaprolactone compositions |
US4402695A (en) * | 1980-01-21 | 1983-09-06 | Alza Corporation | Device for delivering agent in vagina |
US4731289A (en) | 1980-02-14 | 1988-03-15 | Ppg Industries, Inc. | Abrasion resistant polyurethane coatings for rigid plastics |
US4276405A (en) | 1980-03-28 | 1981-06-30 | Union Carbide Corporation | Low-energy-curable coatings compositions |
DE3017989C2 (de) * | 1980-05-10 | 1982-05-19 | IPOS Gesellschaft für integrierte Prothesen-Entwicklung und orthopädietechnischen Service mbH & Co KG, 2120 Lüneburg | "Auffangbeutel für künstliche Darmausgänge" |
AU558611B2 (en) | 1981-02-03 | 1987-02-05 | Bayer Aktiengesellschaft | Polyurethane gel |
US4466936A (en) | 1981-02-03 | 1984-08-21 | Bayer Aktiengesellschaft | Production of molds using gel compositions with depot action based on a polyurethane matrix and relatively high molecular weight polyols |
JPS57155230A (en) | 1981-02-27 | 1982-09-25 | Daicel Chem Ind Ltd | Lactone polymer having narrow molecular weight distribution and its preparation |
JPS57185313A (en) | 1981-05-08 | 1982-11-15 | Daicel Chem Ind Ltd | Polyurethane and its preparation |
US4426485A (en) | 1982-06-14 | 1984-01-17 | Union Carbide Corporation | Polymers with hydrophobe bunches |
JPS5948409A (ja) | 1982-09-10 | 1984-03-19 | Teikoku Seiyaku Kk | 矯正的歯牙移動促進剤 |
US4438225A (en) | 1983-04-12 | 1984-03-20 | Henkel Corporation | Polyester polyols from bishydroxymethyl tricyclo compounds and caprolactone and polyurethanes based thereon |
GB8319766D0 (en) | 1983-07-22 | 1983-08-24 | Graham N B | Controlled release device |
FR2557576B1 (fr) | 1984-01-03 | 1988-06-03 | Gould Francis | Composition d'acrylate de polyurethane hydrophile, son procede de preparation et son utilisation comme pansement pour brulures, implant, contraceptif, dispositif intra-uterin, canule, systeme d'application orale, membrane permeable aux gaz, prothese de la cornee, pansement chirurgical, membrane de dialyse, lentille de contact et enrobage de coques de bateau |
US4694238A (en) * | 1984-01-10 | 1987-09-15 | Peter Norton | Dual voltage power supply system for vehicles |
GB8403138D0 (en) | 1984-02-07 | 1984-03-14 | Graham N B | Sustained release of active ingredient |
US4503216A (en) | 1984-02-21 | 1985-03-05 | Eastman Kodak Company | Hydroxyl-terminated polyether-esters |
US4568741A (en) | 1984-05-15 | 1986-02-04 | The Upjohn Company | Synthesis of 7-halo-7-deoxylincomycins |
EP0180264A1 (en) * | 1984-10-12 | 1986-05-07 | Akzo N.V. | Release system for two or more active substances |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
JPS61250019A (ja) | 1985-04-27 | 1986-11-07 | Bridgestone Corp | 微小気泡質状ポリウレタンエラストマ−の製造方法 |
JPS6257467A (ja) | 1985-09-06 | 1987-03-13 | Asahi Glass Co Ltd | コ−テイング剤組成物 |
US4707495A (en) | 1985-10-28 | 1987-11-17 | Ortho Pharmaceutical | Peptic ulcer treatment method |
US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5731303A (en) * | 1985-12-04 | 1998-03-24 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery compositions |
US4917686A (en) | 1985-12-16 | 1990-04-17 | Colorado Biomedical, Inc. | Antimicrobial device and method |
IE59361B1 (en) | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
US5219885A (en) | 1987-02-16 | 1993-06-15 | Froelich Juergen | Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration |
US4804691A (en) | 1987-08-28 | 1989-02-14 | Richards Medical Company | Method for making a biodegradable adhesive for soft living tissue |
EP0310037B1 (en) | 1987-09-28 | 1993-07-14 | Kuraray Co., Ltd. | Leather-like sheet material and method of producing same |
US5035891A (en) | 1987-10-05 | 1991-07-30 | Syntex (U.S.A.) Inc. | Controlled release subcutaneous implant |
JP2538953B2 (ja) * | 1987-11-17 | 1996-10-02 | 三菱重工業株式会社 | 工業用ロボットのバランス機構 |
IE60383B1 (en) | 1988-05-27 | 1994-07-13 | Elan Corp Plc | Controlled release pharmaceutical formulation |
US5219663A (en) | 1988-06-22 | 1993-06-15 | Hitachi Maxell, Ltd. | Magnetic recording medium having a magnetic layer formed from an aromatic polycarbonate polyurethane resin |
JPH024736A (ja) | 1988-06-22 | 1990-01-09 | Hitachi Maxell Ltd | ポリカーボネートポリオール、芳香族ポリカーボネートポリウレタン樹脂、コーティング材、キャストフィルム、磁気記録媒体 |
JP2613441B2 (ja) | 1988-07-18 | 1997-05-28 | トヨタ自動車株式会社 | 発泡ポリウレタンの製法 |
US5000955A (en) | 1988-07-29 | 1991-03-19 | Tyndale Plains-Hunter Ltd. | Thermally reversible polyurethane hydrogels and cosmetic, biological and medical uses |
US4933418A (en) | 1988-08-10 | 1990-06-12 | Ormco Corporation | Stain-resistant orthodontic device |
US4895934A (en) | 1988-08-22 | 1990-01-23 | E. I. Du Pont De Nemours And Company | Process for the preparation of clindamycin phosphate |
SE463851B (sv) | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
US5470829A (en) | 1988-11-17 | 1995-11-28 | Prisell; Per | Pharmaceutical preparation |
FR2641786B1 (fr) | 1989-01-19 | 1992-09-11 | Sami | Composition de polymere d'urethanne et preparation d'articles a partir de ces polymeres |
DE3903538A1 (de) | 1989-02-07 | 1990-08-16 | Basf Ag | Herstellung von emulgatorfreien, waessrigen polyurethandispersionen |
ES2010145A6 (es) * | 1989-03-02 | 1989-10-16 | Uriach & Cia Sa J | Procedimiento para la obtencion de derivados de la 2-picolilamina. |
US5888930A (en) | 1989-03-27 | 1999-03-30 | Bend Research, Inc. | Asymmetric microporous beads for controlled release |
US5002540A (en) * | 1989-05-22 | 1991-03-26 | Warren Kirschbaum | Intravaginal device and method for delivering a medicament |
US5034461A (en) | 1989-06-07 | 1991-07-23 | Bausch & Lomb Incorporated | Novel prepolymers useful in biomedical devices |
US5061254A (en) | 1989-06-21 | 1991-10-29 | Becton, Dickinson And Company | Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter |
US5178874A (en) | 1989-06-30 | 1993-01-12 | Smithkline Beechman Corporation | Intermittent release dosage form |
US5110598A (en) | 1989-06-30 | 1992-05-05 | Smithkline Beecham Corp. | Intermittent release dosage form |
JP2844474B2 (ja) | 1989-07-19 | 1999-01-06 | ダイセル化学工業株式会社 | ポリウレタンの製造方法 |
GB8918589D0 (en) * | 1989-08-15 | 1989-09-27 | Graham Neil B | Polymeric compositions |
US5118779A (en) | 1989-10-10 | 1992-06-02 | Polymedica Industries, Inc. | Hydrophilic polyurethane elastomers |
DE4006521A1 (de) | 1990-03-02 | 1991-09-05 | Bayer Ag | Zuckerhaltige polymere zur umhuellung und einbettung von arzneistoffen |
DE4019171A1 (de) | 1990-06-15 | 1991-12-19 | Henkel Kgaa | Beschichtungsmittel |
GB2244920B (en) | 1990-06-16 | 1994-05-25 | British Aerospace | A contraceptive device |
US5130126A (en) | 1990-07-09 | 1992-07-14 | Nippon Oil & Fats Co., Ltd. | Polymer-drug conjugate and a method of producing it |
JP2611073B2 (ja) | 1990-07-26 | 1997-05-21 | モンサント カンパニー | 新規ポリアミンの製造方法 |
US5326632A (en) | 1990-08-07 | 1994-07-05 | Komatsu Seiren Co., Ltd. | Moisture-permeable waterproof fabric and process for production thereof |
US5114718A (en) | 1990-09-20 | 1992-05-19 | The Procter & Gamble Company | Sustained release compositions for treating periodontol disease |
JPH05239205A (ja) | 1991-02-13 | 1993-09-17 | Ajinomoto Co Inc | ポリアミノ酸ウレタン樹脂 |
GB2254002B (en) | 1991-01-16 | 1995-03-22 | Controlled Therapeutics | Retrievable pessary |
US5652274A (en) | 1991-03-01 | 1997-07-29 | Martin; Alain | Therapeutic-wound healing compositions and methods for preparing and using same |
US5159047A (en) | 1991-06-14 | 1992-10-27 | E. I. Du Pont De Nemours And Company | Coatings containing caprolactone oligomer polyols |
CA2071137A1 (en) | 1991-07-10 | 1993-01-11 | Clarence C. Lee | Composition and method for revitalizing scar tissue |
US5176907A (en) * | 1991-08-13 | 1993-01-05 | The Johns Hopkins University School Of Medicine | Biocompatible and biodegradable poly (phosphoester-urethanes) |
US5322063A (en) | 1991-10-04 | 1994-06-21 | Eli Lilly And Company | Hydrophilic polyurethane membranes for electrochemical glucose sensors |
US5252602A (en) | 1991-10-11 | 1993-10-12 | Rafeul Alam | Effects of misoprostol on allergic responses |
EP0608320B1 (en) | 1991-10-16 | 1998-01-28 | Richardson-Vicks, Inc. | Enhanced skin penetration system for improved topical delivery of drugs |
US6117843A (en) | 1992-02-18 | 2000-09-12 | Lloyd J. Baroody | Compositions for the treatment of acne containing clindamycin and benzoyl peroxide |
US5650171A (en) | 1992-04-29 | 1997-07-22 | Penederm, Inc. | Retinoic acid-containing polyether-polyurethane compositions |
US5578643A (en) | 1992-05-20 | 1996-11-26 | Loyola University Of Chicago | Protective prostaglandins for use in conjunction with chemotherapeutic agents |
JP3119533B2 (ja) | 1992-05-27 | 2000-12-25 | 日本ペイント株式会社 | 耐チッピング性塗料組成物 |
US5710215A (en) | 1992-06-15 | 1998-01-20 | Ebnother Ag | Method and material mixture for manufacture of reactive hotmelts |
US5310759A (en) | 1992-08-12 | 1994-05-10 | Bockman Richard S | Methods of protecting and preserving connective and support tissues |
AU5541594A (en) * | 1992-10-21 | 1994-05-09 | Gynetech Laboratories, Inc. | Vaginal sponge delivery system |
US6328991B1 (en) | 1992-10-21 | 2001-12-11 | John Myhling | Composition and method for prevention of sexually transmitted diseases, including aids |
US5747582A (en) | 1992-10-29 | 1998-05-05 | Bayer Aktiengesellschaft | Aqueous coating compositions and their use for the preparation of coatings that are permeable to water vapor |
DE4241118A1 (de) | 1992-12-07 | 1994-06-09 | Basf Ag | Verwendung von kationischen Polyurethanen und Polyharnstoffen als Hilfsmittel in kosmetischen und pharmazeutischen Zubereitungen |
DE4242687B8 (de) | 1992-12-17 | 2006-01-12 | Henkel Kgaa | Hydrophile Polyurethane |
DE4315173A1 (de) | 1992-12-23 | 1994-06-30 | Bayer Ag | Reine, insbesondere katalysatorfreie Polyurethane |
US5324746A (en) | 1993-02-12 | 1994-06-28 | Mckee Rex N | Method of treating damaged mucosal and epithelial tissues with misoprostol |
US5328954A (en) | 1993-04-16 | 1994-07-12 | Icet, Inc. | Encrusting and bacterial resistant coatings for medical applications |
FR2705567A1 (fr) | 1993-05-25 | 1994-12-02 | Smith & Nephew Laboratoires Fi | Microparticules, procédé de préparation et application aux pansements. |
US6084038A (en) | 1993-07-28 | 2000-07-04 | Basf Corporation | Curable coating compositions containing blends of carbamate-functional compounds |
US5744550A (en) | 1994-11-03 | 1998-04-28 | Basf Corporation | Curable coating compositions containing carbamate additives |
US5770650A (en) | 1995-10-06 | 1998-06-23 | Basf Corporation | Curable compositions for coatings |
US6080825A (en) | 1993-07-28 | 2000-06-27 | Basf Corporation | Curable coating compositions containing blends of carbamate-functional compounds |
US6160058A (en) | 1993-07-28 | 2000-12-12 | Basf Corporation | Curable coating compositions containing blends of carbamate-functional compounds |
US5994479A (en) | 1993-07-28 | 1999-11-30 | Basf Corporation | Curable coating compositions containing blends of carbamate-functional compounds |
US5854385A (en) | 1995-10-06 | 1998-12-29 | Basf Corporation | Coating compositions with low molecular weight carbamate or urea component |
US5726244A (en) | 1995-08-10 | 1998-03-10 | Basf Corporation | Aqueous coating compositions for environmental etch resistant coatings |
US5777048A (en) | 1996-06-20 | 1998-07-07 | Basf Corporation | Method for modified aminoplast compounds, aminoplasts obtained thereby and coatings containing the same |
US5827930A (en) | 1995-10-06 | 1998-10-27 | Basf Corporation | Curable coating composition |
US5792810A (en) | 1995-10-06 | 1998-08-11 | Basf Corporation | Curable coating composition including compound having carbamate and hydroxyl functionality |
US6423788B1 (en) | 1995-10-06 | 2002-07-23 | Basf Corporation | Curable coating composition |
ES2110154T3 (es) | 1993-07-28 | 1998-02-01 | Basf Corp | Composicion de recubrimiento curable. |
US5514698A (en) | 1994-03-21 | 1996-05-07 | Ortho Pharmaceutical Corporation | Antifungal vaginal cream composition |
US5472785A (en) | 1994-04-12 | 1995-12-05 | Minnesota Mining And Manufacturing Company | Reactive wax-containing moisture curable hot melt composition |
US5985859A (en) | 1994-04-14 | 1999-11-16 | The University Of Alabama | Methods of inhibiting bacterial sialidase |
IL109539A0 (en) | 1994-05-03 | 1994-08-26 | Yissum Res Dev Co | Substained-release pharmaceutical system for the delivery of antioxidants |
EP0797604B1 (de) | 1994-05-25 | 1999-12-08 | Henkel Kommanditgesellschaft auf Aktien | Feuchtigkeitshärtender polyurethan-schmelzklebstoff |
US5681278A (en) | 1994-06-23 | 1997-10-28 | Cormedics Corp. | Coronary vasculature treatment method |
GB9419566D0 (en) | 1994-09-27 | 1994-11-16 | El Refaey Hazem | Oral prostagladins for the routine management of the third stage of labour |
IL116433A (en) * | 1994-12-19 | 2002-02-10 | Galen Chemicals Ltd | INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS |
US5659003A (en) | 1994-12-21 | 1997-08-19 | Basf Corporation | Polyurethane polymer or oligomer having carbamate groups, method for its preparation, and coating composition |
US20030158369A1 (en) | 1995-02-02 | 2003-08-21 | Slagel Edwin C. | Impact resistant polyurethane and method of manufacture thereof |
GB9506946D0 (en) | 1995-04-04 | 1995-05-24 | Univ Strathclyde | Microgels |
TR199701433T1 (xx) | 1995-05-26 | 1998-03-21 | Henkel Kommanditgesellschaft Auf Aktien | Yap��t�rma y�ntemi. |
DK0828495T3 (da) | 1995-06-01 | 2003-02-24 | Searle & Co | Misoprostolholdige faste stabiliserede dispersioner |
US6413536B1 (en) * | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
US5733538A (en) | 1995-06-07 | 1998-03-31 | Thoratec Laboratories, Inc. | Surface-modifying copolymers having cell adhesion properties |
US7833543B2 (en) * | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
US5968542A (en) * | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
US5900433A (en) | 1995-06-23 | 1999-05-04 | Cormedics Corp. | Vascular treatment method and apparatus |
US5948416A (en) | 1995-06-29 | 1999-09-07 | The Procter & Gamble Company | Stable topical compositions |
CA2228118A1 (en) * | 1995-07-28 | 1997-02-13 | Focal, Inc. | Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents |
EP0857484A4 (en) | 1995-09-13 | 2000-12-06 | Nippon Shinyaku Co Ltd | PGE1- FREEZING DRIED PREPARATION AND METHOD FOR THE PRODUCTION THEREOF |
DE19541658A1 (de) | 1995-11-08 | 1997-05-15 | Basf Ag | Wasserlösliche oder wasserdispergierbare Pfropfpolymere, ihre Herstellung und ihre Verwendung |
EP0776921A3 (en) | 1995-12-01 | 1997-08-13 | Hokushin Corp | Method for the preparation of amorphous polymer chains of elastomers |
US6008312A (en) | 1995-12-01 | 1999-12-28 | Hokushin Corp | Method for producing millable polyurethanes and polyurethane elastomers |
AU713849B2 (en) | 1995-12-27 | 1999-12-09 | Janssen Sciences Ireland Uc | Bioadhesive solid dosage form |
US6521164B1 (en) | 1996-02-06 | 2003-02-18 | Parker-Hannifin Corporation | Injection-moldable thermoplastic polyurethane elastomer |
US5627254A (en) | 1996-05-03 | 1997-05-06 | The Dow Chemical Company | Rigid thermoplastic plyurethane comprising units of butane diol and a polyethylene glycol |
US5817343A (en) | 1996-05-14 | 1998-10-06 | Alkermes, Inc. | Method for fabricating polymer-based controlled-release devices |
JPH11513072A (ja) | 1996-07-01 | 1999-11-09 | ビーエーエスエフ、コーポレーション | カルバミン酸エステル添加剤を含む硬化性塗料組成物 |
US5972372A (en) * | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
US6184248B1 (en) | 1996-09-05 | 2001-02-06 | Robert K. K. Lee | Compositions and methods for treatment of neurological disorders and neurodegenerative diseases |
EP1006798A4 (en) | 1996-09-05 | 2003-03-05 | Massachusetts Inst Technology | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES |
US6130309A (en) | 1996-09-20 | 2000-10-10 | Tyndale Plains-Hunter, Ltd. | Hydrophilic polyether polyurethanes containing carboxylic acid |
NZ335208A (en) | 1996-11-04 | 2000-11-24 | Huntsman Ici Chem Llc | Rigid polyurethane foams |
AU739469B2 (en) | 1996-12-20 | 2001-10-11 | Alza Corporation | Gel composition and methods |
US5853767A (en) | 1997-01-02 | 1998-12-29 | Melman; Steven A. | Compositions for treating fungal, parasitic and/or bacterial infections, especially infections of organs such as the skin and vagina |
US20050208152A1 (en) | 1997-01-22 | 2005-09-22 | Marton Milankovits | Pharmaceutical compositions primarily for the treatment and prevention of genitourinary infections and their extragenital complications |
US6471955B1 (en) | 1997-04-04 | 2002-10-29 | Pharmacia Corporation | Ph-selective delivery system using crosslinked polymeric resins as vehicles |
US6221997B1 (en) | 1997-04-28 | 2001-04-24 | Kimberly Ann Woodhouse | Biodegradable polyurethanes |
US20020115814A1 (en) | 1997-04-28 | 2002-08-22 | Woodhouse Kimberly Ann | Incorporation by reference of co-pending application |
GR1002847B (el) | 1997-05-06 | 1998-01-27 | Χρηση της μισοπροστολης ή/και της μισοπροστολης οξυ για την παρασκευη φαρμακευτικου προιοντος για τη θεραπευτικη αντιμετωπιση των δυσλειτουργιων της στυσεως | |
JPH10332902A (ja) | 1997-05-27 | 1998-12-18 | Nippon Ee R C Kk | プラスチックレンズとその製造方法及びプライマー組成物 |
US6572874B1 (en) * | 1998-05-15 | 2003-06-03 | Umd, Inc. | Vaginal delivery of bisphosphonates |
ES2123466B1 (es) | 1997-06-11 | 1999-11-16 | Merquinsa Mercados Quimicos S | Termoplastico de poliuretano y procedimiento para su obtencion. |
US6416779B1 (en) | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
US6103765A (en) | 1997-07-09 | 2000-08-15 | Androsolutions, Inc. | Methods for treating male erectile dysfunction |
KR20010021625A (ko) | 1997-07-09 | 2001-03-15 | 추후보정 | 개선된 남성발기 기능장애 치료방법 및 그 조성물 |
CA2301659C (en) * | 1997-08-25 | 2003-12-02 | David Michael Simpson | Condensation copolymers having surpressed crystallinity |
DE19737348C2 (de) | 1997-08-27 | 2002-07-25 | Dan-Gabriel Vulpescu | Neue Clindamycin und Clotrimazol enthaltende pharmazeutische Zusammensetzung |
DE19742217A1 (de) | 1997-09-24 | 1999-04-01 | Henkel Kgaa | Hydrophiles, hochmolekulares Polyurethan, Klebstoffzusammensetzungen, die dieses enthalten sowie Verwendung dieses Polyurethans |
DE59807989D1 (de) | 1997-09-24 | 2003-05-22 | Henkel Kgaa | Polyurethan-klebstoff |
DE19744473A1 (de) | 1997-10-09 | 1999-04-15 | Basf Ag | Verwendung von wasserlöslichen oder wasserdispergierbaren Polyurethanen als Überzugsmittel oder Bindemittel für pharmazeutische Darreichungsformen |
US20020004529A1 (en) | 1997-10-20 | 2002-01-10 | Gary W. Neal | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
US6593369B2 (en) | 1997-10-20 | 2003-07-15 | Vivus, Inc. | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
US20020013304A1 (en) | 1997-10-28 | 2002-01-31 | Wilson Leland F. | As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness |
US20040014761A1 (en) | 1997-10-28 | 2004-01-22 | Place Virgil A. | Treatment of female sexual dysfunction with phosphodiesterase inhibitors |
US20050070516A1 (en) | 1997-10-28 | 2005-03-31 | Vivus Inc. | As-needed administration of an androgenic agent to enhance female desire and responsiveness |
US20040044080A1 (en) | 1997-10-28 | 2004-03-04 | Place Virgil A. | Treatment of dyspareunia with topically administered nitroglycerin formulations |
CA2306837C (en) | 1997-10-28 | 2007-05-08 | Asivi, Llc. | Treatment of female sexual dysfunction |
US5877216A (en) | 1997-10-28 | 1999-03-02 | Vivus, Incorporated | Treatment of female sexual dysfunction |
US20020099003A1 (en) | 1997-10-28 | 2002-07-25 | Wilson Leland F. | Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof |
US6046244A (en) | 1997-11-05 | 2000-04-04 | Nexmed Holdings, Inc. | Topical compositions for prostaglandin E1 delivery |
US6414028B1 (en) | 1997-11-05 | 2002-07-02 | Nexmed Holdings, Inc. | Topical compositions containing prostaglandin E1 |
ES2173635T3 (es) | 1997-11-17 | 2002-10-16 | Cosma Int Inc | Espaciador de panel soldado en proyeccion y metodo de fabricacion del mismo. |
ES2138918B1 (es) | 1997-11-20 | 2000-09-16 | Merquinsa Mercados Quimicos S | Termoplastico de poliuretano cristalino y metodo para su obtencion. |
US6022554A (en) | 1997-12-15 | 2000-02-08 | American Home Products Corporation | Polymeric microporous film coated subcutaneous implant |
DE19757569A1 (de) | 1997-12-23 | 1999-06-24 | Bayer Ag | Aliphatische, emissionsarme, sinterfähige thermoplastische Polyurethanformmassen |
US5959775A (en) | 1997-12-23 | 1999-09-28 | 3M Innovative Properties Company | Urethane/acrylate bead bond for retroreflective articles |
ATE302224T1 (de) * | 1998-01-28 | 2005-09-15 | Bristol Myers Squibb Co | Verfahren zur herstellung von polyurethanklebstoffen und hergestellte klebstoffe |
US6028057A (en) * | 1998-02-19 | 2000-02-22 | Thorn Bioscience, Llc | Regulation of estrus and ovulation in gilts |
ME00867B (me) | 1998-03-19 | 2008-08-07 | Merck Sharp & Dohme | Tečne polimerne smeše za kontrolisano oslobađanje bioaktivnih supstanci |
US5891915A (en) | 1998-05-01 | 1999-04-06 | Wysor; Michael S. | Method for enhancing female sexual response and an ointment therefor |
US6031002A (en) | 1998-05-01 | 2000-02-29 | Michael Ebert | Method for enhancing female sexual response and a composition therefor |
US6013637A (en) | 1998-06-12 | 2000-01-11 | Dermik Laboratories Inc. | Anti-acne method and composition |
US5942545A (en) | 1998-06-15 | 1999-08-24 | Macrochem Corporation | Composition and method for treating penile erectile dysfunction |
DE19847791A1 (de) | 1998-10-16 | 2000-04-20 | Bayer Ag | Wäßrige Polyurethandispersionen |
NL1010367C2 (nl) | 1998-10-21 | 2000-04-25 | Akzo Nobel Nv | Waterdampdoorlatende thermoplastische polyurethaanfilm. |
DE19849499A1 (de) | 1998-10-27 | 2000-05-04 | Basf Ag | Verfahren zur vollständigen Trocknung von Hydrogelen |
GB9826192D0 (en) | 1998-12-01 | 1999-01-20 | Controlled Theraputics Scotlan | Oral transmucosal delivery |
US20050004226A1 (en) | 1998-12-10 | 2005-01-06 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
US6825234B2 (en) | 1998-12-10 | 2004-11-30 | Nexmed (Holdings) , Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
US6486207B2 (en) | 1998-12-10 | 2002-11-26 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
DE10004723A1 (de) | 2000-02-03 | 2001-08-09 | Bayer Ag | Wässrige Sperrschicht auf Basis von Polyurethan-Disperionen |
US6545119B2 (en) | 1999-03-08 | 2003-04-08 | Toyo Boseki Kabushiki Kaisha | Magnetic recording media and thermoplastic polyurethane resins therefor |
WO2000059483A2 (en) | 1999-04-01 | 2000-10-12 | Alza Corporation | Transdermal drug delivery devices comprising a polyurethane drug reservoir |
DE19915932A1 (de) | 1999-04-09 | 2000-10-19 | Freudenberg Carl Fa | Thermoplastisch verarbeitbare Polyurethan-Formmasse |
US6607686B2 (en) | 1999-04-20 | 2003-08-19 | Callaway Golf Company | Thermosetting polyurethane material for a golf ball |
US6117024A (en) | 1999-04-20 | 2000-09-12 | Callaway Golf Company | Golf ball with polyurethane cover |
US6592472B2 (en) | 1999-04-20 | 2003-07-15 | Callaway Golf Company | Golf ball having a non-yellowing cover |
IT1312310B1 (it) | 1999-05-07 | 2002-04-15 | Recordati Ind Chimica E Farma | Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale |
TWI232111B (en) | 1999-08-06 | 2005-05-11 | Upjohn Co | Intravaginal clindamycin ovule composition |
US6642274B1 (en) | 1999-09-09 | 2003-11-04 | Gary W. Neal | Methods and compositions for preventing and treating prostate disorders |
US7105571B2 (en) | 2000-01-10 | 2006-09-12 | Nexmed Holdings, Inc. | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
US6323241B1 (en) | 2000-01-10 | 2001-11-27 | Nexmed (Holdings) Inc. | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
US6693135B2 (en) | 2000-01-10 | 2004-02-17 | Nexmed (Holdings) Incorporated | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
US20040110843A1 (en) | 2000-01-10 | 2004-06-10 | Nexmed (Holdings), Inc. | Methods of treatment of male erectile dysfunction |
IT1317735B1 (it) * | 2000-01-26 | 2003-07-15 | Nicox Sa | Sali di agenti antimicrobici. |
DE10028810A1 (de) | 2000-06-10 | 2001-12-20 | Henkel Kgaa | Polyurethan-Zusammensetzungen auf der Basis von Polyester-Block-Copolymeren |
US6803495B2 (en) | 2000-06-28 | 2004-10-12 | World Properties, Inc. | Polyurethane foam composition and method of manufacture thereof |
US6740333B2 (en) * | 2000-07-07 | 2004-05-25 | Anestic Aps | Suppository and composition comprising at least one polyethylene glycol |
DE10050137A1 (de) | 2000-10-11 | 2002-04-18 | Bayer Ag | Stabilisierte Mono- und Polyasparaginsäureester |
DE10051392A1 (de) | 2000-10-17 | 2002-04-18 | Bayer Ag | Elektroisolierlackbindemittel mit Harnstoff- und/oder Hydantoinstruktur |
JP5027962B2 (ja) | 2000-10-19 | 2012-09-19 | Dic株式会社 | 液状ウレタンプレポリマーの製造方法および樹脂組成物 |
US6811549B2 (en) | 2001-02-16 | 2004-11-02 | William H. Fleming | Administration of therapeutic or diagnostic agents using interlabial pad |
DE10112366B4 (de) | 2001-03-15 | 2006-06-08 | Bayer Materialscience Ag | Aliphatische thermoplastische Polyurethane und ihre Verwendung |
US6881788B2 (en) | 2001-08-21 | 2005-04-19 | Mitsui Takeda Chemicals, Inc. | Polyurethane resin water dispersion and aqueous polyurethane adhesive |
WO2003059373A2 (en) * | 2002-01-16 | 2003-07-24 | Ramot At Tel Aviv University Ltd. | Compositions and their use for enhancing and inhibiting fertilization |
CH697081A5 (de) | 2002-01-22 | 2008-04-30 | Andreas F Dr Schaub | Zusammensetzung für die Unterstützung der Geburt eines menschlichen Föten. |
WO2003065924A1 (en) * | 2002-02-08 | 2003-08-14 | Advanced Animal Technology Limited | Control of a biological function |
NZ517094A (en) | 2002-02-08 | 2005-03-24 | Advanced Animal Technology Ltd | Improvements in and relating to substance delivery device |
US6861503B2 (en) * | 2002-02-27 | 2005-03-01 | Poly-Med, Inc. | Interlinked solid polyethylene glycols and copolymers thereof |
US7358295B2 (en) | 2002-04-05 | 2008-04-15 | Lubrizol Advanced Materials, Inc. | Hybrid polymer composition, and article therefrom |
US7179481B2 (en) * | 2002-09-19 | 2007-02-20 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
CA2499447C (en) | 2002-10-28 | 2011-03-29 | Tyco Healthcare Group Lp | Fast curing compositions |
US20040142847A1 (en) | 2002-11-21 | 2004-07-22 | Rolf Bayersdoerfer | Detergent tablets with polyurethane coating |
US6841574B2 (en) | 2003-01-03 | 2005-01-11 | Nexmed Holdings, Inc. | Topical stabilized prostaglandin E compound dosage forms |
US20050181030A1 (en) | 2003-01-03 | 2005-08-18 | Mo Y. J. | Topical stabilized prostaglandin E compound dosage forms |
US20050013793A1 (en) | 2003-01-16 | 2005-01-20 | Beckman Eric J. | Biodegradable polyurethanes and use thereof |
GB0301577D0 (en) | 2003-01-23 | 2003-02-26 | Edko Pazarlama Tanitim Ltd Sti | Topical pharmaceutical and/or cosmetic dispense systems |
GB0306977D0 (en) | 2003-03-26 | 2003-04-30 | Metris Therapeutics Ltd | Device |
WO2004091579A1 (en) * | 2003-04-16 | 2004-10-28 | Pharmacia Corporation | Stabilized prostaglandin formulation |
ATE461681T1 (de) | 2003-04-29 | 2010-04-15 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
WO2004103159A2 (en) | 2003-05-14 | 2004-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for modulating endometrium |
US8399013B2 (en) * | 2003-06-26 | 2013-03-19 | Poly-Med, Inc. | Partially absorbable fiber-reinforced composites for controlled drug delivery |
US8404272B2 (en) | 2003-06-26 | 2013-03-26 | Poly-Med, Inc. | Fiber-reinforced composite rings for intravaginal controlled drug delivery |
WO2005004837A1 (en) * | 2003-07-10 | 2005-01-20 | Galen (Chemicals) Limited | Intravaginal drug delivery devices |
WO2005013906A2 (en) | 2003-08-08 | 2005-02-17 | Sri International | pH-RESPONSIVE FILM FOR INTRAVAGINAL DELIVERY OF A BENEFICIAL AGENT |
CA2540129A1 (en) | 2003-09-19 | 2005-03-31 | Drugtech Corporation | Pharmaceutical delivery system |
ATE289514T1 (de) | 2003-11-03 | 2005-03-15 | Peter-Hansen Volkmann | Vaginalpflegezusammensetzung |
EP1555278A1 (en) | 2004-01-15 | 2005-07-20 | Innocore Technologies B.V. | Biodegradable multi-block co-polymers |
MXPA06007493A (es) * | 2004-01-28 | 2007-04-17 | New Condensator Inc | Aparato para remover contaminantes de emisiones del carter. |
AU2005200368A1 (en) | 2004-02-03 | 2005-08-18 | Nitto Denko Corporation | Film base material for adhesive skin patch and adhesive skin patch |
DE102004008015A1 (de) | 2004-02-19 | 2005-09-08 | Cognis Deutschland Gmbh & Co. Kg | Verdickungsmittel für Polyurethanbasis |
EP1729783B2 (en) | 2004-03-24 | 2023-01-18 | Polynovo Biomaterials Pty Limited | Biodegradable polyurethane and polyurethane ureas |
AU2005231738A1 (en) * | 2004-03-26 | 2005-10-20 | Katz, David F. Mr | Bioresponsive polymer system for delivery of microbicides |
US8273847B2 (en) | 2004-03-29 | 2012-09-25 | Sanyo Chemical Industries, Ltd | Medical adhesive |
AU2005233643A1 (en) | 2004-04-15 | 2005-10-27 | The University Of Utah Research Foundation | Biodegradable and biocompatible PEG-based poly(ester-urethanes) |
US7485666B2 (en) * | 2004-06-17 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
US20060003950A1 (en) | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
DE102004031786A1 (de) | 2004-07-01 | 2006-01-26 | Cognis Deutschland Gmbh & Co. Kg | Verdickungsmittel auf Polyurethanbasis |
PT1768625E (pt) * | 2004-07-09 | 2011-04-18 | Hra Pharma Lab | Composições de libertação sustida contendo moduladores do receptor da progesterona |
CA2574933C (en) | 2004-07-26 | 2015-05-19 | Synthes (U.S.A.) | Biocompatible, biodegradable polyurethane materials with controlled hydrophobic to hydrophilic ratio |
GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
WO2006024138A1 (en) | 2004-08-30 | 2006-03-09 | Taro Pharmaceutical Industries Ltd. | A thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol |
US20060093675A1 (en) | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
GB0424526D0 (en) | 2004-11-05 | 2004-12-08 | Controlled Therapeutics Sct | Hydrogel delivery vehicle |
EP1853272A1 (en) * | 2005-02-03 | 2007-11-14 | Duramed Pharmaceuticals, Inc. | Compositions of unconjugated estrogens and methods for their use |
US7795467B1 (en) * | 2005-04-26 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyurethanes for use in medical devices |
TW200744610A (en) * | 2005-06-21 | 2007-12-16 | Organon Nv | New regimens for controlled drug delivery devices for contraception |
TW200727920A (en) * | 2005-06-21 | 2007-08-01 | Organon Nv | New regimens for oral monophasic contraceptives |
US8173593B2 (en) * | 2005-07-19 | 2012-05-08 | The Population Council, Inc. | Methods and compositions for emergency contraception using endothelin receptor antagonists |
CA2628598C (en) * | 2005-12-06 | 2015-02-24 | Tyco Healthcare Group Lp | Bioabsorbable surgical composition |
EP1960447A4 (en) * | 2005-12-08 | 2010-12-01 | Tyco Healthcare | BIOCOMPATIBLE SURGICAL COMPOSITIONS |
US20070148105A1 (en) | 2005-12-22 | 2007-06-28 | Donald Spector | Compositions and methods comprising magnetic particles for health use |
US20090061172A1 (en) | 2006-01-26 | 2009-03-05 | Komatsu Seiren Co., Ltd. | Polyurethane Resin Composition for Durable Moisture-Permeable Waterproof Sheet, Moisture-Permeable Waterproof Sheet and Method of Manufacturing the Same |
EP1994212A1 (de) | 2006-03-06 | 2008-11-26 | Basf Se | Vliesstoff auf der basis von thermoplastischem polyurethan |
EP2012803A4 (en) | 2006-04-20 | 2012-08-01 | Univ Utah Res Found | POLYMER COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF |
GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
US7717892B2 (en) * | 2006-07-10 | 2010-05-18 | Mcneil-Ppc, Inc. | Method of treating urinary incontinence |
BRPI0713203A2 (pt) | 2006-07-12 | 2012-04-03 | Controlled Therapeutics Scotland Ltda | inserto, métodos, embalagem, dispositivo recuperável e dispositivo inserìvel |
JP2010510286A (ja) * | 2006-11-22 | 2010-04-02 | ナームローゼ・フエンノートチヤツプ・オルガノン | 非ステロイド非イオン化親水性薬物の送達系 |
US7781651B2 (en) | 2007-04-30 | 2010-08-24 | Monsanto Technology Llc | Plants and seeds of corn variety CV715590 |
WO2009003125A1 (en) * | 2007-06-26 | 2008-12-31 | Warner Chilcott Company,Inc. | Intravaginal drug delivery devices for the delivery of macromolecules and water-soluble drugs |
US20110059040A1 (en) * | 2007-06-27 | 2011-03-10 | Kiser Patrick F | Compositions and methods for inhibiting viral and bacterial activity |
US8741329B2 (en) * | 2007-09-21 | 2014-06-03 | Merck Sharp & Dohme B.V. | Drug delivery system |
US8953685B2 (en) | 2007-12-10 | 2015-02-10 | Qualcomm Incorporated | Resource-adaptive video interpolation or extrapolation with motion level analysis |
US20110045076A1 (en) * | 2008-01-25 | 2011-02-24 | Kiser Patrick F | Linear order release polymer |
FI20085277A0 (fi) * | 2008-04-02 | 2008-04-02 | Bayer Schering Pharma Oy | Kohdunsisäinen järjestelmä |
US20110150955A1 (en) * | 2009-12-23 | 2011-06-23 | Shannon Elizabeth Klingman | Products and Methods for Reducing Malodor from the Pudendum |
-
2006
- 2006-07-08 GB GBGB0613638.6A patent/GB0613638D0/en not_active Ceased
-
2007
- 2007-06-27 PT PT07733405T patent/PT2038325E/pt unknown
- 2007-06-27 DE DE602007012545T patent/DE602007012545D1/de active Active
- 2007-06-27 PL PL07733405T patent/PL2038325T3/pl unknown
- 2007-06-27 BR BRPI0713481A patent/BRPI0713481B8/pt active IP Right Grant
- 2007-06-27 US US12/373,002 patent/US8361272B2/en active Active
- 2007-06-27 CN CN2007800256285A patent/CN101484495B/zh active Active
- 2007-06-27 WO PCT/GB2007/002415 patent/WO2008007046A1/en active Application Filing
- 2007-06-27 CA CA2656788A patent/CA2656788C/en active Active
- 2007-06-27 EP EP07733405A patent/EP2038325B1/en active Active
- 2007-06-27 JP JP2009517399A patent/JP5307710B2/ja active Active
- 2007-06-27 DK DK07733405.0T patent/DK2038325T3/da active
- 2007-06-27 AT AT07733405T patent/ATE498643T1/de active
- 2007-06-27 ES ES07733405T patent/ES2363704T3/es active Active
- 2007-06-27 AU AU2007274119A patent/AU2007274119B2/en active Active
-
2012
- 2012-09-06 US US13/605,689 patent/US8361273B2/en active Active
-
2013
- 2013-03-05 JP JP2013043282A patent/JP5639673B2/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08508314A (ja) * | 1993-04-01 | 1996-09-03 | ブリティッシュ・テクノロジー・グループ・リミテッド | ランダムブロツクコポリマー |
JPH0753663A (ja) * | 1993-07-30 | 1995-02-28 | Takiron Co Ltd | 経皮吸収製剤用基剤ポリマー |
JP2001501232A (ja) * | 1996-09-20 | 2001-01-30 | バイエル・アクチエンゲゼルシヤフト | 活性物質含有の熱可塑性ポリウレタン |
JP2002088571A (ja) * | 2000-09-11 | 2002-03-27 | Du Pont Toray Co Ltd | ポリウレタン繊維の製造方法 |
JP2005534732A (ja) * | 2002-06-14 | 2005-11-17 | ポリメーレクスペール エス アー | 熱感応性ポリマー及びそのポリマーから得られた熱可逆性ゲル |
JP2006500456A (ja) * | 2002-09-27 | 2006-01-05 | コントロールド・セラピューティクス(スコットランド)・リミテッド | 水膨潤性ポリマー |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013543763A (ja) * | 2010-11-12 | 2013-12-09 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデーション | 潤滑剤の制御送達のための膣内デバイス |
KR20140091647A (ko) * | 2010-11-12 | 2014-07-22 | 더 유니버시티 오브 유타 리서치 파운데이션 | 윤활제의 제어된 전달을 위한 질내 장치 |
US10350160B2 (en) | 2010-11-12 | 2019-07-16 | University Of Utah Research Foundation, The | Intravaginal devices for controlled delivery of lubricants |
KR101993786B1 (ko) * | 2010-11-12 | 2019-06-28 | 더 유니버시티 오브 유타 리서치 파운데이션 | 윤활제의 제어된 전달을 위한 질내 장치 |
US9642795B2 (en) | 2010-11-12 | 2017-05-09 | The University Of Utah Research Foundation | Intravaginal devices for controlled delivery of lubricants |
JP2014520896A (ja) * | 2011-07-20 | 2014-08-25 | エフ. カイザー,パトリック | 薬物送達のための膣内デバイス |
JPWO2013137290A1 (ja) * | 2012-03-13 | 2015-08-03 | 住友精化株式会社 | 化粧料組成物 |
KR20160097288A (ko) * | 2013-12-10 | 2016-08-17 | 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 | 고탄성 열가소성 폴리우레탄 |
KR102283445B1 (ko) * | 2013-12-10 | 2021-07-28 | 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 | 고탄성 열가소성 폴리우레탄 |
JP2022091999A (ja) * | 2014-04-01 | 2022-06-21 | ポリ-メッド インコーポレイテッド | 避妊具及び関連した器具 |
JP2017533272A (ja) * | 2014-11-07 | 2017-11-09 | フェリング ベスローテン フェンノートシャップ | キナゴリドを含有する薬物−デバイスユニット |
KR20170080671A (ko) * | 2014-11-07 | 2017-07-10 | 훼링 비.브이. | 퀴나골라이드를 포함하는 약물-디바이스 유닛 |
JP2021155444A (ja) * | 2014-11-07 | 2021-10-07 | フェリング ベスローテン フェンノートシャップ | キナゴリドを含有する薬物−デバイスユニット |
KR102612852B1 (ko) * | 2014-11-07 | 2023-12-11 | 훼링 비.브이. | 퀴나골라이드를 포함하는 약물-디바이스 유닛 |
WO2019111839A1 (ja) * | 2017-12-04 | 2019-06-13 | 住友精化株式会社 | 揮発性物質放散用組成物 |
JPWO2019111839A1 (ja) * | 2017-12-04 | 2021-01-07 | 住友精化株式会社 | 揮発性物質放散用組成物 |
CN111212883B (zh) * | 2017-12-04 | 2023-08-15 | 住友精化株式会社 | 挥发性物质发散用组合物 |
CN111212883A (zh) * | 2017-12-04 | 2020-05-29 | 住友精化株式会社 | 挥发性物质发散用组合物 |
Also Published As
Publication number | Publication date |
---|---|
AU2007274119B2 (en) | 2013-01-31 |
DE602007012545D1 (de) | 2011-03-31 |
CA2656788C (en) | 2015-01-27 |
ATE498643T1 (de) | 2011-03-15 |
BRPI0713481B1 (pt) | 2019-08-13 |
US20120329883A1 (en) | 2012-12-27 |
US20090324692A1 (en) | 2009-12-31 |
JP5639673B2 (ja) | 2014-12-10 |
US8361273B2 (en) | 2013-01-29 |
GB0613638D0 (en) | 2006-08-16 |
EP2038325B1 (en) | 2011-02-16 |
JP2013151517A (ja) | 2013-08-08 |
PL2038325T3 (pl) | 2011-07-29 |
WO2008007046A1 (en) | 2008-01-17 |
BRPI0713481B8 (pt) | 2021-05-25 |
PT2038325E (pt) | 2011-05-02 |
CN101484495B (zh) | 2011-12-28 |
DK2038325T3 (da) | 2011-05-30 |
CN101484495A (zh) | 2009-07-15 |
CA2656788A1 (en) | 2008-01-17 |
AU2007274119A1 (en) | 2008-01-17 |
JP5307710B2 (ja) | 2013-10-02 |
US8361272B2 (en) | 2013-01-29 |
EP2038325A1 (en) | 2009-03-25 |
ES2363704T3 (es) | 2011-08-12 |
BRPI0713481A2 (pt) | 2012-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5639673B2 (ja) | 放出制御組成物 | |
JP5394237B2 (ja) | 親水性ポリウレタン化合物 | |
JP4612419B2 (ja) | 水膨潤性ポリマー | |
AU2020270480A1 (en) | Drug-device unit containing quinagolide | |
EP2640354B1 (en) | Intravaginal drug delivery device comprising a polyurethane copolymer | |
AU2013205539B2 (en) | Polyurethane elastomers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100621 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100621 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20120402 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120802 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20121219 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20121225 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130305 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130402 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130419 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130618 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130627 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5307710 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |