|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
US20110313230A1
(en)
|
2001-05-11 |
2011-12-22 |
Terrance Grant Johns |
Specific binding proteins and uses thereof
|
|
DK1392359T4
(da)
|
2001-05-11 |
2013-06-10 |
Ludwig Inst For Cancer Res Ltd |
Specifikke bindingsproteiner og deres anvendelser.
|
|
HUE035853T2
(en)
*
|
2005-07-18 |
2018-05-28 |
Seattle Genetics Inc |
Beta-glucuronide-linker-drug conjugates
|
|
US7750116B1
(en)
*
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
PT2032606E
(pt)
|
2006-05-30 |
2014-02-05 |
Genentech Inc |
Anticorpos e imunoconjugados e respetivas utilizações
|
|
PT2845866T
(pt)
|
2006-10-27 |
2017-08-09 |
Genentech Inc |
Anticorpos e imunoconjugados e utilizações dos mesmos
|
|
US9090693B2
(en)
|
2007-01-25 |
2015-07-28 |
Dana-Farber Cancer Institute |
Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
|
|
JP5618549B2
(ja)
|
2007-03-15 |
2014-11-05 |
ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド |
Egfr抗体及びsrc阻害剤を用いる治療方法及び関連製剤
|
|
FR2914306B1
(fr)
*
|
2007-04-02 |
2009-07-03 |
Biocydex Soc Par Actions Simpl |
Oligomeres de cyclodextrines, vecteurs de molecules actives
|
|
PT2474557E
(pt)
|
2007-07-16 |
2014-12-03 |
Genentech Inc |
Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
|
|
PE20140625A1
(es)
|
2007-07-16 |
2014-05-29 |
Genentech Inc |
ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS
|
|
JP5532486B2
(ja)
|
2007-08-14 |
2014-06-25 |
ルードヴィッヒ インスティテュート フォー キャンサー リサーチ |
Egf受容体を標的とするモノクローナル抗体175ならびにその誘導体および用途
|
|
FR2920877B1
(fr)
*
|
2007-09-10 |
2010-01-22 |
Commissariat Energie Atomique |
Substrats fluorescents saccharidiques, leur procede de procede de preparation et leurs utisations.
|
|
KR101641345B1
(ko)
|
2007-10-12 |
2016-07-20 |
시애틀 지네틱스, 인크. |
항체-약물 접합체를 이용한 병용 요법
|
|
CN101903403B
(zh)
|
2007-10-19 |
2016-03-16 |
西雅图基因公司 |
Cd19结合剂及其应用
|
|
DK2657253T3
(en)
|
2008-01-31 |
2017-10-09 |
Genentech Inc |
Anti-CD79b antibodies and immune conjugates and methods of use
|
|
EP2240495B1
(en)
*
|
2008-02-01 |
2015-07-15 |
Genentech, Inc. |
Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
|
|
AU2009270988A1
(en)
*
|
2008-07-15 |
2010-01-21 |
Genentech, Inc. |
Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
|
|
EP2326350B1
(en)
|
2008-09-08 |
2013-09-04 |
Psma Development Company, L.L.C. |
Compounds for killing psma-expressing, taxane-resistant cancer cells
|
|
MA33256B1
(fr)
|
2009-04-01 |
2012-05-02 |
Genentech Inc |
Anticorps et immunoconjugués anti-fcrh5 et procédés d'utilisation
|
|
US20110076232A1
(en)
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
CN103068405A
(zh)
*
|
2010-04-15 |
2013-04-24 |
西雅图基因公司 |
靶向吡咯并苯并二氮杂卓结合物
|
|
NZ701208A
(en)
|
2010-06-03 |
2016-05-27 |
Genentech Inc |
Immuno-pet imaging of antibodies and immunoconjugates and uses thereof
|
|
EP2646456B1
(en)
|
2010-12-02 |
2015-01-21 |
Nerviano Medical Sciences S.r.l. |
Process for the preparation of morpholinyl anthracycline derivatives
|
|
JOP20210044A1
(ar)
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
|
WO2012094653A2
(en)
*
|
2011-01-07 |
2012-07-12 |
Massachusetts Institute Of Technology |
Compositions and methods for macromolecular drug delivery
|
|
EP2678037B1
(en)
|
2011-02-25 |
2014-12-03 |
Lonza Ltd |
Branched linker for protein drug conjugates
|
|
CN104906592B
(zh)
*
|
2011-02-25 |
2017-11-03 |
广州南沙龙沙有限公司 |
用于蛋白质药物偶联物的支链联接体
|
|
WO2012151039A2
(en)
*
|
2011-05-02 |
2012-11-08 |
The Regents Of The University Of California |
Compositions and methods for detecting mycobacterium
|
|
DK2707031T3
(da)
|
2011-05-08 |
2019-10-07 |
Legochem Biosciences Inc |
Protein-active agent conjugates and method for preparing the same
|
|
EP4286400A3
(en)
*
|
2011-05-18 |
2024-06-05 |
Eumederis Pharmaceuticals, Inc. |
Improved peptide pharmaceuticals
|
|
UA112434C2
(uk)
|
2011-05-27 |
2016-09-12 |
Ґлаксо Ґруп Лімітед |
Антигензв'язувальний білок, який специфічно зв'язується з всма
|
|
CN107043339B
(zh)
*
|
2011-07-19 |
2019-09-06 |
希默赛生物技术有限责任公司 |
新交联试剂、大分子、治疗用偶联物及其合成方法
|
|
ES2697674T3
(es)
|
2011-11-01 |
2019-01-25 |
Bionomics Inc |
Procedimientos para bloquear el crecimiento de células madre cancerosas
|
|
EP2592103A1
(en)
|
2011-11-08 |
2013-05-15 |
Adriacell S.p.A. |
Polymer aldehyde derivatives
|
|
AU2013216863B2
(en)
|
2012-02-10 |
2018-09-06 |
Seagen Inc. |
Detection and treatment of CD30+ cancers
|
|
CN104640572B
(zh)
|
2012-05-15 |
2018-04-27 |
索伦托医疗有限公司 |
药物偶联物,偶联方法,及其用途
|
|
US20150182490A1
(en)
|
2012-06-26 |
2015-07-02 |
Del Mar Pharmaceuticals |
Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
|
|
US10188693B2
(en)
|
2012-08-02 |
2019-01-29 |
Stealth Biotherapeutics Corp |
Methods for treatment of atherosclerosis
|
|
US9353150B2
(en)
|
2012-12-04 |
2016-05-31 |
Massachusetts Institute Of Technology |
Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
|
|
US8877202B2
(en)
*
|
2013-02-07 |
2014-11-04 |
Immunomedics, Inc. |
Pro-drug form (P2PDOX) of the highly potent 2-pyrrolinodoxorubicin conjugated to antibodies for targeted therapy of cancer
|
|
US9498540B2
(en)
|
2013-03-15 |
2016-11-22 |
Novartis Ag |
Cell proliferation inhibitors and conjugates thereof
|
|
HK1220626A1
(zh)
|
2013-03-15 |
2017-05-12 |
The Centre For Drug Research And Development |
具细胞毒性和抗有丝分裂的化合物以及其使用方法
|
|
TW201519904A
(zh)
|
2013-03-15 |
2015-06-01 |
Abbvie Inc |
抗體藥物結合物(adc)之純化
|
|
HK1219044A1
(zh)
|
2013-03-15 |
2017-03-24 |
艾伯维德国有限责任两合公司 |
抗egfr抗体药物偶联物制剂
|
|
CN105492011A
(zh)
|
2013-04-08 |
2016-04-13 |
丹尼斯·M·布朗 |
不理想给药化学化合物的治疗增效
|
|
DK2991683T3
(da)
|
2013-05-02 |
2019-11-04 |
Glykos Finland Oy |
Konjugater af et glykoprotein eller en glykan med en toksisk ladning
|
|
US10208125B2
(en)
|
2013-07-15 |
2019-02-19 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Anti-mucin 1 binding agents and uses thereof
|
|
CN105764526B
(zh)
|
2013-08-26 |
2020-12-15 |
生物技术研发公司 |
编码抗唾液酸化路易斯a抗原的人抗体的核酸
|
|
EP3049442A4
(en)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
PT3057585T
(pt)
*
|
2013-10-15 |
2020-10-21 |
Seagen Inc |
Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando
|
|
CN105813653B
(zh)
|
2013-12-19 |
2020-06-26 |
西雅图基因公司 |
与目标-药物偶联物并用的亚甲基氨基甲酸酯连接物
|
|
KR102384740B1
(ko)
|
2013-12-27 |
2022-04-07 |
자임워크스 인코포레이티드 |
약물 접합체를 위한 설폰아마이드-함유 연결 시스템
|
|
UA122479C2
(uk)
|
2014-01-24 |
2020-11-25 |
Дана-Фарбер Кенсер Інстітьют, Інк. |
Виділена молекула антитіла, яка зв’язується з людським білком програмованої смерті-1 (pd-1)
|
|
PL3099717T3
(pl)
|
2014-01-31 |
2019-10-31 |
Novartis Ag |
Cząsteczki przeciwciała dla TIM-3 i ich zastosowanie
|
|
FR3017298B1
(fr)
|
2014-02-07 |
2016-03-04 |
Centre Nat Rech Scient |
Conjugues et pro-drogues pour le traitement du cancer et de maladies inflammatoires
|
|
EA201691765A1
(ru)
|
2014-03-14 |
2016-12-30 |
Новартис Аг |
Молекулы антител против lag-3 и их применения
|
|
TWI731535B
(zh)
|
2014-03-21 |
2021-06-21 |
美商艾伯維有限公司 |
抗-egfr抗體及抗體藥物結合物
|
|
KR101628872B1
(ko)
|
2014-05-28 |
2016-06-09 |
주식회사 레고켐 바이오사이언스 |
자가-희생 기를 포함하는 화합물
|
|
US10576124B2
(en)
|
2014-05-28 |
2020-03-03 |
Stealth Biotherapeutics Corp |
Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
|
|
WO2015183988A1
(en)
|
2014-05-28 |
2015-12-03 |
Stealth Peptides International, Inc. |
Therapeutic compositions including therapeutic small molecules and uses thereof
|
|
US9856324B2
(en)
|
2014-06-04 |
2018-01-02 |
MabVax Therapeutics, Inc. |
Human monoclonal antibodies to ganglioside GD2
|
|
WO2015189477A1
(en)
|
2014-06-13 |
2015-12-17 |
Tenboron Oy |
Conjugates comprising an anti-egfr1 antibody
|
|
US10973920B2
(en)
|
2014-06-30 |
2021-04-13 |
Glykos Finland Oy |
Saccharide derivative of a toxic payload and antibody conjugates thereof
|
|
EP3191126B1
(en)
|
2014-09-13 |
2020-05-13 |
Novartis AG |
Combination therapies of alk inhibitors
|
|
ES2905569T3
(es)
|
2014-09-17 |
2022-04-11 |
Zymeworks Inc |
Compuestos citotóxicos y antimitóticos y métodos para utilizarlos
|
|
CA2966005C
(en)
|
2014-10-31 |
2021-04-27 |
Abbvie Biotherapeutics Inc. |
Anti-cs1 antibodies and antibody drug conjugates
|
|
US10077287B2
(en)
|
2014-11-10 |
2018-09-18 |
Bristol-Myers Squibb Company |
Tubulysin analogs and methods of making and use
|
|
RU2017123942A
(ru)
|
2014-12-09 |
2019-01-11 |
Эббви Инк. |
Ингибирующие bcl-xl соединения, обладающие низкой клеточной проницаемостью, и коньюгаты антитело-лекарственное средство, включающие их
|
|
EP3229844B1
(en)
|
2014-12-09 |
2020-03-04 |
AbbVie Inc. |
Antibody drug conjugates with cell permeable bcl-xl inhibitors
|
|
EP3229836B1
(en)
|
2014-12-09 |
2019-11-13 |
Institut National de la Sante et de la Recherche Medicale (INSERM) |
Human monoclonal antibodies against axl
|
|
CN107231804B
(zh)
|
2015-01-14 |
2019-11-26 |
百时美施贵宝公司 |
亚杂芳基桥连苯并二氮杂*二聚体、其缀合物及制备和使用方法
|
|
KR20170128256A
(ko)
*
|
2015-03-18 |
2017-11-22 |
시애틀 지네틱스, 인크. |
Cd48 항체 및 이의 접합체
|
|
US20180340025A1
(en)
|
2015-07-29 |
2018-11-29 |
Novartis Ag |
Combination therapies comprising antibody molecules to lag-3
|
|
WO2017051249A1
(en)
*
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-cd19 antibody drug conjugates
|
|
WO2017051254A1
(en)
*
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-egfr antibody drug conjugates
|
|
CN108699095B
(zh)
*
|
2015-10-07 |
2022-05-13 |
伊利诺伊大学评议会 |
用于癌症选择性标记和靶向的触发子可活化代谢糖前体
|
|
WO2017060397A1
(en)
|
2015-10-09 |
2017-04-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the survival time of subjects suffering from melanoma metastases
|
|
WO2017067944A1
(en)
|
2015-10-19 |
2017-04-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for predicting the survival time of subjects suffering from triple negative breast cancer
|
|
TWI660741B
(zh)
|
2015-11-03 |
2019-06-01 |
財團法人工業技術研究院 |
抗體藥物複合物及其製造方法
|
|
HUE067016T2
(hu)
|
2015-11-25 |
2024-09-28 |
Ligachem Biosciences Inc |
Önfeláldozó csoportokat tartalmazó konjugátumok és ezekkel kapcsolos eljárások
|
|
JP7120765B2
(ja)
*
|
2015-11-25 |
2022-08-17 |
レゴケム バイオサイエンシズ, インク. |
ペプチド基を含む複合体及びそれに関連する方法
|
|
CN107847605B
(zh)
|
2015-11-25 |
2021-12-24 |
乐高化学生物科学股份有限公司 |
包含分支接头的抗体-药物缀合物及其相关方法
|
|
EP3383909B1
(en)
|
2015-11-30 |
2020-06-17 |
AbbVie Inc. |
Anti-human lrrc15 antibody drug conjugates and methods for their use
|
|
JP2019501124A
(ja)
|
2015-11-30 |
2019-01-17 |
アッヴィ・インコーポレイテッド |
抗huLRRC15抗体薬物コンジュゲート及びその使用方法
|
|
US11229708B2
(en)
|
2015-12-04 |
2022-01-25 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
US11793880B2
(en)
|
2015-12-04 |
2023-10-24 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
CN108495651A
(zh)
|
2015-12-17 |
2018-09-04 |
诺华股份有限公司 |
抗pd-1的抗体分子及其用途
|
|
TWI719105B
(zh)
*
|
2016-01-04 |
2021-02-21 |
中央硏究院 |
基於酯化/皂化用於微脂體負載之方法
|
|
KR102438140B1
(ko)
|
2016-03-22 |
2022-08-31 |
엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔 |
인간화 항-클라우딘-1 항체 및 이의 용도
|
|
US10745487B2
(en)
|
2016-03-22 |
2020-08-18 |
Bionomics Limited |
Method of treating cancer by administering an anti-LGR5 monoclonal antibody
|
|
EP3433278A4
(en)
*
|
2016-03-25 |
2019-11-06 |
Seattle Genetics, Inc. |
METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF
|
|
US10918627B2
(en)
|
2016-05-11 |
2021-02-16 |
Massachusetts Institute Of Technology |
Convergent and enantioselective total synthesis of Communesin analogs
|
|
RS61659B1
(sr)
|
2016-05-17 |
2021-04-29 |
Abbvie Biotherapeutics Inc |
Konjugati antitelo lek anti-cmet i metode za njihovu upotrebu
|
|
MX2018015284A
(es)
|
2016-06-08 |
2019-09-18 |
Abbvie Inc |
Conjugados de anticuerpo anti-egfr y fármaco.
|
|
RS61828B1
(sr)
|
2016-06-08 |
2021-06-30 |
Abbvie Inc |
Anti-b7-h3 antitela i antitelske konjugacije lekova
|
|
WO2017214456A1
(en)
|
2016-06-08 |
2017-12-14 |
Abbvie Inc. |
Anti-cd98 antibodies and antibody drug conjugates
|
|
MX2018015268A
(es)
|
2016-06-08 |
2019-08-12 |
Abbvie Inc |
Anticuerpos anti-cd98 y conjugados de anticuerpo y farmaco.
|
|
MX2018015272A
(es)
|
2016-06-08 |
2019-08-12 |
Abbvie Inc |
Anticuerpos anti-cd98 y conjugados de anticuerpo y farmaco.
|
|
JP2019526529A
(ja)
|
2016-06-08 |
2019-09-19 |
アッヴィ・インコーポレイテッド |
抗b7−h3抗体及び抗体薬物コンジュゲート
|
|
CN109562190A
(zh)
|
2016-06-08 |
2019-04-02 |
艾伯维公司 |
抗egfr抗体药物偶联物
|
|
CN116059201A
(zh)
|
2016-06-08 |
2023-05-05 |
艾伯维公司 |
抗egfr抗体药物偶联物
|
|
CN109641962A
(zh)
|
2016-06-08 |
2019-04-16 |
艾伯维公司 |
抗b7-h3抗体和抗体药物偶联物
|
|
JP2018058822A
(ja)
|
2016-08-03 |
2018-04-12 |
ファイザー・インク |
ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用
|
|
KR20240010534A
(ko)
|
2016-08-09 |
2024-01-23 |
씨젠 인크. |
개선된 물리화학적 특성을 갖는 자기 안정화 링커를 구비한 약물 접합체
|
|
WO2018035391A1
(en)
|
2016-08-19 |
2018-02-22 |
Bristol-Myers Squibb Company |
Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
|
|
US10398783B2
(en)
|
2016-10-20 |
2019-09-03 |
Bristol-Myers Squibb Company |
Antiproliferative compounds and conjugates made therefrom
|
|
CN110121508A
(zh)
|
2016-10-25 |
2019-08-13 |
法国国家健康和医学研究院 |
与cd160跨膜同种型结合的单克隆抗体
|
|
CN109996543A
(zh)
*
|
2016-11-14 |
2019-07-09 |
醣基生医股份有限公司 |
抗体药物复合体
|
|
MA46759A
(fr)
*
|
2016-11-14 |
2019-09-18 |
Millennium Pharm Inc |
Dosage de conjugués anticorps-médicament anti-cd30 pour humain non adulte
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
DK3544634T3
(da)
*
|
2016-11-23 |
2021-06-07 |
Lilly Co Eli |
MET-antistof-lægemiddelkonjugater
|
|
JP7244987B2
(ja)
|
2016-12-14 |
2023-03-23 |
シージェン インコーポレイテッド |
多剤抗体薬物コンジュゲート
|
|
EP3554544A4
(en)
|
2016-12-16 |
2020-07-29 |
Bluefin Biomedicine, Inc. |
ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
|
|
KR102085798B1
(ko)
|
2016-12-28 |
2020-03-06 |
주식회사 인투셀 |
베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물
|
|
EP3573995A1
(en)
|
2017-01-24 |
2019-12-04 |
Pfizer Inc. |
Calicheamicin derivatives and antibody drug conjugates thereof
|
|
EP3579872A1
(en)
|
2017-02-10 |
2019-12-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
|
|
US11299509B2
(en)
|
2017-02-10 |
2022-04-12 |
The Board Of Trustees Of The University Of Illinois |
Trigger-activatable sugar conjugates for cancer-selective labeling and targeting
|
|
JP7527787B2
(ja)
|
2017-03-24 |
2024-08-05 |
シージェン インコーポレイテッド |
グルクロニド薬物-リンカーの調製のためのプロセスおよびその中間体
|
|
JP7664680B2
(ja)
|
2017-03-29 |
2025-04-18 |
リガケム バイオサイエンシズ, インク. |
ピロロベンゾジアゼピン二量体前駆体及びそのリガンド-リンカーコンジュゲート化合物
|
|
US11932650B2
(en)
|
2017-05-11 |
2024-03-19 |
Massachusetts Institute Of Technology |
Potent agelastatin derivatives as modulators for cancer invasion and metastasis
|
|
US11666657B2
(en)
|
2017-05-16 |
2023-06-06 |
Universite De Strasbourg |
Protein-drug conjugates and their use in the treatment of cancers
|
|
WO2018234843A1
(en)
|
2017-06-22 |
2018-12-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FIBROSIS WITH AGENTS CAPABLE OF INHIBITING THE ACTIVATION OF MOSES-ASSOCIATED INVARIANT T CELLS (MAIT)
|
|
US10494370B2
(en)
|
2017-08-16 |
2019-12-03 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
|
|
US10472361B2
(en)
|
2017-08-16 |
2019-11-12 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
|
|
US10487084B2
(en)
|
2017-08-16 |
2019-11-26 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
|
|
US10457681B2
(en)
|
2017-08-16 |
2019-10-29 |
Bristol_Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
|
|
US10508115B2
(en)
|
2017-08-16 |
2019-12-17 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
|
|
WO2019051488A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
US11707531B2
(en)
|
2017-09-11 |
2023-07-25 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US11707522B2
(en)
|
2017-10-13 |
2023-07-25 |
Boehringer Ingelheim International Gmbh |
Human antibodies to Tn antigen
|
|
US10640508B2
(en)
|
2017-10-13 |
2020-05-05 |
Massachusetts Institute Of Technology |
Diazene directed modular synthesis of compounds with quaternary carbon centers
|
|
EP3498293A1
(en)
|
2017-12-15 |
2019-06-19 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Treatment of monogenic diseases with an anti-cd45rc antibody
|
|
WO2019183131A1
(en)
|
2018-03-19 |
2019-09-26 |
Bioventures, Llc |
Periostin antibodies and methods of using the same
|
|
WO2019209811A1
(en)
|
2018-04-24 |
2019-10-31 |
Bristol-Myers Squibb Company |
Macrocyclic toll-like receptor 7 (tlr7) agonists
|
|
EA202092136A1
(ru)
|
2018-05-07 |
2021-03-22 |
Генмаб А/С |
Способы лечения рака с помощью комбинации антитела к pd-1 и конъюгата антитела к тканевому фактору и лекарственного средства
|
|
JP7460608B2
(ja)
|
2018-05-07 |
2024-04-02 |
ジェンマブ エー/エス |
抗pd-1抗体と抗組織因子抗体-薬物コンジュゲートとの組み合わせを用いるがんの治療方法
|
|
US11827703B2
(en)
|
2018-05-09 |
2023-11-28 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-CD19 antibody drug conjugates
|
|
JP7458997B2
(ja)
|
2018-05-29 |
2024-04-01 |
ブリストル-マイヤーズ スクイブ カンパニー |
プロドラッグおよび複合体に使用する修飾自己切断部分ならびにその使用方法および製造方法
|
|
PE20210320A1
(es)
|
2018-06-01 |
2021-02-16 |
Novartis Ag |
Moleculas de union contra bcma y usos de las mismas
|
|
AU2019301697A1
(en)
*
|
2018-07-13 |
2021-01-07 |
Il-2Rx, Inc. |
Compounds, compositions, methods, and uses for treating cancer and immunological disorders
|
|
JP2020019723A
(ja)
*
|
2018-07-30 |
2020-02-06 |
国立大学法人 鹿児島大学 |
抗CD70抗体とIgG結合ペプチドの複合体
|
|
US11554120B2
(en)
|
2018-08-03 |
2023-01-17 |
Bristol-Myers Squibb Company |
1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
|
|
WO2020058372A1
(en)
|
2018-09-19 |
2020-03-26 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the treatment of cancers resistant to immune checkpoint therapy
|
|
EP3626265A1
(en)
|
2018-09-21 |
2020-03-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Anti-human cd45rc antibodies and uses thereof
|
|
GB201817321D0
(en)
|
2018-10-24 |
2018-12-05 |
Nanna Therapeutics Ltd |
Microbeads for tagless encoded chemical library screening
|
|
TWI844571B
(zh)
|
2018-10-30 |
2024-06-11 |
丹麥商珍美寶股份有限公司 |
使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法
|
|
US20220025058A1
(en)
|
2018-11-06 |
2022-01-27 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of acute myeloid leukemia by eradicating leukemic stem cells
|
|
KR20210099614A
(ko)
|
2018-12-04 |
2021-08-12 |
노파르티스 아게 |
Cd3에 대한 결합 분자 및 이의 용도
|
|
EP3894543A1
(en)
|
2018-12-14 |
2021-10-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Isolated mhc-derived human peptides and uses thereof for stimulating and activating the suppressive function of cd8cd45rc low tregs
|
|
JP7754715B2
(ja)
|
2019-02-05 |
2025-10-15 |
シージェン インコーポレイテッド |
抗cd228抗体及び抗体薬物コンジュゲート
|
|
CA3133155A1
(en)
|
2019-03-19 |
2020-09-24 |
Fundacio Privada Institut D'investigacio Oncologica De Vall Hebron |
Combination therapy for the treatment for cancer
|
|
US12037378B2
(en)
|
2019-05-21 |
2024-07-16 |
Novartis Ag |
Variant CD58 domains and uses thereof
|
|
UY38701A
(es)
|
2019-05-21 |
2020-12-31 |
Novartis Ag |
Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas
|
|
WO2020247054A1
(en)
|
2019-06-05 |
2020-12-10 |
Massachusetts Institute Of Technology |
Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
|
|
CN114585651A
(zh)
|
2019-08-08 |
2022-06-03 |
再生元制药公司 |
新型抗原结合分子形式
|
|
CN114127121B
(zh)
|
2019-08-12 |
2025-04-11 |
北京恩瑞尼生物科技股份有限公司 |
用于通过cd39表达细胞的adcc靶向促进和增强t细胞介导的免疫反应的方法和组合物
|
|
WO2021046139A1
(en)
*
|
2019-09-04 |
2021-03-11 |
Seagen Inc. |
Double-digestion assay for analyzing ligand-drug conjugates
|
|
KR20210028544A
(ko)
|
2019-09-04 |
2021-03-12 |
주식회사 레고켐 바이오사이언스 |
인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
|
|
AU2020348876A1
(en)
|
2019-09-19 |
2022-04-07 |
Seagen Inc. |
Selective drug release from internalized conjugates of biologically active compounds
|
|
US20220363776A1
(en)
|
2019-10-04 |
2022-11-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the treatment of ovarian cancer, breast cancer or pancreatic cancer
|
|
US20210324031A1
(en)
*
|
2019-10-16 |
2021-10-21 |
Clarence Hurt |
Compounds, compositions, methods, and uses for treating leptin resistance, obesity, diabetes mellitus and metabolic syndrome
|
|
US12435116B2
(en)
*
|
2019-10-16 |
2025-10-07 |
Clarence Hurt |
Compounds, compositions, methods, and uses for treating insulin resistance, type 2 diabetes and metabolic syndrome
|
|
AU2020379735A1
(en)
|
2019-11-05 |
2022-05-26 |
Regeneron Pharmaceuticals, Inc. |
N-terminal SCFV multispecific binding molecules
|
|
WO2021090272A1
(en)
|
2019-11-07 |
2021-05-14 |
Genmab A/S |
Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate
|
|
TW202131954A
(zh)
|
2019-11-07 |
2021-09-01 |
丹麥商珍美寶股份有限公司 |
利用鉑類劑與抗組織因子抗體-藥物共軛體之組合來治療癌症之方法
|
|
EP4054561A4
(en)
|
2019-11-08 |
2023-12-20 |
North Carolina State University |
Cross-linking compounds and methods of use thereof
|
|
TWI877278B
(zh)
|
2019-12-30 |
2025-03-21 |
美商思進公司 |
以非海藻糖苷化抗-cd70抗體治療癌症之方法
|
|
JP7859981B2
(ja)
|
2020-03-06 |
2026-05-15 |
ジーオー セラピューティクス,インコーポレイテッド |
抗グリコcd44抗体およびその使用
|
|
WO2021195513A1
(en)
|
2020-03-27 |
2021-09-30 |
Novartis Ag |
Bispecific combination therapy for treating proliferative diseases and autoimmune disorders
|
|
AU2021251875A1
(en)
|
2020-04-10 |
2022-11-03 |
Seagen Inc. |
Charge variant linkers
|
|
AU2021275489A1
(en)
|
2020-05-20 |
2022-12-01 |
Centre National De La Recherche Scientifique - Cnrs - |
Single domain antibodies and their use in cancer therapies
|
|
KR20230028492A
(ko)
|
2020-06-29 |
2023-02-28 |
젠맵 에이/에스 |
항-조직 인자 항체-약물 접합체 및 암의 치료에서의 그의 용도
|
|
EP4189071A1
(en)
|
2020-08-03 |
2023-06-07 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Population of treg cells functionally committed to exert a regulatory activity and their use for adoptive therapy
|
|
CN112062855B
(zh)
|
2020-08-26 |
2024-08-30 |
北京天诺健成医药科技有限公司 |
一种含有衔接器的药物治疗剂的开发和应用
|
|
WO2022079270A1
(en)
|
2020-10-16 |
2022-04-21 |
Université D'aix-Marseille |
Anti-gpc4 single domain antibodies
|
|
CN118878693A
(zh)
|
2020-11-23 |
2024-11-01 |
康诺亚生物医药科技(成都)有限公司 |
一种双特异性抗体及其用途
|
|
CN114685657B
(zh)
|
2020-12-31 |
2024-08-16 |
康诺亚生物医药科技(成都)有限公司 |
一种功能增强型抗体阻断剂的开发及其应用
|
|
EP4277934A1
(en)
|
2021-01-14 |
2023-11-22 |
Institut Curie |
Her2 single domain antibodies variants and cars thereof
|
|
EP4277904A1
(en)
|
2021-01-15 |
2023-11-22 |
Seagen Inc. |
Immunomodulatory antibody-drug conjugates
|
|
CN117062527A
(zh)
|
2021-01-19 |
2023-11-14 |
埃里莫斯制药有限责任公司 |
作为冠状病毒抗病毒剂的Terameprocol和去甲二氢愈创木酸(NDGA)衍生物
|
|
AR124681A1
(es)
|
2021-01-20 |
2023-04-26 |
Abbvie Inc |
Conjugados anticuerpo-fármaco anti-egfr
|
|
MX2023009113A
(es)
|
2021-02-03 |
2023-08-10 |
Seagen Inc |
Conjugados y compuestos inmunoestimulantes.
|
|
WO2022182415A1
(en)
|
2021-02-24 |
2022-09-01 |
Massachusetts Institute Of Technology |
Himastatin derivatives, and processes of preparation thereof, and uses thereof
|
|
EP4301782A1
(en)
|
2021-03-05 |
2024-01-10 |
Go Therapeutics, Inc. |
Anti-glyco-cd44 antibodies and their uses
|
|
IL305886A
(en)
|
2021-03-18 |
2023-11-01 |
Seagen Inc |
Selective release of drugs from internalized conjugates of biologically active compounds
|
|
JP2024510435A
(ja)
|
2021-03-18 |
2024-03-07 |
シージェン インコーポレイテッド |
生体活性化合物の内部移行複合体からの選択的薬物放出
|
|
KR20240012352A
(ko)
|
2021-03-23 |
2024-01-29 |
인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) |
T 세포 림프종의 진단 및 치료 방법
|
|
EP4320153A1
(en)
|
2021-04-09 |
2024-02-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of anaplastic large cell lymphoma
|
|
IL308795A
(en)
|
2021-05-28 |
2024-01-01 |
Seagen Inc |
Anthracycline antibody conjugates
|
|
JP2024531915A
(ja)
|
2021-08-05 |
2024-09-03 |
ジーオー セラピューティクス,インコーポレイテッド |
抗グリコmuc抗体およびその使用
|
|
JP2024534910A
(ja)
|
2021-09-03 |
2024-09-26 |
ジーオー セラピューティクス,インコーポレイテッド |
抗グリコlamp1抗体およびその使用
|
|
WO2023034569A1
(en)
|
2021-09-03 |
2023-03-09 |
Go Therapeutics, Inc. |
Anti-glyco-cmet antibodies and their uses
|
|
PL4401842T3
(pl)
|
2021-09-16 |
2025-11-24 |
Aboleris Pharma |
Domeny wiążące przeciwko ludzkiemu CD45RC i ich zastosowania
|
|
WO2023110937A1
(en)
|
2021-12-14 |
2023-06-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Depletion of nk cells for the treatment of adverse post-ischemic cardiac remodeling
|
|
WO2023144303A1
(en)
|
2022-01-31 |
2023-08-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Cd38 as a biomarker and biotarget in t-cell lymphomas
|
|
WO2023198648A1
(en)
|
2022-04-11 |
2023-10-19 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the diagnosis and treatment of t-cell malignancies
|
|
WO2023198874A1
(en)
|
2022-04-15 |
2023-10-19 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the diagnosis and treatment of t cell-lymphomas
|
|
EP4518905A1
(en)
|
2022-05-06 |
2025-03-12 |
Seagen Inc. |
Immunomodulatory antibody-drug conjugates
|
|
JP2025515166A
(ja)
|
2022-05-06 |
2025-05-13 |
ジェンマブ エー/エス |
抗組織因子抗体-薬物コンジュゲートを用いたがんの治療方法
|
|
WO2023231877A1
(zh)
*
|
2022-05-31 |
2023-12-07 |
山东博安生物技术股份有限公司 |
抗cd228抗体及其药物偶联物
|
|
EP4545096A1
(en)
|
2022-06-27 |
2025-04-30 |
Trioar, Inc. |
Compound comprising self-immolative group and ligand-drug conjugate comprising same
|
|
IL318450A
(en)
|
2022-08-03 |
2025-03-01 |
Seagen Inc |
Immunostimulatory ANTI-PD-L1-Drug conjugates
|
|
CN119997982A
(zh)
|
2022-09-09 |
2025-05-13 |
迈里克斯制药有限公司 |
包含nmt抑制剂的抗体药物偶联物及其用途
|
|
WO2024089013A1
(en)
|
2022-10-25 |
2024-05-02 |
Peptomyc, S.L. |
Combination therapy for the treatment of cancer
|
|
AU2023371764A1
(en)
|
2022-11-01 |
2025-05-15 |
AbTis Co., Ltd. |
Compound comprising fc-binding unit, and conjugate prepared using same
|
|
AU2023396827A1
(en)
|
2022-12-13 |
2025-06-19 |
Crinetics Pharmaceuticals, Inc. |
Somatostatin subtype-2 receptor (sst2r) targeted therapeutics and uses thereof
|
|
CN121002062A
(zh)
|
2023-01-13 |
2025-11-21 |
再生元制药公司 |
Fgfr3结合分子及其使用方法
|
|
AU2024213541A1
(en)
*
|
2023-01-30 |
2025-08-07 |
Primelink Biotherapeutics (Shenzhen) Co., Ltd. |
Polymer-drug conjugates
|
|
WO2024166056A1
(en)
*
|
2023-02-10 |
2024-08-15 |
Pinotbio, Inc. |
Linker for antibody-drug conjugate
|
|
WO2024189048A1
(en)
|
2023-03-13 |
2024-09-19 |
Heidelberg Pharma Research Gmbh |
Subcutaneously administered antibody-drug conjugates for use in cancer treatment
|
|
AU2024238898A1
(en)
|
2023-03-22 |
2025-10-16 |
Salubris Biotherapeutics, Inc. |
Anti-5t4 antigen binding domains, antibody-drug conjugates and methods of use thereof
|
|
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