JP2014502957A5 - - Google Patents
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- JP2014502957A5 JP2014502957A5 JP2013535097A JP2013535097A JP2014502957A5 JP 2014502957 A5 JP2014502957 A5 JP 2014502957A5 JP 2013535097 A JP2013535097 A JP 2013535097A JP 2013535097 A JP2013535097 A JP 2013535097A JP 2014502957 A5 JP2014502957 A5 JP 2014502957A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- antibody
- inhibitor
- auristatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40576710P | 2010-10-22 | 2010-10-22 | |
| US61/405,767 | 2010-10-22 | ||
| US201161445785P | 2011-02-23 | 2011-02-23 | |
| US61/445,785 | 2011-02-23 | ||
| PCT/US2011/057130 WO2012054748A2 (en) | 2010-10-22 | 2011-10-20 | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016252182A Division JP6467400B2 (ja) | 2010-10-22 | 2016-12-27 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502957A JP2014502957A (ja) | 2014-02-06 |
| JP2014502957A5 true JP2014502957A5 (enExample) | 2014-12-04 |
| JP6121906B2 JP6121906B2 (ja) | 2017-04-26 |
Family
ID=45975893
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535097A Active JP6121906B2 (ja) | 2010-10-22 | 2011-10-20 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴｍＴＯＲ経路インヒビターの間の相乗効果 |
| JP2016252182A Active JP6467400B2 (ja) | 2010-10-22 | 2016-12-27 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
| JP2019003384A Pending JP2019070021A (ja) | 2010-10-22 | 2019-01-11 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016252182A Active JP6467400B2 (ja) | 2010-10-22 | 2016-12-27 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
| JP2019003384A Pending JP2019070021A (ja) | 2010-10-22 | 2019-01-11 | アウリスタチン系抗体薬物複合体とＰＩ３Ｋ−ＡＫＴ ｍＴＯＲ経路インヒビターの間の相乗効果 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9272052B2 (enExample) |
| EP (2) | EP2629801B3 (enExample) |
| JP (3) | JP6121906B2 (enExample) |
| CN (2) | CN103561759B (enExample) |
| AU (1) | AU2011316917B2 (enExample) |
| CA (1) | CA2815363C (enExample) |
| ES (2) | ES3004351T3 (enExample) |
| TW (1) | TWI545134B (enExample) |
| WO (1) | WO2012054748A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9272052B2 (en) | 2010-10-22 | 2016-03-01 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the PI3K-AKT mTOR pathway |
| BR112013031819B1 (pt) | 2011-06-10 | 2022-05-03 | Mersana Therapeutics, Inc | Suporte polimérico, composição farmacêutica, composto, e, uso do suporte |
| AU2013256336B2 (en) | 2012-05-01 | 2018-02-01 | The Children's Hospital Of Philadelphia | Compositions and methods for treating B-lymphoid malignancies |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| KR102557309B1 (ko) * | 2012-05-15 | 2023-07-20 | 씨젠 인크. | 자가-안정화 링커 접합체 |
| WO2014058947A1 (en) * | 2012-10-12 | 2014-04-17 | Sanofi | Compositions and methods for treating cancer using pi3k inhibitor and anti-cd19 maytansinoid immunoconjugate |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| KR20160055253A (ko) | 2013-09-12 | 2016-05-17 | 할로자임, 아이엔씨 | 변형된 항-상피세포 성장인자 수용체 항체 및 이의 사용 방법 |
| PL3082877T3 (pl) | 2013-12-17 | 2020-02-28 | Novartis Ag | Cytotoksyczne peptydy i ich koniugaty |
| JP2017512814A (ja) * | 2014-04-07 | 2017-05-25 | シアトル ジェネティックス， インコーポレイテッド | 抗ｃｄ１９抗体および抗体−薬物結合体のための安定な製剤 |
| WO2015157297A1 (en) * | 2014-04-08 | 2015-10-15 | Seattle Genetics, Inc. | Optimal dosing of a cd19-antibody drug conjugate |
| EP2930188A1 (en) * | 2014-04-13 | 2015-10-14 | Affimed Therapeutics AG | Trifunctional antigen-binding molecule |
| KR101795984B1 (ko) * | 2014-04-25 | 2017-11-10 | 피에르 파브르 메디카먼트 | Igf-1r 항체-약물-결합체 및 암의 치료를 위한 그의 용도 |
| EP3134125B1 (en) * | 2014-04-25 | 2019-10-09 | Pierre Fabre Medicament | Antibody-drug-conjugate and its use for the treatment of cancer |
| KR20170016479A (ko) | 2014-06-13 | 2017-02-13 | 노파르티스 아게 | 아우리스타틴 유도체 및 그의 접합체 |
| WO2016001485A1 (en) | 2014-06-30 | 2016-01-07 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| MX2017004580A (es) * | 2014-10-10 | 2017-06-27 | Pfizer | Combinaciones de auristatina sinergica. |
| WO2017019489A1 (en) * | 2015-07-24 | 2017-02-02 | George Robert Pettit | Quinstatin compounds |
| EP3954388A1 (en) * | 2015-08-21 | 2022-02-16 | MorphoSys AG | Combinations and uses thereof |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
| MA45862A (fr) * | 2016-08-04 | 2021-05-05 | Millennium Pharm Inc | Combinaison d'inhibiteurs du protéasome et d'anticorps anti-cd30 |
| EP3496747A4 (en) | 2016-08-09 | 2020-04-15 | Seattle Genetics, Inc. | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
| CN110234348B (zh) | 2016-12-16 | 2024-06-25 | 蓝鳍生物医药公司 | 抗-含cub结构域蛋白1(cdcp1)抗体、抗体药物缀合物及其使用方法 |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US11434303B2 (en) | 2017-06-28 | 2022-09-06 | Bluefin Biomedicine, Inc. | Anti-LY6H antibodies and antibody drug conjugates |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| WO2019088176A1 (ja) * | 2017-10-31 | 2019-05-09 | 国立大学法人神戸大学 | 抗体薬物複合体効果増強剤 |
| US11672827B2 (en) | 2017-12-23 | 2023-06-13 | Uwell Biopharma Inc. | Pharmaceutical chimeric receptor composition and method thereof |
| BR112020018948A2 (pt) * | 2018-03-23 | 2021-01-05 | Seattle Genetics, Inc. | Uso de conjugados de fármaco e anticorpo que compreendem agentes de interrupção de tubulina para tratar tumor sólido |
| JP2020019723A (ja) * | 2018-07-30 | 2020-02-06 | 国立大学法人 鹿児島大学 | 抗ＣＤ７０抗体とＩｇＧ結合ペプチドの複合体 |
| WO2020088164A1 (zh) * | 2018-11-01 | 2020-05-07 | 山东新时代药业有限公司 | 双特异性抗体及其用途 |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| CN119143877A (zh) * | 2020-03-03 | 2024-12-17 | 成都百利多特生物药业有限责任公司 | 抗cd19抗体及其使用和制备方法 |
| WO2022122889A1 (en) * | 2020-12-10 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for detecting the activation of mtor pathway |
| US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| WO2022198231A1 (en) * | 2021-03-18 | 2022-09-22 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| EP4634226A1 (en) | 2022-12-16 | 2025-10-22 | Pheon Therapeutics Ltd | Antibodies to cub domain-containing protein 1 (cdcp1) and uses thereof |
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| EP2376110B1 (en) * | 2009-01-09 | 2019-03-13 | Seattle Genetics, Inc. | Weekly dosing regimens for anti-cd30 vc-pab-mmae antibody drug-conjugates |
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-
2011
- 2011-10-20 US US13/879,012 patent/US9272052B2/en active Active
- 2011-10-20 AU AU2011316917A patent/AU2011316917B2/en active Active
- 2011-10-20 EP EP11835158.4A patent/EP2629801B3/en active Active
- 2011-10-20 ES ES19173675T patent/ES3004351T3/es active Active
- 2011-10-20 ES ES11835158T patent/ES2730941T7/es active Active
- 2011-10-20 CA CA2815363A patent/CA2815363C/en active Active
- 2011-10-20 CN CN201180051054.5A patent/CN103561759B/zh active Active
- 2011-10-20 JP JP2013535097A patent/JP6121906B2/ja active Active
- 2011-10-20 TW TW100138137A patent/TWI545134B/zh active
- 2011-10-20 WO PCT/US2011/057130 patent/WO2012054748A2/en not_active Ceased
- 2011-10-20 CN CN201610826795.0A patent/CN106563128B/zh active Active
- 2011-10-20 EP EP19173675.0A patent/EP3581206B8/en active Active
-
2016
- 2016-01-27 US US15/008,365 patent/US10201615B2/en active Active
- 2016-12-27 JP JP2016252182A patent/JP6467400B2/ja active Active
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2018
- 2018-12-19 US US16/226,509 patent/US11607460B2/en active Active
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2019
- 2019-01-11 JP JP2019003384A patent/JP2019070021A/ja active Pending
-
2023
- 2023-02-09 US US18/166,491 patent/US12496353B2/en active Active
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