JP2017515802A5 - - Google Patents
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- JP2017515802A5 JP2017515802A5 JP2016561626A JP2016561626A JP2017515802A5 JP 2017515802 A5 JP2017515802 A5 JP 2017515802A5 JP 2016561626 A JP2016561626 A JP 2016561626A JP 2016561626 A JP2016561626 A JP 2016561626A JP 2017515802 A5 JP2017515802 A5 JP 2017515802A5
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- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- halo
- cancer
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461976880P | 2014-04-08 | 2014-04-08 | |
| US61/976,880 | 2014-04-08 | ||
| US201462019577P | 2014-07-01 | 2014-07-01 | |
| US62/019,577 | 2014-07-01 | ||
| PCT/US2015/024146 WO2015157093A1 (en) | 2014-04-08 | 2015-04-02 | 2,3-disubstituted pyridine compounds as tgf-beta inhibitors and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019134857A Division JP2019196387A (ja) | 2014-04-08 | 2019-07-22 | Ｔｇｆ−ベータ阻害剤としての２，３−二置換ピリジン化合物および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515802A JP2017515802A (ja) | 2017-06-15 |
| JP2017515802A5 true JP2017515802A5 (enExample) | 2018-05-24 |
| JP6767875B2 JP6767875B2 (ja) | 2020-10-14 |
Family
ID=52875332
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016561626A Expired - Fee Related JP6767875B2 (ja) | 2014-04-08 | 2015-04-02 | Ｔｇｆ−ベータ阻害剤としての２，３−二置換ピリジン化合物および使用方法 |
| JP2019134857A Withdrawn JP2019196387A (ja) | 2014-04-08 | 2019-07-22 | Ｔｇｆ−ベータ阻害剤としての２，３−二置換ピリジン化合物および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019134857A Withdrawn JP2019196387A (ja) | 2014-04-08 | 2019-07-22 | Ｔｇｆ−ベータ阻害剤としての２，３−二置換ピリジン化合物および使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10233170B2 (enExample) |
| EP (1) | EP3129367B1 (enExample) |
| JP (2) | JP6767875B2 (enExample) |
| CN (1) | CN106536507B (enExample) |
| ES (1) | ES2759240T3 (enExample) |
| TW (1) | TW201623279A (enExample) |
| UY (1) | UY36068A (enExample) |
| WO (1) | WO2015157093A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015157093A1 (en) * | 2014-04-08 | 2015-10-15 | Rigel Pharmaceuticals, Inc. | 2,3-disubstituted pyridine compounds as tgf-beta inhibitors and methods of use |
| CN107531666A (zh) * | 2015-02-20 | 2018-01-02 | 里格尔药品股份有限公司 | Gdf‑8抑制剂 |
| BR112018003588A2 (pt) | 2015-08-26 | 2018-09-25 | Blueprint Medicines Corp | compostos e composições úteis para tratamento de distúrbios relacionados ao ntrk |
| RU2018122089A (ru) | 2015-11-19 | 2019-12-25 | Блюпринт Медсинс Корпорейшн | Соединения и композиции, подходящие для лечения расстройств, связанных с ntrk |
| US10508106B2 (en) * | 2015-11-25 | 2019-12-17 | Convergene Llc | Bicyclic BET bromodomain inhibitors and uses thereof |
| ES2941687T3 (es) * | 2016-03-24 | 2023-05-24 | Cothera Bioscience Inc | Tratamiento del cáncer con TG02 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
| CA3039220A1 (en) * | 2016-10-26 | 2018-05-03 | Icahn School Of Medicine At Mount Sinai | Method for increasing cell proliferation in pancreatic beta cells, treatment method, and composition |
| MX393780B (es) | 2017-01-17 | 2025-03-24 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos |
| KR20190110588A (ko) * | 2017-01-23 | 2019-09-30 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 피리딘 화합물 |
| WO2018161876A1 (zh) * | 2017-03-08 | 2018-09-13 | 中国科学院上海药物研究所 | 二氢喹喔啉类溴结构域识别蛋白抑制剂及制备方法和用途 |
| CN107118210A (zh) * | 2017-04-28 | 2017-09-01 | 贵州大学 | 一种3‑碘‑6‑（三氟甲基）咪唑并[1,2‑a]吡啶的制备工艺 |
| US11547712B2 (en) | 2017-11-20 | 2023-01-10 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| CN111819193A (zh) | 2018-01-05 | 2020-10-23 | 西奈山伊坎医学院 | 增加胰腺β细胞增殖的方法、治疗方法以及组合物 |
| AU2019240065A1 (en) | 2018-03-20 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| MX2021007738A (es) | 2018-12-27 | 2021-08-05 | Nexys Therapeutics Inc | Derivados de (piridin-2-il)amina como inhibidores de tgf-beta r1 (alk5) para el tratamiento de cancer. |
| US20220017483A1 (en) * | 2018-12-28 | 2022-01-20 | Sichuan-Kelun-Biotech Biopharmaceutical Co., Ltd | Aminopyridine compound, preparation method therefor and use thereof |
| PH12021500043A1 (en) | 2019-03-29 | 2022-06-06 | Sumitomo Chemical Co | Heterocyclic compound and harmful arthropod pest control composition containing same |
| US12247015B2 (en) | 2019-04-29 | 2025-03-11 | Solent Therapeutics, Llc | 3-amino-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of MRGX2 |
| US12441707B2 (en) | 2019-12-30 | 2025-10-14 | Tyra Biosciences, Inc. | Indazole compounds |
| CN115916759B (zh) * | 2020-06-19 | 2025-07-15 | 泰州红云制药有限公司 | 取代喹唑啉类化合物、其制备方法、药物组合及应用 |
| US20230234935A1 (en) * | 2020-06-26 | 2023-07-27 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
| BR112023005876A2 (pt) | 2020-09-30 | 2023-05-02 | Sumitomo Chemical Co | Composto heterocíclico e composição de controle de artrópode nocivo contendo o mesmo |
| CN112225736B (zh) * | 2020-11-12 | 2022-04-15 | 山东省科学院菏泽分院 | 一种6-溴咪唑并[1.2-a]吡啶-3-甲醛的制备方法 |
| US20240277852A1 (en) * | 2021-05-20 | 2024-08-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors and degraders of pip4k protein |
| CN113416181B (zh) * | 2021-08-02 | 2022-05-03 | 四川大学 | 喹唑啉类衍生物及其用途 |
| CN114292259B (zh) * | 2021-11-30 | 2023-06-27 | 西安交通大学 | 4-氨基酸侧链取代的喹唑啉衍生物及其应用 |
| WO2023107714A2 (en) * | 2021-12-10 | 2023-06-15 | Prothena Biosciences Limited | Methods for treating neurological disorders |
| EP4596547A1 (en) | 2022-09-30 | 2025-08-06 | Sumitomo Chemical Company, Limited | Heterocyclic compound and harmful arthropod-controlling composition containing same |
| WO2024096093A1 (ja) | 2022-11-04 | 2024-05-10 | 住友化学株式会社 | 複素環化合物及びそれを含有する有害節足動物防除組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7320789B2 (en) * | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| EP1720855A4 (en) * | 2004-03-02 | 2008-12-17 | Smithkline Beecham Corp | HEMMER OF ACT ACTIVITY |
| AU2005295734A1 (en) * | 2004-10-15 | 2006-04-27 | Biogen Idec Ma Inc. | Methods of treating vascular injuries |
| US9259426B2 (en) * | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| ATE522249T1 (de) * | 2007-07-26 | 2011-09-15 | Novartis Ag | Organische verbindungen |
| WO2009032653A1 (en) | 2007-08-31 | 2009-03-12 | Smith Kline Beecham Corporation | Inhibitors of akt activity |
| EA201201081A1 (ru) * | 2010-02-05 | 2013-03-29 | Мерк Патент Гмбх | Производные гетарил[1,8]нафтиридина |
| JP6104824B2 (ja) * | 2011-03-09 | 2017-03-29 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ピリド［２，３−ｂ］ピラジン誘導体およびそれらの治療的使用 |
| TR201808033T4 (tr) * | 2011-07-13 | 2018-06-21 | Tiumbio Co Ltd | Alk5 ve veya alk4 inhibitörleri olarak 2 pridil ikameli imidazollar. |
| CN104837832B (zh) * | 2012-10-05 | 2019-04-26 | 里格尔药品股份有限公司 | Gdf-8抑制剂 |
| WO2015157093A1 (en) * | 2014-04-08 | 2015-10-15 | Rigel Pharmaceuticals, Inc. | 2,3-disubstituted pyridine compounds as tgf-beta inhibitors and methods of use |
-
2015
- 2015-04-02 WO PCT/US2015/024146 patent/WO2015157093A1/en not_active Ceased
- 2015-04-02 JP JP2016561626A patent/JP6767875B2/ja not_active Expired - Fee Related
- 2015-04-02 US US15/128,051 patent/US10233170B2/en active Active
- 2015-04-02 CN CN201580030111.XA patent/CN106536507B/zh not_active Expired - Fee Related
- 2015-04-02 ES ES15716690T patent/ES2759240T3/es active Active
- 2015-04-02 EP EP15716690.1A patent/EP3129367B1/en active Active
- 2015-04-08 TW TW104111332A patent/TW201623279A/zh unknown
- 2015-04-08 UY UY0001036068A patent/UY36068A/es unknown
-
2019
- 2019-01-16 US US16/249,458 patent/US10858335B2/en not_active Expired - Fee Related
- 2019-07-22 JP JP2019134857A patent/JP2019196387A/ja not_active Withdrawn
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