JP2009091362A - 高含量ファムシクロビル錠剤 - Google Patents
高含量ファムシクロビル錠剤 Download PDFInfo
- Publication number
- JP2009091362A JP2009091362A JP2008295818A JP2008295818A JP2009091362A JP 2009091362 A JP2009091362 A JP 2009091362A JP 2008295818 A JP2008295818 A JP 2008295818A JP 2008295818 A JP2008295818 A JP 2008295818A JP 2009091362 A JP2009091362 A JP 2009091362A
- Authority
- JP
- Japan
- Prior art keywords
- famciclovir
- tablet
- tablets
- lactose
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
【解決手段】ファムシクロビルが活性成分であって、錠剤中のファムシクロビルの重量パーセンテージが85%かまたはそれ以上であり、ラクトースの重量パーセンテージが15%未満である医薬錠剤を提供することにより、上記課題が解決される。
【選択図】なし
Description
適当な錠剤は、15%未満、10%未満、5%未満および好ましくは0%の無水ラクトースまたは他の同様な賦形剤、例えば微晶質セルロースを含有する。
錠剤は、当該分野において既知の従来の圧縮法によって調製されてもよい。好ましい方法において、ファムシクロビルはヒドロキシプロピルセルロースのごとき賦形剤とともに顆粒化して、活性成分の物質形態におけるいずれかの変化の影響を最小化する。顆粒をスクリーンし、乾燥し、次いでいずれかのさらなる賦形剤と混合して、圧縮混合物を形成する。錠剤は、必要な投薬量に適するサイズおよび重量に圧縮し、次いで所望により被覆してもよい。
被覆された錠剤の場合、中心部重量の2.5%はコーティングによって付加され、被覆錠剤は、500mg投薬量に対して560mg、および750mg投薬量に対して840mgの重量である。
750mg錠剤での得られる長円形表面のサイズは、19mm x 9mmであって、500mg錠剤では17mm x 8mmである。
Claims (7)
- ファムシクロビルが活性成分であって、錠剤中のファムシクロビルの重量パーセンテージが85%かまたはそれ以上である医薬錠剤。
- 15%未満のラクトースを含有する請求項1記載の医薬錠剤。
- 5%未満のラクトースを含有する請求項1または2記載の医薬錠剤。
- 0%のラクトースを含有する請求項1、2または3記載の医薬錠剤。
- 錠剤中のファムシクロビルの重量パーセンテージが90%かまたはそれ以上である
請求項1、2、3または4記載の医薬錠剤。 - ファムシクロビルおよび賦形剤を顆粒化し、次いで圧縮して打錠する、請求項1ないし6のいずれか1項記載の錠剤の調製方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9600847.9A GB9600847D0 (en) | 1996-01-16 | 1996-01-16 | Pharmaceuticals |
GB9600847.9 | 1996-01-16 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52569297A Division JP4711360B2 (ja) | 1996-01-16 | 1997-01-13 | 高含量ファムシクロビル錠剤 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009091362A true JP2009091362A (ja) | 2009-04-30 |
JP2009091362A6 JP2009091362A6 (ja) | 2009-07-09 |
JP2009091362A5 JP2009091362A5 (ja) | 2011-04-14 |
Family
ID=10787105
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52569297A Expired - Lifetime JP4711360B2 (ja) | 1996-01-16 | 1997-01-13 | 高含量ファムシクロビル錠剤 |
JP2008295818A Pending JP2009091362A (ja) | 1996-01-16 | 2008-11-19 | 高含量ファムシクロビル錠剤 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52569297A Expired - Lifetime JP4711360B2 (ja) | 1996-01-16 | 1997-01-13 | 高含量ファムシクロビル錠剤 |
Country Status (38)
Country | Link |
---|---|
US (1) | US6765007B1 (ja) |
EP (1) | EP0874632B1 (ja) |
JP (2) | JP4711360B2 (ja) |
KR (1) | KR100338829B1 (ja) |
CN (1) | CN1132582C (ja) |
AP (2) | AP747A (ja) |
AR (1) | AR005456A1 (ja) |
AT (1) | ATE220910T1 (ja) |
AU (1) | AU713090B2 (ja) |
BG (1) | BG63488B1 (ja) |
BR (1) | BR9706982A (ja) |
CY (1) | CY2390B1 (ja) |
CZ (1) | CZ287205B6 (ja) |
DE (1) | DE69714215T2 (ja) |
DK (1) | DK0874632T3 (ja) |
DZ (1) | DZ2159A1 (ja) |
EA (1) | EA001946B1 (ja) |
EG (1) | EG23684A (ja) |
ES (1) | ES2180922T3 (ja) |
GB (1) | GB9600847D0 (ja) |
HK (1) | HK1016473A1 (ja) |
HU (1) | HU225472B1 (ja) |
IL (1) | IL124913A0 (ja) |
MX (1) | MX9805713A (ja) |
MY (1) | MY127527A (ja) |
NO (1) | NO315689B1 (ja) |
NZ (1) | NZ326769A (ja) |
OA (1) | OA10812A (ja) |
PE (1) | PE35498A1 (ja) |
PL (1) | PL187291B1 (ja) |
PT (1) | PT874632E (ja) |
SK (1) | SK282132B6 (ja) |
TR (1) | TR199800954T2 (ja) |
TW (1) | TW434016B (ja) |
UA (1) | UA63897C2 (ja) |
UY (2) | UY24437A1 (ja) |
WO (1) | WO1997025990A1 (ja) |
ZA (1) | ZA97310B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015063521A (ja) * | 2013-09-02 | 2015-04-09 | 科研製薬株式会社 | 高い薬物含有率を有する錠剤及びその製造方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100136106A1 (en) * | 2005-06-08 | 2010-06-03 | Gary Liversidge | Modified Release Famciclovir Compositions |
CN102470237A (zh) | 2009-06-26 | 2012-05-23 | 塔里斯生物医药公司 | 用于可植入药物递送装置的固体药物片剂 |
CN104434852B (zh) * | 2013-09-18 | 2018-11-20 | 北京韩美药品有限公司 | 泛昔洛韦直压片及其制备方法 |
CN112587491B (zh) * | 2021-01-03 | 2022-08-23 | 迪沙药业集团有限公司 | 一种泛昔洛韦片组合物 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0165750A2 (en) * | 1984-06-12 | 1985-12-27 | MASCHINEN UND WERKZEUGBAU MICHAEL BRÜMMER GmbH | Elastic roll for treating thermoplastic film |
JPS6185388A (ja) * | 1984-09-20 | 1986-04-30 | ビーチャム・グループ・ピーエルシー | 新規化合物,その製法及びそれを含む医薬組成物 |
JPH1151625A (ja) * | 1997-08-07 | 1999-02-26 | Meidensha Corp | パラメータ調節方法及び装置 |
JP2000273045A (ja) * | 1991-01-30 | 2000-10-03 | Wellcome Found Ltd:The | 水分散性錠剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2126255C1 (ru) | 1991-05-15 | 1999-02-20 | Йель Юниверсити | Способ получения противоопухолевого эффекта у млекопитающих |
GB9303157D0 (en) * | 1993-02-17 | 1993-03-31 | Scotia Holdings Plc | Treatment of a group of related disorders |
IL111138A (en) | 1993-10-05 | 1997-04-15 | Smithkline Beecham Plc | Pharmaceutical compositions comprising penciclovir and/or its bioprecursor and/or its derivatives for the treatment and prophylaxis of post-herpetic neuralgia |
-
1996
- 1996-01-16 GB GBGB9600847.9A patent/GB9600847D0/en active Pending
-
1997
- 1997-01-02 AP APAP/P/1997/000911A patent/AP747A/en active
- 1997-01-10 UY UY24437A patent/UY24437A1/es not_active IP Right Cessation
- 1997-01-13 DK DK97901539T patent/DK0874632T3/da active
- 1997-01-13 PT PT97901539T patent/PT874632E/pt unknown
- 1997-01-13 UA UA98063199A patent/UA63897C2/uk unknown
- 1997-01-13 ES ES97901539T patent/ES2180922T3/es not_active Expired - Lifetime
- 1997-01-13 NZ NZ326769A patent/NZ326769A/xx not_active IP Right Cessation
- 1997-01-13 US US09/101,926 patent/US6765007B1/en not_active Expired - Lifetime
- 1997-01-13 HU HU9901021A patent/HU225472B1/hu unknown
- 1997-01-13 SK SK956-98A patent/SK282132B6/sk not_active IP Right Cessation
- 1997-01-13 AP APAP/P/1998/001298A patent/AP1114A/en active
- 1997-01-13 AT AT97901539T patent/ATE220910T1/de active
- 1997-01-13 EA EA199800573A patent/EA001946B1/ru not_active IP Right Cessation
- 1997-01-13 TR TR1998/00954T patent/TR199800954T2/xx unknown
- 1997-01-13 PL PL97327922A patent/PL187291B1/pl unknown
- 1997-01-13 IL IL12491397A patent/IL124913A0/xx not_active IP Right Cessation
- 1997-01-13 CN CN97191703A patent/CN1132582C/zh not_active Expired - Lifetime
- 1997-01-13 WO PCT/EP1997/000195 patent/WO1997025990A1/en active IP Right Grant
- 1997-01-13 DE DE69714215T patent/DE69714215T2/de not_active Expired - Lifetime
- 1997-01-13 AU AU15418/97A patent/AU713090B2/en not_active Expired
- 1997-01-13 BR BR9706982A patent/BR9706982A/pt not_active IP Right Cessation
- 1997-01-13 EP EP97901539A patent/EP0874632B1/en not_active Expired - Lifetime
- 1997-01-13 CZ CZ19982254A patent/CZ287205B6/cs not_active IP Right Cessation
- 1997-01-13 JP JP52569297A patent/JP4711360B2/ja not_active Expired - Lifetime
- 1997-01-13 KR KR1019980705371A patent/KR100338829B1/ko not_active IP Right Cessation
- 1997-01-14 EG EG4697A patent/EG23684A/xx active
- 1997-01-14 AR ARP970100130A patent/AR005456A1/es active IP Right Grant
- 1997-01-14 TW TW086100335A patent/TW434016B/zh not_active IP Right Cessation
- 1997-01-15 MY MYPI97000137A patent/MY127527A/en unknown
- 1997-01-15 ZA ZA9700310A patent/ZA97310B/xx unknown
- 1997-01-15 PE PE1997000022A patent/PE35498A1/es not_active IP Right Cessation
- 1997-01-15 DZ DZ970004A patent/DZ2159A1/fr active
- 1997-05-16 UY UY24556A patent/UY24556A1/es not_active IP Right Cessation
-
1998
- 1998-07-15 BG BG102638A patent/BG63488B1/bg unknown
- 1998-07-15 NO NO19983259A patent/NO315689B1/no not_active IP Right Cessation
- 1998-07-15 MX MX9805713A patent/MX9805713A/es unknown
- 1998-07-16 OA OA9800116A patent/OA10812A/en unknown
-
1999
- 1999-04-08 HK HK99101423A patent/HK1016473A1/xx not_active IP Right Cessation
-
2003
- 2003-11-28 CY CY0300085A patent/CY2390B1/xx unknown
-
2008
- 2008-11-19 JP JP2008295818A patent/JP2009091362A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0165750A2 (en) * | 1984-06-12 | 1985-12-27 | MASCHINEN UND WERKZEUGBAU MICHAEL BRÜMMER GmbH | Elastic roll for treating thermoplastic film |
JPS6185388A (ja) * | 1984-09-20 | 1986-04-30 | ビーチャム・グループ・ピーエルシー | 新規化合物,その製法及びそれを含む医薬組成物 |
JP2000273045A (ja) * | 1991-01-30 | 2000-10-03 | Wellcome Found Ltd:The | 水分散性錠剤 |
JPH1151625A (ja) * | 1997-08-07 | 1999-02-26 | Meidensha Corp | パラメータ調節方法及び装置 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015063521A (ja) * | 2013-09-02 | 2015-04-09 | 科研製薬株式会社 | 高い薬物含有率を有する錠剤及びその製造方法 |
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