JP2009051855A - 苦味等を隠蔽した経口薬剤 - Google Patents
苦味等を隠蔽した経口薬剤 Download PDFInfo
- Publication number
- JP2009051855A JP2009051855A JP2008270138A JP2008270138A JP2009051855A JP 2009051855 A JP2009051855 A JP 2009051855A JP 2008270138 A JP2008270138 A JP 2008270138A JP 2008270138 A JP2008270138 A JP 2008270138A JP 2009051855 A JP2009051855 A JP 2009051855A
- Authority
- JP
- Japan
- Prior art keywords
- unpleasant taste
- drugs
- hydrochloride
- drug
- syrup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
【解決手段】不快な味を有する塩基性薬物およびアニオン性高分子物質を含有する不快な味を隠蔽した経口薬剤組成物。アニオン性高分子物質としては、カラギーナン、コンドロイチン硫酸等、デキストラン硫酸、アルギン酸、ジェランガム、キサンタンガム等が挙げられる。不快な味を有する薬物としては、例えば抗痴呆薬、抗血小板薬、抗うつ薬、脳循環代謝改善薬、抗アレルギー薬等が挙げられる。
【選択図】なし
Description
2mg/mlの塩酸ドネペジル水溶液を調製し、その5mlにκ−カラギーナン、コンドロイチン硫酸またはデキストラン硫酸を50mg溶解後、2名の被験者(表中A、Bで示す)が全量を口に含み、苦味としびれの程度を5段階で評価した。結果を表1に示した。表1から明らかなように、κ−カラギーナン等の添加によって塩酸ドネペジルの苦味は顕著に抑制された。
塩酸チクロピジン(20mg/ml)、塩酸マプロチリン(5mg/ml)および酒石酸イフェンプロジル(4mg/ml)を用い、カラギーナンの苦味としびれの隠蔽効果を調べた。試験方法、評価基準は試験例1に準じた。結果を表2に示した。
Claims (4)
- 不快な味を有する塩基性薬物と、コンドロイチン硫酸、デキストラン硫酸、アルギン酸、ジェランガムおよびキサンタンガム並びにこれらの塩からなるアニオン性高分子から選ばれる1種以上のアニオン性高分子物質とを含有する、経口用液剤、シロップ剤またはゼリー剤。
- 不快な味を有する薬剤が、抗生物質、抗痴呆薬、抗血小板薬、抗うつ薬、脳循環代謝改善薬または抗アレルギー薬から選ばれる1種以上である、
請求項1に記載の経口用液剤、シロップ剤またはゼリー剤。 - 不快な味を有する薬剤が、塩酸ドネペジル、塩酸チクロピジン、塩酸マプロチリン、酒石酸イフェンプロジルまたは塩酸セフカペンピボキシルから選ばれる1種以上である、
請求項1または2に記載の経口用液剤、シロップ剤またはゼリー剤。 - 塩基性薬物1重量部に対して、アニオン性高分子物質0.1〜20重量部を含む、
請求項1〜3のいずれかに記載の経口用液剤、シロップ剤またはゼリー剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008270138A JP5053228B2 (ja) | 1997-03-28 | 2008-10-20 | 苦味等を隠蔽した経口薬剤 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1997078568 | 1997-03-28 | ||
JP7856897 | 1997-03-28 | ||
JP34326597 | 1997-12-12 | ||
JP1997343265 | 1997-12-12 | ||
JP2008270138A JP5053228B2 (ja) | 1997-03-28 | 2008-10-20 | 苦味等を隠蔽した経口薬剤 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004329382A Division JP4234666B2 (ja) | 1997-03-28 | 2004-11-12 | 苦味等を隠蔽した経口薬剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009051855A true JP2009051855A (ja) | 2009-03-12 |
JP5053228B2 JP5053228B2 (ja) | 2012-10-17 |
Family
ID=26419628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008270138A Expired - Lifetime JP5053228B2 (ja) | 1997-03-28 | 2008-10-20 | 苦味等を隠蔽した経口薬剤 |
Country Status (9)
Country | Link |
---|---|
US (1) | US7727552B1 (ja) |
EP (1) | EP0974366B1 (ja) |
JP (1) | JP5053228B2 (ja) |
KR (1) | KR100693266B1 (ja) |
AT (1) | ATE342735T1 (ja) |
DE (1) | DE69836207T2 (ja) |
DK (1) | DK0974366T3 (ja) |
ES (1) | ES2273409T3 (ja) |
WO (1) | WO1998043675A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011231051A (ja) * | 2010-04-28 | 2011-11-17 | Zeria Pharmaceutical Co Ltd | ビタミンb1類含有経口ゼリー剤 |
JP2014501256A (ja) * | 2010-12-23 | 2014-01-20 | コルゲート・パーモリブ・カンパニー | 口腔ケア流体組成物 |
JP2015536136A (ja) * | 2012-10-25 | 2015-12-21 | ネステク ソシエテ アノニム | カプセル化された苦味ペプチド、苦味ペプチドをカプセル化する方法、及びカプセル化された苦味ペプチドを含む栄養組成物 |
WO2018124283A1 (ja) | 2016-12-28 | 2018-07-05 | 富山化学工業株式会社 | 医薬組成物 |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100801236B1 (ko) * | 1998-08-28 | 2008-02-11 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 고미 등을 경감한 의약조성물 |
KR20000046974A (ko) * | 1998-12-31 | 2000-07-25 | 윤재승 | 아세글루타미드 알루미늄의 경구 투여용 제제 조성물ㅇ |
US6432448B1 (en) * | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
IL155959A0 (en) | 2000-11-28 | 2003-12-23 | Fmc Corp | Edible pga (propylene glycol alginate) coating composition |
JP4334869B2 (ja) * | 2000-12-01 | 2009-09-30 | 協和発酵キリン株式会社 | 溶解性または経口吸収性の改善された組成物 |
JP4743684B2 (ja) * | 2002-05-22 | 2011-08-10 | 塩野義製薬株式会社 | 難水溶性薬物の溶出性を改善する方法 |
US20050232990A1 (en) * | 2003-12-31 | 2005-10-20 | Garth Boehm | Donepezil formulations |
CN101951923B (zh) | 2007-12-20 | 2013-10-30 | N.V.努特里奇亚 | 含核苷酸/核苷的液态产品 |
US20110124577A1 (en) * | 2008-07-30 | 2011-05-26 | Suntory Holdings Limited | Preparation for oral administration comprises quercetin glycoside and a water-based solvent extract of cartilage containing chondroitin sulfate |
US8715715B2 (en) | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
EP2243473B1 (en) | 2009-04-17 | 2018-08-08 | Hexal AG | Tablets comprising a taste masking agent |
EP2366378A1 (en) | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulations |
SG188509A1 (en) | 2010-09-13 | 2013-04-30 | Bev Rx Inc | Aqueous drug delivery system comprising off - flavor masking agent |
EP2468254A1 (en) | 2010-12-15 | 2012-06-27 | Hexal AG | Orally disintegrating tablet having a taste masking effect |
AU2014307803A1 (en) | 2013-08-16 | 2016-03-10 | Universiteit Maastricht | Treatment of cognitive impairment with PDE4 inhibitor |
CN106727272A (zh) * | 2016-12-08 | 2017-05-31 | 星康桥医药科技(南京)有限公司 | 一种漱口制剂及漱口方法 |
KR20200064951A (ko) | 2018-11-29 | 2020-06-08 | 동국제약 주식회사 | 약리학적 활성 성분을 함유한 구강붕해필름 및 그의 제조방법 |
EP4284347A1 (en) | 2021-01-28 | 2023-12-06 | Galvita AG | Solid pharmaceutical compositions and methods of producing the same |
EP4311543A1 (en) | 2022-07-27 | 2024-01-31 | Galvita AG | Methods for loading template inverted carriers |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63309150A (ja) * | 1987-06-11 | 1988-12-16 | San Ei Chem Ind Ltd | 即席ゲル状物の製造法 |
JPH04235136A (ja) * | 1991-01-08 | 1992-08-24 | Kibun Foods Inc | 苦味低減方法及び苦味低減化組成物 |
JPH05163154A (ja) * | 1991-12-13 | 1993-06-29 | Kanebo Ltd | 経口液剤 |
JPH08333245A (ja) * | 1995-06-07 | 1996-12-17 | Taisho Pharmaceut Co Ltd | イブプロフェン懸濁液剤 |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5176413A (ja) | 1974-12-25 | 1976-07-02 | Toyo Jozo Kk | Hifukuzainoseizoho |
JPS5476818A (en) * | 1977-11-25 | 1979-06-19 | Egyt Gyogyszervegyeszeti Gyar | Pharmaceutical composition having prolonged effect and production thereof |
JPS5565741A (en) * | 1978-11-10 | 1980-05-17 | Tokico Ltd | Shock absorber |
GB2122892B (en) | 1982-07-02 | 1986-01-29 | Squibb & Sons Inc | Nystantin pastille formulation |
JPS60204712A (ja) | 1984-03-29 | 1985-10-16 | Ss Pharmaceut Co Ltd | 塩酸メクリジンの安定化液状組成物 |
JPS61130239A (ja) | 1984-11-30 | 1986-06-18 | Dai Ichi Seiyaku Co Ltd | 複合体 |
US5286489A (en) * | 1985-08-26 | 1994-02-15 | The Procter & Gamble Company | Taste masking compositions |
JPH0717498B2 (ja) | 1989-05-31 | 1995-03-01 | 興和株式会社 | 鎮咳去痰ソフトカプセル剤 |
US5084278A (en) | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
US5013557A (en) * | 1989-10-03 | 1991-05-07 | Warner-Lambert Company | Taste masking compositions comprising spray dried microcapsules containing sucralfate and methods for preparing same |
US5077053A (en) | 1990-02-12 | 1991-12-31 | Warner-Lambert Company | Zein as a moisture barrier for sugarless edible compositions and method for preparing same |
JPH03287535A (ja) | 1990-03-31 | 1991-12-18 | Bairon Boeki Kk | プラノプロフェン水溶液 |
JPH0418015A (ja) | 1990-05-10 | 1992-01-22 | Fujikawa Kk | 安定なフマル酸クレマスチン水溶液 |
JP3073544B2 (ja) | 1991-02-18 | 2000-08-07 | 三栄源エフ・エフ・アイ株式会社 | 塩化カリウムの脱苦味方法 |
JPH04282312A (ja) | 1991-03-08 | 1992-10-07 | Eisai Co Ltd | コ−ティング層を有する粒状物 |
JP2508555B2 (ja) | 1991-05-24 | 1996-06-19 | 株式会社紀文食品 | 苦味低減方法 |
CA2068402C (en) | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
DE4122217C2 (de) | 1991-07-04 | 1997-02-13 | Merz & Co Gmbh & Co | Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern |
NZ246091A (en) | 1991-12-24 | 1995-08-28 | Yamanouchi Pharma Co Ltd | Intrabuccally disintegrating preparation containing an active ingredient, agar, and lactose and/or mannitol |
JP3069458B2 (ja) | 1992-01-29 | 2000-07-24 | 武田薬品工業株式会社 | 口腔内崩壊型錠剤およびその製造法 |
JPH06218028A (ja) | 1992-10-02 | 1994-08-09 | Eisai Co Ltd | 湿製錠の成型方法とその装置及び湿製錠 |
WO1994013257A1 (en) | 1992-12-16 | 1994-06-23 | Creative Products Resource Associates, Ltd. | Occlusive/semi-occlusive lotion for treatment of a skin disease or disorder |
ATE181672T1 (de) * | 1993-04-28 | 1999-07-15 | Takeda Chemical Industries Ltd | Geschmacksmaskierte feste zubereitung und verfahren zur herstellung |
US5827507A (en) | 1993-10-01 | 1998-10-27 | Kao Corporation | Ultraviolet shielding composite fine particles, method for producing the same, and cosmetics |
US5576014A (en) | 1994-01-31 | 1996-11-19 | Yamanouchi Pharmaceutical Co., Ltd | Intrabuccally dissolving compressed moldings and production process thereof |
JPH07267850A (ja) | 1994-03-28 | 1995-10-17 | Eisai Co Ltd | 不快味を防止した医薬組成物及びその製造方法 |
US5672364A (en) | 1994-07-07 | 1997-09-30 | Sankyo Seisakusho Co. & Eisai Co., Ltd. | Apparatus for manufacturing tablets |
JP3187657B2 (ja) | 1994-07-08 | 2001-07-11 | 株式会社三共製作所 | 錠剤製造方法およびその装置 |
DE4432757A1 (de) | 1994-09-14 | 1996-03-21 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Metformin und Verfahren zu deren Herstellung |
US5656284A (en) * | 1995-04-24 | 1997-08-12 | Balkin; Michael S. | Oral transmucosal delivery tablet and method of making it |
SK74396A3 (en) | 1995-06-13 | 1997-04-09 | American Home Prod | Organoleptically acceptable oral pharmaceutical compositions |
TW442287B (en) | 1995-06-13 | 2001-06-23 | American Home Produits Corp | Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac) |
JPH0948726A (ja) | 1995-08-07 | 1997-02-18 | Tanabe Seiyaku Co Ltd | 口腔内速崩壊性製剤およびその製法 |
JPH09143100A (ja) | 1995-11-20 | 1997-06-03 | Sumitomo Pharmaceut Co Ltd | 服用感の改善された固形製剤 |
US6214386B1 (en) | 1995-11-22 | 2001-04-10 | Recordati, S.A. | Prompt-release oral pharmaceutical compositions for extemporaneous suspensions |
US5612026A (en) * | 1996-01-25 | 1997-03-18 | The Procter & Gamble Company | Cholesterol lowering drink mix compositons |
JPH103629A (ja) | 1996-06-14 | 1998-01-06 | Asahi Komagu Kk | 薄膜磁気ヘッドスライダーの製造方法 |
WO1998002185A1 (fr) | 1996-07-12 | 1998-01-22 | Daiichi Pharmaceutical Co., Ltd. | Materiaux moules par compression, a desagregation rapide, et leur procede de production |
US5763449A (en) | 1996-08-07 | 1998-06-09 | Ascent Pediatrics, Inc. | Pleasant-tasting aqueous liquid composition of a bitter-tasting drug |
JPH10114683A (ja) | 1996-10-11 | 1998-05-06 | Kobayashi Seiyaku Kogyo Kk | 非ステロイド性解熱鎮痛消炎剤を含む固形製剤及びその製造方法 |
US5962535A (en) | 1997-01-17 | 1999-10-05 | Takeda Chemical Industries, Ltd. | Composition for alzheimer's disease |
JP4234666B2 (ja) | 1997-03-28 | 2009-03-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 苦味等を隠蔽した経口薬剤 |
JP3770518B2 (ja) | 1997-03-28 | 2006-04-26 | エーザイ株式会社 | 苦味等を隠蔽した経口薬剤 |
TW580397B (en) | 1997-05-27 | 2004-03-21 | Takeda Chemical Industries Ltd | Solid preparation |
JP3797764B2 (ja) | 1997-10-01 | 2006-07-19 | エーザイ株式会社 | 光安定化組成物 |
TW527195B (en) | 1997-10-09 | 2003-04-11 | Ssp Co Ltd | Fast-soluble solid pharmaceutical combinations |
JPH11199517A (ja) | 1997-10-31 | 1999-07-27 | Meiji Seika Kaisha Ltd | 口腔内速崩壊性錠剤 |
US6368625B1 (en) | 1998-08-12 | 2002-04-09 | Cima Labs Inc. | Orally disintegrable tablet forming a viscous slurry |
KR100801236B1 (ko) | 1998-08-28 | 2008-02-11 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 고미 등을 경감한 의약조성물 |
EP1120120A4 (en) | 1998-10-05 | 2009-04-29 | Eisai R&D Man Co Ltd | TABLETS DISSOLVING DIRECTLY IN MOUTH |
WO2000025754A2 (en) | 1998-11-04 | 2000-05-11 | Mcneil-Ppc, Inc. | Solid oral dosage forms containing alginic acid and famotidine |
US6656492B2 (en) | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
-
1998
- 1998-03-26 EP EP98911029A patent/EP0974366B1/en not_active Expired - Lifetime
- 1998-03-26 AT AT98911029T patent/ATE342735T1/de active
- 1998-03-26 WO PCT/JP1998/001360 patent/WO1998043675A1/ja active IP Right Grant
- 1998-03-26 DE DE69836207T patent/DE69836207T2/de not_active Expired - Lifetime
- 1998-03-26 DK DK98911029T patent/DK0974366T3/da active
- 1998-03-26 KR KR1019997008568A patent/KR100693266B1/ko not_active IP Right Cessation
- 1998-03-26 ES ES98911029T patent/ES2273409T3/es not_active Expired - Lifetime
- 1998-03-26 US US09/380,310 patent/US7727552B1/en not_active Expired - Fee Related
-
2008
- 2008-10-20 JP JP2008270138A patent/JP5053228B2/ja not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63309150A (ja) * | 1987-06-11 | 1988-12-16 | San Ei Chem Ind Ltd | 即席ゲル状物の製造法 |
JPH04235136A (ja) * | 1991-01-08 | 1992-08-24 | Kibun Foods Inc | 苦味低減方法及び苦味低減化組成物 |
JPH05163154A (ja) * | 1991-12-13 | 1993-06-29 | Kanebo Ltd | 経口液剤 |
JPH08333245A (ja) * | 1995-06-07 | 1996-12-17 | Taisho Pharmaceut Co Ltd | イブプロフェン懸濁液剤 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011231051A (ja) * | 2010-04-28 | 2011-11-17 | Zeria Pharmaceutical Co Ltd | ビタミンb1類含有経口ゼリー剤 |
JP2014501256A (ja) * | 2010-12-23 | 2014-01-20 | コルゲート・パーモリブ・カンパニー | 口腔ケア流体組成物 |
JP2015536136A (ja) * | 2012-10-25 | 2015-12-21 | ネステク ソシエテ アノニム | カプセル化された苦味ペプチド、苦味ペプチドをカプセル化する方法、及びカプセル化された苦味ペプチドを含む栄養組成物 |
WO2018124283A1 (ja) | 2016-12-28 | 2018-07-05 | 富山化学工業株式会社 | 医薬組成物 |
US10849880B2 (en) | 2016-12-28 | 2020-12-01 | Fujifilm Toyama Chemical Co., Ltd. | Pharmaceutical composition |
Also Published As
Publication number | Publication date |
---|---|
DK0974366T3 (da) | 2007-01-29 |
US7727552B1 (en) | 2010-06-01 |
EP0974366B1 (en) | 2006-10-18 |
DE69836207T2 (de) | 2007-08-30 |
ATE342735T1 (de) | 2006-11-15 |
JP5053228B2 (ja) | 2012-10-17 |
DE69836207D1 (de) | 2006-11-30 |
KR100693266B1 (ko) | 2007-03-27 |
EP0974366A4 (en) | 2003-03-26 |
WO1998043675A1 (fr) | 1998-10-08 |
ES2273409T3 (es) | 2007-05-01 |
KR20010005510A (ko) | 2001-01-15 |
EP0974366A1 (en) | 2000-01-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5053228B2 (ja) | 苦味等を隠蔽した経口薬剤 | |
JP4445590B2 (ja) | パロキセチン−レジン含有の経口液体組成物 | |
US20030118654A1 (en) | Taste masked aqueous liquid pharmaceutical composition | |
JP4619658B2 (ja) | 快い味の経口懸濁液および方法 | |
JP2000505093A (ja) | 苦味薬剤の味の良い水性液体組成物 | |
JP4051717B2 (ja) | ビオチン含有内服液剤 | |
JP4264105B2 (ja) | イソソルビド含有ゼリー製剤 | |
JP3770518B2 (ja) | 苦味等を隠蔽した経口薬剤 | |
JP2009067790A (ja) | エカベトナトリウムの不快な味をマスキングしてなるゼリー状製剤 | |
WO2019241077A1 (en) | Oral eliglustat transmucosal delivery system | |
JP4234666B2 (ja) | 苦味等を隠蔽した経口薬剤 | |
JPH04327526A (ja) | 経口用固形製剤 | |
JP4190769B2 (ja) | 内服液組成物 | |
JP2002193839A (ja) | ココア製剤 | |
JP3935934B2 (ja) | イチョウの葉の乾操抽出物を含有する発泡性飲食用組成物 | |
JP4814636B2 (ja) | ビグアナイド系薬物の内服製剤 | |
JP3770515B2 (ja) | 薬物の苦味の隠蔽経口剤 | |
JP2006052169A (ja) | ゾル状又はゲル状の服薬補助食品 | |
JP4990515B2 (ja) | 味質の改善されたイソソルビド製剤 | |
JP4959864B2 (ja) | グルタミン酸塩含有液剤 | |
JP2000119198A (ja) | 苦味等の隠蔽されたホスフォジエステラーゼ阻害剤含有経口製剤 | |
JP2001342151A (ja) | 甘味を有する薬剤組成物 | |
EP2243473B1 (en) | Tablets comprising a taste masking agent | |
WO2004096214A1 (en) | A rapidly disintegrable composition for masking the bitter taste of ondansetron or a pharmaceutically acceptable salt thereof | |
JPH1036252A (ja) | ベラドンナ(総)アルカロイド配合内服液剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081114 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111026 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20111220 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111226 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120124 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120222 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120420 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120425 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120518 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120717 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120725 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150803 Year of fee payment: 3 |
|
EXPY | Cancellation because of completion of term |