JP2008537681A5 - - Google Patents
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- JP2008537681A5 JP2008537681A5 JP2008505892A JP2008505892A JP2008537681A5 JP 2008537681 A5 JP2008537681 A5 JP 2008537681A5 JP 2008505892 A JP2008505892 A JP 2008505892A JP 2008505892 A JP2008505892 A JP 2008505892A JP 2008537681 A5 JP2008537681 A5 JP 2008537681A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- serum
- embryonic stem
- cells
- avian embryonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 25
- 241000700605 Viruses Species 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 11
- 241000271566 Aves Species 0.000 claims 10
- 210000001671 embryonic stem cell Anatomy 0.000 claims 9
- 239000012679 serum free medium Substances 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 241000712461 unidentified influenza virus Species 0.000 claims 4
- 108010009736 Protein Hydrolysates Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000003531 protein hydrolysate Substances 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 230000001464 adherent effect Effects 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 239000012137 tryptone Substances 0.000 claims 2
- 241000722315 Arca zebra Species 0.000 claims 1
- 241000178270 Canarypox virus Species 0.000 claims 1
- 241000272201 Columbiformes Species 0.000 claims 1
- 240000008067 Cucumis sativus Species 0.000 claims 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims 1
- 125000002353 D-glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 241000282324 Felis Species 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 241000122235 Junco hyemalis Species 0.000 claims 1
- 241000287127 Passeridae Species 0.000 claims 1
- 241000286209 Phasianidae Species 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 241000287531 Psittacidae Species 0.000 claims 1
- 241000382353 Pupa Species 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000287181 Sturnus vulgaris Species 0.000 claims 1
- 241000725681 Swine influenza virus Species 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 238000005054 agglomeration Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229940023860 canarypox virus HIV vaccine Drugs 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000004017 serum-free culture medium Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0503583A FR2884255B1 (fr) | 2005-04-11 | 2005-04-11 | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| FR0503583 | 2005-04-11 | ||
| US72880705P | 2005-10-21 | 2005-10-21 | |
| US60/728,807 | 2005-10-21 | ||
| PCT/EP2006/061531 WO2006108846A1 (en) | 2005-04-11 | 2006-04-11 | Process of manufacturing viral vaccines in suspension avian embryonic derived stem cell lines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008537681A JP2008537681A (ja) | 2008-09-25 |
| JP2008537681A5 true JP2008537681A5 (enExample) | 2009-05-28 |
| JP5031726B2 JP5031726B2 (ja) | 2012-09-26 |
Family
ID=35057073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008505892A Expired - Fee Related JP5031726B2 (ja) | 2005-04-11 | 2006-04-11 | 懸濁鳥類胚性幹細胞株においてウイルスワクチンを製造する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8148132B2 (enExample) |
| EP (2) | EP1874918B1 (enExample) |
| JP (1) | JP5031726B2 (enExample) |
| KR (1) | KR101309568B1 (enExample) |
| CN (1) | CN101194012B (enExample) |
| AU (1) | AU2006234304B2 (enExample) |
| BR (1) | BRPI0609119A2 (enExample) |
| CA (1) | CA2604330C (enExample) |
| ES (2) | ES2555959T3 (enExample) |
| FR (1) | FR2884255B1 (enExample) |
| MX (1) | MX2007012777A (enExample) |
| NZ (2) | NZ562843A (enExample) |
| RU (1) | RU2457253C2 (enExample) |
| WO (1) | WO2006108846A1 (enExample) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2836924B1 (fr) | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| FR2884255B1 (fr) * | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| CN101365480B (zh) | 2005-11-01 | 2014-11-05 | 诺华疫苗和诊断有限两合公司 | 经由β-丙内酯处理的残留细胞DNA水平降低的细胞衍生病毒疫苗 |
| EA014028B1 (ru) | 2005-11-04 | 2010-08-30 | Новартис Вэксинс Энд Диагностикс Срл | Эмульсии, содержащие свободное поверхностно-активное вещество в водной фазе в качестве адъюванта сплит вакцин против гриппа |
| WO2007052058A1 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| NZ592713A (en) | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9 |
| AU2006310163B2 (en) | 2005-11-04 | 2011-09-15 | Seqirus UK Limited | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| HUE051122T2 (hu) | 2005-11-04 | 2021-03-01 | Seqirus Uk Ltd | Sejttenyészetben növesztett influenzavírusból elõállított nemvirion anti-géneket tartalmazó adjuvált vakcinák |
| HUE049580T2 (hu) | 2006-01-27 | 2020-09-28 | Seqirus Uk Ltd | Hemagglutinint és mátrixfehérjéket tartalmazó, influenza elleni oltóanyagok |
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| EP2500417A1 (en) * | 2006-08-09 | 2012-09-19 | Vivalis | Method of production of transgenic avian using embryonic stem cells |
| JP5257364B2 (ja) | 2006-10-25 | 2013-08-07 | インターベツト・インターナシヨナル・ベー・ベー | ネコインフルエンザワクチン及び使用方法 |
| EP1923070A1 (en) * | 2006-11-15 | 2008-05-21 | Intervet International BV | Vaccine for vaccinating feline against influenza virus |
| PL2121011T3 (pl) | 2006-12-06 | 2014-10-31 | Novartis Ag | Szczepionki zawierające antygeny czterech szczepów wirusa grypy |
| JP5578390B2 (ja) * | 2007-03-05 | 2014-08-27 | 株式会社 Ｍｂｒ | 細菌細胞壁骨格成分の製造方法 |
| EP1985305A1 (en) | 2007-04-24 | 2008-10-29 | Vivalis | Duck embryonic derived stem cell lines for the production of viral vaccines |
| EP2014279A1 (en) | 2007-06-22 | 2009-01-14 | Pevion Biotech AG | Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof |
| CN101784283A (zh) | 2007-06-27 | 2010-07-21 | 诺华有限公司 | 低添加流感疫苗 |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| KR101445433B1 (ko) * | 2008-02-25 | 2014-09-26 | 백스터 인터내셔널 인코포레이티드 | 연속 세포주 제조 방법 |
| EA201071086A1 (ru) | 2008-03-18 | 2011-04-29 | Новартис Аг | Усовершенствованный способ получения вакцинных антигенов вируса гриппа |
| MY172788A (en) | 2008-08-01 | 2019-12-12 | Gamma Vaccines Pty Ltd | Influenza vaccines |
| WO2010079081A1 (en) | 2009-01-07 | 2010-07-15 | Glaxosmithkline Biologicals S.A. | Methods for recovering a virus or a viral antigen produced by cell culture |
| CA2750055A1 (en) | 2009-02-06 | 2010-08-12 | Glaxosmithkline Biologicals S.A. | Method for purifying viruses using a density gradient |
| EP2396031A1 (en) | 2009-02-10 | 2011-12-21 | Novartis AG | Influenza vaccines with increased amounts of h3 antigen |
| US20120093859A1 (en) | 2009-02-10 | 2012-04-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
| EP3173097A3 (en) | 2009-02-10 | 2017-07-12 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| CN102548577A (zh) | 2009-04-27 | 2012-07-04 | 诺华有限公司 | 用于抵抗流感的佐剂疫苗 |
| US20120058145A1 (en) * | 2009-05-08 | 2012-03-08 | Bruno Rene Andre | Method for producing virus from cell culture involving homogenization |
| AU2010277310B2 (en) | 2009-07-31 | 2015-01-15 | Seqirus UK Limited | Reverse genetics systems |
| US20120237536A1 (en) | 2009-09-10 | 2012-09-20 | Novartis | Combination vaccines against respiratory tract diseases |
| US20130052219A1 (en) | 2009-09-30 | 2013-02-28 | Incorporated Administrative Agency National Agriculture And Food Research Organization | Preparation method of virus expressing alpha-galactose epitope and vaccine |
| GB0919117D0 (en) * | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
| NO2501822T3 (enExample) | 2009-11-17 | 2018-01-13 | ||
| US20120309056A1 (en) * | 2010-02-04 | 2012-12-06 | Leon Arnaud | Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells |
| AU2011225748A1 (en) | 2010-03-08 | 2012-09-13 | Novartis Ag | Methods of testing for intracellular pathogens |
| ES2562818T3 (es) | 2010-05-03 | 2016-03-08 | Glaxosmithkline Biologicals S.A. | Procedimiento de inactivación del virus de la gripe |
| EP2566323A2 (en) | 2010-05-06 | 2013-03-13 | Novartis AG | Organic peroxide compounds for microorganism inactivation |
| EP2571520B1 (en) | 2010-05-21 | 2018-04-04 | Seqirus UK Limited | Influenza virus reassortment method |
| AU2011262309B2 (en) | 2010-06-01 | 2015-08-13 | Seqirus UK Limited | Concentration of influenza vaccine antigens without lyophilization |
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| NZ603620A (en) * | 2010-07-20 | 2015-01-30 | Bavarian Nordic As | Method for harvesting expression products |
| US9517205B2 (en) | 2010-08-20 | 2016-12-13 | Seqirus UK Limited | Soluble needle arrays for delivery of influenza vaccines |
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| WO2012145375A1 (en) * | 2011-04-18 | 2012-10-26 | The Trustees Of Princeton University | Method to produce virus in cultured cells |
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| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| CN103157106B (zh) * | 2012-12-27 | 2014-07-23 | 瑞普（保定）生物药业有限公司 | 一种制备猪细小病毒病灭活疫苗的方法 |
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| CN114350601B (zh) * | 2021-12-21 | 2022-12-27 | 广东省华晟生物技术有限公司 | 樱桃谷鸭成纤维细胞系及其构建方法与应用 |
| CN114366831A (zh) * | 2022-01-10 | 2022-04-19 | 南京双威生物医学科技有限公司 | 一种基于核黄素光化学法的血浆病原体灭活处理方法 |
| CN119654339A (zh) | 2022-07-01 | 2025-03-18 | 特兰斯吉恩股份有限公司 | 包含表面活性蛋白-d和tnfsf成员的融合蛋白 |
| CN120380015A (zh) | 2022-08-18 | 2025-07-25 | 特兰斯吉恩公司 | 嵌合痘病毒 |
| CN118356484B (zh) * | 2024-04-19 | 2025-09-05 | 华南农业大学 | 一种md疫苗及其制备方法 |
| CN119162122B (zh) * | 2024-09-14 | 2025-10-03 | 江苏华诺泰生物医药科技有限公司 | 一种流感病毒维持液配方及其制备方法和应用 |
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| FR503583A (fr) | 1918-09-10 | 1920-06-14 | Francois Mauron | Installation pour le réglage du travail d'une dynamo à vitesse variable travaillant en parallèle avec une batterie d'accumulateurs |
| US5340740A (en) | 1992-05-15 | 1994-08-23 | North Carolina State University | Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process |
| FR2726003B1 (fr) | 1994-10-21 | 2002-10-18 | Agronomique Inst Nat Rech | Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires |
| DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| US5672485A (en) | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
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| PT841392E (pt) | 1996-11-12 | 2004-11-30 | Univ Auburn | Vacina viva atenuada de neospora |
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| DE60142506D1 (de) * | 2000-03-03 | 2010-08-19 | Chemo Sero Therapeut Res Inst | In serumfreier kultur verwendbare zelle, kultursuspension und verfahren zur virusproduktion als impfstoff unter verwendung der zelle |
| DE10144906B4 (de) * | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
| FR2836924B1 (fr) * | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| US6984811B2 (en) | 2002-03-11 | 2006-01-10 | Lg Electronics, Inc. | Door for microwave oven having integrally formed control unit |
| PT2287288E (pt) | 2002-07-09 | 2012-12-10 | Baxter Int | Meio isento de proteína animal para cultura de células |
| UA85543C2 (ru) * | 2002-09-05 | 2009-02-10 | Бавариан Нордик А/С | Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных |
| CA2510229A1 (en) | 2002-12-13 | 2004-07-08 | Aventis Pasteur, Inc. | Production of alvac on avian embryonic stem cells |
| US20040229335A1 (en) * | 2003-05-15 | 2004-11-18 | Introgen Therapeutics, Inc. | Methods and compositions for the production of adenoviral vectors |
| EP1500699A1 (en) * | 2003-07-22 | 2005-01-26 | Vivalis | Production of vaccinia virus with adherent or non adherent avian cell lines |
| JP4787156B2 (ja) * | 2003-07-22 | 2011-10-05 | ビバリス | 付着または非付着の鳥類細胞系を用いた、ポックスウィルスの作製法 |
| FR2884255B1 (fr) * | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| US20100111992A1 (en) * | 2006-05-01 | 2010-05-06 | The Regents Of The University Of California | Cytomegalovirus peptides and methods of use thereof |
-
2005
- 2005-04-11 FR FR0503583A patent/FR2884255B1/fr not_active Expired - Lifetime
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