UA85543C2 - Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных - Google Patents

Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных

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UA85543C2
UA85543C2 UAA200502041A UA2005002041A UA85543C2 UA 85543 C2 UA85543 C2 UA 85543C2 UA A200502041 A UAA200502041 A UA A200502041A UA 2005002041 A UA2005002041 A UA 2005002041A UA 85543 C2 UA85543 C2 UA 85543C2
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cultivation
composition
vaccinization
animals
amplification
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UAA200502041A
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English (en)
Ukrainian (uk)
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Ингмар Рете
Ева Фелдер
Карл Хеллер
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Бавариан Нордик А/С
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Application filed by Бавариан Нордик А/С filed Critical Бавариан Нордик А/С
Publication of UA85543C2 publication Critical patent/UA85543C2/ru

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Abstract

Изобретение относится к способу амплификации вируса, который включает этапы культивирования первичных птичьих клеток в безсывороточной среде, содержащей фактор, выбранный из группы, которая включает факторы роста (EGF) и факторы адгезии (FN), инфицирования первичных птичьих клеток вирусом, культивирование инфицированных клеток в безсывороточной среде до получения вирусного поколения. Также изобретение относится к композиции и ее применению, которая содержит вирус, полученный заявленным способом, и способу лечения или вакцинации животных, который включает введение указанной выше композиции.
UAA200502041A 2002-09-05 2003-09-01 Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных UA85543C2 (ru)

Applications Claiming Priority (1)

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DKPA200201302 2002-09-05

Publications (1)

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UA85543C2 true UA85543C2 (ru) 2009-02-10

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ID=31970216

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UAA200502041A UA85543C2 (ru) 2002-09-05 2003-09-01 Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных

Country Status (23)

Country Link
US (4) US7695939B2 (ru)
EP (1) EP1434858B2 (ru)
JP (2) JP2005537793A (ru)
KR (1) KR101044538B1 (ru)
CN (1) CN1692156B (ru)
AT (1) ATE393212T2 (ru)
AU (1) AU2003264144C1 (ru)
BR (1) BRPI0313559B8 (ru)
CA (1) CA2494379C (ru)
CY (1) CY1114598T1 (ru)
DE (1) DE60320520T3 (ru)
DK (1) DK1434858T4 (ru)
EA (1) EA009008B1 (ru)
ES (1) ES2305514T5 (ru)
HK (1) HK1080507B (ru)
MX (1) MXPA04012966A (ru)
NO (1) NO343489B1 (ru)
NZ (1) NZ538575A (ru)
PL (1) PL215169B1 (ru)
PT (1) PT1434858E (ru)
SI (1) SI1434858T2 (ru)
UA (1) UA85543C2 (ru)
WO (1) WO2004022729A1 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042480A2 (en) * 2000-11-23 2002-05-30 Bavarian Nordic A/S Modified vaccinia ankara virus variant
US7445924B2 (en) * 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
UA85543C2 (ru) 2002-09-05 2009-02-10 Бавариан Нордик А/С Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных
EP1528101A1 (en) 2003-11-03 2005-05-04 ProBioGen AG Immortalized avian cell lines for virus production
DK1855720T4 (da) 2005-02-23 2023-07-24 Bavarian Nordic As Anvendelse af et modificeret poxvirus til hurtig induktion af immunitet mod et poxvirus eller andre smitstoffer
FR2884255B1 (fr) 2005-04-11 2010-11-05 Vivalis Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe
ES2611975T3 (es) * 2006-06-20 2017-05-11 Transgene S.A. Procedimiento para producir poxvirus y composiciones de poxvirus
RU2012106760A (ru) * 2009-07-21 2013-08-27 Трансген Са Ферментативная композиция для ферментативного расщепления куриного эмбриона
US20130164329A1 (en) * 2010-02-17 2013-06-27 Alnylam Pharmaceuticals, Inc. Cell-based methods and reagents
JP2013523175A (ja) 2010-04-14 2013-06-17 イーエムディー・ミリポア・コーポレーション 高力価、高純度のウイルスストックの作製方法及びその使用方法
AU2011281982B2 (en) * 2010-07-20 2015-12-17 Bavarian Nordic A/S Method for harvesting expression products
KR101504159B1 (ko) * 2012-04-20 2015-03-19 한국생명공학연구원 미세조류의 성장을 촉진하는 엑소피아라 올리고스퍼마 및 이의 용도
SG11201609980TA (en) * 2014-06-18 2016-12-29 Medimmune Llc Cell culture methods and media comprising n-acetylcysteine
KR101677231B1 (ko) 2014-12-18 2016-11-30 제주대학교 산학협력단 무혈청배지（serum free medium）를 이용한 메갈로사이티바이러스의 효율적 제조방법
CN105462911B (zh) * 2015-12-22 2018-04-13 肇庆大华农生物药品有限公司 用于培养病毒的无血清培养液及其制备方法
CN107129963A (zh) * 2017-04-24 2017-09-05 浙江美保龙生物技术有限公司 一种df‑1细胞培养液添加剂及其制备方法、使用方法
KR102658198B1 (ko) 2017-05-15 2024-04-16 얀센 백신스 앤드 프리벤션 비.브이. 안정한 바이러스 함유 조성물
CA3061678A1 (en) 2017-05-15 2018-11-22 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
EP3833367A4 (en) * 2018-08-08 2022-05-11 Arizona Board of Regents on behalf of Arizona State University Method for improved poxvirus yields
CA3111273C (en) 2018-09-06 2024-03-26 Bavarian Nordic A/S Storage improved poxvirus compositions
BR112022017438A2 (pt) 2020-03-12 2022-10-18 Bavarian Nordic As Composições que melhoram a estabilidade do poxvírus
CN113355297A (zh) * 2021-06-23 2021-09-07 吉林冠界生物技术有限公司 一种灌流式培养全悬浮mdck细胞生产重组禽流感病毒的方法
CA3260357A1 (en) 2022-06-29 2024-01-04 Bavarian Nordic A/S RECOMBINANT MODIFIED ANKARA VIRUS (MVA) AND SMALL ACTIVATOR RNA (SPR) PRIMARY IMMUNIZATION REGIMEN
AU2023300396A1 (en) 2022-06-29 2025-01-09 Bavarian Nordic A/S Epstein-barr-virus vaccine
CN116656628A (zh) * 2023-07-31 2023-08-29 深圳市卫光生物制品股份有限公司 一种痘病毒载体疫苗的制备方法

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2004402A (en) * 1934-04-07 1935-06-11 Conklin John Edward Atomizer
US3887430A (en) * 1972-02-24 1975-06-03 Dow Chemical Co Culture medium for tissue culture techniques
US4072565A (en) * 1974-11-04 1978-02-07 The Dow Chemical Company Production of viruses in tissue culture without use of serum
US3914408A (en) * 1973-10-12 1975-10-21 Univ Nebraska Vaccine for neonatal calf diarrhea
DE2714665A1 (de) * 1977-04-01 1978-10-05 Mayr Anton Praeparat zur behandlung von herpes zoster und anderen herpes-infektionen, sowie verfahren zu seiner herstellung
US5833975A (en) * 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US5155020A (en) * 1989-03-08 1992-10-13 Health Research Inc. Recombinant poxvirus host range selection system
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
AU613583B2 (en) * 1986-08-22 1991-08-08 Transgene S.A. Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity
US5024947A (en) * 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby
CA1341245C (en) * 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Recombinant vaccinia virus mva
US6248333B1 (en) 1990-04-04 2001-06-19 Health Research Inc. Isolated nucleic acid sequence of equine herpesvirus type 1 glycoprotein D (EHV-1 gD)
AT393277B (de) * 1990-01-04 1991-09-25 Immuno Ag Verfahren zur herstellung von fruehsommer- meningoenzephalitis-virus (fsme-virus)-antigen
CA2091443A1 (en) * 1990-09-25 1992-03-26 Luciano Ramos Medium for culture of mammalian cells
US5766598A (en) 1991-03-07 1998-06-16 Virogenetics Corporation Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products
US5843456A (en) * 1991-03-07 1998-12-01 Virogenetics Corporation Alvac poxvirus-rabies compositions and combination compositions and uses
JP3602530B2 (ja) * 1991-03-07 2004-12-15 ヴァイロジェネティクス コーポレイション 遺伝子操作したワクチン菌株
IL102929A (en) 1992-08-24 1996-11-14 Interpharm Lab Ltd Serum-free medium for mammalian cells
US5403582A (en) * 1993-01-21 1995-04-04 Nippon Zeon Co., Ltd. Vaccine comprising fowlpox virus recombinants expressing the envelope glycoprotein of an avian reticuloendotheliosis retrovirus
US5405772A (en) 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US5768598A (en) 1993-09-13 1998-06-16 Intel Corporation Method and apparatus for sharing hardward resources in a computer system
US6015686A (en) * 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US6190655B1 (en) * 1993-12-03 2001-02-20 Immunex Corporation Methods of using Flt-3 ligand for exogenous gene transfer
DE4405841C1 (de) 1994-02-23 1995-01-05 Mayr Anton Prof Dr Med Vet Dr Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ATE298370T1 (de) * 1994-04-29 2005-07-15 Baxter Healthcare Sa Rekombinante poxviren mit fremdenpolynukleotiden in wichtigen regionen
US5753489A (en) * 1994-11-10 1998-05-19 Immuno Ag Method for producing viruses and vaccines in serum-free culture
US6146873A (en) * 1994-11-10 2000-11-14 Baxter Aktiengesellschaft Production of orthomyxoviruses in monkey kidney cells using protein-free media
US5756341A (en) * 1994-11-10 1998-05-26 Immuno Ag Method for controlling the infectivity of viruses
EP0791055B1 (en) 1994-11-10 2012-01-25 Baxter Healthcare S.A. Method for producing biologicals in protein-free culture
US5503582A (en) 1994-11-18 1996-04-02 Micron Display Technology, Inc. Method for forming spacers for display devices employing reduced pressures
UA68327C2 (en) 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
JPH09154571A (ja) * 1995-12-05 1997-06-17 Kurabo Ind Ltd ウイルス製造用無血清培地
WO1997031119A1 (en) 1996-02-21 1997-08-28 Res Inst For Genetic And Human Methods and compositions for protective and therapeutic genetic immunization
WO1998004680A1 (en) 1996-07-26 1998-02-05 University Of Manitoba Serum-free medium for growth of anchorage-dependant mammalian cells
US6869793B2 (en) 1996-09-24 2005-03-22 Bavarian Nordic Research Institute Recombinant MVA virus expressing dengue virus antigens, and the use thereof in vaccines
EP1983044B1 (en) 1996-10-10 2016-08-10 Life Technologies Corporation Animal cell culture media comprising plant-derived nutrients
AU5091898A (en) 1996-10-25 1998-05-15 Wistar Institute Of Anatomy And Biology, The Method of vaccinating infants against infections
US6204250B1 (en) * 1996-11-22 2001-03-20 The Mount Sinai Medical Center Of The City Of New York Immunization of infants
US20030138454A1 (en) * 1997-06-09 2003-07-24 Oxxon Pharmaccines, Ltd. Vaccination method
GB9711957D0 (en) 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
GB0023203D0 (en) 2000-09-21 2000-11-01 Isis Innovation Vaccination method
AT407255B (de) * 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
WO1999007869A1 (en) 1997-08-05 1999-02-18 University Of Florida Live recombinant vaccine comprising inefficiently or non-replicating virus
EP1019513A1 (en) * 1998-08-04 2000-07-19 Immunex Corporation Ikr-1 and ikr-2, protein kinases which are related to the i kappa b kinases
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
WO2000028016A1 (en) 1998-11-10 2000-05-18 University Of Rochester T cells specific for target antigens and methods and vaccines based thereon
GB2370571B (en) 1998-11-18 2003-05-07 Oxford Biomedica Ltd A modified 5t4 antigen
CA2351622A1 (en) 1998-11-18 2000-05-25 Oxford Biomedica (Uk) Limited Polypeptide
US6497883B1 (en) * 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
DE19935351A1 (de) 1999-07-29 2001-02-01 Abb Daimler Benz Transp Verfahren zur Energieoptimierung bei einem Fahrzeug/Zug mit arbeitspunktabhängigem Wirkungsgrad
MXPA02008873A (es) 2000-03-14 2003-02-10 Anton Mayr Cepa alterada del virus de vaccinia ankara modificado (mva).
AU2001256582A1 (en) 2000-05-24 2001-12-03 Merial Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
CA2415397C (en) * 2000-07-11 2011-04-26 Bayer Aktiengesellschaft Use of strains of parapoxvirus ovis for producing antiviral medicaments and medicaments against cancer
KR20030061810A (ko) * 2000-09-25 2003-07-22 폴리문 사이언티픽 임무노이비오로기쉐 포르슝 게엠베하 생균 백신과 제조 방법
WO2002042480A2 (en) * 2000-11-23 2002-05-30 Bavarian Nordic A/S Modified vaccinia ankara virus variant
US7097842B2 (en) * 2000-11-23 2006-08-29 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7445924B2 (en) * 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
UA82466C2 (ru) * 2001-07-18 2008-04-25 Бавариан Нордика А/С Способ усиления амплификации хордопоксвируса
JP4500049B2 (ja) * 2001-12-04 2010-07-14 バヴァリアン・ノルディック・アクティーゼルスカブ フラビウイルスｎｓ１サブユニットワクチン
US6951752B2 (en) 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
NZ533302A (en) 2001-12-10 2005-11-25 Bavarian Nordic As Poxvirus containing formulations and process for preparing stable, poxvirus containing compositions containing a disaaccharide and a pharmaceutically acceptable polymer i.e. dextran or polyvinylpyrrolidon (PVP)
EP1407006B9 (en) 2001-12-20 2006-10-18 Bavarian Nordic A/S Method for the recovery and purification of poxviruses from infected cells
FR2836924B1 (fr) 2002-03-08 2005-01-14 Vivalis Lignees de cellules aviaires utiles pour la production de substances d'interet
WO2003078640A2 (en) * 2002-03-15 2003-09-25 Baxter International Inc. Recombinant drug-sensitive vaccinia virus as smallpox vaccine
KR101138067B1 (ko) * 2002-05-16 2012-04-24 버베리안 노딕 에이/에스 수두 바이러스 게놈내로 삽입된 상동 유전자를 발현하는 재조합 수두 바이러스
BR0310020A (pt) * 2002-05-16 2005-02-15 Bavarian Nordic As Expressão de genes no vìrus da vacìnia modificado ancara por uso do promotor de ati de vacìnia
UA85543C2 (ru) 2002-09-05 2009-02-10 Бавариан Нордик А/С Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных
CA2531565C (en) 2003-07-22 2014-02-11 Vivalis Production of poxviruses with adherent or non adherent avian cell lines
US6915752B2 (en) * 2003-09-30 2005-07-12 Lockheed Martin Corporation Utility service protection strip
US6976752B2 (en) * 2003-10-28 2005-12-20 Lexmark International, Inc. Ink jet printer with resistance compensation circuit

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