JP2008502366A5 - - Google Patents
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- Publication number
- JP2008502366A5 JP2008502366A5 JP2007527694A JP2007527694A JP2008502366A5 JP 2008502366 A5 JP2008502366 A5 JP 2008502366A5 JP 2007527694 A JP2007527694 A JP 2007527694A JP 2007527694 A JP2007527694 A JP 2007527694A JP 2008502366 A5 JP2008502366 A5 JP 2008502366A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- antigen
- binding fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 72
- 239000000427 antigen Substances 0.000 claims 66
- 102000036639 antigens Human genes 0.000 claims 66
- 108091007433 antigens Proteins 0.000 claims 66
- 125000003275 alpha amino acid group Chemical group 0.000 claims 47
- 108090000176 Interleukin-13 Proteins 0.000 claims 32
- 102000003816 Interleukin-13 Human genes 0.000 claims 32
- 108060003951 Immunoglobulin Proteins 0.000 claims 22
- 102000018358 immunoglobulin Human genes 0.000 claims 22
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 16
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 235000001014 amino acid Nutrition 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000035475 disorder Diseases 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 101001076430 Homo sapiens Interleukin-13 Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 6
- 102000019207 human interleukin-13 Human genes 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 208000006673 asthma Diseases 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 210000004602 germ cell Anatomy 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- 208000012657 Atopic disease Diseases 0.000 claims 3
- 102100020791 Interleukin-13 receptor subunit alpha-1 Human genes 0.000 claims 3
- 101710112663 Interleukin-13 receptor subunit alpha-1 Proteins 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 208000037883 airway inflammation Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000001681 protective effect Effects 0.000 claims 3
- 241000244186 Ascaris Species 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000008859 change Effects 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 2
- 230000003843 mucus production Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 102100023688 Eotaxin Human genes 0.000 claims 1
- 101710139422 Eotaxin Proteins 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 1
- 108010073816 IgE Receptors Proteins 0.000 claims 1
- 102000009438 IgE Receptors Human genes 0.000 claims 1
- 102000012745 Immunoglobulin Subunits Human genes 0.000 claims 1
- 108010079585 Immunoglobulin Subunits Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 208000037656 Respiratory Sounds Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 102000013968 STAT6 Transcription Factor Human genes 0.000 claims 1
- 108010011005 STAT6 Transcription Factor Proteins 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 206010047924 Wheezing Diseases 0.000 claims 1
- 230000036428 airway hyperreactivity Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000001078 anti-cholinergic effect Effects 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 230000005784 autoimmunity Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 229940125388 beta agonist Drugs 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 230000007885 bronchoconstriction Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- 230000003915 cell function Effects 0.000 claims 1
- 230000009918 complex formation Effects 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000004941 influx Effects 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 229940065725 leukotriene receptor antagonists for obstructive airway diseases Drugs 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 230000017128 negative regulation of NF-kappaB transcription factor activity Effects 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57847304P | 2004-06-09 | 2004-06-09 | |
| US57873604P | 2004-06-09 | 2004-06-09 | |
| US60/578,473 | 2004-06-09 | ||
| US60/578,736 | 2004-06-09 | ||
| US58137504P | 2004-06-22 | 2004-06-22 | |
| US60/581,375 | 2004-06-22 | ||
| PCT/US2005/020160 WO2005123126A2 (en) | 2004-06-09 | 2005-06-09 | Antibodies against human interleukin-13 and uses therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011051866A Division JP2011155980A (ja) | 2004-06-09 | 2011-03-09 | ヒトインターロイキン−１３に対する抗体およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008502366A JP2008502366A (ja) | 2008-01-31 |
| JP2008502366A5 true JP2008502366A5 (enExample) | 2011-04-21 |
| JP4970258B2 JP4970258B2 (ja) | 2012-07-04 |
Family
ID=35503715
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527730A Withdrawn JP2008515776A (ja) | 2004-06-09 | 2005-06-09 | 抗ｉｌ−１３抗体、抗ｉｌ−１３抗体の結晶および該抗体を含有する複合体 |
| JP2007527694A Expired - Fee Related JP4970258B2 (ja) | 2004-06-09 | 2005-06-09 | ヒトインターロイキン−１３に対する抗体およびそれらの使用 |
| JP2011051866A Pending JP2011155980A (ja) | 2004-06-09 | 2011-03-09 | ヒトインターロイキン−１３に対する抗体およびそれらの使用 |
| JP2014167064A Pending JP2015037401A (ja) | 2004-06-09 | 2014-08-20 | ヒトインターロイキン−１３に対する抗体およびそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527730A Withdrawn JP2008515776A (ja) | 2004-06-09 | 2005-06-09 | 抗ｉｌ−１３抗体、抗ｉｌ−１３抗体の結晶および該抗体を含有する複合体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011051866A Pending JP2011155980A (ja) | 2004-06-09 | 2011-03-09 | ヒトインターロイキン−１３に対する抗体およびそれらの使用 |
| JP2014167064A Pending JP2015037401A (ja) | 2004-06-09 | 2014-08-20 | ヒトインターロイキン−１３に対する抗体およびそれらの使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7615213B2 (enExample) |
| EP (3) | EP2548889A1 (enExample) |
| JP (4) | JP2008515776A (enExample) |
| KR (3) | KR101462878B1 (enExample) |
| CN (2) | CN101141980B (enExample) |
| AR (2) | AR049390A1 (enExample) |
| AU (2) | AU2005253981B2 (enExample) |
| BR (2) | BRPI0510881A (enExample) |
| CA (2) | CA2567081A1 (enExample) |
| CR (2) | CR8783A (enExample) |
| EC (2) | ECSP067072A (enExample) |
| IL (2) | IL179093A0 (enExample) |
| MX (2) | MXPA06014298A (enExample) |
| NO (2) | NO20070087L (enExample) |
| NZ (1) | NZ582046A (enExample) |
| RU (2) | RU2006140096A (enExample) |
| SG (2) | SG135207A1 (enExample) |
| TW (1) | TWI391133B (enExample) |
| WO (2) | WO2005121177A2 (enExample) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| US7883704B2 (en) | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
| EP1444989A1 (en) * | 2003-02-07 | 2004-08-11 | Giorgio Dr. Stassi | Sensitizing cells for apoptosis by selectively blocking cytokines |
| EP2805728B1 (en) * | 2003-12-23 | 2020-02-05 | Genentech, Inc. | Novel anti-IL 13 antibodies and uses thereof |
| US7501121B2 (en) | 2004-06-17 | 2009-03-10 | Wyeth | IL-13 binding agents |
| AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
| US20090098142A1 (en) * | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
| TWI307630B (en) * | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| ATE492563T1 (de) * | 2004-11-17 | 2011-01-15 | Amgen Inc | Vollständige humane monoklonale antikörper gegen il-13 |
| EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| EP1877074B1 (en) * | 2005-04-15 | 2013-03-27 | The Government of the United States of America, as represented by the Secretary of Health and Human Services | Treatment and prevention of inflammatory bowel disease involving il-13 and nkt cells |
| JP2009510046A (ja) | 2005-09-30 | 2009-03-12 | メドイミューン・リミテッド | インターロイキン−１３抗体組成物 |
| US20070237763A1 (en) * | 2005-10-06 | 2007-10-11 | Baylor Research Institute | Compositions and methods for the treatment of cancer |
| US20070202106A1 (en) * | 2005-10-06 | 2007-08-30 | Baylor Research Institute | Compositions and methods for the treatment of cancer |
| JP5006330B2 (ja) * | 2005-10-21 | 2012-08-22 | ノバルティス アーゲー | Ｉｌ１３に対するヒト抗体および治療的使用 |
| PL1976877T5 (pl) | 2005-11-30 | 2017-09-29 | Abbvie Inc | Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania |
| BRPI0620316A2 (pt) | 2005-12-21 | 2011-11-08 | Wyeth Corp | formulações de proteìnas com viscosidades reduzida e seus usos |
| WO2007085815A2 (en) * | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind il-4 and/or il-13 |
| CN103073639A (zh) | 2006-03-17 | 2013-05-01 | 比奥根艾迪克Ma公司 | 稳定的多肽组合物 |
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| ES2654040T3 (es) | 2006-03-31 | 2018-02-12 | Chugai Seiyaku Kabushiki Kaisha | Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos |
| BRPI0713484A2 (pt) * | 2006-06-21 | 2012-11-06 | Apogenix Gmbh | expressão diferencial de citocina em cáncer humano |
| AU2007271349A1 (en) * | 2006-07-06 | 2008-01-10 | Apogenix Gmbh | Human IL-4 muteins in combination with chemotherapeutics or pro-apoptotic agents in cancer therapy |
| PE20080913A1 (es) * | 2006-09-08 | 2008-08-21 | Wyeth Corp | Lavado de arginina en la purificacion de proteinas usando cromatografia de afinidad |
| KR101625961B1 (ko) * | 2006-09-08 | 2016-05-31 | 애브비 바하마스 리미티드 | 인터루킨-13 결합 단백질 |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| AU2007308145A1 (en) * | 2006-10-12 | 2008-04-17 | Wyeth | Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| NZ576133A (en) | 2006-10-27 | 2012-10-26 | Abbott Biotech Ltd | Crystalline anti-htnfalpha antibodies |
| JP2010512402A (ja) * | 2006-12-11 | 2010-04-22 | ワイス エルエルシー | Ｉｌ−１３関連障害を治療するための方法および組成物ならびにその治療をモニター観察するための方法 |
| JP5419709B2 (ja) * | 2007-01-09 | 2014-02-19 | ワイス・エルエルシー | 抗ｉｌ−１３抗体製剤およびその使用 |
| RU2475265C2 (ru) | 2007-01-16 | 2013-02-20 | Эбботт Лэборетриз | Способы лечения псориаза |
| MX2009009080A (es) | 2007-02-23 | 2009-11-02 | Schering Corp | Anticuerpos anti-interleucina-23p19 manipulados por ingenieria genetica. |
| RS58098B1 (sr) | 2007-02-23 | 2019-02-28 | Merck Sharp & Dohme | Anti-il-23p19 antitela proizvedena genetičkim inženjerstvom |
| MX2009010361A (es) * | 2007-03-29 | 2009-10-16 | Abbott Lab | Anticuerpos il-12 anti-humanos cristalinos. |
| WO2008131376A2 (en) * | 2007-04-23 | 2008-10-30 | Wyeth | Methods and compositions for treating and monitoring treatment of il-13-associated disorders |
| US7890055B1 (en) * | 2007-07-09 | 2011-02-15 | Everlokt Corporation | Touch field compound field detector personal ID |
| US8753839B2 (en) | 2007-08-08 | 2014-06-17 | Abbvie Inc. | Compositions and methods for crystallizing antibodies |
| MX369784B (es) | 2007-09-26 | 2019-11-21 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| JP2009106163A (ja) * | 2007-10-26 | 2009-05-21 | Kyushu Univ | 核酸配列、ベクター、形質転換体、製造方法、及び、核酸配列プライマー |
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