JP2007530441A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007530441A5 JP2007530441A5 JP2006533000A JP2006533000A JP2007530441A5 JP 2007530441 A5 JP2007530441 A5 JP 2007530441A5 JP 2006533000 A JP2006533000 A JP 2006533000A JP 2006533000 A JP2006533000 A JP 2006533000A JP 2007530441 A5 JP2007530441 A5 JP 2007530441A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- peg
- daltons
- molecular weight
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 239000000539 dimer Substances 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 102100016635 EPOR Human genes 0.000 claims 2
- 108010075944 Erythropoietin Receptors Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- IYKLZBIWFXPUCS-VIFPVBQESA-N (2S)-2-(naphthalen-1-ylamino)propanoic acid Chemical compound C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 claims 1
- OKJIRPAQVSHGFK-UHFFFAOYSA-N Aceturic acid Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
Claims (4)
- エリスロポエチン受容体（EPO-R）に結合し、活性化する化合物であって、
該化合物は、式：
ここで、(i) 該ペプチドダイマーのそれぞれのペプチドモノマーにおいて、それぞれのア
ミノ酸は標準の一文字略号により示され、AcGはN-アセチルグリシンおよび1-nalは1-ナフ
チルアラニンであり；
(ii) 該ペプチドダイマーのそれぞれのペプチドモノマーは、それぞれのモノマーの2個の
システイン（C）残基の間に分子内ジスルフィド結合を含み；
(iii) PEGは、合わせた分子量10,000〜30,000ダルトンを有する2個の直鎖状のポリエ
チレングリコール（PEG）部分を含有する；
前記化合物。 - それぞれのPEGが分子量20,000ダルトンを有する、請求項１記載の化合物。
- 請求項１の化合物および薬学的に許容されうるキャリアを含有する医薬組成物。
- それぞれのPEGが分子量20,000ダルトンを有する、請求項３記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46999303P | 2003-05-12 | 2003-05-12 | |
| US47024403P | 2003-05-12 | 2003-05-12 | |
| PCT/US2004/014889 WO2004101606A2 (en) | 2003-05-12 | 2004-05-12 | Novel peptides that bind to the erythropoietin receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008278252A Division JP4768795B2 (ja) | 2003-05-12 | 2008-10-29 | エリスロポエチン受容体に結合する新規ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007530441A JP2007530441A (ja) | 2007-11-01 |
| JP2007530441A5 true JP2007530441A5 (ja) | 2008-12-18 |
| JP4266028B2 JP4266028B2 (ja) | 2009-05-20 |
Family
ID=33457168
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533000A Expired - Fee Related JP4266028B2 (ja) | 2003-05-12 | 2004-05-12 | エリスロポエチン受容体に結合する新規ペプチド |
| JP2008278252A Expired - Fee Related JP4768795B2 (ja) | 2003-05-12 | 2008-10-29 | エリスロポエチン受容体に結合する新規ペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008278252A Expired - Fee Related JP4768795B2 (ja) | 2003-05-12 | 2008-10-29 | エリスロポエチン受容体に結合する新規ペプチド |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US7084245B2 (ja) |
| EP (1) | EP1629007B1 (ja) |
| JP (2) | JP4266028B2 (ja) |
| KR (1) | KR101163683B1 (ja) |
| CN (1) | CN100441595C (ja) |
| AP (1) | AP2042A (ja) |
| AT (1) | ATE428727T1 (ja) |
| AU (1) | AU2004238870B8 (ja) |
| BR (1) | BRPI0411155A (ja) |
| CA (1) | CA2525568C (ja) |
| CR (1) | CR8131A (ja) |
| CY (1) | CY1109028T1 (ja) |
| DE (1) | DE602004020610D1 (ja) |
| DK (1) | DK1629007T3 (ja) |
| EA (1) | EA010095B1 (ja) |
| ES (1) | ES2323465T3 (ja) |
| HK (1) | HK1088616A1 (ja) |
| HR (1) | HRP20090251T1 (ja) |
| IL (1) | IL171782A (ja) |
| IS (1) | IS2683B (ja) |
| ME (1) | MEP53308A (ja) |
| MX (1) | MXPA05012316A (ja) |
| NO (1) | NO338435B1 (ja) |
| NZ (1) | NZ543905A (ja) |
| OA (1) | OA13164A (ja) |
| PL (1) | PL1629007T3 (ja) |
| PT (1) | PT1629007E (ja) |
| RS (1) | RS51130B (ja) |
| SG (1) | SG160224A1 (ja) |
| SI (1) | SI1629007T1 (ja) |
| UA (1) | UA88146C2 (ja) |
| WO (1) | WO2004101606A2 (ja) |
| ZA (1) | ZA200510010B (ja) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7259146B2 (en) | 2000-05-26 | 2007-08-21 | Ortho-Mcneil Pharmaceutical, Inc. | Neuroprotective peptides |
| KR101163683B1 (ko) | 2003-05-12 | 2012-07-10 | 아피맥스, 인크. | 에리스로포이에틴 수용체에 결합하는 신규의 펩티드 |
| PT1625156E (pt) * | 2003-05-12 | 2013-01-09 | Affymax Inc | Novos péptidos que se fixam ao receptor da eritropoietina |
| KR20060028675A (ko) * | 2003-05-12 | 2006-03-31 | 아피맥스, 인크. | 신규한 폴리 (에틸렌 글리콜) 개질 화합물 및 그의 용도 |
| CN1849141A (zh) * | 2003-05-12 | 2006-10-18 | 阿费麦克斯公司 | 用于聚(乙二醇)修饰的肽的间隔臂部分 |
| ES2431314T3 (es) | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
| DE102004031258A1 (de) * | 2004-06-29 | 2006-02-09 | Jennissen, Herbert P., Prof. Dr. | Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen |
| US7589063B2 (en) | 2004-12-14 | 2009-09-15 | Aplagen Gmbh | Molecules which promote hematopoiesis |
| AU2005310189A1 (en) * | 2004-11-11 | 2006-06-08 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US7919461B2 (en) * | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| GB0523954D0 (en) * | 2005-11-24 | 2006-01-04 | Ucb Celltech | Bioassays |
| US20080090760A2 (en) * | 2005-12-09 | 2008-04-17 | Todd Hembrough | Compositions and Methods for Inhibiting Cellular Proliferation |
| CN101528263B (zh) | 2006-06-30 | 2013-01-23 | Sku资产管理有限公司 | 用于癌症的先天性免疫方法的缀合物 |
| WO2008057537A2 (en) | 2006-11-08 | 2008-05-15 | Maine Medical Center Research | System and method for identifying erythropoietin-responsive genes |
| EP2120998B1 (en) | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
| JP2010520855A (ja) * | 2007-01-31 | 2010-06-17 | アフィーマックス・インコーポレイテッド | 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー |
| PE20130588A1 (es) | 2007-02-02 | 2013-05-21 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
| WO2009002947A2 (en) * | 2007-06-22 | 2008-12-31 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| EP2018835B1 (de) | 2007-07-09 | 2014-03-05 | Augustinus Bader | Wirkstoff abgebendes Pflaster |
| WO2009025958A1 (en) * | 2007-08-22 | 2009-02-26 | Affymax, Inc. | Erythropoietin rceptor peptide formulations and uses |
| ES2750254T3 (es) | 2007-09-27 | 2020-03-25 | Amgen Inc | Formulaciones farmacéuticas |
| EP2219602A1 (en) | 2007-11-15 | 2010-08-25 | Amgen, Inc | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
| CN101456911A (zh) * | 2007-12-12 | 2009-06-17 | 江苏豪森药业股份有限公司 | 促红细胞生成素模拟肽衍生物及其可药用盐和其制备方法与用途 |
| US20100266591A1 (en) * | 2008-01-07 | 2010-10-21 | Peter Bugelski | Method of treating erythropoietin hyporesponsive anemias |
| ES2539124T3 (es) | 2008-01-22 | 2015-06-26 | Araim Pharmaceuticals, Inc. | Péptidos y análogos peptídicos protectores de tejido para la prevención y el tratamiento de enfermedades y trastornos asociados con daño tisular |
| EP2803675A3 (en) | 2008-01-25 | 2014-12-24 | Amgen, Inc | Ferroportin antibodies and methods of use |
| JP2009191056A (ja) * | 2008-02-15 | 2009-08-27 | Affymax Inc | 合成ペプチドをベースとするｅｐｏレセプターアゴニストを用いた抗エリスロポエチン抗体に媒介された障害の治療 |
| AU2009246946B2 (en) | 2008-05-01 | 2013-09-26 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| US8318167B2 (en) | 2008-11-13 | 2012-11-27 | The General Hospital Corporation | Methods and compositions for regulating iron homeostasis by modulation of BMP-6 |
| WO2011012306A2 (en) | 2009-07-30 | 2011-02-03 | Aplagen Gmbh | Use of emps for antagonising epo-stimulatory effects on epo-responsive tumors while maintaining erythropoiesis |
| WO2011050333A1 (en) | 2009-10-23 | 2011-04-28 | Amgen Inc. | Vial adapter and system |
| FI2575935T4 (fi) | 2010-06-07 | 2023-11-23 | Amgen Inc | Lääkeaineen vapautuslaite |
| DK2590666T3 (en) | 2010-07-06 | 2017-07-17 | Augustinus Bader | TOPICAL APPLICATION OF ERYTHROPOIETIN FOR USE IN THE TREATMENT OF DAMAGE OF THE CORNS |
| EP2471945A1 (de) * | 2010-12-30 | 2012-07-04 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur Bestimmung von Inhibitoren der Gerinnung |
| EP2691065B1 (en) | 2011-03-31 | 2017-03-01 | Amgen Inc. | Vial adapter and system |
| CA2833748C (en) | 2011-04-20 | 2019-07-16 | Amgen Inc. | Autoinjector apparatus |
| US9422338B2 (en) * | 2011-05-19 | 2016-08-23 | Epodose Llc | Compounds that bind to the erythropoietin receptor |
| BR112014008993B1 (pt) | 2011-10-14 | 2021-06-08 | Amgen Inc | injetor e método de montagem |
| CA2884887C (en) | 2012-11-21 | 2023-09-12 | Amgen Inc. | Drug delivery device including insertion member and reservoir |
| CN105263514B (zh) | 2013-03-15 | 2019-04-26 | 本质生命科学有限公司 | 抗铁调素抗体及其用途 |
| JP6336564B2 (ja) | 2013-03-15 | 2018-06-06 | アムゲン・インコーポレーテッド | 薬物カセット、自動注入器、および自動注入器システム |
| TWI580452B (zh) | 2013-03-15 | 2017-05-01 | 安美基公司 | 用於注射器之匣盒、注射器及使用包括自動注射器及匣盒之設備之方法 |
| SG11201507878SA (en) | 2013-03-22 | 2015-10-29 | Amgen Inc | Injector and method of assembly |
| CN104231067B (zh) * | 2013-06-07 | 2017-08-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 促红细胞生成素模拟肽化学二聚体及其用途 |
| WO2015061386A1 (en) | 2013-10-24 | 2015-04-30 | Amgen Inc. | Injector and method of assembly |
| EP3060281B1 (en) | 2013-10-24 | 2019-01-30 | Amgen Inc. | Drug delivery system with temperature-sensitive control |
| US10994112B2 (en) | 2014-02-05 | 2021-05-04 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
| EP3785749A1 (en) | 2014-05-07 | 2021-03-03 | Amgen Inc. | Autoinjector with shock reducing elements |
| WO2015187797A1 (en) | 2014-06-03 | 2015-12-10 | Amgen Inc. | Controllable drug delivery system and method of use |
| CA2961917A1 (en) | 2014-09-22 | 2016-03-31 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| US10695506B2 (en) | 2014-10-14 | 2020-06-30 | Amgen Inc. | Drug injection device with visual and audio indicators |
| EP3689394A1 (en) | 2014-12-19 | 2020-08-05 | Amgen Inc. | Drug delivery device with live button or user interface field |
| ES2898469T3 (es) | 2014-12-19 | 2022-03-07 | Amgen Inc | Dispositivo de administración de medicamentos con sensor de proximidad |
| WO2016133947A1 (en) | 2015-02-17 | 2016-08-25 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
| WO2016138434A1 (en) | 2015-02-27 | 2016-09-01 | Amgen Inc. | Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement |
| WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
| CN106554394B (zh) * | 2015-09-30 | 2019-08-16 | 天津药物研究院有限公司 | 一种促红细胞生成素模拟肽及其制备方法和应用 |
| US10138273B2 (en) * | 2015-10-07 | 2018-11-27 | The Curators Of The University Of Missouri | Peptide ligands for hepatic stellate cells |
| JP7082568B2 (ja) | 2015-12-09 | 2022-06-08 | アムジエン・インコーポレーテツド | 信号伝達キャップ付き自動注射器 |
| US11154661B2 (en) | 2016-01-06 | 2021-10-26 | Amgen Inc. | Auto-injector with signaling electronics |
| ES2814287T3 (es) | 2016-03-15 | 2021-03-26 | Amgen Inc | Reducir la probabilidad de rotura de cristal en dispositivos de administración de fármaco |
| US11541168B2 (en) | 2016-04-29 | 2023-01-03 | Amgen Inc. | Drug delivery device with messaging label |
| US11389588B2 (en) | 2016-05-02 | 2022-07-19 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
| GB2550114A (en) * | 2016-05-03 | 2017-11-15 | Kymab Ltd | Methods, regimens, combinations & antagonists |
| EP3455142B1 (en) | 2016-05-13 | 2023-08-09 | Amgen Inc. | Vial sleeve assembly |
| EP3458988B1 (en) | 2016-05-16 | 2023-10-18 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
| GB201609083D0 (en) | 2016-05-24 | 2016-07-06 | Syntab Therapeutics Gmbh | Synthetic compound |
| US11541176B2 (en) | 2016-06-03 | 2023-01-03 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
| EP3478342A1 (en) | 2016-07-01 | 2019-05-08 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
| US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
| WO2018081234A1 (en) | 2016-10-25 | 2018-05-03 | Amgen Inc. | On-body injector |
| AU2018210301A1 (en) | 2017-01-17 | 2019-08-01 | Amgen Inc. | Injection devices and related methods of use and assembly |
| MX2019009625A (es) | 2017-02-17 | 2019-10-09 | Amgen Inc | Dispositivo de administracion de farmacos con trayectoria de flujo de fluido esteril y metodo relacionado de ensamblaje. |
| JP7280189B2 (ja) | 2017-02-17 | 2023-05-23 | アムジエン・インコーポレーテツド | 薬物送達装置用の挿入機構 |
| MX2019010544A (es) | 2017-03-06 | 2019-10-21 | Amgen Inc | Dispositivo de administracion de farmacos con caracteristica de prevencion de la activacion. |
| SG11201908058UA (en) | 2017-03-07 | 2019-09-27 | Amgen Inc | Needle insertion by overpressure |
| MX2019010671A (es) | 2017-03-09 | 2019-10-21 | Amgen Inc | Mecanismo de insercion para dispositivo de administracion de farmacos. |
| WO2018172219A1 (en) | 2017-03-20 | 2018-09-27 | F. Hoffmann-La Roche Ag | Method for in vitro glycoengineering of an erythropoiesis stimulating protein |
| EP3600491B1 (en) | 2017-03-28 | 2023-08-09 | Amgen Inc. | Plunger rod and syringe assembly system and method |
| AU2018280054B2 (en) | 2017-06-08 | 2023-07-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
| MX2019014615A (es) | 2017-06-08 | 2020-02-07 | Amgen Inc | Dispositivo de administracion de farmacos accionado por par de torsion. |
| JP7195276B2 (ja) | 2017-06-22 | 2022-12-23 | アムジエン・インコーポレーテツド | デバイス起動による衝突／衝撃の低減 |
| WO2018237225A1 (en) | 2017-06-23 | 2018-12-27 | Amgen Inc. | ELECTRONIC DRUG DELIVERY DEVICE COMPRISING A CAP ACTIVATED BY A SWITCH ASSEMBLY |
| ES2972207T3 (es) | 2017-07-14 | 2024-06-11 | Amgen Inc | Sistema de inserción-retracción de agujas con sistema de resorte de torsión doble |
| IL271173B2 (en) | 2017-07-21 | 2024-04-01 | Amgen Inc | Gas permeable sealing element for drug container and methods of assembly |
| MA49677A (fr) | 2017-07-25 | 2021-04-21 | Amgen Inc | Dispositif d'administration de médicament avec module d'engrenage et procédé d'assemblage associé |
| JP7242562B2 (ja) | 2017-07-25 | 2023-03-20 | アムジエン・インコーポレーテツド | 容器アクセスシステムを有する薬物送達デバイス及び関連する組立方法 |
| EP3664863A2 (en) | 2017-08-09 | 2020-06-17 | Amgen Inc. | Hydraulic-pneumatic pressurized chamber drug delivery system |
| EP3668567A1 (en) | 2017-08-18 | 2020-06-24 | Amgen Inc. | Wearable injector with sterile adhesive patch |
| US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
| US11759565B2 (en) | 2017-10-04 | 2023-09-19 | Amgen Inc. | Flow adapter for drug delivery device |
| EP3691716B1 (en) | 2017-10-06 | 2023-11-29 | Amgen Inc. | Drug delivery device with interlock assembly and related method of assembly |
| WO2019074579A1 (en) | 2017-10-09 | 2019-04-18 | Amgen Inc. | DRUG DELIVERY DEVICE COMPRISING A DRIVE ASSEMBLY AND ASSEMBLY METHOD THEREOF |
| EP3703779A1 (en) | 2017-11-03 | 2020-09-09 | Amgen Inc. | Systems and approaches for sterilizing a drug delivery device |
| JP2021501616A (ja) | 2017-11-06 | 2021-01-21 | アムジエン・インコーポレーテツド | 配置及び流量検出を備える薬物送達デバイス |
| WO2019090303A1 (en) | 2017-11-06 | 2019-05-09 | Amgen Inc. | Fill-finish assemblies and related methods |
| CN116832271A (zh) | 2017-11-10 | 2023-10-03 | 安进公司 | 用于药物递送装置的柱塞 |
| AU2018368340B2 (en) | 2017-11-16 | 2024-03-07 | Amgen Inc. | Door latch mechanism for drug delivery device |
| EP3710089A1 (en) | 2017-11-16 | 2020-09-23 | Amgen Inc. | Autoinjector with stall and end point detection |
| US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
| US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
| US20210260279A1 (en) | 2018-07-24 | 2021-08-26 | Amgen Inc. | Hybrid drug delivery devices with optional grip portion and related method of preparation |
| WO2020023336A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
| MX2021000748A (es) | 2018-07-24 | 2021-03-26 | Amgen Inc | Dispositivos de suministro para administrar farmacos. |
| EP3826699A1 (en) | 2018-07-24 | 2021-06-02 | Amgen Inc. | Delivery devices for administering drugs |
| CA3103105A1 (en) | 2018-07-31 | 2020-02-06 | Amgen Inc. | Fluid path assembly for a drug delivery device |
| CA3106452A1 (en) | 2018-09-24 | 2020-04-02 | Amgen Inc. | Interventional dosing systems and methods |
| IL281469B1 (en) | 2018-09-28 | 2024-04-01 | Amgen Inc | Assembling a memory alloy ejector activation assembly for a drug delivery device |
| TW202027806A (zh) | 2018-10-02 | 2020-08-01 | 美商安進公司 | 具有內部力傳遞的用於藥物遞送之注射系統 |
| AR116607A1 (es) | 2018-10-05 | 2021-05-26 | Amgen Inc | Dispositivo de administración de fármacos con indicador de dosis |
| MA53913A (fr) | 2018-10-15 | 2022-01-19 | Amgen Inc | Procédé d'assemblage de plate-forme pour dispositif d'administration de médicament |
| CN112789073B (zh) | 2018-10-15 | 2023-09-15 | 安进公司 | 具有阻尼机构的药物递送装置 |
| TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
| US20220031939A1 (en) | 2018-11-01 | 2022-02-03 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| WO2020091956A1 (en) | 2018-11-01 | 2020-05-07 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| JP7510952B2 (ja) | 2019-04-24 | 2024-07-04 | アムジエン・インコーポレーテツド | シリンジ滅菌確認アセンブリ及び方法 |
| JP2022545227A (ja) | 2019-08-23 | 2022-10-26 | アムジエン・インコーポレーテツド | 構成可能な針シールド係合構成要素を備えた薬物送達デバイス及び関連方法 |
| WO2022159414A1 (en) | 2021-01-22 | 2022-07-28 | University Of Rochester | Erythropoietin for gastroinfestinal dysfunction |
| KR20240011135A (ko) | 2021-05-21 | 2024-01-25 | 암젠 인크 | 약물 용기를 위한 충전 레시피를 최적화하는 방법 |
| WO2023209074A1 (en) | 2022-04-28 | 2023-11-02 | Institut National de la Santé et de la Recherche Médicale | Methods of restoring erythropoiesis in patients suffering from a sf3b1 mutant myelodysplastic syndrome by correcting coasy mis-splicing |
| WO2024094457A1 (en) | 2022-11-02 | 2024-05-10 | F. Hoffmann-La Roche Ag | Method for producing glycoprotein compositions |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| US4677195A (en) | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
| WO1990008822A1 (en) | 1989-02-03 | 1990-08-09 | Genetics Institute, Inc. | Erythropoietin receptor |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| ATE136315T1 (de) | 1989-05-27 | 1996-04-15 | Sumitomo Pharma | Verfahren für die herstellung von polyethylenglykolderivate und modifizierte proteine. |
| US5292654A (en) | 1990-12-13 | 1994-03-08 | Whitehead Institute For Biomedical Research | Mutant EPO receptor and uses therefor |
| JP3693671B2 (ja) | 1991-03-15 | 2005-09-07 | アムゲン インコーポレーテッド | ポリペプチドのｐｅｇ化 |
| WO1992016555A1 (en) | 1991-03-18 | 1992-10-01 | Enzon, Inc. | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
| US6153407A (en) | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
| US5614184A (en) | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5830851A (en) | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
| US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| US5919758A (en) | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
| US5747446A (en) | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
| US5580853A (en) | 1994-03-22 | 1996-12-03 | New England Deaconess Hospital | Modified polypeptides with increased biological activity |
| US5677280A (en) | 1995-06-07 | 1997-10-14 | Glaxo Group Limited | Peptides and compounds that bind to the IL-5 receptor |
| US5683983A (en) | 1995-06-07 | 1997-11-04 | Glaxo Group Limited | Peptides and compounds that bind to the IL-5 receptor |
| US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| BR9609006A (pt) | 1995-06-07 | 1999-12-14 | Ortho Pharma Corp | Peptìdeo, composição farmacêutica, e, processo para tratamento dse paciente. |
| BR9608587A (pt) | 1995-06-07 | 1999-01-05 | Glaxo Group Ltd | Composto que se liga ao receptor de trombopoietina composição farmacêutica e processo para o tratamento de um paciente sofrendo de um distúrbio |
| US5668110A (en) | 1995-06-07 | 1997-09-16 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| AU6046696A (en) | 1995-06-07 | 1996-12-30 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5654276A (en) | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| US6346390B1 (en) | 1996-03-08 | 2002-02-12 | Receptron, Inc. | Receptor derived peptides involved in modulation of response to ligand binding |
| US6103879A (en) | 1996-06-21 | 2000-08-15 | Axys Pharmaceuticals, Inc. | Bivalent molecules that form an activating complex with an erythropoietin receptor |
| RU2199347C2 (ru) | 1996-08-02 | 2003-02-27 | Орто-Макнейл Фармасьютикал, Инк. | Полипептиды, обладающие единственным ковалентно связанным n-концевым водорастворимым полимером |
| US5932546A (en) | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
| US6221608B1 (en) | 1997-01-22 | 2001-04-24 | Ortho Pharmaceutical Corporation | Methods for identifying erythropoietin receptor binding protein |
| EP1008355A1 (en) | 1998-12-08 | 2000-06-14 | Debio Recherche Pharmaceutique S.A. | Method for identifying or analyzing polymer linkage sites on macromolecules using amino acid report binding |
| AU764144B2 (en) * | 1998-08-28 | 2003-08-14 | Gryphon Therapeutics, Inc. | Polyamide chains of precise length, methods to manufacture them and their conjugates |
| AU773891C (en) | 1998-10-23 | 2005-02-17 | Kirin-Amgen Inc. | Dimeric thrombopoietin peptide mimetics binding to MP1 receptor and having thrombopoietic activity |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| PE20010288A1 (es) | 1999-07-02 | 2001-03-07 | Hoffmann La Roche | Derivados de eritropoyetina |
| CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| AUPQ873300A0 (en) | 2000-07-12 | 2000-08-03 | Medvet Science Pty. Ltd. | A binding motif of a receptor (2) |
| WO2001021180A1 (en) | 1999-09-24 | 2001-03-29 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| WO2001023556A1 (fr) | 1999-09-27 | 2001-04-05 | Chugai Seiyaku Kabushiki Kaisha | Nouvelle proteine receptrice d'hemopoietine (nr12) |
| US6703480B1 (en) * | 1999-11-24 | 2004-03-09 | Palani Balu | Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use |
| US6858630B2 (en) | 1999-12-06 | 2005-02-22 | Smithkline Beecham Corporation | Naphthimidazole derivatives and their use as thrombopoietin mimetics |
| US20030125262A1 (en) | 2000-03-21 | 2003-07-03 | Wisconsin Alumni Research Foundation | Methods and reagents for regulation of cellular responses in biological systems |
| US6777387B2 (en) | 2000-03-31 | 2004-08-17 | Enzon Pharmaceuticals, Inc. | Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same |
| BRPI0110914B8 (pt) | 2000-05-15 | 2021-05-25 | Hoffmann La Roche | 'composição farmacêutica líquida, processo para preparação da mesma e uso de uma composicão farmacêutica' |
| MXPA02011727A (es) * | 2000-05-26 | 2003-10-24 | Johnson & Johnson | Peptidos neuroprotectores. |
| AU2001281047A1 (en) | 2000-08-02 | 2002-02-13 | Ortho-Mcneil Pharmaceutical, Inc. | Improved anti-viral and anti-tumor chemotherapy by administration of erythropoeitin |
| HUP0303854A2 (hu) | 2000-09-08 | 2004-03-01 | Gryhon Therapeutics, Inc. | Szintetikus erythropoiesis-stimuláló proteinek |
| JP4656814B2 (ja) | 2000-12-20 | 2011-03-23 | エフ．ホフマン−ラ ロシュ アーゲー | エリスロポエチンコンジュゲート |
| US6531121B2 (en) | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
| US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| DK1362053T3 (da) | 2001-02-20 | 2008-03-10 | Enzon Inc | Terminalt forgrenede polymere linkere og polymere konjugater indeholdende disse |
| FR2823220B1 (fr) | 2001-04-04 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo) |
| US20020169128A1 (en) | 2001-04-09 | 2002-11-14 | Geroge Sigounas | Erythropoietin ameliorates chemotherapy-induced toxicity in vivo |
| US6784154B2 (en) | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
| US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| KR20060028675A (ko) | 2003-05-12 | 2006-03-31 | 아피맥스, 인크. | 신규한 폴리 (에틸렌 글리콜) 개질 화합물 및 그의 용도 |
| CN1849141A (zh) | 2003-05-12 | 2006-10-18 | 阿费麦克斯公司 | 用于聚(乙二醇)修饰的肽的间隔臂部分 |
| PT1625156E (pt) | 2003-05-12 | 2013-01-09 | Affymax Inc | Novos péptidos que se fixam ao receptor da eritropoietina |
| KR101163683B1 (ko) | 2003-05-12 | 2012-07-10 | 아피맥스, 인크. | 에리스로포이에틴 수용체에 결합하는 신규의 펩티드 |
-
2004
- 2004-05-12 KR KR1020057021601A patent/KR101163683B1/ko not_active IP Right Cessation
- 2004-05-12 RS YUP-2005/0838A patent/RS51130B/sr unknown
- 2004-05-12 CA CA2525568A patent/CA2525568C/en not_active Expired - Fee Related
- 2004-05-12 MX MXPA05012316A patent/MXPA05012316A/es active IP Right Grant
- 2004-05-12 WO PCT/US2004/014889 patent/WO2004101606A2/en active Application Filing
- 2004-05-12 SG SG200717599-5A patent/SG160224A1/en unknown
- 2004-05-12 EA EA200501801A patent/EA010095B1/ru not_active IP Right Cessation
- 2004-05-12 DK DK04760998T patent/DK1629007T3/da active
- 2004-05-12 AU AU2004238870A patent/AU2004238870B8/en not_active Ceased
- 2004-05-12 OA OA1200500316A patent/OA13164A/en unknown
- 2004-05-12 DE DE602004020610T patent/DE602004020610D1/de not_active Expired - Lifetime
- 2004-05-12 EP EP04760998A patent/EP1629007B1/en not_active Expired - Lifetime
- 2004-05-12 ES ES04760998T patent/ES2323465T3/es not_active Expired - Lifetime
- 2004-05-12 JP JP2006533000A patent/JP4266028B2/ja not_active Expired - Fee Related
- 2004-05-12 BR BRPI0411155-9A patent/BRPI0411155A/pt not_active Application Discontinuation
- 2004-05-12 AP AP2005003470A patent/AP2042A/xx active
- 2004-05-12 NZ NZ543905A patent/NZ543905A/en not_active IP Right Cessation
- 2004-05-12 PT PT04760998T patent/PT1629007E/pt unknown
- 2004-05-12 SI SI200431176T patent/SI1629007T1/sl unknown
- 2004-05-12 ME MEP-533/08A patent/MEP53308A/xx unknown
- 2004-05-12 UA UAA200511859A patent/UA88146C2/ru unknown
- 2004-05-12 US US10/844,968 patent/US7084245B2/en not_active Expired - Fee Related
- 2004-05-12 PL PL04760998T patent/PL1629007T3/pl unknown
- 2004-05-12 CN CNB2004800196261A patent/CN100441595C/zh not_active Expired - Fee Related
- 2004-05-12 AT AT04760998T patent/ATE428727T1/de active
-
2005
- 2005-10-27 US US11/261,157 patent/US7414105B2/en not_active Expired - Fee Related
- 2005-11-03 IL IL171782A patent/IL171782A/en not_active IP Right Cessation
- 2005-12-02 IS IS8165A patent/IS2683B/is unknown
- 2005-12-09 ZA ZA2005/10010A patent/ZA200510010B/en unknown
- 2005-12-09 NO NO20055852A patent/NO338435B1/no not_active IP Right Cessation
- 2005-12-12 CR CR8131A patent/CR8131A/es unknown
-
2006
- 2006-08-22 HK HK06109293.9A patent/HK1088616A1/xx not_active IP Right Cessation
-
2008
- 2008-07-11 US US12/171,610 patent/US7855175B2/en not_active Expired - Fee Related
- 2008-10-29 JP JP2008278252A patent/JP4768795B2/ja not_active Expired - Fee Related
-
2009
- 2009-04-28 CY CY20091100470T patent/CY1109028T1/el unknown
- 2009-04-29 HR HR20090251T patent/HRP20090251T1/xx unknown
-
2010
- 2010-11-12 US US12/945,687 patent/US8729030B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007530441A5 (ja) | ||
| HRP20090251T1 (en) | Novel peptides that bind to the erythropoietin receptor | |
| JP2008504237A5 (ja) | ||
| JP2020502051A5 (ja) | ||
| JP2016153410A5 (ja) | ||
| JP2003531835A5 (ja) | ||
| JP2008542399A5 (ja) | ||
| JP2005504006A5 (ja) | ||
| RU2007118385A (ru) | Контрастные агенты для направлений доставки во внеклеточный матрикс | |
| JP2008520658A5 (ja) | ||
| JP2013500990A5 (ja) | ||
| JP2005516885A5 (ja) | ||
| JP2008528445A5 (ja) | ||
| JP2009509535A5 (ja) | ||
| JP2009541288A5 (ja) | ||
| CA2452923A1 (en) | Peptide-based compounds for targeting integrin receptors | |
| JP2010515686A5 (ja) | ||
| JP2010505741A5 (ja) | ||
| JP2006523437A5 (ja) | ||
| RU2019105549A (ru) | Гидрофильные саморазрушающиеся линкеры и их конъюгаты | |
| JP2010510236A5 (ja) | ||
| JP2005538035A5 (ja) | ||
| JP2008528658A5 (ja) | ||
| JP2008508310A5 (ja) | ||
| RU2006144279A (ru) | Пептидные соединения |