JP2007525984A5 - - Google Patents
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- JP2007525984A5 JP2007525984A5 JP2007501239A JP2007501239A JP2007525984A5 JP 2007525984 A5 JP2007525984 A5 JP 2007525984A5 JP 2007501239 A JP2007501239 A JP 2007501239A JP 2007501239 A JP2007501239 A JP 2007501239A JP 2007525984 A5 JP2007525984 A5 JP 2007525984A5
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- Prior art keywords
- cell culture
- cells
- cell
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- flow
- Prior art date
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- 210000004027 cell Anatomy 0.000 claims description 53
- 238000004113 cell culture Methods 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 22
- 230000010412 perfusion Effects 0.000 claims description 22
- 239000006143 cell culture medium Substances 0.000 claims description 14
- 239000012510 hollow fiber Substances 0.000 claims description 11
- 239000002028 Biomass Substances 0.000 claims description 9
- 238000004220 aggregation Methods 0.000 claims description 5
- 230000002776 aggregation Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 4
- 238000011143 downstream manufacturing Methods 0.000 claims description 4
- 239000012620 biological material Substances 0.000 claims description 3
- 210000004962 mammalian cell Anatomy 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000011100 viral filtration Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04075702 | 2004-03-05 | ||
| EP04075703 | 2004-03-05 | ||
| EP04077656 | 2004-09-27 | ||
| EP04077657 | 2004-09-27 | ||
| PCT/EP2005/002374 WO2005095578A1 (en) | 2004-03-05 | 2005-03-04 | Process for cell culturing by continuous perfusion and alternating tangential flow |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011036102A Division JP2011125348A (ja) | 2004-03-05 | 2011-02-22 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2011259168A Division JP2012090632A (ja) | 2004-03-05 | 2011-11-28 | 連続的灌流および交互接線流による細胞培養の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007525984A JP2007525984A (ja) | 2007-09-13 |
| JP2007525984A5 true JP2007525984A5 (enExample) | 2011-04-14 |
Family
ID=34961830
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501239A Pending JP2007525984A (ja) | 2004-03-05 | 2005-03-04 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2011036102A Pending JP2011125348A (ja) | 2004-03-05 | 2011-02-22 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2011259168A Pending JP2012090632A (ja) | 2004-03-05 | 2011-11-28 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2014016778A Expired - Fee Related JP5719947B2 (ja) | 2004-03-05 | 2014-01-31 | 灌流培養方法の、細胞培養物中の細胞の凝集度合いを減少させるための使用 |
| JP2015209828A Pending JP2016039817A (ja) | 2004-03-05 | 2015-10-26 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2017132997A Pending JP2017225443A (ja) | 2004-03-05 | 2017-07-06 | 連続的灌流および交互接線流による細胞培養の方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011036102A Pending JP2011125348A (ja) | 2004-03-05 | 2011-02-22 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2011259168A Pending JP2012090632A (ja) | 2004-03-05 | 2011-11-28 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2014016778A Expired - Fee Related JP5719947B2 (ja) | 2004-03-05 | 2014-01-31 | 灌流培養方法の、細胞培養物中の細胞の凝集度合いを減少させるための使用 |
| JP2015209828A Pending JP2016039817A (ja) | 2004-03-05 | 2015-10-26 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2017132997A Pending JP2017225443A (ja) | 2004-03-05 | 2017-07-06 | 連続的灌流および交互接線流による細胞培養の方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8206981B2 (enExample) |
| EP (3) | EP2308958A3 (enExample) |
| JP (6) | JP2007525984A (enExample) |
| KR (1) | KR101050585B1 (enExample) |
| CN (3) | CN104593277A (enExample) |
| AU (1) | AU2005229359C1 (enExample) |
| CA (1) | CA2557046A1 (enExample) |
| DK (1) | DK1720972T3 (enExample) |
| ES (1) | ES2456015T3 (enExample) |
| IL (2) | IL177724A (enExample) |
| PL (1) | PL1720972T3 (enExample) |
| PT (1) | PT1720972E (enExample) |
| SI (1) | SI1720972T1 (enExample) |
| WO (1) | WO2005095578A1 (enExample) |
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| PT2574677T (pt) * | 2007-12-27 | 2017-10-19 | Baxalta Inc | Processos para cultura de células |
| WO2010003759A2 (en) * | 2008-06-17 | 2010-01-14 | Dsm Ip Assets B.V. | Cell culturing method |
| RU2539786C2 (ru) * | 2008-09-02 | 2015-01-27 | Плуристем Лтд. | Выращенные в прикрепленной к субстрату культуре клетки из ткани плаценты и их использование при лечении |
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2005
- 2005-03-04 AU AU2005229359A patent/AU2005229359C1/en not_active Ceased
- 2005-03-04 CA CA002557046A patent/CA2557046A1/en not_active Withdrawn
- 2005-03-04 ES ES05715787.7T patent/ES2456015T3/es not_active Expired - Lifetime
- 2005-03-04 WO PCT/EP2005/002374 patent/WO2005095578A1/en not_active Ceased
- 2005-03-04 JP JP2007501239A patent/JP2007525984A/ja active Pending
- 2005-03-04 EP EP10183651A patent/EP2308958A3/en not_active Withdrawn
- 2005-03-04 CN CN201410471955.5A patent/CN104593277A/zh active Pending
- 2005-03-04 US US10/591,118 patent/US8206981B2/en active Active
- 2005-03-04 EP EP05715787.7A patent/EP1720972B1/en not_active Revoked
- 2005-03-04 PL PL05715787T patent/PL1720972T3/pl unknown
- 2005-03-04 CN CNA2005800071754A patent/CN1930281A/zh active Pending
- 2005-03-04 CN CN201410601800.9A patent/CN104388324A/zh active Pending
- 2005-03-04 EP EP12186351A patent/EP2540815A1/en not_active Ceased
- 2005-03-04 SI SI200531842T patent/SI1720972T1/sl unknown
- 2005-03-04 PT PT57157877T patent/PT1720972E/pt unknown
- 2005-03-04 KR KR1020067018075A patent/KR101050585B1/ko not_active Ceased
- 2005-03-04 DK DK05715787.7T patent/DK1720972T3/da active
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2012
- 2012-05-23 US US13/478,307 patent/US20130266985A1/en not_active Abandoned
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2014
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